Detailed information for compound 301858

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 361.523 | Formula: C24H31N3
  • H donors: 0 H acceptors: 1 LogP: 5.11 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(c1ccccc1)(C(C)C)CCCN1CCN(CC1)c1ccccc1
  • InChi: 1S/C24H31N3/c1-21(2)24(20-25,22-10-5-3-6-11-22)14-9-15-26-16-18-27(19-17-26)23-12-7-4-8-13-23/h3-8,10-13,21H,9,14-19H2,1-2H3
  • InChiKey: XMVLLHGKYLJMKX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni DNA polymerase eta 0.005 0.0567 0.0567
Trypanosoma cruzi metacaspase, putative 0.0059 0.0688 0.798
Loa Loa (eye worm) TOPoisomerase family member 0.0015 0.0106 0.015
Brugia malayi heat shock protein 90 0.0072 0.0863 0.1221
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0015 0.0106 0.1105
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0015 0.0106 0.1105
Brugia malayi Cell death protein 3 precursor 0.0059 0.0688 0.0975
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0036 0.0417
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0401 0.0567
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0061 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.058 0.058
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0195 0.0275
Leishmania major P-type H -ATPase, putative 0.0009 0.0036 0.0417
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0015 0.0106 0.1584
Schistosoma mansoni zinc finger protein 0.0015 0.0111 0.0111
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0036 0.0417
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0051
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0124 0.0175
Echinococcus granulosus caspase 3 0.0161 0.2039 0.2016
Echinococcus multilocularis muscleblind protein 1 0.0314 0.4049 0.4032
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0009 0.0036 0.0008
Echinococcus multilocularis protein quaking 0.003 0.031 0.0283
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0107 0.124
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0086
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0036 0.0051
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0036 0.0417
Schistosoma mansoni caspase-7 (C14 family) 0.0059 0.0688 0.0688
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0061 0.0086
Brugia malayi Hsp90 protein 0.003 0.0302 0.0427
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0036 0.0051
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0307 0.0434
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4604 0.6515
Entamoeba histolytica heat shock protein 90, putative 0.0072 0.0863 0.9474
Trypanosoma cruzi proton motive ATPase 1, putative 0.0009 0.0036 0.0417
Echinococcus granulosus tumor protein p63 0.0375 0.4852 0.4837
Onchocerca volvulus 0.0011 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0086
Leishmania major DNA polymerase eta, putative 0.005 0.0567 0.6572
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0061 0.0706
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0036 0.0051
Plasmodium vivax P-type ATPase4, putative 0.0009 0.0036 0.0417
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0195 0.0167
Brugia malayi steroid hormone receptor 0.0011 0.0061 0.0086
Mycobacterium ulcerans two component sensor kinase MprB 0.0015 0.0106 0.1584
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0143 0.1662
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0143 0.1662
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0009 0.0036 0.0008
Trichomonas vaginalis heat shock protein, putative 0.0057 0.0669 0.0938
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4604 0.6515
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0036 0.0417
Trypanosoma brucei cation-transporting ATPase, putative 0.0009 0.0036 0.0417
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4604 0.6515
Loa Loa (eye worm) hypothetical protein 0.003 0.031 0.0439
Plasmodium vivax endoplasmin, putative 0.0072 0.0863 1
Leishmania major hypothetical protein, conserved 0.0015 0.0106 0.1228
Trypanosoma brucei heat shock protein, putative 0.0072 0.0863 1
Plasmodium vivax heat shock protein, putative 0.003 0.0302 0.3498
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Brugia malayi isocitrate dehydrogenase 0.0018 0.0143 0.0203
Entamoeba histolytica hypothetical protein 0.0076 0.0909 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0061 0.0086
Loa Loa (eye worm) hypothetical protein 0.0015 0.0106 0.015
Loa Loa (eye worm) E1-E2 ATPase 0.0009 0.0036 0.0051
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0015 0.0106 0.1228
Echinococcus multilocularis cation transporting atpase worm 0.0009 0.0036 0.0008
Toxoplasma gondii heat shock protein 90, putative 0.0072 0.0863 1
Schistosoma mansoni zinc finger protein 0.0021 0.0191 0.0191
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0143 0.1662
Brugia malayi Bromodomain containing protein 0.0076 0.0911 0.129
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0033 0.0005
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0015 0.0106 0.017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0061 0.0086
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0036 0.004
Onchocerca volvulus 0.0263 0.3384 0.7334
Mycobacterium ulcerans putative regultory protein 0.0015 0.0106 0.1584
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0082 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.7063 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0401 0.0557
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0015 0.0106 0.1584
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0543 0.7063 1
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0009 0.0036 0.0008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0688 0.0965
Mycobacterium tuberculosis Probable two component sensor kinase 0.0015 0.0106 0.1105
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0009 0.0036 0.0538
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0086
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0015 0.0106 0.0139
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0688 0.0965
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0061 0.0086
Leishmania major metacaspase, putative 0.0059 0.0688 0.798
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0061 0.0072
Echinococcus multilocularis zinc finger protein 0.0021 0.0191 0.0163
Brugia malayi hypothetical protein 0.0076 0.0909 0.1286
Schistosoma mansoni eyes absent homolog 0.0098 0.1201 0.1201
Trypanosoma brucei metacaspase 0.0059 0.0688 0.798
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0009 0.0036 0.0008
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0015 0.0106 0.1584
Trypanosoma cruzi metacaspase 5, putative 0.0059 0.0688 0.798
Brugia malayi ecdysteroid receptor 0.0011 0.0061 0.0086
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0058 0.0031
Schistosoma mansoni hypothetical protein 0.0454 0.5892 0.5892
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0688 0.0965
Brugia malayi hypothetical protein 0.0009 0.0036 0.0051
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0061 0.0061
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0036 0.0051
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0061 0.0033
Onchocerca volvulus 0.003 0.0307 0.0609
Echinococcus multilocularis heat shock protein 0.0072 0.0863 0.0837
Leishmania major developmentally regulated phosphoprotein-like protein 0.0015 0.0106 0.1228
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.7063 1
Trypanosoma cruzi copper-transporting ATPase, putative 0.0009 0.0036 0.0417
Trichomonas vaginalis receptor histidine kinase, putative 0.0015 0.0106 0.0139
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0061 0.0033
Trichomonas vaginalis DNA topoisomerase II, putative 0.0015 0.0106 0.0139
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0036 0.0389 0.4511
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0028 0.004
Trypanosoma brucei DNA topoisomerase ii 0.0015 0.0106 0.1228
Trypanosoma cruzi DNA topoisomerase II, putative 0.0015 0.0106 0.1228
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0033 0.0005
Echinococcus multilocularis caspase 8 0.0059 0.0688 0.0662
Trypanosoma brucei heat shock protein, putative 0.0072 0.0863 1
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0036 0.0008
Plasmodium falciparum copper-transporting ATPase 0.0009 0.0036 0.0417
Schistosoma mansoni hypothetical protein 0.003 0.031 0.031
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0061 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0688 0.0965
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0036 0.0417
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0195 0.2907
Toxoplasma gondii P-type ATPase4, putative 0.0009 0.0036 0.0417
Plasmodium vivax heat shock protein 86, putative 0.0072 0.0863 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0195 0.2504
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0028 0.004
Trichomonas vaginalis rotamase, putative 0.0036 0.0389 0.0541
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0009 0.0036 0.004
Schistosoma mansoni cpg binding protein 0.0036 0.0381 0.0381
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0229 0.0202
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0057 0.0669 0.7757
Echinococcus granulosus heat shock protein 90 0.0057 0.0669 0.0643
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0061 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0688 0.798
Giardia lamblia DINP protein human, muc B family 0.0021 0.0195 0.2255
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Onchocerca volvulus 0.0032 0.0332 0.0665
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0015 0.0106 0.1584
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0057 0.0669 1
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0009 0.0036 0.0417
Trypanosoma brucei metacaspase 5, putative 0.0059 0.0688 0.798
Trypanosoma brucei heat shock protein, putative 0.0072 0.0863 1
Trypanosoma brucei heat shock protein, putative 0.0072 0.0863 1
Schistosoma mansoni caspase-3 (C14 family) 0.022 0.2815 0.2815
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0134 0.0106
Schistosoma mansoni survival motor neuron protein 0.0054 0.0618 0.0618
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Schistosoma mansoni heat shock protein 0.0072 0.0863 0.0863
Trypanosoma brucei heat shock protein, putative 0.0072 0.0863 1
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4604 0.6515
Schistosoma mansoni hypothetical protein 0.002 0.0181 0.0181
Echinococcus granulosus dnaJ subfamily B 0.0454 0.5892 0.588
Schistosoma mansoni heat shock protein 0.003 0.0302 0.0302
Schistosoma mansoni endoplasmin 0.0072 0.0863 0.0863
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0143 0.1662
Leishmania major DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Onchocerca volvulus Cell death protein 3 homolog 0.0059 0.0688 0.1443
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0015 0.0106 0.015
Echinococcus granulosus heat shock protein 90 0.0072 0.0863 0.0837
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.3369 0.3351
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0302 0.0275
Mycobacterium ulcerans heat shock protein 90 0.0057 0.0669 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0061 0.0086
Echinococcus multilocularis cpg binding protein 0.0036 0.0381 0.0354
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.2964 0.4196
Trichomonas vaginalis endoplasmin, putative 0.0044 0.0495 0.0691
Trichomonas vaginalis heat shock protein, putative 0.003 0.0302 0.0417
Onchocerca volvulus 0.0009 0.0036 0.0018
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0009 0.0036 0.0417
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0819 0.0819
Loa Loa (eye worm) hypothetical protein 0.0059 0.0688 0.0975
Echinococcus multilocularis cation transporting ATPase 13A1 0.0009 0.0036 0.0008
Schistosoma mansoni heat shock protein 0.0072 0.0863 0.0863
Trichomonas vaginalis glucosylceramidase, putative 0.0375 0.4857 0.6873
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.7063 1
Trypanosoma cruzi heat shock protein 85, putative 0.0072 0.0863 1
Trypanosoma brucei heat shock protein, putative 0.0072 0.0863 1
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0009 0.0036 0.0051
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0015 0.0106 0.1105
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.004
Loa Loa (eye worm) hypothetical protein 0.0044 0.0491 0.0695
Entamoeba histolytica hypothetical protein 0.0076 0.0909 1
Trypanosoma brucei unspecified product 0.0021 0.0195 0.2255
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0059 0.0688 0.798
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Brugia malayi Pre-SET motif family protein 0.0232 0.2964 0.4196
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0061 0.0061
Echinococcus granulosus endoplasmin 0.0057 0.0669 0.0643
Toxoplasma gondii heat shock protein HSP90 0.0072 0.0863 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0015 0.0106 0.1228
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0143 0.0116
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0372 0.4316
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0688 0.0965
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0061 0.0086
Echinococcus granulosus dna polymerase kappa 0.0021 0.0195 0.0167
Brugia malayi DIX domain containing protein 0.0009 0.0028 0.004
Echinococcus granulosus muscleblind protein 0.0314 0.4049 0.4032
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0028 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0061 0.0086
Schistosoma mansoni lamin 0.003 0.0307 0.0307
Echinococcus multilocularis expressed protein 0.0037 0.0401 0.0374
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.7063 1
Onchocerca volvulus 0.0054 0.0618 0.1288
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0061 0.0033
Leishmania major DNA polymerase eta, putative 0.0035 0.0372 0.4316
Echinococcus granulosus lamin 0.003 0.0307 0.0279
Plasmodium vivax copper-transporting ATPase, putative 0.0009 0.0036 0.0417
Loa Loa (eye worm) hypothetical protein 0.004 0.0442 0.0626
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0009 0.0036 0.0538
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0688 0.0965
Mycobacterium leprae Probable two-component sensor kinase 0.0015 0.0106 0.1105
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0195 0.0275
Trypanosoma cruzi DNA topoisomerase II, putative 0.0015 0.0106 0.1228
Echinococcus granulosus cpg binding protein 0.0036 0.0381 0.0354
Trichomonas vaginalis receptor histidine kinase, putative 0.0015 0.0106 0.0139
Loa Loa (eye worm) hypothetical protein 0.0059 0.0688 0.0975
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0061 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4604 0.6515
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0036 0.0008
Trypanosoma cruzi heat shock protein, putative 0.003 0.0302 0.3498
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0333 0.0306
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0009 0.0036 0.0417
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0061 0.0061
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0143 0.0116
Schistosoma mansoni caspase-7 (C14 family) 0.022 0.2815 0.2815
Trichomonas vaginalis heat shock protein, putative 0.0057 0.0669 0.0938
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0015 0.0106 0.1105
Brugia malayi hypothetical protein 0.0009 0.0028 0.004
Trypanosoma cruzi Heat shock protein 83, putative 0.0072 0.0863 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0095 0.0135
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0036 0.0417
Echinococcus multilocularis microtubule associated protein 2 0.0765 1 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0015 0.0106 0.015
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0036 0.0036
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0061 0.0033
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0028 0.0028
Chlamydia trachomatis DNA gyrase subunit B 0.0015 0.0106 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0909 0.0883
Trypanosoma cruzi cation-transporting ATPase, putative 0.0009 0.0036 0.0417
Trypanosoma brucei unspecified product 0.0015 0.0107 0.124
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0036 0.0417
Trichomonas vaginalis sensor histidine kinase, putative 0.0015 0.0106 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0061 0.0086
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0036 0.004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0411 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0061 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0086
Echinococcus granulosus caspase 0.022 0.2815 0.2794
Loa Loa (eye worm) hypothetical protein 0.0314 0.4049 0.5732
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0015 0.0106 0.017
Trypanosoma brucei heat shock protein 90, putative 0.0072 0.0863 1
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Trypanosoma brucei heat shock protein 90, putative 0.0072 0.0863 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0712 0.0686
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0143 0.0203
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0036 0.0008
Trypanosoma cruzi ISWI complex protein 0.0015 0.0111 0.129
Brugia malayi hypothetical protein 0.003 0.031 0.0439
Loa Loa (eye worm) intermediate filament protein 0.003 0.0307 0.0434
Trypanosoma cruzi ISWI complex protein 0.0015 0.0111 0.129
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0015 0.0106 0.0741
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0009 0.0036 0.0417
Brugia malayi ImpB/MucB/SamB family protein 0.005 0.0567 0.0803
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0036 0.0036
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0302 0.3498
Brugia malayi nuclear receptor NHR-88 0.0011 0.0061 0.0086
Schistosoma mansoni coup transcription factor 0.0011 0.0061 0.0061
Schistosoma mansoni rotamase 0.0037 0.0401 0.0401
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0061 0.0086
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0061 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0061 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0061 0.0086
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0061 0.0706
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0009 0.0036 0.0538
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0195 0.0195
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0036 0.0036
Plasmodium vivax heat shock protein 90, putative 0.003 0.0302 0.3498
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0142 0.0201
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0181 0.0256
Loa Loa (eye worm) hypothetical protein 0.007 0.0832 0.1178
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0375 0.4857 0.6873
Toxoplasma gondii DNA topoisomerase 2, putative 0.0015 0.0106 0.1228
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0061 0.0033
Onchocerca volvulus 0.003 0.0307 0.0609
Echinococcus multilocularis caspase 0.022 0.2815 0.2794
Plasmodium falciparum heat shock protein 90 0.0072 0.0863 1
Loa Loa (eye worm) tumor suppressor 0.0357 0.4613 0.6532
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0061 0.0061
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0302 0.3498
Loa Loa (eye worm) hypothetical protein 0.0029 0.0299 0.0424
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0061 0.0061
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0009 0.0036 0.0538
Plasmodium falciparum DNA gyrase subunit B 0.0015 0.0106 0.1228
Echinococcus multilocularis tumor protein p63 0.0375 0.4852 0.4837
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0036 0.0389 0.4511
Echinococcus granulosus expressed protein 0.0037 0.0401 0.0374
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0143 0.0116
Trypanosoma cruzi heat shock protein 90, putative 0.0057 0.0669 0.7757
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0028 0.004
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0036 0.004
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0015 0.0106 0.1105
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0015 0.0106 0.1105
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0058 0.0083
Giardia lamblia Copper-transporting P-type ATPase 0.0009 0.0036 0.0417
Trypanosoma cruzi heat shock protein 85, putative 0.0072 0.0863 1
Schistosoma mansoni microtubule-associated protein tau 0.0765 1 1
Brugia malayi N-terminal motif family protein 0.0178 0.2259 0.3199
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0134 0.0106
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0009 0.0036 0.0051
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0302 0.0598
Leishmania major heat shock protein, putative 0.003 0.0302 0.3498
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0015 0.0106 0.0078
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0036 0.0036
Trypanosoma cruzi metacaspase, putative 0.0059 0.0688 0.798
Leishmania major calcium-translocating P-type ATPase 0.0009 0.0036 0.0417
Plasmodium falciparum heat shock protein 90, putative 0.003 0.0302 0.3498
Toxoplasma gondii hypothetical protein 0.0009 0.0028 0.0324
Schistosoma mansoni hypothetical protein 0.003 0.031 0.031
Trypanosoma cruzi heat shock protein 90, putative 0.0043 0.0473 0.5487
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0036 0.004
Trypanosoma brucei heat shock protein, putative 0.0072 0.0863 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0143 0.0143
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0015 0.0106 0.0139
Entamoeba histolytica DNA topoisomerase II, putative 0.0015 0.0106 0.0802
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0036 0.004
Loa Loa (eye worm) hypothetical protein 0.0098 0.1201 0.17
Echinococcus multilocularis lamin dm0 0.003 0.0307 0.0279
Echinococcus granulosus caspase 2 0.0059 0.0688 0.0662
Plasmodium falciparum metacaspase-like protein 0.0059 0.0688 0.798
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0061 0.0061
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.022 0.2815 0.2794
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0015 0.0106 0.1105
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0195 0.2907
Leishmania major hypothetical protein, conserved 0.0015 0.0111 0.129
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0033 0.0005
Plasmodium falciparum metacaspase 1 0.0059 0.0688 0.798
Brugia malayi Probable DNA topoisomerase II 0.0015 0.0106 0.015
Schistosoma mansoni hypothetical protein 0.0076 0.0909 0.0909
Onchocerca volvulus Glucosylceramidase homolog 0.0356 0.4604 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0302 0.3046
Onchocerca volvulus 0.0034 0.0358 0.0721
Toxoplasma gondii P-type ATPase PMA1 0.0009 0.0036 0.0417
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0059 0.0688 0.798
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0061 0.0086
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0332 0.047
Trypanosoma cruzi heat shock protein 90, putative 0.0072 0.0863 1
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0036 0.0417
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0009 0.0036 0.004
Echinococcus multilocularis copper transporting ATPase 1 0.0009 0.0036 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0051
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0061 0.0072
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0195 0.0265
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0143 0.1662
Brugia malayi hypothetical protein 0.0262 0.3369 0.477
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0107 0.124
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0195 0.0167
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0009 0.0036 0.004
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0302 0.0275
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0143 0.1662
Plasmodium vivax metacaspase 1, putative 0.0059 0.0688 0.798
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0057 0.0669 1
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0688 0.0965
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0009 0.0036 0.0008
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0015 0.0106 0.1105
Loa Loa (eye worm) hypothetical protein 0.005 0.0567 0.0803
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0009 0.0036 0.0417
Echinococcus multilocularis dna polymerase eta 0.005 0.0567 0.054
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0061 0.0033
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0009 0.0036 0.0008
Schistosoma mansoni dishevelled 0.0009 0.0028 0.0028
Brugia malayi tumor suppressor. 0.0357 0.4613 0.6532
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0009 0.0036 0.0538
Brugia malayi CXXC zinc finger family protein 0.0032 0.0332 0.047
Trypanosoma brucei metacaspase MCA3 0.0059 0.0688 0.798
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0009 0.0036 0.0417
Schistosoma mansoni intermediate filament proteins 0.003 0.0307 0.0307
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0106 0.1228
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0061 0.0033
Mycobacterium ulcerans two component regulator - sensor kinase 0.0015 0.0106 0.1584
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0061 0.0061
Trichomonas vaginalis rotamase, putative 0.0037 0.0401 0.0557
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0036 0.0008
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0015 0.0106 0.1228
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0143 0.1696
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0229 0.0202
Plasmodium vivax calcium-transporting ATPase, putative 0.0009 0.0036 0.0417
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.7063 1
Schistosoma mansoni dishevelled 0.0009 0.0028 0.0028
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0143 0.1662
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0688 0.0965
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0015 0.0106 0.1584
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0061 0.0086
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0015 0.0106 0.1105
Echinococcus multilocularis muscleblind protein 0.0314 0.4049 0.4032
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0036 0.0417
Echinococcus granulosus lamin dm0 0.003 0.0307 0.0279
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0059 0.0688 0.798
Trypanosoma brucei developmentally regulated phosphoprotein 0.0015 0.0106 0.1228
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0061 0.0706
Schistosoma mansoni dep domain containing protein 0.0009 0.0028 0.0028
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0688 0.0965
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0009 0.0036 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Trypanosoma brucei ISWI complex protein 0.0015 0.0111 0.129
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0712 0.0686
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0009 0.0036 0.0008
Brugia malayi hypothetical protein 0.0009 0.0028 0.004
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0015 0.0106 0.1228
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0618 0.0874
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0015 0.0106 0.1105
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.004
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0143 0.0116
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0036 0.004
Leishmania major copper-transporting ATPase-like protein, putative 0.0009 0.0036 0.0417
Trypanosoma brucei unspecified product 0.0015 0.0107 0.124
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0195 0.1817
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0015 0.0106 0.0741
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0009 0.0036 0.0417
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0015 0.0106 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0036 0.004
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0036 0.0036
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0195 0.0265
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.038 0.0353
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.0567 0.6572
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0015 0.0106 0.1105
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Echinococcus multilocularis musashi 0.003 0.0307 0.0279
Mycobacterium tuberculosis Possible two component sensor kinase 0.0015 0.0106 0.1105
Echinococcus granulosus heat shock protein 0.0072 0.0863 0.0837
Giardia lamblia Grp94/Hsp90 0.0057 0.0669 0.7757
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0028 0.0028
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0036 0.0417
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0195 0.2255
Echinococcus multilocularis cation transporting ATPase 13A3 0.0009 0.0036 0.0008
Onchocerca volvulus 0.0055 0.0635 0.1327
Trypanosoma cruzi metacaspase, putative 0.0059 0.0688 0.798
Trypanosoma cruzi metacaspase 5, putative 0.0059 0.0688 0.798
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0051
Schistosoma mansoni pyruvate dehydrogenase 0.0015 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0314 0.4049 0.5732
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0015 0.0106 0.1105
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0015 0.0106 0.0139
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0015 0.0106 0.0139
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0143 0.0203
Plasmodium vivax SET domain protein, putative 0.0034 0.0358 0.415
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0015 0.0106 0.0078
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0015 0.0106 0.1584
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0036 0.0036
Echinococcus multilocularis endoplasmin 0.0057 0.0669 0.0643
Schistosoma mansoni DNA topoisomerase II 0.0015 0.0106 0.0106
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0059 0.0688 0.0688
Loa Loa (eye worm) hypothetical protein 0.0051 0.058 0.0821
Brugia malayi Pre-SET motif family protein 0.0034 0.0358 0.0507
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0015 0.0106 0.1584
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0195 0.2255
Plasmodium falciparum DNA topoisomerase 2 0.0015 0.0106 0.1228
Schistosoma mansoni lamin 0.003 0.0307 0.0307
Brugia malayi PHD-finger family protein 0.0026 0.026 0.0368
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0036 0.0036
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0009 0.0036 0.0538
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0086
Echinococcus multilocularis caspase 3 0.0161 0.2039 0.2016
Plasmodium vivax DNA topoisomerase II, putative 0.0015 0.0106 0.1228
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Echinococcus granulosus phospholipid transporting ATPase VA 0.0009 0.0036 0.0008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0358 0.0331
Brugia malayi intermediate filament protein 0.003 0.0307 0.0434
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.0434
Schistosoma mansoni cpg binding protein 0.0036 0.0381 0.0381
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0195 0.0195
Brugia malayi Endoplasmin precursor 0.0072 0.0863 0.1221
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0103 0.0075
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0015 0.0106 0.0741
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0015 0.0106 0.1228
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.004
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0389 0.4511
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.3369 0.3351
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0009 0.0036 0.0417
Trichomonas vaginalis heat shock protein, putative 0.0072 0.0863 0.1212
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0688 0.0965
Trichomonas vaginalis set domain proteins, putative 0.0263 0.3384 0.4786
Loa Loa (eye worm) hypothetical protein 0.0098 0.1201 0.17
Chlamydia trachomatis DNA gyrase subunit B 0.0015 0.0106 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0755 0.8747
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0028 0.004
Echinococcus granulosus protein quaking 0.003 0.031 0.0283
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0145
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0009 0.0036 0.0417
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0009 0.0036 0.0538
Trypanosoma brucei Heat shock protein 83, putative 0.0072 0.0863 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0015 0.0106 0.017
Loa Loa (eye worm) hypothetical protein 0.0015 0.0106 0.015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0106 0.015
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4604 0.6515
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0061 0.0033
Giardia lamblia Pms1-like protein 0.0015 0.0106 0.1228
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Echinococcus granulosus copper transporting ATPase 1 0.0009 0.0036 0.0008
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0036 0.0036
Trichomonas vaginalis heat shock protein, putative 0.0057 0.0669 0.0938
Echinococcus multilocularis heat shock protein 90 0.0057 0.0669 0.0643
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0036 0.004
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0015 0.0106 0.1228
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0009 0.0036 0.004
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0015 0.0106 0.1228
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0036 0.004
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0061 0.0033
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0015 0.0106 0.0078
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.058 0.0553
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0061 0.0033
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Treponema pallidum heat shock protein 90 0.0057 0.0669 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0057 0.0669 1
Leishmania major mitochondrial DNA topoisomerase II 0.0015 0.0106 0.1228
Mycobacterium leprae Probable two component sensor kinase MprB 0.0015 0.0106 0.1105
Trypanosoma brucei metacaspase MCA2 0.0059 0.0688 0.798
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0143 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4604 0.6515
Loa Loa (eye worm) endoplasmin 0.0072 0.0863 0.1221
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0372 0.4316
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0358 0.415
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0195 0.2255
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0036 0.0008
Leishmania major P-type H -ATPase, putative 0.0009 0.0036 0.0417
Plasmodium falciparum endoplasmin, putative 0.0044 0.0495 0.5742
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0358 0.0358
Trypanosoma cruzi heat shock protein 85, putative 0.0072 0.0863 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0015 0.0106 0.1228
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0688 0.0965
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0103 0.0075
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0036 0.0389 0.4048
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0061 0.0086
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0015 0.0106 0.0078
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0036 0.0036
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0015 0.0106 0.1105
Giardia lamblia Heat shock protein HSP 90-alpha 0.0057 0.0669 0.7757
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0061 0.0086
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0058 0.0031
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0061 0.0061
Echinococcus multilocularis caspase 2 0.0059 0.0688 0.0662
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0229 0.0229
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0009 0.0036 0.0538
Echinococcus multilocularis lamin 0.003 0.0307 0.0279
Leishmania major DNA topoisomerase ii 0.0015 0.0106 0.1228
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0061 0.0086
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0009 0.0036 0.0051
Trypanosoma brucei heat shock protein, putative 0.0072 0.0863 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.022 0.2815 0.2794
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0307 0.0434
Schistosoma mansoni hypothetical protein 0.0054 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0051
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0195 0.2504
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0036 0.0417
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0061 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0143 0.0116
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0061 0.0033
Echinococcus granulosus cation transporting ATPase 13A1 0.0009 0.0036 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.058 0.0553
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0033 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0061 0.0033
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0036 0.004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0688 0.0965
Schistosoma mansoni cpg binding protein 0.0032 0.0332 0.0332
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.038 0.0353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0061 0.0086
Loa Loa (eye worm) heat shock protein 75 0.003 0.0302 0.0427
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0688 0.0965
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0061 0.0086
Schistosoma mansoni ATPase 0.0009 0.0036 0.0036
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0495 0.0691
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0015 0.0106 0.1228
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0009 0.0036 0.0417
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0635 0.0635
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0015 0.0106 0.0139
Schistosoma mansoni bromodomain containing protein 0.0064 0.0759 0.0759
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0688 0.0965
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0061 0.0086
Echinococcus granulosus caspase 8 0.0059 0.0688 0.0662
Brugia malayi Bromodomain containing protein 0.0038 0.041 0.0581
Schistosoma mansoni ATPase 0.0009 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0178 0.2259 0.3199
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0015 0.0106 0.1228
Brugia malayi kinase, mitochondrial precursor 0.0015 0.0106 0.015
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0015 0.0106 0.0078
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0015 0.0106 0.1228
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0107 0.124
Plasmodium vivax DNA gyrase subunit B, putative 0.0015 0.0106 0.1228
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0051
Echinococcus granulosus dna polymerase eta 0.005 0.0567 0.054
Schistosoma mansoni endoplasmin 0.0072 0.0863 0.0863
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0909 0.0909
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0015 0.0106 0.1105
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Echinococcus multilocularis dnaJ subfamily B 0.0454 0.5892 0.588
Trypanosoma cruzi metacaspase, putative 0.0059 0.0688 0.798
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0061 0.0072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0033 0.0033
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0061 0.0706
Brugia malayi Muscleblind-like protein 0.0314 0.4049 0.5732
Trypanosoma brucei DNA polymerase eta, putative 0.005 0.0567 0.6572
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.7063 1
Toxoplasma gondii Hsp90 domain-containing protein 0.003 0.0302 0.3498
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0036 0.0417
Entamoeba histolytica hypothetical protein 0.0076 0.0909 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.2259 0.4876
Loa Loa (eye worm) hypothetical protein 0.0262 0.3369 0.477
Echinococcus granulosus intermediate filament protein 0.003 0.0307 0.0279
Plasmodium falciparum heat shock protein 90, putative 0.003 0.0302 0.3498
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0195 0.2255
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0389 0.4511
Echinococcus granulosus zinc finger protein 0.0021 0.0191 0.0163
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0143 0.1662
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0401 0.0567
Giardia lamblia Heat shock protein HSP 90-alpha 0.0072 0.0863 1
Mycobacterium tuberculosis Conserved protein 0.0015 0.0106 0.1105
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0036 0.0008
Brugia malayi nuclear hormone receptor 0.0011 0.0061 0.0086
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Mycobacterium ulcerans DNA gyrase subunit B 0.0015 0.0106 0.1584
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0086
Schistosoma mansoni hypothetical protein 0.0015 0.0111 0.0111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0061 0.0033
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0014 0.0095 0.0135
Entamoeba histolytica hypothetical protein 0.0076 0.0909 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0059 0.0688 0.0975
Leishmania major proton motive ATPase, putative 0.0009 0.0036 0.0417
Plasmodium vivax cation transporting ATPase, putative 0.0009 0.0036 0.0417
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0009 0.0036 0.0538
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0061 0.0706
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0036 0.0008
Toxoplasma gondii cation-transporting atpase family protein 0.0009 0.0036 0.0417
Trypanosoma brucei Metacaspase-4 0.0059 0.0688 0.798
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0061 0.0086
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0015 0.0106 0.1584
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0009 0.0036 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0688 0.0965
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0061 0.0061
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0195 0.0167
Leishmania major heat shock protein 83-1 0.0072 0.0863 1
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0036 0.0008
Echinococcus granulosus cation transporting atpase worm 0.0009 0.0036 0.0008
Echinococcus multilocularis heat shock protein 90 0.0072 0.0863 0.0837
Loa Loa (eye worm) hypothetical protein 0.0055 0.0635 0.09
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0909 0.0883
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0009 0.0036 0.0417
Brugia malayi hypothetical protein 0.0098 0.1201 0.17
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0124 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0061 0.0086
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0009 0.0036 0.0417
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0009 0.0036 0.0417
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0028 0.0028
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0057 0.0669 0.0643
Echinococcus granulosus hypothetical protein 0.003 0.031 0.0283
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0061 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0195 0.2255
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0143 0.1662
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0543 0.7063 1
Loa Loa (eye worm) calcium ATPase 0.0009 0.0036 0.0051
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0015 0.0106 0.1105
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0061 0.0061
Loa Loa (eye worm) heat shock protein 90 0.0072 0.0863 0.1221
Toxoplasma gondii peptidylprolyl isomerase 0.0036 0.0389 0.4511
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0061 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.058 0.058
Trypanosoma cruzi heat shock protein 85, putative 0.0057 0.0669 0.7757
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0036 0.0417
Echinococcus granulosus cation transporting ATPase 13A3 0.0009 0.0036 0.0008
Brugia malayi Na,K-ATPase alpha subunit 0.0009 0.0036 0.0051
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0086
Brugia malayi Temporarily assigned gene name protein 44 0.003 0.031 0.0439
Entamoeba histolytica heat shock protein 90, putative 0.0072 0.0863 0.9474

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 16 uM Neuronal voltage-dependent calcium channel (VDCC) inhibitory activity determined in rat cortical synaptosomes ChEMBL. 12617921

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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