Detailed information for compound 416103

Basic information

Technical information
  • TDR Targets ID: 416103
  • Name: 2-amino-N-hydroxy-N'-[[4-(trifluoromethyl)phe nyl]methyl]propanediamide
  • MW: 291.226 | Formula: C11H12F3N3O3
  • H donors: 4 H acceptors: 3 LogP: 0.07 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)C(C(=O)NCc1ccc(cc1)C(F)(F)F)N
  • InChi: 1S/C11H12F3N3O3/c12-11(13,14)7-3-1-6(2-4-7)5-16-9(18)8(15)10(19)17-20/h1-4,8,20H,5,15H2,(H,16,18)(H,17,19)
  • InChiKey: DYXNPPFTNJWJBZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-3-(hydroxyamino)-3-oxo-N-[[4-(trifluoromethyl)phenyl]methyl]propanamide
  • 2-azanyl-N-hydroxy-N'-[[4-(trifluoromethyl)phenyl]methyl]propanediamide
  • 2-amino-3-(hydroxyamino)-3-keto-N-[4-(trifluoromethyl)benzyl]propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0597 0.3721
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0269 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0022 0.0126
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0764 0.0827
Onchocerca volvulus 0.011 0.0745 0.401
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0597 0.0585
Echinococcus multilocularis peregrin 0.0066 0.039 0.041
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0055 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0269 0.0269
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0115 0.079 0.0867
Leishmania major 4-coumarate:coa ligase-like protein 0.011 0.0745 0.0816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0055 0.0046
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0046 0.0235 0.0257
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.3039 0.328
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0084 0.0542 0.0594
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0597 0.3361
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0122 0.011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0122 0.011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0269 0.0279
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0057 0.0317 0.0348
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0172 0.0173
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0055 0.0055
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0234 0.1319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0066
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.0764 0.0838
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0764 0.8303
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0032 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0251 0.1412
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0059 0.0336 0.0351
Brugia malayi beta-lactamase 0.0112 0.0764 0.0764
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0269 0.0291
Mycobacterium tuberculosis Conserved protein 0.0112 0.0764 0.0838
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0048 0.0251 0.0271
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.0764 0.8303
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0745 0.0742
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0125 0.0125
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0269 0.0291
Trypanosoma cruzi ISWI complex protein 0.0031 0.0109 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0022 0.0126
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0055 0.0055
Onchocerca volvulus 0.0031 0.0108 0.0312
Loa Loa (eye worm) hypothetical protein 0.0022 0.004 0.0028
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0059 0.0051
Brugia malayi phosphofructokinase 0.0114 0.0783 0.0783
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0055 0.0055
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.011 0.0745 0.0742
Echinococcus multilocularis pyruvate kinase 0.0032 0.0122 0.0119
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0055 0.0043
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0396 0.0416
Entamoeba histolytica hypothetical protein 0.0212 0.1566 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0324 0.3448
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0783 0.0859
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0212 0.1566 0.1684
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0324 0.0338
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0269 0.0279
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0269 0.0279
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0783 0.4414
Schistosoma mansoni ap endonuclease 0.0038 0.0172 0.0186
Schistosoma mansoni hypothetical protein 0.0212 0.1566 0.1694
Brugia malayi CXXC zinc finger family protein 0.0028 0.0086 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0783 0.0848
Trypanosoma brucei polo-like protein kinase 0.0091 0.0597 0.6457
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0382 0.0401
Brugia malayi jmjC domain containing protein 0.0019 0.0012 0.0012
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0059 0.0051
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0057 0.0317 0.0317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Schistosoma mansoni hypothetical protein 0.0041 0.0195 0.0211
Loa Loa (eye worm) hypothetical protein 0.0112 0.0764 0.0753
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0324 0.3448
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0112 0.1102
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.013 0.0906 0.0969
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0018 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0015
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0234 0.2454
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0055 0.0059
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0597 0.0633
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0276 0.2085 0.2075
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0021 0.0032 0.0029
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.011 0.0745 0.0816
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0145 0.0159
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.1152 0.9119 1
Onchocerca volvulus 0.0112 0.0764 0.4122
Loa Loa (eye worm) hypothetical protein 0.0305 0.2318 0.2308
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0078 0.1301
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.0764 0.0838
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0783 0.0781
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0172 0.0173
Brugia malayi Pre-SET motif family protein 0.0209 0.1543 0.1543
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0783 0.0836
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0269 0.0269
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0035 0.0145 0.0144
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0115 0.079 0.0867
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0783 0.0848
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0112 0.1102
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0122 0.0689
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0055 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0269 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0215 0.2244
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0112 0.1102
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0137 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Schistosoma mansoni nuclear receptor 0.0024 0.0055 0.0059
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.036 0.3846
Toxoplasma gondii type I fatty acid synthase, putative 0.004 0.0186 0.1927
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0234 0.1319
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0269 0.0269
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.013 0.0906 0.0969
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0783 0.4931
Schistosoma mansoni hypothetical protein 0.028 0.2116 0.229
Onchocerca volvulus 0.0208 0.1535 0.8605
Echinococcus granulosus serine:threonine protein kinase SMG1 0.002 0.0022 0.0011
Onchocerca volvulus 0.0051 0.0272 0.1261
Loa Loa (eye worm) hypothetical protein 0.0066 0.0396 0.0384
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0172 0.0188
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0078 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0112 0.063
Loa Loa (eye worm) pyruvate kinase-PB 0.0022 0.0044 0.0032
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0783 1
Brugia malayi 6-phosphofructokinase 0.0114 0.0783 0.0783
Loa Loa (eye worm) Smad1 0.0024 0.0059 0.0047
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0112 0.058
Echinococcus granulosus pyruvate kinase 0.0032 0.0122 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Brugia malayi MH1 domain containing protein 0.0024 0.0059 0.0059
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0035 0.0145 0.0144
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.011 0.0745 0.0742
Brugia malayi nuclear receptor NHR-88 0.0051 0.0269 0.0269
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.011 0.0745 0.0794
Onchocerca volvulus 0.0238 0.1775 1
Schistosoma mansoni smad1 5 8 and 0.0024 0.0059 0.0064
Loa Loa (eye worm) hypothetical protein 0.0151 0.1078 0.1067
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0162 0.1169 0.1158
Leishmania major hypothetical protein, conserved 0.0112 0.0764 0.0838
Brugia malayi jmjC domain containing protein 0.0075 0.0465 0.0465
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0327 0.0354
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Plasmodium falciparum ataxin-2 like protein, putative 0.0131 0.0917 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0172 0.0173
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0172 0.0173
Schistosoma mansoni voltage-gated cation channel 0.0151 0.1078 0.1166
Leishmania major hypothetical protein, conserved 0.0131 0.0917 0.1006
Plasmodium vivax acetyl-CoA synthetase, putative 0.011 0.0745 0.8089
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0597 0.0646
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0151 0.1078 0.1155
Toxoplasma gondii hypothetical protein 0.0046 0.0235 0.2466
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0137 0.0136
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0212 0.1566 0.1684
Brugia malayi hypothetical protein 0.0024 0.0055 0.0055
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0327 0.0324
Schistosoma mansoni eyes absent homolog 0.0088 0.0573 0.062
Loa Loa (eye worm) oxidoreductase 0.011 0.0745 0.0733
Plasmodium falciparum ataxin-2 like protein, putative 0.0131 0.0917 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0022 0.0126
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0035 0.0145 0.0797
Mycobacterium ulcerans Type I modular polyketide synthase 0.0057 0.0317 0.0315
Trypanosoma brucei acetyl-CoA synthetase, putative 0.011 0.0745 0.8089
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0035 0.0145 0.0797
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0172 0.0172
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0048 0.0251 0.0259
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.006 0.0346 0.0379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0269 0.0257
Loa Loa (eye worm) hypothetical protein 0.0305 0.2318 0.2308
Schistosoma mansoni zinc finger protein 0.0024 0.0055 0.0059
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0055 0.0046
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0162 0.1169 0.1282
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0115 0.079 0.0788
Schistosoma mansoni hypothetical protein 0.013 0.0906 0.098
Schistosoma mansoni smad 0.0024 0.0059 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0764 0.0815
Loa Loa (eye worm) transcription factor SMAD2 0.0358 0.2737 0.2729
Echinococcus granulosus geminin 0.1055 0.8344 0.9028
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0396 0.0416
Schistosoma mansoni zinc finger protein 0.0031 0.0109 0.0118
Loa Loa (eye worm) hypothetical protein 0.011 0.0745 0.0733
Trypanosoma cruzi PAB1-binding protein , putative 0.0131 0.0917 0.0981
Loa Loa (eye worm) pigment dispersing factor receptor c 0.041 0.3159 0.3151
Echinococcus granulosus cpg binding protein 0.0033 0.013 0.0127
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0023 0.0047 0.0051
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0269 0.0291
Loa Loa (eye worm) hypothetical protein 0.0085 0.0545 0.0534
Leishmania major pyruvate kinase 0.0032 0.0122 0.0134
Loa Loa (eye worm) hypothetical protein 0.011 0.0745 0.0733
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.013 0.0906 0.0969
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0122 0.0393
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.1865 0.2008
Giardia lamblia GTOR 0.0035 0.0145 0.2435
Mycobacterium ulcerans thioesterase 0.0047 0.0242 0.0239
Mycobacterium tuberculosis Polyketide synthase Pks12 0.006 0.0346 0.0379
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.0863 0.0922
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0783 0.4931
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0057 0.0317 0.0315
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.011 0.0745 0.0742
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0269 0.0257
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0122 0.011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0465 0.0503
Echinococcus multilocularis GPCR, family 2 0.013 0.0906 0.0969
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0021 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.0112 0.0764 0.0753
Brugia malayi ecdysone receptor 0.0024 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0035 0.0145 0.0144
Schistosoma mansoni hypothetical protein 0.0395 0.3039 0.3289
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0041 0.0196 0.02
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0172 0.016
Brugia malayi Latrophilin receptor protein 2 0.013 0.0906 0.0906
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0055 0.0055
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0055 0.0046
Brugia malayi AF-10 protein 0.0019 0.0014 0.0014
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0032 0.0028
Mycobacterium tuberculosis Conserved protein 0.0112 0.0764 0.0838
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0055 0.0046
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0172 0.1765
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0764 0.4303
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0597 0.3361
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0597 0.0654
Echinococcus granulosus pyruvate kinase 0.0032 0.0122 0.0119
Plasmodium falciparum phd finger protein, putative 0.0057 0.0324 0.3448
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0396 0.0384
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0783 0.4414
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0112 0.1102
Mycobacterium ulcerans lipase LipD 0.0112 0.0764 0.0761
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0382 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0188 0.1373 0.1475
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0112 0.063
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.044 0.0464
Leishmania major 4-coumarate:coa ligase-like protein 0.011 0.0745 0.0816
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.2085 0.2256
Trypanosoma cruzi PAB1-binding protein , putative 0.0131 0.0917 0.0981
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0137 0.0148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0276 0.2085 0.2246
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0112 0.063
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0066
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.006 0.0346 0.0343
Loa Loa (eye worm) hypothetical protein 0.0141 0.0999 0.0989
Echinococcus granulosus AMP dependent ligase 0.0021 0.0032 0.0021
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.0764 0.0764
Echinococcus multilocularis long chain fatty acid transport protein 4 0.1167 0.9241 1
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0012 0.0013
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0055 0.0055
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0059 0.0064
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.006 0.0346 0.0373
Loa Loa (eye worm) hypothetical protein 0.0051 0.0269 0.0257
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.0764 0.0838
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0137 0.0136
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.0764 0.0815
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0172 0.0968
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0269 0.0279
Brugia malayi PHD-finger family protein 0.0055 0.0304 0.0304
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0035 0.0145 0.0157
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.0764 0.0753
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0269 0.0279
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0168 0.1727
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.1152 0.9119 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.011 0.0745 0.0816
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0465 0.0453
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0188 0.1373 0.1475
Loa Loa (eye worm) hypothetical protein 0.013 0.0906 0.0895
Schistosoma mansoni hypothetical protein 0.013 0.0906 0.098
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0597 0.3361
Trypanosoma brucei PAB1-binding protein , putative 0.0131 0.0917 1
Echinococcus granulosus voltage dependent calcium channel 0.0151 0.1078 0.1155
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0269 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Brugia malayi hypothetical protein 0.0085 0.0544 0.0544
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.011 0.0745 0.0794
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0055 0.0303 0.0333
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0032
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0078 0.0085
Echinococcus granulosus acetylcholinesterase 0.0066 0.0396 0.0416
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0269 0.0291
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0151 0.1078 0.1155
Brugia malayi hypothetical protein 0.0027 0.0078 0.0078
Onchocerca volvulus Alhambra homolog 0.0057 0.0324 0.1567
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0122 0.0122
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0151 0.1078 0.1155
Loa Loa (eye worm) fatty acid synthase 0.0056 0.0311 0.03
Brugia malayi AMP-binding enzyme family protein 0.011 0.0745 0.0745
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0327 0.0359
Mycobacterium ulcerans Type I modular polyketide synthase 0.0057 0.0317 0.0315
Echinococcus granulosus acetylcholinesterase 0.0066 0.0396 0.0416
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0115 0.079 0.0788
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0051 0.0269 0.0257
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0465 0.0503
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0055 0.0059
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.0863 0.0922
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0226 0.1275
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.011 0.0745 0.8089
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0055 0.0047
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0783 0.0772
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0745 0.0742
Echinococcus granulosus Smad4 0.0024 0.0059 0.0051
Schistosoma mansoni FFA transport protein 0.1167 0.9241 1
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0078 0.0724
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.011 0.0745 0.0811
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0168 0.0947
Plasmodium vivax ataxin-2 like protein, putative 0.0131 0.0917 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Echinococcus granulosus voltage dependent calcium channel 0.0053 0.0286 0.0297
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.1167 0.9241 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0057 0.0317 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0122 0.0119
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0783 0.0836
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0122 0.1217
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0251 0.0251
Trypanosoma cruzi ISWI complex protein 0.0031 0.0109 0.0105
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0055 0.0059
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.011 0.0745 0.0742
Leishmania major phosphatidylinositol 3-kinase, putative 0.0035 0.0145 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0269 0.0257
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0269 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Entamoeba histolytica acyl-CoA synthetase, putative 0.0115 0.079 0.4976
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0112 0.063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0276 0.2085 0.2246
Schistosoma mansoni survival motor neuron protein 0.0051 0.0272 0.0294
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0115 0.079 0.0861
Brugia malayi beta-lactamase family protein 0.0112 0.0764 0.0764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0269 0.0257
Schistosoma mansoni cpg binding protein 0.0028 0.0086 0.0093
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0078 0.0084
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1034 0.1034
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0269 0.0269
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0122 0.0134
Brugia malayi hypothetical protein 0.0131 0.0917 0.0917
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0014 0.0021
Onchocerca volvulus 0.0162 0.1169 0.6477
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0078 0.0724
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0014 0.0021
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0115 0.079 0.0867
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0172 0.0969
Schistosoma mansoni jumonji domain containing protein 0.0149 0.1063 0.115
Echinococcus multilocularis geminin 0.1055 0.8344 0.9028
Brugia malayi AMP-binding enzyme family protein 0.011 0.0745 0.0745
Mycobacterium ulcerans beta-lactamase 0.0112 0.0764 0.0761
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.0764 0.0838
Brugia malayi hypothetical protein 0.0088 0.0573 0.0573
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.0764 0.0838
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0382 0.0414
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0122 0.1217
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.011 0.0745 0.0742
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0145 0.1472
Loa Loa (eye worm) carboxylesterase 0.0066 0.0396 0.0384
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0269 0.0257
Leishmania major pyruvate kinase 0.0032 0.0122 0.0134
Loa Loa (eye worm) hypothetical protein 0.0077 0.048 0.0468
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0172 0.0169
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0017 0.0003 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0269 0.0279
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0238 0.0245
Brugia malayi MH2 domain containing protein 0.0024 0.0059 0.0059
Brugia malayi Carboxylesterase family protein 0.0066 0.0396 0.0396
Brugia malayi hypothetical protein 0.0249 0.1865 0.1865
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0745 0.0742
Loa Loa (eye worm) hypothetical protein 0.0051 0.0269 0.0257
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0745 0.0742
Echinococcus multilocularis pyruvate kinase 0.0025 0.0068 0.006
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0112 0.1102
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.002 0.0022 0.0011
Loa Loa (eye worm) hypothetical protein 0.0112 0.0764 0.0753
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0597 0.3361
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0055 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.011 0.0745 0.0816
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0022 0.004 0.0314
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.011 0.0745 0.0816
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0745 0.0742
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.044 0.0464
Loa Loa (eye worm) hypothetical protein 0.0112 0.0764 0.0753
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0269 0.1246
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0066
Entamoeba histolytica hypothetical protein 0.0048 0.0251 0.1479
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0086 0.0074
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0122 0.1217
Trichomonas vaginalis antibiotic synthetase, putative 0.011 0.0745 0.4194
Loa Loa (eye worm) hypothetical protein 0.0057 0.0324 0.0313
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0055 0.0303 0.0333
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0234 0.0241
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0122 0.0119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0055 0.0046
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0078 0.0358
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0238 0.0258
Brugia malayi hypothetical protein 0.0024 0.0055 0.0055
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0055 0.0055
Mycobacterium ulcerans hypothetical protein 0.011 0.0745 0.0742
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0057 0.0317 0.0348
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0055 0.0043
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0037 0.0158 0.161
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0035 0.0146 0.0145
Schistosoma mansoni zinc finger protein 0.0044 0.0218 0.0236
Entamoeba histolytica hypothetical protein 0.0212 0.1566 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.004 0.0228
Schistosoma mansoni hypothetical protein 0.013 0.0906 0.098
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0172 0.5
Echinococcus multilocularis jumonji domain containing protein 0.008 0.0505 0.0534
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0035 0.0145 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0269 0.0269
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0783 0.4931
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0597 0.3361
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0108 0.0117
Brugia malayi nuclear receptor RXR 0.0024 0.0055 0.0055
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0783 0.0772
Entamoeba histolytica acyl-CoA synthetase, putative 0.011 0.0745 0.4679
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0035 0.0145 0.0144
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0112 0.063
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.013 0.0906 0.0906
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0269 0.0257
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0172 0.2879
Brugia malayi Pre-SET motif family protein 0.0031 0.0108 0.0108
Echinococcus granulosus serine protein kinase ATM 0.0048 0.0251 0.0259
Schistosoma mansoni flap endonuclease-1 0.0024 0.0057 0.0062
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0172 0.1765
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0122 0.0122
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0238 0.0245
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0327 0.0359
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0296 0.0284
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0035 0.0145 0.0159
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0078 0.0066
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0122 0.1217
Loa Loa (eye worm) hypothetical protein 0.0032 0.0122 0.011
Leishmania major hypothetical protein, conserved 0.0031 0.0109 0.012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0382 0.0414
Mycobacterium tuberculosis Probable thioesterase TesA 0.0047 0.0242 0.0265
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0078 0.0724
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0045
Mycobacterium ulcerans fatty acid synthase Fas 0.0018 0.0006 0.0003
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0055 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0764 0.0815
Echinococcus multilocularis AMP dependent ligase 0.0021 0.0032 0.0021
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0269 0.0291
Trypanosoma brucei ISWI complex protein 0.0031 0.0109 0.1071
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0059 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Brugia malayi Smad1 0.0024 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Leishmania major acetyl-CoA synthetase, putative 0.011 0.0745 0.0816
Toxoplasma gondii FATC domain-containing protein 0.0048 0.0251 0.2635
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.011 0.0745 0.0794
Brugia malayi nuclear receptor NHR-88 0.0024 0.0055 0.0055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0276 0.2085 0.2246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0048 0.0251 0.2635
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0597 0.0633
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0269 0.1246
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0078 0.0437
Schistosoma mansoni ap endonuclease 0.0038 0.0172 0.0186
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0597 0.0633
Echinococcus multilocularis serine protein kinase ATM 0.0048 0.0251 0.0259
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0107 0.0724 0.0724
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0057 0.0317 0.0348
Mycobacterium leprae Probable lipase LipE 0.0112 0.0764 0.0832
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0269 0.0269
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0269 0.0279
Onchocerca volvulus 0.0119 0.0822 0.4458
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0764 0.4303
Loa Loa (eye worm) beta-lactamase 0.0112 0.0764 0.0753
Mycobacterium tuberculosis Conserved protein 0.0112 0.0764 0.0838
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0045 0.0229 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Schistosoma mansoni transcription factor LCR-F1 0.0212 0.1566 0.1694
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0045 0.0229 0.0226
Brugia malayi beta-lactamase family protein 0.0112 0.0764 0.0764
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.006 0.0346 0.0373
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0035 0.0145 0.1472
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0783 0.0836
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0078 0.0071
Leishmania major fatty acid transporter protein-like protein 0.1152 0.9119 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0286 0.0275
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0269 0.0279
Schistosoma mansoni hypothetical protein 0.0051 0.0272 0.0294
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0276 0.2085 0.2246
Schistosoma mansoni hypothetical protein 0.013 0.0906 0.098
Loa Loa (eye worm) DR-78 0.0024 0.0055 0.0043
Brugia malayi Calcitonin receptor-like protein seb-1 0.041 0.3159 0.3159
Onchocerca volvulus 0.0051 0.0269 0.1246
Mycobacterium ulcerans thioesterase TesA 0.0047 0.0242 0.0239
Loa Loa (eye worm) hypothetical protein 0.0112 0.0764 0.0753
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0115 0.079 0.0788
Echinococcus granulosus flap endonuclease 1 0.0027 0.0078 0.0071
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0269 0.0257
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0269 0.0291
Brugia malayi acetyl-Coenzyme A synthetase 2 0.011 0.0745 0.0745
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.011 0.0745 0.0816
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0055 0.0043
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0597 0.0633
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.1261 1 1
Brugia malayi jmjC domain containing protein 0.0019 0.0012 0.0012
Brugia malayi PHD-finger family protein 0.0057 0.0324 0.0324
Loa Loa (eye worm) acyl carrier protein 0.0026 0.0072 0.006
Brugia malayi 6-phosphofructokinase 0.0114 0.0783 0.0783
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0226 0.1275
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0172 0.0968
Loa Loa (eye worm) hypothetical protein 0.011 0.0745 0.0733
Brugia malayi tailless protein 0.0024 0.0055 0.0055
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0059 0.0047
Toxoplasma gondii exonuclease III APE 0.0038 0.0172 0.1765
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0324 0.3448
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0597 0.3361
Brugia malayi AMP-binding enzyme family protein 0.011 0.0745 0.0745
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.0764 0.0815
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0276 0.2085 0.2085
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0035 0.0145 0.1472
Mycobacterium ulcerans fatty-acid-CoA ligase 0.011 0.0745 0.0742
Loa Loa (eye worm) hypothetical protein 0.0051 0.0269 0.0257
Brugia malayi MH1 domain containing protein 0.0024 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.1055 0.8344 0.9029
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.011 0.0745 0.0816
Onchocerca volvulus Fatty acid synthase homolog 0.0102 0.0682 0.3646
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.004 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0249 0.1865 0.1855
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.011 0.0745 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0055 0.0046
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0122 0.0122
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0055 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0269 0.0269
Schistosoma mansoni nuclear receptor 0.0024 0.0055 0.0059
Loa Loa (eye worm) hypothetical protein 0.0098 0.0654 0.0642
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0269 0.0291
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0078 0.0071
Onchocerca volvulus 0.0112 0.0764 0.4122
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0041 0.0189 0.0208
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0095 0.009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0269 0.0291
Brugia malayi PHD-finger family protein 0.0024 0.0057 0.0057
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0115 0.079 0.0788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.0764 0.0761
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0234 0.2454
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.011 0.0745 0.0811
Leishmania major pantothenate kinase subunit, putative 0.0023 0.0048 0.0053
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0014 0.0021
Chlamydia trachomatis pyruvate kinase 0.0032 0.0122 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.0815 0.0804
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0269 0.1246
Schistosoma mansoni pyruvate kinase 0.0032 0.0122 0.0132
Giardia lamblia Pyruvate kinase 0.0032 0.0122 0.2048
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0269 0.0279
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.011 0.0745 0.0816
Echinococcus granulosus smad 0.0024 0.0059 0.0051
Echinococcus granulosus long chain fatty acid transport protein 4 0.1167 0.9241 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.013 0.0906 0.0895
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0035 0.0145 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.2085 0.2256
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0078 0.0085
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0272 0.0272
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.011 0.0745 0.0794
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0108 0.0104
Echinococcus multilocularis cpg binding protein 0.0033 0.013 0.0127
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0421 0.0443
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0078 0.0071
Toxoplasma gondii LsmAD domain-containing protein 0.0131 0.0917 1
Brugia malayi MH2 domain containing protein 0.0024 0.0059 0.0059
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.1167 0.9241 1
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0122 0.0119
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0032 0.006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0964 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Brugia malayi AMP-binding enzyme family protein 0.011 0.0745 0.0745
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0115 0.079 0.079
Schistosoma mansoni kinase 0.0046 0.0236 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0269 0.0269
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0145 0.0133
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0057 0.0317 0.0342
Brugia malayi jmjC domain containing protein 0.0019 0.0012 0.0012
Plasmodium vivax hypothetical protein, conserved 0.002 0.0027 0.0171
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0783 0.8519
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0396 0.0429
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0269 0.0291
Schistosoma mansoni smad1 5 8 and 0.0024 0.0059 0.0064
Schistosoma mansoni hypothetical protein 0.1055 0.8344 0.9029
Mycobacterium ulcerans polyketide synthase 0.0057 0.0317 0.0315
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0106
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0035 0.0145 0.0144
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0783 0.0853
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.004 0.0228
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0145 0.0144
Brugia malayi MH2 domain containing protein 0.0358 0.2737 0.2737
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0122 0.0128
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Plasmodium falciparum pyruvate kinase 0.0032 0.0122 0.1217
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0066
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0172 0.0188
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0012 0.0013
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0112 0.1874
Mycobacterium leprae Probable polyketide synthase Pks1 0.006 0.0346 0.0373
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0269 0.0269
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0151 0.1078 0.1166
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0022 0.0126
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0327 0.0341
Loa Loa (eye worm) hypothetical protein 0.0041 0.0196 0.0185
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.002 0.0027 0.0171
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0078 0.0066
Loa Loa (eye worm) hypothetical protein 0.0046 0.0235 0.0224
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0122 0.0393
Leishmania major phosphatidylinositol kinase related protein, putative 0.0035 0.0146 0.016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.006 0.0346 0.0343
Entamoeba histolytica pyruvate kinase, putative 0.0022 0.0044 0.014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0269 0.0279
Brugia malayi nuclear receptor NHR-67 0.0024 0.0055 0.0055
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0035 0.0145 0.1472
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.0465 0.049
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.006 0.0346 0.0379
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0035 0.0145 0.0159
Echinococcus multilocularis muscleblind protein 1 0.0305 0.2318 0.2498
Brugia malayi Bromodomain containing protein 0.0066 0.039 0.039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0145 0.0145
Echinococcus granulosus zinc finger protein 0.0044 0.0218 0.0223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.2085 0.2256
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0023 0.0048 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0269 0.0269
Brugia malayi conserved hypotetical protein 0.0024 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0022 0.0126
Loa Loa (eye worm) acetyltransferase 0.0146 0.1034 0.1023
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0151 0.1078 0.1155
Loa Loa (eye worm) hypothetical protein 0.0088 0.0573 0.0561
Mycobacterium ulcerans hypothetical protein 0.0112 0.0764 0.0761
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0037 0.0164 0.0173
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0035 0.0145 0.0144
Loa Loa (eye worm) hypothetical protein 0.011 0.0745 0.0733
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0059 0.0336 0.0351
Brugia malayi nuclear receptor RXR 0.0027 0.0078 0.0078
Echinococcus granulosus jumonji domain containing protein 0.008 0.0505 0.0534
Mycobacterium leprae conserved hypothetical protein 0.0112 0.0764 0.0832
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.002 0.0022 0.0011
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.011 0.0745 0.0811
Loa Loa (eye worm) hypothetical protein 0.011 0.0749 0.0737
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.001
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0151 0.1078 0.1078
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0327 0.0341
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.011 0.0745 0.4679
Schistosoma mansoni smad1 5 8 and 0.0024 0.0059 0.0064
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0053 0.0286 0.303
Echinococcus granulosus muscleblind protein 0.0305 0.2318 0.2498
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1034 0.1118
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0145 0.1472
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0108 0.1064
Schistosoma mansoni hypothetical protein 0.0031 0.0109 0.0118
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0764 0.4303
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.011 0.0745 0.0816
Schistosoma mansoni Smad4 0.0024 0.0059 0.0064
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0078 0.0078
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0151 0.1078 0.1155
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.011 0.0745 0.8089
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0745 0.0742
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0324 0.0351
Echinococcus multilocularis zinc finger protein 0.0044 0.0218 0.0223
Toxoplasma gondii type I fatty acid synthase, putative 0.0075 0.0468 0.5036
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0053 0.0286 0.0297
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0035 0.0145 0.0144
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0078 0.0078
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.011 0.0745 0.0811
Loa Loa (eye worm) hypothetical protein 0.0051 0.0269 0.0257
Loa Loa (eye worm) hypothetical protein 0.011 0.0745 0.0733
Brugia malayi steroid hormone receptor 0.0051 0.0269 0.0269
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0078 0.0084
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0172 0.1765
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0055 0.0047
Plasmodium falciparum acetyl-CoA synthetase, putative 0.011 0.0745 0.8089
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1034 0.1107
Loa Loa (eye worm) hypothetical protein 0.0051 0.0269 0.0257
Mycobacterium ulcerans polyketide synthase 0.006 0.0346 0.0343
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0151 0.1078 0.1155
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0235 0.0224
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0783 0.0859
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0345 0.0373
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0745 0.0742
Plasmodium falciparum flap endonuclease 1 0.0027 0.0078 0.0724
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.0764 0.0838
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.011 0.0745 0.8089
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0151 0.1078 0.1166
Giardia lamblia Kinase, PLK 0.0091 0.0597 1
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0269 0.0279
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.013 0.0906 0.0969
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0084 0.0542 0.0594
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0122 0.0393
Entamoeba histolytica hypothetical protein 0.0212 0.1566 1
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0122 0.0689
Loa Loa (eye worm) hypothetical protein 0.0088 0.0573 0.0561
Onchocerca volvulus 0.011 0.0745 0.401
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0269 0.0291
Brugia malayi jmjC domain containing protein 0.0019 0.0012 0.0012
Toxoplasma gondii transporter, cation channel family protein 0.0053 0.0286 0.303
Loa Loa (eye worm) calcium channel 0.0151 0.1078 0.1067
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0327 0.0324
Loa Loa (eye worm) hypothetical protein 0.0066 0.0396 0.0384
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0234 0.2454
Loa Loa (eye worm) hypothetical protein 0.041 0.3159 0.3151
Mycobacterium ulcerans Type I modular polyketide synthase 0.0057 0.0317 0.0315
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0055 0.0059
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0047 0.0242 0.0259
Brugia malayi nuclear hormone receptor 0.0051 0.0269 0.0269
Brugia malayi Flap endonuclease-1 0.0027 0.0078 0.0078
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0035 0.0145 0.0159
Loa Loa (eye worm) hypothetical protein 0.0112 0.0764 0.0753
Leishmania major acetyl-CoA synthetase, putative 0.011 0.0745 0.0816
Mycobacterium leprae Polyketide synthase Pks13 0.0084 0.0542 0.0588
Echinococcus granulosus dnaJ subfamily B 0.0395 0.3039 0.328
Brugia malayi AMP-binding enzyme family protein 0.011 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.009 0.0589 0.0577
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1543 0.1533
Echinococcus granulosus peregrin 0.0066 0.039 0.041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0055 0.0046
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0059 0.0047
Schistosoma mansoni bromodomain containing protein 0.0132 0.092 0.0996
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0269 0.0269
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0597 0.0597
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.1865 0.2008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0835 0.6578 0.7114
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0745 0.0742
Brugia malayi Carboxylesterase family protein 0.0066 0.0396 0.0396
Plasmodium vivax SET domain protein, putative 0.0031 0.0108 0.1064
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0783 0.4414
Schistosoma mansoni fkbp-rapamycin associated protein 0.002 0.0022 0.0024
Entamoeba histolytica hypothetical protein 0.0212 0.1566 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0917 0.0907
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0012 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.011 0.0745 0.0816
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0151 0.1078 0.1155
Loa Loa (eye worm) MH2 domain-containing protein 0.0358 0.2737 0.2729
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0597 0.3151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Mycobacterium ulcerans polyketide synthase Pks13 0.0084 0.0542 0.0539
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0764 0.0827
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.0764 0.0838
Loa Loa (eye worm) hypothetical protein 0.0065 0.0382 0.0371
Onchocerca volvulus 0.0112 0.0764 0.4122
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0035 0.0145 0.1472
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0168 0.2823
Onchocerca volvulus 0.0028 0.0086 0.0183
Entamoeba histolytica acyl-coA synthetase, putative 0.011 0.0745 0.4679
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0145 0.0145
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0108 0.0117
Brugia malayi Bromodomain containing protein 0.008 0.0506 0.0506
Brugia malayi hypothetical protein 0.0212 0.1566 0.1566
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.011 0.0745 0.0794
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0764 0.4303
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0175 0.0163
Toxoplasma gondii ABC1 family protein 0.0112 0.0764 0.8303
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0269 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Schistosoma mansoni acetyl-CoA synthetase 0.011 0.0745 0.0806
Schistosoma mansoni coup transcription factor 0.0051 0.0269 0.0291
Toxoplasma gondii propionate-CoA ligase 0.011 0.0745 0.8089
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0112 0.063
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0269 0.0279
Mycobacterium ulcerans acyl-CoA synthetase 0.0115 0.079 0.0788
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0269 0.0269
Brugia malayi latrophilin 2 splice variant baaae 0.028 0.2116 0.2116
Echinococcus multilocularis muscleblind protein 0.0305 0.2318 0.2498
Brugia malayi hypothetical protein 0.0027 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0051 0.0269 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0022 0.0126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0269 0.0279
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0597 0.3361
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0195 0.0183
Schistosoma mansoni hypothetical protein 0.0059 0.0336 0.0364
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0783 0.4414
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0032 0.0121 0.0133
Leishmania major hypothetical protein, conserved 0.0019 0.0012 0.0013
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.011 0.0745 0.0794
Mycobacterium ulcerans polyketide synthase Pks9 0.0037 0.0164 0.0161
Brugia malayi jmjC domain containing protein 0.0188 0.1373 0.1373
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0059 0.0051
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0172 0.0893
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0037 0.0164 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0269 0.0257
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0396 0.0416
Schistosoma mansoni cpg binding protein 0.0033 0.013 0.014
Schistosoma mansoni hypothetical protein 0.0057 0.0324 0.0351
Brugia malayi ecdysteroid receptor 0.0051 0.0269 0.0269
Trichomonas vaginalis esterase, putative 0.0112 0.0764 0.4303
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0115 0.079 0.0867
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0716 0.5617 0.616
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0269 0.0279
Brugia malayi nuclear hormone receptor 0.0024 0.0055 0.0055
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0269 0.0279
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0764 0.4303
Echinococcus multilocularis smad 0.0024 0.0059 0.0051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.041 0.3159 0.3159
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0045 0.0229 0.0244
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0043
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0012 0.0013
Loa Loa (eye worm) AMP-binding enzyme family protein 0.1261 1 1
Schistosoma mansoni cpg binding protein 0.0033 0.013 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Schistosoma mansoni pyruvate kinase 0.0032 0.0122 0.0132
Echinococcus multilocularis pyruvate kinase 0.0032 0.0122 0.0119
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.0622 0.0682
Brugia malayi Muscleblind-like protein 0.0305 0.2318 0.2318
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0745 0.0742
Loa Loa (eye worm) hypothetical protein 0.0051 0.0269 0.0257
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0269 0.0279
Trichomonas vaginalis antibiotic synthetase, putative 0.011 0.0745 0.4194
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0327 0.0327
Mycobacterium ulcerans acetyl-CoA synthetase 0.011 0.0745 0.0742
Brugia malayi Bromodomain containing protein 0.0155 0.1109 0.1109
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0112 0.063
Echinococcus multilocularis voltage dependent calcium channel 0.0151 0.1078 0.1155
Echinococcus granulosus GPCR family 2 0.013 0.0906 0.0969
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0269 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Echinococcus multilocularis Smad4 0.0024 0.0059 0.0051
Loa Loa (eye worm) voltage-dependent calcium channel 0.0053 0.0286 0.0275
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.0764 0.0761
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0783 0.0772
Loa Loa (eye worm) hypothetical protein 0.028 0.2116 0.2107
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0055 0.0046
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0019 0.0019 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0269 0.0269
Leishmania major 4-coumarate:coa ligase-like protein 0.011 0.0745 0.0816
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0145 0.0133
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0396 0.0416
Brugia malayi AMP-binding enzyme family protein 0.0162 0.1169 0.1169
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0112 0.1102
Mycobacterium ulcerans acyl-CoA synthetase 0.011 0.0745 0.0742
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0012 0.0013
Echinococcus multilocularis voltage dependent calcium channel 0.0151 0.1078 0.1155
Giardia lamblia PHD finger protein 15 0.0057 0.0324 0.5435
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0324 0.0313
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0022 0.0126
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0324 0.0338
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1775 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0145 0.0818
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0112 0.1102

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 6 % Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM ChEMBL. 17326615
Inhibition (binding) = 6 % Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM ChEMBL. 17326615
Inhibition (binding) = 55 % Inhibition of pig kidney microsomal APN at 10 uM ChEMBL. 17326615
Inhibition (binding) = 55 % Inhibition of pig kidney microsomal APN at 10 uM ChEMBL. 17326615

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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