Detailed information for compound 45899

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 634.684 | Formula: C34H34N8O5
  • H donors: 3 H acceptors: 7 LogP: 3.18 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(OCc1ccccc1)CCC(C(=O)OCc1ccccc1)NC(=O)c1ccc(cc1)N(Cc1cnc2c(n1)c(N)nc(n2)N)C
  • InChi: 1S/C34H34N8O5/c1-42(19-25-18-37-31-29(38-25)30(35)40-34(36)41-31)26-14-12-24(13-15-26)32(44)39-27(33(45)47-21-23-10-6-3-7-11-23)16-17-28(43)46-20-22-8-4-2-5-9-22/h2-15,18,27H,16-17,19-21H2,1H3,(H,39,44)(H4,35,36,37,40,41)
  • InChiKey: VQIPKIZPEATZLC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0111 0.0227 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0111 0.0227 0.0227
Brugia malayi Smad1 0.0111 0.0227 0.0227
Echinococcus multilocularis beta tubulin 0.409 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.048 0.1135 0.1135
Echinococcus multilocularis muscleblind protein 0.03 0.0692 0.0692
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0022 0.0019
Echinococcus multilocularis beta tubulin 0.409 1 1
Leishmania major hypothetical protein, conserved 0.0037 0.0047 0.0047
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0047 0.0047
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0264 0.0605 0.0597
Schistosoma mansoni smad1 5 8 and 0.0111 0.0227 0.0227
Trypanosoma brucei epsilon tubulin 0.218 0.5309 0.5309
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0002
Plasmodium falciparum alpha tubulin 1 0.2967 0.7242 0.7239
Brugia malayi nuclear hormone receptor family member odr-7 0.0047 0.0071 0.0071
Loa Loa (eye worm) CBP-B 0.008 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0047 0.0046
Echinococcus multilocularis tubulin alpha chain 0.2967 0.7242 0.7242
Brugia malayi nuclear receptor RXR 0.0063 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0156 0.0338 0.0338
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0024 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0227
Brugia malayi tubulin alpha chain - mouse 0.2967 0.7242 0.7242
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0024 0.0015 0.0015
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0022 0.0009 0.0009
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0047 0.0205
Echinococcus granulosus Tubulin beta 2C chain 0.409 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0022 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0111 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0063 0.0111 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0428 0.0428
Loa Loa (eye worm) alpha-tubulin 0.2967 0.7242 0.7242
Trichomonas vaginalis conserved hypothetical protein 0.0946 0.228 0.2279
Echinococcus granulosus mothers against decapentaplegic 5 0.0111 0.0227 0.0227
Brugia malayi MH2 domain containing protein 0.0049 0.0077 0.0077
Leishmania major beta tubulin 0.409 1 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0541 0.1285 0.1284
Echinococcus multilocularis tubulin alpha 3 chain 0.2967 0.7242 0.7242
Plasmodium vivax glutathione reductase, putative 0.0049 0.0075 0.0067
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0048 0.0048
Leishmania major alpha tubulin 0.2967 0.7242 0.7242
Loa Loa (eye worm) MH1 domain-containing protein 0.0111 0.0227 0.0227
Plasmodium falciparum tubulin gamma chain 0.218 0.5309 0.5305
Brugia malayi Nuclear hormone receptor E75 0.0047 0.0071 0.0071
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0946 0.228 0.2279
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0015 0.0015
Brugia malayi hypothetical protein 0.0265 0.0606 0.0606
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0045 0.0066 0.0292
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0111 0.0227 0.0227
Trichomonas vaginalis tubulin epsilon chain, putative 0.0946 0.228 0.2279
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.003 0.003
Schistosoma mansoni zinc finger protein 0.0047 0.0071 0.0071
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0001 0.0001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0075 0.0075
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0047 0.0071 0.0071
Echinococcus granulosus ecdysone induced protein 78C 0.0111 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0227
Mycobacterium ulcerans hypothetical protein 0.0021 0.0007 0.0029
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0231 0.0229
Brugia malayi MH2 domain containing protein 0.0111 0.0227 0.0227
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.0428 0.0428
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0015 0.0015
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0001 0.0001
Schistosoma mansoni brca1-associated protein (brap2) 0.0024 0.0015 0.0015
Loa Loa (eye worm) histone deacetylase 7A 0.0297 0.0686 0.0686
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0264 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0099 0.02 0.02
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0001 0.0001
Echinococcus granulosus histone deacetylase 3 0.0541 0.1285 0.1285
Toxoplasma gondii beta-tubulin, putative 0.409 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0001 0.0001
Echinococcus granulosus GPCR family 2 0.0031 0.0032 0.0032
Schistosoma mansoni tubulin subunit beta 0.0946 0.228 0.228
Trichomonas vaginalis tubulin gamma chain, putative 0.218 0.5309 0.5308
Leishmania major alpha tubulin 0.2967 0.7242 0.7242
Schistosoma mansoni histone deacetylase 1 2 3 0.0188 0.0417 0.0417
Entamoeba histolytica hypothetical protein 0.0487 0.1151 0.1149
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0111 0.0227 0.0227
Echinococcus multilocularis FTZ F1 alpha 0.0111 0.0227 0.0227
Plasmodium falciparum glutathione reductase 0.0049 0.0075 0.0067
Echinococcus granulosus intermediate filament protein 0.0054 0.0089 0.0089
Brugia malayi Tubulin alpha-2 chain 0.2967 0.7242 0.7242
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0264 0.0605 0.0605
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0111 0.0227 0.0227
Plasmodium falciparum histone deacetylase 1 0.0541 0.1285 0.1277
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Plasmodium vivax histone deacetylase 1, putative 0.0541 0.1285 0.1277
Brugia malayi Histone deacetylase 1 0.0541 0.1285 0.1285
Brugia malayi intermediate filament protein 0.0054 0.0089 0.0089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0111 0.0227 0.0227
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0065 0.0116 0.0116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0111 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Schistosoma mansoni histone deacetylase hda2 0.0321 0.0745 0.0745
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0032 0.0032
Loa Loa (eye worm) cytochrome P450 family protein 0.0076 0.0142 0.0142
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0002 0.0002
Leishmania major beta tubulin 0.409 1 1
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0059 0.01 0.01
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0063 0.0111 0.0111
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0024 0.0015 0.0006
Leishmania major beta tubulin 0.409 1 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0048 0.0048
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0047 0.0205
Mycobacterium tuberculosis Conserved protein 0.0037 0.0047 0.0205
Echinococcus multilocularis histone deacetylase 1 0.0541 0.1285 0.1285
Loa Loa (eye worm) histone deacetylase 0.0297 0.0686 0.0686
Loa Loa (eye worm) beta-tubulin 0.409 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0063 0.0111 0.0111
Brugia malayi histone deacetylase 3 (HD3) 0.0541 0.1285 0.1285
Schistosoma mansoni hypothetical protein 0.0119 0.0247 0.0247
Brugia malayi CXXC zinc finger family protein 0.003 0.0028 0.0028
Leishmania major trypanothione reductase 0.0049 0.0075 0.0075
Brugia malayi Nuclear hormone receptor-like 1 0.0063 0.0111 0.0111
Onchocerca volvulus 0.0775 0.186 0.623
Echinococcus multilocularis hypothetical protein 0.2967 0.7242 0.7242
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0032 0.0035 0.0152
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0047 0.0047
Brugia malayi histone deacetylase 11 0.0188 0.0417 0.0417
Echinococcus multilocularis neuropeptide s receptor 0.048 0.1135 0.1135
Mycobacterium tuberculosis Hypothetical protein 0.0053 0.0085 0.0373
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0001 0.0001
Schistosoma mansoni tubulin subunit beta 0.409 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0002 0.0009
Entamoeba histolytica tubulin alpha-1 chain 0.2967 0.7242 0.7241
Mycobacterium leprae cell division protein FtsZ 0.0946 0.228 1
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.003 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0015 0.0015
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0001 0.0001
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0001 0.0001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0111 0.0227 0.0227
Plasmodium falciparum histone deacetylase 2 0.0297 0.0686 0.0678
Entamoeba histolytica DNA topoisomerase II, putative 0.0065 0.0116 0.0114
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.003 0.0094
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0075 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0047 0.0071 0.0071
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0047 0.0047
Mycobacterium ulcerans DNA gyrase subunit B 0.0022 0.0009 0.0038
Echinococcus multilocularis lamin 0.0054 0.0089 0.0089
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0029
Trichomonas vaginalis esterase, putative 0.0037 0.0047 0.0046
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0001 0.0001
Echinococcus granulosus thyroid hormone receptor alpha 0.0047 0.0071 0.0071
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0048 0.0048
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0024 0.0015 0.0006
Schistosoma mansoni tubulin subunit alpha 0.2967 0.7242 0.7242
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0228 0.1002
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0001 0.0001
Echinococcus granulosus BRCA1 associated protein 0.0024 0.0015 0.0015
Plasmodium vivax DNA topoisomerase II, putative 0.0065 0.0116 0.0108
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0062 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Onchocerca volvulus 0.032 0.0741 0.2478
Echinococcus granulosus tubulin alpha 3 chain 0.2967 0.7242 0.7242
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0047 0.0046
Trypanosoma brucei alpha tubulin 0.2967 0.7242 0.7242
Leishmania major beta tubulin 0.409 1 1
Onchocerca volvulus 0.0037 0.0047 0.0152
Echinococcus multilocularis nuclear receptor nhr 48 0.0047 0.0071 0.0071
Plasmodium falciparum ataxin-2 like protein, putative 0.0265 0.0606 0.0598
Brugia malayi Probable isocitrate dehydrogenase 0.0032 0.0035 0.0035
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0022 0.0022
Mycobacterium ulcerans beta-lactamase 0.0037 0.0047 0.0205
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0196 0.0196
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0113 0.0113
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.015 0.0148
Echinococcus multilocularis mothers against decapentaplegic 2 0.0049 0.0077 0.0077
Trypanosoma brucei alpha tubulin 0.2967 0.7242 0.7242
Brugia malayi 6-phosphofructokinase 0.0112 0.0231 0.0231
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0001 0.0001
Echinococcus granulosus alpha tubulin 0.2967 0.7242 0.7242
Echinococcus multilocularis tubulin alpha chain 0.2967 0.7242 0.7242
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0001 0.0001
Brugia malayi Cytochrome P450 family protein 0.0076 0.0142 0.0142
Trypanosoma cruzi beta tubulin, putative 0.409 1 1
Brugia malayi Isocitrate dehydrogenase 0.0264 0.0605 0.0605
Echinococcus multilocularis histone deacetylase 6 0.0297 0.0686 0.0686
Brugia malayi Flap endonuclease-1 0.0027 0.0022 0.0022
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0231 0.0231
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.0231 0.0977
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0001 0.0001
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0007 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0047 0.0038
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0231 0.0231
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0132 0.0132
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0029
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0047 0.0047
Echinococcus granulosus lamin 0.0054 0.0089 0.0089
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0264 0.0605 0.0605
Echinococcus granulosus histone deacetylase 8 0.0188 0.0417 0.0417
Trichomonas vaginalis tubulin beta chain, putative 0.2967 0.7242 0.7241
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0035
Echinococcus granulosus lamin dm0 0.0054 0.0089 0.0089
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0001 0.0001
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0001 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0231 0.023
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0001 0.0001
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0264 0.0605 0.0605
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0047 0.0072 0.0238
Trichomonas vaginalis tubulin beta chain, putative 0.2967 0.7242 0.7241
Schistosoma mansoni nAChR subunit 0.0019 0.0001 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0063 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Mycobacterium tuberculosis Conserved protein 0.0037 0.0047 0.0205
Brugia malayi hypoxia-induced factor 1 0.0155 0.0336 0.0336
Loa Loa (eye worm) p25-alpha family protein 0.0377 0.0881 0.0881
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1734 0.4213 0.4212
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0111 0.0227 0.0227
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0264 0.0605 0.0605
Leishmania major beta tubulin 0.409 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0047 0.0071 0.0071
Schistosoma mansoni thyroid hormone receptor 0.024 0.0545 0.0545
Schistosoma mansoni tubulin subunit delta 0.0946 0.228 0.228
Echinococcus multilocularis mothers against decapentaplegic 5 0.0111 0.0227 0.0227
Trichomonas vaginalis tubulin alpha chain, putative 0.1233 0.2984 0.2984
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0001 0.0001
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0022 0.0022
Brugia malayi Pre-SET motif family protein 0.0215 0.0483 0.0483
Echinococcus multilocularis Tubulin beta 2C chain 0.409 1 1
Entamoeba histolytica histone deacetylase, putative 0.0541 0.1285 0.1283
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0015 0.0014
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0022 0.0022
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0032 0.0035 0.0152
Trypanosoma cruzi PAB1-binding protein , putative 0.0265 0.0606 0.0606
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.0231 0.1011
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0946 0.228 1
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0079 0.0149 0.0656
Echinococcus granulosus tubulin alpha chain 0.2967 0.7242 0.7242
Echinococcus granulosus Tubulin alpha 1 chain 0.2967 0.7242 0.7242
Loa Loa (eye worm) beta-lactamase 0.0037 0.0047 0.0047
Toxoplasma gondii histone deacetylase HDAC5 0.0188 0.0417 0.0417
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0047 0.0047
Echinococcus multilocularis histone deacetylase 6 0.0321 0.0745 0.0745
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0022 0.0022
Loa Loa (eye worm) tubulin alpha-2 chain 0.2967 0.7242 0.7242
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Schistosoma mansoni nAChR subunit 0.0019 0.0001 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0196 0.0196
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0024 0.0015 0.0015
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0024 0.0015 0.0015
Entamoeba histolytica tubulin alpha chain, putative 0.2967 0.7242 0.7241
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.2967 0.7242 0.7241
Echinococcus granulosus tubulin alpha chain 0.2967 0.7242 0.7242
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0033
Schistosoma mansoni isocitrate dehydrogenase 0.0032 0.0035 0.0035
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0048 0.0212
Echinococcus granulosus dihydrofolate reductase 0.0045 0.0066 0.0066
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0048 0.0048
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0132 0.0131
Trichomonas vaginalis tubulin, putative 0.0946 0.228 0.2279
Giardia lamblia DNA topoisomerase II 0.0063 0.0109 0.0107
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0132 0.0131
Brugia malayi Cytochrome P450 family protein 0.0027 0.0022 0.0022
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0001 0.0001
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0001 0.0001
Brugia malayi nuclear receptor RXR 0.0047 0.0071 0.0071
Brugia malayi Tubulin alpha-2 chain 0.2967 0.7242 0.7242
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0047 0.0046
Trypanosoma brucei tubulin delta chain 0.0946 0.228 0.228
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0024 0.0015 0.0015
Leishmania major alpha tubulin 0.2967 0.7242 0.7242
Schistosoma mansoni RAR-like nuclear receptor 0.0111 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.0487 0.1151 0.1151
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0033
Echinococcus multilocularis histone deacetylase 6 0.0297 0.0686 0.0686
Schistosoma mansoni retinoic acid receptor RXR 0.0212 0.0476 0.0476
Echinococcus multilocularis BRCA1 associated protein 0.0024 0.0015 0.0015
Loa Loa (eye worm) tubulin beta-1 chain 0.409 1 1
Brugia malayi histone deacetylase 1 (HD1) 0.0541 0.1285 0.1285
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0001 0.0001
Entamoeba histolytica tartrate dehydrogenase, putative 0.0032 0.0035 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Echinococcus multilocularis Tubulin alpha 1 chain 0.2967 0.7242 0.7242
Schistosoma mansoni dihydrofolate reductase 0.0045 0.0066 0.0066
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0231 0.023
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0015 0.0014
Schistosoma mansoni hypothetical protein 0.0031 0.0032 0.0032
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0111 0.0227 0.0227
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0264 0.0605 0.0605
Echinococcus granulosus Nuclear hormone receptor HR96 0.0047 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.03 0.0692 0.0692
Leishmania major histone deacetylase, putative 0.0541 0.1285 0.1285
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0001 0.0001
Leishmania major DNA polymerase eta, putative 0.0019 0.0002 0.0002
Mycobacterium tuberculosis Probable reductase 0.0111 0.0228 0.1002
Echinococcus granulosus Tubulin beta 2C chain 0.409 1 1
Echinococcus multilocularis thymidylate synthase 0.0111 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0227
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0085 0.0084
Brugia malayi BRCA1-associated protein 2 containing protein 0.0024 0.0015 0.0015
Leishmania major beta tubulin 0.409 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0062 0.0062
Onchocerca volvulus 0.1233 0.2984 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Brugia malayi bZIP transcription factor family protein 0.0086 0.0168 0.0168
Echinococcus granulosus TGF beta signal transducer SmadC 0.0111 0.0227 0.0227
Brugia malayi PAS domain containing protein 0.005 0.0079 0.0079
Brugia malayi beta-lactamase family protein 0.0037 0.0047 0.0047
Trypanosoma cruzi zeta tubulin, putative 0.0946 0.228 0.228
Echinococcus granulosus nuclear receptor nhr 48 0.0047 0.0071 0.0071
Trichomonas vaginalis tubulin epsilon chain, putative 0.2967 0.7242 0.7241
Trichomonas vaginalis brca1-associated protein, putative 0.0024 0.0015 0.0014
Echinococcus granulosus histone deacetylase 7 0.0297 0.0686 0.0686
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0015 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0231 0.023
Trichomonas vaginalis tubulin epsilon chain, putative 0.409 1 1
Schistosoma mansoni alpha tubulin 0.2967 0.7242 0.7242
Loa Loa (eye worm) hypothetical protein 0.0063 0.0111 0.0111
Brugia malayi hypothetical protein 0.032 0.0741 0.0741
Loa Loa (eye worm) hypothetical protein 0.0098 0.0196 0.0196
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0156 0.0338 0.0338
Trypanosoma cruzi tubulin delta chain 0.0946 0.228 0.228
Echinococcus granulosus chromobox protein 1 0.0072 0.0132 0.0132
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.03 0.0692 0.0692
Trichomonas vaginalis tubulin epsilon chain, putative 0.2967 0.7242 0.7241
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0033 0.0033
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0002 0.0002
Onchocerca volvulus 0.0032 0.0033 0.0106
Onchocerca volvulus 0.0111 0.0227 0.0757
Trypanosoma brucei beta tubulin 0.409 1 1
Leishmania major beta tubulin 0.409 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0047 0.0047
Echinococcus multilocularis tubulin alpha 1C chain 0.2967 0.7242 0.7242
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0086
Echinococcus granulosus Tubulin beta 2C chain 0.409 1 1
Trypanosoma cruzi tubulin gamma chain 0.218 0.5309 0.5309
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0259 0.1135
Schistosoma mansoni tubulin subunit beta 0.409 1 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0049 0.0077 0.0077
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0075 0.0067
Chlamydia trachomatis DNA gyrase subunit B 0.0036 0.0043 0.2438
Leishmania major beta tubulin 0.409 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0487 0.1151 0.1151
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0048 0.0048
Echinococcus granulosus histone deacetylase 0.0297 0.0686 0.0686
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0048 0.0048
Schistosoma mansoni cpg binding protein 0.0031 0.0032 0.0032
Echinococcus multilocularis thyroid hormone receptor alpha 0.024 0.0545 0.0545
Leishmania major beta tubulin 0.409 1 1
Brugia malayi tubulin alpha-2 chain 0.2967 0.7242 0.7242
Trypanosoma cruzi epsilon tubulin, putative 0.218 0.5309 0.5309
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0097 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Leishmania major alpha tubulin 0.2967 0.7242 0.7242
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0022 0.0022
Brugia malayi MH1 domain containing protein 0.0111 0.0227 0.0227
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0047 0.0071 0.0071
Brugia malayi Tubulin gamma chain 0.218 0.5309 0.5309
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.015 0.0141
Trypanosoma cruzi histone deacetylase, putative 0.0188 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0032 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.2967 0.7242 0.7242
Giardia lamblia Histone deacetylase 0.0541 0.1285 0.1283
Loa Loa (eye worm) hypothetical protein 0.0109 0.0224 0.0224
Echinococcus multilocularis Tubulin alpha 1 chain 0.2967 0.7242 0.7242
Schistosoma mansoni nAChR subunit 0.0019 0.0001 0.0001
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0007 0.0007
Echinococcus granulosus geminin 0.2835 0.6919 0.6919
Brugia malayi Tubulin beta chain 0.0946 0.228 0.228
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0024 0.0015 0.0015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0111 0.0227 0.0227
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.0231 0.1011
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0029
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0001 0.0001
Trichomonas vaginalis tubulin beta chain, putative 0.2967 0.7242 0.7241
Loa Loa (eye worm) tubulin alpha chain 0.2967 0.7242 0.7242
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0001 0.0001
Brugia malayi Tubulin alpha chain 0.2967 0.7242 0.7242
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0156 0.0338 0.0338
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0051 0.0082 0.0082
Loa Loa (eye worm) Smad1 0.0111 0.0227 0.0227
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0022 0.0097
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0047 0.0205
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0032 0.0035 0.0035
Echinococcus granulosus tubulin alpha 0.218 0.5309 0.5309
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0001 0.0001
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0075 0.033
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0079 0.0149 0.0656
Leishmania major gamma-tubulin 0.218 0.5309 0.5309
Mycobacterium ulcerans epimerase 0.0021 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Trypanosoma cruzi DNA topoisomerase II, putative 0.0059 0.01 0.01
Trichomonas vaginalis tubulin, putative 0.409 1 1
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0015 0.0006
Echinococcus granulosus dna polymerase kappa 0.0019 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0487 0.1151 0.1149
Plasmodium falciparum thioredoxin reductase 0.0049 0.0075 0.0067
Brugia malayi 6-phosphofructokinase 0.0112 0.0231 0.0231
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0264 0.0605 0.0597
Schistosoma mansoni alpha tubulin 0.2967 0.7242 0.7242
Giardia lamblia Beta tubulin 0.409 1 1
Brugia malayi Thioredoxin reductase 0.0049 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.2835 0.6919 0.6919
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0111 0.0227 0.0227
Brugia malayi beta-lactamase family protein 0.0037 0.0047 0.0047
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.02 0.02
Trypanosoma cruzi histone deacetylase 1, putative 0.0541 0.1285 0.1285
Plasmodium falciparum histone deacetylase, putative 0.0297 0.0686 0.0678
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0231 0.0229
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0112 0.023 0.023
Trichomonas vaginalis tubulin gamma chain, putative 0.0946 0.228 0.2279
Echinococcus multilocularis histone deacetylase 7 0.0297 0.0686 0.0686
Echinococcus multilocularis chromobox protein 1 0.0072 0.0132 0.0132
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0022 0.0019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0086 0.0168 0.0168
Schistosoma mansoni smad 0.0049 0.0077 0.0077
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0027 0.0027
Chlamydia trachomatis dihydrofolate reductase 0.0045 0.0066 0.4108
Echinococcus multilocularis muscleblind protein 1 0.03 0.0692 0.0692
Trypanosoma cruzi DNA topoisomerase II, putative 0.0059 0.01 0.01
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0231 0.0231
Schistosoma mansoni tubulin subunit beta 0.409 1 1
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0007 0.0018
Schistosoma mansoni tubulin subunit alpha 0.0946 0.228 0.228
Echinococcus granulosus histone deacetylase 6 0.0297 0.0686 0.0686
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.0553 0.0553
Schistosoma mansoni nAChR subunit 0.0019 0.0001 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0111 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.0067 0.012 0.012
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0002 0.0002
Schistosoma mansoni tubulin subunit gamma 0.218 0.5309 0.5309
Echinococcus granulosus chromobox protein 1 0.0072 0.0132 0.0132
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0077 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0111 0.0227 0.0227
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0097 0.0097
Echinococcus multilocularis musashi 0.0054 0.0089 0.0089
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0048 0.0047
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0053 0.0085 0.0085
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0075 0.0075
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0001 0.0001
Onchocerca volvulus 0.0037 0.0047 0.0152
Trypanosoma brucei unspecified product 0.0019 0.0002 0.0002
Brugia malayi thymidylate synthase 0.0111 0.0227 0.0227
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0111 0.0227 0.0227
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0119 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0111 0.0229 0.0229
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.003 0.0021
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0048 0.0175
Brugia malayi nuclear receptor NHR-88 0.0111 0.0227 0.0227
Toxoplasma gondii LsmAD domain-containing protein 0.0265 0.0606 0.0606
Giardia lamblia Alpha-tubulin 0.2967 0.7242 0.7241
Brugia malayi ecdysteroid receptor 0.0111 0.0227 0.0227
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0111 0.0227 0.0227
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0001 0.0001
Leishmania major alpha tubulin 0.2967 0.7242 0.7242
Echinococcus multilocularis peroxisome assembly protein 26 0.2967 0.7242 0.7242
Echinococcus multilocularis jun protein 0.0086 0.0168 0.0168
Loa Loa (eye worm) histone deacetylase 3 0.0541 0.1285 0.1285
Brugia malayi nuclear hormone receptor 0.0047 0.0071 0.0071
Brugia malayi Tubulin beta chain 0.1233 0.2984 0.2984
Onchocerca volvulus 0.0047 0.0071 0.0235
Trichomonas vaginalis histone deacetylase, putative 0.0541 0.1285 0.1284
Echinococcus granulosus Tubulin alpha 1 chain 0.2967 0.7242 0.7242
Leishmania major alpha tubulin 0.2967 0.7242 0.7242
Loa Loa (eye worm) hypothetical protein 0.0061 0.0106 0.0106
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0062 0.0203
Brugia malayi ecdysone receptor 0.0047 0.0071 0.0071
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Giardia lamblia Alpha-tubulin 0.2967 0.7242 0.7241
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.003 0.0028
Trichomonas vaginalis tubulin alpha chain, putative 0.409 1 1
Brugia malayi Cation transporter family protein 0.0019 0.0001 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.0428 0.0428
Schistosoma mansoni steroid hormone receptor ad4bp 0.0111 0.0227 0.0227
Brugia malayi nuclear hormone receptor 0.0111 0.0227 0.0227
Schistosoma mansoni tubulin subunit beta 0.409 1 1
Brugia malayi Probable DNA topoisomerase II 0.0065 0.0116 0.0116
Echinococcus granulosus single minded 2 0.0037 0.0047 0.0047
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0032 0.0032
Echinococcus granulosus histone deacetylase 6 0.0297 0.0686 0.0686
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0024 0.0015 0.0006
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0001 0.0001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0047 0.0205
Trichomonas vaginalis tubulin alpha chain, putative 0.1233 0.2984 0.2984
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0071 0.0071
Echinococcus multilocularis tubulin alpha 1C chain 0.2967 0.7242 0.7242
Trichomonas vaginalis tubulin alpha chain, putative 0.218 0.5309 0.5308
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0227
Entamoeba histolytica tubulin gamma chain 0.218 0.5309 0.5308
Loa Loa (eye worm) hypothetical protein 0.0063 0.0111 0.0111
Brugia malayi hypothetical protein 0.0068 0.0122 0.0122
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0015 0.0015
Brugia malayi steroid hormone receptor 0.0111 0.0227 0.0227
Onchocerca volvulus 0.0054 0.0089 0.0293
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0133 0.0283 0.0283
Trypanosoma cruzi tubulin delta chain 0.0946 0.228 0.228
Plasmodium vivax histone deacetylase, putative 0.0297 0.0686 0.0678
Echinococcus multilocularis dna polymerase eta 0.0019 0.0002 0.0002
Brugia malayi Steroid receptor seven-up type 2 0.0111 0.0227 0.0227
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0022 0.0022
Loa Loa (eye worm) nuclear factor I 0.0061 0.0106 0.0106
Echinococcus granulosus tubulin subunit beta 0.409 1 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0264 0.0605 0.0605
Brugia malayi nuclear receptor NHR-88 0.0047 0.0071 0.0071
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0024 0.0015 0.0012
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0047 0.0071 0.0071
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0001 0.0001
Leishmania major histone deacetylase, putative 0.0541 0.1285 0.1285
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0001 0.0001
Echinococcus multilocularis tumor protein p63 0.0678 0.1622 0.1622
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0295 0.0679 0.0679
Brugia malayi beta-lactamase 0.0037 0.0047 0.0047
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0172 0.0172
Echinococcus granulosus flap endonuclease 1 0.0027 0.0022 0.0022
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0149 0.0321 0.0321
Loa Loa (eye worm) thymidylate synthase 0.0111 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0063 0.0111 0.0111
Leishmania major beta tubulin 0.409 1 1
Chlamydia trachomatis endonuclease IV 0.0079 0.0149 1
Trypanosoma brucei zeta tubulin 0.0946 0.228 0.228
Echinococcus multilocularis tubulin alpha chain 0.2967 0.7242 0.7242
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0227
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0022 0.0021
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0111 0.0227 0.0227
Schistosoma mansoni single-minded 0.005 0.0079 0.0079
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0063 0.0111 0.0111
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0045 0.0066 0.0292
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0002 0.0009
Schistosoma mansoni histone deacetylase 4 5 0.0297 0.0686 0.0686
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0032 0.0035 0.0114
Loa Loa (eye worm) pax transcription factor protein 2 0.0775 0.186 0.186
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0032 0.0035 0.0152
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0047 0.0046
Schistosoma mansoni cpg binding protein 0.0031 0.0032 0.0032
Onchocerca volvulus 0.0245 0.0556 0.186
Plasmodium vivax SET domain protein, putative 0.0031 0.0033 0.0024
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0212 0.0476 0.0476
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0015 0.0014
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0048 0.0048
Echinococcus granulosus neuropeptide receptor A26 0.048 0.1135 0.1135
Brugia malayi hypothetical protein 0.0063 0.0111 0.0111
Trichomonas vaginalis histone deacetylase, putative 0.0541 0.1285 0.1284
Brugia malayi hypothetical protein 0.0053 0.0085 0.0085
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0047 0.0205
Trypanosoma brucei histone deacetylase, putative 0.0297 0.0686 0.0686
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0111 0.0227 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0033 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0265 0.0606 0.0606
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0029
Giardia lamblia Beta tubulin 0.409 1 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0049 0.0077 0.0254
Mycobacterium tuberculosis Conserved protein 0.0037 0.0047 0.0205
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0111 0.0227 0.0227
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0065 0.0116 0.0116
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0172 0.0171
Echinococcus multilocularis tubulin alpha 0.218 0.5309 0.5309
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0097 0.0097
Brugia malayi follicle stimulating hormone receptor 0.0243 0.0553 0.0553
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0156 0.0338 0.0338
Echinococcus granulosus CREB binding protein 0.0112 0.023 0.023
Echinococcus granulosus cpg binding protein 0.0031 0.0032 0.0032
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0024 0.0015 0.0015
Echinococcus granulosus mothers against decapentaplegic 6 0.0049 0.0077 0.0077
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0001 0.0001
Leishmania major beta tubulin 0.409 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0047 0.0205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0033 0.0033
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.0274 0.0274
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.0428 0.0428
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0015 0.0014
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0001 0.0001
Onchocerca volvulus 0.0047 0.0071 0.0235
Schistosoma mansoni cpg binding protein 0.003 0.0028 0.0028
Echinococcus multilocularis Tubulin beta 2C chain 0.409 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0002 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0071 0.0071
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.0231 0.1011
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0079 0.0149 0.0149
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.0428 0.0428
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Echinococcus granulosus thymidylate synthase 0.0111 0.0227 0.0227
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0032 0.0035 0.0035
Brugia malayi Cytochrome P450 family protein 0.0027 0.0022 0.0022
Schistosoma mansoni nAChR subunit 0.0019 0.0001 0.0001
Onchocerca volvulus 0.0111 0.0227 0.0758
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0264 0.0605 0.2653
Echinococcus multilocularis tubulin alpha 3 chain 0.2967 0.7242 0.7242
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Echinococcus multilocularis Tubulin alpha 1 chain 0.2967 0.7242 0.7242
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0022 0.0022
Toxoplasma gondii DNA topoisomerase 2, putative 0.0065 0.0116 0.0116
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0259 0.1135
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0001 0.0001
Loa Loa (eye worm) tubulin beta-4 chain 0.409 1 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0227
Loa Loa (eye worm) tubulin alpha chain 0.2967 0.7242 0.7242
Loa Loa (eye worm) glutathione reductase 0.0049 0.0075 0.0075
Echinococcus multilocularis mothers against decapentaplegic 6 0.0049 0.0077 0.0077
Onchocerca volvulus 0.0068 0.0122 0.0406
Loa Loa (eye worm) hypothetical protein 0.202 0.4917 0.4917
Trypanosoma brucei zeta tubulin, putative 0.0946 0.228 0.228
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0172 0.0163
Brugia malayi Heterochromatin protein 1 0.0072 0.0132 0.0132
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0059 0.01 0.01
Echinococcus multilocularis Tubulin beta 2C chain 0.409 1 1
Trichomonas vaginalis set domain proteins, putative 0.0245 0.0556 0.0555
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0071 0.0071
Trichomonas vaginalis tubulin, putative 0.1233 0.2984 0.2984
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0022 0.0022
Echinococcus granulosus CREB binding protein 0.0072 0.0131 0.0131
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.0428 0.0428
Echinococcus granulosus tubulin alpha 1C chain 0.2967 0.7242 0.7242
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0024 0.0015 0.0006
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0111 0.0227 0.0227
Brugia malayi acetyltransferase, GNAT family protein 0.0295 0.0679 0.0679
Trichomonas vaginalis DNA topoisomerase II, putative 0.0065 0.0116 0.0116
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0048 0.0212
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0264 0.0605 0.0605
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Brugia malayi hypothetical protein 0.0063 0.0111 0.0111
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0063 0.0111 0.0111
Brugia malayi photoreceptor-specific nuclear receptor 0.0111 0.0227 0.0227
Leishmania major beta tubulin 0.409 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0007 0.0029
Brugia malayi mothers against decapentaplegic homolog 3 0.0049 0.0077 0.0077
Leishmania major beta tubulin 0.409 1 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0172 0.0171
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0111 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0025 0.0017 0.0017
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0022 0.0013
Loa Loa (eye worm) hypothetical protein 0.1734 0.4213 0.4213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0032 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.0428 0.0428
Echinococcus multilocularis Smad4 0.0111 0.0227 0.0227
Trypanosoma brucei DNA topoisomerase ii 0.0051 0.0082 0.0082
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0002 0.0002
Plasmodium falciparum DNA topoisomerase 2 0.0065 0.0116 0.0108
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0079 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.007 0.0128 0.0128
Onchocerca volvulus 0.0038 0.0048 0.0157
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0002 0.0002
Trypanosoma cruzi histone deacetylase 1, putative 0.0541 0.1285 0.1285
Schistosoma mansoni alpha tubulin 0.2967 0.7242 0.7242
Schistosoma mansoni nuclear receptor 0.0047 0.0071 0.0071
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0015 0.0015
Leishmania major alpha tubulin 0.2967 0.7242 0.7242
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0015 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0047 0.0047
Echinococcus granulosus tubulin alpha chain 0.2967 0.7242 0.7242
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.0537 0.2357
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0028 0.0028
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.002 0.002
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0001 0.0001
Plasmodium vivax histone deacetylase, putative 0.0188 0.0417 0.0409
Brugia malayi MH2 domain containing protein 0.1624 0.3943 0.3943
Giardia lamblia Gamma tubulin 0.218 0.5309 0.5308
Trichomonas vaginalis tubulin gamma chain, putative 0.218 0.5309 0.5308
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0111 0.0227 0.0227
Treponema pallidum cell division protein FtsZ 0.0946 0.228 1
Trypanosoma brucei epsilon tubulin 0.218 0.5309 0.5309
Loa Loa (eye worm) hypothetical protein 0.0188 0.0417 0.0417
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0541 0.1285 0.1284
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0487 0.1151 0.1151
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0079 0.0149 0.0141
Echinococcus granulosus histone acetyltransferase KAT2B 0.0285 0.0655 0.0655
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0024 0.0015 0.0015
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0024 0.0015 0.0015
Loa Loa (eye worm) tubulin alpha-3 chain 0.1734 0.4213 0.4213
Toxoplasma gondii beta tubulin 0.409 1 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0295 0.0679 0.0679
Trichomonas vaginalis tubulin beta chain, putative 0.2967 0.7242 0.7241
Loa Loa (eye worm) hypothetical protein 0.0541 0.1285 0.1285
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Plasmodium falciparum tubulin delta chain, putative 0.0946 0.228 0.2273
Toxoplasma gondii isocitrate dehydrogenase 0.0264 0.0605 0.0605
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0033 0.0033
Brugia malayi Cation transporter family protein 0.0019 0.0001 0.0001
Schistosoma mansoni histone deacetylase 0.0541 0.1285 0.1285
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0065 0.0116 0.0116
Schistosoma mansoni histone deacetylase 0.0541 0.1285 0.1285
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0231 0.0231
Brugia malayi Tubulin alpha chain 0.0946 0.228 0.228
Schistosoma mansoni tubulin subunit alpha 0.2967 0.7242 0.7242
Schistosoma mansoni nAChR subunit 0.0019 0.0001 0.0001
Echinococcus multilocularis tubulin alpha chain 0.2967 0.7242 0.7242
Echinococcus multilocularis isocitrate dehydrogenase 0.0264 0.0605 0.0605
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0047 0.0205
Entamoeba histolytica tubulin family protein 0.409 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Brugia malayi p25-alpha family protein 0.0377 0.0881 0.0881
Schistosoma mansoni flap endonuclease-1 0.0024 0.0015 0.0015
Toxoplasma gondii exonuclease III APE 0.0038 0.0048 0.0048
Loa Loa (eye worm) acetyltransferase 0.0295 0.0679 0.0679
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.0231 0.0231
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0111 0.0227 0.0227
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0024 0.0015 0.0015
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.003 0.1515
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0089 0.0089
Trichomonas vaginalis tubulin gamma chain, putative 0.409 1 1
Leishmania major hypothetical protein, conserved 0.0265 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.032 0.0741 0.0741
Brugia malayi nuclear hormone receptor family member nhr-6 0.0047 0.0071 0.0071
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0047 0.0071 0.0071
Entamoeba histolytica hypothetical protein 0.0487 0.1151 0.1149
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.002
Onchocerca volvulus 0.0099 0.02 0.0664
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0032
Schistosoma mansoni ap endonuclease 0.0038 0.0048 0.0048
Brugia malayi Cell division protein ftsZ 0.0946 0.228 0.228
Onchocerca volvulus 0.003 0.0028 0.009
Echinococcus multilocularis Tubulin beta 2C chain 0.409 1 1
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0032 0.0035 0.0035
Plasmodium vivax tubulin alpha chain, putative 0.2967 0.7242 0.7239
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0001 0.0001
Mycobacterium ulcerans thymidylate synthase 0.0111 0.0227 0.0997
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.002 0.002
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0111 0.0227 0.0227
Entamoeba histolytica tubulin family protein 0.409 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0002 0.0002
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0156 0.0338 0.033
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.0231 0.0231
Echinococcus multilocularis lamin dm0 0.0054 0.0089 0.0089
Trypanosoma brucei histone deacetylase 1 0.0541 0.1285 0.1285
Echinococcus multilocularis Tubulin beta 2C chain 0.409 1 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.012 0.012
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.015 0.0148
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0033 0.0033
Plasmodium vivax ataxin-2 like protein, putative 0.0265 0.0606 0.0598
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0024 0.0015 0.0012
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0051 0.0082 0.0082
Echinococcus granulosus tubulin beta 1 chain 0.409 1 1
Schistosoma mansoni Smad4 0.0111 0.0227 0.0227
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0028 0.0028
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0047 0.0205
Loa Loa (eye worm) histone deacetylase 1 0.0541 0.1285 0.1285
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0111 0.0227 0.0227
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Mycobacterium leprae Probable lipase LipE 0.0037 0.0047 0.0205
Mycobacterium ulcerans lipase LipD 0.0037 0.0047 0.0205
Brugia malayi alpha-tubulin 0.2967 0.7242 0.7242
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0047 0.0071 0.0235
Brugia malayi Pax transcription factor protein 2 0.0775 0.186 0.186
Loa Loa (eye worm) tubulin alpha 2 0.0787 0.1889 0.1889
Trypanosoma cruzi histone deacetylase, putative 0.0188 0.0417 0.0417
Brugia malayi conserved hypotetical protein 0.0047 0.0071 0.0071
Echinococcus multilocularis nAChR subunit 0.0019 0.0001 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0001 0.0001
Echinococcus granulosus tubulin alpha 1C chain 0.2967 0.7242 0.7242
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0111 0.0227 0.0227
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0156 0.0338 0.033
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0075 0.0075
Onchocerca volvulus TPPP family protein homolog 0.0377 0.0881 0.2949
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0001 0.0001
Loa Loa (eye worm) steroid hormone receptor 0.0111 0.0227 0.0227
Trypanosoma brucei trypanothione reductase 0.0049 0.0075 0.0075
Echinococcus granulosus Smad4 0.0111 0.0227 0.0227
Echinococcus granulosus beta tubulin 0.409 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0111 0.0227 0.0227
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0264 0.0605 0.0605
Trypanosoma brucei beta tubulin 0.409 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0487 0.1151 0.1151
Loa Loa (eye worm) hypothetical protein 0.0049 0.0076 0.0076
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0101 0.0101
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0032 0.0035 0.0035
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0001 0.0001
Trichomonas vaginalis histone deacetylase, putative 0.0541 0.1285 0.1284
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0111 0.0227 0.0227
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0111 0.0227 0.0997
Toxoplasma gondii endonuclease IV APN 0.0079 0.0149 0.0149
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0027 0.0027
Leishmania major zeta tubulin, putative 0.0946 0.228 0.228
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0089 0.0089
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0228 0.1002
Brugia malayi MH1 domain containing protein 0.0061 0.0106 0.0106
Toxoplasma gondii ABC1 family protein 0.0037 0.0047 0.0047
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0024 0.0015 0.0015
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0086 0.0168 0.0168
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0111 0.0227 0.0757
Loa Loa (eye worm) tubulin alpha 2 0.202 0.4917 0.4917
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0047 0.0205
Leishmania major histone deacetylase, putative 0.0297 0.0686 0.0686
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0001 0.0001
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0015 0.0015
Toxoplasma gondii beta-1 tubulin, putative 0.409 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0111 0.0227 0.0227
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0015 0.0015
Leishmania major cytochrome p450-like protein 0.0027 0.0022 0.0022
Trichomonas vaginalis histone deacetylase, putative 0.0541 0.1285 0.1284
Brugia malayi dihydrofolate reductase family protein 0.0045 0.0066 0.0066
Echinococcus granulosus muscleblind protein 0.03 0.0692 0.0692
Echinococcus multilocularis tubulin delta chain 0.0946 0.228 0.228
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.202 0.4917 0.4917
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0228 0.1002
Schistosoma mansoni lamin 0.0054 0.0089 0.0089
Echinococcus multilocularis histone deacetylase 8 0.0188 0.0417 0.0417
Entamoeba histolytica hypothetical protein 0.0487 0.1151 0.1149
Echinococcus granulosus Tubulin alpha 1 chain 0.2967 0.7242 0.7242
Trypanosoma brucei histone deacetylase 2 0.0188 0.0417 0.0417
Plasmodium vivax tubulin alpha chain, putative 0.2967 0.7242 0.7239
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0047 0.0046
Trypanosoma brucei PAB1-binding protein , putative 0.0265 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Plasmodium vivax delta tubulin, putative 0.0946 0.228 0.2273
Schistosoma mansoni chromobox protein 0.0072 0.0132 0.0132
Trichomonas vaginalis BRCA1-associated protein, putative 0.0024 0.0015 0.0014
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0062 0.0061
Toxoplasma gondii 6-phosphofructokinase 0.003 0.003 0.003
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1233 0.2984 0.2984
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0024 0.0015 0.0012
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0111 0.0227 0.0227
Schistosoma mansoni unc-13 (munc13) 0.0032 0.0035 0.0035
Loa Loa (eye worm) histone deacetylase 11 0.0188 0.0417 0.0417
Schistosoma mansoni Smad4 0.0049 0.0077 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0053
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0007 0.0029
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0002 0.0001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1628 0.3954 0.3954
Schistosoma mansoni Smad4 0.0049 0.0077 0.0077
Trypanosoma brucei alpha tubulin 0.2967 0.7242 0.7242
Trypanosoma brucei alpha tubulin, putative 0.1233 0.2984 0.2984
Leishmania major beta tubulin 0.409 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0022 0.0022
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0032 0.0035 0.0035
Echinococcus multilocularis GPCR, family 2 0.0031 0.0032 0.0032
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0231 0.0229
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0541 0.1285 0.1284
Brugia malayi phosphofructokinase 0.0112 0.0231 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0111 0.0227 0.0227
Brugia malayi hypothetical protein 0.0047 0.0071 0.0071
Trichomonas vaginalis histone deacetylase, putative 0.0541 0.1285 0.1284
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0101 0.0101
Giardia lamblia Delta tubulin 0.0946 0.228 0.2278
Schistosoma mansoni intermediate filament proteins 0.0054 0.0089 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0111 0.0227 0.0227
Brugia malayi Histone deacetylase family protein 0.0297 0.0686 0.0686
Schistosoma mansoni jun-related protein 0.007 0.0128 0.0128
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0231 0.0231
Leishmania major alpha tubulin 0.2967 0.7242 0.7242
Trichomonas vaginalis tubulin beta chain, putative 0.409 1 1
Brugia malayi jmjC domain containing protein 0.0058 0.0097 0.0097
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0024 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0027
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0032 0.0035 0.0035
Trichomonas vaginalis tubulin beta chain, putative 0.1233 0.2984 0.2984
Plasmodium vivax tubulin gamma chain, putative 0.218 0.5309 0.5305
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0002 0.0001
Brugia malayi Cation transporter family protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) tubulin beta chain 0.409 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.1233 0.2984 0.2984
Loa Loa (eye worm) tubulin beta-2A chain 0.409 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0111 0.0227 0.0757
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0022 0.0009 0.0038
Loa Loa (eye worm) hypothetical protein 0.0084 0.0162 0.0162
Brugia malayi chromobox protein homolog 3 0.004 0.0054 0.0054
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0031 0.0032 0.0032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0047 0.0047
Schistosoma mansoni histone deacetylase hda2 0.0188 0.0417 0.0417
Trypanosoma brucei beta tubulin 0.409 1 1
Onchocerca volvulus 0.0054 0.0089 0.0293
Leishmania major beta tubulin 0.409 1 1
Leishmania major alpha tubulin 0.2967 0.7242 0.7242
Plasmodium vivax tubulin beta chain, putative 0.409 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0048 0.0046
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.0274 0.0274
Brugia malayi beta-tubulin, identical 0.409 1 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0033 0.0033
Onchocerca volvulus Histone deacetylase 10 homolog 0.0188 0.0417 0.1394
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0001 0.0001
Echinococcus granulosus peroxisome assembly protein 26 0.2967 0.7242 0.7242
Schistosoma mansoni tubulin subunit epsilon 0.218 0.5309 0.5309
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0111 0.0227 0.0227
Leishmania major mitochondrial DNA topoisomerase II 0.0051 0.0082 0.0082
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0032 0.0035 0.0035
Brugia malayi hypothetical protein 0.0168 0.0368 0.0368
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0048 0.0047
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0001 0.0001
Echinococcus multilocularis histone deacetylase 3 0.0541 0.1285 0.1285
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Schistosoma mansoni DNA topoisomerase II 0.0065 0.0116 0.0116
Echinococcus granulosus tumor protein p63 0.0678 0.1622 0.1622
Leishmania major isocitrate dehydrogenase, putative 0.0032 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0264 0.0605 0.0605
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0047 0.0072 0.0238
Echinococcus multilocularis dihydrofolate reductase 0.0045 0.0066 0.0066
Trypanosoma brucei beta tubulin 0.218 0.5309 0.5309
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0111 0.0227 0.0227
Trypanosoma cruzi histone deacetylase, putative 0.0297 0.0686 0.0686
Trypanosoma brucei epsilon tubulin 0.218 0.5309 0.5309
Trypanosoma cruzi histone deacetylase, putative 0.0297 0.0686 0.0686
Echinococcus multilocularis transcription factor eb 0.0111 0.0229 0.0229
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.003 0.1515
Echinococcus granulosus tubulin delta chain 0.0946 0.228 0.228
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0065 0.0116 0.0116
Plasmodium vivax tubulin epsilon chain, putative 0.218 0.5309 0.5305
Plasmodium falciparum alpha tubulin 2 0.2967 0.7242 0.7239
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0048 0.004
Toxoplasma gondii thioredoxin reductase 0.0049 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.2835 0.6919 0.6919
Loa Loa (eye worm) transcription factor SMAD2 0.1624 0.3943 0.3943
Brugia malayi TAZ zinc finger family protein 0.0112 0.023 0.023
Brugia malayi Histone deacetylase family protein 0.0297 0.0686 0.0686
Toxoplasma gondii isocitrate dehydrogenase 0.0264 0.0605 0.0605
Schistosoma mansoni tubulin subunit alpha 0.2967 0.7242 0.7242
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0264 0.0605 0.0605
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0024 0.0015 0.0044
Leishmania major beta tubulin 0.409 1 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0002 0.0002
Trypanosoma brucei beta tubulin 0.409 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0168 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0044 0.0064 0.0064
Trichomonas vaginalis tubulin beta chain, putative 0.2967 0.7242 0.7241
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0047 0.0071 0.0071
Brugia malayi hypothetical protein 0.0487 0.1151 0.1151
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0111 0.0227 0.0997
Trypanosoma brucei alpha tubulin 0.2967 0.7242 0.7242
Echinococcus multilocularis tubulin gamma 1 chain 0.218 0.5309 0.5309
Brugia malayi jmjC domain containing protein 0.0059 0.0101 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0111 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0111 0.0227 0.0227
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0001 0.0001
Echinococcus granulosus tubulin alpha chain 0.2967 0.7242 0.7242
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0024 0.0015 0.0015
Leishmania major beta tubulin 0.409 1 1
Brugia malayi Probable isocitrate dehydrogenase 0.0032 0.0035 0.0035
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0024 0.0015 0.0015
Loa Loa (eye worm) BEN-1 protein 0.409 1 1
Schistosoma mansoni smad1 5 8 and 0.0111 0.0227 0.0227
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0483 0.0483
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0047 0.0072 0.0238
Loa Loa (eye worm) alpha-tubulin isotype 2 0.202 0.4917 0.4917
Echinococcus multilocularis tubulin epsilon chain 0.218 0.5309 0.5309
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0027
Brugia malayi tailless protein 0.0047 0.0071 0.0071
Toxoplasma gondii alpha tubulin TUBA1 0.2967 0.7242 0.7242
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0048 0.0046
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0001 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0032 0.0035 0.0034
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0227
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0172 0.0172
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0063 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0047 0.0071 0.0071
Trichomonas vaginalis tubulin epsilon chain, putative 0.409 1 1
Schistosoma mansoni chromobox protein 0.0072 0.0132 0.0132
Trypanosoma cruzi histone deacetylase, putative 0.0297 0.0686 0.0686
Brugia malayi Nuclear hormone receptor-like 1 0.0063 0.0111 0.0111
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0111 0.0227 0.0227
Leishmania major epsilon tubulin, putative 0.218 0.5309 0.5309
Echinococcus multilocularis tubulin alpha chain 0.2967 0.7242 0.7242
Plasmodium vivax histone deacetylase 2, putative 0.0297 0.0686 0.0678
Echinococcus granulosus histone deacetylase 6 0.0321 0.0745 0.0745
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0001 0.0001
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0002 0.0002
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0024 0.0015 0.0012
Brugia malayi orphan nuclear receptor NR2E1 0.0047 0.0071 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0231 0.023
Loa Loa (eye worm) tubulin beta chain 0.0946 0.228 0.228
Toxoplasma gondii histone deacetylase HDAC2 0.0541 0.1285 0.1285
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0111 0.0227 0.0227
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0172 0.0172
Schistosoma mansoni thyroid hormone receptor 0.024 0.0545 0.0545
Brugia malayi MH1 domain containing protein 0.0061 0.0106 0.0106
Leishmania major delta tubulin, putative 0.0946 0.228 0.228
Trypanosoma cruzi alpha tubulin, putative 0.2967 0.7242 0.7242
Trypanosoma brucei histone deacetylase 3 0.0297 0.0686 0.0686
Plasmodium falciparum tubulin epsilon chain, putative 0.218 0.5309 0.5305
Schistosoma mansoni hypothetical protein 0.0053 0.0086 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0071 0.0071
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0001 0.0001
Echinococcus granulosus neuropeptide s receptor 0.048 0.1135 0.1135
Schistosoma mansoni hypothetical protein 0.0031 0.0032 0.0032
Mycobacterium ulcerans hypothetical protein 0.0037 0.0047 0.0205
Echinococcus multilocularis geminin 0.2835 0.6919 0.6919
Toxoplasma gondii alpha-tubulin I, putative 0.2967 0.7242 0.7242
Brugia malayi MH2 domain containing protein 0.0111 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Echinococcus granulosus tubulin gamma 1 chain 0.218 0.5309 0.5309
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0031 0.0032 0.0032
Mycobacterium ulcerans endonuclease IV 0.0079 0.0149 0.0656
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0001 0.0001
Plasmodium falciparum tubulin beta chain 0.409 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Loa Loa (eye worm) TOPoisomerase family member 0.0065 0.0116 0.0116
Leishmania major alpha tubulin 0.2967 0.7242 0.7242
Leishmania major beta tubulin 0.409 1 1
Brugia malayi Nuclear hormone receptor E75 0.0047 0.0071 0.0071
Leishmania major DNA topoisomerase ii 0.0059 0.01 0.01
Schistosoma mansoni smad1 5 8 and 0.0111 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0054
Echinococcus granulosus Tubulin beta 2C chain 0.409 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0048 0.0048
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0001 0.0001
Brugia malayi glutathione reductase 0.0049 0.0075 0.0075
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.0231 0.0231
Trypanosoma brucei tubulin gamma chain 0.218 0.5309 0.5309
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0946 0.228 0.2279
Schistosoma mansoni coup transcription factor 0.0111 0.0227 0.0227
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0111 0.0227 0.0227
Echinococcus granulosus tubulin alpha 3 chain 0.2967 0.7242 0.7242
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0001 0.0001
Echinococcus multilocularis histone deacetylase 0.0297 0.0686 0.0686
Onchocerca volvulus Bile acid receptor homolog 0.0111 0.0227 0.0757
Loa Loa (eye worm) hypothetical protein 0.0049 0.0077 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0026 0.0025
Echinococcus granulosus Tubulin beta 2C chain 0.409 1 1
Schistosoma mansoni ap endonuclease 0.0038 0.0048 0.0048
Echinococcus granulosus beta tubulin 0.409 1 1
Giardia lamblia Epsilon tubulin 0.0946 0.228 0.2278
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0022 0.0022
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.003 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0047 0.0047
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0015 0.0015
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.003 0.0028
Schistosoma mansoni nuclear receptor 0.0047 0.0071 0.0071
Brugia malayi Muscleblind-like protein 0.03 0.0692 0.0692
Loa Loa (eye worm) MH2 domain-containing protein 0.1624 0.3943 0.3943
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Leishmania major histone deacetylase, putative 0.0297 0.0686 0.0686
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) DR-78 0.0047 0.0071 0.0071
Toxoplasma gondii histone deacetylase HDAC4 0.0188 0.0417 0.0417
Trichomonas vaginalis tubulin, putative 0.1233 0.2984 0.2984
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0259 0.1135
Schistosoma mansoni nAChR subunit 0.0019 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0024 0.0015 0.0015
Onchocerca volvulus 0.0037 0.0047 0.0152
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0264 0.0605 0.0605
Loa Loa (eye worm) nuclear hormone receptor 0.0047 0.0071 0.0071
Echinococcus multilocularis CREB binding protein 0.0079 0.0149 0.0149
Schistosoma mansoni nuclear hormone receptor 0.0111 0.0227 0.0227
Echinococcus granulosus FTZ F1 alpha 0.0111 0.0227 0.0227
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0089 0.0089
Giardia lamblia Hypothetical protein 0.0024 0.0015 0.0012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0054 0.0178
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0047 0.0071 0.0235
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0024 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0007
Echinococcus multilocularis tubulin subunit TubB 0.2967 0.7242 0.7242
Mycobacterium tuberculosis Cell division protein FtsZ 0.0946 0.228 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0111 0.0227 0.0227
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0259 0.1135
Giardia lamblia Beta tubulin 0.409 1 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.003 0.003
Schistosoma mansoni histone deacetylase 4 5 0.0297 0.0686 0.0686
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.012 0.012
Loa Loa (eye worm) alpha-tubulin 0.2967 0.7242 0.7242
Schistosoma mansoni brca1-associated protein (brap2) 0.0024 0.0015 0.0015
Trichomonas vaginalis histone deacetylase, putative 0.0541 0.1285 0.1284
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0033 0.0033
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0024 0.0015 0.0015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0228 0.1002
Mycobacterium ulcerans cell division protein FtsZ 0.0946 0.228 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0017 0.0017
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0002 0.0009
Brugia malayi Dihydrofolate reductase 0.0045 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0053
Loa Loa (eye worm) nuclear receptor NHR-67 0.0047 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0015 0.0014
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0002 0.0002
Trypanosoma cruzi epsilon tubulin, putative 0.218 0.5309 0.5309
Loa Loa (eye worm) hypoxia-induced factor 1 0.0155 0.0336 0.0336
Echinococcus granulosus tubulin epsilon chain 0.218 0.5309 0.5309
Echinococcus multilocularis tubulin, beta 4A class IVa 0.409 1 1
Loa Loa (eye worm) tubulin alpha 2 0.202 0.4917 0.4917
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0047 0.0205
Leishmania major hypothetical protein, conserved 0.0024 0.0015 0.0015
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0002 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0111 0.0227 0.0227
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0101 0.0101
Loa Loa (eye worm) tubulin gamma chain 0.218 0.5309 0.5309
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.218 0.5309 0.5309
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0428 0.0428
Onchocerca volvulus 0.0043 0.0062 0.0202
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0228 0.1002
Brugia malayi hypothetical protein 0.0171 0.0376 0.0376
Schistosoma mansoni tubulin subunit beta 0.409 1 1
Leishmania major alpha tubulin 0.2967 0.7242 0.7242
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0228 0.1002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0196 0.0196
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.003 0.0021
Schistosoma mansoni DNA polymerase eta 0.0019 0.0002 0.0002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0048 0.0175
Loa Loa (eye worm) BEN-1 protein 0.409 1 1
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0044 0.0064 0.0064
Leishmania major alpha tubulin 0.2967 0.7242 0.7242
Schistosoma mansoni tubulin subunit beta 0.409 1 1
Trypanosoma brucei histone deacetylase 4 0.0297 0.0686 0.0686
Echinococcus granulosus smad 0.0111 0.0227 0.0227
Trichomonas vaginalis tubulin beta chain, putative 0.2967 0.7242 0.7241
Echinococcus granulosus tubulin alpha chain 0.2967 0.7242 0.7242
Echinococcus granulosus tubulin beta 4A class IVa 0.409 1 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0001 0.0001
Echinococcus granulosus histone deacetylase 1 0.0541 0.1285 0.1285
Echinococcus multilocularis smad 0.0111 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Echinococcus granulosus tubulin subunit TubB 0.2967 0.7242 0.7242
Schistosoma mansoni CREB-binding protein 2 0.0112 0.023 0.023
Echinococcus granulosus transcription factor eb 0.0111 0.0229 0.0229
Toxoplasma gondii histone deacetylase HDAC3 0.0541 0.1285 0.1285
Plasmodium falciparum ataxin-2 like protein, putative 0.0265 0.0606 0.0598
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0071
Trypanosoma cruzi zeta tubulin, putative 0.0946 0.228 0.228
Echinococcus multilocularis cpg binding protein 0.0031 0.0032 0.0032
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0048 0.004
Leishmania major DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0045 0.0066 0.0292
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0118 0.0118
Schistosoma mansoni smad 0.0111 0.0227 0.0227
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0079 0.0149 0.0141
Loa Loa (eye worm) dihydrofolate reductase 0.0045 0.0066 0.0066
Echinococcus granulosus jun protein 0.0086 0.0168 0.0168
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0047 0.0047
Echinococcus multilocularis ecdysone induced protein 78C 0.0111 0.0227 0.0227
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0047 0.0205
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0231 0.0231
Brugia malayi nuclear receptor NHR-67 0.0047 0.0071 0.0071
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0054 0.0089 0.0089
Loa Loa (eye worm) phosphofructokinase 0.0112 0.0231 0.0231
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0015 0.0015
Brugia malayi hypothetical protein 0.0047 0.0071 0.0071
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0001 0.0001
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0946 0.228 0.228
Echinococcus multilocularis tubulin subunit beta 0.409 1 1
Echinococcus multilocularis tubulin beta 1 chain 0.409 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0047 0.0071 0.0071
Toxoplasma gondii histone deacetylase HDAC1 0.0297 0.0686 0.0686
Schistosoma mansoni hypothetical protein 0.013 0.0274 0.0274
Echinococcus multilocularis chromobox protein 1 0.0072 0.0132 0.0132
Brugia malayi MH1 domain containing protein 0.0111 0.0227 0.0227
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0119 0.0247 0.0247
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0024 0.0015 0.0015
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0946 0.228 0.228
Loa Loa (eye worm) hypothetical protein 0.0265 0.0606 0.0606
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Brugia malayi isocitrate dehydrogenase 0.0264 0.0605 0.0605
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0111 0.0227 0.0227
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0032 0.0035 0.0035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0111 0.0227 0.0227
Plasmodium falciparum flap endonuclease 1 0.0027 0.0022 0.0013
Schistosoma mansoni lamin 0.0054 0.0089 0.0089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0428 0.0428
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0047 0.0071 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Echinococcus granulosus nAChR subunit 0.0019 0.0001 0.0001

Activities

Activity type Activity value Assay description Source Reference
Average weight (functional) = 25.6 Average weight of the mouse after treating with 30 mg/kg dose for 1 day. ChEMBL. 6620303
Average weight (functional) = 25.8 Average weight of the mouse after treating with 15 mg/kg dose for 1 day. ChEMBL. 6620303
ILS (functional) = 33 % In vivo anti tumor activity against L1210 leukemia in 5 mice measured as Increased life span at 15 mg/kg. ChEMBL. 6620303
ILS (functional) = 33 % In vivo anti tumor activity against L1210 leukemia in 5 mice measured as Increased life span at 15 mg/kg. ChEMBL. 6620303
ILS (functional) = 100 % In vivo antitumor activity against L1210 leukemia in 5 mice measured as Increased life span at 30 mg/kg. ChEMBL. 6620303
ILS (functional) = 100 % In vivo antitumor activity against L1210 leukemia in 5 mice measured as Increased life span at 30 mg/kg. ChEMBL. 6620303
Range (functional) = 14 In vivo antitumor activity against L1210 leukemia in 5 mice measured as median survival range at 15 mg/kg; Value ranges from (12-14). ChEMBL. 6620303
Range (functional) = 22 In vivo antitumor activity against L1210 leukemia in 5 mice measured as median survival range at 30 mg/kg; Value ranges from(17-22). ChEMBL. 6620303
T/C (functional) = 9 In vivo antitumor activity against L1210 leukemia in 12 mice measured as T/C values; T/C = 12/9 ChEMBL. 6620303
T/C (functional) = 9 In vivo antitumor activity against L1210 leukemia in 18 mice measured as T/C values; T/C = 18/9 ChEMBL. 6620303
Weight change (functional) = 0.4 Average weight change in mouse after treating with 15 mg/kg dose for 7 days. ChEMBL. 6620303
Weight change (functional) = 1.6 Average weight of the mouse after treating with 30 mg/kg dose for 7 day. ChEMBL. 6620303

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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