Detailed information for compound 46809

Basic information

Technical information
  • TDR Targets ID: 46809
  • Name: N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydr oxy-3,5-diiodobenzamide
  • MW: 626.01 | Formula: C19H11Cl2I2NO3
  • H donors: 2 H acceptors: 2 LogP: 7.04 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)Oc1ccc(cc1Cl)NC(=O)c1cc(I)cc(c1O)I
  • InChi: 1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26)
  • InChiKey: NEMNPWINWMHUMR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodo-benzamide
  • Rafoxanide
  • 22662-39-1
  • NCGC00160556-01
  • D05693
  • Rafoxanide (USAN)
  • 3'-Chloro-4'-(p-chlorophenoxy)-3,5-diiodosalicylanilide
  • AI3-29020
  • BRN 2228187
  • Benzamide, N-(3-chloro-4-(4-chlorophenoxy)phenyl)-2-hydroxy-3,5-diiodo-
  • Bovanide
  • Disalan
  • Duofas
  • EINECS 245-148-9
  • Flukanide
  • MK-990
  • NSC 355278
  • Rafoxanida [INN-Spanish]
  • Rafoxanide [USAN:BAN:INN]
  • Rafoxanidum [INN-Latin]
  • Ranide
  • Ranide, veterinary
  • Salicylanilide, 3'-chloro-4'-(p-chlorophenoxy)-3,5-diiodo-
  • ST011974
  • 3'-Chlor-4'-(4-chlorphenoxy)-3,5-diiodsalicylanilid
  • 3'-Chloro-4'-(p-chlorophenoxy)-3, 5-diiodosalicylanilide
  • AIDS-129585
  • AIDS129585
  • Benzamide, {N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,} 5-diiodo-
  • N-(3-Chloro-4-(4-chlorophenoxy)phenyl)-2-hydroxy-3,5-diiodobenzamide
  • NSC355278
  • Benzamide, N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodo-
  • WLN: QR BI DI FVMR CG DOR DG
  • BAS 00336885
  • N-[3-Chloro-4-(4-chloro-phenoxy)-phenyl]-2-hydroxy-3,5-diiodo-benzamide
  • ZINC04181896

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Onchocerca volvulus References
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Macaaca fascicularis T-complex protein 1 subunit beta Starlite/ChEMBL No references
Human immunodeficiency virus 1 Envelope glycoprotein gp160 Starlite/ChEMBL No references
Onchocerca volvulus Chitinase Starlite/ChEMBL References
Rattus norvegicus Peripheral myelin protein 22 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) cuticular endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium berghei conserved Plasmodium protein, unknown function Get druggable targets OG5_130698 All targets in OG5_130698
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii hypothetical protein Get druggable targets OG5_130698 All targets in OG5_130698
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Putative endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania infantum chitinase Get druggable targets OG5_126929 All targets in OG5_126929
Schistosoma japonicum ko:K09494 T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein Get druggable targets OG5_130698 All targets in OG5_130698
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi conserved Plasmodium protein, unknown function Get druggable targets OG5_130698 All targets in OG5_130698
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Putative endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Onchocerca volvulus Putative endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Candida albicans chitinase similar to Ajellomyces capsulatus CTS1 Get druggable targets OG5_126929 All targets in OG5_126929
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) chitinase I Get druggable targets OG5_126929 All targets in OG5_126929
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) microfilarial chitinase Get druggable targets OG5_126929 All targets in OG5_126929
Onchocerca volvulus Putative endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii putative T-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Plasmodium vivax hypothetical protein, conserved Get druggable targets OG5_130698 All targets in OG5_130698
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium berghei T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trichomonas vaginalis chaperonin-60kD, ch60, putative Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 Get druggable targets OG5_130698 All targets in OG5_130698
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Entamoeba histolytica T-complex protein 1 beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania major chitinase Get druggable targets OG5_126929 All targets in OG5_126929
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130698 All targets in OG5_130698
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Possible chitinase Get druggable targets OG5_126929 All targets in OG5_126929
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 Get druggable targets OG5_130698 All targets in OG5_130698
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii t-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Entamoeba histolytica chitinase, putative Get druggable targets OG5_126929 All targets in OG5_126929
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis T-complex protein beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130698 All targets in OG5_130698
Cryptosporidium hominis TCP-1/cpn60 chaperonin-related protein Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium yoelii Arabidopsis thaliana At1g02330/T6A9_12-related Get druggable targets OG5_130698 All targets in OG5_130698
Onchocerca volvulus Get druggable targets OG5_130698 All targets in OG5_130698
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Putative endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium falciparum T-complex protein 1 subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans chitinase similar to Ajellomyces capsulatus CTS1 Get druggable targets OG5_126929 All targets in OG5_126929
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) Get druggable targets OG5_127730 All targets in OG5_127730
Neospora caninum hypothetical protein Get druggable targets OG5_130698 All targets in OG5_130698
Plasmodium knowlesi T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Neospora caninum TCP-1/cpn60 family chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans chitinase/cellulase Get druggable targets OG5_126929 All targets in OG5_126929
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania donovani chitinase Get druggable targets OG5_126929 All targets in OG5_126929
Onchocerca volvulus Get druggable targets OG5_130698 All targets in OG5_130698
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans chitinase/cellulase Get druggable targets OG5_126929 All targets in OG5_126929
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium falciparum conserved protein, unknown function Get druggable targets OG5_130698 All targets in OG5_130698
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum IPR010756,Hepatocellular carcinoma-associated antigen 59,domain-containing Get druggable targets OG5_130698 All targets in OG5_130698
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum GroEL-like chaperone (ATpase); T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126929 All targets in OG5_126929
Brugia malayi Endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130698 All targets in OG5_130698
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Giardia lamblia TCP-1 chaperonin subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.6 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 604 aa 22.9 %
Trypanosoma brucei gambiense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Echinococcus granulosus T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 34.0 %
Cryptosporidium hominis CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 536 aa 28.4 %
Schistosoma mansoni chaperonin containing t-complex protein 1 eta subunit tcph T-complex protein 1 subunit beta   535 aa 536 aa 32.8 %
Entamoeba histolytica chaperonin-containing TCP-1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 550 aa 23.5 %
Giardia lamblia TCP-1 chaperonin subunit eta T-complex protein 1 subunit beta   535 aa 543 aa 32.0 %
Echinococcus multilocularis chaperonin containing TCP1, subunit 5 (epsilon) T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Plasmodium berghei T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Cryptosporidium parvum putative T complex chaperonin T-complex protein 1 subunit beta   535 aa 546 aa 25.1 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Leishmania donovani T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Echinococcus granulosus chaperonin containing TCP1 subunit 5 epsilon T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Leishmania braziliensis chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Plasmodium yoelii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 523 aa 30.0 %
Plasmodium berghei T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 539 aa 34.1 %
Brugia malayi T-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 529 aa 28.4 %
Leishmania mexicana chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.6 %
Leishmania donovani T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Trypanosoma brucei gambiense T-complex protein 1, eta subunit, putative,t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.4 %
Trypanosoma brucei gambiense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Plasmodium berghei T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 523 aa 30.2 %
Cryptosporidium hominis chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.9 %
Cryptosporidium hominis CCTepsilon subunit T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Mycobacterium tuberculosis 60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (a T-complex protein 1 subunit beta   535 aa 565 aa 23.5 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 579 aa 23.1 %
Echinococcus granulosus T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 517 aa 27.1 %
Brugia malayi T-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 534 aa 35.6 %
Leishmania major chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.3 %
Leishmania infantum T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Leishmania braziliensis T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Plasmodium knowlesi T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 33.7 %
Leishmania braziliensis T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 29.1 %
Giardia lamblia TCP-1 chaperonin subunit epsilon T-complex protein 1 subunit beta   535 aa 535 aa 31.6 %
Plasmodium vivax T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Leishmania mexicana chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.3 %
Entamoeba histolytica chaperonin containing TCP-1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 508 aa 32.7 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 561 aa 23.0 %
Drosophila melanogaster CG8351 gene product from transcript CG8351-RA T-complex protein 1 subunit beta   535 aa 527 aa 32.3 %
Cryptosporidium hominis t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium yoelii putative chaperonin T-complex protein 1 subunit beta   535 aa 497 aa 22.7 %
Leishmania infantum T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Plasmodium vivax heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 540 aa 21.9 %
Brugia malayi T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 502 aa 26.3 %
Echinococcus multilocularis t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Toxoplasma gondii T-complex protein 1 delta subunit T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Theileria parva T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 522 aa 32.4 %
Leishmania braziliensis T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Leishmania mexicana T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.2 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Plasmodium vivax T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.3 %
Trypanosoma brucei T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Leishmania donovani chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 542 aa 27.7 %
Babesia bovis T-complex protein 1 zeta subunit T-complex protein 1 subunit beta   535 aa 532 aa 26.7 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.4 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Cryptosporidium hominis T-complex protein 1 T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 533 aa 33.8 %
Loa Loa (eye worm) CCT-5 protein T-complex protein 1 subunit beta   535 aa 521 aa 31.3 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 528 aa 20.8 %
Giardia lamblia TCP-1 chaperonin subunit alpha T-complex protein 1 subunit beta   535 aa 528 aa 32.6 %
Neospora caninum Thermosome subunit, related T-complex protein 1 subunit beta   535 aa 527 aa 31.3 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Toxoplasma gondii TCP-1 chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 26.9 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 575 aa 23.1 %
Trichomonas vaginalis chaperonin-60kD, ch60, putative T-complex protein 1 subunit beta   535 aa 538 aa 33.6 %
Toxoplasma gondii T-complex protein 1, epsilon subunit (TCP-1-epsilon), putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Onchocerca volvulus Integrator complex subunit 3 homolog T-complex protein 1 subunit beta   535 aa 534 aa 35.8 %
Plasmodium falciparum T-complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 539 aa 23.4 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 33.5 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 545 aa 29.7 %
Toxoplasma gondii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 531 aa 29.2 %
Cryptosporidium parvum TCP-1/cpn60 chaperonin family, T-complex protein subunit 7 (eta) T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 549 aa 35.7 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Trypanosoma cruzi chaperonin/T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 30.9 %
Schistosoma mansoni chaperonin containing t-complex protein 1 delta subunit tcpd T-complex protein 1 subunit beta   535 aa 530 aa 32.8 %
Babesia bovis HSP60 fold T-complex protein 1, putative T-complex protein 1 subunit beta   535 aa 497 aa 28.0 %
Plasmodium falciparum T-complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 522 aa 29.9 %
Trypanosoma brucei T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Plasmodium yoelii chaperonin, 60 kDa T-complex protein 1 subunit beta   535 aa 530 aa 34.9 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 561 aa 27.1 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Schistosoma mansoni chaperonin containing t-complex protein 1 gamma subunit tcpg T-complex protein 1 subunit beta   535 aa 552 aa 29.7 %
Plasmodium berghei T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 526 aa 25.7 %
Schistosoma mansoni chaperonin containing t-complex protein 1 zeta subunit tcpz T-complex protein 1 subunit beta   535 aa 544 aa 26.3 %
Theileria parva T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 27.1 %
Echinococcus granulosus T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Leishmania infantum chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Leishmania major T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.8 %
Trypanosoma brucei gambiense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Plasmodium vivax T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Leishmania infantum chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Brugia malayi T-complex protein 1, eta subunit T-complex protein 1 subunit beta   535 aa 534 aa 33.1 %
Trypanosoma congolense t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Trypanosoma congolense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.4 %
Dictyostelium discoideum chaperonin containing TCP1 theta subunit T-complex protein 1 subunit beta   535 aa 501 aa 27.1 %
Entamoeba histolytica hypothetical protein T-complex protein 1 subunit beta   535 aa 516 aa 22.5 %
Trypanosoma brucei gambiense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Entamoeba histolytica T-complex protein 1 theta subunit, putative T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 550 aa 32.9 %
Leishmania infantum T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.4 %
Leishmania donovani T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.8 %
Leishmania mexicana T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 35.1 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Cryptosporidium parvum conserved probable chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.7 %
Echinococcus multilocularis T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Schistosoma mansoni T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) T-complex protein 1 subunit beta   535 aa 552 aa 33.5 %
Plasmodium yoelii T-complex protein 1 epsilon subunit T-complex protein 1 subunit beta   535 aa 508 aa 32.9 %
Dictyostelium discoideum chaperonin containing TCP1 zeta subunit T-complex protein 1 subunit beta   535 aa 523 aa 26.6 %
Drosophila melanogaster T-complex Chaperonin 5 T-complex protein 1 subunit beta   535 aa 506 aa 34.6 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Neospora caninum hypothetical protein T-complex protein 1 subunit beta   535 aa 531 aa 29.0 %
Plasmodium knowlesi T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 526 aa 31.0 %
Theileria parva T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 580 aa 33.3 %
Babesia bovis T-complex protein 1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 32.6 %
Trypanosoma brucei T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Brugia malayi hypothetical protein Peripheral myelin protein 22   160 aa 129 aa 25.6 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 29.8 %
Giardia lamblia TCP-1 chaperonin subunit zeta T-complex protein 1 subunit beta   535 aa 516 aa 24.8 %
Trichomonas vaginalis rubisco subunit binding-protein alpha subunit, ruba, putative T-complex protein 1 subunit beta   535 aa 580 aa 23.3 %
Entamoeba histolytica T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 29.9 %
Brugia malayi T-complex protein 1, epsilon subunit T-complex protein 1 subunit beta   535 aa 513 aa 31.4 %
Entamoeba histolytica T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 31.6 %
Trypanosoma cruzi chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 547 aa 26.0 %
Babesia bovis t-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Toxoplasma gondii T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.8 %
Leishmania major chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 533 aa 28.3 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Dictyostelium discoideum chaperonin containing TCP1 eta subunit T-complex protein 1 subunit beta   535 aa 528 aa 33.5 %
Leishmania donovani chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.5 %
Cryptosporidium parvum T complex chaperonin T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Trypanosoma cruzi chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 528 aa 33.0 %
Leishmania braziliensis chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Schistosoma mansoni chaperonin containing t-complex protein 1 epsilon subunit tcpe T-complex protein 1 subunit beta   535 aa 505 aa 33.9 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.2 %
Echinococcus multilocularis T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 27.1 %
Trypanosoma brucei gambiense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 550 aa 32.0 %
Trypanosoma brucei gambiense T-complex protein 1, theta subunit, putative,CCT-theta, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Plasmodium falciparum T-complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 546 aa 34.4 %
Leishmania mexicana T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.6 %
Loa Loa (eye worm) T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 514 aa 26.5 %
Dictyostelium discoideum chaperonin containing TCP1 alpha subunit T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Plasmodium vivax T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Trypanosoma cruzi T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 29.5 %
Neospora caninum GL18351, related T-complex protein 1 subunit beta   535 aa 530 aa 26.2 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Echinococcus granulosus t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Leishmania braziliensis chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 542 aa 26.2 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Trypanosoma brucei T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Theileria parva T-complex protein 1, alpha subunit , putative T-complex protein 1 subunit beta   535 aa 527 aa 34.9 %
Leishmania infantum T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Schistosoma japonicum ko:K09493 T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 585 aa 31.5 %
Trypanosoma congolense T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 28.6 %
Leishmania donovani chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Plasmodium falciparum T-complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 542 aa 34.9 %
Leishmania major T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.3 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 547 aa 32.7 %
Giardia lamblia TCP-1 chaperonin subunit gamma T-complex protein 1 subunit beta   535 aa 561 aa 29.8 %
Leishmania donovani T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Schistosoma japonicum ko:K09498 T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 552 aa 25.7 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Cryptosporidium parvum putative t-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 545 aa 28.3 %
Giardia lamblia TCP-1 chaperonin subunit theta T-complex protein 1 subunit beta   535 aa 563 aa 25.2 %
Toxoplasma gondii T-complex protein 1 eta subunit T-complex protein 1 subunit beta   535 aa 546 aa 33.9 %
Trypanosoma brucei T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Plasmodium knowlesi T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 544 aa 23.5 %
Dictyostelium discoideum chaperonin containing TCP1 epsilon subunit T-complex protein 1 subunit beta   535 aa 520 aa 34.4 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 546 aa 33.7 %
Theileria parva chaperonin 60 kDa, putative T-complex protein 1 subunit beta   535 aa 544 aa 26.1 %
Trypanosoma cruzi T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Leishmania major chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.1 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, beta subunit, tcpb, putative T-complex protein 1 subunit beta   535 aa 541 aa 35.5 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 549 aa 20.6 %
Trypanosoma cruzi T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 29.7 %
Entamoeba histolytica chaperonin containing TCP-1 delta subunit, putative T-complex protein 1 subunit beta   535 aa 531 aa 30.7 %
Plasmodium knowlesi T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.1 %
Toxoplasma gondii T complex chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.0 %
Babesia bovis TCP-1/cpn60 chaperonin family protein T-complex protein 1 subunit beta   535 aa 538 aa 30.5 %
Trypanosoma congolense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 32.2 %
Echinococcus multilocularis T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Leishmania major T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.5 %
Echinococcus granulosus T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.5 %
Leishmania major T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 28.8 %
Trypanosoma congolense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 521 aa 29.6 %
Leishmania mexicana chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 538 aa 26.8 %
Schistosoma japonicum ko:K09496 T-complex protein 1 subunit delta, putative T-complex protein 1 subunit beta   535 aa 533 aa 32.1 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, epsilon subunit, tcpe, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Leishmania infantum chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.7 %
Plasmodium yoelii T-complex protein 1 T-complex protein 1 subunit beta   535 aa 534 aa 26.2 %
Schistosoma mansoni chaperonin containing t-complex protein 1 theta subunit tcpq T-complex protein 1 subunit beta   535 aa 515 aa 27.2 %
Trypanosoma congolense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 525 aa 34.1 %
Cryptosporidium parvum t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Trypanosoma brucei T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.4 %
Babesia bovis heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 530 aa 22.3 %
Plasmodium knowlesi T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.7 %
Plasmodium vivax T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 539 aa 22.4 %
Schistosoma japonicum ko:K09499 T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Brugia malayi T-complex protein 1, zeta subunit T-complex protein 1 subunit beta   535 aa 517 aa 27.7 %
Leishmania braziliensis T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Schistosoma japonicum ko:K09497 T-complex protein 1 subunit epsilon, putative T-complex protein 1 subunit beta   535 aa 505 aa 33.5 %
Plasmodium falciparum T-complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 23.1 %
Plasmodium berghei T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 537 aa 23.5 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, gamma subunit, tcpg, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0044 0.0044
Onchocerca volvulus 0.0043 0.0693 0.1178
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0047 0.0045
Schistosoma mansoni hypothetical protein 0.0144 0.2777 0.2777
Loa Loa (eye worm) hypothetical protein 0.0038 0.057 0.0989
Mycobacterium ulcerans chitinase/cellulase 0.0078 0.1396 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0047 0.0047
Loa Loa (eye worm) microfilarial chitinase 0.0088 0.1623 0.2885
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0667 0.1054
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0693 0.0999
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0046
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0156 0.0156
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0047 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0819 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.057 0.6789
Brugia malayi follicle stimulating hormone receptor 0.028 0.5573 1
Entamoeba histolytica hypothetical protein 0.0042 0.0667 0.3719
Onchocerca volvulus 0.0035 0.0511 0.0859
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0555 0.0555
Toxoplasma gondii ABC1 family protein 0.0043 0.0693 0.2298
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0399 0.068
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0047 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0819 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0555 0.0555
Leishmania major T-complex protein 1, beta subunit, putative 0.0029 0.0399 0.1601
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0156 0.0242
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0047 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0046
Entamoeba histolytica chitinase, putative 0.0091 0.1673 1
Brugia malayi Uncoordinated protein 44 0.0017 0.0153 0.0238
Echinococcus granulosus cpg binding protein 0.0037 0.0552 0.0552
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0047 0.0046
Trichomonas vaginalis set domain proteins, putative 0.0287 0.572 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.5534 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0047 0.0047
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0047 0.0047
Echinococcus multilocularis transcription factor btf3 0.0042 0.0667 0.0667
Trichomonas vaginalis DNA polymerase eta, putative 0.005 0.0819 0.1324
Brugia malayi hypothetical protein 0.0148 0.2851 0.5097
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0667 0.1163
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0667 0.3719
Loa Loa (eye worm) chitinase I 0.0091 0.1673 0.2975
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0819 0.5645
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0156 0.0156
Brugia malayi nuclear hormone receptor 0.0012 0.0047 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0047 0.0046
Schistosoma mansoni hypothetical protein 0.0494 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0156 0.0242
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0047 0.0047
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0047 0.0046
Onchocerca volvulus 0.0043 0.0693 0.1178
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0047 0.0047
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0819 0.5645
Brugia malayi Pre-SET motif family protein 0.0037 0.0555 0.0962
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0047 0.0046
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0667 0.2202
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0047 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0819 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0552 0.0552
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0144 0.2777 0.2777
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0819 1
Onchocerca volvulus Putative endochitinase 0.0013 0.0071 0.0088
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0693 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.057 0.6789
Brugia malayi Protein kinase domain containing protein 0.0017 0.0153 0.0238
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0047 0.0047
Onchocerca volvulus 0.0144 0.2777 0.4832
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0029 0.0399 0.0579
Mycobacterium tuberculosis Conserved protein 0.0043 0.0693 0.0999
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0029 0.0399 0.0399
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0693 0.0693
Plasmodium falciparum conserved protein, unknown function 0.0144 0.2777 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0047 0.0047
Schistosoma mansoni cpg binding protein 0.0037 0.0552 0.0552
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0047 0.0046
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0153 0.0232
Echinococcus granulosus Ankyrin 0.0018 0.0156 0.0156
Schistosoma mansoni coup transcription factor 0.0012 0.0047 0.0047
Echinococcus multilocularis geminin 0.0205 0.4022 0.4022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0071 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0819 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0693 0.8097
Trichomonas vaginalis chaperonin, putative 0.0029 0.0399 0.0579
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.032 0.1085
Loa Loa (eye worm) hypothetical protein 0.0018 0.0156 0.0244
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0693 0.11
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0819 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0047 0.0047
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0156 0.0527
Onchocerca volvulus Putative endochitinase 0.0102 0.1899 0.3294
Onchocerca volvulus Putative endochitinase 0.0102 0.1899 0.3294
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0153 0.0153
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0693 0.11
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0153 0.0238
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0511 0.0883
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0144 0.2777 0.4963
Brugia malayi polk-prov protein 0.0038 0.057 0.0989
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0555 0.1788
Echinococcus multilocularis Ankyrin 0.0018 0.0156 0.0156
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0041 0.0036
Brugia malayi Endochitinase 0.0102 0.1899 0.3383
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0029 0.0399 0.2044
Echinococcus multilocularis dna polymerase eta 0.0017 0.0156 0.0156
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0047 0.0047
Onchocerca volvulus Putative endochitinase 0.0102 0.1899 0.3294
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0819 1
Echinococcus granulosus geminin 0.0205 0.4022 0.4022
Onchocerca volvulus Putative chitinase 0.0013 0.0071 0.0088
Brugia malayi Death domain containing protein 0.0017 0.0153 0.0238
Brugia malayi ecdysteroid receptor 0.0012 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0043 0.0693 0.121
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0047 0.0047
Mycobacterium ulcerans hypothetical protein 0.0043 0.0693 0.4692
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0044 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0156 0.0242
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0047 0.0046
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0044 0.0041
Schistosoma mansoni cpg binding protein 0.0035 0.0511 0.0511
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0819 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0693 0.121
Loa Loa (eye worm) hypothetical protein 0.0043 0.0693 0.121
Brugia malayi Endochitinase 0.0013 0.0071 0.009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0047 0.0046
Brugia malayi Glycosyl hydrolases family 18 protein 0.0013 0.0071 0.009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0047 0.0047
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0029 0.0399 0.121
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0047 0.0047
Brugia malayi beta-NAC-like protein 0.0042 0.0667 0.1163
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0693 0.0999
Brugia malayi endochitinase 0.0102 0.1899 0.3383
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0693 0.8372
Echinococcus granulosus transcription factor btf3 0.0042 0.0667 0.0667
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0043 0.0693 0.121
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0156 0.1445
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0693 0.2298
Echinococcus granulosus death domain containing protein 0.0017 0.0153 0.0153
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.1632 0.1632
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0047 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0208 0.2122
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0144 0.2777 0.2777
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.032 0.3568
Mycobacterium ulcerans chitinase/cellulase 0.0078 0.1396 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0047 0.0046
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0029 0.0399 0.4576
Mycobacterium tuberculosis Conserved protein 0.0043 0.0693 0.0999
Echinococcus multilocularis dna polymerase kappa 0.005 0.0819 0.0819
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0399 0.0399
Brugia malayi beta-lactamase family protein 0.0043 0.0693 0.121
Onchocerca volvulus 0.0037 0.0555 0.0936
Loa Loa (eye worm) hypothetical protein 0.0013 0.0071 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0208 0.2122
Schistosoma mansoni cpg binding protein 0.0037 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0037 0.0555 0.0962
Onchocerca volvulus Huntingtin homolog 0.0148 0.2851 0.4963
Echinococcus granulosus dna polymerase kappa 0.005 0.0819 0.0819
Schistosoma mansoni transcription factor btf3 0.0042 0.0667 0.0667
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.5573 1
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0667 0.7705
Loa Loa (eye worm) hypothetical protein 0.0144 0.2777 0.4963
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0693 0.11
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0555 0.0555
Schistosoma mansoni netrin receptor unc5 0.0017 0.0153 0.0153
Toxoplasma gondii hypothetical protein 0.0144 0.2777 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0693 0.4692
Onchocerca volvulus Putative endochitinase 0.0091 0.1673 0.2897
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0693 0.121
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0043 0.0693 0.121
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0156 0.0242
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0046
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0693 0.0999
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0047 0.0046
Mycobacterium ulcerans beta-lactamase 0.0043 0.0693 0.4692
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0819 1
Brugia malayi Glycosyl hydrolases family 18 protein 0.0013 0.0071 0.009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0047 0.0047
Leishmania major chitinase 0.0091 0.1673 1
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0819 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0046
Leishmania major basic transcription factor 3a, putative 0.0042 0.0667 0.3369
Brugia malayi steroid hormone receptor 0.0012 0.0047 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0047 0.0046
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0693 0.11
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0047 0.0045
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0693 0.0999
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0819 1
Loa Loa (eye worm) glycosyl hydrolase family 18 protein 0.0013 0.0071 0.009
Schistosoma mansoni hypothetical protein 0.0062 0.1085 0.1085
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0819 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0047 0.0047
Trypanosoma brucei unspecified product 0.0042 0.0655 0.7878
Schistosoma mansoni DNA polymerase eta 0.0017 0.0156 0.0156
Brugia malayi CXXC zinc finger family protein 0.0035 0.0511 0.0883
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0047 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0043 0.0693 0.121
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0047 0.0046
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0399 0.0399
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0693 0.0999
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.005 0.0819 0.1324
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.032 0.0306
Brugia malayi nuclear receptor NHR-88 0.0012 0.0047 0.0046
Onchocerca volvulus 0.0043 0.0693 0.1178
Onchocerca volvulus 0.0287 0.5723 1
Onchocerca volvulus 0.0144 0.2777 0.4832
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0047 0.0046
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0148 0.2851 0.5097
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.1632 0.1632
Brugia malayi beta-lactamase 0.0043 0.0693 0.121
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0693 0.0693
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0047 0.0047
Onchocerca volvulus 0.0012 0.0047 0.0045
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0153 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0667 0.1054
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0047 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0693 0.8097
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0043 0.0693 0.121
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0047 0.0046
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0555 0.0555
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0693 0.121
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0693 0.0693
Onchocerca volvulus Putative endochitinase 0.0091 0.1673 0.2897
Leishmania major hypothetical protein, conserved 0.0043 0.0693 0.3541
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0693 0.0999
Schistosoma mansoni chitinase 0.0013 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0078 0.1396 0.2477
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0156 0.0156
Brugia malayi endochitinase 0.0091 0.1673 0.2975
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0029 0.0399 0.0399
Echinococcus multilocularis Glycoside hydrolase, chitinase domain containing protein 1 0.0013 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0667 0.1054
Schistosoma mansoni hypothetical protein 0.0205 0.4022 0.4022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0047 0.0046
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0655 0.7878
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0555 0.0555
Mycobacterium leprae Probable lipase LipE 0.0043 0.0693 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0047 0.0047
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0399 0.068
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0153 0.0153
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.5003 0.8973
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0047 0.0047
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0047 0.0047
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0693 0.0999
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0208 0.2122
Brugia malayi hypothetical protein 0.0013 0.0071 0.009
Loa Loa (eye worm) hypothetical protein 0.0148 0.2851 0.5097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0238
Loa Loa (eye worm) hypothetical protein 0.0144 0.2777 0.4963
Brugia malayi beta-lactamase family protein 0.0043 0.0693 0.121
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.118 0.4097
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0667 0.2202
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0667 0.8037
Plasmodium falciparum T-complex protein 1 subunit beta 0.0029 0.0399 0.121
Onchocerca volvulus Huntingtin homolog 0.0148 0.2851 0.4963
Mycobacterium tuberculosis Possible chitinase 0.0078 0.1396 0.2307
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0512 0.0512
Loa Loa (eye worm) cuticular endochitinase 0.0091 0.1673 0.2975
Plasmodium vivax hypothetical protein, conserved 0.0144 0.2777 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0047 0.0047
Echinococcus granulosus Glycoside hydrolase chitinase domain containing protein 1 0.0013 0.0071 0.0071
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0693 0.4692
Giardia lamblia TCP-1 chaperonin subunit beta 0.0029 0.0399 1
Trichomonas vaginalis esterase, putative 0.0043 0.0693 0.11
Plasmodium vivax SET domain protein, putative 0.0037 0.0555 0.1788
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0047 0.0047
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0047 0.0047
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0667 0.7705
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0047 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0819 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0555 0.0555
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0029 0.0399 0.366
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.1342 0.1342
Toxoplasma gondii t-complex protein beta subunit 0.0029 0.0399 0.121
Brugia malayi hypothetical protein 0.0013 0.0071 0.009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0047 0.0046
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0047 0.0046
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0667 0.2202
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0047 0.0046
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0819 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0047 0.0046
Schistosoma mansoni hypothetical protein 0.0205 0.4022 0.4022
Mycobacterium tuberculosis Conserved protein 0.0043 0.0693 0.0999
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0555 0.0555
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0047 0.0047
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0153 0.0238
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0153 0.0153
Echinococcus granulosus dna polymerase eta 0.0017 0.0156 0.0156
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0693 0.0693
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0046
Mycobacterium ulcerans lipase LipD 0.0043 0.0693 0.4692
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0046
Loa Loa (eye worm) T-complex protein 1 0.0029 0.0399 0.068
Brugia malayi Pre-SET motif family protein 0.0252 0.5003 0.8973
Schistosoma mansoni hypothetical protein 0.0017 0.0153 0.0153
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0693 0.11
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0156 0.0156
Leishmania major DNA polymerase kappa, putative 0.0025 0.032 0.1085
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0819 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0046

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Induction of internalization of Frizzled1-GFP (unknown origin) expressed in human U2OS cells at 12.5 uM after 6 hrs by confocal microscopy ChEMBL. 23453073
Dose (functional) = 12.5 mg kg-1 In vitro for fasciolicidal activity against Fasciola hepatica infections in rats following s.c. administration. ChEMBL. 3965706
Drug uptake (ADMET) = 1.55 nmol/mg Drug accumulation in Caenorhabditis elegans at 10 uM after 6 hrs by LC-MS analysis ChEMBL. 24918716
EC50 (functional) < 0.06 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
IC50 (binding) = 0.34 uM Inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate after 10 mins by microplate reader analysis ChEMBL. 24918716
IC50 (binding) = 19.7 uM PUBCHEM_BIOASSAY: uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1991, AID434967] ChEMBL. No reference
Inhibition (binding) Inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate at 10 uM after 10 mins by microplate reader analysis ChEMBL. 24918716
Inhibition (functional) = 84 % Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 1 uM for 24 hrs measured until 6 days by using inverted microscopic analysis in presence of PBMC ChEMBL. 24918716
Ki (binding) = 0.13 uM Competitive inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate after 10 mins by microplate reader analysis ChEMBL. 24918716
Potency (functional) 1.1582 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 1.5101 uM PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 7.5624 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.1815 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 13.3714 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.1968 uM PUBCHEM_BIOASSAY: Biochemical firefly luciferase enzyme assay for NPC. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 33.4889 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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