Detailed information for compound 546286

Basic information

Technical information
  • TDR Targets ID: 546286
  • Name: nybomycin
  • MW: 298.293 | Formula: C16H14N2O4
  • H donors: 1 H acceptors: 3 LogP: -0.47 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1cc(=O)n(c2c1cc1c(C)cc(=O)n3c1c2OC3)C
  • InChi: 1S/C16H14N2O4/c1-8-3-13(21)18-7-22-16-14-11(5-10(8)15(16)18)9(6-19)4-12(20)17(14)2/h3-5,19H,6-7H2,1-2H3
  • InChiKey: HKMUGCUFXWTNSP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 26326-47-6
  • 30408-30-1
  • 8-(Hydroxymethyl)-6,11-dimethyl-4H-[1,3]oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11H)-dione
  • AIDS-130803
  • AIDS130803
  • NSC613948
  • 8-(Hydroxymethyl)-6,11-dimethyl-4H-(1,3)oxazolo(5,4,3-ij)pyrido(3,2-g)quinoline-4,10(11H)-dione
  • NSC 613948
  • NCI60_004922
  • 8,9-Dihydro-4-(hydroxymethyl)-6,9-dimethyl-2,8-dioxopyrido(3,2-g)quinoline-1(2H)-carboxaldehyde

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0146 0.058 0.4527
Echinococcus multilocularis geminin 0.0346 0.1536 0.1536
Mycobacterium ulcerans hypothetical protein 0.062 0.2846 1
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0226 0.1753
Schistosoma mansoni alpha-glucosidase 0.0267 0.1157 0.1247
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0169 0.0689 0.0689
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0081 0.0267 0.0589
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0165 0.0668 0.1478
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0056 0.0426
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0203 0.0852 0.6656
Leishmania major glycerol uptake protein, putative 0.0169 0.0689 0.5381
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.0209 0.0459
Toxoplasma gondii hypothetical protein 0.0038 0.0061 0.0735
Loa Loa (eye worm) hypothetical protein 0.0429 0.1933 0.1931
Toxoplasma gondii hypothetical protein 0.0047 0.0105 0.129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0141 0.0555 0.0598
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0088 0.0301 0.3749
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0067 0.0198 0.248
Trypanosoma brucei metacaspase MCA2 0.0026 0.0002 0.0003
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0278 0.0277
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0185 0.0183
Echinococcus multilocularis carbonic anhydrase 0.011 0.0406 0.0406
Echinococcus multilocularis ornithine aminotransferase 0.0088 0.0301 0.0301
Leishmania major DNA polymerase eta, putative 0.0047 0.0103 0.079
Trichomonas vaginalis transmembrane protein nessy, putative 0.0169 0.0689 0.1524
Echinococcus granulosus GPCR family 2 0.0031 0.0026 0.0026
Schistosoma mansoni lipoxygenase 0.0059 0.016 0.0172
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0173 0.0186
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0185 0.1435
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.044 0.044
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0049 0.0113 0.0111
Trichomonas vaginalis set domain proteins, putative 0.0968 0.4511 1
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0043 0.0041
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0141 0.0555 0.0555
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.062 0.2846 1
Schistosoma mansoni carbonic anhydrase 0.011 0.0406 0.0437
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0002 0.0001
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0043 0.0041
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0146 0.058 0.4527
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0274 0.1192 0.119
Mycobacterium tuberculosis Probable reductase 0.0438 0.1978 0.6901
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0379 0.0837
Onchocerca volvulus Huntingtin homolog 0.0119 0.0447 0.0987
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0376 0.1677 0.1677
Echinococcus granulosus polycomb protein SCMH1 0.0093 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0429 0.1933 0.1931
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0061 0.0735
Toxoplasma gondii hypothetical protein 0.0169 0.0689 0.8621
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0226 0.0243
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.0449 0.3502
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0071 0.0219 0.0219
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0111
Mycobacterium ulcerans DNA polymerase IV 0.0097 0.0342 0.1068
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0067 0.0198 0.1535
Trypanosoma brucei protein kinase, putative 0.0051 0.0124 0.0958
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0165 0.0668 0.8357
Brugia malayi mbt repeat family protein 0.0093 0.0326 0.0325
Loa Loa (eye worm) hypothetical protein 0.0072 0.0226 0.0224
Schistosoma mansoni myelin transcription factor 1 myt1 0.0106 0.0388 0.0418
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0169 0.0689 0.8621
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.0444 0.1432
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0065 0.0192 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0689 0.1524
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0026 0.0026
Trypanosoma cruzi GUP1, putative 0.0169 0.0689 0.5381
Schistosoma mansoni hypothetical protein 0.0048 0.0111 0.0119
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0197 0.0197
Schistosoma mansoni cpg binding protein 0.0098 0.0349 0.0377
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Brugia malayi MBOAT family protein 0.0169 0.0689 0.0687
Trypanosoma cruzi glycerol uptake protein, putative 0.0169 0.0689 0.5381
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0067 0.0198 0.2456
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0713 0.3289 0.3289
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0015 0.0016
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0043 0.0321
Brugia malayi RNA binding protein 0.0061 0.0173 0.0171
Echinococcus multilocularis dna polymerase kappa 0.0097 0.0342 0.0342
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0169 0.0689 0.0689
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0141 0.0555 0.0598
Echinococcus granulosus SAM and MBT domain containing protein 0.0093 0.0326 0.0326
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0026 0.0002 0.0002
Plasmodium vivax glutathione reductase, putative 0.0192 0.0799 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Schistosoma mansoni hypothetical protein 0.0346 0.1536 0.1656
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0065 0.0192 0.2379
Entamoeba histolytica deoxycytidyl transferase, putative 0.0071 0.0219 0.3159
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0169 0.0689 0.0743
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0169 0.0689 0.0689
Leishmania major hypothetical protein, conserved 0.0065 0.0192 0.1487
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0165 0.0668 0.5216
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0006 0.0005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.0035 0.0035
Entamoeba histolytica vacuolar protein sorting 26 0.0169 0.0689 1
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0116 0.0897
Loa Loa (eye worm) hypothetical protein 0.0096 0.0337 0.0335
Schistosoma mansoni carbonic anhydrase-related 0.011 0.0406 0.0437
Schistosoma mansoni cpg binding protein 0.0091 0.0315 0.034
Leishmania major glycerol uptake protein, putative 0.0169 0.0689 0.5381
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0274 0.1192 0.1192
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0002 0.0001
Schistosoma mansoni lozenge 0.0054 0.0137 0.0147
Toxoplasma gondii hypothetical protein 0.0038 0.0061 0.0735
Schistosoma mansoni transcription factor LCR-F1 0.0142 0.0559 0.0602
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0002 0.0001
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0067 0.0198 0.1535
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0169 0.0689 0.0689
Loa Loa (eye worm) hypothetical protein 0.0042 0.0079 0.0077
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.0192 0.0533
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0169 0.1307
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0067 0.0198 0.1535
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0002 0.0001
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Echinococcus multilocularis lamin 0.0027 0.0006 0.0006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0142 0.0559 0.0559
Leishmania major hypothetical protein, conserved 0.0072 0.0226 0.1753
Onchocerca volvulus 0.0072 0.0226 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.058 0.1283
Schistosoma mansoni hypothetical protein 0.0031 0.0026 0.0028
Onchocerca volvulus 0.0072 0.0226 0.0497
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0173 0.0186
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0053 0.0131 0.0129
Brugia malayi MBOAT family protein 0.0169 0.0689 0.0687
Echinococcus multilocularis caspase 8 0.0026 0.0002 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.0444 0.0479
Toxoplasma gondii hypothetical protein 0.0104 0.0379 0.473
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0108 0.083
Echinococcus granulosus thioredoxin glutathione reductase 0.0192 0.0799 0.0799
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0067 0.0198 0.2315
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0209 0.1619
Echinococcus multilocularis pyruvate kinase 0.0027 0.0008 0.0008
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0061 0.0064
Trichomonas vaginalis mercuric reductase, putative 0.0067 0.0198 0.0435
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Schistosoma mansoni lamin 0.0027 0.0006 0.0007
Echinococcus granulosus ornithine aminotransferase 0.0088 0.0301 0.0301
Loa Loa (eye worm) inositol-1 0.0073 0.0229 0.0227
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.0209 0.0459
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0067 0.0198 0.0198
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.0192 0.0533
Entamoeba histolytica hypothetical protein 0.0142 0.0559 0.8105
Echinococcus granulosus o acyltransferase membrane bound domain 0.0169 0.0689 0.0689
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.011 0.0406 0.0404
Brugia malayi CXXC zinc finger family protein 0.0091 0.0315 0.0313
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0002 0.0001
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0438 0.1978 0.6901
Plasmodium falciparum phosphoglycerate kinase 0.0165 0.0668 0.8357
Giardia lamblia DINP protein human, muc B family 0.0077 0.025 0.3306
Plasmodium vivax ornithine aminotransferase, putative 0.0088 0.0301 0.3749
Echinococcus multilocularis sterol O acyltransferase 1 0.0169 0.0689 0.0689
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0229 0.282
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.0449 0.0992
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0088 0.0301 0.0921
Echinococcus multilocularis muscleblind protein 0.2115 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0067 0.0198 0.2315
Loa Loa (eye worm) hypothetical protein 0.0034 0.0043 0.0041
Trypanosoma brucei DNA polymerase IV, putative 0.0097 0.0342 0.2665
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0185 0.1435
Schistosoma mansoni bromodomain containing protein 0.007 0.0215 0.0231
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0106 0.0388 0.0388
Brugia malayi Pre-SET motif family protein 0.0124 0.0471 0.0469
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0229 0.0503
Loa Loa (eye worm) hypothetical protein 0.0097 0.0342 0.034
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0185 0.1435
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0067 0.0198 0.0196
Echinococcus multilocularis lysosomal alpha glucosidase 0.031 0.1364 0.1364
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0067 0.0198 0.0553
Schistosoma mansoni inositol monophosphatase 0.0073 0.0229 0.0247
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0088 0.0301 0.0921
Trypanosoma brucei Metacaspase-4 0.0026 0.0002 0.0003
Mycobacterium leprae Probable lipase LipE 0.0072 0.0226 0.0652
Trypanosoma cruzi GUP1, putative 0.0169 0.0689 0.5381
Echinococcus multilocularis Protein lozenge 0.0054 0.0137 0.0137
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0169 0.1307
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0026 0.0024
Echinococcus multilocularis thioredoxin glutathione reductase 0.0192 0.0799 0.0799
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Trypanosoma brucei glycerol uptake protein, putative 0.0169 0.0689 0.5381
Entamoeba histolytica phosphoglycerate kinase, putative 0.0165 0.0668 0.9694
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0056 0.0056
Leishmania major hypothetical protein, conserved 0.0169 0.0689 0.5381
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0043 0.0321
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0487 0.2212 0.7737
Mycobacterium ulcerans acetylornithine aminotransferase 0.0088 0.0301 0.0921
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0026 0.0026
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0146 0.058 0.0625
Loa Loa (eye worm) hypothetical protein 0.0038 0.0061 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0124 0.1302
Loa Loa (eye worm) hypothetical protein 0.0165 0.0668 0.0666
Schistosoma mansoni sterol O-acyltransferase 1 0.0169 0.0689 0.0743
Leishmania major DNA polymerase kappa, putative 0.0077 0.025 0.1939
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0226 0.0652
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0027 0.0009 0.0009
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0067 0.0198 0.0553
Echinococcus granulosus pyruvate kinase 0.0034 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0026 0.0026
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0119 0.0449 0.0449
Echinococcus multilocularis caspase 2 0.0026 0.0002 0.0002
Leishmania major metacaspase, putative 0.0026 0.0002 0.0003
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0229 0.3303
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0026 0.0024
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0226 0.0652
Schistosoma mansoni hypothetical protein 0.0576 0.2634 0.2838
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0056 0.0679
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0226 0.1753
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0038 0.0061 0.0064
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0124 0.1532
Loa Loa (eye worm) hypothetical protein 0.0106 0.0388 0.0386
Loa Loa (eye worm) hypothetical protein 0.0031 0.0026 0.0024
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0043 0.0091
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0067 0.0198 0.1535
Trypanosoma brucei carbonic anhydrase-like protein 0.0203 0.0852 0.6656
Loa Loa (eye worm) hypothetical protein 0.0072 0.0226 0.0224
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0118 0.0444 0.0444
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0088 0.0301 0.0921
Trypanosoma cruzi metacaspase, putative 0.0026 0.0002 0.0003
Echinococcus granulosus carbonic anhydrase 0.011 0.0406 0.0406
Echinococcus multilocularis GPCR, family 2 0.0031 0.0026 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0124 0.0958
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0065 0.0192 0.2379
Trichomonas vaginalis sucrase-isomaltase, putative 0.0069 0.0209 0.0459
Mycobacterium tuberculosis Conserved protein 0.0072 0.0226 0.0652
Trypanosoma brucei trypanothione reductase 0.0192 0.0799 0.6241
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0203 0.0852 0.6656
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0056 0.0426
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0065 0.0192 0.1487
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0038 0.0061 0.0064
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0229 0.1777
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0119 0.0449 0.0992
Schistosoma mansoni DNA polymerase eta 0.0096 0.0337 0.0363
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0002 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Leishmania major phosphoglycerate kinase B, cytosolic 0.0165 0.0668 0.5216
Loa Loa (eye worm) histone methyltransferase 0.0033 0.0035 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0173 0.0186
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0165 0.0668 0.223
Brugia malayi Glycosyl hydrolases family 31 protein 0.0069 0.0209 0.0207
Echinococcus multilocularis zinc finger protein 0.1795 0.8469 0.8469
Echinococcus multilocularis dnaJ subfamily B 0.0866 0.4022 0.4022
Schistosoma mansoni pyruvate kinase 0.0034 0.0043 0.0046
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0053 0.0131 0.0131
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.1279 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.011 0.0406 0.0404
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.3092 0.3092
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0119 0.0449 0.0484
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0088 0.0301 0.0921
Trypanosoma cruzi metacaspase, putative 0.0026 0.0002 0.0003
Trypanosoma brucei phosphoglycerate kinase 0.0165 0.0668 0.5216
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0026 0.0002 0.0002
Echinococcus granulosus phosphoglycerate kinase 1 0.0165 0.0668 0.0668
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0061 0.0064
Echinococcus granulosus neuropeptide receptor A26 0.0933 0.4346 0.4346
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0124 0.0272
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0015 0.0015
Mycobacterium tuberculosis Conserved protein 0.0072 0.0226 0.0652
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0061 0.0064
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0226 0.0652
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0229 0.2844
Loa Loa (eye worm) hypothetical protein 0.0053 0.0131 0.0129
Mycobacterium ulcerans glutaminase 0.0312 0.1374 0.475
Echinococcus multilocularis phosphoglycerate kinase 1 0.0165 0.0668 0.0668
Mycobacterium ulcerans hypothetical protein 0.0072 0.0226 0.0652
Plasmodium vivax SET domain protein, putative 0.0124 0.0471 0.5885
Plasmodium falciparum pyruvate kinase 0.0034 0.0043 0.0511
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0169 0.0689 0.0687
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0142 0.0559 0.0559
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.011 0.0406 0.0404
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0144 0.1114
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0124 0.0958
Brugia malayi MAP kinase sur-1 0.0051 0.0124 0.0122
Toxoplasma gondii GAF domain-containing protein 0.0038 0.0061 0.0735
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0274 0.1192 0.1285
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0119 0.0449 0.0992
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0226 0.0497
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0165 0.0668 0.8357
Loa Loa (eye worm) hypothetical protein 0.011 0.0406 0.0404
Trichomonas vaginalis esterase, putative 0.0072 0.0226 0.0497
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0146 0.058 0.058
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Leishmania major pyruvate kinase 0.0034 0.0043 0.0321
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0053 0.0131 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0146 0.058 0.0578
Toxoplasma gondii hypothetical protein 0.011 0.0406 0.5068
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0229 0.1777
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0146 0.058 0.0578
Loa Loa (eye worm) glutaminase 0.0312 0.1374 0.1373
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0169 0.0689 0.0689
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0065 0.0192 0.1487
Echinococcus multilocularis carbonic anhydrase 0.011 0.0406 0.0406
Schistosoma mansoni intermediate filament proteins 0.0027 0.0006 0.0007
Mycobacterium ulcerans lipase LipD 0.0072 0.0226 0.0652
Schistosoma mansoni hypothetical protein 0.0031 0.0026 0.0028
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.1964 0.9279 0.9279
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0274 0.1192 0.1285
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0124 0.0958
Echinococcus granulosus geminin 0.0346 0.1536 0.1536
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0056 0.0056
Leishmania major hypothetical protein, conserved 0.005 0.0116 0.0897
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0065 0.0192 0.0192
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0169 0.1307
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0067 0.0198 0.1535
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0067 0.0198 0.1535
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0067 0.0198 0.0213
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0043 0.0091
Onchocerca volvulus 0.0179 0.0738 0.1633
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0103 0.079
Loa Loa (eye worm) hepatopoietin HPO2 0.0065 0.0192 0.019
Brugia malayi Glycosyl hydrolases family 31 protein 0.031 0.1364 0.1362
Mycobacterium tuberculosis Probable oxidoreductase 0.0487 0.2212 0.7737
Echinococcus granulosus dna polymerase eta 0.0096 0.0337 0.0337
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0185 0.0185
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0002 0.0001
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0169 0.0689 0.0689
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0173 0.0171
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Schistosoma mansoni hypothetical protein 0.0866 0.4022 0.4335
Echinococcus granulosus tar DNA binding protein 0.0061 0.0173 0.0173
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0226 0.0226
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0192 0.0799 0.2697
Brugia malayi hypothetical protein 0.0032 0.0032 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0116 0.1434
Leishmania major glycerol uptake protein, putative 0.0169 0.0689 0.5381
Plasmodium falciparum glutathione reductase 0.0067 0.0198 0.2456
Echinococcus multilocularis neuropeptide s receptor 0.0933 0.4346 0.4346
Trypanosoma cruzi DNA polymerase eta, putative 0.0096 0.0337 0.2624
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0124 0.0122
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0197 0.0197
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0015 0.0015
Toxoplasma gondii NADPH-glutathione reductase 0.0067 0.0198 0.2456
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0056 0.0121
Schistosoma mansoni terminal deoxycytidyl transferase 0.0071 0.0219 0.0236
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0173 0.0186
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0056 0.0056
Schistosoma mansoni zinc finger protein 0.1964 0.9279 1
Schistosoma mansoni hypothetical protein 0.0031 0.0026 0.0028
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0226 0.0652
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0851 0.395 0.3948
Loa Loa (eye worm) hypothetical protein 0.0039 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0108 0.0106
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0119 0.0449 0.0449
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0226 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0689 0.1524
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0274 0.1192 0.1192
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0173 0.0171
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0106 0.0388 0.0388
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0043 0.0511
Loa Loa (eye worm) hypothetical protein 0.005 0.0116 0.0115
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0342 0.034
Loa Loa (eye worm) hypothetical protein 0.011 0.0406 0.0404
Schistosoma mansoni glutaminase 0.0312 0.1374 0.1481
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0226 0.0224
Brugia malayi hypothetical protein 0.0429 0.1933 0.1931
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0111 0.0109
Echinococcus granulosus histone acetyltransferase MYST2 0.0106 0.0388 0.0388
Echinococcus granulosus pyruvate kinase 0.0034 0.0043 0.0043
Trypanosoma brucei metacaspase 0.0026 0.0002 0.0003
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0173 0.0173
Brugia malayi ImpB/MucB/SamB family protein 0.0071 0.0219 0.0217
Loa Loa (eye worm) hypothetical protein 0.0072 0.0226 0.0224
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0076 0.0581
Trypanosoma cruzi DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Loa Loa (eye worm) beta-lactamase 0.0072 0.0226 0.0224
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1015 0.1015
Echinococcus multilocularis dna polymerase eta 0.0096 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0141 0.0555 0.0553
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0438 0.1978 0.6901
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.062 0.2846 0.6309
Toxoplasma gondii Erv1 / Alr family protein 0.0065 0.0192 0.2379
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Plasmodium vivax phosphoglycerate kinase, putative 0.0165 0.0668 0.8357
Giardia lamblia Phosphoglycerate kinase 0.0165 0.0668 1
Brugia malayi Augmenter of liver regeneration 0.0065 0.0192 0.019
Trichomonas vaginalis glutathione reductase, putative 0.0067 0.0198 0.0435
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.0169 0.1307
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.1964 0.9279 0.9279
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0278 0.0278
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0056 0.0048
Leishmania major phosphoglycerate kinase C, glycosomal 0.0165 0.0668 0.5216
Onchocerca volvulus 0.0169 0.0689 0.1524
Toxoplasma gondii histone lysine methyltransferase SET1 0.018 0.0738 0.924
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0069 0.0209 0.0459
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0056 0.0426
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0165 0.0668 0.223
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0006 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.0209 0.0459
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0076 0.0581
Trichomonas vaginalis maltase-glucoamylase, putative 0.0069 0.0209 0.0459
Echinococcus granulosus dna polymerase kappa 0.0097 0.0342 0.0342
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0088 0.0301 0.4128
Leishmania major glycerol uptake protein, putative 0.0169 0.0689 0.5381
Echinococcus multilocularis carbonic anhydrase 0.011 0.0406 0.0406
Echinococcus multilocularis caspase 0.0026 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0083 0.0278 0.0277
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0173 0.0186
Loa Loa (eye worm) MBOAT family protein 0.1964 0.9279 0.9279
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0542 0.4227
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0226 0.0652
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0009 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0116 0.1434
Trypanosoma cruzi trypanothione reductase, putative 0.0192 0.0799 0.6241
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0169 0.0689 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0226 0.0652
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0055 0.0055
Mycobacterium ulcerans phosphoglycerate kinase 0.0165 0.0668 0.223
Brugia malayi follicle stimulating hormone receptor 0.1421 0.6681 0.6681
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0067 0.0198 0.1535
Loa Loa (eye worm) hypothetical protein 0.0169 0.0689 0.0687
Trypanosoma brucei unspecified product 0.009 0.0312 0.2426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0067 0.0198 0.1535
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0119 0.0449 0.0992
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0069 0.0209 0.3008
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0185 0.0199
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0169 0.0689 0.0743
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0118 0.0444 0.1432
Mycobacterium tuberculosis Conserved protein 0.0072 0.0226 0.0652
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0116 0.1434
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0067 0.0198 0.0553
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.1279 1
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0226 0.2805
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0067 0.0198 0.1535
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0124 0.0958
Echinococcus granulosus cpg binding protein 0.0098 0.0349 0.0349
Loa Loa (eye worm) MBCTL1 0.0106 0.0388 0.0386
Brugia malayi mbt repeat family protein 0.0093 0.0326 0.0325
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1421 0.6681 0.6681
Giardia lamblia NADH oxidase lateral transfer candidate 0.0067 0.0198 0.248
Echinococcus granulosus dnaJ subfamily B 0.0866 0.4022 0.4022
Onchocerca volvulus 0.0027 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0237 0.1015 0.1013
Loa Loa (eye worm) hypothetical protein 0.2115 1 1
Schistosoma mansoni inositol monophosphatase 0.0073 0.0229 0.0247
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.062 0.2846 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0106 0.0388 0.0388
Echinococcus granulosus sterol O acyltransferase 1 0.0169 0.0689 0.0689
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0067 0.0198 0.0553
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0185 0.0183
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0116 0.0897
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.0449 0.0992
Echinococcus granulosus intermediate filament protein 0.0027 0.0006 0.0006
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0487 0.2212 0.7737
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0229 0.1777
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0056 0.0121
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0229 0.0503
Mycobacterium tuberculosis Conserved hypothetical protein 0.0071 0.0219 0.0628
Schistosoma mansoni survival motor neuron protein 0.0048 0.0111 0.0119
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0226 0.0652
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.011 0.0406 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0379 0.0837
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0124 0.0124
Mycobacterium ulcerans beta-lactamase 0.0072 0.0226 0.0652
Echinococcus granulosus carbonic anhydrase 0.011 0.0406 0.0406
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0229 0.0503
Trypanosoma brucei unspecified product 0.0049 0.0113 0.0874
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Loa Loa (eye worm) hypothetical protein 0.011 0.0406 0.0404
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0065 0.0192 0.1487
Brugia malayi MBOAT family protein 0.0169 0.0689 0.0687
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0088 0.0301 0.0921
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0169 0.0689 0.0689
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0119 0.0449 0.3502
Toxoplasma gondii exonuclease III APE 0.0037 0.0056 0.0679
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0185 0.0185
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Schistosoma mansoni ap endonuclease 0.0037 0.0056 0.0061
Loa Loa (eye worm) hypothetical protein 0.0072 0.0226 0.0224
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0131 0.0286
Loa Loa (eye worm) hypothetical protein 0.0169 0.0689 0.0687
Schistosoma mansoni sex comb on midleg homolog 0.0093 0.0326 0.0352
Schistosoma mansoni pyruvate kinase 0.0034 0.0043 0.0046
Brugia malayi Inositol-1 0.0073 0.0229 0.0227
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0169 0.0689 0.0689
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0278 0.03
Schistosoma mansoni hypothetical protein 0.0142 0.0559 0.0602
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Entamoeba histolytica hypothetical protein 0.0142 0.0559 0.8105
Echinococcus granulosus carbonic anhydrase II 0.0203 0.0852 0.0852
Schistosoma mansoni caspase-3 (C14 family) 0.0026 0.0002 0.0002
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.0169 0.1307
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0002 0.0001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0002 0.0001
Loa Loa (eye worm) carbonic anhydrase 3 0.0203 0.0852 0.085
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0203 0.0852 0.085
Schistosoma mansoni sex comb on midleg homolog 0.0093 0.0326 0.0352
Leishmania major carbonic anhydrase-like protein 0.0203 0.0852 0.6656
Loa Loa (eye worm) MBOAT family protein 0.0169 0.0689 0.0687
Schistosoma mansoni ap endonuclease 0.0037 0.0056 0.0061
Echinococcus granulosus caspase 8 0.0026 0.0002 0.0002
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0169 0.0689 0.0689
Trypanosoma brucei unspecified product 0.0049 0.0113 0.0874
Trypanosoma brucei phosphoglycerate kinase 0.0165 0.0668 0.5216
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0067 0.0198 0.1535
Schistosoma mansoni alpha-glucosidase 0.0267 0.1157 0.1247
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0119 0.0449 0.0992
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0146 0.058 0.1283
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0071 0.0219 0.0236
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0088 0.0301 0.0921
Brugia malayi hypothetical protein 0.005 0.0116 0.0115
Plasmodium falciparum thioredoxin reductase 0.0067 0.0198 0.2456
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0056 0.0426
Echinococcus granulosus lamin 0.0027 0.0006 0.0006
Schistosoma mansoni carbonic anhydrase-related 0.011 0.0406 0.0437
Loa Loa (eye worm) hypothetical protein 0.0119 0.0447 0.0445
Brugia malayi beta-lactamase family protein 0.0072 0.0226 0.0224
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0226 0.1753
Treponema pallidum NADH oxidase 0.0067 0.0198 0.2238
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0067 0.0198 0.2456
Brugia malayi beta-lactamase family protein 0.0072 0.0226 0.0224
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.0209 0.0459
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0088 0.0301 0.3999
Toxoplasma gondii ABC1 family protein 0.0072 0.0226 0.2805
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0067 0.0198 0.1535
Loa Loa (eye worm) hypothetical protein 0.0169 0.0689 0.0687
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0438 0.1978 0.6901
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0088 0.0301 0.0921
Treponema pallidum phosphoglycerate kinase 0.0165 0.0668 0.9668
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0088 0.0301 0.0921
Echinococcus granulosus neuropeptide s receptor 0.0933 0.4346 0.4346
Brugia malayi glutaminase DH11.1 0.0312 0.1374 0.1373
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0076 0.0581
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0053 0.0131 0.0286
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0056 0.0679
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0088 0.0301 0.0324
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0146 0.058 0.8593
Loa Loa (eye worm) glutaminase 2 0.0312 0.1374 0.1373
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0226 0.0652
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.016 0.016
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0124 0.0958
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0124 0.0124
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0043 0.0091
Plasmodium falciparum thioredoxin reductase 0.0192 0.0799 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0073 0.0226 0.0224
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0043 0.0321
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0471 0.0508
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0173 0.0171
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0053 0.0131 0.0141
Trypanosoma cruzi glycerol uptake protein, putative 0.0169 0.0689 0.5381
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0069 0.0209 0.2591
Brugia malayi beta-lactamase 0.0072 0.0226 0.0224
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.0449 0.3502
Trypanosoma brucei glycerol uptake protein, putative 0.0169 0.0689 0.5381
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.025 0.1939
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0002 0.0001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0463 0.2094 0.7315
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0002 0.0001
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.0449 0.0992
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0088 0.0301 0.0299
Onchocerca volvulus 0.0093 0.0326 0.072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.0444 0.1432
Entamoeba histolytica hypothetical protein 0.0142 0.0559 0.8105
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0002 0.0001
Onchocerca volvulus 0.0027 0.0006 0.001
Entamoeba histolytica hypothetical protein 0.0169 0.0689 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0043 0.0041
Leishmania major glycerol uptake protein, putative 0.0169 0.0689 0.5381
Loa Loa (eye worm) hypothetical protein 0.0169 0.0689 0.0687
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0169 0.0689 0.8621
Loa Loa (eye worm) MBOAT family protein 0.0169 0.0689 0.0687
Echinococcus granulosus zinc finger protein 0.1795 0.8469 0.8469
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0043 0.0321
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.0449 0.0992
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0056 0.0048
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0071 0.0219 0.0217
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0169 0.0689 0.0743
Trypanosoma brucei DNA polymerase eta, putative 0.0096 0.0337 0.2624
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0124 0.0958
Schistosoma mansoni lamin 0.0027 0.0006 0.0007
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0077 0.025 0.1939
Echinococcus granulosus caspase 2 0.0026 0.0002 0.0002
Trypanosoma brucei metacaspase MCA3 0.0026 0.0002 0.0003
Echinococcus multilocularis neutral alpha glucosidase AB 0.0069 0.0209 0.0209
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.0449 0.0992
Leishmania major DNA polymerase eta, putative 0.0096 0.0337 0.2624
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0069 0.0209 0.3008
Brugia malayi Bromodomain containing protein 0.0082 0.0272 0.027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0274 0.1192 0.119
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0203 0.0852 0.085
Onchocerca volvulus 0.0048 0.0111 0.0242
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0124 0.0272
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0542 0.4227
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.062 0.2846 1
Brugia malayi Phosphoglycerate kinase 0.0061 0.0169 0.0167
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0229 0.0229
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0274 0.1192 0.1192
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0043 0.0511
Toxoplasma gondii aldehyde dehydrogenase 0.0118 0.0444 0.5549
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.1279 1
Echinococcus granulosus muscleblind protein 0.2115 1 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0027 0.0009 0.0009
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0169 0.0689 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0146 0.058 0.058
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0376 0.1677 0.1677
Brugia malayi Thioredoxin reductase 0.0192 0.0799 0.0797
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0124 0.0134
Trichomonas vaginalis DNA polymerase eta, putative 0.0097 0.0342 0.0755
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.0103 0.1262
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.2115 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0116 0.1434
Echinococcus multilocularis musashi 0.0027 0.0006 0.0006
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0146 0.058 0.8414
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0229 0.0229
Echinococcus granulosus o acyltransferase membrane bound domain 0.0169 0.0689 0.0689
Trypanosoma cruzi DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Trypanosoma brucei DNA polymerase IV, putative 0.0097 0.0342 0.2665
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0067 0.0198 0.1535
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0689 0.1524
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0315 0.0313
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0226 0.0243
Brugia malayi Hhat protein 0.0169 0.0689 0.0687
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0067 0.0198 0.2456
Mycobacterium tuberculosis Probable dehydrogenase 0.0438 0.1978 0.6901
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0067 0.0198 0.1535
Echinococcus multilocularis polycomb protein SCMH1 0.0093 0.0326 0.0326
Echinococcus granulosus lysosomal alpha glucosidase 0.031 0.1364 0.1364
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.0169 0.1307
Toxoplasma gondii Erv1 / Alr family protein 0.0065 0.0192 0.2379
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0144 0.1114
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0043 0.0091
Schistosoma mansoni phosphoglycerate kinase 0.0165 0.0668 0.072
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0056 0.0792
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0026 0.0024
Loa Loa (eye worm) RNA binding protein 0.0061 0.0173 0.0171
Loa Loa (eye worm) hhat protein 0.0169 0.0689 0.0687
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0169 0.0689 0.0689
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0043 0.0041
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0067 0.0198 0.1535
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0056 0.0214
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0118 0.0444 0.0444
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.0471 0.0471
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0226 0.0497
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.0471 0.5885
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0038 0.0061 0.0064
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0002 0.0001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0438 0.1978 0.6901
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0124 0.0471 0.0508
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0198 0.0826 0.089
Onchocerca volvulus 0.0083 0.0278 0.0613
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0056 0.0054
Trypanosoma cruzi trypanothione reductase, putative 0.0067 0.0198 0.1535
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0226 0.0497
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0009 0.0009
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0124 0.0124
Treponema pallidum alginate O-acetylation protein (algI) 0.0169 0.0689 1
Chlamydia trachomatis phosphoglycerate kinase 0.0165 0.0668 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0093 0.0326 0.0326
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0009 0.001
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0169 0.0689 0.0743
Echinococcus multilocularis pyruvate kinase 0.0034 0.0043 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0108 0.083
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0002 0.0001
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0146 0.058 0.058
Schistosoma mansoni hypothetical protein 0.0066 0.0196 0.0211
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0055 0.0055
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0002 0.0002
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0053 0.0131 0.0129
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0026 0.0026
Loa Loa (eye worm) hhat protein 0.0169 0.0689 0.0687
Plasmodium vivax thioredoxin reductase, putative 0.0192 0.0799 1
Trypanosoma brucei DNA polymerase IV, putative 0.009 0.0312 0.2426
Trichomonas vaginalis porcupine, putative 0.0169 0.0689 0.1524
Plasmodium falciparum glutathione reductase 0.0192 0.0799 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0077 0.025 0.0737
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0185 0.2667
Trypanosoma cruzi glycerol uptake protein, putative 0.0169 0.0689 0.5381
Schistosoma mansoni hypothetical protein 0.0169 0.0689 0.0743
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0226 0.0497
Trypanosoma cruzi metacaspase, putative 0.0026 0.0002 0.0003
Loa Loa (eye worm) glutathione reductase 0.0192 0.0799 0.0797
Loa Loa (eye worm) hypothetical protein 0.0093 0.0326 0.0325
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0185 0.1435
Loa Loa (eye worm) mbt repeat family protein 0.0093 0.0326 0.0325
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0203 0.0852 0.085
Onchocerca volvulus 0.0091 0.0315 0.0695
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0449 0.0992
Brugia malayi PHD-finger family protein 0.0031 0.0026 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0449 0.0992
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0043 0.0041
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0124 0.0958
Toxoplasma gondii thioredoxin reductase 0.0192 0.0799 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0342 0.034
Mycobacterium ulcerans L-lysine aminotransferase 0.0088 0.0301 0.0921
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0088 0.0301 0.0921
Brugia malayi ImpB/MucB/SamB family protein 0.0096 0.0337 0.0335
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0043 0.0091
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0169 0.1307
Plasmodium falciparum carbonic anhydrase 0.011 0.0406 0.5068
Echinococcus multilocularis neuropeptide receptor A26 0.0933 0.4346 0.4346
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.0444 0.1432
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0169 0.0689 0.0743
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0067 0.0198 0.0198
Echinococcus granulosus neutral alpha glucosidase AB 0.0069 0.0209 0.0209
Echinococcus granulosus caspase 0.0026 0.0002 0.0002
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0169 0.1307
Brugia malayi Phosphoglycerate kinase 0.0165 0.0668 0.0666
Brugia malayi Pre-SET motif family protein 0.0851 0.395 0.3948
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0076 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0061 0.0131
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0131 0.0286
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0097 0.0342 0.0755
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0209 0.1619
Echinococcus granulosus Aminotransferase class III 0.0088 0.0301 0.0301
Echinococcus multilocularis cpg binding protein 0.0098 0.0349 0.0349
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0146 0.058 0.058
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0487 0.2212 0.7737
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0065 0.0192 0.1487
Entamoeba histolytica hypothetical protein, conserved 0.0169 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0196 0.0194
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0165 0.0668 0.1478
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0049 0.0113 0.0111
Echinococcus granulosus o acyltransferase membrane bound domain 0.0169 0.0689 0.0689
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0146 0.058 0.0625
Echinococcus multilocularis lysosomal alpha glucosidase 0.031 0.1364 0.1364
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0342 0.034
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0146 0.058 0.1283
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0002 0.0003
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0169 0.0689 0.0743
Schistosoma mansoni cpg binding protein 0.0098 0.0349 0.0377
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0067 0.0198 0.1535
Brugia malayi hypothetical protein 0.0142 0.0559 0.0557
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0069 0.0209 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0144 0.1114
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1015 0.1015
Brugia malayi MBOAT family protein 0.0169 0.0689 0.0687
Loa Loa (eye worm) hypothetical protein 0.0119 0.0447 0.0445
Onchocerca volvulus 0.0968 0.4511 1
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0226 0.0652
Echinococcus multilocularis lamin dm0 0.0027 0.0006 0.0006
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0226 0.0226
Brugia malayi MBOAT family protein 0.1964 0.9279 0.9279
Mycobacterium ulcerans hypothetical protein 0.0154 0.0617 0.2047
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0002 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0119 0.0449 0.3502
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0106 0.0388 0.0386
Brugia malayi diacylglycerol acyltransferase 0.0169 0.0689 0.0687
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0056 0.0054
Echinococcus granulosus lamin dm0 0.0027 0.0006 0.0006
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0093 0.0326 0.0352
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0169 0.0689 0.8621
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0165 0.0668 0.5216
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0081 0.0267 0.0589
Brugia malayi polk-prov protein 0.0048 0.0108 0.0106
Echinococcus multilocularis pyruvate kinase 0.0034 0.0043 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0116 0.0897
Leishmania major pyruvate kinase 0.0034 0.0043 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0002 0.0001
Echinococcus multilocularis ubiquitin specific protease 41 0.0146 0.058 0.058
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0118 0.0444 0.3464
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0229 0.1777
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.3092 0.3332
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0006 0.0005
Echinococcus multilocularis carbonic anhydrase II 0.0203 0.0852 0.0852
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.0209 0.0459
Loa Loa (eye worm) runx1 0.0054 0.0137 0.0135
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0119 0.0918
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0169 0.0689 0.0687
Echinococcus granulosus ubiquitin specific protease 41 0.0146 0.058 0.058
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0119 0.0449 0.0992
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0093 0.0326 0.072
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0067 0.0198 0.2456
Loa Loa (eye worm) hypothetical protein 0.0072 0.0226 0.0224
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0069 0.0209 0.0459
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0088 0.0301 0.0921
Trypanosoma cruzi metacaspase, putative 0.0026 0.0002 0.0003
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0229 0.0663
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.0035 0.0035
Leishmania major trypanothione reductase 0.0192 0.0799 0.6241
Schistosoma mansoni carbonic anhydrase-related 0.011 0.0406 0.0437
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0124 0.0272
Onchocerca volvulus Huntingtin homolog 0.0119 0.0447 0.0987
Onchocerca volvulus 0.0124 0.0471 0.1041
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0124 0.0272
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0081 0.0267 0.208
Echinococcus granulosus microtubule associated protein 2 0.0671 0.3092 0.3092
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0226 0.0224
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.016 0.016
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0071 0.0219 0.0219
Schistosoma mansoni phosphoglycerate kinase 0.0165 0.0668 0.072
Brugia malayi hypothetical protein 0.0119 0.0447 0.0445
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0146 0.058 0.4527
Loa Loa (eye worm) hypothetical protein 0.0072 0.0226 0.0224
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0169 0.0689 0.8621
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0043 0.0041
Trichomonas vaginalis glutaminase, putative 0.0312 0.1374 0.3044
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.011 0.0406 0.0404
Brugia malayi intermediate filament protein 0.0027 0.0006 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0438 0.1978 0.6901
Onchocerca volvulus 0.0429 0.1933 0.4282
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.1279 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0124 0.0124
Schistosoma mansoni alpha glucosidase 0.0069 0.0209 0.0225
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0028 0.0015 0.0163
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.031 0.1364 0.1362
Echinococcus multilocularis Aminotransferase class III 0.0088 0.0301 0.0301
Plasmodium falciparum GAF domain-related protein, putative 0.0038 0.0061 0.0735
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0067 0.0198 0.2456
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0542 0.4227
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0203 0.0852 0.0918
Loa Loa (eye worm) thioredoxin reductase 0.0192 0.0799 0.0797
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.011 0.0406 0.0404
Brugia malayi glutathione reductase 0.0192 0.0799 0.0797
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0169 0.0689 0.0689
Trypanosoma cruzi DNA polymerase kappa, putative 0.0097 0.0342 0.2665
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.0449 0.3502
Brugia malayi Bromodomain containing protein 0.0039 0.0067 0.0065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0274 0.1192 0.1192
Echinococcus multilocularis ornithine aminotransferase 0.0088 0.0301 0.0301
Echinococcus multilocularis muscleblind protein 1 0.2115 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0196 0.0194
Brugia malayi hypothetical protein 0.0237 0.1015 0.1013
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0203 0.0852 0.0918
Schistosoma mansoni hypothetical protein 0.0031 0.0026 0.0028
Mycobacterium tuberculosis Probable aminotransferase 0.062 0.2846 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0274 0.1192 0.1285
Schistosoma mansoni hypothetical protein 0.011 0.0406 0.0437
Schistosoma mansoni hypothetical protein 0.0346 0.1536 0.1656
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0146 0.058 0.4527
Onchocerca volvulus 0.0072 0.0226 0.0497
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0088 0.0301 0.0921
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0169 0.0689 1
Trypanosoma brucei glucosidase, putative 0.0069 0.0209 0.1619
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0165 0.0668 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0617 0.2047
Echinococcus granulosus histone lysine methyltransferase setb 0.0141 0.0555 0.0555
Mycobacterium ulcerans DNA polymerase IV 0.0097 0.0342 0.1068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0067 0.0198 0.1535
Echinococcus granulosus carbonic anhydrase 0.011 0.0406 0.0406
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0278 0.0278
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0119 0.0449 0.0992
Brugia malayi TAR-binding protein 0.0061 0.0173 0.0171
Leishmania major alpha glucosidase II subunit, putative 0.0069 0.0209 0.1619
Plasmodium falciparum ornithine aminotransferase 0.0088 0.0301 0.3749
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0379 0.0837
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0226 0.0497
Entamoeba histolytica hypothetical protein 0.0142 0.0559 0.8105
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.0444 0.0479

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.114 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.112 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.063 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.019 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.888 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.869 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.696 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.612 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
MIC (functional) = 5.2 ug ml-1 Antibacterial activity against Mycobacterium tuberculosis T1538 under aerobic condition after 7 days by MTT assay ChEMBL. 25934225

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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