Detailed information for compound 558098

Basic information

Technical information
  • TDR Targets ID: 558098
  • Name: (4-Hydroxy-3-methoxyphenyl)acetic acid
  • MW: 182.173 | Formula: C9H10O4
  • H donors: 2 H acceptors: 3 LogP: 1 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1O)CC(=O)O
  • InChi: 1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12)
  • InChiKey: QRMZSPFSDQBLIX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(4-hydroxy-3-methoxy-phenyl)acetic acid
  • 2-(4-hydroxy-3-methoxyphenyl)acetic acid
  • 2-(4-hydroxy-3-methoxy-phenyl)ethanoic acid
  • 3-Methoxy-4-hydroxyphenylacetic acid
  • 3-Methoxy-4-hydroxyphenylacetate
  • 306-08-1
  • 4-Hydroxy-3-methoxybenzeneacetic acid
  • 4-Hydroxy-3-methoxyphenylacetic acid
  • Acetic acid, (4-hydroxy-3-methoxyphenyl)-
  • Acetic acid, (4-hydroxy-3-methoxyphenyl)- (8CI)
  • Benzeneacetic acid, 4-hydroxy-3-methoxy-
  • C05582
  • C06045
  • EINECS 206-176-7
  • EU-0100632
  • H1252_SIGMA
  • Hempa
  • homovanillic acid
  • Homovanillate
  • HVA
  • Lopac-H-1252
  • Lopac0_000632
  • MLS001056771
  • NCGC00015497-01
  • NCGC00093999-03
  • NSC 16682
  • NSC16682
  • Oprea1_505423
  • SMR000326729
  • ST5331815
  • Vanillacetic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arylsulfatase A Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Rattus norvegicus Muscarinic acetylcholine receptor M1 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130847 All targets in OG5_130847
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Loa Loa (eye worm) hypothetical protein Muscarinic acetylcholine receptor M1   460 aa 425 aa 22.1 %
Echinococcus multilocularis serotonin receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Muscarinic acetylcholine receptor M1   460 aa 462 aa 23.4 %
Schistosoma mansoni amine GPCR Muscarinic acetylcholine receptor M1   460 aa 463 aa 27.0 %
Echinococcus granulosus biogenic amine 5HT receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Mycobacterium ulcerans arylsulfatase AtsD arylsulfatase A 509 aa 439 aa 25.1 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase 0.0073 0.0092 0.0817
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018 0.0003 0.0003
Toxoplasma gondii leucyl aminopeptidase LAP 0.0105 0.0144 0.4362
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0081 0.0717
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0057 0.1253
Loa Loa (eye worm) hypothetical protein 0.0148 0.0214 0.1895
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0303
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0005 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.009 0.009
Brugia malayi ecdysone receptor 0.0034 0.0029 0.0254
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0020857 0.5 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0039 0.0037 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.009 0.0793
Brugia malayi nuclear hormone receptor 0.0020857 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.0092 0.0817
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0018 0.0003 0.0033
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0002 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0045 0.0996
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0092 0.2791
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0092 0.1246
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0187 0.3662
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0018 0.0003 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0001 0.0012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0142 0.0205 1
Schistosoma mansoni thyroid hormone receptor 0.0071 0.009 0.009
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0187 0.9133
Echinococcus multilocularis expressed protein 0.0018 0.0003 0.0003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0033 0.0033
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0022 0.0197
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018 0.0003 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0409 0.0638 0.0638
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0032 0.0965
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0028 0.0615
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0056 0.0056
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0018 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0088 0.1967
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0117
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0018 0.0003 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0092 0.2065
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0018 0.0003 0.0003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0092 0.2056
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0019 0.0004 0.0136
Brugia malayi MAP kinase sur-1 0.005 0.0056 0.0496
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0071 0.009 0.0793
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0020857 0.5 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0020857 0.5 0.5
Brugia malayi nuclear receptor NHR-67 0.0034 0.0029 0.0254
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0041 0.0901
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0071 0.0071
Schistosoma mansoni nuclear receptor 0.0034 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0071 0.009 0.0793
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0003 0.0025
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0111 0.2481
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0092 0.1801
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0018 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0013 0.0388
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0104 0.5025
Loa Loa (eye worm) hypothetical protein 0.0179 0.0264 0.2338
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0025
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0008 0.0159
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0018 0.0003 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0029 0.0254
Echinococcus granulosus leucine aminopeptidase protein 0.0105 0.0144 0.0144
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0013 0.0388
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0195 0.0195
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0092 0.2065
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0045 0.0047 0.0047
Echinococcus granulosus dnaJ subfamily B 0.1612 0.2586 0.2586
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0008 0.0159
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0056 0.1098
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0071 0.009 0.0793
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0111 0.098
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0005 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0022 0.0474
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0022 0.0436
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0071 0.009 0.009
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0056 0.1242
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.001 0.001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0286 0.0438 0.3881
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0088 0.1967
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0187 0.4215
Brugia malayi RNA binding protein 0.0133 0.0189 0.1674
Trichomonas vaginalis set domain proteins, putative 0.0289 0.0442 1
Echinococcus granulosus Ankyrin 0.0018 0.0003 0.0003
Brugia malayi Probable ClpP-like protease 0.0094 0.0127 0.1128
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0039 0.0037 0.1116
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0049 0.0049
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0018 0.0003 0.0003
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0022 0.0194
Brugia malayi Death domain containing protein 0.0017 0.0002 0.0022
Brugia malayi jmjC domain containing protein 0.0059 0.0071 0.0624
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0104 0.0104
Echinococcus multilocularis survival motor neuron protein 1 0.0713 0.113 0.113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0020857 0.5 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0081 0.1799
Trichomonas vaginalis helicase, putative 0.0026 0.0016 0.033
Brugia malayi nuclear hormone receptor 0.0071 0.009 0.0793
Toxoplasma gondii hypothetical protein 0.0033 0.0027 0.0822
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0020857 0.5 0.5
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0013 0.0117
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0022 0.0436
Plasmodium falciparum M17 leucyl aminopeptidase 0.0105 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0020857 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.003
Brugia malayi cytosol aminopeptidase 0.0021 0.0008 0.0072
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.0003 0.0003
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0104 0.0104
Plasmodium vivax ataxin-2 like protein, putative 0.0099 0.0135 0.9417
Brugia malayi ecdysteroid receptor 0.0071 0.009 0.0793
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0187 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0020857 0.5 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0071 0.009 0.0793
Onchocerca volvulus Huntingtin homolog 0.0249 0.0378 0.8545
Echinococcus granulosus FTZ F1 alpha 0.0020857 0.5 0.5
Echinococcus multilocularis muscleblind protein 0.0148 0.0214 0.0214
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0092 0.1246
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0005 0.0089
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0008 0.0159
Loa Loa (eye worm) beta-lactamase 0.0073 0.0092 0.0817
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0038 0.0035 0.0312
Echinococcus granulosus dna polymerase eta 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0025
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0001 0.0012
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.0257 0.3512
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.003
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0029 0.0254
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0018 0.0003 0.0025
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.0118 0.0118
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0092 0.1246
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0013 0.0157
Trypanosoma brucei protein kinase, putative 0.005 0.0056 0.1098
Onchocerca volvulus Bile acid receptor homolog 0.0071 0.009 0.1981
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0032 0.2213
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.0045 0.2157
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0020857 0.5 0.5
Loa Loa (eye worm) acetyltransferase 0.014 0.0201 0.1781
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0092 0.1808
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0127 0.6838
Brugia malayi Steroid receptor seven-up type 2 0.0020857 0.5 0.5
Loa Loa (eye worm) TAR-binding protein 0.0133 0.0189 0.1674
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0005 0.004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0031 0.0031
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0018 0.0003 0.0003
Echinococcus granulosus tar DNA binding protein 0.0133 0.0189 0.0189
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0105 0.0144 0.7509
Schistosoma mansoni nuclear hormone receptor 0.0071 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0003 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0032 0.0691
Schistosoma mansoni cpg binding protein 0.012 0.0168 0.0168
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0081 0.1799
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0127 0.489
Schistosoma mansoni hypothetical protein 0.0142 0.0205 0.0205
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0025
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0022 0.0022
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.0228 0.4468
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0187 0.3662
Loa Loa (eye worm) CXXC zinc finger family protein 0.0113 0.0158 0.1396
Schistosoma mansoni lamin 0.0055 0.0063 0.0063
Echinococcus granulosus intermediate filament protein 0.0055 0.0063 0.0063
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0055 0.0063 0.056
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0056 0.1098
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0020857 0.5 0.5
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0092 0.0092
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0187 0.7244
Giardia lamblia GTOR 0.0088 0.0117 1
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0081 0.0718
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0071 0.009 0.0793
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0032 0.0965
Echinococcus granulosus chromobox protein 1 0.0084 0.0111 0.0111
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.008 0.1071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0071 0.009 0.0793
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0071 0.0071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0024 0.0024
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0013 0.0388
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0036 0.1679
Brugia malayi nuclear receptor RXR 0.0034 0.0029 0.0254
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.002 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0081 0.1799
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0013 0.0388
Loa Loa (eye worm) hypothetical protein 0.0096 0.0131 0.1156
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0016 0.033
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0029 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0035 0.0312
Echinococcus granulosus lamin dm0 0.0055 0.0063 0.0063
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0032 0.0296
Schistosoma mansoni netrin receptor unc5 0.0017 0.0002 0.0002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0071 0.009 0.009
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0045 0.0996
Brugia malayi hypothetical protein 0.0099 0.0135 0.1198
Echinococcus granulosus cpg binding protein 0.012 0.0168 0.0168
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0002 0.0022
Brugia malayi Pre-SET motif family protein 0.0039 0.0037 0.0325
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0071 0.009 0.009
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0331 0.0511 1
Mycobacterium leprae Probable lipase LipE 0.0073 0.0092 0.4551
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0088 0.0117 0.2296
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0005 0.0107
Loa Loa (eye worm) hypothetical protein 0.0054 0.0062 0.0545
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0073 0.0092 0.0817
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0029 0.0254
Schistosoma mansoni cpg binding protein 0.0113 0.0158 0.0158
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0088 0.0117 0.0117
Onchocerca volvulus 0.0034 0.0029 0.0596
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0075 0.1003
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0013 0.0117
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0045 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0142 0.0205 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0041 0.2857
Loa Loa (eye worm) hypothetical protein 0.0099 0.0135 0.1198
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.008 0.382
Loa Loa (eye worm) hypothetical protein 0.0249 0.0378 0.3347
Schistosoma mansoni nuclear hormone receptor 0.0020857 0.5 0.5
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018 0.0003 0.0003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0071 0.009 0.009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0020857 0.5 0.5
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0032 0.2418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0051 0.1136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0013 0.0388
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0201 0.0201
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0187 0.9133
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0017 0.0001 0.0001
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0008 0.0159
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0187 0.3662
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0465 0.0728 1
Loa Loa (eye worm) RNA binding protein 0.0133 0.0189 0.1674
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0013 0.0157
Schistosoma mansoni lamin 0.0055 0.0063 0.0063
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0045 0.0886
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0008 0.0159
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0020857 0.5 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Echinococcus multilocularis ecdysone induced protein 78C 0.0020857 0.5 0.5
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0018 0.0003 0.0003
Brugia malayi hypothetical protein 0.0038 0.0035 0.0312
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0088 0.0117 0.2296
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0071 0.009 0.009
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0029 0.0254
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0025
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0018 0.0003 0.0003
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0029 0.0254
Mycobacterium ulcerans lipase LipD 0.0073 0.0092 0.3509
Toxoplasma gondii ABC1 family protein 0.0073 0.0092 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0117 0.2631
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0127 0.8861
Onchocerca volvulus 0.0024 0.0013 0.0245
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0005 0.0107
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0013 0.0117
Loa Loa (eye worm) hypothetical protein 0.0020857 0.5 0.5
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0003 0.0003
Brugia malayi Cytochrome P450 family protein 0.0019 0.0005 0.0048
Loa Loa (eye worm) DR-78 0.0034 0.0029 0.0254
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0022 0.0022
Loa Loa (eye worm) inositol-1 0.0073 0.0092 0.0814
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0034 0.066
Leishmania major DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0045 0.0045
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0029 0.0254
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0020857 0.5 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0041 0.0901
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0142 0.0205 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0051 0.1136
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0045 0.0996
Brugia malayi hypothetical protein 0.0147 0.0213 0.1881
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0088 0.0117 0.2296
Echinococcus multilocularis lamin dm0 0.0055 0.0063 0.0063
Entamoeba histolytica G protein alpha subunit, putative 0.0018 0.0003 0.0072
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0052 0.1138
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0075 0.1003
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0056 0.1098
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0142 0.0205 0.0205
Leishmania major hypothetical protein, conserved 0.0073 0.0092 0.1808
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0049 0.0049
Echinococcus multilocularis cpg binding protein 0.012 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Brugia malayi nuclear receptor NHR-88 0.0034 0.0029 0.0254
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0127 0.0127
Echinococcus granulosus geminin 0.0671 0.1061 0.1061
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0032 0.2024
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0105 0.0144 0.1954
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0036 0.2471
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0018 0.0003 0.0025
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018 0.0003 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0003 0.0003
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0105 0.0144 0.2814
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0104 0.0916
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0013 0.0388
Loa Loa (eye worm) hypothetical protein 0.0071 0.009 0.0793
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0071 0.009 0.1981
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0018 0.0003 0.0033
Brugia malayi photoreceptor-specific nuclear receptor 0.0020857 0.5 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0071 0.009 0.1981
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0187 0.9133
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0008 0.0159
Loa Loa (eye worm) steroid hormone receptor 0.0071 0.009 0.0793
Schistosoma mansoni coup transcription factor 0.0020857 0.5 0.5
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0092 0.4456
Loa Loa (eye worm) hypothetical protein 0.0071 0.009 0.0793
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0021 0.0008 0.0072
Echinococcus multilocularis tar DNA binding protein 0.0133 0.0189 0.0189
Onchocerca volvulus 0.0055 0.0063 0.1382
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0016 0.033
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0056 0.1242
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0041 0.0041
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0022 0.0197
Loa Loa (eye worm) hypothetical protein 0.0020857 0.5 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0071 0.009 0.009
Brugia malayi beta-lactamase family protein 0.0073 0.0092 0.0817
Mycobacterium ulcerans hypothetical protein 0.0174 0.0257 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0032 0.2024
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0018 0.0003 0.0003
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0005 0.0005
Toxoplasma gondii target of rapamycin (TOR), putative 0.0066 0.0081 0.2447
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0051 0.1121
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0088 0.0117 0.57
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0035 0.0312
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0153
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0038 0.0035 0.0312
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0032 0.0691
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.0045 0.0886
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0052 0.1138
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.009 0.0793
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0073 0.0092 0.0817
Brugia malayi nuclear receptor RXR 0.0038 0.0035 0.0312
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0092 0.1246
Schistosoma mansoni chromobox protein 0.0084 0.0111 0.0111
Brugia malayi chromobox protein homolog 3 0.0047 0.0051 0.0449
Brugia malayi hypothetical protein 0.0034 0.0029 0.0254
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0092 0.3509
Loa Loa (eye worm) hypothetical protein 0.0047 0.0051 0.0449
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0020857 0.5 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0038 0.0836
Echinococcus multilocularis Ankyrin 0.0018 0.0003 0.0003
Schistosoma mansoni steroid hormone receptor ad4bp 0.0071 0.009 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0029 0.0029
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0075 0.3533
Loa Loa (eye worm) hypothetical protein 0.0249 0.0378 0.3347
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0005 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0020857 0.5 0.5
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0201 0.1781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0117 0.2631
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0052 0.1138
Echinococcus multilocularis microtubule associated protein 2 0.6187 1 1
Brugia malayi intermediate filament protein 0.0055 0.0063 0.056
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0021 0.0008 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0020857 0.5 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0099 0.0135 0.9417
Brugia malayi 6-phosphofructokinase 0.0131 0.0187 0.1656
Echinococcus granulosus death domain containing protein 0.0017 0.0002 0.0002
Echinococcus multilocularis ecdysone induced protein 78C 0.0071 0.009 0.009
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0056 0.1242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0013 0.0257
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0214 0.0214
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0017 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.009 0.0793
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0005 0.0038
Echinococcus multilocularis dnaJ subfamily B 0.1612 0.2586 0.2586
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Brugia malayi photoreceptor-specific nuclear receptor 0.0071 0.009 0.0793
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0038 0.0836
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0056 0.1098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.0117 0.1038
Schistosoma mansoni hypothetical protein 0.1612 0.2586 0.2586
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0018 0.0003 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0032 0.0691
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0024 0.021
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0013 0.0259
Toxoplasma gondii hypothetical protein 0.0053 0.0061 0.1847
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0092 0.1801
Echinococcus granulosus expressed protein 0.0018 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0094 0.0127 0.1128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0059 0.1306
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0020857 0.5 0.5
Brugia malayi N-terminal motif family protein 0.0179 0.0264 0.2338
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.005 0.0975
Onchocerca volvulus 0.0020857 0.5 0.5
Echinococcus granulosus dna polymerase kappa 0.0019 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.006 0.1325
Schistosoma mansoni retinoic acid receptor RXR 0.0071 0.009 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0016 0.033
Onchocerca volvulus 0.0113 0.0158 0.3532
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.007 0.0088 0.1726
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0713 0.113 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0039 0.0037 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0020857 0.5 0.5
Echinococcus multilocularis serine protein kinase ATM 0.0017 0.0001 0.0001
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0187 0.1656
Echinococcus multilocularis FTZ F1 alpha 0.0071 0.009 0.009
Brugia malayi hypothetical protein 0.0713 0.113 1
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0033 0.0294
Brugia malayi hypothetical protein 0.0249 0.0378 0.3347
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0029 0.0029
Loa Loa (eye worm) G protein alpha subunit 3 0.0018 0.0003 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.007 0.1563
Echinococcus multilocularis FTZ F1 alpha 0.0020857 0.5 0.5
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0020857 0.5 0.5
Brugia malayi follicle stimulating hormone receptor 0.0286 0.0438 0.3881
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0056 0.4571
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0016 0.033
Echinococcus granulosus GPCR family 2 0.0031 0.0024 0.0024
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0056 0.1098
Schistosoma mansoni hypothetical protein 0.0671 0.1061 0.1061
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0127 0.8833
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0092 0.2065
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0187 0.1656
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0032 0.0691
Echinococcus multilocularis thyroid hormone receptor alpha 0.0071 0.009 0.009
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0071 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0187 0.4215
Brugia malayi SET domain containing protein 0.0018 0.0003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0035 0.0312
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0092 0.1246
Loa Loa (eye worm) hypothetical protein 0.0071 0.009 0.0793
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0022 0.0474
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0117
Loa Loa (eye worm) hypothetical protein 0.0071 0.009 0.0793
Leishmania major DNA polymerase eta, putative 0.0019 0.0005 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0020857 0.5 0.5
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0056 0.0056
Trypanosoma brucei target of rapamycin kinase 3, putative 0.007 0.0088 0.1726
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0020857 0.5 0.5
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0088 0.0117 0.2296
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0021 0.0008 0.0008
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.0042 0.0821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.006 0.1325
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0036 0.2747
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0029 0.0254
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0020857 0.5 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0071 0.009 0.0793
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0066 0.0081 0.0718
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0022 0.0436
Schistosoma mansoni thyroid hormone receptor 0.0020857 0.5 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0020857 0.5 0.5
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0018 0.0003 0.0033
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0081 0.0081
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0018 0.0003 0.0025
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0029 0.0029
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0032 0.2213
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0045 0.0047 0.0047
Brugia malayi beta-lactamase family protein 0.0073 0.0092 0.0817
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0117
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0056 0.0056
Plasmodium falciparum ataxin-2 like protein, putative 0.0099 0.0135 0.9417
Schistosoma mansoni thyroid hormone receptor 0.0020857 0.5 0.5
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0032 0.2213
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0013 0.0388
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0029 0.0029
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0056 0.1098
Schistosoma mansoni microtubule-associated protein tau 0.6187 1 1
Trypanosoma brucei aminopeptidase, putative 0.0021 0.0008 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0022 0.0474
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0104 0.2027
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0020857 0.5 0.5
Brugia malayi nuclear receptor NHR-88 0.0020857 0.5 0.5
Onchocerca volvulus 0.0018 0.0003 0.0008
Schistosoma mansoni intermediate filament proteins 0.0055 0.0063 0.0063
Brugia malayi ecdysteroid receptor 0.0020857 0.5 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0409 0.0638 0.0638
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0032 0.0691
Schistosoma mansoni inositol monophosphatase 0.0073 0.0092 0.0092
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0088 0.0117 0.2296
Brugia malayi Inositol-1 0.0073 0.0092 0.0814
Brugia malayi Uncoordinated protein 44 0.0017 0.0002 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0028 0.0615
Loa Loa (eye worm) hypothetical protein 0.0071 0.009 0.0793
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0092 0.1801
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0013 0.0259
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0092 0.1808
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0409 0.0638 0.5643
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0020857 0.5 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0013 0.0259
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0056 0.1702
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0187 0.4215
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0187 0.4215
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0088 0.1967
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.021
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.0001 0.0027
Schistosoma mansoni hypothetical protein 0.0145 0.021 0.021
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0092 0.1246
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0071 0.009 0.009
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0022 0.0436
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0187 0.0187
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.0189 0.1674
Schistosoma mansoni hypothetical protein 0.0031 0.0024 0.0024
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0092 0.1246
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.005 0.0975
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0038 0.0836
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0088 0.1967
Onchocerca volvulus 0.0018 0.0003 0.0008
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0071 0.009 0.0793
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0189 0.0189
Trypanosoma cruzi PAB1-binding protein , putative 0.0099 0.0135 0.265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0081 0.1799
Schistosoma mansoni RAR-like nuclear receptor 0.0020857 0.5 0.5
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0057 0.123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0020857 0.5 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0035 0.0035
Mycobacterium ulcerans beta-lactamase 0.0073 0.0092 0.3509
Leishmania major mitochondrial DNA polymerase beta 0.0331 0.0511 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0071 0.009 0.009
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0104 0.2027
Echinococcus granulosus serine protein kinase ATM 0.0017 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0071 0.009 0.0793
Echinococcus multilocularis lamin 0.0055 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.003
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0063 0.056
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.003
Brugia malayi Pre-SET motif family protein 0.0254 0.0386 0.3413
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0092 0.2056
Brugia malayi 6-phosphofructokinase 0.0131 0.0187 0.1656
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0063 0.056
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0016 0.033
Leishmania major cytochrome p450-like protein 0.0019 0.0005 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0020857 0.5 0.5
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.0187 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0039 0.0037 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.005 0.0975
Onchocerca volvulus 0.0073 0.0092 0.2044
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Toxoplasma gondii histone lysine methyltransferase SET1 0.0219 0.033 1
Mycobacterium ulcerans leucyl aminopeptidase 0.0105 0.0144 0.5536
Loa Loa (eye worm) hypothetical protein 0.0148 0.0214 0.1895
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.009 0.009
Onchocerca volvulus Bile acid receptor homolog 0.0020857 0.5 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0051 0.1136
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.004
Brugia malayi Nuclear hormone receptor-like 1 0.0020857 0.5 0.5
Onchocerca volvulus 0.0145 0.021 0.472
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0003 0.0237
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0018 0.0003 0.0003
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0228 0.4468
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0071 0.009 0.0793
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0127 0.489
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0020857 0.5 0.5
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0037 0.0037
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0005 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.009 0.0793
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0018 0.0003 0.0025
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0187 0.1656
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0024 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0059 0.1306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0067 0.1493
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0018 0.0003 0.0003
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0051 0.1098
Brugia malayi hypothetical protein 0.0034 0.0029 0.0254
Chlamydia trachomatis cytosol aminopeptidase 0.0105 0.0144 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0105 0.0144 0.2814
Onchocerca volvulus 0.0034 0.0029 0.0596
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0041 0.1246
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0029 0.0029
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.0045 0.0045
Trypanosoma cruzi PAB1-binding protein , putative 0.0099 0.0135 0.265
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.0118 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0409 0.0638 0.0638
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0020857 0.5 0.5
Brugia malayi TAR-binding protein 0.0133 0.0189 0.1674
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0228 0.4468
Schistosoma mansoni thyroid hormone receptor 0.0071 0.009 0.009
Onchocerca volvulus 0.0073 0.0092 0.2044
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0041 0.1246
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0105 0.0144 0.2814
Onchocerca volvulus 0.0073 0.0092 0.2044
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0005 0.0089
Loa Loa (eye worm) hypothetical protein 0.0073 0.0092 0.0817
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.009 0.0793
Echinococcus granulosus muscleblind protein 0.0148 0.0214 0.0214
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0017 0.0017
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.006 0.1325
Brugia malayi steroid hormone receptor 0.0020857 0.5 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0024 0.0024
Onchocerca volvulus 0.0071 0.009 0.1981
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0071 0.009 0.0793
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0020857 0.5 0.5
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0032 0.2213
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0138
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0005 0.0156
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0020857 0.5 0.5
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0005 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0020857 0.5 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0071 0.009 0.009
Brugia malayi hypothetical protein 0.0018 0.0003 0.0025
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0005 0.0089
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0056 0.0496
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.0035 0.0035
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0020857 0.5 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0005 0.0048
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0029 0.0029
Brugia malayi nuclear receptor NHR-88 0.0071 0.009 0.0793
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0071 0.009 0.009
Loa Loa (eye worm) CHromoDomain protein family member 0.002 0.0007 0.0063
Brugia malayi hypothetical protein 0.0142 0.0205 0.1812
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0018 0.0003 0.0033
Brugia malayi tailless protein 0.0034 0.0029 0.0254
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Brugia malayi conserved hypotetical protein 0.0034 0.0029 0.0254
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0020857 0.5 0.5
Onchocerca volvulus 0.0018 0.0003 0.0008
Echinococcus multilocularis dna polymerase eta 0.0019 0.0005 0.0005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0005 0.0038
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0187 0.0187
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0022 0.0022
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0008 0.0008
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0029 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0020857 0.5 0.5
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0003 0.0033
Mycobacterium tuberculosis Conserved protein 0.0073 0.0092 0.1246
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0017 0.0001 0.0027
Brugia malayi Cytochrome P450 family protein 0.0019 0.0005 0.0048
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0027 0.1883
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0409 0.0638 0.0638
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0029 0.0029
Echinococcus multilocularis chromobox protein 1 0.0084 0.0111 0.0111
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0005 0.0089
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.0511 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0027 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0020857 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.0092 0.0817
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0021 0.0008 0.0008
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0018 0.0003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0071 0.009 0.0793
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0045 0.04
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0018 0.0003 0.0025
Brugia malayi Calcitonin receptor-like protein seb-1 0.0096 0.0131 0.1156
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.0018 0.0003 0.0029
Brugia malayi phosphofructokinase 0.0131 0.0187 0.1656
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0022 0.0436
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0029 0.0596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0409 0.0638 0.0638
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0029 0.0254
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0092 0.2056
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0127 0.6567
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0016 0.033
Loa Loa (eye worm) steroid hormone receptor 0.0020857 0.5 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0063 0.056
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.0045 0.0045
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0017 0.0001 0.0027
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0017 0.0017
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0127 0.8861
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0020857 0.5 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.009 0.009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0020857 0.5 0.5
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0071 0.009 0.0793
Schistosoma mansoni hypothetical protein 0.0066 0.0081 0.0081
Schistosoma mansoni zinc finger protein 0.0034 0.0029 0.0029
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0096 0.0131 0.1156
Schistosoma mansoni hypothetical protein 0.0031 0.0024 0.0024
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0032 0.0965
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0020857 0.5 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0038 0.0836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0071 0.009 0.0793
Schistosoma mansoni transcription factor LCR-F1 0.0142 0.0205 0.0205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0671 0.1061 0.1061
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0008 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0020857 0.5 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.0511 1
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0035 0.0312
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0052 0.0059 0.0059
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0005 0.0081
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0024 0.0024
Onchocerca volvulus Protein ultraspiracle homolog 0.0020857 0.5 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.0099 0.0135 0.4108
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0013 0.0583
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0022 0.0194
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0029 0.0029
Schistosoma mansoni leucine aminopeptidase 0.0021 0.0008 0.0008
Trypanosoma brucei PAB1-binding protein , putative 0.0099 0.0135 0.265
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0008 0.0008
Brugia malayi G-protein alpha subunit 0.0018 0.0003 0.0025
Onchocerca volvulus 0.0289 0.0442 1
Schistosoma mansoni cpg binding protein 0.012 0.0168 0.0168
Echinococcus multilocularis leucine aminopeptidase protein 0.0105 0.0144 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0051 0.1121
Brugia malayi Heterochromatin protein 1 0.0084 0.0111 0.098
Schistosoma mansoni nuclear receptor 0.0034 0.0029 0.0029
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0127 0.627
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0022 0.0022
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0032 0.1497
Plasmodium vivax SET domain protein, putative 0.0039 0.0037 0.2558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0117 0.2631
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0045 0.0886
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0057 0.1253
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0071 0.009 0.0793
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0075 0.0075
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0092 0.0092
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0056 0.0056
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0005 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0020857 0.5 0.5
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0045 0.0045
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0088 0.0117 0.57
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0189 0.0189
Mycobacterium tuberculosis Conserved protein 0.0073 0.0092 0.1246
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.005 0.0975
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0022 0.0474
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0024 0.021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0016 0.033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0029 0.0029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0020857 0.5 0.5
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0187 0.0187
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0013 0.0583
Echinococcus multilocularis GPCR, family 2 0.0031 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0138
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0029 0.0596
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0092 0.2065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.009 0.0793
Schistosoma mansoni coup transcription factor 0.0071 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0020857 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0016 0.033
Loa Loa (eye worm) hypothetical protein 0.0073 0.0092 0.0817
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0145 0.021 0.1859
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0032 0.0691
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0020857 0.5 0.5
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0056 0.1098
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0044 0.0045 0.3609
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0092 0.0092
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.0117 0.1038
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0201 0.0201
Trypanosoma brucei unspecified product 0.0019 0.0005 0.0089
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0020857 0.5 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0088 0.0117 0.2296
Schistosoma mansoni chromodomain helicase DNA binding protein 0.002 0.0007 0.0007
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0104 0.2027
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.003 0.0023 0.02
Schistosoma mansoni chromobox protein 0.0084 0.0111 0.0111
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0254 0.0386 0.3413
Echinococcus multilocularis geminin 0.0671 0.1061 0.1061
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.0264 0.595
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0092 0.3509
Entamoeba histolytica hypothetical protein 0.0142 0.0205 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0022 0.0195
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0104 0.0104
Schistosoma mansoni survival motor neuron protein 0.0145 0.021 0.021
Brugia malayi hypothetical protein 0.0064 0.0078 0.0693
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0092 0.6424
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.001 0.001
Onchocerca volvulus 0.0037 0.0034 0.0723
Toxoplasma gondii FATC domain-containing protein 0.0017 0.0001 0.0042
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0045 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0038 0.0836
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0092 0.1801
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0142 0.0205 1
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0008 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0056 0.1242
Echinococcus multilocularis chromobox protein 1 0.0084 0.0111 0.0111
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.4843 0.7822 0.7822
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0127 0.3866
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0005 0.0107
Schistosoma mansoni retinoic acid receptor RXR 0.0020857 0.5 0.5
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0002
Leishmania major hypothetical protein, conserved 0.0099 0.0135 0.265
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0005 0.0048
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.0035 0.0035
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0017 0.0001 0.0001
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0003 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0019 0.0399
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.0035 0.0312
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0039 0.0038 0.0836
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0189 0.0189
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0021 0.0008 0.0072
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0075 0.0075
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0092 0.0817
Trichomonas vaginalis esterase, putative 0.0073 0.0092 0.2065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0037 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0016 0.033
Schistosoma mansoni DNA polymerase eta 0.0019 0.0005 0.0005
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0003 0.0022
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0002 0.0002
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0105 0.0144 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0003 0.0237
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0409 0.0638 0.0638
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0020857 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0035 0.0312
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.0189 0.1674
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0092 0.0817
Schistosoma mansoni steroid hormone receptor ad4bp 0.0020857 0.5 0.5
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0105 0.0144 1
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0092 0.4551
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0021 0.0008 0.0072
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0066 0.1298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0052 0.1138
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0071 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0031 0.0024 0.0024
Echinococcus granulosus chromobox protein 1 0.0084 0.0111 0.0111
Brugia malayi nuclear hormone receptor 0.0034 0.0029 0.0254
Brugia malayi Muscleblind-like protein 0.0148 0.0214 0.1895
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0045 0.0045
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0105 0.0144 0.2814
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0022 0.0436
Echinococcus granulosus FTZ F1 alpha 0.0071 0.009 0.009
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0019 0.0399
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0104 0.0916
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0038 0.0836
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0027 0.1883
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0088 0.0117 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.009 0.0793
Echinococcus multilocularis musashi 0.0055 0.0063 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0071 0.009 0.0793
Schistosoma mansoni GTP-binding protein alpha subunit 0.0018 0.0003 0.0003
Echinococcus granulosus ecdysone induced protein 78C 0.0020857 0.5 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.009 0.009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0071 0.009 0.009
Brugia malayi jmjC domain containing protein 0.0066 0.0081 0.0717
Loa Loa (eye worm) hypothetical protein 0.0039 0.0037 0.0325
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Brugia malayi Cytochrome P450 family protein 0.0029 0.0022 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0071 0.009 0.0793
Onchocerca volvulus 0.0055 0.0063 0.1382
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Echinococcus granulosus survival motor neuron protein 1 0.0713 0.113 0.113
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0071 0.009 0.009
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0039 0.0038 0.0836
Brugia malayi steroid hormone receptor 0.0071 0.009 0.0793
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0033 0.0288
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0018 0.0003 0.0003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0071 0.009 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0016 0.033
Loa Loa (eye worm) hypothetical protein 0.0020857 0.5 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0005 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0092 0.1808
Loa Loa (eye worm) hypothetical protein 0.0383 0.0595 0.5268
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0029 0.0029
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.0187 0.255
Trypanosoma cruzi target of rapamycin kinase 3 0.007 0.0088 0.1726
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0002 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0092 0.2065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0241 0.0366 0.0366
Mycobacterium ulcerans hypothetical protein 0.0024 0.0013 0.0388
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0111 0.2481
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0092 0.0092
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0127 0.3866
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0013 0.0583
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0071 0.009 0.009
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0189 0.0189
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0005 0.004
Onchocerca volvulus Huntingtin homolog 0.0249 0.0378 0.8545
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0005 0.0046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0409 0.0638 0.0638
Onchocerca volvulus 0.0052 0.0059 0.1287
Loa Loa (eye worm) hypothetical protein 0.0044 0.0045 0.04
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0071 0.009 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0022 0.0474
Mycobacterium ulcerans hypothetical protein 0.0073 0.0092 0.3509
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0032 0.0691
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0018 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0081 0.1799
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0022 0.0022
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0018 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0020857 0.5 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0022 0.0022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0409 0.0638 0.5643
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0127 0.8833
Schistosoma mansoni inositol monophosphatase 0.0073 0.0092 0.0092
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.0045 0.0045
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0127 0.0127
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0005 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0096 0.2156
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0104 0.2027
Brugia malayi CXXC zinc finger family protein 0.0113 0.0158 0.1396
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0003 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0088 0.1967
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.0003 0.0003
Mycobacterium tuberculosis Conserved protein 0.0073 0.0092 0.1246
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0071 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0031 0.0024 0.0024
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0187 0.0187
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0045 0.0886
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0081 0.1799
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0088 0.0117 0.0117
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0096 0.0131 0.1156
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0018 0.0003 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0071 0.009 0.0793
Brugia malayi hypothetical protein 0.0038 0.0035 0.0312
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0092 0.3494
Schistosoma mansoni GTP-binding protein alpha subunit 0.0018 0.0003 0.0003
Echinococcus granulosus lamin 0.0055 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0081 0.1799
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0003 0.0033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0092 0.0092
Brugia malayi CHD4 protein 0.002 0.0007 0.0063

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Activity (functional) = 29.9 % TP_TRANSPORTER: inhibition of Indoxyl sulfate uptake (Indoxyl sulfate: 2 uM, HVA: 1000 uM) in Xenopus laevis oocytes ChEMBL. 12358729
Activity (functional) = 40.9 % TP_TRANSPORTER: inhibition of benzylpenicillin uptake by Homovanillic acid at a concentration of 1000uM in Oat3-expressing oocyte cells ChEMBL. 14762099
Activity (ADMET) = 0 pm/min/mg Specific activity of expressed human recombinant UGT1A6 ChEMBL. 10836148
Activity (ADMET) = 0 pm/min/mg Specific activity of expressed human recombinant UGT1A9 ChEMBL. 10836148
IC50 (functional) = -6.5 Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay ChEMBL. 19734910
Km (functional) = 274 uM TP_TRANSPORTER: uptake in Xenopus laevis oocytes ChEMBL. 12679720
Potency (functional) = 0.0035 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for NFkB Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 895 ] ChEMBL. No reference
Potency (functional) = 0.0035 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.006 uM PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) = 0.0089 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.0178 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0461 uM PUBCHEM_BIOASSAY: Validation screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493125, AID504467] ChEMBL. No reference
Potency (functional) 0.0478 uM PUBCHEM_BIOASSAY: qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 0.5358 uM PubChem BioAssay. qHTS screen for enhancers of Arylsulfatase A (ASA1): LOPAC Validation Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 26.6541 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 42.2841 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 19734910

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

7 literature references were collected for this gene.

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