Detailed information for compound 56282

Basic information

Technical information
  • TDR Targets ID: 56282
  • Name: N-[1-[4-(4-cyanophenyl)phenoxy]-3-phenoxyprop an-2-yl]-N-hydroxyformamide
  • MW: 388.416 | Formula: C23H20N2O4
  • H donors: 1 H acceptors: 3 LogP: 4.54 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CN(C(COc1ccccc1)COc1ccc(cc1)c1ccc(cc1)C#N)O
  • InChi: 1S/C23H20N2O4/c24-14-18-6-8-19(9-7-18)20-10-12-23(13-11-20)29-16-21(25(27)17-26)15-28-22-4-2-1-3-5-22/h1-13,17,21,27H,15-16H2
  • InChiKey: VRDVYZAEYHXMTJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1-[[4-(4-cyanophenyl)phenoxy]methyl]-2-phenoxy-ethyl]-N-hydroxy-formamide
  • N-[1-[[4-(4-cyanophenyl)phenoxy]methyl]-2-phenoxyethyl]-N-hydroxyformamide
  • N-[1-[4-(4-cyanophenyl)phenoxy]-3-phenoxy-propan-2-yl]-N-hydroxy-methanamide
  • N-[1-[4-(4-cyanophenyl)phenoxy]-3-(phenoxy)propan-2-yl]-N-hydroxyformamide
  • N-[1-[[4-(4-cyanophenyl)phenoxy]methyl]-2-(phenoxy)ethyl]-N-hydroxy-formamide
  • N-[1-[[4-(4-cyanophenyl)phenoxy]methyl]-2-(phenoxy)ethyl]-N-hydroxyformamide
  • N-[1-[4-(4-cyanophenyl)phenoxy]-3-(phenoxy)propan-2-yl]-N-hydroxy-methanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0058 0.0208 0.0208
Giardia lamblia Fructose-bisphosphate aldolase 0.1174 0.5639 1
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0341 0.1586 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0067 0.0067
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0034 0.0034
Echinococcus multilocularis musashi 0.0054 0.0184 0.0184
Plasmodium falciparum phd finger protein, putative 0.0058 0.0208 0.1313
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0023 0.0057
Onchocerca volvulus 0.0054 0.0184 0.0382
Giardia lamblia Sirtuin type 2 0.0016 0.0003 0.0003
Onchocerca volvulus 0.0061 0.022 0.0459
Loa Loa (eye worm) hypothetical protein 0.0053 0.018 0.0443
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0166
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0208 0.1312
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0273 0.0481
Brugia malayi nuclear receptor NHR-88 0.002 0.0023 0.0057
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0125 0.0534 0.3365
Schistosoma mansoni rotamase 0.0066 0.0247 0.0247
Schistosoma mansoni rab6-interacting 0.002 0.0021 0.0021
Onchocerca volvulus 0.0054 0.0184 0.0382
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0093 0.0585
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0208 0.0287
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0057
Leishmania major phosphoglycerate kinase B, cytosolic 0.0341 0.1586 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0003 0.0003
Treponema pallidum penicillin-binding protein (pbp-3) 0.1483 0.7147 1
Trichomonas vaginalis chromobox protein, putative 0.0138 0.0597 0.1057
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0705 0.3355 0.8208
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0273 0.1719
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0515 0.0515
Echinococcus granulosus jumonji domain containing protein 0.0081 0.032 0.032
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.2176 0.2176
Brugia malayi follicle stimulating hormone receptor 0.0235 0.1068 0.2637
Brugia malayi beta-lactamase family protein 0.0072 0.0273 0.0673
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0023 0.0023
Brugia malayi Thioredoxin reductase 0.0047 0.0153 0.0377
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0402 0.1879 0.5425
Schistosoma mansoni jumonji domain containing protein 0.0152 0.0665 0.0665
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0022 0.0137
Trypanosoma brucei small ubiquitin-related modifier 0.0062 0.0223 0.1407
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0034 0.0057
Schistosoma mansoni blooms syndrome DNA helicase 0.0028 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0041
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0003 0.0018
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0085 0.0157
Toxoplasma gondii thioredoxin reductase 0.0047 0.0153 0.0963
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0023 0.0057
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0341 0.1586 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0034 0.0057
Onchocerca volvulus 0.0189 0.0845 0.1814
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0016 0.0003 0.0019
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0018
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0135 0.0238
Toxoplasma gondii endonuclease IV APN 0.0076 0.0294 0.1852
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0021 0.0021
Brugia malayi SET domain containing protein 0.0027 0.0056 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0034 0.0057
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0016 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0023 0.0057
Loa Loa (eye worm) hypothetical protein 0.0122 0.0515 0.1273
Leishmania major pyruvate kinase 0.0033 0.0085 0.0533
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.0035 0.0093 0.0159
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0035 0.0093 0.0179
Loa Loa (eye worm) beta-lactamase 0.0072 0.0273 0.0673
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.1325 0.6375 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0018
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0003 0.0008
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0003 0.0008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0216 0.1359
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0093 0.0162
Trypanosoma brucei DNA polymerase eta, putative 0.0171 0.0755 0.476
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0278 0.1275 0.1275
Schistosoma mansoni chromobox protein 0.0138 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0058 0.0208 0.0514
Echinococcus granulosus bloom syndrome protein 0.0044 0.0135 0.0135
Brugia malayi hypothetical protein 0.002 0.0021 0.0052
Toxoplasma gondii small ubiquitin family modifier, putative 0.0062 0.0223 0.1407
Echinococcus granulosus lamin dm0 0.0054 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0057
Brugia malayi Matrixin family protein 0.0042 0.0128 0.0315
Brugia malayi Protein cec-1. 0.0023 0.0034 0.0083
Loa Loa (eye worm) hypothetical protein 0.0072 0.0273 0.0673
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0018
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0017 0.0104
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0051 0.0173 0.1091
Schistosoma mansoni terminal deoxycytidyl transferase 0.012 0.0509 0.0509
Onchocerca volvulus 0.0031 0.0073 0.0141
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0021 0.0026 0.0064
Trypanosoma cruzi DNA damage repair protein, putative 0.0037 0.0105 0.0662
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0172 0.076 0.1876
Brugia malayi AF-10 protein 0.0019 0.0017 0.0041
Entamoeba histolytica hypothetical protein 0.0022 0.0028 0.0045
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0278 0.1275 0.8042
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.0508 0.0508
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0126 0.0539 0.1331
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0273 0.0423
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0505 0.1191
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0003 0.0003
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0051 0.0173 0.1091
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0003 0.0003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0184 0.0821 0.1283
Toxoplasma gondii peptidylprolyl isomerase 0.0065 0.0239 0.1507
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0023 0.0023
Echinococcus granulosus dna polymerase kappa 0.02 0.0897 0.0897
Schistosoma mansoni phosphoglycerate kinase 0.0341 0.1586 0.1586
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0051 0.0173 0.05
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0273 0.0481
Schistosoma mansoni hypothetical protein 0.0025 0.0043 0.0043
Leishmania major ATP-dependent phosphofructokinase 0.0216 0.0977 0.616
Plasmodium falciparum glutathione reductase 0.0047 0.0153 0.0963
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0038
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0003 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.0897 0.5659
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0135 0.0238
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0284 0.1306 0.3769
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0273 0.0787
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0036 0.0088
Brugia malayi glutaminase DH11.1 0.055 0.2601 0.6422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0023 0.0057
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0034 0.0083
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0208 0.0208
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0216 0.0532
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0034 0.0034
Echinococcus granulosus apoptotic protease activating factor 1 0.0031 0.0073 0.0073
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0125 0.0534 0.3365
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0189 0.0845 0.1496
Echinococcus granulosus neuropeptide s receptor 0.0463 0.2176 0.2176
Brugia malayi PHD-finger family protein 0.0019 0.0017 0.0041
Loa Loa (eye worm) 6-phosphofructokinase 0.0216 0.0977 0.2412
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0446 0.1289
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.0897 0.5659
Brugia malayi glutathione reductase 0.0047 0.0153 0.0377
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.012 0.0509 0.0509
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0021 0.0026 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.0897 0.5659
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0446 0.1289
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.005 0.0086
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0208 0.0208
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0015 0.0097
Echinococcus granulosus RUN 0.002 0.0021 0.0021
Brugia malayi steroid hormone receptor 0.002 0.0023 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0034 0.0213
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.011
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0273 0.0273
Echinococcus multilocularis Chromo domain 0.0023 0.0034 0.0034
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0184 0.0821 0.2025
Echinococcus multilocularis caspase 2 0.0031 0.0073 0.0073
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0076 0.0294 0.0672
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0085 0.0533
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0003 0.0003
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0727 0.3464 1
Schistosoma mansoni coup transcription factor 0.002 0.0023 0.0023
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0278 0.1275 0.1275
Leishmania major DNA polymerase kappa, putative 0.014 0.0605 0.3815
Echinococcus granulosus peregrin 0.0058 0.0208 0.0208
Brugia malayi NAD-dependent deacetylase SIRT1 0.0016 0.0003 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0207 0.1308
Entamoeba histolytica hypothetical protein 0.0023 0.0034 0.0054
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0034 0.0083
Schistosoma mansoni hypothetical protein 0.002 0.0021 0.0021
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0085 0.0148
Leishmania major DNA polymerase eta, putative 0.0171 0.0755 0.476
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0273 0.0787
Leishmania major DNA polymerase eta, putative 0.0088 0.0351 0.2216
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0016 0.0003 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0208 0.1313
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0034 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0273 0.1719
Brugia malayi Cell death protein 3 precursor 0.0031 0.0073 0.0181
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0038 0.0095
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0208 0.1312
Loa Loa (eye worm) hypothetical protein 0.0072 0.0273 0.0673
Loa Loa (eye worm) matrix metalloproteinase 0.0017 0.0008 0.002
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0057
Brugia malayi Matrixin family protein 0.0017 0.0008 0.002
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0017 0.0008 0.0019
Plasmodium falciparum small ubiquitin-related modifier 0.0062 0.0223 0.1407
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0023 0.0057
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0023 0.0023
Brugia malayi Heterochromatin protein 1 0.0138 0.0597 0.1475
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.0508 0.0508
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0208 0.0367
Loa Loa (eye worm) hypothetical protein 0.0072 0.0273 0.0673
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0021 0.0026 0.004
Toxoplasma gondii histone deacetylase SIR2 0.0051 0.0173 0.1091
Echinococcus granulosus caspase 2 0.0031 0.0073 0.0073
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0208 0.0364
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.0423 0.267
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0023 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0515 0.0515
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.0977 0.1728
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0016 0.0003 0.0019
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0278 0.1275 0.1275
Echinococcus multilocularis pyruvate kinase 0.0033 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0341 0.1586 0.3915
Loa Loa (eye worm) phosphofructokinase 0.0216 0.0977 0.2412
Chlamydia trachomatis transglycolase/transpeptidase 0.0701 0.3335 0.5213
Plasmodium vivax NAD-dependent deacetylase, putative 0.0051 0.0173 0.1091
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0018
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0021 0.0133
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0505 0.1457
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0273 0.0481
Echinococcus multilocularis lamin dm0 0.0054 0.0184 0.0184
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0216 0.1359
Mycobacterium ulcerans endonuclease IV 0.0076 0.0294 0.0456
Trypanosoma brucei SIR2-like protein 4, putative 0.0016 0.0003 0.0019
Echinococcus multilocularis geminin 0.0337 0.1563 0.1563
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0003 0.0018
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0216 0.0298
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0034 0.0213
Echinococcus granulosus lamin 0.0054 0.0184 0.0184
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.02 0.0897 0.159
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0093 0.0585
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0273 0.1719
Plasmodium falciparum phosphoglycerate kinase 0.0341 0.1586 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0023 0.0057
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0088 0.0351 0.2216
Mycobacterium ulcerans DNA polymerase IV 0.02 0.0897 0.1404
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0208 0.0321
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0021 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0015 0.0038
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0049 0.0049
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0015 0.0015
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0065 0.0239 0.1507
Schistosoma mansoni phosphoglycerate kinase 0.0341 0.1586 0.1586
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0003 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0494 0.3115
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0153 0.0377
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0189 0.0845 0.1496
Brugia malayi ecdysteroid receptor 0.002 0.0023 0.0057
Echinococcus granulosus pyruvate kinase 0.0017 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0034 0.0057
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0003 0.0008
Plasmodium vivax JmjC domain containing protein 0.0019 0.0015 0.0097
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0341 0.1586 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0191 0.0336
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0085 0.0209
Echinococcus multilocularis peregrin 0.0058 0.0208 0.0208
Trypanosoma cruzi DNA polymerase kappa, putative 0.02 0.0897 0.5659
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0023 0.0057
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0505 0.1457
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0034 0.0057
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0022 0.0137
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0854 0.4082 0.6403
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0085 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0105 0.0662
Trypanosoma cruzi DNA polymerase kappa, putative 0.02 0.0897 0.5659
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0057
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0184 0.0455
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0034 0.0213
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0268 0.0268
Schistosoma mansoni DNA polymerase eta 0.0171 0.0755 0.0755
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0189 0.0845 0.1496
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0028 0.0048
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0216 0.0622
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0039 0.0248
Echinococcus granulosus pyruvate kinase 0.0017 0.0006 0.0006
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0066 0.0247 0.0609
Plasmodium vivax SET domain protein, putative 0.0122 0.0515 0.325
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0062 0.0223 0.0223
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0085 0.0166
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0093 0.0159
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.002 0.0058
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0268 0.0662
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1174 0.5639 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0067 0.0166
Echinococcus granulosus FTZ F1 alpha 0.002 0.0023 0.0023
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0189 0.0845 0.1493
Onchocerca volvulus 0.0025 0.0043 0.0077
Echinococcus multilocularis pyruvate kinase 0.0017 0.0006 0.0006
Echinococcus granulosus pyruvate kinase 0.0033 0.0085 0.0085
Schistosoma mansoni phospholipase C beta 0.0017 0.0008 0.0008
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0015 0.0015
Echinococcus granulosus pyruvate kinase 0.0033 0.0085 0.0085
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0208 0.1313
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0026 0.0051 0.0321
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0015 0.0015
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0284 0.1306 0.2045
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0284 0.1306 0.8233
Toxoplasma gondii exonuclease III APE 0.006 0.0216 0.1359
Brugia malayi Phosphoglycerate kinase 0.0341 0.1586 0.3915
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0018 0.0013 0.0081
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0067 0.0166
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.0067 0.0424
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.005 0.0086
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0017 0.0104
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0023 0.0023
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.0301 0.0636
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0003 0.0008
Leishmania major basic transcription factor 3a, putative 0.0035 0.0093 0.0585
Trypanosoma cruzi DNA damage repair protein, putative 0.0037 0.0105 0.0662
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0023 0.0023
Plasmodium falciparum pyruvate kinase 0.0033 0.0085 0.0533
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0013 0.0032
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0093 0.0585
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0003 0.0003
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0085 0.0533
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0083
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0083
Echinococcus multilocularis Small ubiquitin modifier 2 0.0062 0.0223 0.0223
Trichomonas vaginalis chromobox protein, putative 0.0083 0.033 0.0583
Brugia malayi CHD4 protein 0.0023 0.0034 0.0083
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0021 0.0026 0.0026
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0216 0.1359
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0446 0.1289
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0021 0.0026 0.0064
Trypanosoma brucei DNA damage repair protein, putative 0.0037 0.0105 0.0662
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0184 0.0455
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0173 0.0305
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0017 0.0008 0.0049
Schistosoma mansoni loxhd1 0.002 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0088
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0067 0.0067
Trichomonas vaginalis esterase, putative 0.0072 0.0273 0.0481
Echinococcus multilocularis pyruvate kinase 0.0017 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0023 0.0057
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0015 0.0015
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0003 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0977 0.1731
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0018
Echinococcus multilocularis microtubule associated protein 2 0.2069 1 1
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0039 0.0045
Mycobacterium ulcerans NAD-dependent deacetylase 0.0051 0.0173 0.0267
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0026 0.0048 0.0303
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0446 0.1289
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0122 0.0515 0.0515
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1174 0.5639 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0105 0.016
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0003 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0018
Brugia malayi PHD-finger family protein 0.0058 0.0208 0.0514
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0023 0.0057
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0016 0.0003 0.0003
Mycobacterium ulcerans phosphoglycerate kinase 0.0341 0.1586 0.2485
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0184 0.0821 0.0821
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0015 0.0097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1174 0.5639 1
Leishmania major sir2-family protein-like protein 0.0016 0.0003 0.0019
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0039 0.0248
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.0897 0.5659
Mycobacterium ulcerans lipase LipD 0.0072 0.0273 0.0423
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0003 0.0003
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0016 0.0001 0.0009
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0153 0.0153
Echinococcus multilocularis dna polymerase eta 0.0171 0.0755 0.0755
Trypanosoma brucei phosphoglycerate kinase 0.0125 0.0534 0.3365
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0569 0.2697 0.6588
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0018 0.0013 0.0081
Schistosoma mansoni 6-phosphofructokinase 0.0216 0.0977 0.0977
Onchocerca volvulus 0.002 0.0021 0.0029
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.012 0.0509 0.1255
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0065 0.0239 0.1507
Echinococcus granulosus phd:f box containing protein 0.0019 0.0015 0.0015
Brugia malayi Variant SH3 domain containing protein 0.0126 0.0539 0.1331
Brugia malayi polk-prov protein 0.0117 0.0494 0.1219
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0023 0.0057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0023 0.0057
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0341 0.1586 0.2477
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0569 0.2697 0.4228
Entamoeba histolytica phosphoglycerate kinase, putative 0.0341 0.1586 0.2809
Entamoeba histolytica deoxycytidyl transferase, putative 0.012 0.0509 0.0897
Schistosoma mansoni lipoxygenase 0.0084 0.0332 0.0332
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.014 0.0605 0.1747
Plasmodium vivax glutathione reductase, putative 0.0047 0.0153 0.0963
Trypanosoma brucei DNA polymerase IV, putative 0.02 0.0897 0.5659
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0034 0.0034
Echinococcus granulosus chromatin regulatory protein sir2 0.0016 0.0003 0.0003
Schistosoma mansoni lamin 0.0054 0.0184 0.0184
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0085 0.0533
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0021 0.0133
Brugia malayi Hemopexin family protein 0.0025 0.0043 0.0107
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0848 0.4051 1
Loa Loa (eye worm) matrixin family protein 0.0038 0.0111 0.0273
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0003 0.0018
Brugia malayi Doublecortin family protein 0.002 0.0021 0.0052
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0093 0.0229
Trypanosoma cruzi DNA polymerase eta, putative 0.0088 0.0351 0.2216
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0065 0.0239 0.1507
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.005 0.0313
Schistosoma mansoni microtubule-associated protein tau 0.2069 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0003 0.0003
Schistosoma mansoni ap endonuclease 0.006 0.0216 0.0216
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0021 0.0026 0.0163
Leishmania major hypothetical protein, conserved 0.0058 0.0207 0.1308
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0034 0.0083
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0173 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0023 0.0057
Echinococcus granulosus histone lysine methyltransferase setb 0.0122 0.0515 0.0515
Echinococcus multilocularis chromatin regulatory protein sir2 0.0016 0.0003 0.0003
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0003 0.0008
Toxoplasma gondii ABC1 family protein 0.0072 0.0273 0.1719
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0017 0.0008 0.0049
Schistosoma mansoni 6-phosphofructokinase 0.0216 0.0977 0.0977
Plasmodium falciparum thioredoxin reductase 0.0047 0.0153 0.0963
Loa Loa (eye worm) sirtuin 4 0.0016 0.0003 0.0008
Brugia malayi hypothetical protein 0.0031 0.0073 0.0181
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0341 0.1586 0.4578
Trichomonas vaginalis DNA polymerase eta, putative 0.02 0.0897 0.159
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0057
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0341 0.1586 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0184 0.0821 0.5174
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0093 0.0585
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0061 0.022 0.0542
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0032
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0058 0.0207 0.1308
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0023 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0273 0.0273
Loa Loa (eye worm) doublecortin family protein 0.002 0.0021 0.0052
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0034 0.0057
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0016 0.0001 0.0009
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0058 0.0207 0.0365
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0341 0.1586 0.3854
Schistosoma mansoni hypothetical protein 0.0031 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0052
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0122 0.0515 0.0515
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0216 0.0377
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0039 0.0057
Brugia malayi hypothetical protein 0.0022 0.0028 0.007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1174 0.5639 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0039 0.0248
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0015 0.0015
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0016 0.0003 0.0003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0023 0.0023
Echinococcus multilocularis transcription factor btf3 0.0035 0.0093 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0003 0.0019
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0017 0.0008 0.0049
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0039 0.0057
Brugia malayi ImpB/MucB/SamB family protein 0.012 0.0509 0.1255
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0003 0.0018
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0018 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0171 0.0755 0.1864
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0003 0.0008
Mycobacterium tuberculosis Conserved protein 0.0072 0.0273 0.0787
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0189 0.0845 0.1496
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0085 0.0533
Schistosoma mansoni caspase-7 (C14 family) 0.0031 0.0073 0.0073
Onchocerca volvulus 0.0022 0.0028 0.0044
Toxoplasma gondii proteasome regulatory subunit 0.0021 0.0026 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0034 0.0057
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.002 0.0022 0.0137
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0273 0.0481
Echinococcus granulosus 6 phosphofructokinase 0.0216 0.0977 0.0977
Schistosoma mansoni hypothetical protein 0.0337 0.1563 0.1563
Leishmania major hypothetical protein, conserved 0.0072 0.0273 0.1719
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1174 0.5639 1
Trypanosoma brucei unspecified product 0.018 0.0801 0.505
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0285 0.1314 0.3792
Echinococcus multilocularis dna polymerase kappa 0.02 0.0897 0.0897
Brugia malayi nuclear hormone receptor 0.002 0.0023 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0273 0.0481
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0977 0.1731
Schistosoma mansoni glutaminase 0.055 0.2601 0.2601
Echinococcus granulosus geminin 0.0337 0.1563 0.1563
Onchocerca volvulus 0.0023 0.0034 0.0056
Echinococcus multilocularis flap endonuclease 1 0.0026 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0085 0.0209
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0051 0.0173 0.1091
Echinococcus multilocularis pyruvate kinase 0.0033 0.0085 0.0085
Brugia malayi Matrixin family protein 0.0017 0.0008 0.002
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.002 0.0022 0.0029
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.2176 0.2176
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0284 0.1306 0.3164
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0208 0.1312
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0018
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0003 0.0003
Giardia lamblia DINP protein human, muc B family 0.014 0.0605 0.1071
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.0897 0.5659
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0034 0.0057
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0131 0.0561 0.1618
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0022 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1174 0.5639 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0039 0.0057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0023 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0216 0.038
Mycobacterium ulcerans epimerase 0.002 0.0021 0.0028
Brugia malayi Pre-SET motif family protein 0.0848 0.4051 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0034 0.0057
Treponema pallidum phosphoglycerate kinase 0.0341 0.1586 0.2216
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0023 0.0057
Onchocerca volvulus 0.0965 0.4621 1
Giardia lamblia Pyruvate kinase 0.0017 0.0006 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0301 0.0532
Plasmodium vivax phosphoglycerate kinase, putative 0.0341 0.1586 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0081 0.0513
Schistosoma mansoni chromobox protein 0.0023 0.0034 0.0034
Leishmania major phosphoglycerate kinase C, glycosomal 0.0341 0.1586 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0278 0.1275 0.3149
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0208 0.0367
Plasmodium vivax DNA repair protein REV1, putative 0.0037 0.0105 0.0662
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0017 0.0008 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0247 0.0435
Onchocerca volvulus 0.0072 0.0273 0.0574
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0023 0.0023
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0085 0.0209
Chlamydia trachomatis transglycolase/transpeptidase 0.1329 0.6394 1
Onchocerca volvulus Alhambra homolog 0.0058 0.0208 0.0434
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.1329 0.6394 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0034 0.0057
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0065 0.0239 0.1507
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.0977 0.1728
Trypanosoma brucei phosphoglycerate kinase 0.0341 0.1586 1
Entamoeba histolytica Flap nuclease, putative 0.0026 0.005 0.0083
Loa Loa (eye worm) glutathione reductase 0.0047 0.0153 0.0377
Loa Loa (eye worm) helicase 0.0023 0.0034 0.0083
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0705 0.3355 0.526
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0208 0.1312
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0034 0.0213
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0072 0.0273 0.0673
Schistosoma mansoni thyroid hormone receptor 0.002 0.0023 0.0023
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0021 0.0026 0.0076
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0041 0.0124 0.0124
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0153 0.0963
Brugia malayi jmjC domain containing protein 0.0192 0.0856 0.2114
Echinococcus granulosus intermediate filament protein 0.0054 0.0184 0.0184
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0273 0.0423
Trichomonas vaginalis hypothetical protein 0.0023 0.0034 0.0057
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0278 0.1275 0.3149
Trichomonas vaginalis chromobox protein, putative 0.0138 0.0597 0.1057
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0015 0.0097
Treponema pallidum hypothetical protein 0.0284 0.1306 0.1824
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0023 0.0033
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0085 0.0533
Toxoplasma gondii histone deacetylase SIR2-like 0.0016 0.0003 0.0019
Schistosoma mansoni chromatin regulatory protein sir2 0.0051 0.0173 0.0173
Loa Loa (eye worm) RecQ helicase 0.0044 0.0135 0.0334
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0085 0.0533
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0278 0.1275 0.8042
Brugia malayi Flap endonuclease-1 0.0026 0.005 0.0123
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.007
Trypanosoma brucei unspecified product 0.0083 0.0327 0.2061
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0573 0.2715 0.7838
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.002
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0335 0.0335
Giardia lamblia Hypothetical protein 0.0016 0.0003 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0034 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.02 0.0897 0.5659
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.005 0.0313
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0017 0.0104
Trypanosoma brucei phosphoglycerate kinase 0.0341 0.1586 1
Echinococcus granulosus chromobox protein 2 0.0023 0.0034 0.0034
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0216 0.0977 0.1364
Echinococcus granulosus Chromo domain 0.0023 0.0034 0.0034
Schistosoma mansoni flap endonuclease-1 0.0023 0.0038 0.0038
Trypanosoma brucei chrX additional, unordered contigs 0.0037 0.0105 0.0662
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0208 0.0367
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0034 0.0057
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.0897 0.5659
Plasmodium falciparum thioredoxin reductase 0.0016 0.0003 0.0018
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0034 0.0034
Onchocerca volvulus 0.002 0.0023 0.0033
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0023 0.0034 0.0034
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.005 0.0313
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0159 0.0696 0.1087
Schistosoma mansoni chromobox protein 0.0138 0.0597 0.0597
Echinococcus granulosus phosphoglycerate kinase 1 0.0341 0.1586 0.1586
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0016 0.0003 0.0003
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0063 0.0156
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0294 0.1852
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0184 0.0821 0.0821
Brugia malayi beta-NAC-like protein 0.0035 0.0093 0.0229
Brugia malayi Bromodomain containing protein 0.0058 0.0208 0.0514
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0278 0.1275 0.8042
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0016 0.0003 0.0019
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0034 0.0034
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0268 0.0268
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0216 0.1359
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0034 0.0054
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0039 0.0051
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0039 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0023 0.0057
Trypanosoma cruzi small ubiquitin protein, putative 0.0062 0.0223 0.1407
Echinococcus granulosus Solute carrier family 22 5 0.1031 0.4942 0.4942
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0207 0.1308
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0159 0.0696 0.2008
Echinococcus granulosus dna polymerase eta 0.0171 0.0755 0.0755
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0023 0.0023
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0181
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0083
Brugia malayi Matrixin family protein 0.0017 0.0008 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0015 0.0038
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0023 0.0033
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0051 0.0173 0.0302
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0153 0.0441
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0208 0.1312
Mycobacterium ulcerans hydrolase 0.0021 0.0026 0.0037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0093 0.0162
Schistosoma mansoni chromobox protein 0.0023 0.0034 0.0034
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0067 0.0067
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0159 0.0696 0.1661
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0208 0.0367
Trichomonas vaginalis set domain proteins, putative 0.0965 0.4621 0.8195
Mycobacterium tuberculosis Conserved hypothetical protein 0.012 0.0509 0.1468
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0605 0.3815
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0301 0.0532
Leishmania major hypothetical protein, conserved 0.0019 0.0015 0.0097
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0015 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0023 0.0057
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0052
Onchocerca volvulus Matrix metalloproteinase homolog 0.0038 0.0111 0.0223
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0067 0.0424
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0273 0.0787
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0003 0.0003
Echinococcus granulosus pyruvate kinase 0.0017 0.0006 0.0006
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0039 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0093 0.0162
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0023 0.0023
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0335 0.0827
Brugia malayi jmjC domain containing protein 0.0019 0.0015 0.0038
Echinococcus granulosus flap endonuclease 1 0.0026 0.005 0.005
Echinococcus multilocularis apoptotic protease activating factor 1 0.0031 0.0073 0.0073
Schistosoma mansoni pyruvate kinase 0.0033 0.0085 0.0085
Trypanosoma brucei phosphoglycerate kinase, putative 0.0125 0.0534 0.3365
Leishmania major phospholipase c-like protein 0.0018 0.0013 0.0081
Echinococcus granulosus transcription factor btf3 0.0035 0.0093 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.0897 0.5659
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0144 0.0626 0.0626
Schistosoma mansoni ap endonuclease 0.006 0.0216 0.0216
Onchocerca volvulus 0.0018 0.0013 0.0011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0034 0.0057
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0038 0.0038
Echinococcus granulosus chromobox protein 1 0.0138 0.0597 0.0597
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0067 0.0424
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0003 0.0003
Onchocerca volvulus Matrilysin homolog 0.0038 0.0111 0.0223
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0216 0.0977 0.282
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0015 0.0015
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0034 0.0057
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0278 0.1275 0.2258
Echinococcus multilocularis pyruvate kinase 0.0026 0.0051 0.0051
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0216 0.0532
Echinococcus multilocularis expressed protein 0.0066 0.0247 0.0247
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0216 0.1359
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0216 0.0333
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0189 0.0845 0.1493
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0208 0.0321
Plasmodium falciparum flap endonuclease 1 0.0026 0.005 0.0313
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0018 0.0013 0.0013
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0034 0.0054
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0057
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0017
Onchocerca volvulus 0.0023 0.0034 0.0056
Mycobacterium ulcerans beta-lactamase 0.0072 0.0273 0.0423
Mycobacterium ulcerans 6-phosphofructokinase 0.0216 0.0977 0.1529
Onchocerca volvulus 0.0144 0.0626 0.1339
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.0977 0.1728
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0216 0.0334
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0085 0.0166
Mycobacterium ulcerans hypothetical protein 0.0072 0.0273 0.0423
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0081 0.0139
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0727 0.3464 0.5432
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0038
Echinococcus multilocularis ubiquitin 0.0022 0.0028 0.0028
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0189 0.0845 0.2085
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0034 0.0057
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0189 0.0845 0.1321
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0051 0.0173 0.1091
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0006 0.0039
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0006 0.0039
Echinococcus multilocularis chromobox protein 1 0.0138 0.0597 0.0597
Brugia malayi Matrixin family protein 0.0017 0.0008 0.002
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.012 0.0509 0.0509
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0085 0.0244
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0273 0.0787
Loa Loa (eye worm) matrixin family protein 0.0042 0.0128 0.0315
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0021 0.0026 0.0065
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0184 0.0455
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0018 0.0013 0.0032
Treponema pallidum hypothetical protein 0.0159 0.0696 0.097
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0189 0.0845 0.1496
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0216 0.038
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0505 0.1457
Brugia malayi jmjC domain containing protein 0.0071 0.0268 0.0662
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0208 0.0514
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0208 0.1313
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0019
Echinococcus multilocularis 6 phosphofructokinase 0.0216 0.0977 0.0977
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0573 0.2715 0.6634
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0036 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0034 0.0213
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0216 0.0216
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0402 0.1879 0.4575
Onchocerca volvulus 0.0085 0.0335 0.0709
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0039 0.0248
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0085 0.0148
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0021 0.0028
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.2154 0.6217
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0216 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0034 0.0057
Chlamydia trachomatis endonuclease IV 0.0076 0.0294 0.0455
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0057
Schistosoma mansoni lipoxygenase 0.012 0.0508 0.0508
Mycobacterium tuberculosis Conserved protein 0.0072 0.0273 0.0787
Giardia lamblia Transcriptional regulator, Sir2 family 0.0051 0.0173 0.0305
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0021 0.006
Loa Loa (eye worm) glutaminase 2 0.055 0.2601 0.6422
Schistosoma mansoni lamin 0.0054 0.0184 0.0184
Echinococcus multilocularis pyruvate kinase 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.002
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.0856 0.0856
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0021 0.0021
Onchocerca volvulus Cell death protein 3 homolog 0.0031 0.0073 0.0141
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0335 0.0335
Entamoeba histolytica hypothetical protein 0.0024 0.0039 0.0064
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0125 0.0534 0.3365
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0034 0.0057
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0017 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.0423 0.267
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0003 0.0003
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0039 0.0248
Echinococcus multilocularis phosphoglycerate kinase 1 0.0341 0.1586 0.1586
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0023 0.0023
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0023 0.0023
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0003
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0335 0.0335
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0021 0.0026 0.0163
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0003 0.0018
Loa Loa (eye worm) heterochromatin protein 1 0.0138 0.0597 0.1475
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0063 0.0156
Brugia malayi phosphofructokinase 0.0216 0.0977 0.2412
Loa Loa (eye worm) Plcb4 protein 0.0017 0.0008 0.0019
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0021 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0023 0.0057
Schistosoma mansoni DNA helicase recq5 0.003 0.0067 0.0067
Echinococcus multilocularis chromobox protein 1 0.0138 0.0597 0.0597
Plasmodium falciparum glutathione reductase 0.0016 0.0003 0.0018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.0494 0.0494
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0015 0.0015
Leishmania major silent information regulator 2, putative 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0181
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1174 0.5639 1
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0023 0.0023
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0023 0.0023
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0569 0.2697 0.7784
Brugia malayi beta-lactamase family protein 0.0072 0.0273 0.0673
Leishmania major pyruvate kinase 0.0033 0.0085 0.0533
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0034 0.0057
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.0067 0.0117
Onchocerca volvulus 0.0072 0.0273 0.0574
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0446 0.1289
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0273 0.062
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0034 0.0057
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0273 0.0787
Brugia malayi hypothetical protein 0.002 0.0021 0.0052
Plasmodium falciparum DNA repair protein REV1, putative 0.0037 0.0105 0.0662
Giardia lamblia PHD finger protein 15 0.0058 0.0208 0.0367
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0216 0.0216
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0273 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.0897 0.5659
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0034 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0208 0.0367
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0017 0.0104
Brugia malayi intermediate filament protein 0.0054 0.0184 0.0455
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0083
Onchocerca volvulus 0.0018 0.0013 0.0011
Trypanosoma brucei unspecified product 0.0083 0.0327 0.2061
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0021 0.0051
Trichomonas vaginalis glutaminase, putative 0.055 0.2601 0.4612
Loa Loa (eye worm) hypothetical protein 0.0072 0.0273 0.0673
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0705 0.3355 0.9684
Leishmania major trypanothione reductase 0.0047 0.0153 0.0963
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0153 0.0963
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0125 0.0534 0.3365
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0016 0.0001 0.0001
Loa Loa (eye worm) 6-phosphofructokinase 0.0216 0.0977 0.2412
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0216 0.0977 0.2354
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0023 0.0057
Schistosoma mansoni thyroid hormone receptor 0.002 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0105 0.0662
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0015 0.0015
Schistosoma mansoni rab6-interacting 0.002 0.0021 0.0021
Trypanosoma cruzi small ubiquitin protein, putative 0.0062 0.0223 0.1407
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0034 0.0057
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0216 0.1359
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0016 0.0001 0.0009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0023 0.0023
Brugia malayi Pre-SET motif family protein 0.0122 0.0515 0.1273
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0081 0.0142
Echinococcus granulosus chromobox protein 1 0.0138 0.0597 0.0597
Schistosoma mansoni pyruvate kinase 0.0017 0.0006 0.0006
Brugia malayi jmjC domain containing protein 0.0019 0.0015 0.0038
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0085 0.0209
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0034 0.0083
Leishmania major DNA polymerase kappa, putative 0.0037 0.0105 0.0662
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0034 0.0057
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.032 0.032
Mycobacterium tuberculosis Conserved protein 0.0072 0.0273 0.0787
Trichomonas vaginalis rotamase, putative 0.0066 0.0247 0.0435
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0023 0.0023
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0085 0.0166
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0017 0.0104
Entamoeba histolytica ubiquitin like protein 0.0062 0.0223 0.0391
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) glutaminase 0.055 0.2601 0.6422
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0034 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1174 0.5639 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0412 0.1016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1174 0.5639 1
Brugia malayi 6-phosphofructokinase 0.0216 0.0977 0.2412
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0063 0.0231 0.0231
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0273 0.0787
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0294 0.1852
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.1068 0.2637
Schistosoma mansoni pyruvate kinase 0.0033 0.0085 0.0085
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0063 0.0231 0.0231
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.2176 0.2176
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0208 0.1312
Giardia lamblia Phosphoglycerate kinase 0.0341 0.1586 0.2811
Trichomonas vaginalis chromobox protein, putative 0.0083 0.033 0.0583
Echinococcus granulosus expressed protein 0.0066 0.0247 0.0247
Brugia malayi Phosphoglycerate kinase 0.0125 0.0534 0.1318
Brugia malayi ImpB/MucB/SamB family protein 0.0171 0.0755 0.1864
Schistosoma mansoni hypothetical protein 0.0023 0.0034 0.0034
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0273 0.0787
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0208 0.1312
Brugia malayi hypothetical protein 0.0023 0.0034 0.0083
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0034 0.0213
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0023 0.0023
Echinococcus multilocularis RUN 0.002 0.0021 0.0021
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0081 0.0513
Schistosoma mansoni intermediate filament proteins 0.0054 0.0184 0.0184
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0284 0.1306 0.8233
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1174 0.5639 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0021 0.0021
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0278 0.1275 0.8042
Loa Loa (eye worm) SMO-1 protein 0.0062 0.0223 0.0551
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0573 0.2715 0.4257
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0216 0.0977 0.616
Echinococcus granulosus Chromobox protein 3 0.0023 0.0034 0.0034
Chlamydia trachomatis pyruvate kinase 0.0033 0.0085 0.0128
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0977 0.1731
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0023 0.0057
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0076 0.0294 0.0725
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.012 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0076 0.0294 0.0725
Trypanosoma cruzi DNA polymerase eta, putative 0.0171 0.0755 0.476
Schistosoma mansoni DNA polymerase IV / kappa 0.0037 0.0105 0.0105
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0184 0.0821 0.2369
Echinococcus multilocularis lamin 0.0054 0.0184 0.0184
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0189 0.0845 0.2085
Brugia malayi beta-lactamase 0.0072 0.0273 0.0673
Entamoeba histolytica hypothetical protein 0.0023 0.0034 0.0054
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0016 0.0003 0.0019
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0023 0.0023
Plasmodium vivax phospholipase C-like, putative 0.0017 0.0008 0.0049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0083
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0003
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0006 0.0039
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0023 0.0023
Onchocerca volvulus 0.002 0.0021 0.0029
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0125 0.0534 0.3365
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0273 0.0273
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0039 0.0113
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0125 0.0534 0.3365
Schistosoma mansoni polycystin 1-related 0.002 0.0021 0.0021
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0016 0.0001 0.0001
Treponema pallidum fructose-bisphosphate aldolase 0.1174 0.5639 0.7889
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0034 0.0057
Mycobacterium ulcerans hypothetical protein 0.002 0.0021 0.0028
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0015 0.0038
Mycobacterium ulcerans glutaminase 0.055 0.2601 0.4078
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0085 0.0209
Giardia lamblia Pyruvate kinase 0.0033 0.0085 0.0148
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0003 0.0018
Echinococcus multilocularis transcription factor Dp 1 0.0161 0.0706 0.0706
Chlamydia trachomatis phosphoglycerate kinase 0.0341 0.1586 0.2477
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0023 0.0034 0.0034
Echinococcus granulosus Small ubiquitin modifier 2 0.0062 0.0223 0.0223
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0003 0.0003
Mycobacterium ulcerans DNA polymerase IV 0.02 0.0897 0.1404
Giardia lamblia Sentrin 0.0062 0.0223 0.0393
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0023 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0494 0.3115
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.033 0.0698
Schistosoma mansoni nuclear hormone receptor 0.002 0.0023 0.0023
Brugia malayi jmjC domain containing protein 0.0019 0.0015 0.0038
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0003 0.0018
Treponema pallidum penicillin-binding protein (pbp-2) 0.0854 0.4082 0.5711
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0016 0.0003 0.0003
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0016 0.0003 0.0003
Loa Loa (eye worm) proteasome 26S subunit 0.0016 0.0001 0.0003
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0085 0.0209
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0057 0.0202 0.1271
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0184 0.0821 0.0821
Trypanosoma brucei DNA damage repair protein, putative 0.0037 0.0105 0.0662
Giardia lamblia DNA damage repair protein 0.0037 0.0105 0.0184
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0034 0.0213
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.0239 0.0419
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0105 0.0662
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0189 0.0845 0.1496
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0003 0.0018
Leishmania major DNA damage repair protein, putative 0.0037 0.0105 0.0662
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0051 0.0173 0.1091
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0015 0.0097
Mycobacterium tuberculosis Probable reductase 0.0107 0.0446 0.1289
Treponema pallidum penicillin-binding protein (pbp-1) 0.1329 0.6394 0.8947
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0208 0.0367
Brugia malayi Ubiquitin-like protein SMT3 0.0062 0.0223 0.0551
Trypanosoma cruzi DNA polymerase kappa, putative 0.02 0.0897 0.5659
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0121 0.0765
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0017 0.0104
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0083
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0105 0.0662
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0023 0.0023
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0021 0.0021
Mycobacterium leprae PROBABLE HYDROLASE 0.0021 0.0026 0.0014
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0034 0.0054
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.0511 0.1263
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0003 0.0003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0003
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0003 0.0018
Echinococcus multilocularis chromobox protein 2 0.0023 0.0034 0.0034
Echinococcus granulosus transcription factor Dp 1 0.0161 0.0706 0.0706
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0016 0.0003 0.0003
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.005 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.0423 0.267
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0216 0.0977 0.616
Loa Loa (eye worm) CHromoDomain protein family member 0.0023 0.0034 0.0083
Schistosoma mansoni hypothetical protein 0.0337 0.1563 0.1563
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0184 0.0821 0.1283
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0122
Mycobacterium leprae Probable lipase LipE 0.0072 0.0273 0.062
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.0897 0.5659
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0016 0.0001 0.0009
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0034 0.0213
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0003 0.0003
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0093 0.0585
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0854 0.4082 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0057
Brugia malayi jmjC domain containing protein 0.0019 0.0015 0.0038
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0341 0.1586 0.2811
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0023 0.0057
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0341 0.1586 0.2811
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0085 0.0335 0.0827
Onchocerca volvulus 0.0072 0.0273 0.0574
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0208 0.0367
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0034 0.0034
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0273 0.1719
Loa Loa (eye worm) hypothetical protein 0.0117 0.0494 0.1219
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0018 0.0013 0.0081
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0977 0.1731
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.014 0.0605 0.3815
Trichomonas vaginalis rotamase, putative 0.0065 0.0239 0.0421
Echinococcus granulosus ubiquitin 0.0022 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0065
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0058 0.0207 0.0365
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0034 0.0057
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0727 0.3464 0.8478
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0446 0.1048
Leishmania major small ubiquitin protein, putative 0.0062 0.0223 0.1407
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0022 0.0137
Trichomonas vaginalis ubiquitin, putative 0.0022 0.0028 0.0048
Loa Loa (eye worm) hypothetical protein 0.0054 0.0184 0.0455
Plasmodium vivax small ubiquitin-related modifier, putative 0.0062 0.0223 0.1407
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0189 0.0845 0.1496
Loa Loa (eye worm) hypothetical protein 0.013 0.0558 0.1376
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0273 0.0673
Trypanosoma brucei trypanothione reductase 0.0047 0.0153 0.0963
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0023 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0515 0.0515
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0067 0.0067
Schistosoma mansoni transcription factor btf3 0.0035 0.0093 0.0093
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0105 0.0662
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0135 0.0334
Entamoeba histolytica hypothetical protein 0.0023 0.0034 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0023 0.0057
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0083
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0135 0.0135
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0093 0.0585
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.005 0.0123
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.005 0.0313
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.0856 0.0856
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0015 0.0015
Brugia malayi chromobox protein homolog 3 0.0078 0.0301 0.0744
Loa Loa (eye worm) hypothetical protein 0.0078 0.0301 0.0744
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0049 0.0049
Brugia malayi 6-phosphofructokinase 0.0216 0.0977 0.2412
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0191 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0854 0.4082 0.7239
Trypanosoma brucei DNA polymerase IV, putative 0.018 0.0801 0.505
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0066 0.0247 0.0609
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0153 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0223 0.0393
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0076 0.0294 0.0848
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0273 0.0673
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0023 0.0057
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0081 0.0513
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0023 0.0033
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0067 0.0166
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0015 0.0015
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0173 0.0305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0018
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0016 0.0003 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0023 0.0023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0122 0.0515 0.325
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0003 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.02 0.0897 0.5659
Loa Loa (eye worm) hypothetical protein 0.0072 0.0273 0.0673
Schistosoma mansoni DNA helicase recq1 0.003 0.0067 0.0067
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0021 0.0026 0.0064
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0208 0.0208
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0208 0.0367
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0034 0.0213
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0015 0.0097

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 130 uM In vitro inhibition of Matrix metalloproteinase-3 ChEMBL. 11412979
IC50 (binding) = 130 uM In vitro inhibition of Matrix metalloproteinase-3 ChEMBL. 11412979
IC50 (binding) = 260 uM In vitro inhibition of Matrix metalloproteinase-2 ChEMBL. 11412979
IC50 (binding) = 260 uM In vitro inhibition of Matrix metalloproteinase-2 ChEMBL. 11412979
IC50 (binding) > 10000 uM In vitro inhibition of Matrix metalloproteinase-1. ChEMBL. 11412979
IC50 (binding) > 10000 uM In vitro inhibition of Matrix metalloproteinase-1. ChEMBL. 11412979
T1/2 (ADMET) 0 hr Half life of the compound determined in rat by intravenous administration; Not determined ChEMBL. 11412979
T1/2 (ADMET) < 1 hr Half life of the compound after iv administration to cynomolgus monkey ChEMBL. 11412979

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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