Detailed information for compound 595844

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 468.27 | Formula: C19H17BrF3N5O
  • H donors: 2 H acceptors: 3 LogP: 4.21 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cnc(c(c1)C(=O)Nc1ccc(cc1)C(F)(F)F)NCCCn1cncc1
  • InChi: 1S/C19H17BrF3N5O/c20-14-10-16(17(26-11-14)25-6-1-8-28-9-7-24-12-28)18(29)27-15-4-2-13(3-5-15)19(21,22)23/h2-5,7,9-12H,1,6,8H2,(H,25,26)(H,27,29)
  • InChiKey: VGPIHFKESCPUPH-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0006 0.0013 0.5
Echinococcus multilocularis regulator of G protein signaling 3 0.001 0.0066 0.0059
Schistosoma mansoni ferritin 0.0008 0.0046 0.0036
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.001 0.0066 0.0059
Loa Loa (eye worm) acetyltransferase 0.0149 0.2044 0.7222
Plasmodium vivax SET domain protein, putative 0.003 0.0348 0.6322
Echinococcus multilocularis lamin dm0 0.0028 0.0322 0.0315
Onchocerca volvulus 0.0006 0.0013 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0208
Toxoplasma gondii microneme protein MIC17C 0.0015 0.0147 0.0412
Echinococcus granulosus retinol dehydrogenase 11 0.0006 0.0013 0.0005
Trypanosoma cruzi short chain dehydrogenase, putative 0.0006 0.0013 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.0019
Onchocerca volvulus 0.0048 0.0616 0.1883
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0006 0.0013 0.0008
Echinococcus granulosus lamin dm0 0.0028 0.0322 0.0315
Brugia malayi chromobox protein homolog 3 0.002 0.021 0.0719
Brugia malayi Regulator of G protein signaling domain containing protein 0.001 0.0066 0.0211
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0159 0.0151
Brugia malayi oxidoreductase 0.0006 0.0013 0.0022
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Echinococcus granulosus regulator of G protein signaling 3 0.001 0.0066 0.0059
Brugia malayi PAN domain containing protein 0.0015 0.0147 0.0499
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.06 0.0593
Echinococcus multilocularis transient receptor potential cation channel 0.0006 0.0013 0.0005
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0066 0.0056
Schistosoma mansoni hypothetical protein 0.0038 0.0464 0.0454
Loa Loa (eye worm) dehydrogenase 0.0006 0.0013 0.0019
Loa Loa (eye worm) oxidoreductase 0.0006 0.0013 0.0019
Trypanosoma brucei oxidoreductase-like protein 0.0006 0.0013 0.5
Brugia malayi SET domain containing protein 0.0007 0.003 0.0083
Echinococcus multilocularis chromobox protein 1 0.0035 0.043 0.0423
Brugia malayi Protein cec-1. 0.0006 0.001 0.0013
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Echinococcus multilocularis regulator of G protein signaling 0.001 0.0066 0.0059
Schistosoma mansoni axis inhibition protein axin 0.001 0.0066 0.0056
Brugia malayi MH2 domain containing protein 0.0009 0.0049 0.0151
Schistosoma mansoni hypothetical protein 0.0016 0.0159 0.0148
Schistosoma mansoni regulator of G protein signaling 0.001 0.0066 0.0056
Loa Loa (eye worm) CXXC zinc finger family protein 0.0015 0.0135 0.0452
Onchocerca volvulus 0.0006 0.0013 0.0008
Echinococcus multilocularis ferritin 0.0008 0.0046 0.0039
Brugia malayi MH1 domain containing protein 0.0009 0.0049 0.0151
Toxoplasma gondii microneme protein MIC17B 0.0015 0.0147 0.0412
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0499 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0032 0.0387 0.1134
Echinococcus granulosus tumor protein p63 0.0331 0.4627 0.4623
Schistosoma mansoni steroid dehydrogenase 0.0006 0.0013 0.0002
Schistosoma mansoni chromobox protein 0.0035 0.043 0.042
Onchocerca volvulus Heterochromatin protein 1 homolog 0.002 0.021 0.0619
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Schistosoma mansoni regulator of G protein signaling 0.001 0.0066 0.0056
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0328 0.0321
Loa Loa (eye worm) heterochromatin protein 1 0.0035 0.043 0.1498
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0057 0.0146
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Echinococcus granulosus axis inhibition protein axin 0.001 0.0066 0.0059
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0006 0.0013 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0036 0.0078
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0049 0.0148
Brugia malayi Heterochromatin protein 1 0.0035 0.043 0.1501
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0057 0.0146
Echinococcus multilocularis Chromo domain 0.0006 0.001 0.0003
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0006 0.0013 0.5
Trichomonas vaginalis chromobox protein, putative 0.0021 0.0231 0.0685
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0015 0.0147 0.0412
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0007 0.0022 0.0015
Loa Loa (eye worm) oxidoreductase 0.0006 0.0013 0.0019
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0147 0.0496
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1984 0.1978
Toxoplasma gondii oxidoreductase, putative 0.0006 0.0013 0.0007
Echinococcus granulosus Regulator of G protein signaling 20 0.001 0.0066 0.0059
Schistosoma mansoni steroid dehydrogenase 0.0006 0.0013 0.0002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0147 0.0496
Echinococcus granulosus Chromobox protein 3 0.0006 0.001 0.0003
Onchocerca volvulus 0.0015 0.0135 0.0388
Echinococcus multilocularis carbonyl reductase 1 0.0006 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.0019
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0147 0.0496
Loa Loa (eye worm) follicle stimulating hormone receptor 0.012 0.1637 0.5778
Loa Loa (eye worm) oxidoreductase 0.0006 0.0013 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0066 0.0174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.06 0.059
Onchocerca volvulus 0.0028 0.0322 0.0968
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0088 0.1184 1
Trichomonas vaginalis chromobox protein, putative 0.0035 0.043 0.1304
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0006 0.0013 0.0008
Brugia malayi hypothetical protein 0.0006 0.001 0.0013
Brugia malayi CHD4 protein 0.0007 0.0022 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0066 0.0174
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0006 0.0013 0.0008
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0066 0.0059
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0118 0.0111
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0006 0.001 0.0013
Echinococcus granulosus Smad4 0.0009 0.0049 0.0042
Plasmodium falciparum steroid dehydrogenase, putative 0.0006 0.0013 0.005
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0006 0.0013 0.0002
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0006 0.0013 0.5
Echinococcus multilocularis oxidoreductase 0.0006 0.0013 0.0005
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0006 0.0013 0.0005
Onchocerca volvulus 0.0232 0.3227 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0006 0.0013 0.0008
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0049 0.0039
Onchocerca volvulus 0.0015 0.0147 0.0426
Schistosoma mansoni carbonyl reductase 0.0006 0.0013 0.0002
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.001
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0046 1
Entamoeba histolytica hypothetical protein 0.0006 0.0013 0.005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0159 0.0151
Brugia malayi Associated with TFs and helicases family protein 0.0006 0.001 0.0013
Brugia malayi PXA domain containing protein 0.001 0.0066 0.0211
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.055 0.1679
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0006 0.0013 0.0008
Echinococcus multilocularis carbonyl reductase 1 0.0006 0.0013 0.0005
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Trypanosoma brucei short-chain dehydrogenase, putative 0.0006 0.0013 0.5
Brugia malayi hypothetical protein 0.0038 0.0464 0.1621
Echinococcus granulosus expressed protein 0.0189 0.2616 0.261
Loa Loa (eye worm) hypothetical protein 0.0015 0.0147 0.0496
Schistosoma mansoni intermediate filament proteins 0.0028 0.0322 0.0312
Trichomonas vaginalis steroid dehydrogenase, putative 0.0006 0.0013 0.0008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0159 0.0151
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.055 0.1679
Schistosoma mansoni steroid dehydrogenase 0.0006 0.0013 0.0002
Loa Loa (eye worm) oxidoreductase 0.0006 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0048 0.0616 0.2158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.06 0.0593
Onchocerca volvulus 0.0006 0.0013 0.0008
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0006 0.0013 0.0005
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0007 0.0022 0.0012
Echinococcus multilocularis Regulator of G protein signaling 20 0.001 0.0066 0.0059
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0322 0.1117
Echinococcus multilocularis steroid dehydrogenase 0.0006 0.0013 0.0005
Loa Loa (eye worm) oxidoreductase 0.0006 0.0013 0.0019
Echinococcus multilocularis chromobox protein 1 0.0035 0.043 0.0423
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0006 0.0013 0.005
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0006 0.0013 0.0008
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.2044 0.2038
Brugia malayi Valyl-tRNA synthetase 0.0006 0.001 0.0013
Echinococcus multilocularis beta adrenergic receptor kinase 0.001 0.0066 0.0059
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0007
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0007
Schistosoma mansoni ferritin 0.0008 0.0046 0.0036
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Brugia malayi dehydrogenases, short chain protein 9 0.0006 0.0013 0.0022
Trypanosoma brucei short-chain dehydrogenase, putative 0.0006 0.0013 0.5
Echinococcus granulosus beta-adrenergic receptor kinase 0.001 0.0066 0.0059
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0007
Schistosoma mansoni steroid dehydrogenase 0.0006 0.0013 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0066 0.0056
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0049 0.0042
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0147 0.0412
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0006 0.0013 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0088 0.1184 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0021 0.0231 0.0685
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.0019
Brugia malayi follicle stimulating hormone receptor 0.012 0.1637 0.5779
Brugia malayi PAN domain containing protein 0.0015 0.0147 0.0499
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0147 0.0412
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0013 0.5
Echinococcus multilocularis axis inhibition protein axin 0.001 0.0066 0.0059
Schistosoma mansoni retinal dehydrogenase 0.0006 0.0013 0.0002
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.001
Echinococcus multilocularis expressed protein 0.0008 0.0046 0.0039
Entamoeba histolytica hypothetical protein 0.001 0.0066 0.1146
Echinococcus granulosus carbonyl reductase 1 0.0006 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.0019
Onchocerca volvulus 0.0006 0.0013 0.0008
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.0019
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.2044 0.7222
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0616 0.0606
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0006 0.0013 0.0022
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.001 0.0066 0.0056
Trichomonas vaginalis ferritin, putative 0.0008 0.0046 0.0111
Schistosoma mansoni microtubule-associated protein tau 0.071 1 1
Entamoeba histolytica hypothetical protein 0.001 0.0066 0.1146
Trichomonas vaginalis conserved hypothetical protein 0.002 0.021 0.0619
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0046 1
Plasmodium vivax hypothetical protein, conserved 0.0006 0.0013 0.0235
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0013 0.5
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0049 0.0042
Loa Loa (eye worm) helicase 0.0006 0.001 0.001
Schistosoma mansoni regulator of G protein signaling 0.001 0.0066 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0066 0.0056
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0147 0.0496
Entamoeba histolytica short chain dehydrogenase family protein 0.0006 0.0013 0.005
Echinococcus multilocularis carbonyl reductase 1 0.0006 0.0013 0.0005
Brugia malayi PXA domain containing protein 0.001 0.0066 0.0211
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Schistosoma mansoni axis inhibition protein axin 0.001 0.0066 0.0056
Onchocerca volvulus 0.0015 0.0147 0.0426
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0046 0.0285
Echinococcus granulosus chromobox protein 2 0.0006 0.001 0.0003
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0006 0.0013 0.005
Schistosoma mansoni cpg binding protein 0.0015 0.0135 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0066 0.0174
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0006 0.0013 0.0022
Trypanosoma brucei short-chain dehydrogenase, putative 0.0006 0.0013 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0013 0.5
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.001 0.0066 0.0211
Trichomonas vaginalis set domain proteins, putative 0.0232 0.3227 1
Schistosoma mansoni hypothetical protein 0.0016 0.0159 0.0148
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0006 0.0013 0.0008
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.001 0.0066 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.021 0.0716
Loa Loa (eye worm) hypothetical protein 0.0015 0.0147 0.0496
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0088 0.1184 0.1175
Echinococcus multilocularis Chromobox protein 3 0.0006 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.001
Brugia malayi M-phase phosphoprotein, mpp8 0.0006 0.001 0.0013
Echinococcus granulosus carbonyl reductase 1 0.0006 0.0013 0.0005
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0006 0.0013 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0159 0.0538
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Entamoeba histolytica hypothetical protein 0.0038 0.0464 0.9292
Loa Loa (eye worm) Smad1 0.0009 0.0049 0.0148
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0006 0.0013 0.5
Toxoplasma gondii PAN domain-containing protein 0.024 0.3332 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.001
Brugia malayi PAN domain containing protein 0.0015 0.0147 0.0499
Schistosoma mansoni lamin 0.0028 0.0322 0.0312
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0088 0.1184 0.1177
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Onchocerca volvulus 0.0006 0.001 0.00000005406
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0006 0.0013 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0066 0.0174
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.06 0.2104
Schistosoma mansoni ferritin 0.0008 0.0046 0.0036
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0139 0.0469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.06 0.0593
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0348 0.0338
Entamoeba histolytica hypothetical protein 0.0038 0.0464 0.9292
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0007 0.0022 0.0015
Echinococcus granulosus cpg binding protein 0.0015 0.0147 0.0139
Entamoeba histolytica hypothetical protein, conserved 0.0006 0.0013 0.005
Onchocerca volvulus 0.0035 0.043 0.1305
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0013 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0006 0.0013 0.5
Echinococcus granulosus axis inhibition protein axin 0.001 0.0066 0.0059
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0006 0.0013 0.0005
Echinococcus granulosus WW domain containing oxidoreductase 0.0006 0.0013 0.0005
Brugia malayi hypothetical protein 0.0006 0.0013 0.0022
Brugia malayi Smad1 0.0009 0.0049 0.0151
Echinococcus multilocularis Smad4 0.0009 0.0049 0.0042
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0208
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0066 0.0059
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.001
Echinococcus multilocularis retinol dehydrogenase 11 0.0006 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.0019
Brugia malayi PAN domain containing protein 0.0015 0.0147 0.0499
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0078
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0006 0.0013 0.0008
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0083 0.11 0.3873
Echinococcus multilocularis expressed protein 0.0189 0.2616 0.261
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0006 0.0013 0.5
Trichomonas vaginalis chromobox protein, putative 0.0021 0.0231 0.0685
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0066 0.0059
Brugia malayi intermediate filament protein 0.0028 0.0322 0.1117
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0006 0.0013 0.0008
Schistosoma mansoni steroid dehydrogenase 0.0006 0.0013 0.0002
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0006 0.0013 0.5
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0066 0.0174
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Toxoplasma gondii hypothetical protein 0.0015 0.0147 0.0412
Brugia malayi PAN domain containing protein 0.0015 0.0147 0.0499
Toxoplasma gondii oxidoreductase, putative 0.0006 0.0013 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0348 0.0341
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0006 0.0013 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0118 0.0393
Brugia malayi hypothetical protein 0.0006 0.0013 0.0022
Loa Loa (eye worm) oxidoreductase 0.0006 0.0013 0.0019
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0006 0.0013 0.0008
Onchocerca volvulus 0.0006 0.0013 0.0008
Schistosoma mansoni carbonyl reductase 0.0006 0.0013 0.0002
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0088 0.1184 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.06 0.059
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0159 0.0538
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0322 0.1115
Brugia malayi MH2 domain containing protein 0.0009 0.0049 0.0151
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0006 0.0013 0.0005
Brugia malayi A-kinase anchor protein 10, precursor 0.001 0.0066 0.0211
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0066 0.0211
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0006 0.001 0.0003
Schistosoma mansoni ferritin light chain 0.0008 0.0046 0.0036
Loa Loa (eye worm) hypothetical protein 0.0027 0.0315 0.1089
Echinococcus granulosus intermediate filament protein 0.0028 0.0322 0.0315
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0147 0.0496
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0006 0.0013 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.06 0.0593
Loa Loa (eye worm) PXA domain-containing protein 0.001 0.0066 0.0208
Schistosoma mansoni lamin 0.0028 0.0322 0.0312
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0007
Brugia malayi hypothetical protein 0.001 0.0066 0.0211
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.043 0.042
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.055 0.0543
Brugia malayi MH1 domain containing protein 0.0009 0.0049 0.0151
Schistosoma mansoni steroid dehydrogenase 0.0006 0.0013 0.0002
Echinococcus granulosus lamin 0.0028 0.0322 0.0315
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0006 0.0013 0.5
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0147 0.0412
Echinococcus multilocularis conserved hypothetical protein 0.0006 0.0013 0.0005
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0006 0.0013 0.005
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.001 0.0066 0.0208
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0208
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0057 0.0146
Echinococcus multilocularis musashi 0.0028 0.0322 0.0315
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0009 0.0057 0.0146
Echinococcus multilocularis retinol dehydrogenase 13 0.0006 0.0013 0.0005
Trichomonas vaginalis chromobox protein, putative 0.0035 0.043 0.1304
Schistosoma mansoni steroid dehydrogenase 0.0006 0.0013 0.0002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.06 0.2102
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0006 0.0013 0.0005
Onchocerca volvulus 0.0006 0.0013 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0006 0.001 0.0191
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0006 0.0013 0.5
Echinococcus granulosus GPCR family 2 0.0016 0.0159 0.0151
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Entamoeba histolytica short chain dehydrogenase family protein 0.0006 0.0013 0.005
Schistosoma mansoni steroid dehydrogenase 0.0006 0.0013 0.0002
Echinococcus multilocularis carbonyl reductase 1 0.0006 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.0019
Onchocerca volvulus 0.0006 0.0013 0.0008
Brugia malayi PAN domain containing protein 0.0015 0.0147 0.0499
Onchocerca volvulus 0.0015 0.0147 0.0426
Toxoplasma gondii PAN domain-containing protein 0.024 0.3332 1
Entamoeba histolytica hypothetical protein 0.0038 0.0464 0.9292
Schistosoma mansoni cpg binding protein 0.0015 0.0147 0.0137
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0006 0.0013 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0348 0.0338
Schistosoma mansoni steroid dehydrogenase 0.0006 0.0013 0.0002
Echinococcus granulosus hypothetical protein 0.0006 0.0013 0.0005
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0006 0.0013 0.0005
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0006 0.0013 0.5
Echinococcus granulosus ferritin 0.0008 0.0046 0.0039
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0006 0.0013 0.5
Toxoplasma gondii carbonyl reductase 1, putative 0.0006 0.0013 0.0007
Schistosoma mansoni cpg binding protein 0.0015 0.0147 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0057 0.0146
Brugia malayi Dehydrogenases, short chain protein 2 0.0006 0.0013 0.0022
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0006 0.0013 0.5
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.001 0.0066 0.0208
Loa Loa (eye worm) hypothetical protein 0.0028 0.0322 0.1115
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Trypanosoma brucei short-chain dehydrogenase, putative 0.0006 0.0013 0.5
Onchocerca volvulus 0.0028 0.0322 0.0968
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.0013 0.0111 0.0367
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0426 0.1485
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0127 0.0364
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0147 0.0412
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0464 0.0457
Echinococcus granulosus steroid dehydrogenase 0.0006 0.0013 0.0005
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0049 0.0148
Echinococcus multilocularis microtubule associated protein 2 0.071 1 1
Onchocerca volvulus 0.0015 0.0147 0.0426
Schistosoma mansoni Smad4 0.0009 0.0049 0.0039
Onchocerca volvulus Sepiapterin reductase homolog 0.0006 0.0013 0.0008
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0006 0.0013 0.0007
Entamoeba histolytica hypothetical protein 0.0038 0.0464 0.9292
Loa Loa (eye worm) hypothetical protein 0.0015 0.0147 0.0496
Toxoplasma gondii PAN/Apple domain-containing protein 0.0015 0.0147 0.0412
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.001 0.0066 0.0059
Echinococcus multilocularis chromobox protein 2 0.0006 0.001 0.0003
Toxoplasma gondii microneme protein, putative 0.0015 0.0147 0.0412
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0013 0.5
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0046 0.0285
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0046 0.0285
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Schistosoma mansoni regulator of G protein signaling 0.001 0.0066 0.0056
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0046 0.0285
Trypanosoma cruzi short chain dehydrogenase, putative 0.0006 0.0013 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0006 0.0013 0.0235
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.2044 0.2035
Onchocerca volvulus 0.0015 0.0147 0.0426
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.0019
Toxoplasma gondii microneme protein MIC17A 0.0015 0.0147 0.0412
Schistosoma mansoni ferritin 0.0008 0.0046 0.0036
Loa Loa (eye worm) hypothetical protein 0.003 0.0348 0.1207
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0046 0.5
Onchocerca volvulus 0.0015 0.0147 0.0426
Plasmodium vivax heterochromatin protein 1, putative 0.0006 0.001 0.0191
Plasmodium vivax hypothetical protein, conserved 0.0006 0.001 0.0191
Brugia malayi MH2 domain containing protein 0.0125 0.1706 0.6025
Brugia malayi hypothetical protein 0.001 0.0066 0.0211
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0006 0.0013 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0006 0.0013 0.005
Brugia malayi CXXC zinc finger family protein 0.0015 0.0135 0.0455
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.001
Schistosoma mansoni smad 0.0009 0.0049 0.0039
Brugia malayi PAN domain containing protein 0.0015 0.0147 0.0499
Echinococcus multilocularis cpg binding protein 0.0015 0.0147 0.0139
Loa Loa (eye worm) hypothetical protein 0.0016 0.0149 0.0501
Onchocerca volvulus 0.0016 0.0149 0.043
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Loa Loa (eye worm) oxidoreductase 0.0006 0.0013 0.0019
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2827 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0032 0.0068
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0348 0.0341
Schistosoma mansoni steroid dehydrogenase 0.0006 0.0013 0.0002
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.001 0.0066 0.0174
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1706 0.6024
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0066 0.0208
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Onchocerca volvulus 0.0006 0.0013 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0147 0.0496
Brugia malayi regulator of G-protein signaling rgs-7 0.001 0.0066 0.0211
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0049 0.0042
Loa Loa (eye worm) oxidoreductase 0.0006 0.0013 0.0019
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0066 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0348 0.0338
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0348 0.1016
Schistosoma mansoni carbonyl reductase 0.0006 0.0013 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1706 0.6024
Onchocerca volvulus 0.0015 0.0147 0.0426
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0057 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0127 0.0364
Schistosoma mansoni hypothetical protein 0.0016 0.0159 0.0148
Brugia malayi Dehydrogenases, short chain protein 30 0.0006 0.0013 0.0022
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0006 0.0013 0.005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0159 0.0535
Brugia malayi Regulator of G protein signaling domain containing protein 0.001 0.0066 0.0211
Brugia malayi dehydrogenases, short chain protein 2 0.0006 0.0013 0.0022
Loa Loa (eye worm) dehydrogenase 0.0006 0.0013 0.0019
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0499 1
Echinococcus multilocularis smad 0.0009 0.0049 0.0042
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.055 0.1626
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Onchocerca volvulus 0.0015 0.0147 0.0426
Echinococcus multilocularis GPCR, family 2 0.0016 0.0159 0.0151
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.055 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0464 0.0454
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.0019
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0088 0.1184 0.4174
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0464 0.0457
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.0019
Schistosoma mansoni smad1 5 8 and 0.0009 0.0049 0.0039
Toxoplasma gondii subtilisin SUB12 0.0015 0.0147 0.0412
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0656 0.2302
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0006 0.0013 0.0002
Echinococcus granulosus hypothetical protein 0.0006 0.0013 0.0005
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0006 0.001 0.0003
Trypanosoma brucei short-chain dehydrogenase, putative 0.0006 0.0013 0.5
Echinococcus multilocularis tumor protein p63 0.0331 0.4627 0.4623
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.0019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0009 0.0057 0.0146
Echinococcus granulosus retinol dehydrogenase 11 0.0006 0.0013 0.0005
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0499 1
Echinococcus multilocularis regulator of G protein signaling 3 0.001 0.0066 0.0059
Echinococcus multilocularis axis inhibition protein axin 0.001 0.0066 0.0059
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.055 0.1626
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0049 0.0042
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0006 0.0013 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.06 0.059
Echinococcus granulosus smad 0.0009 0.0049 0.0042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0382 0.0372
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0118 0.0111
Echinococcus multilocularis retinol dehydrogenase 11 0.0006 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0147 0.0496
Onchocerca volvulus 0.0015 0.0147 0.0426
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0159 0.0151
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0139 0.0467
Loa Loa (eye worm) hypothetical protein 0.0035 0.0426 0.1483
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0006 0.0013 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0006 0.0013 0.5
Onchocerca volvulus 0.0015 0.0147 0.0426
Brugia malayi Pre-SET motif family protein 0.003 0.0348 0.121
Schistosoma mansoni hypothetical protein 0.0016 0.0159 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0066 0.0174
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0159 0.0535
Echinococcus granulosus regulator of G protein signaling 3 0.001 0.0066 0.0059
Echinococcus granulosus chromobox protein 1 0.0035 0.043 0.0423
Brugia malayi PAN domain containing protein 0.0015 0.0147 0.0499
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0088 0.1184 0.1177
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0006 0.0013 0.5
Brugia malayi PAN domain containing protein 0.0015 0.0147 0.0499
Schistosoma mansoni apoferritin-2 0.0008 0.0046 0.0036
Echinococcus granulosus oxidoreductase 0.0006 0.0013 0.0005
Echinococcus granulosus expressed protein 0.0008 0.0046 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0066 0.0056
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0006 0.0013 0.0019
Schistosoma mansoni apoferritin-2 0.0008 0.0046 0.0036
Onchocerca volvulus 0.0006 0.0013 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0013 0.5
Echinococcus multilocularis lamin 0.0028 0.0322 0.0315
Echinococcus multilocularis steroid dehydrogenase 0.0006 0.0013 0.0005
Onchocerca volvulus 0.0006 0.0013 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.002 0.021 0.0619
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0006 0.0013 0.0008
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Echinococcus granulosus carbonyl reductase 1 0.0006 0.0013 0.0005
Entamoeba histolytica hypothetical protein, conserved 0.0006 0.0013 0.005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0147 0.0496
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0006 0.0013 0.0007
Echinococcus granulosus carbonyl reductase 1 0.0006 0.0013 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0088 0.1184 1
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0147 0.0496
Toxoplasma gondii hypothetical protein 0.0015 0.0147 0.0412
Onchocerca volvulus 0.0015 0.0147 0.0426
Loa Loa (eye worm) oxidoreductase 0.0006 0.0013 0.0019
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0006 0.0013 0.005
Onchocerca volvulus 0.0006 0.0013 0.0008
Toxoplasma gondii microneme protein MIC4 0.0015 0.0147 0.0412
Echinococcus granulosus Chromo domain 0.0006 0.001 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0656 0.2302
Schistosoma mansoni regulator of G protein signaling 0.001 0.0066 0.0056
Schistosoma mansoni smad1 5 8 and 0.0009 0.0049 0.0039
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0035 0.0426 0.0416
Onchocerca volvulus 0.0006 0.0013 0.0008
Onchocerca volvulus 0.0006 0.0013 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0208
Entamoeba histolytica hypothetical protein 0.001 0.0066 0.1146
Loa Loa (eye worm) CHromoDomain protein family member 0.0007 0.0022 0.0052
Loa Loa (eye worm) hypothetical protein 0.0013 0.0111 0.0367
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.001 0.0066 0.0056
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0006 0.0013 0.005
Loa Loa (eye worm) RGS-3 protein 0.001 0.0066 0.0208
Brugia malayi Pre-SET motif family protein 0.0204 0.2827 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0006 0.0013 0.0008
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0013 0.0022
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0322 0.1115
Brugia malayi PAN domain containing protein 0.0015 0.0147 0.0499
Echinococcus granulosus chromobox protein 1 0.0035 0.043 0.0423
Schistosoma mansoni chromobox protein 0.0035 0.043 0.042
Schistosoma mansoni ferritin light chain 0.0008 0.0046 0.0036
Schistosoma mansoni smad1 5 8 and 0.0009 0.0049 0.0039
Brugia malayi Retinol dehydrogenase 12 0.0006 0.0013 0.0022
Schistosoma mansoni short chain dehydrogenase 0.0006 0.0013 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0348 0.0341
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0208
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0656 0.2299
Loa Loa (eye worm) hypothetical protein 0.0051 0.0656 0.2299
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0208
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0006 0.0013 0.0005

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -4.7 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = -3.55 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = -0.53 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 2 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 32 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 98 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 99 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 1.67 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 2 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 32 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 98 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 99 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.01 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.96797 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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