Detailed information for compound 646867

Basic information

Technical information
  • TDR Targets ID: 646867
  • Name: ethyl 4-[3-[[1-(furan-2-ylmethyl)-2,4,6-triox o-1,3-diazinan-5-ylidene]methyl]-2,5-dimethyl pyrrol-1-yl]benzoate
  • MW: 461.467 | Formula: C25H23N3O6
  • H donors: 1 H acceptors: 4 LogP: 3.16 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)n1c(C)cc(c1C)/C=C\1/C(=O)NC(=O)N(C1=O)Cc1ccco1
  • InChi: 1S/C25H23N3O6/c1-4-33-24(31)17-7-9-19(10-8-17)28-15(2)12-18(16(28)3)13-21-22(29)26-25(32)27(23(21)30)14-20-6-5-11-34-20/h5-13H,4,14H2,1-3H3,(H,26,29,32)/b21-13-
  • InChiKey: XLXSVYHQWFFRHB-BKUYFWCQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-[3-[(Z)-[1-(furan-2-ylmethyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-2,5-dimethylpyrrol-1-yl]benzoate
  • ethyl 4-[3-[[1-(2-furylmethyl)-2,4,6-trioxo-hexahydropyrimidin-5-ylidene]methyl]-2,5-dimethyl-pyrrol-1-yl]benzoate
  • ethyl 4-[3-[(Z)-[1-(2-furylmethyl)-2,4,6-trioxo-hexahydropyrimidin-5-ylidene]methyl]-2,5-dimethyl-pyrrol-1-yl]benzoate
  • 4-[3-[[1-(2-furylmethyl)-2,4,6-trioxo-5-hexahydropyrimidinylidene]methyl]-2,5-dimethyl-1-pyrrolyl]benzoic acid ethyl ester
  • 4-[3-[(Z)-[1-(2-furylmethyl)-2,4,6-trioxo-5-hexahydropyrimidinylidene]methyl]-2,5-dimethyl-1-pyrrolyl]benzoic acid ethyl ester
  • 4-[3-[[1-(2-furylmethyl)-2,4,6-triketo-hexahydropyrimidin-5-ylidene]methyl]-2,5-dimethyl-pyrrol-1-yl]benzoic acid ethyl ester
  • 4-[3-[(Z)-[1-(2-furylmethyl)-2,4,6-triketo-hexahydropyrimidin-5-ylidene]methyl]-2,5-dimethyl-pyrrol-1-yl]benzoic acid ethyl ester
  • ethyl 4-[3-[(Z)-[1-(furan-2-ylmethyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-2,5-dimethyl-pyrrol-1-yl]benzoate
  • ethyl 4-[3-[[1-(furan-2-ylmethyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-2,5-dimethyl-pyrrol-1-yl]benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans lipase LipD 0.0156 0.1029 0.4171
Brugia malayi hypothetical protein 0.0093 0.0554 0.0729
Brugia malayi Probable DNA topoisomerase II 0.0028 0.0065 0.0085
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.0818 0.0993
Loa Loa (eye worm) hypothetical protein 0.004 0.0151 0.0199
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0018 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0414 0.0846
Onchocerca volvulus Huntingtin homolog 0.0275 0.1934 0.2738
Schistosoma mansoni hypothetical protein 0.007 0.0376 0.0452
Schistosoma mansoni polycystin 1-related 0.024 0.1664 0.203
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0047 0.0206 0.0271
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.03 0.0612
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0028 0.0065 0.012
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0282 0.0337
Schistosoma mansoni thyroid hormone receptor 0.0047 0.0206 0.0244
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0356 0.0468
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0271
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0151 0.0144
Schistosoma mansoni Smad4 0.0031 0.0085 0.0096
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0148 0.0969 0.2006
Echinococcus granulosus geminin 0.1099 0.8171 0.817
Mycobacterium tuberculosis Probable esterase LipL 0.0156 0.1029 0.1385
Onchocerca volvulus Matrix metalloproteinase homolog 0.0647 0.4746 0.6719
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0333 0.2371 0.2895
Trichomonas vaginalis receptor histidine kinase, putative 0.0028 0.0065 0.012
Loa Loa (eye worm) hypothetical protein 0.0148 0.0967 0.1272
Brugia malayi hypothetical protein 0.0148 0.0967 0.1272
Loa Loa (eye worm) hypothetical protein 0.062 0.454 0.5975
Plasmodium vivax heat shock protein, putative 0.0399 0.2873 1
Onchocerca volvulus 0.0156 0.1029 0.1457
Trypanosoma cruzi heat shock protein 85, putative 0.014 0.0907 0.1878
Echinococcus granulosus Niemann Pick C1 protein 0.0328 0.2332 0.2327
Brugia malayi Matrixin family protein 0.1007 0.7477 0.9841
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0028 0.0065 0.0226
Schistosoma mansoni cellular tumor antigen P53 0.0111 0.0691 0.0838
Schistosoma mansoni smad1 5 8 and 0.007 0.0377 0.0454
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Giardia lamblia Kinase, CMGC MAPK 0.006 0.03 0.0609
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.0085 0.0111
Loa Loa (eye worm) hypothetical protein 0.0042 0.0168 0.0221
Loa Loa (eye worm) hypothetical protein 0.005 0.0229 0.0302
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0085 0.0162
Schistosoma mansoni DNA topoisomerase II 0.0028 0.0065 0.0071
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0356 0.0427
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.0367 0.036
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0356 0.0468
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0414 0.0846
Loa Loa (eye worm) hypothetical protein 0.0111 0.0691 0.0909
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0356 0.0427
Plasmodium falciparum thioredoxin reductase 0.009 0.0528 0.1838
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0018 0.0023
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0227 0.157 0.2118
Trypanosoma cruzi hypothetical protein, conserved 0.0156 0.1029 0.2132
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0085 0.0162
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0156 0.1027 0.1021
Trypanosoma cruzi hypothetical protein, conserved 0.0156 0.1029 0.2132
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0151 0.0301
Plasmodium vivax JmjC domain containing protein 0.0033 0.0099 0.0345
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0099 0.013
Mycobacterium ulcerans DNA gyrase subunit B 0.0028 0.0065 0.0236
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0144 0.0943 0.1953
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0282 0.0275
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0321 0.2278 0.3078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0206 0.0199
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0144 0.0943 0.1953
Trypanosoma brucei heat shock protein, putative 0.0168 0.1123 0.2327
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0151 0.0144
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0151 0.0177
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0085 0.0162
Brugia malayi jmjC domain containing protein 0.0033 0.0099 0.013
Trypanosoma cruzi heat shock protein, putative 0.0094 0.056 0.1153
Loa Loa (eye worm) MH2 domain-containing protein 0.1023 0.7598 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0124 0.0786 0.0779
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0271
Onchocerca volvulus 0.0156 0.1029 0.1457
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.174 0.229
Onchocerca volvulus Protein ultraspiracle homolog 0.0047 0.0206 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0047 0.0206 0.0271
Brugia malayi nuclear receptor NHR-67 0.0022 0.0018 0.0023
Schistosoma mansoni transcription factor btf3 0.0075 0.0414 0.0499
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0028 0.0065 0.0092
Schistosoma mansoni hypothetical protein 0.0136 0.0877 0.1065
Plasmodium vivax DNA gyrase subunit B, putative 0.0028 0.0065 0.0226
Brugia malayi MAP kinase sur-1 0.006 0.03 0.0395
Schistosoma mansoni nuclear receptor 0.0022 0.0018 0.0013
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0151 0.0301
Loa Loa (eye worm) endoplasmin 0.0168 0.1123 0.1477
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0031 0.0085 0.0317
Brugia malayi Calcitonin receptor-like protein seb-1 0.022 0.1515 0.1994
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.1377 0.1371
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0151 0.0199
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.008 0.0073
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Trichomonas vaginalis sensor histidine kinase, putative 0.0028 0.0065 0.012
Onchocerca volvulus 0.0091 0.0535 0.0757
Brugia malayi Hemopexin family protein 0.0388 0.2787 0.3667
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0099 0.013
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0333 0.2372 0.3122
Plasmodium vivax hypothetical protein, conserved 0.0156 0.1029 0.3582
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0031 0.0085 0.0121
Echinococcus granulosus heat shock protein 90 0.0168 0.1123 0.1116
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0028 0.0065 0.0121
Mycobacterium leprae PROBABLE HYDROLASE 0.0333 0.2372 1
Brugia malayi jmjC domain containing protein 0.0033 0.0099 0.013
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0099 0.0192
Trichomonas vaginalis CMGC family protein kinase 0.006 0.03 0.0609
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0206 0.0199
Trypanosoma brucei heat shock protein 90, putative 0.0168 0.1123 0.2327
Echinococcus multilocularis mothers against decapentaplegic 2 0.0031 0.0085 0.0078
Echinococcus multilocularis mothers against decapentaplegic 5 0.007 0.0377 0.0371
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0047 0.0206 0.0271
Trypanosoma brucei transcription factor BTF3, putative 0.0075 0.0414 0.085
Loa Loa (eye worm) PHD-finger family protein 0.0046 0.0196 0.0259
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0031 0.0085 0.0294
Plasmodium falciparum DNA topoisomerase 2 0.0028 0.0065 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0356 0.0427
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.03 0.0612
Trichomonas vaginalis CMGC family protein kinase 0.006 0.03 0.0609
Loa Loa (eye worm) hypothetical protein 0.0156 0.1029 0.1355
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0031 0.0085 0.0294
Mycobacterium ulcerans putative regultory protein 0.0028 0.0065 0.0236
Brugia malayi nuclear receptor NHR-88 0.0047 0.0206 0.0271
Echinococcus multilocularis protein dispatched 1 0.0161 0.1066 0.1059
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0018 0.0013
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0229 0.0273
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0028 0.0065 0.0236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0657 0.4822 1
Onchocerca volvulus 0.0091 0.0535 0.0757
Echinococcus granulosus tar DNA binding protein 0.0067 0.0356 0.0349
Trypanosoma cruzi heat shock protein 85, putative 0.0168 0.1123 0.2327
Trichomonas vaginalis D-aminoacylase, putative 0.0156 0.1029 0.2123
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.0376 0.037
Loa Loa (eye worm) hypothetical protein 0.015 0.0988 0.13
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.011 0.0682 0.0897
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.1012 0.1231
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0156 0.1027 0.1021
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0151 0.0144
Brugia malayi jmjC domain containing protein 0.0033 0.0099 0.013
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.0085 0.0026
Onchocerca volvulus 0.0242 0.1682 0.2381
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.1012 0.1231
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0321 0.2278 0.9269
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0356 0.0427
Trichomonas vaginalis heat shock protein, putative 0.0086 0.0498 0.102
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0036 0.0122 0.0425
Brugia malayi glutathione reductase 0.009 0.0528 0.0695
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.0099 0.0113
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0028 0.0065 0.0078
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0028 0.0065 0.0078
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0122 0.0115
Loa Loa (eye worm) hypothetical protein 0.0157 0.1039 0.1367
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0227 0.157 0.2118
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0156 0.1029 0.1385
Loa Loa (eye worm) MH2 domain-containing protein 0.007 0.0377 0.0497
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0282 0.0275
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0047 0.0206 0.0244
Brugia malayi beta-NAC-like protein 0.0075 0.0414 0.0545
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0367 0.0441
Loa Loa (eye worm) hypothetical protein 0.0028 0.0065 0.0085
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0229 0.0302
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0657 0.4822 1
Schistosoma mansoni intermediate filament proteins 0.0091 0.0535 0.0647
Echinococcus multilocularis lamin 0.0091 0.0535 0.0528
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0047 0.0206 0.0244
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0018 0.0025
Echinococcus granulosus phd:f box containing protein 0.0033 0.0099 0.0092
Schistosoma mansoni jumonji domain containing protein 0.0124 0.0786 0.0954
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0156 0.1029 0.1252
Entamoeba histolytica hypothetical protein 0.0156 0.1027 0.2119
Trypanosoma brucei hypothetical protein, conserved 0.0156 0.1029 0.2132
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0047 0.0206 0.0271
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0151 0.03
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0031 0.0085 1
Toxoplasma gondii NAC domain-containing protein 0.0075 0.0414 0.1442
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0018 0.0011
Echinococcus multilocularis ecdysone induced protein 78C 0.0047 0.0206 0.0199
Schistosoma mansoni endoplasmin 0.0168 0.1123 0.1366
Brugia malayi Endoplasmin precursor 0.0168 0.1123 0.1477
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0018 0.0013
Entamoeba histolytica hypothetical protein 0.0156 0.1027 0.2119
Brugia malayi Bromodomain containing protein 0.0085 0.0494 0.065
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0413 0.2978 0.2973
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0007 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0047 0.0206 0.0271
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0156 0.1029 0.4171
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Loa Loa (eye worm) hypothetical protein 0.0044 0.018 0.0237
Mycobacterium tuberculosis Conserved protein 0.0156 0.1029 0.1385
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0154 0.1012 0.1006
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0148 0.0969 0.3916
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.03 0.0612
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0031 0.0085 0.0294
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0122 0.0425
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Brugia malayi Pre-SET motif family protein 0.0213 0.1459 0.1921
Schistosoma mansoni lipoxygenase 0.0148 0.0967 0.1176
Plasmodium vivax endoplasmin, putative 0.0168 0.1123 0.3907
Echinococcus multilocularis fetal alzheimer antigen, falz 0.005 0.0229 0.0222
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.0085 0.0095
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0028 0.0065 0.0078
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0038 0.005
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0211 0.1446 0.1763
Brugia malayi conserved hypotetical protein 0.0022 0.0018 0.0023
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0144 0.0943 0.0937
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0122 0.0115
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0037 0.0131 0.0124
Loa Loa (eye worm) jmjC domain-containing protein 0.0128 0.0818 0.1077
Trichomonas vaginalis penicillin-binding protein, putative 0.0156 0.1029 0.2123
Trichomonas vaginalis CMGC family protein kinase 0.006 0.03 0.0609
Trypanosoma brucei heat shock protein 84, putative 0.0094 0.056 0.1153
Echinococcus granulosus zinc finger protein 0.0043 0.0179 0.0172
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0229 0.0273
Loa Loa (eye worm) hypothetical protein 0.0057 0.0282 0.0371
Echinococcus granulosus sterol regulatory element binding protein 0.0141 0.0915 0.0909
Plasmodium falciparum heat shock protein 90 0.0168 0.1123 0.3907
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0018 0.0023
Loa Loa (eye worm) MH1 domain-containing protein 0.007 0.0377 0.0497
Loa Loa (eye worm) TOPoisomerase family member 0.0028 0.0065 0.0085
Schistosoma mansoni hypothetical protein 0.0148 0.0967 0.1176
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.0099 0.0092
Schistosoma mansoni smad 0.0031 0.0085 0.0096
Loa Loa (eye worm) hypothetical protein 0.0503 0.366 0.4818
Trypanosoma cruzi DNA topoisomerase II, putative 0.0028 0.0065 0.0121
Echinococcus multilocularis isocitrate dehydrogenase 0.0036 0.0122 0.0115
Schistosoma mansoni coup transcription factor 0.0047 0.0206 0.0244
Loa Loa (eye worm) hypothetical protein 0.0275 0.1934 0.2545
Loa Loa (eye worm) hypothetical protein 0.0095 0.0567 0.0746
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0047 0.0206 0.0199
Brugia malayi steroid hormone receptor 0.0047 0.0206 0.0271
Onchocerca volvulus 0.011 0.0682 0.0965
Mycobacterium leprae conserved hypothetical protein 0.0156 0.1029 0.4179
Loa Loa (eye worm) heat shock protein 75 0.0094 0.056 0.0736
Schistosoma mansoni retinoic acid receptor RXR 0.0047 0.0206 0.0244
Brugia malayi N-terminal motif family protein 0.02 0.1366 0.1798
Echinococcus granulosus transcription factor btf3 0.0075 0.0414 0.0408
Schistosoma mansoni rab6-interacting 0.0148 0.0967 0.1176
Entamoeba histolytica hypothetical protein 0.0156 0.1027 0.2119
Brugia malayi RNA binding protein 0.0067 0.0356 0.0468
Echinococcus multilocularis mothers against decapentaplegic 6 0.0031 0.0085 0.0078
Trypanosoma brucei heat shock protein, putative 0.0168 0.1123 0.2327
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.0085 0.0162
Trichomonas vaginalis glutathione reductase, putative 0.0031 0.0085 0.0161
Trypanosoma brucei Heat shock protein 83, putative 0.0168 0.1123 0.2327
Schistosoma mansoni Smad4 0.007 0.0377 0.0454
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0654 0.4801 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0018 0.0023
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0036 0.0122 0.0115
Trichomonas vaginalis heat shock protein, putative 0.014 0.0907 0.1869
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0206 0.0199
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0154 0.1012 0.1332
Trichomonas vaginalis endoplasmin, putative 0.0114 0.0714 0.1467
Echinococcus granulosus TGF beta signal transducer SmadC 0.007 0.0377 0.0371
Loa Loa (eye worm) hypothetical protein 0.0156 0.1029 0.1355
Mycobacterium tuberculosis Probable oxidoreductase 0.0227 0.157 0.2118
Brugia malayi ecdysone receptor 0.0022 0.0018 0.0023
Onchocerca volvulus 0.0031 0.008 0.0114
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0147 0.0193
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.007 0.0376 0.0495
Echinococcus granulosus lysine specific demethylase 5A 0.0128 0.0818 0.0812
Loa Loa (eye worm) thioredoxin reductase 0.009 0.0528 0.0695
Leishmania major trypanothione reductase 0.009 0.0528 0.1087
Plasmodium falciparum thioredoxin reductase 0.0031 0.0085 0.0294
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0092 0.0546 0.1124
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0099 0.013
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0036 0.0122 0.0141
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0028 0.0065 0.0121
Loa Loa (eye worm) hypothetical protein 0.0089 0.0522 0.0687
Mycobacterium tuberculosis Probable two component sensor kinase 0.0028 0.0065 0.0078
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0038 0.0136 0.0129
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0028 0.0065 0.0236
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0028 0.0065 0.0226
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.0099 0.0092
Leishmania major mitochondrial DNA polymerase beta 0.0654 0.4801 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0151 0.0301
Trypanosoma brucei heat shock protein, putative 0.0168 0.1123 0.2327
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0206 0.0199
Brugia malayi MH1 domain containing protein 0.007 0.0377 0.0497
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0206 0.0244
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0144 0.0943 0.1944
Entamoeba histolytica hypothetical protein 0.0075 0.0414 0.0846
Trypanosoma cruzi ISWI complex protein 0.0034 0.0107 0.0208
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0028 0.0065 0.0236
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.0099 0.0092
Entamoeba histolytica heat shock protein 90, putative 0.0168 0.1123 0.2317
Echinococcus multilocularis Smad4 0.007 0.0377 0.0371
Treponema pallidum NADH oxidase 0.0031 0.0085 0.0041
Schistosoma mansoni hypothetical protein 0.011 0.0682 0.0826
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0227 0.157 0.6524
Echinococcus granulosus beta LACTamase domain containing family member 0.0156 0.1029 0.1023
Brugia malayi hypothetical protein 0.0022 0.0018 0.0023
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.0038 0.005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.022 0.1515 0.1994
Echinococcus multilocularis survival motor neuron protein 1 0.0539 0.3929 0.3925
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0047 0.0206 0.0199
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 0.1366 0.1935
Loa Loa (eye worm) beta-lactamase 0.0156 0.1029 0.1355
Schistosoma mansoni heat shock protein 0.0168 0.1123 0.1366
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0028 0.0065 0.0078
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.03 0.0294
Echinococcus granulosus lipoxygenase domain containing protein 0.0148 0.0967 0.096
Loa Loa (eye worm) isocitrate dehydrogenase 0.0036 0.0122 0.0161
Trypanosoma brucei developmentally regulated phosphoprotein 0.0028 0.0065 0.0121
Echinococcus multilocularis transcription factor Dp 1 0.0084 0.0482 0.0476
Schistosoma mansoni heat shock protein 0.0168 0.1123 0.1366
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.062 0.454 0.5552
Schistosoma mansoni hypothetical protein 0.0388 0.2787 0.3404
Schistosoma mansoni protein phosphatase 2C 0.0033 0.0099 0.0113
Onchocerca volvulus Matrilysin homolog 0.0313 0.2223 0.3147
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.0099 0.0092
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0124 0.0786 0.0779
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0356 0.0427
Onchocerca volvulus 0.0388 0.2787 0.3945
Brugia malayi nuclear receptor RXR 0.0022 0.0018 0.0023
Schistosoma mansoni hypothetical protein 0.015 0.0988 0.1201
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0206 0.0271
Echinococcus granulosus expressed conserved protein 0.0308 0.2182 0.2176
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.03 0.0294
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0141 0.0915 0.1204
Schistosoma mansoni bromodomain containing protein 0.0141 0.0914 0.1111
Echinococcus multilocularis protein patched 0.0141 0.0915 0.0909
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0028 0.0065 0.0085
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0154 0.1012 0.1332
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0085 0.0162
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.008 0.0454 0.0447
Echinococcus granulosus thioredoxin glutathione reductase 0.009 0.0532 0.0525
Brugia malayi CHE-14 protein 0.0141 0.0915 0.1204
Echinococcus granulosus intermediate filament protein 0.0091 0.0535 0.0528
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.005
Schistosoma mansoni jumonji domain containing protein 0.0033 0.0099 0.0113
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0047 0.0206 0.0199
Brugia malayi mbt repeat family protein 0.005 0.0229 0.0302
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.008 0.009
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0028 0.0065 0.0121
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0038 0.0038
Brugia malayi MH2 domain containing protein 0.007 0.0377 0.0497
Brugia malayi Steroid receptor seven-up type 2 0.0047 0.0206 0.0271
Echinococcus granulosus endoplasmin 0.0148 0.0969 0.0962
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0094 0.056 0.0792
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.0376 0.037
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.008 0.0454 0.0447
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.03 0.0294
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0072 0.0065
Trypanosoma brucei heat shock protein, putative 0.0168 0.1123 0.2327
Echinococcus multilocularis beta LACTamase domain containing family member 0.0156 0.1029 0.1023
Echinococcus multilocularis GPCR, family 2 0.007 0.0376 0.037
Trichomonas vaginalis heat shock protein, putative 0.0114 0.0714 0.1467
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0154 0.1012 0.1006
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.0367 0.036
Entamoeba histolytica hypothetical protein 0.0156 0.1027 0.2119
Schistosoma mansoni rab6-interacting 0.0148 0.0967 0.1176
Trypanosoma cruzi transcription factor btf3, putative 0.0075 0.0414 0.085
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0028 0.0065 0.0092
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0282 0.0275
Echinococcus multilocularis lipoxygenase domain containing protein 0.0148 0.0967 0.096
Loa Loa (eye worm) hypothetical protein 0.0313 0.2223 0.2925
Brugia malayi nuclear receptor RXR 0.0025 0.0038 0.005
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0036 0.0122 0.0425
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0085 0.0162
Trypanosoma brucei heat shock protein 90, putative 0.0168 0.1123 0.2327
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0047 0.0206 0.0244
Schistosoma mansoni hypothetical protein 0.007 0.0376 0.0452
Echinococcus multilocularis Niemann Pick C1 protein 0.0328 0.2332 0.2327
Schistosoma mansoni smad 0.007 0.0377 0.0454
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Onchocerca volvulus 0.0022 0.0018 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0657 0.4822 1
Entamoeba histolytica DNA topoisomerase II, putative 0.0028 0.0065 0.012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0085 0.0162
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0031 0.0085 0.0317
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0028 0.0065 0.0058
Schistosoma mansoni loxhd1 0.0148 0.0967 0.1176
Brugia malayi latrophilin 2 splice variant baaae 0.015 0.0988 0.13
Brugia malayi Isocitrate dehydrogenase 0.0036 0.0122 0.0161
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0068 0.0367 0.0483
Echinococcus granulosus transcription factor Dp 1 0.0084 0.0482 0.0476
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0028 0.0065 0.0078
Echinococcus multilocularis heat shock protein 0.0168 0.1123 0.1116
Onchocerca volvulus 0.0148 0.0967 0.1369
Mycobacterium ulcerans hypothetical protein 0.0344 0.2458 1
Echinococcus granulosus Niemann Pick C1 protein 0.0469 0.3398 0.3393
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.0376 0.0495
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0133 0.0853 0.0847
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Brugia malayi nuclear hormone receptor 0.0047 0.0206 0.0271
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0028 0.0065 0.012
Brugia malayi Smad1 0.007 0.0377 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0047 0.0206 0.0271
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Mycobacterium ulcerans two component regulator - sensor kinase 0.0028 0.0065 0.0236
Loa Loa (eye worm) hypothetical protein 0.0148 0.0967 0.1272
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0085 0.0162
Brugia malayi intermediate filament protein 0.0091 0.0535 0.0704
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0036 0.0122 0.0156
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0321 0.2278 0.9593
Mycobacterium tuberculosis Probable hydrolase 0.0156 0.1029 0.1385
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0148 0.0969 0.1303
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Schistosoma mansoni methyl-cpg binding protein mbd 0.0038 0.0136 0.0158
Schistosoma mansoni smad1 5 8 and 0.007 0.0377 0.0454
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0229 0.0223
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0047 0.0206 0.0199
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0028 0.0065 0.0078
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0031 0.0085 0.0317
Loa Loa (eye worm) hypothetical protein 0.0093 0.0554 0.0729
Echinococcus multilocularis sterol regulatory element binding protein 0.0141 0.0915 0.0909
Brugia malayi beta-lactamase family protein 0.0156 0.1029 0.1355
Trypanosoma cruzi trypanothione reductase, putative 0.009 0.0528 0.1087
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0028 0.0065 0.0236
Brugia malayi Latrophilin receptor protein 2 0.007 0.0376 0.0495
Trypanosoma brucei heat shock protein, putative 0.0168 0.1123 0.2327
Plasmodium vivax heat shock protein 90, putative 0.0094 0.056 0.1947
Toxoplasma gondii hypothetical protein 0.0105 0.0648 0.2255
Loa Loa (eye worm) matrixin family protein 0.1007 0.7477 0.9841
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0044 0.018 0.0173
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.0085 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0206 0.0271
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0414 0.0846
Plasmodium vivax multidomain scavenger receptor, putative 0.0148 0.0967 0.3365
Mycobacterium tuberculosis Possible two component sensor kinase 0.0028 0.0065 0.0078
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0036 0.0122 0.0115
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Schistosoma mansoni Smad4 0.0031 0.0085 0.0096
Schistosoma mansoni hypothetical protein 0.007 0.0376 0.0452
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0271
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0156 0.1029 0.1385
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0367 0.0441
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.005
Echinococcus multilocularis zinc finger protein 0.0043 0.0179 0.0172
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0028 0.0065 0.012
Entamoeba histolytica heat shock protein 90, putative 0.0168 0.1123 0.2317
Brugia malayi ecdysteroid receptor 0.0047 0.0206 0.0271
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.0038 0.0038
Onchocerca volvulus 0.005 0.0229 0.0325
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0156 0.1029 0.1385
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0151 0.03
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0204 0.1397 0.5775
Treponema pallidum fructose-bisphosphate aldolase 0.0657 0.4822 1
Echinococcus granulosus ecdysone induced protein 78C 0.0047 0.0206 0.0199
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0018 0.0011
Echinococcus granulosus RUN 0.0148 0.0967 0.096
Echinococcus multilocularis phd:f box containing protein 0.0033 0.0099 0.0092
Echinococcus multilocularis heat shock protein 90 0.014 0.0907 0.0901
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0271
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0085 0.0162
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0151 0.0177
Loa Loa (eye worm) hypothetical protein 0.0539 0.3929 0.5171
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0028 0.0065 0.0121
Schistosoma mansoni heat shock protein 0.0094 0.056 0.0677
Toxoplasma gondii DNA topoisomerase 2, putative 0.0028 0.0065 0.0226
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0036 0.0122 0.024
Loa Loa (eye worm) glutathione reductase 0.009 0.0528 0.0695
Schistosoma mansoni hypothetical protein 0.0136 0.0877 0.1065
Trichomonas vaginalis D-aminoacylase, putative 0.0156 0.1029 0.2123
Loa Loa (eye worm) MH1 domain-containing protein 0.0031 0.0085 0.0112
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Toxoplasma gondii heat shock protein 75, putative 0.0094 0.056 0.1947
Echinococcus multilocularis endoplasmin 0.0148 0.0969 0.0962
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0018 0.0023
Echinococcus granulosus FTZ F1 alpha 0.0047 0.0206 0.0199
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0156 0.1029 0.1355
Loa Loa (eye worm) hypothetical protein 0.0156 0.1029 0.1355
Brugia malayi cytoplasmic intermediate filament protein 0.0048 0.0217 0.0285
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0047 0.0206 0.0244
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.0038 0.0031
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0144 0.0943 0.1241
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0028 0.0065 0.0236
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0229 0.0325
Brugia malayi Pre-SET motif family protein 0.0031 0.008 0.0106
Echinococcus granulosus mothers against decapentaplegic 2 0.0031 0.0085 0.0078
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0206 0.0244
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0099 0.0345
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0047 0.0206 0.0199
Schistosoma mansoni RAR-like nuclear receptor 0.0047 0.0206 0.0244
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0018 0.0013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0047 0.0206 0.0291
Schistosoma mansoni hypothetical protein 0.0034 0.0107 0.0122
Schistosoma mansoni eyes absent homolog 0.0093 0.0554 0.067
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0028 0.0065 0.0092
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0094 0.056 0.1148
Brugia malayi Doublecortin family protein 0.0148 0.0967 0.1272
Plasmodium falciparum LCCL domain-containing protein 0.0148 0.0967 0.3365
Loa Loa (eye worm) MH2 domain-containing protein 0.0031 0.0085 0.0112
Trypanosoma brucei trypanothione reductase 0.009 0.0528 0.1087
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Echinococcus multilocularis thioredoxin glutathione reductase 0.009 0.0532 0.0525
Brugia malayi nuclear receptor NHR-88 0.0022 0.0018 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0206 0.0271
Mycobacterium ulcerans two component sensor kinase MprB 0.0028 0.0065 0.0236
Brugia malayi Thioredoxin reductase 0.009 0.0528 0.0695
Echinococcus granulosus mitogen activated protein kinase 0.006 0.03 0.0294
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0151 0.03
Mycobacterium ulcerans beta-lactamase 0.0156 0.1029 0.4171
Schistosoma mansoni serine/threonine protein kinase 0.006 0.03 0.0359
Echinococcus multilocularis TGF beta signal transducer SmadC 0.007 0.0377 0.0371
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0654 0.4801 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0047 0.0206 0.0271
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Echinococcus multilocularis Niemann Pick C1 protein 0.0469 0.3398 0.3393
Plasmodium falciparum endoplasmin, putative 0.0114 0.0714 0.2483
Onchocerca volvulus Huntingtin homolog 0.0275 0.1934 0.2738
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0028 0.0065 0.0078
Brugia malayi follicle stimulating hormone receptor 0.025 0.174 0.229
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0204 0.1397 0.1884
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0018 0.0011
Trypanosoma brucei heat shock protein, putative 0.0168 0.1123 0.2327
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0028 0.0065 0.0058
Schistosoma mansoni hypothetical protein 0.0046 0.0196 0.0232
Leishmania major hypothetical protein, conserved 0.0028 0.0065 0.0121
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0048 0.0217 0.0285
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0018 0.0011
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0044 0.018 0.0173
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0328 0.2332 0.483
Plasmodium falciparum heat shock protein 90, putative 0.0086 0.0498 0.1734
Plasmodium falciparum glutathione reductase 0.009 0.0528 0.1838
Loa Loa (eye worm) DR-78 0.0022 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0186
Echinococcus granulosus lamin 0.0091 0.0535 0.0528
Leishmania major hypothetical protein, conserved 0.0033 0.0099 0.0192
Brugia malayi Matrixin family protein 0.0313 0.2223 0.2925
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0151 0.03
Echinococcus granulosus GPCR family 2 0.007 0.0376 0.037
Trichomonas vaginalis CMGC family protein kinase 0.006 0.03 0.0609
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0122 0.024
Loa Loa (eye worm) intermediate filament protein 0.0091 0.0535 0.0704
Plasmodium falciparum heat shock protein 90, putative 0.0399 0.2873 1
Schistosoma mansoni hypothetical protein 0.1099 0.8171 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0148 0.0967 0.096
Onchocerca volvulus 0.0148 0.0967 0.1369
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0018 0.0011
Plasmodium vivax basic transcription factor 3b, putative 0.0075 0.0414 0.1442
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.0099 0.0345
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0271
Loa Loa (eye worm) hypothetical protein 0.0141 0.0915 0.1204
Mycobacterium ulcerans esterase/lipase LipP 0.0156 0.1029 0.4171
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0156 0.1029 0.1355
Loa Loa (eye worm) hypothetical protein 0.0093 0.0554 0.0729
Trichomonas vaginalis esterase, putative 0.0156 0.1029 0.2123
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0948 0.7026 0.7024
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0028 0.0065 0.0236
Leishmania major mitochondrial DNA topoisomerase II 0.0028 0.0065 0.0121
Loa Loa (eye worm) ICD-1 protein 0.0075 0.0414 0.0545
Trypanosoma brucei ISWI complex protein 0.0034 0.0107 0.0208
Leishmania major hypothetical protein, conserved 0.0034 0.0107 0.0208
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0085 0.0162
Echinococcus granulosus tumor protein p63 0.0759 0.5598 0.5595
Brugia malayi MH1 domain containing protein 0.007 0.0377 0.0497
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0229 0.0273
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.0085 0.0294
Schistosoma mansoni lipoxygenase 0.0413 0.2978 0.3639
Echinococcus multilocularis RUN 0.0148 0.0967 0.096
Loa Loa (eye worm) hypothetical protein 0.0028 0.0065 0.0085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0657 0.4822 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0204 0.1397 0.1884
Treponema pallidum heat shock protein 90 0.0148 0.0969 0.19
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.03 0.0612
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0144 0.0943 0.0937
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0151 0.0144
Brugia malayi jmjC domain containing protein 0.0124 0.0786 0.1034
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.0085 0.0294
Leishmania major heat shock protein, putative 0.0094 0.056 0.1153
Brugia malayi Intermediate filament tail domain containing protein 0.0091 0.0535 0.0704
Loa Loa (eye worm) heat shock protein 90 0.0168 0.1123 0.1477
Brugia malayi tailless protein 0.0022 0.0018 0.0023
Schistosoma mansoni steroid hormone receptor ad4bp 0.0047 0.0206 0.0244
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.022 0.1515 0.1994
Trichomonas vaginalis DNA topoisomerase II, putative 0.0028 0.0065 0.012
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0204 0.1397 0.1884
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0009
Brugia malayi beta-lactamase family protein 0.0156 0.1029 0.1355
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0047 0.0206 0.0271
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0091 0.0535 0.0704
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0018 0.0011
Brugia malayi TAR-binding protein 0.0067 0.0356 0.0468
Toxoplasma gondii heat shock protein 90, putative 0.0168 0.1123 0.3907
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0154 0.1012 0.1006
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0028 0.0065 0.0226
Brugia malayi Niemann-Pick C1 protein precursor 0.0328 0.2332 0.307
Leishmania major hypothetical protein, conserved 0.0156 0.1029 0.2132
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0099 0.0192
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0028 0.0065 0.0121
Mycobacterium ulcerans heat shock protein 90 0.0148 0.0969 0.3924
Echinococcus multilocularis heat shock protein 90 0.0168 0.1123 0.1116
Echinococcus granulosus heat shock protein 90 0.014 0.0907 0.0901
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0028 0.0065 0.0226
Loa Loa (eye worm) hypothetical protein 0.0313 0.2223 0.2925
Onchocerca volvulus 0.0503 0.366 0.5183
Trypanosoma brucei heat shock protein, putative 0.0168 0.1123 0.2327
Loa Loa (eye worm) matrix metalloproteinase 0.0313 0.2223 0.2925
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0018 0.0013
Echinococcus multilocularis FTZ F1 alpha 0.0047 0.0206 0.0199
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0122 0.0115
Trichomonas vaginalis set domain proteins, putative 0.0242 0.1682 0.3479
Loa Loa (eye worm) hypothetical protein 0.0275 0.1934 0.2545
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0657 0.4822 1
Brugia malayi MH2 domain containing protein 0.1023 0.7598 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0022 0.0029
Echinococcus granulosus mothers against decapentaplegic 5 0.007 0.0377 0.0371
Schistosoma mansoni nuclear receptor 0.0022 0.0018 0.0013
Schistosoma mansoni survival motor neuron protein 0.011 0.0682 0.0826
Echinococcus granulosus survival motor neuron protein 1 0.0539 0.3929 0.3925
Mycobacterium tuberculosis Probable dehydrogenase 0.0204 0.1397 0.1884
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.009 0.0528 0.0706
Brugia malayi heat shock protein 90 0.0168 0.1123 0.1477
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0154 0.1012 0.1006
Brugia malayi hypothetical protein 0.0539 0.3929 0.5171
Schistosoma mansoni patched 1 0.0141 0.0915 0.1112
Mycobacterium tuberculosis Probable lipase LipD 0.0156 0.1029 0.1385
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0028 0.0065 0.0078
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.03 0.0612
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0144 0.0943 0.1953
Mycobacterium leprae Probable lipase LipE 0.0156 0.1029 0.4179
Schistosoma mansoni endoplasmin 0.0168 0.1123 0.1366
Schistosoma mansoni phd/f-box containing protein 0.0033 0.0099 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0047 0.0206 0.0271
Onchocerca volvulus Bile acid receptor homolog 0.0047 0.0206 0.0291
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0151 0.0144
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0018 0.0011
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0413 0.2978 0.2973
Schistosoma mansoni lamin 0.0091 0.0535 0.0647
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.005
Onchocerca volvulus 0.0313 0.2223 0.3147
Trypanosoma brucei protein kinase, putative 0.006 0.03 0.0612
Plasmodium falciparum DNA gyrase subunit B 0.0028 0.0065 0.0226
Schistosoma mansoni zinc finger protein 0.0034 0.0107 0.0122
Entamoeba histolytica transcription factor BTF3, putative 0.0075 0.0414 0.0846
Trichomonas vaginalis penicillin-binding protein, putative 0.0156 0.1029 0.2123
Loa Loa (eye worm) hypothetical protein 0.0085 0.0495 0.0651
Plasmodium vivax SET domain protein, putative 0.0031 0.008 0.028
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1341 1 1
Onchocerca volvulus 0.0047 0.0206 0.0291
Plasmodium vivax DNA topoisomerase II, putative 0.0028 0.0065 0.0226
Schistosoma mansoni hypothetical protein 0.0136 0.0877 0.1065
Trypanosoma cruzi Heat shock protein 83, putative 0.0168 0.1123 0.2327
Loa Loa (eye worm) hypothetical protein 0.009 0.0535 0.0703
Trichomonas vaginalis mercuric reductase, putative 0.0031 0.0085 0.0161
Brugia malayi beta-lactamase 0.0156 0.1029 0.1355
Toxoplasma gondii thioredoxin reductase 0.009 0.0528 0.1838
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0047 0.0206 0.0199
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0657 0.4822 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.03 0.0612
Echinococcus multilocularis lipoxygenase domain containing protein 0.0148 0.0967 0.096
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0204 0.1397 0.1884
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0028 0.0065 0.0121
Brugia malayi hypothetical protein 0.0148 0.0967 0.1272
Schistosoma mansoni zinc finger protein 0.0022 0.0018 0.0013
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.03 0.0395
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0156 0.1029 0.1252
Brugia malayi mothers against decapentaplegic homolog 3 0.0031 0.0085 0.0112
Giardia lamblia Grp94/Hsp90 0.0148 0.0969 0.1997
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.1012 0.1231
Mycobacterium ulcerans hypothetical protein 0.0156 0.1029 0.4171
Loa Loa (eye worm) steroid hormone receptor 0.0047 0.0206 0.0271
Loa Loa (eye worm) hypothetical protein 0.0028 0.0065 0.0085
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.0376 0.037
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0099 0.013
Plasmodium vivax heat shock protein 86, putative 0.0168 0.1123 0.3907
Brugia malayi mbt repeat family protein 0.005 0.0229 0.0302
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0122 0.024
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0037 0.0131 0.0124
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0657 0.4822 1
Brugia malayi kinase, mitochondrial precursor 0.0028 0.0065 0.0085
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0133 0.0853 0.0847
Trichomonas vaginalis heat shock protein, putative 0.0148 0.0969 0.1997
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.0085 0.0078
Schistosoma mansoni thyroid hormone receptor 0.0047 0.0206 0.0244
Loa Loa (eye worm) transcription factor SMAD2 0.1023 0.7598 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0028 0.0065 0.0058
Mycobacterium tuberculosis Conserved protein 0.0156 0.1029 0.1385
Mycobacterium tuberculosis Conserved protein 0.0028 0.0065 0.0078
Schistosoma mansoni hypothetical protein 0.1099 0.8171 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.031 0.2193 0.456
Schistosoma mansoni hypothetical protein 0.007 0.0376 0.0452
Onchocerca volvulus 0.0022 0.0018 0.0025
Echinococcus granulosus lipoxygenase domain containing protein 0.0148 0.0967 0.096
Echinococcus granulosus fetal alzheimer antigen falz 0.005 0.0229 0.0222
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0356 0.0349
Loa Loa (eye worm) hypothetical protein 0.0033 0.0099 0.013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0112
Loa Loa (eye worm) hypothetical protein 0.0156 0.1029 0.1355
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0122 0.0425
Trypanosoma cruzi heat shock protein 90, putative 0.0082 0.0474 0.0974
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0038 0.005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0206 0.0271
Echinococcus multilocularis lamin dm0 0.0091 0.0535 0.0528
Schistosoma mansoni smad1 5 8 and 0.007 0.0377 0.0454
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0229 0.0223
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0028 0.0065 0.0078
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0122 0.024
Brugia malayi hypothetical protein 0.0022 0.0018 0.0023
Onchocerca volvulus Matrilysin homolog 0.0953 0.7063 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.008 0.009
Brugia malayi jmjC domain containing protein 0.0033 0.0099 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0047 0.0206 0.0271
Brugia malayi nuclear hormone receptor 0.0022 0.0018 0.0023
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0028 0.0065 0.0236
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.0085 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0206 0.0271
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0333 0.2372 0.3122
Brugia malayi hypothetical protein 0.0025 0.0038 0.005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0344 0.2458 0.3321
Trypanosoma cruzi heat shock protein 85, putative 0.0168 0.1123 0.2327
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0018 0.0023
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0047 0.0206 0.0199
Toxoplasma gondii heat shock protein HSP90 0.0168 0.1123 0.3907
Loa Loa (eye worm) Smad1 0.007 0.0377 0.0497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0047 0.0206 0.0271
Loa Loa (eye worm) hypothetical protein 0.0091 0.0535 0.0704
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0028 0.0065 0.0121
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.0099 0.0192
Leishmania major basic transcription factor 3a, putative 0.0075 0.0414 0.085
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0271
Trypanosoma brucei heat shock protein, putative 0.0168 0.1123 0.2327
Plasmodium vivax glutathione reductase, putative 0.009 0.0528 0.1838
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0229 0.0223
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0028 0.0065 0.0236
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.0818 0.0993
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0229 0.0223
Brugia malayi Matrixin family protein 0.0313 0.2223 0.2925
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0023
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.014 0.0907 0.0901
Trypanosoma cruzi DNA topoisomerase II, putative 0.0028 0.0065 0.0121
Giardia lamblia Fructose-bisphosphate aldolase 0.0657 0.4822 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.031 0.2193 0.456
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0148 0.0969 0.1171
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0996 0.7387 1
Brugia malayi Hsp90 protein 0.0094 0.056 0.0736
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0094 0.056 0.0553
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.005
Brugia malayi Matrixin family protein 0.0313 0.2223 0.2925
Giardia lamblia Pms1-like protein 0.0028 0.0065 0.012
Echinococcus granulosus Polycystic kidney disease protein 0.0148 0.0967 0.096
Leishmania major DNA topoisomerase ii 0.0028 0.0065 0.0121
Loa Loa (eye worm) hypothetical protein 0.0172 0.1155 0.152
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0007 0.0009
Trypanosoma cruzi heat shock protein 90, putative 0.014 0.0907 0.1878
Trypanosoma cruzi heat shock protein 90, putative 0.0168 0.1123 0.2327
Echinococcus multilocularis expressed conserved protein 0.0308 0.2182 0.2176
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.0099 0.0345
Brugia malayi Bromodomain containing protein 0.0167 0.1111 0.1462
Echinococcus granulosus smad 0.007 0.0377 0.0371
Schistosoma mansoni hypothetical protein 0.0309 0.219 0.2674
Brugia malayi hypothetical protein 0.0503 0.366 0.4818
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.0085 0.0078
Echinococcus granulosus mothers against decapentaplegic 6 0.0031 0.0085 0.0078
Giardia lamblia Heat shock protein HSP 90-alpha 0.0168 0.1123 0.2317
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0124 0.0786 0.0779
Toxoplasma gondii ABC1 family protein 0.0156 0.1029 0.3582
Schistosoma mansoni lamin 0.0091 0.0535 0.0647
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0036 0.0122 0.024
Brugia malayi hypothetical protein 0.0156 0.1027 0.1352
Loa Loa (eye worm) hypothetical protein 0.0156 0.1029 0.1355
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0047 0.0206 0.0244
Plasmodium falciparum glutathione reductase 0.0031 0.0085 0.0294
Schistosoma mansoni hypothetical protein 0.0156 0.1027 0.125
Schistosoma mansoni transcription factor LCR-F1 0.0156 0.1027 0.125
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0915 0.1886
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.031 0.2193 0.456
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0085 0.0162
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Brugia malayi MH2 domain containing protein 0.0031 0.0085 0.0112
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0151 0.0144
Loa Loa (eye worm) doublecortin family protein 0.0148 0.0967 0.1272
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.1459 0.1921
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0206 0.0271
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0047 0.0206 0.0199
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.0099 0.0092
Brugia malayi jmjC domain containing protein 0.0128 0.0818 0.1077
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.1377 0.1371
Schistosoma mansoni hypothetical protein 0.0136 0.0877 0.1065
Loa Loa (eye worm) nuclear factor I 0.0039 0.0141 0.0186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0085 0.0162
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.0085 0.0162
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0065 0.0226
Trypanosoma cruzi heat shock protein 85, putative 0.0168 0.1123 0.2327
Echinococcus multilocularis tumor protein p63 0.0759 0.5598 0.5595
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.0099 0.0092
Mycobacterium tuberculosis Probable lipase LipE 0.0156 0.1029 0.1385
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.005 0.0229 0.0271
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0282 0.0371
Schistosoma mansoni pyruvate dehydrogenase 0.0028 0.0065 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0206 0.0271
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0018 0.0011
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0028 0.0065 0.0078
Giardia lamblia NADH oxidase lateral transfer candidate 0.0031 0.0085 0.0161
Brugia malayi isocitrate dehydrogenase 0.0036 0.0122 0.0161
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0271
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0151 0.0301
Echinococcus granulosus methyl CpG binding domain protein 2 0.0038 0.0136 0.0129
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Echinococcus multilocularis transcription factor btf3 0.0075 0.0414 0.0408
Brugia malayi PHD-finger family protein 0.0055 0.0268 0.0353
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.005
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0022 0.0029
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0144 0.0943 0.1146
Brugia malayi MH1 domain containing protein 0.0039 0.0141 0.0186
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0144 0.0943 0.1953
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0031 0.0085 0.0105
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0028 0.0065 0.012
Brugia malayi Matrixin family protein 0.0313 0.2223 0.2925
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0657 0.4822 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0018 0.0011
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0031 0.0085 0.0162
Loa Loa (eye worm) RNA binding protein 0.0067 0.0356 0.0468
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.0376 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0047 0.0206 0.0271
Schistosoma mansoni methyl-cpg binding protein mbd 0.0038 0.0136 0.0158
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0028 0.0065 0.0058
Trichomonas vaginalis receptor histidine kinase, putative 0.0028 0.0065 0.012
Toxoplasma gondii Hsp90 domain-containing protein 0.0399 0.2873 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0028 0.0065 0.012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0085 0.0162
Echinococcus multilocularis musashi 0.0091 0.0535 0.0528
Trichomonas vaginalis heat shock protein, putative 0.0148 0.0969 0.1997
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0047 0.0206 0.0271
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0654 0.4801 1
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Echinococcus granulosus lamin dm0 0.0091 0.0535 0.0528
Mycobacterium tuberculosis Conserved protein 0.0156 0.1029 0.1385
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0356 0.0468
Plasmodium falciparum basic transcription factor 3b, putative 0.0075 0.0414 0.1442
Brugia malayi hypothetical protein 0.0275 0.1934 0.2545
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0028 0.0065 0.0085
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0031 0.0085 0.0294
Loa Loa (eye worm) hypothetical protein 0.0156 0.1029 0.1355
Leishmania major heat shock protein 83-1 0.0168 0.1123 0.2327
Loa Loa (eye worm) hypothetical protein 0.0042 0.0168 0.0221
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0028 0.0065 0.0078
Onchocerca volvulus 0.0111 0.0691 0.0978
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.03 0.0612
Trichomonas vaginalis D-aminoacylase, putative 0.0156 0.1029 0.2123
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.0376 0.037
Brugia malayi hypothetical protein 0.0025 0.0038 0.005
Echinococcus multilocularis geminin 0.1099 0.8171 0.817
Onchocerca volvulus 0.0156 0.1029 0.1457
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.03 0.1045
Leishmania major developmentally regulated phosphoprotein-like protein 0.0028 0.0065 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0047 0.0206 0.0271
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.1048 0.7785 1
Trichomonas vaginalis heat shock protein, putative 0.0168 0.1123 0.2317
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0031 0.0085 0.0162
Schistosoma mansoni zinc finger protein 0.0043 0.0179 0.021
Brugia malayi MH2 domain containing protein 0.007 0.0377 0.0497
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0028 0.0065 0.0058
Brugia malayi MH1 domain containing protein 0.0039 0.0141 0.0186
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0333 0.2372 0.3205
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0092 0.0546 0.1124
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0112 0.0698 0.1441
Loa Loa (eye worm) hypothetical protein 0.02 0.1366 0.1798
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0018 0.0023
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.0038 0.0031
Trypanosoma cruzi transcription factor btf3, putative 0.0075 0.0414 0.085
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0099 0.013
Echinococcus multilocularis smad 0.007 0.0377 0.0371
Loa Loa (eye worm) matrixin family protein 0.0647 0.4746 0.6246
Trypanosoma cruzi ISWI complex protein 0.0034 0.0107 0.0208
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0282 0.0275
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.008 0.028
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0047 0.0206 0.0199
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.0099 0.0113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0657 0.4822 1
Echinococcus granulosus heat shock protein 0.0168 0.1123 0.1116
Loa Loa (eye worm) hypothetical protein 0.0328 0.2332 0.307
Schistosoma mansoni TGF-beta signal transducer Smad2 0.007 0.0377 0.0454
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0657 0.4822 1
Mycobacterium tuberculosis Probable reductase 0.0204 0.1397 0.1884
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0144 0.0943 0.1241
Echinococcus granulosus Protein patched homolog 1 0.0141 0.0915 0.0909
Loa Loa (eye worm) hypothetical protein 0.022 0.1515 0.1994
Plasmodium vivax thioredoxin reductase, putative 0.009 0.0528 0.1838
Loa Loa (eye worm) MBCTL1 0.0057 0.0282 0.0371
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0092 0.0546 0.1124
Mycobacterium ulcerans hydrolase 0.0333 0.2372 0.9652
Echinococcus multilocularis thyroid hormone receptor alpha 0.0047 0.0206 0.0199
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0018 0.0025
Trypanosoma brucei DNA topoisomerase ii 0.0028 0.0065 0.0121
Echinococcus granulosus Smad4 0.007 0.0377 0.0371
Brugia malayi photoreceptor-specific nuclear receptor 0.0047 0.0206 0.0271
Giardia lamblia Heat shock protein HSP 90-alpha 0.014 0.0907 0.1869
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0094 0.056 0.0553
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0007 0.0009
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0092 0.0546 0.1124
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0151 0.03

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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