Detailed information for compound 688563

Basic information

Technical information
  • TDR Targets ID: 688563
  • Name: 4-methyl-N-[1-(thiophene-2-carbonyl)-3,4-dihy dro-2H-quinolin-6-yl]benzenesulfonamide
  • MW: 412.525 | Formula: C21H20N2O3S2
  • H donors: 1 H acceptors: 3 LogP: 4.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)Nc1ccc2c(c1)CCCN2C(=O)c1cccs1
  • InChi: 1S/C21H20N2O3S2/c1-15-6-9-18(10-7-15)28(25,26)22-17-8-11-19-16(14-17)4-2-12-23(19)21(24)20-5-3-13-27-20/h3,5-11,13-14,22H,2,4,12H2,1H3
  • InChiKey: ZLJYLNJBITZDCS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methyl-N-[1-[oxo-(2-thienyl)methyl]-3,4-dihydro-2H-quinolin-6-yl]benzenesulfonamide
  • 4-methyl-N-(1-thiophen-2-ylcarbonyl-3,4-dihydro-2H-quinolin-6-yl)benzenesulfonamide
  • ZINC05099622
  • G503-0140
  • NCGC00131235-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0007 0.0051 0.0321
Loa Loa (eye worm) hypothetical protein 0.0073 0.1478 0.2212
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1478 0.8166
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0142 0.2987 0.3724
Schistosoma mansoni sugar transporter 0.0012 0.0165 0.0248
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0116 0.0227
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0096 0.0144
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Schistosoma mansoni cpg binding protein 0.0031 0.0578 0.0865
Brugia malayi ecdysteroid receptor 0.001 0.0116 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0165 0.0894
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0258 0.172
Leishmania major glucose transporter/membrane transporter D2, putative 0.0027 0.049 0.3294
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0007 0.0051 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0174
Brugia malayi hypothetical protein 0.0012 0.0165 0.0324
Echinococcus multilocularis calcium dependent protein kinase 0.0025 0.0446 0.0667
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Onchocerca volvulus Huntingtin homolog 0.0129 0.2705 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1225 0.1834
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0116 0.0174
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0258 0.172
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Echinococcus multilocularis glycyl tRNA synthetase 0.0005 0.0004 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0258 0.172
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0026 0.047 0.0704
Plasmodium vivax hypothetical protein, conserved 0.0073 0.1478 0.184
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0031 0.0565 0.106
Brugia malayi beta-lactamase family protein 0.0073 0.1478 0.2893
Echinococcus granulosus solute carrier family 22 0.0012 0.0165 0.0248
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0057 0.0085
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0009 0.0099 0.0645
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Brugia malayi nuclear receptor RXR 0.0005 0.0012 0.0024
Mycobacterium leprae Conserved hypothetical protein 0.0007 0.0051 0.0187
Toxoplasma gondii sugar transporter ST3 0.0012 0.0165 0.0305
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0364 0.7725
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0007 0.0051 0.0321
Brugia malayi steroid hormone receptor 0.001 0.0116 0.0227
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0088 0.1809 0.2708
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0258 0.0479
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0364 0.045
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0165 0.0248
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0293 0.0289
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0116 0.0227
Brugia malayi hypothetical protein 0.0005 0.0012 0.0024
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0027 0.0482 0.0722
Onchocerca volvulus 0.0012 0.0165 0.0611
Schistosoma mansoni hypothetical protein 0.0088 0.1809 0.2708
Trypanosoma brucei THT1 - hexose transporter, putative 0.0027 0.049 0.3294
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0116 0.0174
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1478 0.2212
Brugia malayi hypothetical protein 0.0012 0.0165 0.0324
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0532 0.3582
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0116 0.0174
Entamoeba histolytica hypothetical protein 0.0024 0.0412 0.6073
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0675 0.4555
Schistosoma mansoni ap endonuclease 0.0018 0.0293 0.0439
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0142 0.2987 0.5632
Trypanosoma brucei glucose transporter, putative 0.0027 0.049 0.3294
Schistosoma mansoni protein kinase 0.0027 0.0482 0.0722
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Schistosoma mansoni lysyl-tRNA synthetase 0.002 0.0323 0.0484
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0364 0.0713
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0905 0.1355
Trichomonas vaginalis glucose transporter, putative 0.0027 0.049 0.269
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0174
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0088 0.1809 0.2708
Leishmania major myo-inositol/proton symporter (MIT) 0.0012 0.0165 0.1095
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0594 0.059
Echinococcus granulosus calcium dependent protein kinase 0.0025 0.0446 0.0667
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0093 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0116 0.0227
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0258 0.172
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0012 0.0024
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0258 0.794
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.002 0.0323 0.2166
Echinococcus multilocularis snurportin 1 0.0312 0.668 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0027 0.0482 0.0944
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0939 0.1405
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0116 0.0174
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0293 0.1961
Onchocerca volvulus 0.0012 0.0165 0.0611
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0005 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0293 0.0361
Trypanosoma brucei glucose transporter 1E 0.0027 0.049 0.3294
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0675 0.1011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0116 0.0174
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.1478 0.1474
Echinococcus granulosus solute carrier family 22 0.0012 0.0165 0.0248
Schistosoma mansoni thyroid hormone receptor 0.001 0.0116 0.0174
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Mycobacterium ulcerans integral membrane transport protein 0.0012 0.0165 0.1095
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0364 0.0545
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0116 0.0174
Mycobacterium leprae conserved hypothetical protein 0.0073 0.1478 0.5814
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0012 0.0165 0.0201
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0053 0.0333
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0096 0.0144
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0258 0.0317
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0116 0.0174
Plasmodium vivax lysine--tRNA ligase, putative 0.002 0.0323 0.0399
Echinococcus multilocularis solute carrier family 22 0.0012 0.0165 0.0248
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.2274 0.227
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0012 0.0165 0.0161
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0939 0.1405
Loa Loa (eye worm) hypothetical protein 0.003 0.0559 0.0837
Echinococcus multilocularis solute carrier family 22 0.0012 0.0165 0.0248
Toxoplasma gondii protein kinase, putative 0.0248 0.53 1
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0007 0.0051 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0116 0.0227
Echinococcus multilocularis 0.0007 0.0051 0.0077
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0031 0.0565 0.3808
Echinococcus granulosus FTZ F1 alpha 0.001 0.0116 0.0174
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0258 0.0317
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0559 0.3766
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0051 0.0321
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0007 0.0051 0.0321
Onchocerca volvulus 0.001 0.0116 0.0428
Brugia malayi Cytochrome P450 family protein 0.0007 0.0051 0.0101
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1225 0.8286
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.1478 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0012 0.0165 0.1095
Loa Loa (eye worm) sugar transporter 0.0088 0.1809 0.2708
Brugia malayi Importin beta-1 subunit 0.0029 0.0532 0.1041
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0258 0.172
Trichomonas vaginalis glucose transporter, putative 0.0027 0.049 0.269
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0026 0.047 0.6945
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.1478 0.2212
Trichomonas vaginalis myo-inositol transporter, putative 0.0012 0.0165 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0116 0.0227
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0007 0.0051 0.0321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0116 0.0174
Brugia malayi Cytochrome P450 family protein 0.0016 0.0243 0.0476
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0116 0.0174
Onchocerca volvulus 0.0073 0.1478 0.5463
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0258 0.172
Loa Loa (eye worm) hypothetical protein 0.0027 0.0482 0.0722
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0088 0.1809 0.2708
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0007 0.0051 0.0047
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0258 0.172
Onchocerca volvulus Putative transporter 0.0012 0.0165 0.0611
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0007 0.0051 0.0321
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0194 0.029
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0364 0.045
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0006
Trypanosoma cruzi hexose transporter, putative 0.0027 0.049 0.3294
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0116 0.0174
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0258 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0116 0.0227
Plasmodium falciparum proline--tRNA ligase 0.0031 0.0565 0.0701
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0258 0.5438
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Schistosoma mansoni cpg binding protein 0.0031 0.0578 0.0865
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0007 0.0051 0.0047
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0959 0.1878
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0293 0.0574
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0293 0.1961
Onchocerca volvulus 0.0012 0.0165 0.0611
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0559 0.0693
Brugia malayi Cytochrome P450 family protein 0.0007 0.0051 0.0101
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.002 0.0323 0.2166
Plasmodium falciparum hexose transporter 0.0088 0.1809 0.2253
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.1478 1
Brugia malayi Cytochrome P450 family protein 0.0016 0.0243 0.0476
Leishmania major cytochrome p450-like protein 0.0016 0.0243 0.1622
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0258 0.0386
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Onchocerca volvulus 0.0012 0.0165 0.0611
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.2274 0.227
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0165 0.0894
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0258 0.0479
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0293 0.4305
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0675 0.4555
Leishmania major glucose transporter, lmgt2 0.0027 0.049 0.3294
Schistosoma mansoni glucose transport protein 0.0088 0.1809 0.2708
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0258 0.172
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0012 0.0165 0.0248
Schistosoma mansoni nuclear hormone receptor 0.001 0.0116 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0116 0.0227
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0027 0.0482 0.3243
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Entamoeba histolytica Ran family GTPase 0.0021 0.0364 0.5364
Chlamydia trachomatis proline--tRNA ligase 0.0009 0.0099 0.2978
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.5108 0.7646
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0258 0.1405
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0293 0.6199
Loa Loa (eye worm) hypothetical protein 0.0026 0.047 0.0704
Plasmodium falciparum calcium-dependent protein kinase 2 0.0027 0.0482 0.0597
Trypanosoma brucei glucose transporter, putative 0.0027 0.049 0.3294
Loa Loa (eye worm) hypothetical protein 0.0129 0.2705 0.4049
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0194 0.029
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0412 0.2259
Loa Loa (eye worm) hypothetical protein 0.0073 0.1478 0.2212
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0005 0.0004 0.0008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0905 0.1355
Onchocerca volvulus 0.0012 0.0165 0.0611
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0007 0.0051 0.0321
Brugia malayi hypothetical protein 0.0129 0.2705 0.5296
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0258 0.172
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0675 0.3719
Mycobacterium tuberculosis Probable reductase 0.0109 0.2274 0.227
Trypanosoma brucei glucose transporter, putative 0.0027 0.049 0.3294
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0027 0.0482 0.0597
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0012 0.0165 0.1095
Mycobacterium ulcerans lysyl-tRNA synthetase 0.002 0.0323 0.2166
Leishmania major glucose transporter, lmgt1 0.0027 0.049 0.3294
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0116 0.0174
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0258 0.172
Echinococcus multilocularis solute carrier family 22 0.0012 0.0165 0.0248
Echinococcus multilocularis synaptic vesicle 2 protein 0.0012 0.0165 0.0248
Leishmania major hypothetical protein, conserved 0.003 0.0559 0.3766
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0116 0.0174
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Brugia malayi hypothetical protein 0.0012 0.0165 0.0324
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0174
Plasmodium falciparum transportin 0.0006 0.0017 0.0016
Echinococcus granulosus solute carrier family 22 0.0012 0.0165 0.0248
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0675 0.1268
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0939 0.1167
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Brugia malayi glutathione reductase 0.0048 0.0939 0.1837
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0364 0.0545
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0293 0.1961
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0007 0.0051 0.0047
Trichomonas vaginalis helicase, putative 0.0007 0.0043 0.0213
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0088 0.1809 0.2708
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0031 0.0565 0.3808
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Plasmodium falciparum protein kinase 6 0.0373 0.8014 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0088 0.1809 0.2708
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0258 0.172
Onchocerca volvulus 0.0012 0.0165 0.0611
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0007 0.0051 0.0047
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0675 0.4555
Schistosoma mansoni coup transcription factor 0.001 0.0116 0.0174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0905 0.1355
Schistosoma mansoni protein kinase 0.0027 0.0482 0.0722
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Plasmodium vivax transportin, putative 0.0006 0.0017 0.0016
Brugia malayi beta-lactamase family protein 0.0073 0.1478 0.2893
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0007 0.0051 0.0047
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0007 0.0051 0.0321
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0116 0.0174
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0027 0.0482 0.0722
Brugia malayi hypothetical protein 0.0005 0.0012 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1225 0.1834
Brugia malayi kap beta 3 protein 0.0006 0.0017 0.0033
Echinococcus multilocularis importin 5 0.0006 0.0017 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0905 0.1355
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0165 0.0248
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0293 0.1601
Echinococcus granulosus General substrate transporter 0.0075 0.154 0.2305
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1118 0.2103
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0293 0.0361
Mycobacterium ulcerans sugar transporter 0.0012 0.0165 0.1095
Onchocerca volvulus 0.0012 0.0165 0.0611
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0165 0.0324
Brugia malayi Thioredoxin reductase 0.0048 0.0939 0.1837
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0258 0.0317
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1478 0.8166
Brugia malayi nuclear receptor NHR-88 0.001 0.0116 0.0227
Schistosoma mansoni inositol monophosphatase 0.0036 0.0675 0.1011
Trypanosoma brucei glucose transporter 2A 0.0027 0.049 0.3294
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0057 0.0085
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0258 0.172
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0012 0.0019
Brugia malayi Cam kinase protein 1 0.0027 0.0482 0.0944
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1225 0.8286
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0243 0.1622
Echinococcus granulosus glycyl tRNA synthetase 0.0005 0.0004 0.0006
Mycobacterium leprae putative cytochrome p450 0.0007 0.0051 0.0187
Plasmodium vivax glutathione reductase, putative 0.0048 0.0939 0.1167
Toxoplasma gondii cytochrome p450 superfamily protein 0.0007 0.0051 0.0089
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0007 0.0051 0.0047
Onchocerca volvulus 0.0049 0.0959 0.3547
Schistosoma mansoni protein kinase 0.0027 0.0482 0.0722
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0174
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0905 0.1773
Echinococcus granulosus Threonyl tRNA synthetase C 0.0005 0.0004 0.0006
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0116 0.0227
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0162 0.0317
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.2274 0.227
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0005 0.0004 0.0008
Brugia malayi lysyl-tRNA synthetase 0.002 0.0323 0.0633
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0017 0.0259 0.1006
Mycobacterium tuberculosis Conserved protein 0.0073 0.1478 0.1474
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0007 0.0051 0.0321
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0165 0.0324
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0323 0.1769
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0482 0.0722
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1225 0.2306
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0243 0.0364
Toxoplasma gondii lysine-tRNA ligase 0.002 0.0323 0.0603
Schistosoma mansoni ran 0.0021 0.0364 0.0545
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0364 0.2443
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0007 0.0051 0.0321
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0017 0.0024
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0293 0.1961
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1225 0.1834
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0007 0.0051 0.0321
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0088 0.1809 0.2708
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0026 0.047 0.0704
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Schistosoma mansoni glucose transporter 0.0012 0.0165 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0116 0.0227
Brugia malayi Sugar transporter family protein 0.0012 0.0165 0.0324
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0293 0.1961
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1478 0.8166
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0007 0.0051 0.0321
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0239 0.5108 0.7646
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.5108 0.7646
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0293 0.0439
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0594 0.2326
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0007 0.0051 0.0321
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Onchocerca volvulus 0.0012 0.0165 0.0611
Toxoplasma gondii thioredoxin reductase 0.0048 0.0939 0.1765
Mycobacterium ulcerans lipase LipD 0.0073 0.1478 1
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0243 0.1622
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.2539 0.2536
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0116 0.0174
Onchocerca volvulus 0.0012 0.0165 0.0611
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0012 0.0165 0.0248
Plasmodium falciparum thioredoxin reductase 0.0017 0.0258 0.0317
Schistosoma mansoni lysyl-tRNA synthetase 0.002 0.0323 0.0484
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0258 0.0386
Leishmania major importin beta-1 subunit, putative 0.0024 0.0412 0.2766
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Toxoplasma gondii sugar transporter ST2 0.0012 0.0165 0.0305
Trypanosoma brucei THT1 - hexose transporter, putative 0.0027 0.049 0.3294
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0293 0.1601
Trypanosoma cruzi hexose transporter, putative 0.0027 0.049 0.3294
Echinococcus multilocularis cpg binding protein 0.0031 0.0578 0.0865
Leishmania major cytochrome p450-like protein 0.0007 0.0051 0.0321
Loa Loa (eye worm) beta-lactamase 0.0073 0.1478 0.2212
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1478 0.8166
Echinococcus multilocularis transportin 1 0.0006 0.0017 0.0025
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0412 0.2259
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0116 0.0174
Plasmodium falciparum protein kinase 7 0.0248 0.53 0.6612
Onchocerca volvulus 0.0012 0.0165 0.0611
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0017 0.0024
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0007 0.0051 0.0321
Treponema pallidum prolyl-tRNA synthetase 0.0009 0.0099 0.329
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0364 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0116 0.0227
Mycobacterium ulcerans beta-lactamase 0.0073 0.1478 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0027 0.0482 0.0597
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0258 0.0504
Toxoplasma gondii exonuclease III APE 0.0018 0.0293 0.0546
Brugia malayi Sugar transporter family protein 0.0012 0.0165 0.0324
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0088 0.1809 0.2708
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0116 0.0428
Plasmodium falciparum importin beta, putative 0.0029 0.0532 0.0659
Entamoeba histolytica protein kinase, putative 0.0027 0.0482 0.7121
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0043 0.0213
Schistosoma mansoni sugar transporter 0.0012 0.0165 0.0248
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0007 0.0051 0.0047
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0007 0.0051 0.0321
Trichomonas vaginalis sugar transporter, putative 0.0027 0.049 0.269
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1478 0.8166
Plasmodium vivax sugar transporter, putative 0.0012 0.0165 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Schistosoma mansoni sugar transporter 0.0012 0.0165 0.0248
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0006 0.0017 0.0085
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1478 0.2212
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0116 0.0174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0116 0.0174
Trichomonas vaginalis sugar transport protein, putative 0.0012 0.0165 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0165 0.0324
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Loa Loa (eye worm) hypothetical protein 0.0073 0.1478 0.2212
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0005 0.0004 0.0006
Plasmodium falciparum lysine--tRNA ligase 0.002 0.0323 0.0399
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0905 0.1355
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1478 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0116 0.0174
Loa Loa (eye worm) glutathione reductase 0.0048 0.0939 0.1405
Leishmania major lysyl-tRNA synthetase, putative 0.002 0.0323 0.2166
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0007 0.0051 0.0321
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0258 0.1405
Loa Loa (eye worm) hypothetical protein 0.0009 0.0088 0.0132
Trypanosoma brucei glucose transporter, putative 0.0027 0.049 0.3294
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0905 0.1355
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0258 0.0386
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0221 0.147
Onchocerca volvulus 0.0073 0.1478 0.5463
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0007 0.0051 0.0047
Schistosoma mansoni glucose transport protein 0.0088 0.1809 0.2708
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0258 0.172
Echinococcus granulosus Sugar transporter ERD6 protein 0.0012 0.0165 0.0248
Brugia malayi major facilitator superfamily protein 0.0012 0.0165 0.0324
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0675 1
Trichomonas vaginalis glucose transporter, putative 0.0012 0.0165 0.0894
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.1478 0.1474
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0012 0.0019
Trypanosoma brucei trypanothione reductase 0.0048 0.0939 0.6341
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0017 0.0271 0.1477
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0017 0.0025
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0019
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0532 0.3582
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0116 0.0174
Giardia lamblia Prolyl-tRNA synthetase 0.0026 0.047 1
Toxoplasma gondii sugar transporter ST1 0.0012 0.0165 0.0305
Plasmodium falciparum glutathione reductase 0.0048 0.0939 0.1167
Loa Loa (eye worm) cytochrome P450 0.0007 0.0051 0.0077
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.1478 0.1474
Trypanosoma brucei THT1 - hexose transporter, putative 0.0027 0.049 0.3294
Brugia malayi hypothetical protein 0.0239 0.5108 1
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0364 0.2443
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0675 0.4555
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0007 0.0051 0.0047
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0116 0.0174
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0116 0.0174
Loa Loa (eye worm) inositol-1 0.0036 0.0675 0.1011
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0051 0.0321
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0043 0.0213
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.2274 0.8954
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0258 0.0254
Schistosoma mansoni hypothetical protein 0.0007 0.0051 0.0077
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0007 0.0051 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0213
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0007 0.0051 0.0047
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0258 0.172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0116 0.0174
Mycobacterium tuberculosis Conserved protein 0.0073 0.1478 0.1474
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.0213
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0007 0.0051 0.0047
Trypanosoma brucei glucose transporter, putative 0.0027 0.049 0.3294
Loa Loa (eye worm) hypothetical protein 0.002 0.0323 0.0484
Plasmodium falciparum thioredoxin reductase 0.0048 0.0939 0.1167
Chlamydia trachomatis lysine--tRNA ligase 0.002 0.0323 1
Brugia malayi hypothetical protein 0.003 0.0559 0.1095
Giardia lamblia Lysyl-tRNA synthetase 0.002 0.0323 0.6849
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0243 0.0364
Echinococcus multilocularis lysyl tRNA synthetase 0.002 0.0323 0.0484
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.2274 0.227
Leishmania major cytochrome p450-like protein 0.0007 0.0051 0.0321
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0293 0.0439
Plasmodium falciparum calcium-dependent protein kinase 4 0.0027 0.0482 0.0597
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0007 0.0051 0.0321
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0027 0.0482 0.0903
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0905 0.1355
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0027 0.0482 0.0903
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0939 0.1405
Brugia malayi hypothetical protein 0.002 0.0324 0.0635
Entamoeba histolytica protein kinase, putative 0.0027 0.0482 0.7121
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0258 0.172
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Trichomonas vaginalis CAMK family protein kinase 0.0027 0.0482 0.2648
Entamoeba histolytica HEAT repeat domain containing protein 0.0006 0.0017 0.0188
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0258 0.172
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0026 0.047 0.0921
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0007 0.0051 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0116 0.0227
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0027 0.0482 0.0722
Onchocerca volvulus 0.0012 0.0165 0.0611
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0116 0.0227
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0007 0.0051 0.0047
Echinococcus granulosus lysyl tRNA synthetase 0.002 0.0323 0.0484
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0293 0.0439
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0675 0.3719
Loa Loa (eye worm) hypothetical protein 0.0073 0.1478 0.2212
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0017 0.0259 0.0255
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0116 0.0174
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0012 0.0024
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0412 0.2766
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0116 0.0174
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0017 0.0025
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0017 0.0259 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0213
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.2539 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0027 0.0482 0.0597
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0116 0.0174
Echinococcus multilocularis translational activator gcn1 0.0006 0.0017 0.0025
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0007 0.0051 0.0321
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0364 0.068
Schistosoma mansoni importin-beta 2 0.0006 0.0017 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0559 0.3766
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Leishmania major glucose transporter, lmgt3 0.0027 0.049 0.3294
Echinococcus granulosus cpg binding protein 0.0031 0.0578 0.0865
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0007 0.0051 0.0047
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.1478 0.2212
Leishmania major hypothetical protein, conserved 0.0073 0.1478 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0027 0.0482 0.0722
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0939 0.6341
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0905 0.1355
Loa Loa (eye worm) hypothetical protein 0.0021 0.0363 0.0543
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0165 0.0305
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0258 0.3777
Loa Loa (eye worm) hypothetical protein 0.0026 0.047 0.0704
Trypanosoma brucei glucose transporter, putative 0.0027 0.049 0.3294
Brugia malayi CXXC zinc finger family protein 0.003 0.0541 0.1059
Onchocerca volvulus 0.0012 0.0165 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0213
Echinococcus granulosus transportin 1 0.0006 0.0017 0.0025
Schistosoma mansoni glycyl-tRNA synthetase 0.0005 0.0004 0.0006
Brugia malayi major facilitator superfamily protein 0.0012 0.0165 0.0324
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0088 0.1809 0.2708
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0027 0.0482 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0258 0.172
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Mycobacterium ulcerans hypothetical protein 0.0073 0.1478 1
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0675 0.1011
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0019
Leishmania major GTP-binding protein, putative 0.0021 0.0364 0.2443
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.0213
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0116 0.0174
Trichomonas vaginalis hypothetical protein 0.0006 0.0017 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0165 0.0894
Schistosoma mansoni inositol monophosphatase 0.0036 0.0675 0.1011
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0007 0.0051 0.0321
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0559 0.0693
Trichomonas vaginalis ran, putative 0.0021 0.0364 0.1995
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0213
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0026 0.047 0.0921
Loa Loa (eye worm) hypothetical protein 0.0073 0.1478 0.2212
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0165 0.0894
Brugia malayi glycyl-tRNA synthetase 0.0005 0.0004 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0116 0.0227
Brugia malayi RNA, U transporter 1 0.0083 0.1704 0.3335
Schistosoma mansoni ap endonuclease 0.0018 0.0293 0.0439
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.1478 0.1474
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.1478 0.1474
Brugia malayi nuclear hormone receptor 0.001 0.0116 0.0227
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0027 0.0482 0.0597
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0116 0.0174
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0027 0.0482 0.0722
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0057 0.0085
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1225 0.1222
Plasmodium vivax proline--tRNA ligase, putative 0.0031 0.0565 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0243 0.1622
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0243 0.0364
Onchocerca volvulus Huntingtin homolog 0.0129 0.2705 1
Schistosoma mansoni hypothetical protein 0.0014 0.0194 0.029
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0559 0.0693
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0675 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0012 0.0165 0.2403
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0174
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.1478 0.1474
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.1478 0.2212
Trypanosoma cruzi glucose transporter, putative 0.0012 0.0165 0.1095
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0027 0.0482 0.0722
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0012 0.0165 0.1095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.0213
Loa Loa (eye worm) hypothetical protein 0.0073 0.1478 0.2212
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0007 0.0051 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0213
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0026 0.047 0.0704
Echinococcus granulosus translational activator gcn1 0.0006 0.0017 0.0025
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.1478 1
Leishmania major trypanothione reductase 0.0048 0.0939 0.6341
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0007 0.0051 0.0047
Loa Loa (eye worm) hypothetical protein 0.0129 0.2705 0.4049
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0116 0.0428
Echinococcus granulosus importin 5 0.0006 0.0017 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0116 0.0227
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0007 0.0051 0.0047
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0012 0.0165 0.0161
Onchocerca volvulus 0.0012 0.0165 0.0611
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0026 0.047 0.1839
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0293 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0258 0.172
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.049 0.269
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0258 0.172
Echinococcus multilocularis solute carrier family 22 0.0012 0.0165 0.0248
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0026 0.047 0.0704
Mycobacterium leprae Probable lipase LipE 0.0073 0.1478 0.5814
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.2274 0.227
Leishmania major hypothetical protein, conserved 0.0006 0.0017 0.0085
Entamoeba histolytica hypothetical protein 0.002 0.0323 0.4756
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0939 0.0935
Onchocerca volvulus 0.0073 0.1478 0.5463
Loa Loa (eye worm) hypothetical protein 0.0029 0.0532 0.0796
Trichomonas vaginalis esterase, putative 0.0073 0.1478 0.8166
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0027 0.0482 0.0722
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0051 0.0077
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1225 0.8286
Plasmodium falciparum mitogen-activated protein kinase 2 0.0142 0.2987 0.3724
Mycobacterium tuberculosis Conserved protein 0.0073 0.1478 0.1474
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0057 0.0085
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.0213
Loa Loa (eye worm) sugar transporter 0.0012 0.0165 0.0248
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0116 0.0174
Trichomonas vaginalis sugar transporter, putative 0.0027 0.049 0.269
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.1478 0.1474
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0116 0.0174
Echinococcus multilocularis General substrate transporter 0.0075 0.154 0.2305
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.668 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0116 0.0227
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.002 0.0323 0.126
Schistosoma mansoni sugar transporter 0.0012 0.0165 0.0248
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0541 0.081
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0096 0.0144
Giardia lamblia Sugar-proton symporter 0.0012 0.0165 0.346
Plasmodium falciparum calcium-dependent protein kinase 3 0.0027 0.0482 0.0597
Plasmodium vivax CDK-related protein kinase 6, putative 0.0373 0.8014 1
Toxoplasma gondii ABC1 family protein 0.0073 0.1478 0.2783
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.0051 0.0077
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0258 0.172
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0007 0.0051 0.0321
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0293 0.4305
Schistosoma mansoni cytochrome P450 0.0007 0.0051 0.0077
Treponema pallidum NADH oxidase 0.0017 0.0258 0.8773
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0005 0.0004 0.0006
Brugia malayi cytochrome P450 0.0007 0.0051 0.0101
Brugia malayi follicle stimulating hormone receptor 0.0239 0.5095 0.9975
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.1478 0.2893
Schistosoma mansoni cpg binding protein 0.003 0.0541 0.081
Onchocerca volvulus 0.003 0.0541 0.2
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1264 0.1892
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0116 0.0174
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0027 0.0482 0.0722
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0012 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0213
Trypanosoma cruzi hexose transporter, putative 0.0027 0.049 0.3294
Echinococcus granulosus snurportin 1 0.0312 0.668 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.0213
Schistosoma mansoni ran 0.0021 0.0364 0.0545
Leishmania major hypothetical protein, conserved 0.0012 0.0165 0.1095
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0174
Toxoplasma gondii facilitative glucose transporter GT1 0.0088 0.1809 0.3408
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.2539 0.2536
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0364 0.2443
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0031 0.0565 0.3808
Trichomonas vaginalis sugar transporter, putative 0.0027 0.049 0.269
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0559 0.3766
Trypanosoma cruzi hexose transporter, putative 0.0012 0.0165 0.1095
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0019
Plasmodium vivax calcium-dependent protein kinase, putative 0.0027 0.0482 0.0597
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0412 0.2259
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0174
Schistosoma mansoni hypothetical protein 0.0312 0.668 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0258 0.3777
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0213
Brugia malayi Inositol-1 0.0036 0.0675 0.1322
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0007 0.0051 0.0047
Brugia malayi Sugar transporter family protein 0.0088 0.1809 0.3542
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1225 0.8286
Plasmodium vivax importin-beta 2, putative 0.0029 0.0532 0.0659
Brugia malayi beta-lactamase 0.0073 0.1478 0.2893
Echinococcus granulosus importin subunit beta 1 0.0029 0.0532 0.0796
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1225 0.1834
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0243 0.1622
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0116 0.0174
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1478 1
Schistosoma mansoni importin beta-1 0.0029 0.0532 0.0796
Trypanosoma cruzi hexose transporter 0.0027 0.049 0.3294
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0162 0.0317
Schistosoma mansoni survival motor neuron protein 0.0049 0.0959 0.1436
Echinococcus granulosus synaptic vesicle 2 protein 0.0012 0.0165 0.0248
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0559 0.1048
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0019
Onchocerca volvulus 0.0012 0.0165 0.0611
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.0213
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0027 0.0482 0.0722
Onchocerca volvulus 0.0012 0.0165 0.0611
Loa Loa (eye worm) hypothetical protein 0.0012 0.0165 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0116 0.0174
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.5095 0.7627
Trichomonas vaginalis sugar transporter, putative 0.0012 0.0165 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.1809 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0007 0.0051 0.0321
Schistosoma mansoni glucose transport protein 0.0088 0.1809 0.2708
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0116 0.0428
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0116 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0116 0.0227
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0116 0.0174
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0675 0.4555
Leishmania major protein kinase, putative 0.0027 0.0482 0.3243
Plasmodium falciparum glutathione reductase 0.0017 0.0258 0.0317
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0532 0.0997
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.2539 0.2536
Trypanosoma brucei glucose transporter, putative 0.0027 0.049 0.3294
Trypanosoma brucei glucose transporter, putative 0.0027 0.049 0.3294
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0031 0.0565 0.3808
Plasmodium vivax hexose transporter 0.0088 0.1809 0.2253
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0532 0.0796
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0031 0.0565 0.3808
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0174
Trypanosoma brucei sugar transporter, putative 0.0012 0.0165 0.1095
Echinococcus granulosus solute carrier family 22 0.0012 0.0165 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0213
Schistosoma mansoni hypothetical protein 0.0049 0.0959 0.1436
Mycobacterium ulcerans lysyl-tRNA synthetase 0.002 0.0323 0.2166
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0011 0.0132 0.0198
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0675 0.3719
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.049 0.269
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0027 0.0482 0.0903
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0165 0.0894
Giardia lamblia Hexose transporter 0.0012 0.0165 0.346
Trypanosoma cruzi sugar transporter, putative 0.0012 0.0165 0.1095
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0007 0.0051 0.0321
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0026 0.047 0.2583
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0027 0.0482 0.0722
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0007 0.0051 0.0321
Onchocerca volvulus 0.0012 0.0165 0.0611
Schistosoma mansoni thyroid hormone receptor 0.001 0.0116 0.0174

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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