TDR Targets

Basic information

Technical information

TDR Targets ID: 722022
Name: 2-[7-[(2-bromophenyl)methoxy]-4,8-dimethyl-2- oxochromen-3-yl]acetic acid
MW: 417.25 | Formula: C20H17BrO5
H donors: 1 H acceptors: 3 LogP: 3.82 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)Cc1c(=O)oc2c(c1C)ccc(c2C)OCc1ccccc1Br
InChi: 1S/C20H17BrO5/c1-11-14-7-8-17(25-10-13-5-3-4-6-16(13)21)12(2)19(14)26-20(24)15(11)9-18(22)23/h3-8H,9-10H2,1-2H3,(H,22,23)
InChiKey: UDVCXTJFAHGQIZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[7-[(2-bromophenyl)methoxy]-4,8-dimethyl-2-oxo-chromen-3-yl]acetic acid
2-[7-[(2-bromophenyl)methoxy]-4,8-dimethyl-2-oxo-3-chromenyl]acetic acid
2-[7-(2-bromobenzyl)oxy-2-keto-4,8-dimethyl-chromen-3-yl]acetic acid
2-[7-[(2-bromophenyl)methoxy]-4,8-dimethyl-2-oxo-chromen-3-yl]ethanoic acid
STOCK1N-38678

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein tyrosine phosphatase, non-receptor type 11	Starlite/ChEMBL	No references
Homo sapiens	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	Starlite/ChEMBL	No references
Homo sapiens	dual specificity phosphatase 3	Starlite/ChEMBL	No references
Homo sapiens	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Plasmodium falciparum	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania braziliensis	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Neospora caninum	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	ko:K07293 protein tyrosine phosphatase, non-receptor type 11, putative	Get druggable targets OG5_130331	All targets in OG5_130331
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	Get druggable targets OG5_130331	All targets in OG5_130331
Echinococcus multilocularis		Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Echinococcus granulosus	CTD small phosphatase protein like	Get druggable targets OG5_127075	All targets in OG5_127075
Entamoeba histolytica	NLI interacting factor-like phosphatase domain-containing protein	Get druggable targets OG5_127075	All targets in OG5_127075
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Plasmodium knowlesi	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	IPR000242,Tyrosine specific protein phosphatase,domain-containing	Get druggable targets OG5_130331	All targets in OG5_130331
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Babesia bovis	Dullard-like phosphatase domain containing protein	Get druggable targets OG5_127075	All targets in OG5_127075
Trypanosoma congolense	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Trypanosoma congolense	TFIIF-stimulated CTD phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	protein-tyrosine phosphatase	Get druggable targets OG5_130331	All targets in OG5_130331
Candida albicans	Plasma membrane Sodium Response 1	Get druggable targets OG5_127075	All targets in OG5_127075
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium yoelii	NLI interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	Protein-tyrosine phosphatase containing protein	Get druggable targets OG5_130331	All targets in OG5_130331
Candida albicans	Plasma membrane Sodium Response 1	Get druggable targets OG5_127075	All targets in OG5_127075
Trypanosoma brucei gambiense	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1	Get druggable targets OG5_127075	All targets in OG5_127075
Trypanosoma brucei	Mitochondrial import inner membrane translocase subunit TIM50	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	dullard protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium berghei	NLI interacting factor-like phosphatase	Get druggable targets OG5_127075	All targets in OG5_127075
Neospora caninum	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Toxoplasma gondii	Dullard family phosphatase domain-containing protein	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania donovani	dullard-like phosphatase domain containing protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania infantum	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma japonicum	CTD small phosphatase-like protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	Get druggable targets OG5_127075	All targets in OG5_127075
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium knowlesi	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma japonicum	ko:K01090 protein phosphatase [EC3.1.3.16], putative	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	Get druggable targets OG5_134995	All targets in OG5_134995
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium berghei	NLI interacting factor-like phosphatase	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	dullard protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Giardia lamblia	Nuclear LIM interactor-interacting factor 1	Get druggable targets OG5_127075	All targets in OG5_127075
Entamoeba histolytica	dual specificity protein phosphatase, putative	Get druggable targets OG5_134995	All targets in OG5_134995
Trichomonas vaginalis	dullard protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium yoelii	NLI interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	Get druggable targets OG5_127075	All targets in OG5_127075
Theileria parva	nuclear LIM interactor-interacting factor 1, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania major	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	TFIIF-stimulated CTD phosphatase, putative	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	260 aa	263 aa	27.0 %
Trypanosoma brucei	kinetoplastid-specific dual specificity phosphatase, putative	dual specificity phosphatase 3	185 aa	182 aa	25.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.073	0.0763
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0018	0.009	0.0639
Trypanosoma cruzi	target of rapamycin kinase 3	0.0018	0.009	0.0639
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0018	0.0095	0.0165
Echinococcus granulosus	fetal alzheimer antigen falz	0.0046	0.0497	0.052
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Giardia lamblia	DINP protein human, muc B family	0.0019	0.011	0.0146
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0013	0.0027	0.0279
Brugia malayi	AF-10 protein	0.0012	0.0002	0.0004
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.017	0.0118
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0058	0.0101
Loa Loa (eye worm)	PHD-finger family protein	0.004	0.042	0.0731
Brugia malayi	hypothetical protein	0.012	0.1584	0.276
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.011	0.0115
Trypanosoma cruzi	metacaspase, putative	0.0078	0.0961	0.6789
Onchocerca volvulus		0.0059	0.069	0.0921
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.011	0.0191
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.073	0.0763
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0241	0.0253
Echinococcus multilocularis	snurportin 1	0.0299	0.4174	0.4365
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0109	0.1416	1
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	0.0015	0.0053	0.0055
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.0454	0.0475
Schistosoma mansoni	hypothetical protein	0.0048	0.0536	0.056
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0018	0.0095	0.0099
Echinococcus granulosus	zinc finger protein	0.004	0.0413	0.0432
Brugia malayi	beta-lactamase family protein	0.0035	0.0343	0.0597
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.009	0.0639
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0018	0.0095	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1059
Trypanosoma brucei	unspecified product	0.0019	0.011	0.0775
Echinococcus granulosus	tar DNA binding protein	0.0062	0.073	0.0763
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0108	0.1399	0.1463
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0024	0.0186	0.0194
Entamoeba histolytica	hypothetical protein	0.0024	0.0186	0.0134
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0101	0.0048
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0343	0.0359
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0059	0.069	0.7175
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.073	0.1271
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.017	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0241	0.0421
Schistosoma mansoni	importin beta-1	0.0028	0.0241	0.0253
Echinococcus granulosus	snurportin 1	0.0299	0.4174	0.4365
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0078	0.0961	0.0913
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.017	0.0327
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0059	0.069	0.0721
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0018	0.0095	0.0099
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0078	0.0961	0.0913
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.0766	0.0801
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0048	0.0531	0.0555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0188	0.2565	0.2682
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0101	0.0048
Brugia malayi	jmjC domain containing protein	0.0048	0.0531	0.0925
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.017	0.0479
Echinococcus granulosus	GPCR family 2	0.0015	0.0058	0.006
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0018	0.0095	0.0099
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0018	0.0095	0.0099
Plasmodium vivax	multidomain scavenger receptor, putative	0.0038	0.0394	0.4095
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0961	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1173	0.2043
Toxoplasma gondii	PHD-finger domain-containing protein	0.0012	0.0002	0.0022
Brugia malayi	PHD-finger family protein	0.005	0.0564	0.0982
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Trypanosoma cruzi	metacaspase, putative	0.0078	0.0961	0.6789
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Plasmodium falciparum	NLI interacting factor-like phosphatase, putative	0.0015	0.0053	0.0547
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Schistosoma mansoni	polycystin 1-related	0.0038	0.0394	0.0412
Brugia malayi	Bromodomain containing protein	0.004	0.0413	0.072
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0101	0.0105
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0033	0.0318	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Brugia malayi	hypothetical protein	0.0018	0.0095	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0343	0.0597
Echinococcus granulosus	histone lysine methyltransferase setb	0.0092	0.1173	0.1226
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0608	0.0636
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0095	0.0099
Brugia malayi	beta-lactamase	0.0035	0.0343	0.0597
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0394	0.0686
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Brugia malayi	hypothetical protein	0.0035	0.0343	0.0598
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0109	0.1416	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Onchocerca volvulus	Cell death protein 3 homolog	0.0198	0.271	0.4049
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0015	0.0053	0.0547
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0101	0.0097
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0343	0.0901
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0078	0.0961	0.0913
Echinococcus multilocularis	hypothetical protein	0.0018	0.0095	0.0099
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0109	0.1416	1
Leishmania major	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0018	0.0095	0.0165
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.011	0.0127
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.009	0.0158
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0343	0.0901
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0316	0.0551
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0539	0.0939
Trypanosoma brucei	calpain, putative	0.0109	0.1416	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.017	0.0479
Schistosoma mansoni	ap endonuclease	0.0018	0.0101	0.0105
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0188	0.2565	0.2682
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0343	0.0597
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.3963	0.3932
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0394	0.0686
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0343	0.0358
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0514	0.0538
Giardia lamblia	Fructose-bisphosphate aldolase	0.0284	0.3963	1
Schistosoma mansoni	microtubule-associated protein tau	0.067	0.9563	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0048	0.0531	0.0555
Schistosoma mansoni	hypothetical protein	0.0015	0.0058	0.006
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0343	0.0291
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0018	0.0095	0.0099
Schistosoma mansoni	caspase-3 (C14 family)	0.0148	0.1988	0.2079
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0015	0.0053	0.0547
Trypanosoma cruzi	metacaspase, putative	0.0078	0.0961	0.6789
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0024	0.0173
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0101	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.1852	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0343	0.242
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0021	0.0134	0.014
Echinococcus multilocularis	dnaJ subfamily B	0.0398	0.5613	0.5869
Schistosoma mansoni	hypothetical protein	0.0026	0.0219	0.0229
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.0546	0.0571
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0109	0.1416	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0343	0.0901
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0165	0.1163
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.011	0.0127
Leishmania major	DNA polymerase eta, putative	0.0019	0.011	0.0775
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0343	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Onchocerca volvulus		0.012	0.1584	0.2306
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0608	0.1059
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0059	0.069	0.0721
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Brugia malayi	hypothetical protein	0.0018	0.0095	0.0165
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0101	0.0105
Schistosoma mansoni	hypothetical protein	0.0035	0.0346	0.0362
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0018	0.0095	0.0669
Brugia malayi	Pre-SET motif family protein	0.0407	0.5741	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.009	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0316	0.0551
Loa Loa (eye worm)	hypothetical protein	0.0023	0.017	0.0296
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0018	0.009	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0109	0.1416	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0514	0.0538
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0018	0.009	0.0639
Trichomonas vaginalis	pten, drome, putative	0.0018	0.0095	0.0042
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.009	0.0095
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Loa Loa (eye worm)	RNA binding protein	0.0062	0.073	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0343	0.0597
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0018	0.0095	0.0099
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0078	0.0961	1
Plasmodium vivax	SET domain protein, putative	0.0059	0.069	0.7175
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0153	0.2064	0.2158
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Brugia malayi	Bromodomain containing protein	0.0148	0.1983	0.3454
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0241	0.1706
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0018	0.0095	0.0099
Leishmania major	metacaspase, putative	0.0078	0.0961	0.6789
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0101	0.0711
Giardia lamblia	PHD finger protein 15	0.0035	0.0346	0.0751
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0092	0.1173	0.1226
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0015	0.0053	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0078	0.0961	0.0913
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0018	0.0095	0.0099
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.011	0.0115
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0148	0.1988	0.2079
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0766	0.5408
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0148
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0018	0.009	0.0639
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0018	0.009	0.0038
Brugia malayi	Protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.1509	0.1578
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0148
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0018	0.0095	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Echinococcus granulosus	caspase 3	0.0071	0.0862	0.0902
Schistosoma mansoni	loxhd1	0.0038	0.0394	0.0412
Schistosoma mansoni	hypothetical protein	0.0012	0.0002	0.0002
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.3963	0.3932
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0374	0.0391
Schistosoma mansoni	zinc finger protein	0.004	0.0413	0.0432
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0017	0.0077	0.0081
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.011	0.0139
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.009	0.0158
Trypanosoma brucei	metacaspase 5, putative	0.0078	0.0961	0.6789
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.1852	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0153	0.2064	0.3595
Plasmodium falciparum	metacaspase-like protein	0.0078	0.0961	1
Schistosoma mansoni	rab6-interacting	0.0038	0.0394	0.0412
Echinococcus multilocularis	caspase 8	0.0078	0.0961	0.1005
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0018	0.0095	0.0669
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.011	0.0775
Schistosoma mansoni	caspase-7 (C14 family)	0.0198	0.271	0.2834
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0343	0.0359
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0165	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Echinococcus granulosus	dna polymerase eta	0.0019	0.011	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0079	0.0138
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0038	0.0394	0.0412
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Brugia malayi	Doublecortin family protein	0.0038	0.0394	0.0686
Onchocerca volvulus		0.0048	0.0534	0.0679
Schistosoma mansoni	hypothetical protein	0.003	0.0268	0.0281
Schistosoma mansoni	bromodomain containing protein	0.0125	0.1651	0.1727
Brugia malayi	hypothetical protein	0.0018	0.0095	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0019	0.011	0.0191
Trypanosoma brucei	Metacaspase-4	0.0078	0.0961	0.6789
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Echinococcus granulosus	dnaJ subfamily B	0.0398	0.5613	0.5869
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0085	0.0045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0343	0.0597
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0078	0.0961	0.0913
Echinococcus granulosus	cpg binding protein	0.0033	0.0318	0.0332
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.011	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.017	0.0118
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Brugia malayi	mbt repeat family protein	0.0047	0.0514	0.0895
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0241	0.0419
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0343	0.0358
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0033	0.0318	0.0333
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0018	0.0095	0.0042
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0018	0.0095	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.0092
Brugia malayi	Bromodomain containing protein	0.0075	0.092	0.1603
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0343	0.0291
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Brugia malayi	tumor suppressor.	0.0313	0.4378	0.7626
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0018	0.0095	0.0165
Onchocerca volvulus		0.0038	0.0394	0.0463
Trypanosoma brucei	metacaspase MCA3	0.0078	0.0961	0.6789
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0536	0.056
Loa Loa (eye worm)	hypothetical protein	0.008	0.0999	0.1741
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0534	0.0558
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0018	0.009	0.0095
Giardia lamblia	GTOR	0.0018	0.009	0.0097
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0024	0.0186	0.1313
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0343	0.1457
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0095	0.0099
Echinococcus multilocularis	RUN	0.0038	0.0394	0.0412
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0343	0.0901
Echinococcus multilocularis	caspase 3	0.0071	0.0862	0.0902
Echinococcus granulosus	CTD small phosphatase protein like	0.0015	0.0053	0.0055
Brugia malayi	RNA binding protein	0.0062	0.073	0.1271
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0085	0.5
Schistosoma mansoni	protein tyrosine phosphatase	0.0018	0.0095	0.0099
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0343	0.1457
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0018	0.0095	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0237	0.3271	0.5697
Echinococcus multilocularis	cpg binding protein	0.0033	0.0318	0.0332
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.0766	0.0717
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0058	0.006
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0766	0.5408
Schistosoma mansoni	hypothetical protein	0.0015	0.0058	0.006
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0018	0.0095	0.0165
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.3963	0.3932
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.017	0.0479
Plasmodium vivax	hypothetical protein, conserved	0.0078	0.0961	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0038	0.0394	0.0412
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.017	0.12
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.009	0.0639
Schistosoma mansoni	hypothetical protein	0.0035	0.0343	0.0359
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.073	0.0763
Plasmodium falciparum	phd finger protein, putative	0.0035	0.0346	0.3602
Toxoplasma gondii	exonuclease III APE	0.0018	0.0101	0.1047
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0018	0.0095	0.0042
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0056	0.065	0.0679
Echinococcus granulosus	peregrin	0.004	0.0413	0.0432
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0165	0.0113
Onchocerca volvulus		0.0048	0.0536	0.0683
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0346	0.3602
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.009	0.0095
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Mycobacterium ulcerans	lipase LipD	0.0035	0.0343	0.1457
Brugia malayi	hypothetical protein	0.0018	0.0095	0.0165
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Trypanosoma cruzi	ISWI complex protein	0.003	0.0268	0.1896
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	0.0015	0.0053	0.0055
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0343	0.0358
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0024	0.0186	0.0324
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0186	0.0134
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0018	0.0095	0.0099
Echinococcus multilocularis	serine protein kinase ATM	0.0024	0.0186	0.0194
Schistosoma mansoni	lipoxygenase	0.0108	0.1399	0.1463
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.017	0.12
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0095	0.0099
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0017	0.0077	0.0081
Leishmania major	hypothetical protein, conserved	0.0015	0.0053	0.0371
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0343	0.1027
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0137	0.0238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Brugia malayi	hypothetical protein	0.0018	0.0095	0.0165
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0078	0.0961	0.0913
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.017	0.0479
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0608	0.0636
Trypanosoma brucei	variant surface glycoprotein (VSG), putative	0.0109	0.1416	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.3963	0.3932
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0343	0.0291
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Echinococcus multilocularis		0.0018	0.0095	0.0099
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0891	0.1551
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.0766	0.0801
Brugia malayi	Protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0018	0.0095	0.0099
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0153	0.2064	0.2158
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.3963	0.3932
Entamoeba histolytica	hypothetical protein	0.0023	0.0165	0.0113
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0961	0.0913
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0018	0.009	0.0095
Onchocerca volvulus		0.0035	0.0343	0.0384
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0101	0.0711
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Brugia malayi	jmjC domain containing protein	0.0115	0.1509	0.2629
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0514	0.0895
Plasmodium vivax	metacaspase 1, putative	0.0078	0.0961	1
Giardia lamblia	Protein tyrosine phosphatase	0.0018	0.0095	0.0108
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.3271	0.342
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0092	0.1173	0.1226
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0078	0.0961	0.1674
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0343	0.242
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0046	0.0497	0.052
Entamoeba histolytica	hypothetical protein	0.0035	0.0343	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0109	0.1416	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.0346	0.0362
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0024	0.0186	0.1313
Onchocerca volvulus		0.0023	0.017	0.0116
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0085	0.0887
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0153	0.2064	0.2158
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.011	0.0775
Toxoplasma gondii	ABC1 family protein	0.0035	0.0343	0.3564
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0018	0.0095	0.0099
Plasmodium falciparum	LCCL domain-containing protein	0.0038	0.0394	0.4095
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0018	0.0095	0.0669
Trypanosoma brucei	unspecified product	0.0013	0.0024	0.0173
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0346	0.0362
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0018	0.0095	0.0042
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0241	0.0419
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.017	0.0479
Loa Loa (eye worm)	doublecortin family protein	0.0038	0.0394	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.017	0.0296
Echinococcus granulosus	lipoxygenase domain containing protein	0.0038	0.0394	0.0412
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.011	0.0775
Schistosoma mansoni	cpg binding protein	0.0033	0.0318	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.011	0.0191
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.069	0.0721
Schistosoma mansoni	DNA polymerase eta	0.0019	0.011	0.0115
Echinococcus multilocularis	peregrin	0.004	0.0413	0.0432
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0766	0.5408
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.011	0.0115
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0012	0.0002	0.0015
Brugia malayi	beta-lactamase family protein	0.0035	0.0343	0.0597
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0608	0.0636
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.011	0.0775
Schistosoma mansoni	zinc finger protein	0.003	0.0268	0.0281
Schistosoma mansoni	hypothetical protein	0.004	0.042	0.0439
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.0766	0.5408
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0101	0.0087
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.073	0.1271
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0078	0.0961	0.0913
Echinococcus granulosus	apoptotic protease activating factor 1	0.012	0.1584	0.1657
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.3078	1
Onchocerca volvulus		0.0038	0.0394	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0539	0.0939
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Echinococcus granulosus	caspase	0.0148	0.1988	0.2079
Onchocerca volvulus		0.0035	0.0343	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0922	0.1606
Schistosoma mansoni	hypothetical protein	0.0398	0.5613	0.5869
Echinococcus multilocularis	tumor protein p63	0.0329	0.4608	0.4819
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0109	0.1416	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0109	0.1416	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Brugia malayi	TAR-binding protein	0.0062	0.073	0.1271
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0101	0.0048
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.1509	0.1578
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0702	0.7301
Trichomonas vaginalis	esterase, putative	0.0035	0.0343	0.0291
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0343	0.0901
Brugia malayi	hypothetical protein	0.0237	0.3271	0.5697
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0046	0.0497	0.052
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0539	0.0939
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0101	0.0175
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0961	0.0913
Brugia malayi	PHD-finger family protein	0.0035	0.0346	0.0603
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0961	0.0913
Brugia malayi	F/Y-rich N-terminus family protein	0.0026	0.0211	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1066	0.1858
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.3271	0.342
Brugia malayi	Pre-SET motif family protein	0.0059	0.069	0.1201
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.017	0.0118
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0118	0.155	0.162
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0018	0.0091	0.0642
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.07	1	1
Trypanosoma brucei	unspecified product	0.0013	0.0024	0.0173
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.017	0.0479
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0018	0.0095	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0198	0.271	0.4722
Trypanosoma cruzi	ISWI complex protein	0.003	0.0268	0.1896
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Schistosoma mansoni	hypothetical protein	0.0288	0.4017	0.42
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0989	0.1723
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0343	0.0597
Echinococcus granulosus	lipoxygenase domain containing protein	0.0038	0.0394	0.0412
Entamoeba histolytica	hypothetical protein	0.0035	0.0343	0.0292
Schistosoma mansoni	hypothetical protein	0.0026	0.0219	0.0229
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0514	0.0538
Echinococcus multilocularis		0.0015	0.0053	0.0055
Echinococcus multilocularis	protein quaking	0.0026	0.0219	0.0229
Trypanosoma cruzi	metacaspase, putative	0.0078	0.0961	0.6789
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.009	0.0158
Loa Loa (eye worm)	jmjC domain-containing protein	0.0048	0.0531	0.0925
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0078	0.0961	0.0913
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.011	0.0115
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0608	0.0636
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0101	0.0711
Echinococcus multilocularis	zinc finger protein	0.004	0.0413	0.0432
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0343	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0087
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0058	0.0101
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0038	0.0394	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0534	0.093
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0407	0.5741	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0018	0.009	0.0639
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0343	0.0358
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.3963	0.3932
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0018	0.0095	0.0099
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0095	0.0099
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0018	0.009	0.0639
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0058	0.006
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0018	0.009	0.0639
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0058	0.006
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0018	0.0095	0.0099
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0018	0.0095	0.0099
Leishmania major	tyrosine specific protein phosphatase, putative	0.0018	0.0095	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.0546	0.0571
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0101	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0343	0.0597
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0018	0.0095	0.0099
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0018	0.0095	0.0099
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0514	0.0895
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0219	0.0382
Toxoplasma gondii	FATC domain-containing protein	0.0024	0.0186	0.1934
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0095	0.0099
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0346	0.3602
Schistosoma mansoni	cpg binding protein	0.0033	0.0318	0.0332
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0018	0.0095	0.0165
Brugia malayi	Temporarily assigned gene name protein 44	0.0026	0.0219	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0343	0.0597
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0343	0.0291
Trypanosoma brucei	hypothetical protein	0.0109	0.1416	1
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.008	0.0999	0.0952
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0109	0.1416	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0078	0.0961	0.0913
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0018	0.0095	0.0099
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0048	0.0531	0.0555
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0101	0.1047
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0343	0.3564
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Echinococcus granulosus	caspase 2	0.0198	0.271	0.2834
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.3963	0.3932
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.017	0.12
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Echinococcus granulosus	hypothetical protein	0.0026	0.0219	0.0229
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Brugia malayi	Importin beta-1 subunit	0.0028	0.0241	0.0421
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0018	0.0095	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Echinococcus granulosus	serine protein kinase ATM	0.0024	0.0186	0.0194
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.1852	0.5922
Echinococcus granulosus	RUN	0.0038	0.0394	0.0412
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0343	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0023	0.017	0.0296
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Schistosoma mansoni	hypothetical protein	0.012	0.1584	0.1657
Schistosoma mansoni	protein tyrosine phosphatase	0.0018	0.0095	0.0099
Echinococcus granulosus	microtubule associated protein 2	0.067	0.9563	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0241	0.2512
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0153	0.2064	0.3595
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0018	0.0095	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0023	0.017	0.0296
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0018	0.009	0.0639
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0343	0.0901
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.017	0.0479
Schistosoma mansoni	hypothetical protein	0.0334	0.469	0.4905
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0514	0.0649
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.073	0.1271
Schistosoma mansoni	hypothetical protein	0.0033	0.0316	0.0331
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0514	0.0538
Brugia malayi	RNA, U transporter 1	0.008	0.0991	0.1726
Loa Loa (eye worm)	tumor suppressor	0.0313	0.4378	0.7626
Brugia malayi	Protein-tyrosine phosphatase 1	0.0018	0.0095	0.0165
Brugia malayi	hypothetical protein	0.0038	0.0394	0.0686
Brugia malayi	Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1	0.0015	0.0053	0.0092
Echinococcus granulosus	dna polymerase kappa	0.0019	0.011	0.0115
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Echinococcus multilocularis	geminin	0.0334	0.469	0.4905
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0024	0.0173
Schistosoma mansoni	lipoxygenase	0.0038	0.0394	0.0412
Echinococcus multilocularis	caspase 2	0.0198	0.271	0.2834
Trypanosoma brucei	metacaspase MCA2	0.0078	0.0961	0.6789
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0092	0.1173	0.1226
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0101
Leishmania major	hypothetical protein, conserved	0.0035	0.0343	0.242
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0095	0.0099
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0343	0.1457
Plasmodium falciparum	importin beta, putative	0.0028	0.0241	0.2512
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0346	0.3602
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0058	0.006
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Echinococcus granulosus	tumor protein p63	0.0329	0.4608	0.4819
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0095	0.0099
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.009	0.0639
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0539	0.0939
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0346	0.0603
Schistosoma mansoni	protein tyrosine phosphatase	0.0018	0.0095	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0346	0.0603
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.3963	0.3932
Loa Loa (eye worm)	hypothetical protein	0.012	0.1584	0.276
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0148
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.017	0.0296
Plasmodium falciparum	metacaspase 1	0.0078	0.0961	1
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0018	0.0095	0.0099
Schistosoma mansoni	ap endonuclease	0.0018	0.0101	0.0105
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0018	0.0095	0.0099
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0241	0.2512
Schistosoma mansoni	hypothetical protein	0.0015	0.0058	0.006
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0153	0.2064	0.2158
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.3963	0.3932
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0101	0.0123
Schistosoma mansoni	hypothetical protein	0.0038	0.0394	0.0412
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.011	0.0191
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0012	0.0002	0.0015
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0018	0.009	0.0095
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0095	0.0099
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0514	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0961	0.1674
Brugia malayi	PHD-finger family protein	0.0017	0.0079	0.0138
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0608	0.0636
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0343	0.1027
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0536	0.0933
Onchocerca volvulus		0.0028	0.0241	0.0226
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.0766	0.1334
Trypanosoma brucei	calpain-like protein, putative	0.0109	0.1416	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0165	0.0113
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0961	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0148
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.009	0.0639
Echinococcus multilocularis	microtubule associated protein 2	0.067	0.9563	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0514	0.0538
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.011	0.0775
Onchocerca volvulus		0.0463	0.6555	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0101	0.0175
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0018	0.0095	0.0165
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0165	0.1163
Schistosoma mansoni	hypothetical protein	0.0015	0.0058	0.006
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Treponema pallidum	fructose-bisphosphate aldolase	0.0284	0.3963	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.011	0.0057
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0095	0.0099
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0021	0.0137	0.0966
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0012	0.0002	0.0022
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0078	0.0961	1
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0346	0.0362
Trypanosoma brucei	ISWI complex protein	0.003	0.0268	0.1896
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0148	0.1988	0.2079
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0343	0.0901
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0108	0.1399	0.1463
Schistosoma mansoni	caspase-7 (C14 family)	0.0148	0.1988	0.2079
Leishmania major	hypothetical protein, conserved	0.003	0.0268	0.1896
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0095	0.0165
Brugia malayi	hypothetical protein	0.0026	0.0219	0.0382
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.073	0.0763
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.3963	0.3932
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0018	0.009	0.0038
Schistosoma mansoni	hypothetical protein	0.0299	0.4174	0.4365
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.008	0.0999	0.0952
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0343	0.0597
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.011	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1839	0.3203
Loa Loa (eye worm)	bromodomain containing protein	0.0034	0.0336	0.0584
Schistosoma mansoni	pcd6 interacting protein-related	0.0018	0.0095	0.0099
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0033	0.0318	0.0333
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0018	0.009	0.0941
Onchocerca volvulus	Alhambra homolog	0.0035	0.0346	0.0389
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0018	0.0095	0.0669
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Brugia malayi	mbt repeat family protein	0.0047	0.0514	0.0895
Mycobacterium ulcerans	hypothetical protein	0.0023	0.017	0.0479
Trypanosoma brucei	Mitochondrial import inner membrane translocase subunit TIM50	0.0015	0.0053	0.0371
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.011	0.0775
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0241	0.0253
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Schistosoma mansoni	rab6-interacting	0.0038	0.0394	0.0412
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0109	0.1416	1
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.011	0.0139
Trichomonas vaginalis	set domain proteins, putative	0.0463	0.6555	0.6537
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Echinococcus multilocularis	dna polymerase eta	0.0019	0.011	0.0115
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0018	0.009	0.0639
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0018	0.0091	0.0642
Plasmodium vivax	hypothetical protein, conserved	0.0013	0.0027	0.0279
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0058	0.006
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Echinococcus granulosus	geminin	0.0334	0.469	0.4905
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Trypanosoma cruzi	metacaspase 5, putative	0.0078	0.0961	0.6789
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.011	0.0057
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.0766	0.0801
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0101	0.0711
Echinococcus multilocularis	caspase	0.0148	0.1988	0.2079
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0153	0.2064	0.2158
Trypanosoma cruzi	metacaspase 5, putative	0.0078	0.0961	0.6789
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.007	0.0853	0.0892
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0095	0.0165
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0343	0.0901
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.017	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Schistosoma mansoni	cpg binding protein	0.0028	0.0241	0.0252
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0018	0.0095	0.0099
Echinococcus granulosus	protein quaking	0.0026	0.0219	0.0229
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.0766	0.1334
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.009	0.0095
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0343	0.0901
Schistosoma mansoni	hypothetical protein	0.0334	0.469	0.4905
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0374	0.0391
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0118	0.155	0.162
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0033	0.0318	0.0333
Entamoeba histolytica	hypothetical protein	0.0035	0.0343	0.0292
Echinococcus multilocularis	apoptotic protease activating factor 1	0.012	0.1584	0.1657
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0109	0.1416	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0299	0.4174	0.7272
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0053	0.0371
Toxoplasma gondii	Dullard family phosphatase domain-containing protein	0.0015	0.0053	0.0547
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0109	0.1416	1
Brugia malayi	Cell death protein 3 precursor	0.0198	0.271	0.4722
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0241	0.1706
Loa Loa (eye worm)	MBCTL1	0.0053	0.0608	0.1059
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0343	0.242
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0078	0.0961	0.1005
Onchocerca volvulus		0.0035	0.0343	0.0384
Echinococcus granulosus	caspase 8	0.0078	0.0961	0.1005
Echinococcus granulosus	Polycystic kidney disease protein	0.0038	0.0394	0.0412
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.073	0.0763
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.011	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0095	0.0165
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0109	0.1416	1
Trypanosoma brucei	metacaspase	0.0078	0.0961	0.6789
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0343	0.1457
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0727	0.076
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0018	0.0095	0.0099
Loa Loa (eye worm)	hypothetical protein	0.006	0.0711	0.1239
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0058	0.0101
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.007	0.0853	0.0892
Onchocerca volvulus		0.0047	0.0514	0.0649
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0018	0.0095	0.0099
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0514	0.0538
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0018	0.009	0.0639
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0961	0.0913
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0085	0.0887
Entamoeba histolytica	hypothetical protein	0.0035	0.0343	0.0292
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0024	0.0173
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0095	0.0099
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0343	0.0901
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0078	0.0961	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Schistosoma mansoni	hypothetical protein	0.0015	0.005	0.0052
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0015	0.0053	0.0055
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0109	0.1416	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.073	0.0763
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.1165	0.1218
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.009	0.0038
Brugia malayi	hypothetical protein	0.0038	0.0394	0.0686
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0018	0.0095	0.0099

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 3.921 uM	PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120]	ChEMBL.	No reference
IC50 (functional)	= 6.67 uM	PUBCHEM_BIOASSAY: Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	= 7.43 uM	PUBCHEM_BIOASSAY: Dose Response selectivity of inhibitors of Striatal-Enriched Phosphatase (STEP) in a SHP2 (PTPN11) Inhibition Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	= 13.4 uM	PUBCHEM_BIOASSAY: Dose response confirmation of uHTS small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	26.3 uM	PubChem BioAssay. Dose response orthogonal assay of uHTS small molecule inhibitors of Striatal-Enriched Phosphatase via a colorimetric intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	100 uM	PubChem BioAssay. Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the Lymphoid Phosphatase (PTPN22) Inhibition Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1733383
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 722022