Detailed information for compound 725148

Basic information

Technical information
  • TDR Targets ID: 725148
  • Name: 1-naphthalen-2-ylsulfonylpiperidine-3-carboxa mide
  • MW: 318.391 | Formula: C16H18N2O3S
  • H donors: 1 H acceptors: 3 LogP: 1.69 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)C1CCCN(C1)S(=O)(=O)c1ccc2c(c1)cccc2
  • InChi: 1S/C16H18N2O3S/c17-16(19)14-6-3-9-18(11-14)22(20,21)15-8-7-12-4-1-2-5-13(12)10-15/h1-2,4-5,7-8,10,14H,3,6,9,11H2,(H2,17,19)
  • InChiKey: KHYDJJVNIIEUMP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-(2-naphthylsulfonyl)piperidine-3-carboxamide
  • 1-(2-naphthylsulfonyl)-3-piperidinecarboxamide
  • 1-(2-naphthylsulfonyl)nipecotamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0361 0.3363
Schistosoma mansoni ran 0.0021 0.0016 0.003
Entamoeba histolytica cysteine protease, putative 0.0034 0.0056 0.204
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1413 0.4519 0.4518
Onchocerca volvulus 0.0074 0.0187 0.1114
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0007 0.0004
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0056 0.0053
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.002 0.001 0.007
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0026 0.0031 0.1099
Schistosoma mansoni microtubule-associated protein tau 0.1374 0.4391 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0007 0.0034
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0074 0.0639
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0021 0.017
Brugia malayi latrophilin 2 splice variant baaae 0.0454 0.1416 0.6756
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0071 0.0384
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0021 0.017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0056 0.0296
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0016 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0031 0.0267
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0071 0.0068
Echinococcus granulosus neutral sphingomyelinase 0.002 0.001 0.0007
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0028 0.0025
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.021 0.0627 0.0624
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.011 0.1008
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0132 0.0293
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0404 0.0401
Plasmodium falciparum thrombospondin-related anonymous protein 0.0058 0.0134 0.5063
Mycobacterium tuberculosis Probable reductase 0.0172 0.0502 0.3343
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0104 0.0497
Schistosoma mansoni hypothetical protein 0.021 0.0627 0.1422
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.011 0.1008
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0056 0.0053
Plasmodium falciparum thioredoxin reductase 0.0026 0.0031 0.1099
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0021 0.0018
Schistosoma mansoni hypothetical protein 0.0534 0.1675 0.381
Trypanosoma brucei trypanothione reductase 0.0075 0.019 0.1761
Schistosoma mansoni hypothetical protein 0.021 0.0627 0.1422
Onchocerca volvulus 0.0034 0.0056 0.0285
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0058 0.0134 0.5063
Schistosoma mansoni alpha-glucosidase 0.0149 0.043 0.0972
Loa Loa (eye worm) glutaminase 0.0568 0.1785 0.8514
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0114 0.4282
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.011 0.1008
Loa Loa (eye worm) hypothetical protein 0.0025 0.0029 0.0107
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.0031 0.015
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0007 0.0008
Schistosoma mansoni carbon catabolite repressor protein 0.002 0.001 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0071 0.0384
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0056 0.204
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0058 0.0134 0.0131
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.001 0.005
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0016 0.0013
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0021 0.0018
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0664 0.2095 1
Trypanosoma brucei unspecified product 0.0023 0.0021 0.017
Mycobacterium tuberculosis Conserved protein 0.0074 0.0187 0.1202
Leishmania major cathepsin L-like protease 0.0034 0.0056 0.0462
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0056 0.0296
Leishmania major endonuclease/exonuclease protein-like protein 0.002 0.001 0.0036
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0041 0.0356
Schistosoma mansoni hypothetical protein 0.0058 0.0134 0.0298
Echinococcus multilocularis smad 0.0025 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0016 0.0077
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.001 0.0018
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0191 0.0564 0.3764
Echinococcus multilocularis geminin 0.0534 0.1675 0.1672
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0056 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0136
Loa Loa (eye worm) Smad1 0.0025 0.0028 0.0102
Schistosoma mansoni ap endonuclease 0.0097 0.0261 0.0588
Echinococcus multilocularis expressed protein 0.004 0.0078 0.0075
Echinococcus granulosus cathepsin l1 0.0034 0.0056 0.0053
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.0009 0.0043
Brugia malayi jmjC domain containing protein 0.0018 0.0007 0.0032
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0289
Brugia malayi hypothetical protein 0.0238 0.0717 0.3421
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.002 0.001 0.007
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.002 0.001 0.0036
Trypanosoma brucei protein kinase, putative 0.005 0.011 0.1008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0155 0.2829
Trichomonas vaginalis set domain proteins, putative 0.051 0.1597 0.8945
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0026 0.0031 0.0472
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.002 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0058 0.0306
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0071 0.1236
Trichomonas vaginalis mercuric reductase, putative 0.0026 0.0031 0.0159
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0029 0.1011
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.002 0.001 0.0007
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.001 0.007
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0187 0.1202
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0029 0.0428
Schistosoma mansoni ran 0.0021 0.0016 0.003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0097 0.0261 0.2426
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.002 0.001 0.0017
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0132 0.4987
Loa Loa (eye worm) hypothetical protein 0.0074 0.0187 0.0865
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0097 0.0261 0.1361
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0105 0.0954
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0187 0.1202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0058 0.0306
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0074 0.0671
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0513 0.245
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0134 0.5063
Toxoplasma gondii hypothetical protein 0.0056 0.0128 0.231
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0683 0.2158 0.4911
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0111 0.0245
Brugia malayi AF-10 protein 0.0019 0.0007 0.0035
Mycobacterium tuberculosis Conserved hypothetical protein 0.0182 0.0537 0.358
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.002 0.001 0.007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0187 0.0552 0.0549
Brugia malayi von Willebrand Factor 0.0058 0.0134 0.0638
Leishmania major hypothetical protein, conserved 0.002 0.001 0.0036
Trichomonas vaginalis glutaminase, putative 0.0568 0.1785 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.018 0.0531 0.0528
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.0531 0.289
Leishmania major mitochondrial DNA polymerase beta 0.0346 0.1067 1
Echinococcus multilocularis traf and tnf receptor associated protein 0.002 0.001 0.0007
Plasmodium falciparum DNase I-like protein, putative 0.002 0.001 0.0289
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0404 0.0401
Brugia malayi von Willebrand factor type A domain containing protein 0.0058 0.0134 0.0638
Trichomonas vaginalis CMGC family protein kinase 0.005 0.011 0.0602
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0187 0.7136
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.001 0.005
Loa Loa (eye worm) hypothetical protein 0.0064 0.0155 0.071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0404 0.0401
Onchocerca volvulus 0.0058 0.0134 0.0777
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0097 0.0261 1
Toxoplasma gondii aldehyde dehydrogenase 0.018 0.0531 1
Echinococcus granulosus dna polymerase eta 0.0023 0.0021 0.0018
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0071 0.0611
Plasmodium falciparum glutathione reductase 0.0075 0.019 0.726
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0097 0.0261 1
Trichomonas vaginalis esterase, putative 0.0074 0.0187 0.1034
Echinococcus multilocularis lamin 0.0028 0.0038 0.0035
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.002 0.001 0.0289
Loa Loa (eye worm) thioredoxin reductase 0.0075 0.019 0.088
Onchocerca volvulus 0.0058 0.0134 0.0777
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0171 0.0382
Echinococcus granulosus Smad4 0.0025 0.0028 0.0025
Brugia malayi jmjC domain containing protein 0.0069 0.0171 0.0814
Plasmodium falciparum importin beta, putative 0.0029 0.0041 0.1468
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0021 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0404 0.0913
Brugia malayi von Willebrand factor type A domain containing protein 0.0058 0.0134 0.0638
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.001 0.007
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0028 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.002 0.0094
Plasmodium vivax exodeoxyribonuclease III, putative 0.002 0.001 0.0289
Trypanosoma cruzi cruzipain precursor, putative 0.0128 0.0361 0.3363
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0289
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.018 0.0531 0.4942
Echinococcus multilocularis thioredoxin glutathione reductase 0.0076 0.0194 0.0191
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0016 0.0123
Brugia malayi MH1 domain containing protein 0.0025 0.0028 0.0134
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0147 0.0144
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0164 0.0477 0.4456
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0026 0.0031 0.0142
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0096 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0021 0.017
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.002 0.001 0.0289
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0171 0.0168
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0007 0.0014
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.0031 0.0267
Trichomonas vaginalis CMGC family protein kinase 0.005 0.011 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0065 0.035
Echinococcus granulosus microtubule associated protein 2 0.1374 0.4391 0.4389
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0071 0.0384
Schistosoma mansoni aldehyde dehydrogenase 0.018 0.0531 0.1203
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0155 0.0152
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0058 0.0972
Echinococcus multilocularis cysteine protease 0.0034 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0063
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0021 0.0041
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.002 0.001 0.0007
Leishmania major cathepsin L-like protease 0.0034 0.0056 0.0462
Brugia malayi CCR4 0.002 0.001 0.005
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0007 0.0004
Echinococcus multilocularis neutral sphingomyelinase 0.002 0.001 0.0007
Schistosoma mansoni lamin 0.0028 0.0038 0.0079
Plasmodium vivax vivapain-2 0.0034 0.0056 0.204
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0073
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0023 0.0113
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0117 0.0325 0.3025
Brugia malayi Calcitonin receptor-like protein seb-1 0.0664 0.2095 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0044 0.0228
Brugia malayi RNA, U transporter 1 0.0083 0.0214 0.1021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0031 0.0233
Loa Loa (eye worm) hypothetical protein 0.021 0.0627 0.2969
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0004
Loa Loa (eye worm) latrophilin receptor protein 2 0.021 0.0627 0.2969
Loa Loa (eye worm) hypothetical protein 0.0098 0.0264 0.1231
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0097 0.0261 0.0258
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Brugia malayi Cathepsin L-like precursor 0.0034 0.0056 0.0266
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.011 0.0107
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.001 0.0018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0021 0.0072
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0074 0.2767
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0056 0.204
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0204 0.0201
Leishmania major cathepsin L-like protease 0.0034 0.0056 0.0462
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.01 0.3558
Mycobacterium ulcerans hypothetical protein 0.0182 0.0537 0.2926
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0056 0.0053
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.002 0.001 0.0042
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0074 0.0671
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0021 0.017
Loa Loa (eye worm) hypothetical protein 0.0074 0.0187 0.0865
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0096 0.0871
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.002 0.001 0.007
Echinococcus multilocularis voltage dependent calcium channel subunit 0.3107 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0036 0.0184
Echinococcus multilocularis musashi 0.0028 0.0038 0.0035
Brugia malayi MH1 domain containing protein 0.0025 0.0028 0.0134
Echinococcus granulosus snurportin 1 0.031 0.0949 0.0946
Schistosoma mansoni serine/threonine protein kinase 0.005 0.011 0.0245
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0007 0.0171
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.0031 0.0233
Schistosoma mansoni glutaminase 0.0568 0.1785 0.4061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0056 0.0296
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0155 0.0346
Entamoeba histolytica elongation factor-2 kinase, putative 0.0058 0.0134 0.5063
Schistosoma mansoni alpha-glucosidase 0.0149 0.043 0.0972
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0073
Schistosoma mansoni synaptojanin 0.002 0.001 0.0017
Brugia malayi von Willebrand factor type A domain containing protein 0.0058 0.0134 0.0638
Brugia malayi exodeoxyribonuclease III family protein 0.0097 0.0261 0.1247
Onchocerca volvulus 0.0049 0.0104 0.059
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.002 0.001 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0187 0.1202
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0105 0.0954
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0187 0.1034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0036 0.0184
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0007 0.0008
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.001 0.007
Loa Loa (eye worm) cysteine protease 0.0034 0.0056 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0361 0.3363
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0021 0.017
Onchocerca volvulus 0.0034 0.0056 0.0285
Loa Loa (eye worm) hypothetical protein 0.0074 0.0187 0.0865
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0016 0.0123
Toxoplasma gondii microneme protein MIC2 0.0058 0.0134 0.2424
Echinococcus granulosus tar DNA binding protein 0.0069 0.0171 0.0168
Brugia malayi Bromodomain containing protein 0.0061 0.0146 0.0695
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0016 0.0123
Schistosoma mansoni lamin 0.0028 0.0038 0.0079
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1356 0.4333 0.9867
Trichomonas vaginalis Phospholipase C precursor, putative 0.002 0.001 0.0042
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0073
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0187 0.1034
Leishmania major cathepsin L-like protease 0.0034 0.0056 0.0462
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0028 0.0025
Schistosoma mansoni hypothetical protein 0.0534 0.1675 0.381
Schistosoma mansoni smad1 5 8 and 0.0025 0.0028 0.0057
Plasmodium vivax hypothetical protein, conserved 0.002 0.001 0.0289
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.011 0.0977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0097 0.0261 0.2426
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0171 0.0786
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0007 0.0008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0404 0.1901
Plasmodium vivax vivapain-2 0.0034 0.0056 0.204
Toxoplasma gondii thioredoxin reductase 0.0075 0.019 0.3506
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.001 0.0042
Brugia malayi jmjC domain containing protein 0.0187 0.0552 0.2635
Echinococcus granulosus tumor protein p63 0.0346 0.1065 0.1062
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.002 0.001 0.0042
Schistosoma mansoni hypothetical protein 0.021 0.0627 0.1422
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0021 0.017
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0187 0.0184
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.001 0.005
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0171 0.0382
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0097 0.0261 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0508 0.0505
Entamoeba histolytica hypothetical protein 0.0024 0.0023 0.0781
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.018 0.0531 0.0528
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.2587 0.2585
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0626 0.1971 0.9405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Brugia malayi jmjC domain containing protein 0.0018 0.0007 0.0032
Echinococcus granulosus thioredoxin glutathione reductase 0.0076 0.0194 0.0191
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.0531 0.289
Echinococcus granulosus phd:f box containing protein 0.0018 0.0007 0.0004
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.0031 0.0233
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0346 0.1067 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0187 0.042
Brugia malayi Zona pellucida-like domain containing protein 0.0058 0.0134 0.0638
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0171 0.0786
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.001 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0056 0.0296
Loa Loa (eye worm) CUTiclin family member 0.0058 0.0134 0.0608
Plasmodium falciparum thioredoxin reductase 0.0075 0.019 0.726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0361 0.3363
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0021 0.0102
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0026 0.0031 0.1099
Giardia lamblia PHD finger protein 15 0.0057 0.0132 0.4837
Brugia malayi MH2 domain containing protein 0.0367 0.1135 0.5419
Onchocerca volvulus 0.0153 0.0443 0.2726
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0105 0.0954
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0361 0.3363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0155 0.0346
Entamoeba histolytica hypothetical protein, conserved 0.0058 0.0134 0.5063
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0187 0.0552 0.0549
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0028 0.0102
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0071 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0058 0.0306
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0023 0.0189
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0717 0.0714
Giardia lamblia Kinase, CMGC MAPK 0.005 0.011 0.3983
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.2878 0.9257 1
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.002 0.001 0.0042
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.001 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0074 0.0398
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0021 0.0136
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0021 0.017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0071 0.0384
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0021 0.0102
Brugia malayi Cathepsin L-like precursor 0.0034 0.0056 0.0266
Brugia malayi von Willebrand factor type A domain containing protein 0.0058 0.0134 0.0638
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0187 0.1202
Trypanosoma cruzi trypanothione reductase, putative 0.0075 0.019 0.1761
Trichomonas vaginalis CMGC family protein kinase 0.005 0.011 0.0602
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0187 0.1731
Loa Loa (eye worm) hypothetical protein 0.0664 0.2095 1
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0018
Brugia malayi Cache domain containing protein 0.0626 0.1971 0.9407
Loa Loa (eye worm) hypothetical protein 0.0153 0.0443 0.2089
Echinococcus multilocularis peregrin 0.0061 0.0146 0.0143
Loa Loa (eye worm) fibroinase 0.0034 0.0056 0.0235
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.001 0.0289
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0664 0.2095 1
Onchocerca volvulus 0.0034 0.0056 0.0285
Brugia malayi Cathepsin L-like precursor 0.0034 0.0056 0.0266
Trichomonas vaginalis ran, putative 0.0021 0.0016 0.0074
Echinococcus multilocularis snurportin 1 0.031 0.0949 0.0946
Plasmodium vivax SET domain protein, putative 0.0064 0.0155 0.5885
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0404 0.0913
Schistosoma mansoni intermediate filament proteins 0.0028 0.0038 0.0079
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0497 0.0495
Schistosoma mansoni hypothetical protein 0.0019 0.0007 0.001
Onchocerca volvulus 0.0058 0.0134 0.0777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0136
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0134 0.0638
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0015 0.0072
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0132 0.0129
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.011 0.0107
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0289
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0056 0.0266
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.002 0.001 0.0036
Echinococcus granulosus intermediate filament protein 0.0028 0.0038 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0021 0.017
Toxoplasma gondii cathepsin CPL 0.0034 0.0056 0.0935
Onchocerca volvulus 0.0028 0.0038 0.0172
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0038 0.0149
Brugia malayi jmjC domain containing protein 0.0018 0.0007 0.0032
Giardia lamblia NADH oxidase lateral transfer candidate 0.0026 0.0031 0.0834
Mycobacterium tuberculosis Conserved protein 0.0074 0.0187 0.1202
Onchocerca volvulus 0.0074 0.0187 0.1114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0047 0.0246
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0056 0.204
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Plasmodium vivax JmjC domain containing protein 0.0018 0.0007 0.0142
Trypanosoma cruzi mitochondrial protein 99, putative 0.002 0.001 0.007
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0105 0.0954
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0031 0.0267
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.002 0.001 0.0042
Giardia lamblia GTOR 0.0046 0.0096 0.3399
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0021 0.0101
Trypanosoma brucei RNA editing exonuclease 2 0.002 0.001 0.007
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.011 0.0977
Onchocerca volvulus Alhambra homolog 0.0057 0.0132 0.0765
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0058 0.0134 0.0734
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0058 0.0134 0.5063
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0016 0.0226
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.01 0.3744
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.001 0.005
Loa Loa (eye worm) acetyltransferase 0.0175 0.0513 0.2426
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.0508 0.0505
Schistosoma mansoni jumonji domain containing protein 0.0149 0.0428 0.0968
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0361 0.3363
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0056 0.0296
Mycobacterium ulcerans beta-lactamase 0.0074 0.0187 0.0942
Echinococcus multilocularis Smad4 0.0025 0.0028 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0056 0.0296
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0071 0.0643
Loa Loa (eye worm) hypothetical protein 0.0454 0.1416 0.6746
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0346 0.1067 1
Echinococcus multilocularis lamin dm0 0.0028 0.0038 0.0035
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0058 0.0134 0.0608
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0096 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0136
Echinococcus granulosus mitogen activated protein kinase 0.005 0.011 0.0107
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0069
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0031 0.0267
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.001 0.0289
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.001 0.0042
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0056 0.012
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.0031 0.0058
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.021 0.0627 0.0624
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0096 0.359
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0065 0.035
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0114 0.062
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0132 0.0129
Leishmania major cathepsin L-like protease 0.0128 0.0361 0.334
Trichomonas vaginalis glutathione reductase, putative 0.0026 0.0031 0.0159
Schistosoma mansoni hypothetical protein 0.073 0.2308 0.5254
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0015 0.0027
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0078 0.037
Schistosoma mansoni importin beta-1 0.0029 0.0041 0.0086
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0007 0.0004
Brugia malayi Cathepsin L-like precursor 0.0034 0.0056 0.0266
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0071 0.0643
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.0031 0.0028
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.001 0.005
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0114 0.2039
Schistosoma mansoni hypothetical protein 0.0049 0.0104 0.023
Brugia malayi von Willebrand factor type A domain containing protein 0.0058 0.0134 0.0638
Mycobacterium ulcerans hypothetical protein 0.0074 0.0187 0.0942
Brugia malayi Cathepsin L-like precursor 0.0022 0.002 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0036 0.0184
Schistosoma mansoni smad 0.0025 0.0028 0.0057
Echinococcus granulosus collagen alpha 1VII chain 0.0058 0.0134 0.0131
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0097 0.0261 0.2426
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.001 0.005
Leishmania major GTP-binding protein, putative 0.0021 0.0016 0.0089
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0003 0.0014
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0056 0.0235
Mycobacterium ulcerans glutaminase 0.0568 0.1785 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0026 0.0031 0.1099
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0171 0.0382
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0021 0.0101
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0187 0.1034
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0056 0.204
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0007 0.0171
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0031 0.0267
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.0328 0.1541
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0009 0.0054
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0031 0.0267
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.0009 0.0043
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0056 0.012
Onchocerca volvulus 0.0074 0.0187 0.1114
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0029 0.1011
Brugia malayi hypothetical protein 0.0153 0.0443 0.2114
Schistosoma mansoni smad1 5 8 and 0.0025 0.0028 0.0057
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0096 0.0871
Onchocerca volvulus 0.0058 0.0134 0.0777
Loa Loa (eye worm) glutathione reductase 0.0075 0.019 0.088
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.002 0.001 0.0289
Treponema pallidum exodeoxyribonuclease (exoA) 0.0097 0.0261 0.0271
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0114 0.062
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0155 0.0152
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0141
Brugia malayi hypothetical protein 0.0058 0.0134 0.0638
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0029 0.0245
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0017 0.0135
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0114 0.0111
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0073
Loa Loa (eye worm) transcription factor SMAD2 0.0367 0.1135 0.5405
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0073
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0007 0.0034
Schistosoma mansoni aldehyde dehydrogenase 0.018 0.0531 0.1203
Schistosoma mansoni Smad4 0.0025 0.0028 0.0057
Brugia malayi Cathepsin L-like precursor 0.0022 0.002 0.0094
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0097 0.0261 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.002 0.001 0.007
Onchocerca volvulus 0.0064 0.0155 0.0911
Echinococcus granulosus geminin 0.0534 0.1675 0.1672
Leishmania major pantothenate kinase subunit, putative 0.002 0.001 0.0036
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0289
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.002 0.0094
Trypanosoma cruzi pantothenate kinase subunit, putative 0.002 0.001 0.007
Entamoeba histolytica hypothetical protein, conserved 0.0058 0.0134 0.5063
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0171 0.0382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0361 0.3363
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0031 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0065 0.035
Brugia malayi Latrophilin receptor protein 2 0.021 0.0627 0.2991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Brugia malayi jmjC domain containing protein 0.0018 0.0007 0.0032
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0139 0.1278
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0097 0.0261 1
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0018
Echinococcus multilocularis GPCR, family 2 0.021 0.0627 0.0624
Brugia malayi von Willebrand factor type A domain containing protein 0.0058 0.0134 0.0638
Onchocerca volvulus 0.0034 0.0056 0.0285
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0346 0.1067 1
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0041 0.0038
Onchocerca volvulus 0.01 0.0271 0.1644
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0007 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0056 0.204
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0021 0.0072
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0096 0.0871
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0155 0.0152
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0063
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.011 0.0107
Mycobacterium tuberculosis Probable oxidoreductase 0.0191 0.0564 0.3764
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0021 0.017
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0187 0.1034
Entamoeba histolytica hypothetical protein 0.0058 0.0134 0.5063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0136
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.002 0.001 0.007
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0065 0.0586
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0097 0.0261 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.0031 0.0058
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.002 0.001 0.0018
Treponema pallidum 76K protein 0.0058 0.0134 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0136
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.001 0.0289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0361 0.3363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0096 0.052
Brugia malayi Pre-SET motif family protein 0.0448 0.1397 0.6666
Loa Loa (eye worm) hypothetical protein 0.0238 0.0717 0.34
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0021 0.017
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.0531 0.289
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0021 0.017
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0172 0.0502 0.8356
Loa Loa (eye worm) MH2 domain-containing protein 0.0367 0.1135 0.5405
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0.0031 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0404 0.1927
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0187 0.0942
Leishmania major cathepsin L-like protease 0.0128 0.0361 0.334
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.001 0.0018
Echinococcus multilocularis cysteine protease 0.0034 0.0056 0.0053
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.018 0.0531 0.3537
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0058 0.0134 0.5063
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0171 0.0168
Trypanosoma cruzi mitochondrial protein 99, putative 0.002 0.001 0.007
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0016 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0096 0.052
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0096 0.0426
Loa Loa (eye worm) CUTiclin-Like family member 0.0058 0.0134 0.0608
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0056 0.0285
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0717 0.0714
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0007 0.0004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0171 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0035 0.018
Onchocerca volvulus 0.0034 0.0056 0.0285
Echinococcus multilocularis deoxyribonuclease 1 2 0.002 0.001 0.0007
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.002 0.001 0.007
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.011 0.1978
Leishmania major DNA polymerase kappa, putative 0.0023 0.0021 0.0136
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0007 0.0041
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0031 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0155 0.0346
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0071 0.031
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0031 0.0267
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0071 0.0384
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0171 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0065 0.035
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0114 0.2039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0056 0.0296
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0096 0.0457
Schistosoma mansoni alpha glucosidase 0.0038 0.0071 0.0156
Toxoplasma gondii exonuclease III APE 0.0097 0.0261 0.4855
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0058 0.0134 0.5063
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0187 0.1034
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0171 0.0382
Leishmania major hypothetical protein, conserved 0.002 0.001 0.0036
Onchocerca volvulus 0.0034 0.0056 0.0285
Loa Loa (eye worm) beta-lactamase 0.0074 0.0187 0.0865
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0056 0.0296
Onchocerca volvulus 0.0022 0.002 0.0059
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0097 0.0261 0.24
Leishmania major RNA-editing complex protein MP100, putative 0.002 0.001 0.0036
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0016 0.0508
Trichomonas vaginalis ap endonuclease, putative 0.0097 0.0261 0.1449
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0071 0.0384
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0474 0.1482 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0031 0.0233
Loa Loa (eye worm) hypothetical protein 0.0057 0.0132 0.0599
Plasmodium falciparum glutathione reductase 0.0026 0.0031 0.1099
Brugia malayi Thioredoxin reductase 0.0075 0.019 0.0909
Plasmodium falciparum phd finger protein, putative 0.0057 0.0132 0.4987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0035 0.018
Trichomonas vaginalis rotamase, putative 0.004 0.0078 0.0418
Echinococcus granulosus peregrin 0.0061 0.0146 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0404 0.0401
Loa Loa (eye worm) hypothetical protein 0.0074 0.0187 0.0865
Brugia malayi RNA binding protein 0.0069 0.0171 0.0815
Brugia malayi Zona pellucida-like domain containing protein 0.0058 0.0134 0.0638
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0187 0.1202
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0071 0.2651
Leishmania major importin beta-1 subunit, putative 0.0024 0.0023 0.0156
Treponema pallidum NADH oxidase 0.0026 0.0031 0.0023
Onchocerca volvulus 0.0058 0.0134 0.0777
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0096 0.0093
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0096 0.359
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.002 0.001 0.0007
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0028 0.0025
Leishmania major DNA polymerase eta, putative 0.0023 0.0021 0.0136
Trichomonas vaginalis CMGC family protein kinase 0.005 0.011 0.0602
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.002 0.001 0.007
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0017
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0096 0.0839
Schistosoma mansoni smad1 5 8 and 0.0025 0.0028 0.0057
Mycobacterium tuberculosis Probable dehydrogenase 0.0172 0.0502 0.3343
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0003 0.0014
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0016 0.0508
Brugia malayi MH2 domain containing protein 0.0025 0.0028 0.0134
Trypanosoma brucei glucosidase, putative 0.0038 0.0071 0.0643
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0074 0.1293
Giardia lamblia DINP protein human, muc B family 0.0023 0.0021 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0021 0.017
Schistosoma mansoni nocturnin 0.002 0.001 0.0017
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0361 0.3363
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0071 0.0384
Echinococcus granulosus endonuclease exonuclease phosphatase 0.002 0.001 0.0007
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0132 0.0599
Loa Loa (eye worm) hypothetical protein 0.0074 0.0187 0.0865
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0172 0.0502 0.3343
Brugia malayi PHD-finger family protein 0.0019 0.0007 0.0035
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.002 0.001 0.0289
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0073
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0021 0.017
Onchocerca volvulus 0.051 0.1597 1
Brugia malayi hypothetical protein 0.0025 0.0029 0.0139
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0026 0.0031 0.1099
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0204 0.0201
Schistosoma mansoni ap endonuclease 0.0097 0.0261 0.0588
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0065 0.0554
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Echinococcus granulosus lamin dm0 0.0028 0.0038 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0361 0.3363
Plasmodium vivax importin-beta 2, putative 0.0029 0.0041 0.1468
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0361 0.3363
Brugia malayi beta-lactamase 0.0074 0.0187 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0096 0.052
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.0949 0.4513
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0031 0.0267
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0097 0.0261 0.1219
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0187 0.0942
Leishmania major hypothetical protein, conserved 0.0074 0.0187 0.1702
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0038 0.018
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.0031 0.0028
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0029 0.0245
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.001 0.007
Schistosoma mansoni rotamase 0.004 0.0078 0.017
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0164 0.0477 0.4456
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0361 0.3363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0155 0.0346
Leishmania major cathepsin L-like protease 0.0034 0.0056 0.0462
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.001 0.007
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.0031 0.0065
Mycobacterium tuberculosis Conserved protein 0.0074 0.0187 0.1202
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0171 0.0785
Brugia malayi Pre-SET motif family protein 0.0064 0.0155 0.074
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0023 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0361 0.3363
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0016 0.0181
Loa Loa (eye worm) ctsf protein 0.0034 0.0056 0.0235
Onchocerca volvulus 0.0051 0.0111 0.0631
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.0031 0.0267
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0056 0.0462
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.001 0.005
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0007 0.0014
Schistosoma mansoni hypothetical protein 0.0058 0.0134 0.0298
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0164 0.0477 0.4437
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0029 0.1011
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Echinococcus granulosus smad 0.0025 0.0028 0.0025
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0187 0.0894
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0065 0.0586
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.002 0.001 0.0007
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0058 0.0134 0.5063
Schistosoma mansoni DNA polymerase eta 0.0023 0.0021 0.0041
Echinococcus multilocularis synaptojanin 1 0.002 0.001 0.0007
Echinococcus multilocularis tumor protein p63 0.0346 0.1065 0.1062
Schistosoma mansoni neutral sphingomyelinase 0.002 0.001 0.0017
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0513 0.051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0041 0.0164
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0023 0.0113
Schistosoma mansoni hypothetical protein 0.0057 0.0132 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0361 0.3363
Brugia malayi von Willebrand factor type A domain containing protein 0.0058 0.0134 0.0638
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0149
Plasmodium vivax thioredoxin reductase, putative 0.0075 0.019 0.726
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0056 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0031 0.0267
Echinococcus granulosus expressed protein 0.004 0.0078 0.0075
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0289
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.001 0.0289
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0056 0.0053
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0007 0.0004
Brugia malayi TAR-binding protein 0.0069 0.0171 0.0815
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Echinococcus granulosus traf and tnf receptor associated protein 0.002 0.001 0.0007
Loa Loa (eye worm) RNA binding protein 0.0069 0.0171 0.0786
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0191 0.0564 0.3764
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0056 0.0296
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.0272 0.253
Loa Loa (eye worm) glutaminase 2 0.0568 0.1785 0.8514
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0056 0.0296
Brugia malayi glutathione reductase 0.0075 0.019 0.0909
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.001 0.007
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.011 0.1008
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0187 0.1202
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0071 0.0068
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0171 0.0382
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0171 0.0815
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0187 0.0184
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0029 0.0245
Brugia malayi PHD-finger family protein 0.0057 0.0132 0.0629
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0021 0.0018
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.001 0.007
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0508 0.0505
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.001 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0021 0.017
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.001 0.005
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0172 0.0502 0.3343
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0075 0.019 0.1223
Toxoplasma gondii ABC1 family protein 0.0074 0.0187 0.3445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0065 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Brugia malayi Importin beta-1 subunit 0.0029 0.0041 0.0195
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0096 0.0839
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0021 0.0069
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0021 0.0041
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0096 0.0871
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.0031 0.0267
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0007 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0021 0.017
Treponema pallidum hypothetical protein 0.0058 0.0134 0.0133
Leishmania major trypanothione reductase 0.0075 0.019 0.1733
Brugia malayi beta-lactamase family protein 0.0074 0.0187 0.0894
Trichomonas vaginalis rotamase, putative 0.0039 0.0074 0.0401
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.001 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0058 0.0306
Brugia malayi glutaminase DH11.1 0.0568 0.1785 0.8519
Brugia malayi Cathepsin L-like precursor 0.0034 0.0056 0.0266
Schistosoma mansoni survival motor neuron protein 0.0049 0.0104 0.023
Brugia malayi MAP kinase sur-1 0.005 0.011 0.0527
Schistosoma mansoni synaptojanin 0.002 0.001 0.0017
Onchocerca volvulus 0.0058 0.0134 0.0777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0058 0.0306
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0191 0.0564 1
Brugia malayi beta-lactamase family protein 0.0074 0.0187 0.0894
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0187 0.1202
Leishmania major hypothetical protein, conserved 0.0025 0.0029 0.0212
Echinococcus multilocularis dna polymerase eta 0.0023 0.0021 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0021 0.017
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0007 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0021 0.017
Loa Loa (eye worm) hypothetical protein 0.0051 0.0111 0.0498
Echinococcus multilocularis microtubule associated protein 2 0.1374 0.4391 0.4389
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0058 0.0134 0.0608
Brugia malayi intermediate filament protein 0.0028 0.0038 0.018
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0038 0.0149
Mycobacterium ulcerans lipase LipD 0.0074 0.0187 0.0942
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.0508 0.2423
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0041 0.0356
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0007 0.0142
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0074 0.0671
Leishmania major hypothetical protein, conserved 0.002 0.001 0.0036
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0041 0.0653
Onchocerca volvulus 0.0058 0.0134 0.0777
Plasmodium vivax glutathione reductase, putative 0.0075 0.019 0.726
Brugia malayi Smad1 0.0025 0.0028 0.0134
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0028 0.0025
Echinococcus granulosus cathepsin l1 0.0022 0.002 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0404 0.0913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0136
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.002 0.0649
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.002 0.001 0.0289
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.011 0.0496
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0021 0.017
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.021 0.0627 0.2991
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.021 0.0627 0.0624
Loa Loa (eye worm) hypothetical protein 0.0074 0.0187 0.0865
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.001 0.0289
Loa Loa (eye worm) hypothetical protein 0.0034 0.0056 0.0235
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0007 0.0008
Leishmania major cathepsin L-like protease 0.0128 0.0361 0.334
Brugia malayi MH2 domain containing protein 0.0025 0.0028 0.0134
Entamoeba histolytica Ran family GTPase 0.0021 0.0016 0.0508
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0172 0.0502 0.3343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0361 0.3363
Brugia malayi cathepsin L-like precursor 0.0022 0.002 0.0094
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0071 0.0384
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0063
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0097 0.0261 0.1704
Echinococcus granulosus synaptojanin 1 0.002 0.001 0.0007
Echinococcus granulosus GPCR family 2 0.021 0.0627 0.0624
Toxoplasma gondii NADPH-glutathione reductase 0.0026 0.0031 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0058 0.0306
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0021 0.0702
Echinococcus granulosus dna polymerase kappa 0.0023 0.0021 0.0018
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0071 0.0341
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.0508 0.2399
Echinococcus granulosus importin subunit beta 1 0.0029 0.0041 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0056 0.0296
Onchocerca volvulus 0.0034 0.0056 0.0285
Onchocerca volvulus 0.0028 0.0038 0.0172
Schistosoma mansoni cript-related 0.002 0.001 0.0017
Echinococcus granulosus lamin 0.0028 0.0038 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0187 0.042
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.011 0.1008
Brugia malayi von Willebrand factor type A domain containing protein 0.0058 0.0134 0.0638
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0136
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0007 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0078 0.0418
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0513 0.1163
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0058 0.0134 0.0638
Plasmodium vivax thrombospondin-related anonymous protein 0.0058 0.0134 0.5063
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0448 0.1397 0.6655
Schistosoma mansoni hypothetical protein 0.031 0.0949 0.2156
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0187 0.1731
Loa Loa (eye worm) hypothetical protein 0.0058 0.0134 0.0608
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0028 0.0102
Entamoeba histolytica sphingomyelinase C precursor, putative 0.002 0.001 0.0289
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0058 0.0134 0.2424
Echinococcus granulosus voltage dependent calcium channel subunit 0.1413 0.4519 0.4518
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0187 0.0865
Schistosoma mansoni hypothetical protein 0.0454 0.1416 0.3219
Schistosoma mansoni hypothetical protein 0.021 0.0627 0.1422
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.001 0.007
Trichomonas vaginalis ap endonuclease, putative 0.0097 0.0261 0.1449
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0056 0.0296
Plasmodium falciparum exodeoxyribonuclease III, putative 0.002 0.001 0.0289
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.0031 0.0058
Brugia malayi Cathepsin L-like precursor 0.0034 0.0056 0.0266
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.001 0.007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.021 0.0627 0.0624
Schistosoma mansoni serine-rich repeat protein 0.073 0.2308 0.5254
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.002 0.001 0.0042
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0071 0.2651
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0132 0.2386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0058 0.0306
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.01 0.3744
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0172 0.0502 0.3343
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0187 0.1731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.002 0.0094
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0056 0.0285
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.001 0.0018
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0056 0.0235
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0056 0.0285
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0078 0.0339
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0132 0.2386

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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