Detailed information for compound 79217

Basic information

Technical information
  • TDR Targets ID: 79217
  • Name: 6-[(3-methoxyanilino)methyl]pyrido[3,2-d]pyri midine-2,4-diamine
  • MW: 296.327 | Formula: C15H16N6O
  • H donors: 3 H acceptors: 3 LogP: 1.35 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NCc1ccc2c(n1)c(N)nc(n2)N
  • InChi: 1S/C15H16N6O/c1-22-11-4-2-3-9(7-11)18-8-10-5-6-12-13(19-10)14(16)21-15(17)20-12/h2-7,18H,8H2,1H3,(H4,16,17,20,21)
  • InChiKey: VUDSXUWVNZOREL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-[[(3-methoxyphenyl)amino]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
  • (2,4-diaminopyrido[3,2-d]pyrimidin-6-yl)methyl-(3-methoxyphenyl)amine
  • 6-[[(3-methoxyphenyl)amino]methyl]pyrido[2,3-e]pyrimidine-2,4-diamine
  • (2,4-diaminopyrido[6,5-e]pyrimidin-6-yl)methyl-(3-methoxyphenyl)amine
  • AIDS-011491
  • AIDS011491
  • 6-{[(3-Methoxyphenyl)amino]methyl}pyrido[3,2-d]pyrimidine-2,4-diamine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Saccharomyces cerevisiae dihydrofolate reductase Starlite/ChEMBL References
Rattus norvegicus Dihydrofolate reductase Starlite/ChEMBL References
Pneumocystis carinii Dihydrofolate reductase Starlite/ChEMBL References
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium hominis chain A, crystal structure of Dhfr Dihydrofolate reductase   187 aa 182 aa 34.1 %
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 210 aa 30.0 %
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   206 aa 193 aa 29.5 %
Leishmania infantum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 34.3 %
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 210 aa 30.0 %
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 186 aa 37.1 %
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 182 aa 33.5 %
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Dihydrofolate reductase   187 aa 187 aa 35.8 %
Babesia bovis dihydrofolate reductase/thymidilate synthase Dihydrofolate reductase   187 aa 191 aa 31.9 %
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 202 aa 29.2 %
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 33.7 %
Plasmodium yoelii thymidylate synthase, putative Dihydrofolate reductase   187 aa 212 aa 27.8 %
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Leishmania donovani dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 193 aa 32.1 %
Leishmania major dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 211 aa 28.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) sugar transporter 0.0105 0.1232 0.1392
Entamoeba histolytica hypothetical protein 0.0035 0.0317 0.551
Echinococcus granulosus General substrate transporter 0.009 0.1038 0.1038
Schistosoma mansoni hypothetical protein 0.0015 0.0057 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0907 0.0907
Plasmodium falciparum heat shock protein 90, putative 0.017 0.2088 0.361
Echinococcus multilocularis heat shock protein 90 0.0038 0.0359 0.0401
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.1259 0.1439
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0276 0.0404
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.008 0.0907 0.0907
Onchocerca volvulus 0.0628 0.8127 1
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0246 0.0391
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0162 0.0185
Brugia malayi G-protein coupled receptor 0.008 0.0907 0.0999
Onchocerca volvulus 0.008 0.0907 0.1073
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0276 0.0276
Schistosoma mansoni hypothetical protein 0.0035 0.0317 0.0363
Echinococcus granulosus heat shock protein 90 0.0038 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0107 0.1259 0.1423
Loa Loa (eye worm) hypothetical protein 0.0107 0.1259 0.1423
Echinococcus multilocularis orexin receptor type 2 0.008 0.0907 0.1014
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0116 0.0091
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0022 0.0022
Toxoplasma gondii sugar transporter ST3 0.0015 0.0048 0.0022
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.008 0.0907 0.1037
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0107 0.1259 0.1438
Schistosoma mansoni sodium/chloride dependent transporter 0.0628 0.8127 0.9287
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0318 0.0323
Onchocerca volvulus 0.0015 0.0048 0.0011
Echinococcus granulosus thymidylate synthase 0.013 0.1563 0.1563
Brugia malayi beta-lactamase 0.0035 0.0318 0.0323
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0444 0.076
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0162 0.0162
Onchocerca volvulus Putative transporter 0.0015 0.0048 0.0011
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0408 0.3038
Echinococcus multilocularis neuropeptide receptor A26 0.008 0.0907 0.1014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0266 0.0287
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0444 1
Schistosoma mansoni hypothetical protein 0.0282 0.3569 0.4078
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0179 0.0266
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0907 0.1037
Brugia malayi mbt repeat family protein 0.0046 0.0466 0.0492
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0282 0.1973
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0676 0.8752 1
Echinococcus multilocularis solute carrier family 22 0.0015 0.0048 0.0054
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0107 0.1259 0.1407
Schistosoma mansoni intermediate filament proteins 0.0026 0.0201 0.023
Echinococcus multilocularis g-protein coupled receptor 0.008 0.0907 0.1014
Echinococcus granulosus orexin receptor type 2 0.008 0.0907 0.0907
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0036 0.0041
Leishmania major glucose transporter, lmgt3 0.0032 0.0282 0.0457
Schistosoma mansoni sugar transporter 0.0015 0.0048 0.0055
Echinococcus multilocularis neuropeptide receptor 0.008 0.0907 0.1014
Mycobacterium ulcerans hypothetical protein 0.0035 0.0318 0.0362
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0179 0.0266
Mycobacterium leprae Probable lipase LipE 0.0035 0.0318 0.0323
Loa Loa (eye worm) hypothetical protein 0.0023 0.0162 0.0167
Toxoplasma gondii ABC1 family protein 0.0035 0.0318 0.0525
Brugia malayi hypothetical protein 0.0107 0.1259 0.1403
Onchocerca volvulus 0.0026 0.0201 0.02
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0317 0.0363
Trypanosoma brucei C-8 sterol isomerase, putative 0.0356 0.4539 0.8402
Schistosoma mansoni netrin receptor unc5 0.0014 0.004 0.0045
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0058 0.0017
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Schistosoma mansoni hypothetical protein 0.008 0.0907 0.1037
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0346
Echinococcus multilocularis solute carrier family 22 0.0015 0.0048 0.0054
Plasmodium vivax heat shock protein 90, putative 0.003 0.0246 0.035
Echinococcus granulosus sodium and chloride dependent glycine 0.0107 0.1259 0.1259
Schistosoma mansoni growth hormone secretagogue receptor 0.008 0.0907 0.1037
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Onchocerca volvulus 0.0015 0.0048 0.0011
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0444 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0107 0.1259 0.1403
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0051 0.0051
Onchocerca volvulus 0.008 0.0907 0.1073
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.008 0.0907 0.1014
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0276 0.0448
Schistosoma mansoni biogenic amine receptor 0.008 0.0907 0.1037
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0058 0.004
Plasmodium falciparum hexose transporter 0.0105 0.1232 0.2094
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0318 0.0323
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0336 0.0559
Trypanosoma brucei heat shock protein, putative 0.0045 0.0444 0.076
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0058 0.0024
Echinococcus granulosus Ankyrin 0.0014 0.0041 0.0041
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0107 0.1259 0.1259
Schistosoma mansoni hypothetical protein 0.0015 0.0057 0.0065
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0062 0.0667 0.1177
Loa Loa (eye worm) hypothetical protein 0.0033 0.0291 0.0315
Brugia malayi hypothetical protein 0.0062 0.0667 0.0724
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0466 0.0466
Trypanosoma brucei heat shock protein, putative 0.0045 0.0444 0.076
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0005 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0317 0.0355
Schistosoma mansoni glutamate receptor NMDA 0.0011 0.0005 0.0005
Schistosoma mansoni neuropeptide receptor 0.008 0.0907 0.1037
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0318 0.0477
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0444 0.076
Leishmania major heat shock protein, putative 0.003 0.0246 0.0391
Echinococcus multilocularis g protein coupled receptor 0.008 0.0907 0.1014
Onchocerca volvulus 0.0015 0.0048 0.0011
Onchocerca volvulus 0.008 0.0907 0.1073
Echinococcus multilocularis General substrate transporter 0.009 0.1038 0.116
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0493 0.0524
Onchocerca volvulus 0.0046 0.0466 0.0527
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Schistosoma mansoni hypothetical protein 0.008 0.0907 0.1037
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.1563 0.1786
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0802 0.0802
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0907 0.1037
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0036 0.0041
Schistosoma mansoni protein kinase 0.0032 0.0276 0.0316
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Onchocerca volvulus Neuropeptide F receptor homolog 0.008 0.0907 0.1073
Brugia malayi G-protein coupled receptor 0.008 0.0907 0.0999
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus granulosus g protein coupled receptor 0.008 0.0907 0.0907
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.008 0.0907 0.1021
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0221 0.2768 0.315
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0029
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0162 0.0201
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Onchocerca volvulus 0.0015 0.0048 0.0011
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.0907 0.1014
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0298 0.2109
Leishmania major cytochrome p450-like protein 0.0022 0.0149 0.021
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0048 0.0037
Brugia malayi GnHR receptor homolog 0.008 0.0907 0.0999
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0036 0.0036
Echinococcus multilocularis lamin dm0 0.0026 0.0201 0.0225
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0907 0.1037
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0048 0.0055
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0027
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0444 0.076
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0329 0.0336
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0048 0.0022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0057 0.0023
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.004 0.0028
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0282 0.0457
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.0907 0.1037
Onchocerca volvulus 0.0015 0.0048 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0268 0.0289
Loa Loa (eye worm) hypothetical protein 0.0053 0.055 0.0612
Schistosoma mansoni heat shock protein 0.0045 0.0444 0.0507
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0058 0.0065
Brugia malayi Sugar transporter family protein 0.0015 0.0048 0.0013
Trypanosoma brucei glucose transporter 2A 0.0032 0.0282 0.0457
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0907 0.1014
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0268 0.0265
Brugia malayi hypothetical protein 0.0016 0.0064 0.0031
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0162 0.0961
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0058 0.004
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0318 0.2277
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0466 0.052
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0058 0.004
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0276 0.0275
Onchocerca volvulus 0.008 0.0907 0.1073
Schistosoma mansoni opsin-like receptor 0.008 0.0907 0.1037
Echinococcus granulosus lamin dm0 0.0026 0.0201 0.0201
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0907 0.1037
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.008 0.0907 0.1037
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0107 0.1259 0.1403
Schistosoma mansoni protein kinase 0.0032 0.0276 0.0316
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0276 0.0404
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0907 0.0907
Schistosoma mansoni sodium/chloride dependent transporter 0.0107 0.1259 0.1439
Mycobacterium tuberculosis Conserved protein 0.0035 0.0318 0.0323
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0318 0.0525
Onchocerca volvulus 0.008 0.0907 0.1073
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0107 0.1259 0.1439
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.1232 0.223
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0907 0.1014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0058 0.0065
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0346
Treponema pallidum sodium- and chloride- dependent transporter 0.0628 0.8127 1
Echinococcus multilocularis solute carrier family 22 0.0015 0.0048 0.0054
Loa Loa (eye worm) hypothetical protein 0.0046 0.0466 0.0515
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.0907 0.1014
Trypanosoma brucei glucose transporter, putative 0.0032 0.0282 0.0457
Brugia malayi intermediate filament protein 0.0026 0.0201 0.0189
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0179 0.0231
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.004 0.0003
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.1563 0.1752
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0162 0.0181
Schistosoma mansoni peptide (allatostatin)-like receptor 0.008 0.0907 0.1037
Onchocerca volvulus 0.0035 0.0318 0.0344
Brugia malayi hypothetical protein 0.0035 0.0317 0.0322
Echinococcus multilocularis solute carrier family 22 0.0015 0.0048 0.0054
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0109 0.0083
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0276 0.0448
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0268 0.0265
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0317 0.0317
Leishmania major glucose transporter, lmgt1 0.0032 0.0282 0.0457
Plasmodium vivax CDK-related protein kinase 6, putative 0.0444 0.5699 1
Echinococcus multilocularis g protein coupled receptor 0.008 0.0907 0.1014
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0048 0.0054
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0058 0.0058
Echinococcus granulosus solute carrier family 22 0.0015 0.0048 0.0048
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0907 0.0907
Echinococcus granulosus neuropeptides capa receptor 0.008 0.0907 0.0907
Trypanosoma brucei heat shock protein, putative 0.0045 0.0444 0.076
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0318 0.0525
Echinococcus multilocularis serotonin transporter 0.0628 0.8127 0.9084
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0282 0.0457
Brugia malayi G protein-coupled receptor F59B2.13 0.008 0.0907 0.0999
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0336 0.0559
Loa Loa (eye worm) hypothetical protein 0.0182 0.2249 0.2556
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.004 0.0005
Onchocerca volvulus 0.0015 0.0048 0.0011
Brugia malayi Dopamine receptor protein 1 0.0494 0.6363 0.7259
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0036 0.0041
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.1232 0.1377
Brugia malayi Serotonin/octopamine receptor family protein 7 0.008 0.0907 0.0999
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0373 0.0426
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0298 0.2109
Onchocerca volvulus 0.008 0.0907 0.1073
Plasmodium falciparum protein kinase 7 0.0295 0.3745 0.6542
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0057 0.0047
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0282 0.0457
Onchocerca volvulus 0.008 0.0907 0.1073
Echinococcus granulosus heat shock protein 90 0.0045 0.0444 0.0444
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0162 0.0184
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0107 0.1259 0.1403
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0676 0.8752 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.008 0.0907 0.1014
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0318 0.0525
Echinococcus multilocularis fmrfamide receptor 0.008 0.0907 0.1014
Schistosoma mansoni histamine h1 receptor 0.008 0.0907 0.1037
Schistosoma mansoni sodium-dependent amino acid transporter 0.0107 0.1259 0.1439
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0421 0.5395 1
Brugia malayi major facilitator superfamily protein 0.0015 0.0048 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0493 0.0547
Brugia malayi isocitrate dehydrogenase 0.0015 0.0058 0.0024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0907 0.1014
Onchocerca volvulus 0.008 0.0907 0.1073
Schistosoma mansoni hypothetical protein 0.0014 0.004 0.0045
Onchocerca volvulus 0.008 0.0907 0.1073
Echinococcus multilocularis fmrfamide receptor 0.008 0.0907 0.1014
Loa Loa (eye worm) hypothetical protein 0.0202 0.2512 0.2858
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0268 0.0306
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0036 0.0041
Trypanosoma cruzi heat shock protein, putative 0.003 0.0246 0.0391
Brugia malayi hypothetical protein 0.008 0.0907 0.0999
Schistosoma mansoni sugar transporter 0.0015 0.0048 0.0055
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.025 0.028
Onchocerca volvulus 0.0015 0.0048 0.0011
Echinococcus multilocularis serotonin receptor 0.0202 0.2512 0.2808
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0318 0.0346
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0246 0.0275
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0318 0.0323
Trypanosoma brucei glucose transporter, putative 0.0032 0.0282 0.0457
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0907 0.0907
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0149 0.0153
Schistosoma mansoni lamin 0.0026 0.0201 0.023
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0907 0.1014
Trypanosoma brucei glucose transporter, putative 0.0032 0.0282 0.0457
Loa Loa (eye worm) melatonin receptor type 1A 0.008 0.0907 0.1021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0318 0.0363
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0036 0.0041
Echinococcus granulosus death domain containing protein 0.0014 0.004 0.004
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.008 0.0907 0.1014
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0162 0.2874
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0058 0.004
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0058 0.0048
Brugia malayi G protein-coupled receptor 0.008 0.0907 0.0999
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0444 0.076
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.008 0.0907 0.1037
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0493 0.0524
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0318 0.2277
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0107 0.1259 0.1439
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0907 0.1014
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.008 0.0907 0.0999
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus multilocularis neuropeptide receptor 0.008 0.0907 0.1014
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Brugia malayi hypothetical protein 0.008 0.0907 0.0999
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0036 0.0041
Brugia malayi hypothetical protein 0.008 0.0907 0.0999
Schistosoma mansoni amine GPCR 0.008 0.0907 0.1037
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.0907 0.1021
Schistosoma mansoni biogenic amine receptor 0.008 0.0907 0.1037
Trypanosoma brucei glucose transporter 1E 0.0032 0.0282 0.0457
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0036 0.0041
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0041 0.0047
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.1563 0.1752
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0246 0.0255
Onchocerca volvulus 0.0035 0.0318 0.0344
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0356 0.4539 0.8402
Loa Loa (eye worm) solute carrier family 6 member 4 0.0628 0.8127 0.9286
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0907 0.1014
Onchocerca volvulus 0.0015 0.0048 0.0011
Echinococcus granulosus heat shock protein 0.0045 0.0444 0.0444
Echinococcus multilocularis allatostatin A receptor 0.008 0.0907 0.1014
Brugia malayi Serotonin receptor 0.053 0.6836 0.7802
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0276 0.0448
Loa Loa (eye worm) hypothetical protein 0.0032 0.0276 0.0298
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0048 0.0055
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0058 0.004
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0276 0.0276
Brugia malayi Dihydrofolate reductase 0.0676 0.8752 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0466 0.0466
Brugia malayi RE15519p 0.008 0.0907 0.0999
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0048 0.0013
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.208 0.3595
Echinococcus granulosus dro:myosuppressin receptor 0.008 0.0907 0.0907
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Echinococcus granulosus calcium dependent protein kinase 0.003 0.025 0.025
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0036 0.0024
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.0907 0.1014
Onchocerca volvulus 0.0015 0.0048 0.0011
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0058 0.004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2813 0.3186
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0048 0.0037
Echinococcus granulosus g-protein coupled receptor 0.008 0.0907 0.0907
Echinococcus multilocularis alpha 1A adrenergic receptor 0.008 0.0907 0.1014
Schistosoma mansoni cytochrome P450 0.0014 0.0036 0.0042
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0276 0.0404
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0162 0.0234
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0282 0.1973
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0221 0.2768 0.3373
Mycobacterium tuberculosis Conserved protein 0.0035 0.0318 0.0323
Echinococcus granulosus GPCR family 2 0.0015 0.0057 0.0057
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0318 0.0318
Trypanosoma cruzi hexose transporter 0.0032 0.0282 0.0457
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0408 1
Schistosoma mansoni glucose transport protein 0.0105 0.1232 0.1407
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0907 0.1014
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0444 0.076
Schistosoma mansoni amine GPCR 0.008 0.0907 0.1037
Schistosoma mansoni neuropeptide f receptor 76f 0.008 0.0907 0.1037
Loa Loa (eye worm) thymidylate synthase 0.013 0.1563 0.1772
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0057 0.0063
Schistosoma mansoni hypothetical protein 0.0014 0.0036 0.0042
Brugia malayi Protein kinase domain containing protein 0.0016 0.0066 0.0034
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0907 0.0907
Schistosoma mansoni glucose transporter 0.0015 0.0048 0.0055
Loa Loa (eye worm) serotonin transporter b 0.0628 0.8127 0.9286
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.0109 0.0124
Schistosoma mansoni heat shock protein 0.0045 0.0444 0.0507
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0107 0.1259 0.1423
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.208 0.3595
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0036 0.0041
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1232 0.1377
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0276 0.0309
Onchocerca volvulus 0.008 0.0907 0.1073
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0107 0.1259 0.1423
Schistosoma mansoni hypothetical protein 0.008 0.0907 0.1037
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0282 0.0457
Brugia malayi Serotonin receptor 0.008 0.0907 0.0999
Schistosoma mansoni neuropeptide receptor 0.008 0.0907 0.1037
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0276 0.0309
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0051 0.0057
Schistosoma mansoni hypothetical protein 0.0015 0.0057 0.0065
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0149 0.021
Loa Loa (eye worm) sugar transporter 0.0015 0.0048 0.0037
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.208 0.3813
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0421 0.5395 0.9463
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0373 0.0426
Echinococcus multilocularis tachykinin peptides receptor 99D 0.008 0.0907 0.1014
Echinococcus granulosus sodium and chloride dependent glycine 0.0107 0.1259 0.1259
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.008 0.0907 0.1014
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.008 0.0907 0.1021
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.055 0.0615
Entamoeba histolytica hypothetical protein 0.0035 0.0317 0.551
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0336 0.051
Echinococcus granulosus alpha 1A adrenergic receptor 0.008 0.0907 0.0907
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0268 0.0299
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0162 0.0144
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0466 0.0515
Brugia malayi neuropeptide F receptor 0.008 0.0907 0.0999
Echinococcus granulosus lamin 0.0026 0.0201 0.0201
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0276 0.0316
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.055 0.0615
Loa Loa (eye worm) hypothetical protein 0.0107 0.1259 0.1423
Echinococcus granulosus tachykinin peptides receptor 99D 0.008 0.0907 0.0907
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0359 0.0601
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0047
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0444 0.07
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0057 0.0023
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Plasmodium falciparum endoplasmin, putative 0.0032 0.0282 0.0414
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0282 0.1978
Echinococcus granulosus dihydrofolate reductase 0.0676 0.8752 0.8752
Schistosoma mansoni myosin xvIII 0.008 0.0907 0.1037
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus granulosus 7TM GPCR rhodopsin 0.008 0.0907 0.0907
Onchocerca volvulus 0.008 0.0907 0.1073
Echinococcus multilocularis neuropeptide s receptor 0.008 0.0907 0.1014
Loa Loa (eye worm) hypothetical protein 0.0628 0.8127 0.9286
Schistosoma mansoni sugar transporter 0.0015 0.0048 0.0055
Plasmodium falciparum transporter, putative 0.0107 0.1259 0.2143
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.2263 0.2263
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0109 0.0124
Loa Loa (eye worm) TYRA-2 protein 0.008 0.0907 0.1021
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0282 0.1973
Echinococcus granulosus intermediate filament protein 0.0026 0.0201 0.0201
Brugia malayi hypothetical protein 0.0015 0.0048 0.0013
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Onchocerca volvulus 0.0026 0.0201 0.02
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0036 0.0041
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.008 0.0907 0.0999
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0036 0.0041
Trypanosoma brucei glucose transporter, putative 0.0032 0.0282 0.0457
Loa Loa (eye worm) heat shock protein 75 0.003 0.0246 0.0264
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0336 0.0559
Toxoplasma gondii sugar transporter ST2 0.0015 0.0048 0.0022
Echinococcus granulosus g protein coupled receptor 0.008 0.0907 0.0907
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0628 0.8127 0.9287
Schistosoma mansoni glucose transport protein 0.0105 0.1232 0.1407
Echinococcus granulosus g protein coupled receptor 0.008 0.0907 0.0907
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.008 0.0907 0.1021
Chlamydia trachomatis glutamine binding protein 0.0019 0.0109 0.0124
Brugia malayi mbt repeat family protein 0.0046 0.0466 0.0492
Brugia malayi AKH receptor 0.008 0.0907 0.0999
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Brugia malayi hypothetical protein 0.008 0.0907 0.0999
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus granulosus allatostatin A receptor 0.008 0.0907 0.0907
Brugia malayi sulfakinin receptor protein 0.008 0.0907 0.0999
Entamoeba histolytica protein kinase, putative 0.0032 0.0276 0.4053
Leishmania major C-8 sterol isomerase-like protein 0.0356 0.4539 0.8402
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0058 0.0017
Echinococcus granulosus solute carrier family 22 0.0015 0.0048 0.0048
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0318 0.0323
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Brugia malayi Cytochrome P450 family protein 0.0022 0.0149 0.0129
Brugia malayi putative neuropeptide receptor NPR1 0.008 0.0907 0.0999
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1232 0.1377
Loa Loa (eye worm) hypothetical protein 0.0356 0.4539 0.5178
Brugia malayi hypothetical protein 0.0015 0.0048 0.0013
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.0907 0.0907
Brugia malayi hypothetical protein 0.0015 0.0048 0.0013
Schistosoma mansoni opsin-like receptor 0.008 0.0907 0.1037
Echinococcus multilocularis sex peptide receptor 0.008 0.0907 0.1014
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0466 0.052
Loa Loa (eye worm) cytochrome P450 0.0014 0.0036 0.0024
Schistosoma mansoni neuropeptide receptor 0.008 0.0907 0.1037
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.1259 0.1439
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.055 0.055
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0318 0.2277
Trypanosoma brucei heat shock protein, putative 0.0045 0.0444 0.076
Schistosoma mansoni hypothetical protein 0.0105 0.1232 0.1407
Mycobacterium tuberculosis Conserved protein 0.0035 0.0318 0.0323
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0036 0.0041
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0036 0.0041
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.008 0.0907 0.0907
Echinococcus multilocularis sodium and chloride dependent glycine 0.0107 0.1259 0.1407
Echinococcus granulosus vesicular acetylcholine transporter 0.0221 0.2768 0.2768
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0036 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0282 0.1973
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0408 0.0426
Echinococcus multilocularis heat shock protein 90 0.0045 0.0444 0.0496
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0101 0.0121
Echinococcus granulosus netrin receptor unc 5 0.0014 0.004 0.004
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.008 0.0907 0.1014
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.0907 0.1037
Brugia malayi beta-lactamase family protein 0.0035 0.0318 0.0323
Echinococcus multilocularis neuropeptide FF receptor 2 0.008 0.0907 0.1014
Onchocerca volvulus 0.013 0.1563 0.1884
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0149 0.017
Mycobacterium ulcerans beta-lactamase 0.0035 0.0318 0.0362
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0149 0.0153
Trypanosoma brucei heat shock protein, putative 0.0045 0.0444 0.076
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0907 0.1014
Echinococcus granulosus neuropeptide receptor 0.008 0.0907 0.0907
Schistosoma mansoni hypothetical protein 0.0166 0.2034 0.2324
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus granulosus 7tm_1 domain containing protein 0.008 0.0907 0.0907
Loa Loa (eye worm) hypothetical protein 0.0025 0.019 0.02
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0276 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1232 0.1232
Echinococcus multilocularis dihydrofolate reductase 0.0676 0.8752 0.9781
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0466 0.0532
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0019 0.0109 0.0134
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0421 0.5395 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0162 0.0234
Echinococcus granulosus somatostatin receptor 0.008 0.0907 0.0907
Trypanosoma brucei glucose transporter, putative 0.0032 0.0282 0.0457
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1232 0.1232
Leishmania major protein kinase, putative 0.0032 0.0276 0.0447
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0022 0.0025
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0336 0.0559
Brugia malayi Death domain containing protein 0.0014 0.004 0.0003
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0027 0.0208 0.0233
Schistosoma mansoni biogenic amine (5HT) receptor 0.0202 0.2512 0.287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0907 0.1037
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0421 0.5395 1
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.0907 0.1021
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1232 0.1232
Trypanosoma brucei glucose transporter, putative 0.0032 0.0282 0.0457
Brugia malayi hypothetical protein 0.0025 0.0179 0.0163
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.0208 0.0208
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0291 0.0292
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.008 0.0907 0.1037
Trypanosoma brucei glucose transporter, putative 0.0032 0.0282 0.0457
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0276 0.0404
Toxoplasma gondii Hsp90 domain-containing protein 0.017 0.2088 0.3829
Schistosoma mansoni hypothetical protein 0.0051 0.052 0.0594
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0268 0.0268
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0149 0.021
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0246 0.2985
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Brugia malayi Sugar transporter family protein 0.0015 0.0048 0.0013
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0318 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0282 0.1973
Loa Loa (eye worm) hypothetical protein 0.0031 0.0268 0.0289
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0408 0.0693
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0107 0.1259 0.1407
Loa Loa (eye worm) hypothetical protein 0.0628 0.8127 0.9286
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.004 0.0045
Echinococcus granulosus thyrotropin releasing hormone receptor 0.008 0.0907 0.0907
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1232 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.008 0.0907 0.1021
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0036 0.0041
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.0048 0.0493 0.0547
Echinococcus multilocularis GPCR, family 2 0.0015 0.0057 0.0063
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0107 0.1259 0.1439
Loa Loa (eye worm) endoplasmin 0.0045 0.0444 0.049
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0197 0.1259
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.008 0.0907 0.1073
Onchocerca volvulus 0.0107 0.1259 0.1508
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0116 0.0091
Brugia malayi hypothetical protein 0.008 0.0907 0.0999
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0282 0.1973
Echinococcus multilocularis lamin 0.0026 0.0201 0.0225
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0907 0.1014
Schistosoma mansoni sugar transporter 0.0015 0.0048 0.0055
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0318 0.0323
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0162 0.0185
Brugia malayi larval opioid receptor 0.008 0.0907 0.0999
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0201 0.0213
Onchocerca volvulus 0.008 0.0907 0.1073
Onchocerca volvulus 0.0107 0.1259 0.1508
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Echinococcus multilocularis g protein coupled receptor 0.008 0.0907 0.1014
Onchocerca volvulus 0.0015 0.0048 0.0011
Echinococcus multilocularis sodium and chloride dependent glycine 0.0107 0.1259 0.1407
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0444 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0421 0.5395 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.008 0.0907 0.1021
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0088 0.0096
Plasmodium falciparum heat shock protein 90 0.0045 0.0444 0.07
Echinococcus multilocularis endoplasmin 0.0042 0.0408 0.0456
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0048 0.0013
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0058 0.0065
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0057 0.0063
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0318 0.2277
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0466 0.0532
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0048 0.0013
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0107 0.1259 0.2281
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0057 0.0057
Echinococcus multilocularis serotonin receptor 0.0202 0.2512 0.2808
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0336 0.0559
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Schistosoma mansoni hypothetical protein 0.0033 0.0291 0.0333
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0457 0.5867 0.6557
Echinococcus granulosus neuropeptide receptor A26 0.008 0.0907 0.0907
Echinococcus granulosus solute carrier family 22 0.0015 0.0048 0.0048
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0676 0.8752 1
Entamoeba histolytica hypothetical protein 0.0035 0.0317 0.551
Brugia malayi hypothetical protein 0.008 0.0907 0.0999
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0907 0.0907
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0179 0.0231
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0408 0.0465
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.008 0.0907 0.1037
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0107 0.1259 0.1259
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0329 0.0329
Onchocerca volvulus 0.0035 0.0318 0.0344
Brugia malayi neuropeptide F receptor 0.008 0.0907 0.0999
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Brugia malayi Dopamine receptor 0.008 0.0907 0.0999
Echinococcus granulosus neuropeptide Y receptor 0.008 0.0907 0.0907
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0036 0.0041
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0276 0.0276
Onchocerca volvulus 0.0015 0.0048 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.0907 0.1021
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.0208 0.0233
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.004 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0907 0.0907
Toxoplasma gondii hypothetical protein 0.0107 0.1259 0.2281
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.004 0.0044
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.008 0.0907 0.1014
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.008 0.0907 0.1014
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.055 0.0629
Loa Loa (eye worm) hypothetical protein 0.0026 0.0201 0.0213
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0276 0.0404
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0276 0.0298
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0205
Loa Loa (eye worm) beta-lactamase 0.0035 0.0318 0.0346
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0268 0.0265
Echinococcus multilocularis Ankyrin 0.0014 0.0041 0.0046
Schistosoma mansoni adenoreceptor 0.008 0.0907 0.1037
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0444 0.076
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus multilocularis conserved hypothetical protein 0.069 0.8947 1
Echinococcus multilocularis thymidylate synthase 0.013 0.1563 0.1747
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0019 0.0109 0.0134
Trichomonas vaginalis esterase, putative 0.0035 0.0318 0.2277
Brugia malayi Hsp90 protein 0.003 0.0246 0.0241
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0197 0.0264
Schistosoma mansoni biogenic amine receptor 0.008 0.0907 0.1037
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1232 0.1377
Echinococcus multilocularis dro:myosuppressin receptor 0.008 0.0907 0.1014
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0036 0.0041
Echinococcus granulosus fmrfamide receptor 0.008 0.0907 0.0907
Echinococcus granulosus peptide allatostatin:somatostatin 0.008 0.0907 0.0907
Schistosoma mansoni amine GPCR 0.008 0.0907 0.1037
Mycobacterium ulcerans lipase LipD 0.0035 0.0318 0.0362
Schistosoma mansoni amine GPCR 0.008 0.0907 0.1037
Brugia malayi thymidylate synthase 0.013 0.1563 0.1752
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0318 0.0362
Toxoplasma gondii sugar transporter ST1 0.0015 0.0048 0.0022
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0282 0.0457
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0907 0.1014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0907 0.1037
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.004 0.0027
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0282 0.1973
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0907 0.1037
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0116 0.0091
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0048 0.0013
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0276 0.0447
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Echinococcus granulosus neuropeptide receptor 0.008 0.0907 0.0907
Onchocerca volvulus 0.0015 0.0048 0.0011
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0005 0.0005
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0048 0.0013
Loa Loa (eye worm) hypothetical protein 0.0025 0.0179 0.0187
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0276 0.0404
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0179 0.0266
Onchocerca volvulus 0.0107 0.1259 0.1508
Trypanosoma brucei heat shock protein, putative 0.0045 0.0444 0.076
Loa Loa (eye worm) hypothetical protein 0.0628 0.8127 0.9286
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0276 0.0276
Leishmania major hypothetical protein, conserved 0.0015 0.0048 0.0022
Brugia malayi Dopamine receptor protein 2 0.008 0.0907 0.0999
Giardia lamblia Grp94/Hsp90 0.0042 0.0408 0.9085
Schistosoma mansoni opsin-like receptor 0.008 0.0907 0.1037
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0444 0.076
Brugia malayi putative neuropeptide receptor 0.008 0.0907 0.0999
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0329 0.0368
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Loa Loa (eye worm) MBCTL1 0.0053 0.055 0.0612
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.055 0.0589
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0179 0.0231
Echinococcus multilocularis vesicular acetylcholine transporter 0.0221 0.2768 0.3093
Entamoeba histolytica hypothetical protein 0.0035 0.0317 0.551
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0024 0.001
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0421 0.5395 0.9463
Chlamydia trachomatis dihydrofolate reductase 0.0676 0.8752 1
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0336 0.051
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0907 0.0907
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Brugia malayi dihydrofolate reductase family protein 0.0676 0.8752 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0346
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0359 0.7849
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0346
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0007
Echinococcus multilocularis somatostatin receptor 0.008 0.0907 0.1014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0907 0.1037
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus granulosus biogenic amine 5HT receptor 0.0457 0.5867 0.5867
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0048 0.0048
Schistosoma mansoni dihydrofolate reductase 0.0676 0.8752 1
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0907 0.0907
Trypanosoma brucei heat shock protein, putative 0.0045 0.0444 0.076
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.055 0.055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0907 0.1037
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0246 0.0391
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0048 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0907 0.1037
Schistosoma mansoni hypothetical protein 0.008 0.0907 0.1037
Loa Loa (eye worm) dihydrofolate reductase 0.0676 0.8752 1
Echinococcus multilocularis heat shock protein 0.0045 0.0444 0.0496
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.1259 0.1439
Echinococcus granulosus neuropeptide Y receptor 0.008 0.0907 0.0907
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Onchocerca volvulus 0.008 0.0907 0.1073
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.0907 0.1021
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0124 0.0641
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.004 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0318 0.0363
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0408 0.3038
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0048 0.0055
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1232 0.1232
Schistosoma mansoni hypothetical protein 0.0015 0.0057 0.0065
Brugia malayi gonadotropin-releasing hormone receptor 2 0.008 0.0907 0.0999
Brugia malayi beta-lactamase family protein 0.0035 0.0318 0.0323
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Loa Loa (eye worm) hypothetical protein 0.0107 0.1259 0.1423
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0336 0.0559
Echinococcus multilocularis geminin 0.0166 0.2034 0.2273
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0359 0.2625
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0276 0.0404
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0466 0.0527
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0318 0.0362
Brugia malayi heat shock protein 90 0.0045 0.0444 0.0468
Mycobacterium tuberculosis Hypothetical protein 0.0062 0.0667 0.0724
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0444 0.049
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0107 0.1259 0.1259
Echinococcus granulosus solute carrier family 22 0.0015 0.0048 0.0048
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0408 0.0426
Schistosoma mansoni lamin 0.0026 0.0201 0.023
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0276 0.1927
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0466 0.0532
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0268 0.5547
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0058 0.004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0907 0.1037
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.0907 0.1037
Brugia malayi Uncoordinated protein 44 0.0014 0.004 0.0003
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0276 0.0309
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0048 0.0022
Onchocerca volvulus 0.008 0.0907 0.1073
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.008 0.0907 0.0907
Echinococcus multilocularis 0.0014 0.0036 0.0041
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0268 0.375
Echinococcus granulosus neuropeptide FF receptor 2 0.008 0.0907 0.0907
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0282 0.0457
Loa Loa (eye worm) hypothetical protein 0.0107 0.1259 0.1423
Loa Loa (eye worm) hypothetical protein 0.0107 0.1259 0.1423
Trypanosoma brucei glucose transporter, putative 0.0032 0.0282 0.0457
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.0907 0.1037
Echinococcus granulosus neuropeptides capa receptor 0.008 0.0907 0.0907
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0444 0.076
Toxoplasma gondii hypothetical protein 0.0107 0.1259 0.2281
Brugia malayi Cam kinase protein 1 0.0032 0.0276 0.0275
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0201 0.0213
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.2263 0.2529
Schistosoma mansoni amine GPCR 0.008 0.0907 0.1037
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0346
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0346
Schistosoma mansoni hypothetical protein 0.0166 0.2034 0.2324
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0162 0.0201
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0318 0.2277
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.0907 0.1014
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0005 0.0005
Schistosoma mansoni endoplasmin 0.0045 0.0444 0.0507
Leishmania major hypothetical protein, conserved 0.0035 0.0318 0.0525
Schistosoma mansoni glucose transport protein 0.0105 0.1232 0.1407
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus granulosus G protein coupled receptor 139 0.008 0.0907 0.0907
Brugia malayi Tachykinin-like peptides receptor 99D 0.008 0.0907 0.0999
Echinococcus granulosus geminin 0.0166 0.2034 0.2034
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0107 0.1259 0.1439
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Leishmania major glucose transporter, lmgt2 0.0032 0.0282 0.0457
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0011 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0036 0.0041
Onchocerca volvulus 0.0015 0.0048 0.0011
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0058 0.0066
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0107 0.1259 0.1439
Echinococcus multilocularis G protein coupled receptor 139 0.008 0.0907 0.1014
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0107 0.1259 0.2281
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.008 0.0907 0.1037
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0276 0.0309
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0051 0.0058
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0359 0.0359
Toxoplasma gondii protein kinase, putative 0.0295 0.3745 0.6921
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0268 0.0306
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0276 0.0404
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0058 0.0065
Onchocerca volvulus 0.008 0.0907 0.1073
Schistosoma mansoni sodium/chloride dependent transporter 0.0109 0.1285 0.1469
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0149 0.0153
Brugia malayi Cytochrome P450 family protein 0.0022 0.0149 0.0129
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0268 0.1855
Entamoeba histolytica protein kinase, putative 0.0032 0.0276 0.4053
Brugia malayi follicle stimulating hormone receptor 0.008 0.0907 0.0999
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0107 0.1259 0.1407
Onchocerca volvulus 0.0015 0.0048 0.0011
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0048 0.0022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.0907 0.1014
Schistosoma mansoni neuropeptide receptor 0.008 0.0907 0.1037
Schistosoma mansoni biogenic amine (5HT) receptor 0.0457 0.5867 0.6704
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0107 0.1259 0.1259
Leishmania major hypothetical protein, conserved 0.0025 0.0179 0.0266
Schistosoma mansoni endoplasmin 0.0045 0.0444 0.0507
Plasmodium vivax heat shock protein, putative 0.017 0.2088 0.361
Loa Loa (eye worm) hypothetical protein 0.0015 0.0051 0.004
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0359 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0667 0.5233
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.0907 0.1014
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Brugia malayi hypothetical protein 0.008 0.0907 0.0999
Plasmodium vivax hypothetical protein, conserved 0.0107 0.1259 0.2143
Schistosoma mansoni vesicular acetylcholine transporter 0.0221 0.2768 0.3162
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0048 0.0022
Plasmodium falciparum protein kinase 6 0.0444 0.5699 1
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0162 0.0234
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0318 0.0323
Brugia malayi major facilitator superfamily protein 0.0015 0.0048 0.0013
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0444 0.076
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0005 0.0005
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0179 0.0266
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0318 0.0355
Loa Loa (eye worm) hypothetical protein 0.0494 0.6363 0.7266
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0162 0.0184
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0058 0.0065
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0058 0.0024
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0162 0.0234
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0282 0.0457
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0356 0.4539 0.5166
Echinococcus granulosus serotonin transporter 0.0628 0.8127 0.8127
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0802 0.0896
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0149 0.021
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0107 0.1259 0.1403
Onchocerca volvulus 0.0015 0.0048 0.0011
Echinococcus granulosus endoplasmin 0.0042 0.0408 0.0408
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.008 0.0907 0.1037
Trypanosoma brucei heat shock protein, putative 0.0045 0.0444 0.076
Treponema pallidum heat shock protein 90 0.0042 0.0408 0.0501
Plasmodium vivax amine transporter, putative 0.0107 0.1259 0.2143
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0005 0.0005
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0282 0.1978
Onchocerca volvulus 0.0015 0.0048 0.0011
Echinococcus granulosus sex peptide receptor 0.008 0.0907 0.0907
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0318 0.0323
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0048 0.0022
Brugia malayi Melatonin receptor type 1A 0.008 0.0907 0.0999
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0907 0.1037
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Mycobacterium ulcerans thymidylate synthase 0.013 0.1563 0.1786
Onchocerca volvulus 0.008 0.0907 0.1073
Leishmania major heat shock protein 83-1 0.0045 0.0444 0.076
Echinococcus granulosus neuropeptide s receptor 0.008 0.0907 0.0907
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0162 0.0184
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Onchocerca volvulus 0.008 0.0907 0.1073
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0276 0.0298
Echinococcus multilocularis musashi 0.0026 0.0201 0.0225
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0037
Loa Loa (eye worm) norepinephrine transporter 0.0628 0.8127 0.9286
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0628 0.8127 0.9284
Brugia malayi Sugar transporter family protein 0.0105 0.1232 0.1371
Brugia malayi Endoplasmin precursor 0.0045 0.0444 0.0468
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0107 0.1259 0.2281
Echinococcus granulosus serotonin receptor 0.008 0.0907 0.0907
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0162 0.0144
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.0907 0.0907
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Plasmodium vivax hexose transporter 0.0105 0.1232 0.2094
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0444 0.3344
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0329 0.0359
Loa Loa (eye worm) hypothetical protein 0.0202 0.2512 0.2858
Brugia malayi hypothetical protein 0.008 0.0907 0.0999
Schistosoma mansoni alpha-1 adrenergic receptor 0.008 0.0907 0.1037
Schistosoma mansoni heat shock protein 0.003 0.0246 0.0281
Mycobacterium ulcerans sugar transporter 0.0015 0.0048 0.0055
Echinococcus granulosus biogenic amine 5HT receptor 0.0202 0.2512 0.2512
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0907 0.0907
Plasmodium vivax endoplasmin, putative 0.0045 0.0444 0.07
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0201 0.0189
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0444 0.076
Plasmodium falciparum amino acid transporter, putative 0.0107 0.1259 0.2143
Schistosoma mansoni protein kinase 0.0032 0.0276 0.0316
Trypanosoma brucei sugar transporter, putative 0.0015 0.0048 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0907 0.1014
Loa Loa (eye worm) hypothetical protein 0.0107 0.1259 0.1423
Loa Loa (eye worm) hypothetical protein 0.008 0.0907 0.1021
Brugia malayi vesicular acetylcholine transporter unc-17 0.0221 0.2768 0.3134
Echinococcus granulosus glutamate receptor 2 0.0011 0.0005 0.0005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0318 0.0323
Brugia malayi ORL1-like opioid receptor 0.008 0.0907 0.0999
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.008 0.0907 0.0999
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0011 0.0005 0.0005
Brugia malayi hypothetical protein 0.008 0.0907 0.0999
Brugia malayi hypothetical protein 0.008 0.0907 0.0999

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.77 Inhibition of Pneumocystis carinii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 6.699 Inhibition of rat liver dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 7 Inhibition of Toxoplasma gondii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.1 uM Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. ChEMBL. 8627607
IC50 (binding) = 0.1 uM Inhibition of Toxoplasma gondii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.1 uM Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. ChEMBL. 8627607
IC50 (binding) = 0.1 uM Inhibition of Toxoplasma gondii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.2 uM Inhibitory activity against rat liver dihydrofolate reductase. ChEMBL. 8627607
IC50 (binding) = 0.2 uM Inhibition of rat liver dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.2 uM Inhibitory activity against rat liver dihydrofolate reductase. ChEMBL. 8627607
IC50 (binding) = 0.2 uM Inhibition of rat liver dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 1.7 uM Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. ChEMBL. 8627607
IC50 (binding) = 1.7 uM Inhibition of Pneumocystis carinii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 1.7 uM Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. ChEMBL. 8627607
IC50 (binding) = 1.7 uM Inhibition of Pneumocystis carinii dihydrofolate reductase ChEMBL. 15743188
Log IC50 (binding) = 5.7696 Inhibition of Pneumocystis carinii dihydrofolate reductase ChEMBL. 15743188
Log IC50 (binding) = 6.699 Inhibition of rat liver dihydrofolate reductase ChEMBL. 15743188
Log IC50 (binding) = 7 Inhibition of Toxoplasma gondii dihydrofolate reductase ChEMBL. 15743188
Selectivity (binding) = 0.12 Ratio of inhibitory concentration of rat liver and Pneumocystis carinii DHFR. ChEMBL. 8627607
Selectivity (binding) = 2 Ratio of inhibitory concentration of rat liver and Toxoplasma gondii DHFR ChEMBL. 8627607

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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