Detailed information for compound 79380

Basic information

Technical information
  • TDR Targets ID: 79380
  • Name: 5-(2-ethoxyphenyl)-1,3-dimethyl-4H-pyrazolo[4 ,3-d]pyrimidin-7-one
  • MW: 284.313 | Formula: C15H16N4O2
  • H donors: 1 H acceptors: 2 LogP: 1.73 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1c1nc2c(C)nn(c2c(=O)[nH]1)C
  • InChi: 1S/C15H16N4O2/c1-4-21-11-8-6-5-7-10(11)14-16-12-9(2)18-19(3)13(12)15(20)17-14/h5-8H,4H2,1-3H3,(H,16,17,20)
  • InChiKey: SRVVOQVTSUQJCP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-dimethyl-5-o-phenetyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
  • 5-(2-ethoxyphenyl)-1,3-dimethyl-4H-pyrazolo[5,4-e]pyrimidin-7-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens phosphodiesterase 5A, cGMP-specific Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) PDE1B protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium parvum cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania donovani phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania mexicana phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense 3, 5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense 3', 5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania infantum cAMP phosphodiesterase A Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Cryptosporidium hominis cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Phosphodiesterase 1   535 aa 463 aa 28.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Brugia malayi intermediate filament protein 0.0026 0.0123 0.0278
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Echinococcus multilocularis RUN 0.0061 0.0384 0.0384
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0034 0.018 0.1027
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0036 0.0618
Brugia malayi nuclear receptor RXR 0.0065 0.0414 0.099
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Trichomonas vaginalis esterase, putative 0.0035 0.0188 0.1096
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0369 0.082
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0022 0.0022
Loa Loa (eye worm) nuclear receptor NHR-67 0.0065 0.0414 0.101
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0036 0.0618
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0064 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0049 0.0049
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0073 0.0473 0.1152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0245
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.087
Mycobacterium ulcerans lipase LipD 0.0035 0.0188 0.4943
Schistosoma mansoni cpg binding protein 0.0029 0.0146 0.0137
Loa Loa (eye worm) hypothetical protein 0.0035 0.0188 0.046
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0018 0.0063 0.0063
Leishmania major cathepsin L-like protease 0.0016 0.0049 0.0033
Schistosoma mansoni lipoxygenase 0.0061 0.0384 0.0376
Echinococcus multilocularis thyroid hormone receptor alpha 0.026 0.1863 0.1863
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0036 0.0618
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.018 0.0355
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0139 0.0959 0.0959
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0312 0.076
Echinococcus granulosus ubiquitin specific protease 41 0.0072 0.0461 0.0461
Brugia malayi hypothetical protein 0.0035 0.0188 0.0437
Schistosoma mansoni heat shock protein 0.0034 0.018 0.0171
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0036 0.0618
Brugia malayi Carboxylesterase family protein 0.008 0.052 0.1248
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0018 0.0063 0.0063
Brugia malayi hypothetical protein 0.0065 0.0414 0.099
Brugia malayi Cathepsin L-like precursor 0.0016 0.0049 0.0098
Brugia malayi kinase, mitochondrial precursor 0.0561 0.4102 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.03
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Brugia malayi Endoplasmin precursor 0.0034 0.018 0.0417
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0094 0.0629 0.0629
Loa Loa (eye worm) hypothetical protein 0.0026 0.012 0.0292
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0063 0.0067
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0461 0.1047
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0065 0.0414 0.101
Loa Loa (eye worm) hypothetical protein 0.0016 0.0049 0.012
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0018 0.0063 0.0328
Loa Loa (eye worm) beta-lactamase 0.0035 0.0188 0.046
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0049 0.0049
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Echinococcus granulosus ecdysone induced protein 78C 0.0139 0.0959 0.0959
Brugia malayi follicle stimulating hormone receptor 0.0225 0.1603 0.3893
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0042 0.0238 0.0238
Loa Loa (eye worm) carboxylesterase 0.0013 0.0028 0.0069
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1437 0.3504
Brugia malayi N-terminal motif family protein 0.0175 0.1233 0.2991
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0188 0.0188
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0034 0.018 0.9442
Echinococcus granulosus heat shock protein 0.0034 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.008 0.052 0.1268
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Brugia malayi heat shock protein 90 0.0034 0.018 0.0417
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0013 0.0028 0.0091
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0188 0.1096
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0057 0.0355 0.216
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0057 0.0355 0.216
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0389 0.087
Echinococcus granulosus Polycystic kidney disease protein 0.0061 0.0384 0.0384
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.018 0.2756
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0073 0.0473 0.0464
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0188 0.0376
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0052 0.0314 0.1901
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0139 0.0959 0.2337
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0036 0.0618
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0034 0.018 0.1053
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0461 0.0461
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0034 0.018 0.1053
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0083 0.0544 0.1249
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0013 0.0028 0.0019
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0373 0.0373
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0018 0.0063 0.0131
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0349 0.0771
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0088 0.0581 0.1342
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0049 0.012
Echinococcus granulosus thyroid hormone receptor alpha 0.0065 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.007
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0036 0.0618
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0018 0.0063 0.0328
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0579 0.3496
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0088 0.0579 0.0579
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0072 0.0461 0.1104
Plasmodium vivax SET domain protein, putative 0.003 0.0149 0.219
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0013 0.0028 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0139 0.0959 0.2337
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0065 0.0414 0.0414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0139 0.0959 0.2337
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0195 0.138 0.3306
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Plasmodium vivax multidomain scavenger receptor, putative 0.0061 0.0384 0.6027
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0018 0.0063 0.0328
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0034 0.018 0.4702
Echinococcus granulosus intermediate filament protein 0.0026 0.0123 0.0123
Chlamydia trachomatis DNA gyrase subunit B 0.0065 0.0414 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0018 0.0063 0.0063
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0561 0.4102 0.4102
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0042 0.0238 0.1396
Leishmania major hypothetical protein, conserved 0.0018 0.0063 0.0067
Schistosoma mansoni cytochrome P450 0.0014 0.0036 0.0026
Brugia malayi cytochrome P450 0.0014 0.0036 0.0065
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0083 0.0544 0.3267
Echinococcus multilocularis FTZ F1 alpha 0.0139 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0069
Toxoplasma gondii exonuclease III APE 0.0018 0.0064 0.0311
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0034 0.018 0.4702
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0188 0.1096
Giardia lamblia DNA topoisomerase II 0.006 0.0377 0.7884
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0013 0.0028 0.0116
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0149 0.0832
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0083 0.0544 0.3267
Brugia malayi hypothetical protein 0.0065 0.0414 0.099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0245
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0367 0.0367
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0103 0.4393
Trypanosoma brucei heat shock protein, putative 0.0034 0.018 0.0355
Echinococcus granulosus cathepsin l1 0.0011 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0049 0.0245
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0064 0.0336
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0099 0.024
Brugia malayi Cathepsin L-like precursor 0.0016 0.0049 0.0098
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0139 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0069
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0188 0.1107
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0018 0.0063 0.0328
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0081 0.0528 0.1212
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0083 0.0544 0.1249
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0188 0.284
Plasmodium falciparum heat shock protein 90 0.0034 0.018 0.2702
Schistosoma mansoni zinc finger protein 0.0065 0.0414 0.0405
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0579
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0461 0.2763
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0188 0.0376
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.0369 0.2199
Toxoplasma gondii hypothetical protein 0.0023 0.0103 0.055
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0064 0.0818
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0083 0.0544 0.3267
Brugia malayi Carboxylesterase family protein 0.0013 0.0028 0.0046
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0081 0.0528 0.1212
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0049 0.0049
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0389 0.087
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.0036 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0063 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0409 0.2443
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0036 0.0618
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Leishmania major mitochondrial DNA topoisomerase II 0.0081 0.0528 0.1212
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0561 0.4102 0.4102
Brugia malayi Cathepsin L-like precursor 0.0016 0.0049 0.0098
Plasmodium vivax vivapain-2 0.0016 0.0049 0.0576
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0083 0.0544 0.3267
Brugia malayi Cytochrome P450 family protein 0.0052 0.0312 0.0739
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0018 0.0063 0.0063
Schistosoma mansoni BC026374 protein (S09 family) 0.0013 0.0028 0.0019
Echinococcus granulosus acetylcholinesterase 0.008 0.052 0.052
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0018 0.0063 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0389 0.087
Schistosoma mansoni steroid hormone receptor ad4bp 0.0139 0.0959 0.095
Schistosoma mansoni polycystin 1-related 0.0061 0.0384 0.0376
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1645 1
Brugia malayi Carboxylesterase family protein 0.008 0.052 0.1248
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Trypanosoma brucei heat shock protein, putative 0.0034 0.018 0.0355
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0139 0.0959 0.095
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0188 0.1107
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0034 0.018 0.4702
Loa Loa (eye worm) hypothetical protein 0.003 0.0149 0.0362
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0013 0.0028 0.0019
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Echinococcus multilocularis geminin 0.0178 0.125 0.125
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0261 0.1537
Brugia malayi nuclear hormone receptor family member nhr-6 0.0065 0.0414 0.099
Toxoplasma gondii heat shock protein HSP90 0.0034 0.018 0.1027
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0088 0.0579 0.0579
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0233 0.3611
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.0036 0.0138
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.0036 0.0138
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0065 0.0414 0.0414
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0064 0.0319
Brugia malayi nuclear receptor RXR 0.0073 0.0473 0.1132
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0018 0.0063 0.0131
Brugia malayi Cathepsin L-like precursor 0.0016 0.0049 0.0098
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0018 0.0063 0.0063
Schistosoma mansoni RAR-like nuclear receptor 0.0139 0.0959 0.095
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0188 0.046
Onchocerca volvulus 0.0013 0.0028 0.0088
Loa Loa (eye worm) heat shock protein 90 0.0034 0.018 0.0439
Plasmodium vivax heat shock protein 86, putative 0.0034 0.018 0.2702
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0153
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1591 1
Brugia malayi Nuclear hormone receptor-like 1 0.0139 0.0959 0.232
Leishmania major cathepsin L-like protease 0.0016 0.0049 0.0033
Mycobacterium tuberculosis Carboxylesterase LipT 0.0013 0.0028 0.0091
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0036 0.0618
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0083 0.0544 0.3267
Schistosoma mansoni hypothetical protein 0.0395 0.2867 0.2861
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.018 0.2756
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.0036 0.0138
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0188 0.0376
Echinococcus granulosus heat shock protein 90 0.0034 0.018 0.018
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0049 0.004
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.1059 0.105
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0034 0.018 0.1053
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0077 0.05 0.2276
Schistosoma mansoni ap endonuclease 0.0018 0.0064 0.0055
Brugia malayi Cytochrome P450 family protein 0.0023 0.0099 0.0218
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0088 0.0579 0.1337
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0069
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0373 0.7779
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0049 0.0576
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0461 0.2763
Loa Loa (eye worm) acetyltransferase 0.0152 0.1059 0.2581
Loa Loa (eye worm) hypothetical protein 0.0561 0.4102 1
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2867 0.2867
Entamoeba histolytica cysteine protease, putative 0.0016 0.0049 0.0646
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0188 0.4943
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0018 0.0063 0.0328
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0172 0.1206 0.1206
Leishmania major hypothetical protein, conserved 0.0018 0.0063 0.0067
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0461 0.1047
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0261 0.0261
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0018 0.0063 0.0067
Trypanosoma brucei DNA topoisomerase ii 0.0081 0.0528 0.1212
Onchocerca volvulus Protein ultraspiracle homolog 0.0139 0.0959 0.4406
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0367 0.0367
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0034 0.018 0.554
Entamoeba histolytica hypothetical protein 0.0035 0.0188 0.289
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0036 0.0618
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0239 0.1706 0.1706
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0034 0.018 0.2702
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0139 0.0959 0.0959
Schistosoma mansoni nuclear receptor 0.0065 0.0414 0.0405
Entamoeba histolytica hypothetical protein 0.0035 0.0188 0.289
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0036 0.0618
Onchocerca volvulus 0.0065 0.0414 0.188
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Onchocerca volvulus 0.0139 0.0959 0.4406
Loa Loa (eye worm) fibroinase 0.0016 0.0049 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0063 0.0067
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0049 0.0186
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0099 0.024
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0561 0.4102 0.4102
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0373 0.0373
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0064 0.0156
Echinococcus multilocularis cpg binding protein 0.0029 0.0146 0.0146
Onchocerca volvulus 0.0016 0.0049 0.0186
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0188 0.1096
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0291 0.0627
Echinococcus granulosus neuroligin 0.0013 0.0028 0.0028
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.018 0.0355
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0018 0.0063 0.0054
Chlamydia trachomatis DNA gyrase subunit B 0.0052 0.0314 0.7493
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0064 0.1424
Trichomonas vaginalis receptor histidine kinase, putative 0.0034 0.018 0.1044
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.0384 0.0384
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0461 0.1047
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0018 0.0063 0.0328
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0373 0.0829
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.087
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.1233 0.5681
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.018 0.0355
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0072 0.0461 0.0452
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0034 0.018 0.4702
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0261 0.4014
Onchocerca volvulus 0.0013 0.0028 0.0088
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0139 0.0959 0.0959
Mycobacterium ulcerans beta-lactamase 0.0035 0.0188 0.4943
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0042 0.0238 0.0558
Schistosoma mansoni nuclear receptor 0.0065 0.0414 0.0405
Leishmania major cathepsin L-like protease 0.0016 0.0049 0.0033
Mycobacterium tuberculosis Possible two component sensor kinase 0.0034 0.018 0.1053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0188 0.046
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0036 0.0036
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0049 0.0646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Toxoplasma gondii cathepsin CPL 0.0016 0.0049 0.0219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0367 1
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0063 0.0067
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0139 0.0959 0.0959
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0018 0.0063 0.0054
Mycobacterium tuberculosis Conserved protein 0.0035 0.0188 0.1107
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0099 0.24
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0188 0.1096
Loa Loa (eye worm) hypothetical protein 0.0073 0.0473 0.1152
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0367 0.2184
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0077 0.05 0.2276
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0123 0.03
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0461 0.2763
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0064 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0245
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0083 0.0544 0.3267
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0034 0.018 0.1044
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0034 0.018 0.9442
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0373 0.0829
Plasmodium falciparum DNA topoisomerase 2 0.0094 0.0629 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0064 0.0818
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0034 0.018 0.1053
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0239 0.1706 0.4147
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Loa Loa (eye worm) hypothetical protein 0.0073 0.0473 0.1152
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Echinococcus granulosus carboxylesterase 5A 0.008 0.052 0.052
Schistosoma mansoni neuroligin 3 (S09 family) 0.0013 0.0028 0.0019
Echinococcus granulosus BC026374 protein S09 family 0.0013 0.0028 0.0028
Leishmania major developmentally regulated phosphoprotein-like protein 0.0561 0.4102 1
Brugia malayi Carboxylesterase family protein 0.0013 0.0028 0.0046
Schistosoma mansoni cpg binding protein 0.0028 0.0135 0.0125
Brugia malayi Doublecortin family protein 0.0061 0.0384 0.0917
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.0036 0.0138
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0036 0.0618
Brugia malayi MAP kinase sur-1 0.006 0.0373 0.0888
Brugia malayi Nuclear hormone receptor E75 0.0065 0.0414 0.099
Loa Loa (eye worm) hypothetical protein 0.0139 0.0959 0.2337
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0033 0.0057
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.008 0.052 0.0511
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0139 0.0959 0.0959
Brugia malayi beta-lactamase family protein 0.0035 0.0188 0.0438
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.0384 0.0384
Brugia malayi tailless protein 0.0065 0.0414 0.099
Onchocerca volvulus 0.0013 0.0028 0.0088
Onchocerca volvulus 0.0016 0.0049 0.0186
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0373 0.0829
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0072 0.0461 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0083 0.0544 0.0544
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0094 0.0629 0.1514
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0245
Mycobacterium ulcerans putative regultory protein 0.0034 0.018 0.4702
Schistosoma mansoni endoplasmin 0.0034 0.018 0.0171
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0034 0.018 0.0355
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0153
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0033 0.008
Leishmania major cytochrome p450-like protein 0.0023 0.0099 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.0036 0.0138
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0018 0.0063 0.0054
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0065 0.0414 0.0414
Echinococcus multilocularis lamin dm0 0.0026 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.087
Trypanosoma cruzi DNA topoisomerase II, putative 0.0088 0.0581 0.1342
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0149 0.0149
Trypanosoma brucei heat shock protein, putative 0.0034 0.018 0.0355
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0036 0.0618
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0018 0.0063 0.0799
Echinococcus granulosus Nuclear hormone receptor HR96 0.0065 0.0414 0.0414
Schistosoma mansoni coup transcription factor 0.0139 0.0959 0.095
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0036 0.0618
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0261 0.1525
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0083 0.0544 0.0535
Trypanosoma brucei developmentally regulated phosphoprotein 0.0561 0.4102 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0561 0.4102 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Plasmodium vivax endoplasmin, putative 0.0034 0.018 0.2702
Schistosoma mansoni DNA topoisomerase II 0.0094 0.0629 0.062
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.007
Trypanosoma brucei heat shock protein, putative 0.0034 0.018 0.0355
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0103 0.1447
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0139 0.0959 0.0959
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0188 0.1107
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0373 0.0909
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.007
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0049 0.0049
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0139 0.0959 0.0959
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0065 0.0414 0.188
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0049 0.004
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0057 0.0355 0.9643
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0139 0.0959 0.232
Loa Loa (eye worm) hypothetical protein 0.0073 0.0473 0.1152
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0195 0.138 0.3306
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0261 0.1537
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Schistosoma mansoni endoplasmin 0.0034 0.018 0.0171
Leishmania major cathepsin L-like protease 0.0016 0.0049 0.0033
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0064 0.1678
Loa Loa (eye worm) hypothetical protein 0.0139 0.0959 0.2337
Schistosoma mansoni acetylcholinesterase 0.0013 0.0028 0.0019
Toxoplasma gondii DNA topoisomerase 2, putative 0.0094 0.0629 0.38
Toxoplasma gondii hypothetical protein 0.0065 0.0409 0.2442
Brugia malayi ecdysone receptor 0.0065 0.0414 0.099
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0172 0.1206 0.1206
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0149 0.0149
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Loa Loa (eye worm) steroid hormone receptor 0.0139 0.0959 0.2337
Brugia malayi photoreceptor-specific nuclear receptor 0.0139 0.0959 0.232
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0018 0.0063 0.0799
Onchocerca volvulus 0.0061 0.0384 0.1741
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0018 0.0063 0.0131
Brugia malayi Cytochrome P450 family protein 0.0023 0.0099 0.0218
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Brugia malayi Pre-SET motif family protein 0.003 0.0149 0.034
Trypanosoma brucei heat shock protein, putative 0.0034 0.018 0.0355
Loa Loa (eye worm) TOPoisomerase family member 0.0094 0.0629 0.1533
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0064 0.0134
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0065 0.0414 0.188
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0233 0.3564
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0036 0.0618
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0139 0.0959 0.232
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0049 0.0576
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0139 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0175 0.1233 0.3007
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Leishmania major cathepsin L-like protease 0.0062 0.0389 0.087
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.0036 0.0138
Schistosoma mansoni hypothetical protein 0.0178 0.125 0.1242
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0473 0.0464
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0136 0.0136
Entamoeba histolytica hypothetical protein 0.0035 0.0188 0.289
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.0036 0.0138
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.0036 0.0138
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.018 0.0355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0245
Echinococcus multilocularis musashi 0.0026 0.0123 0.0123
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0094 0.0629 0.1514
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0139 0.0959 0.2337
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0188 0.0179
Onchocerca volvulus 0.0013 0.0028 0.0088
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0065 0.0414 0.0405
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0063 0.0067
Toxoplasma gondii GAF domain-containing protein 0.0023 0.0103 0.055
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0018 0.0063 0.0063
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0373 0.0373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.0036 0.0138
Onchocerca volvulus Bile acid receptor homolog 0.0301 0.2164 1
Echinococcus granulosus para nitrobenzyl esterase 0.0013 0.0028 0.0028
Plasmodium vivax vivapain-2 0.0016 0.0049 0.0576
Schistosoma mansoni nuclear receptor nhr-48 0.0065 0.0414 0.0405
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0063 0.0067
Loa Loa (eye worm) hypothetical protein 0.0301 0.2164 0.5275
Schistosoma mansoni loxhd1 0.0061 0.0384 0.0376
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0103 0.2518
Mycobacterium ulcerans DNA gyrase subunit B 0.0052 0.0314 0.8487
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0063 0.0067
Brugia malayi steroid hormone receptor 0.0139 0.0959 0.232
Leishmania major cathepsin L-like protease 0.0062 0.0389 0.087
Loa Loa (eye worm) hypothetical protein 0.0059 0.0367 0.0894
Mycobacterium ulcerans two component sensor kinase MprB 0.0034 0.018 0.4702
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0188 0.0188
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0188 0.0438
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0139 0.0959 0.4406
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0064 0.0064
Mycobacterium ulcerans two component regulator - sensor kinase 0.0034 0.018 0.4702
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0188 0.1107
Onchocerca volvulus 0.0035 0.0188 0.0832
Brugia malayi nuclear receptor NHR-67 0.0065 0.0414 0.099
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0018 0.0063 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Echinococcus granulosus geminin 0.0178 0.125 0.125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0139 0.0959 0.232
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0099 0.0155
Leishmania major cathepsin L-like protease 0.0062 0.0389 0.087
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0083 0.0544 0.1249
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0245
Echinococcus granulosus Nuclear hormone receptor HR96 0.0065 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Brugia malayi conserved hypotetical protein 0.0065 0.0414 0.099
Schistosoma mansoni microtubule-associated protein tau 0.1354 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0139 0.0959 0.232
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0018 0.0063 0.0799
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0018 0.0063 0.0054
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0188 0.1107
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0139 0.0959 0.095
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0034 0.018 0.4702
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0188 0.0188
Schistosoma mansoni pyruvate dehydrogenase 0.0561 0.4102 0.4097
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0049 0.0646
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0034 0.018 0.1053
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0034 0.018 0.1053
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.0036 0.0138
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0018 0.0063 0.0153
Echinococcus multilocularis Polycystic kidney disease protein 0.0061 0.0384 0.0384
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0473 0.1132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.087
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0083 0.0544 0.3267
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0139 0.0959 0.095
Onchocerca volvulus 0.0231 0.1645 0.7593
Trichomonas vaginalis receptor histidine kinase, putative 0.0034 0.018 0.1044
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0049 0.012
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0195 0.138 0.3306
Trypanosoma brucei heat shock protein, putative 0.0034 0.018 0.0355
Mycobacterium ulcerans hypothetical protein 0.0035 0.0188 0.4943
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0064 0.0336
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0188 0.1107
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0399 0.2893 0.2887
Echinococcus multilocularis para nitrobenzyl esterase 0.0013 0.0028 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.0036 0.0138
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0373 0.0829
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0064 0.007
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0064 0.0887
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0072 0.0461 0.0452
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0049 0.0245
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.018 0.0355
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0188 0.0188
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0367 0.0358
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.018 0.1027
Brugia malayi CXXC zinc finger family protein 0.0028 0.0135 0.0306
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0018 0.0063 0.0067
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0034 0.018 0.1053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0139 0.0959 0.2337
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.1603 0.3907
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0036 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0409 0.2443
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0139 0.0959 0.0959
Mycobacterium leprae Probable two-component sensor kinase 0.0034 0.018 0.9442
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0049 0.0049
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0139 0.0959 0.095
Echinococcus multilocularis microtubule associated protein 2 0.1354 1 1
Schistosoma mansoni nuclear hormone receptor 0.0139 0.0959 0.095
Loa Loa (eye worm) acetylcholinesterase 1 0.008 0.052 0.1268
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0018 0.0063 0.0067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0139 0.0959 0.232
Loa Loa (eye worm) cysteine protease 0.0016 0.0049 0.012
Brugia malayi Cytochrome P450 family protein 0.0014 0.0036 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0139 0.0959 0.232
Onchocerca volvulus 0.0035 0.0188 0.0832
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0139 0.0959 0.232
Loa Loa (eye worm) doublecortin family protein 0.0061 0.0384 0.0937
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0065 0.0414 0.0414
Echinococcus granulosus lamin 0.0026 0.0123 0.0123
Echinococcus multilocularis heat shock protein 90 0.0034 0.018 0.018
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0018 0.0063 0.0063
Trypanosoma brucei heat shock protein, putative 0.0034 0.018 0.0355
Schistosoma mansoni rab6-interacting 0.0061 0.0384 0.0376
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0018 0.0063 0.0799
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0344 0.249 0.2483
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0833 0.0833
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0389 0.087
Plasmodium vivax phosphodiesterase gamma, putative 0.0018 0.0063 0.0799
Trichomonas vaginalis heat shock protein, putative 0.0034 0.018 0.1044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0064 0.007
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0018 0.0063 0.0054
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0088 0.0579 0.1337
Loa Loa (eye worm) hypothetical protein 0.0035 0.0188 0.046
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.0036 0.0138
Echinococcus multilocularis cysteine protease 0.0016 0.0049 0.0049
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0083 0.0544 0.3267
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0073 0.0473 0.0473
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0374 0.0365
Schistosoma mansoni intermediate filament proteins 0.0026 0.0123 0.0114
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.087
Schistosoma mansoni gliotactin 0.0013 0.0028 0.0019
Schistosoma mansoni pyruvate dehydrogenase 0.0527 0.385 0.3845
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0034 0.018 0.1044
Brugia malayi ecdysteroid receptor 0.0301 0.2164 0.5264
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0013 0.0028 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0149 0.0139
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0059 0.0369 0.2199
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.0036 0.0138
Brugia malayi Steroid receptor seven-up type 2 0.0139 0.0959 0.232
Schistosoma mansoni hypothetical protein 0.0035 0.0188 0.0179
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0195 0.138 0.8444
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0083 0.0544 0.0544
Echinococcus multilocularis BC026374 protein (S09 family) 0.0013 0.0028 0.0028
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0373 0.0373
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0414 0.0414
Trichomonas vaginalis DNA topoisomerase II, putative 0.0094 0.0629 0.3787
Brugia malayi nuclear hormone receptor 0.0065 0.0414 0.099
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0579 0.9199
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0083 0.0544 0.3267
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0034 0.018 0.1053
Brugia malayi Carboxylesterase family protein 0.0013 0.0028 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0355 0.2107
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0367 0.224
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0344 0.249 0.6071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0245
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0344 0.249 0.249
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0139 0.0959 0.0959
Schistosoma mansoni lipoxygenase 0.0172 0.1206 0.1198
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Loa Loa (eye worm) hypothetical protein 0.0073 0.0473 0.1152
Echinococcus granulosus cpg binding protein 0.0029 0.0146 0.0146
Brugia malayi Carboxylesterase family protein 0.0013 0.0028 0.0046
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0049 0.0186
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0013 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0103 0.0572
Schistosoma mansoni heat shock protein 0.0034 0.018 0.0171
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0036 0.0618
Schistosoma mansoni pyruvate dehydrogenase 0.0527 0.385 0.3845
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0034 0.018 0.4151
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0544 0.3267
Loa Loa (eye worm) PDE1B protein 0.0239 0.1706 0.416
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0833 0.0833
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0473 0.1132
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0063 0.0328
Schistosoma mansoni ap endonuclease 0.0018 0.0064 0.0055
Mycobacterium tuberculosis Conserved protein 0.0035 0.0188 0.1107
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0042 0.0238 0.1396
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0373 0.2222
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0022 0.0022
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Loa Loa (eye worm) hypothetical protein 0.0139 0.0959 0.2337
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0149 0.0139
Loa Loa (eye worm) hypothetical protein 0.008 0.052 0.1268
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0072 0.0461 0.1047
Loa Loa (eye worm) hypothetical protein 0.0073 0.0473 0.1152
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0018 0.0063 0.0067
Onchocerca volvulus 0.0065 0.0414 0.188
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0233 0.4268
Mycobacterium leprae Probable lipase LipE 0.0035 0.0188 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0367 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.0036 0.0138
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0083 0.0544 0.3267
Trichomonas vaginalis heat shock protein, putative 0.0034 0.018 0.1044
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0018 0.0063 0.0799
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0188 1
Brugia malayi nuclear hormone receptor 0.0139 0.0959 0.232
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0034 0.018 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0139 0.0959 0.232
Plasmodium falciparum phosphodiesterase gamma, putative 0.0018 0.0063 0.0799
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0367 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0414 0.0414
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0088 0.0579 0.1337
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0367 0.0815
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0373 0.2222
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0083 0.0544 0.1249
Schistosoma mansoni hypothetical protein 0.0014 0.0036 0.0026
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0414 0.0405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0245
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.0036 0.0138
Echinococcus granulosus lamin dm0 0.0026 0.0123 0.0123
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0049 0.0033
Brugia malayi Pre-SET motif family protein 0.0203 0.1437 0.3489
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0052 0.0314 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0036 0.0618
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0373 0.0829
Brugia malayi beta-lactamase 0.0035 0.0188 0.0438
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0461 0.0461
Onchocerca volvulus 0.0028 0.0135 0.0582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.087
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0036 0.0618
Plasmodium falciparum endoplasmin, putative 0.0034 0.018 0.2702
Schistosoma mansoni hypothetical protein 0.0178 0.125 0.1242
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0461 0.0461
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0018 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0139 0.0959 0.232
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Onchocerca volvulus 0.0016 0.0049 0.0186
Brugia malayi hypothetical protein 0.0013 0.0028 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.087
Echinococcus multilocularis nuclear receptor nhr 48 0.0065 0.0414 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0409 0.2443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0034 0.018 0.4702
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0042 0.0238 0.0558
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0036 0.0135
Loa Loa (eye worm) hypothetical protein 0.0042 0.0243 0.0593
Trichomonas vaginalis endoplasmin, putative 0.0034 0.018 0.1044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2867 0.2867
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0034 0.018 0.1044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0188 0.046
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0034 0.018 0.554
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0373 0.0829
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0018 0.0063 0.0328
Echinococcus multilocularis cysteine protease 0.0016 0.0049 0.0049
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0049 0.0576
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0123 0.0278
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.087
Echinococcus multilocularis neuroligin 0.0013 0.0028 0.0028
Schistosoma mansoni cpg binding protein 0.0029 0.0146 0.0137
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0052 0.0314 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.1059 0.2564
Mycobacterium leprae Probable two component sensor kinase MprB 0.0034 0.018 0.9442
Brugia malayi hypothetical protein 0.0073 0.0473 0.1132
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0099 0.0155
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0123 0.03
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0367 0.0358
Schistosoma mansoni thyroid hormone receptor 0.026 0.1863 0.1856
Echinococcus granulosus nuclear receptor nhr 48 0.0065 0.0414 0.0414
Mycobacterium tuberculosis Conserved protein 0.0034 0.018 0.1053
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0099 0.024
Brugia malayi hypothetical protein 0.0061 0.0384 0.0917
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.1027 0.1027
Trichomonas vaginalis spcc417.12 protein, putative 0.0013 0.0028 0.0116
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0229 0.1632 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0018 0.0063 0.0067
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.018 0.0355
Plasmodium vivax hypothetical protein, conserved 0.0034 0.018 0.2702
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0018 0.0063 0.0054
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0018 0.0063 0.0328
Plasmodium vivax DNA gyrase subunit B, putative 0.0052 0.0314 0.4877
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.018 0.2938
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0139 0.0959 0.2337
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0073 0.0473 0.0473
Loa Loa (eye worm) carboxylesterase 0.008 0.052 0.1268
Giardia lamblia Pms1-like protein 0.0034 0.018 0.2938
Schistosoma mansoni thyroid hormone receptor 0.026 0.1863 0.1856
Trypanosoma cruzi DNA topoisomerase II, putative 0.0088 0.0581 0.1342
Onchocerca volvulus 0.0016 0.0049 0.0186
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0083 0.0544 0.3267
Leishmania major cathepsin L-like protease 0.0016 0.0049 0.0033
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0018 0.0063 0.0067
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0034 0.018 0.554
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0088 0.0579 0.1337
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0069
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0094 0.0629 0.0629
Loa Loa (eye worm) hypothetical protein 0.0139 0.0959 0.2337
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0139 0.0959 0.2337
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0042 0.0238 0.1396
Brugia malayi Cathepsin L-like precursor 0.0016 0.0049 0.0098
Loa Loa (eye worm) cytochrome P450 0.0014 0.0036 0.0087
Loa Loa (eye worm) nuclear hormone receptor 0.0065 0.0414 0.101
Echinococcus multilocularis heat shock protein 0.0034 0.018 0.018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0139 0.0959 0.0959
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0139 0.0959 0.0959
Leishmania major DNA topoisomerase ii 0.0088 0.0581 0.1342
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0344 0.249 0.6062
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0414 0.0405
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0049 0.0098
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0135 0.0328
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0034 0.018 0.1044
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0065 0.0414 0.0414
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0083 0.0544 0.1249
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0579 0.3496
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0049 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0139 0.0959 0.232
Loa Loa (eye worm) carboxylesterase 0.0013 0.0028 0.0069
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.018 0.0355
Brugia malayi orphan nuclear receptor NR2E1 0.0065 0.0414 0.099
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0052 0.0314 0.1853
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0188 0.4943
Loa Loa (eye worm) hypothetical protein 0.0035 0.0188 0.046
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0373 0.2222
Onchocerca volvulus 0.0016 0.0049 0.0186
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0188 0.0179
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0077 0.05 0.2276
Toxoplasma gondii hypothetical protein 0.0023 0.0103 0.055
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.0036 0.0138
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.0251
Echinococcus granulosus acetylcholinesterase 0.008 0.052 0.052
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Onchocerca volvulus 0.0013 0.0028 0.0088
Leishmania major hypothetical protein, conserved 0.0035 0.0188 0.0376
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0149 0.0149
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0013 0.0028 0.0028
Toxoplasma gondii ABC1 family protein 0.0035 0.0188 0.1079
Echinococcus multilocularis acetylcholinesterase 0.008 0.052 0.052
Plasmodium falciparum phosphodiesterase delta, putative 0.0018 0.0063 0.0799
Trypanosoma brucei heat shock protein, putative 0.0034 0.018 0.0355
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Brugia malayi Nuclear hormone receptor E75 0.0065 0.0414 0.099
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.0103 0.1447
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0036 0.0618
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0064 0.007
Plasmodium falciparum DNA gyrase subunit B 0.0052 0.0314 0.4877
Echinococcus multilocularis 0.0014 0.0036 0.0036
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0461 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0063 0.0328
Loa Loa (eye worm) DR-78 0.0065 0.0414 0.101
Brugia malayi nuclear receptor NHR-88 0.0065 0.0414 0.099
Onchocerca volvulus 0.0016 0.0049 0.0186
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0042 0.0238 0.0238
Trypanosoma brucei protein kinase, putative 0.006 0.0373 0.0829
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Trichomonas vaginalis sensor histidine kinase, putative 0.0034 0.018 0.1044
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0188 0.1107
Echinococcus multilocularis ubiquitin specific protease 41 0.0072 0.0461 0.0461
Mycobacterium ulcerans carboxylesterase, LipT 0.0013 0.0028 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0139 0.0959 0.232
Onchocerca volvulus 0.0026 0.0123 0.0529
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.1059 0.1059
Loa Loa (eye worm) hypothetical protein 0.0042 0.0243 0.0593
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.0036 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0245
Loa Loa (eye worm) hypothetical protein 0.0061 0.0384 0.0937
Brugia malayi Probable DNA topoisomerase II 0.0094 0.0629 0.1514
Plasmodium falciparum LCCL domain-containing protein 0.0061 0.0384 0.6027
Leishmania major heat shock protein 83-1 0.0034 0.018 0.0355
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0034 0.018 0.4702
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0373 0.0829
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.018 0.0355
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0046
Brugia malayi Cathepsin L-like precursor 0.0016 0.0049 0.0098
Onchocerca volvulus 0.0016 0.0049 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0245
Loa Loa (eye worm) hypothetical protein 0.0139 0.0959 0.2337
Echinococcus granulosus cathepsin l1 0.0016 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0139 0.0959 0.232
Echinococcus multilocularis carboxylesterase 5A 0.008 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0139 0.0959 0.2337
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0139 0.0959 0.095
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0018 0.0063 0.0328
Echinococcus granulosus RUN 0.0061 0.0384 0.0384
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0083 0.0544 0.3267
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0049 0.0186
Brugia malayi nuclear receptor NHR-88 0.0139 0.0959 0.232
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0239 0.1706 0.1699
Echinococcus multilocularis ecdysone induced protein 78C 0.0139 0.0959 0.0959
Echinococcus multilocularis acetylcholinesterase 0.008 0.052 0.052
Onchocerca volvulus 0.0061 0.0384 0.1741
Onchocerca volvulus 0.003 0.0149 0.0646
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0034 0.018 0.1044
Loa Loa (eye worm) endoplasmin 0.0034 0.018 0.0439
Onchocerca volvulus 0.0035 0.0188 0.0832
Schistosoma mansoni lamin 0.0026 0.0123 0.0114
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0018 0.0063 0.0328
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0373 0.2222
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0188 0.1096
Loa Loa (eye worm) hypothetical protein 0.0065 0.0414 0.101
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.087
Onchocerca volvulus 0.0026 0.0123 0.0529
Echinococcus granulosus FTZ F1 alpha 0.0139 0.0959 0.0959
Loa Loa (eye worm) ctsf protein 0.0016 0.0049 0.012
Leishmania major hypothetical protein, conserved 0.0034 0.018 0.0355
Schistosoma mansoni hypothetical protein 0.0061 0.0384 0.0376
Brugia malayi beta-lactamase family protein 0.0035 0.0188 0.0438
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.0036 0.0138
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0103 0.2518
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.0384 0.0384
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0072 0.0461 0.7297
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0042 0.0238 0.0229
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0064 0.1678
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0139 0.0959 0.095
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0069
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0188 0.0179
Plasmodium vivax DNA topoisomerase II, putative 0.0094 0.0629 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0065 0.0414 0.099
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.018 0.0355
Entamoeba histolytica DNA topoisomerase II, putative 0.0094 0.0629 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0239 0.1706 0.1706
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0139 0.0959 0.232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.087
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0018 0.0063 0.0799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0389 0.087
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0261 0.1525
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.0036 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0149 0.0139
Brugia malayi nuclear hormone receptor family member odr-7 0.0065 0.0414 0.099
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.0384 0.0384
Schistosoma mansoni rab6-interacting 0.0061 0.0384 0.0376
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0036 0.0618
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0344 0.249 0.249
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0373 0.0364
Brugia malayi hypothetical protein 0.0073 0.0473 0.1132
Schistosoma mansoni lamin 0.0026 0.0123 0.0114
Loa Loa (eye worm) hypothetical protein 0.0072 0.0461 0.1124
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0099 0.0155
Loa Loa (eye worm) hypothetical protein 0.0061 0.0384 0.0937
Loa Loa (eye worm) hypothetical protein 0.0139 0.0959 0.2337
Mycobacterium tuberculosis Probable two component sensor kinase 0.0034 0.018 0.1053
Echinococcus multilocularis lamin 0.0026 0.0123 0.0123
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0373 0.2218
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0054
Schistosoma mansoni retinoic acid receptor RXR 0.0139 0.0959 0.095
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0049 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0149 0.0139
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304
Loa Loa (eye worm) hypothetical protein 0.0035 0.0188 0.046
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0088 0.0581 0.1342
Schistosoma mansoni hypothetical protein 0.0122 0.0833 0.0824
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0069
Mycobacterium tuberculosis Conserved protein 0.0035 0.0188 0.1107
Loa Loa (eye worm) hypothetical protein 0.0059 0.0367 0.0894
Entamoeba histolytica hypothetical protein 0.0035 0.0188 0.289
Brugia malayi hypothetical protein 0.0061 0.0384 0.0917
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0063 0.0304

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.48 Inhibition of PDE5 ChEMBL. 18656371
IC50 (binding) = 330 nM Inhibition of Phosphodiesterase 5 from human corpus cavernosum ChEMBL. No reference
IC50 (binding) = 330 nM Inhibition of Phosphodiesterase 5 from human corpus cavernosum ChEMBL. No reference
IC50 (binding) = 3300 nM Inhibition of Phosphodiesterase 1 from rat liver ChEMBL. No reference
IC50 (binding) = 3300 nM Inhibition of Phosphodiesterase 1 from rat liver ChEMBL. No reference
IC50 (binding) > 100 uM Inhibition of Phosphodiesterase 3 from rabbit platelets ChEMBL. No reference
IC50 (binding) > 100 uM Inhibition of Phosphodiesterase 3 from rabbit platelets ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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