Detailed information for compound 802962

Basic information

Technical information
  • TDR Targets ID: 802962
  • Name: N-(3-methoxypropyl)-5-methyl-2-phenylpyrazole -3-carboxamide
  • MW: 273.33 | Formula: C15H19N3O2
  • H donors: 1 H acceptors: 2 LogP: 2.11 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCNC(=O)c1cc(nn1c1ccccc1)C
  • InChi: 1S/C15H19N3O2/c1-12-11-14(15(19)16-9-6-10-20-2)18(17-12)13-7-4-3-5-8-13/h3-5,7-8,11H,6,9-10H2,1-2H3,(H,16,19)
  • InChiKey: WMWPUHMFQIKOPT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-methoxypropyl)-5-methyl-2-phenyl-pyrazole-3-carboxamide
  • N-(3-methoxypropyl)-5-methyl-2-phenyl-3-pyrazolecarboxamide
  • MLS000731030
  • N-(3-methoxypropyl)-3-methyl-1-phenyl-1H-pyrazole-5-carboxamide
  • SMR000309405

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.0709 0.1057
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0128 0.0511 0.0895
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0144 0.0217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0358 0.0351
Giardia lamblia Phosphoglycerate kinase 0.0702 0.3107 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0023 0.0012
Toxoplasma gondii HEAT repeat-containing protein 0.0064 0.0225 0.0674
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.012 0.0181
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0053 0.0093
Onchocerca volvulus 0.0097 0.0372 0.1622
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0198 0.0829 0.1453
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0181 0.075 0.2373
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0047 0.006
Plasmodium falciparum thioredoxin reductase 0.0128 0.0511 0.1581
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0128 0.0511 0.0895
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0068
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0128 0.0511 0.0503
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0074 0.0066
Brugia malayi N-terminal motif family protein 0.0207 0.0871 0.13
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0087 0.0152
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0044 0.0085
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0034 0.0087 0.0279
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0087 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.002 0.003
Brugia malayi polybromodomain protein 0.0017 0.0011 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0044 0.013 0.0196
Trichomonas vaginalis glutamate synthase, putative 0.0034 0.0087 0.013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0197 0.0189
Leishmania major NADH dehydrogenase, putative 0.0034 0.0087 0.0152
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.004 0.0115 0.0202
Schistosoma mansoni importin beta-1 0.0064 0.0225 0.0217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0066 0.0231 0.0347
Trypanosoma brucei hypothetical protein, conserved 0.0138 0.0556 0.0975
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0034 0.0087 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.012 0.0181
Schistosoma mansoni myst-related protein 0.0021 0.0031 0.0023
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0055 0.0082
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0053 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0241 0.0233
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0098 0.0136
Echinococcus granulosus bloom syndrome protein 0.0028 0.0058 0.005
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0128 0.0511 0.0503
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0053 0.0068
Trichomonas vaginalis CAMK family protein kinase 0.0511 0.2245 0.3378
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0054
Mycobacterium ulcerans lipase LipD 0.0036 0.0098 0.0113
Trypanosoma brucei glucosidase, putative 0.0038 0.0106 0.0185
Mycobacterium ulcerans phosphoglycerate kinase 0.0702 0.3107 0.4656
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0047 0.004
Mycobacterium leprae Probable lipase LipE 0.0036 0.0098 0.0109
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.009 0.0158
Schistosoma mansoni chromobox protein 0.0149 0.0609 0.0601
Trypanosoma cruzi NADH dehydrogenase, putative 0.0034 0.0087 0.0152
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0074 0.0181
Loa Loa (eye worm) thioredoxin reductase 0.0368 0.1599 0.2396
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0034 0.0087 0.0152
Toxoplasma gondii selenide, water dikinase 0.0034 0.0087 0.0226
Onchocerca volvulus 0.0099 0.0382 0.1667
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0128 0.0511 0.1581
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0056 0.0186 0.0547
Trypanosoma brucei DNA polymerase kappa, putative 0.0349 0.1511 0.2649
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0044 0.0036
Onchocerca volvulus 0.0036 0.0098 0.0397
Leishmania major hypothetical protein, conserved 0.0026 0.0052 0.0092
Trypanosoma cruzi trypanothione reductase, putative 0.0128 0.0511 0.0895
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0034 0.0087 0.0096
Trichomonas vaginalis helicase, putative 0.0041 0.012 0.0181
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0034 0.0087 0.0152
Brugia malayi Thioredoxin reductase 0.0368 0.1599 0.2396
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0034 0.0087 0.0119
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0034 0.0087 0.0152
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0197 0.0345
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0444 0.1939 0.1933
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0098 0.0172
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0047 0.0148 0.0422
Brugia malayi acetyltransferase, GNAT family protein 0.0328 0.1417 0.2122
Mycobacterium tuberculosis Conserved hypothetical protein 0.0444 0.1939 0.4642
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0168 0.0242
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0702 0.3107 0.4674
Trypanosoma brucei ISWI complex protein 0.0019 0.002 0.0035
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0044 0.0036
Brugia malayi serine/threonine-protein kinase plk-2 0.0511 0.2245 0.337
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0212 0.0205
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0034 0.0087 0.0079
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0034 0.0087 0.0279
Trichomonas vaginalis glutamate synthase, putative 0.0034 0.0087 0.013
Plasmodium vivax flap endonuclease 1, putative 0.0056 0.0186 0.0544
Trypanosoma brucei DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0029 0.0038
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0024 0.0044 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Entamoeba histolytica hypothetical protein 0.0024 0.0044 0.0141
Trichomonas vaginalis rotamase, putative 0.0036 0.0094 0.0141
Brugia malayi ImpB/MucB/SamB family protein 0.0444 0.1939 0.2908
Trypanosoma brucei DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Giardia lamblia Thioredoxin reductase 0.0034 0.0087 0.0105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0358 0.0351
Schistosoma mansoni cpg binding protein 0.0261 0.1112 0.1105
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0198 0.0829 0.1453
Loa Loa (eye worm) hypothetical protein 0.011 0.0433 0.064
Onchocerca volvulus 0.0024 0.0044 0.0156
Treponema pallidum NADH oxidase 0.0128 0.0511 0.1403
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0258 0.1099 0.1926
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1276 0.5703 1
Brugia malayi mbt repeat family protein 0.0097 0.0372 0.0549
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0044 0.0066
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0034 0.0087 0.0119
Brugia malayi beta-lactamase 0.0036 0.0098 0.0136
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0128 0.0511 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0044 0.0066
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0044 0.0054
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0106 0.0159
Echinococcus multilocularis SAM and MBT domain containing protein 0.0097 0.0372 0.0365
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0197 0.0189
Mycobacterium ulcerans monoxygenase 0.0034 0.0087 0.0096
Loa Loa (eye worm) hypothetical protein 0.0686 0.3035 0.4559
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0097 0.037 0.1139
Trypanosoma cruzi DNA damage repair protein, putative 0.0138 0.0556 0.0975
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0047 0.0148 0.0425
Mycobacterium ulcerans hypothetical protein 0.0036 0.0098 0.0113
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1276 0.5703 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0197 0.058
Echinococcus multilocularis expressed protein 0.0036 0.0094 0.0086
Echinococcus granulosus histone acetyltransferase MYST2 0.011 0.0433 0.0425
Trichomonas vaginalis CAMK family protein kinase 0.0511 0.2245 0.3378
Trypanosoma brucei DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0128 0.0511 0.0895
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0023
Trypanosoma brucei polo-like protein kinase 0.0511 0.2245 0.3937
Trichomonas vaginalis CAMK family protein kinase 0.0511 0.2245 0.3378
Trypanosoma cruzi DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0066 0.0231 0.0347
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0034 0.0087 0.013
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0097 0.037 0.1142
Echinococcus granulosus glutamate synthase 0.0034 0.0087 0.0079
Entamoeba histolytica hypothetical protein 0.0052 0.017 0.0547
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0223 0.039
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0047 0.0083
Trypanosoma brucei DNA damage repair protein, putative 0.0138 0.0556 0.0975
Onchocerca volvulus 0.0078 0.0288 0.1245
Brugia malayi Bromodomain containing protein 0.0018 0.0017 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0066 0.0231 0.0347
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0097 0.037 0.1142
Trypanosoma brucei DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Loa Loa (eye worm) hypothetical protein 0.0064 0.0225 0.0327
Plasmodium vivax DNA repair protein REV1, putative 0.0138 0.0556 0.1742
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0034 0.0087 0.0166
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0106 0.0098
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0052 0.0092
Loa Loa (eye worm) hypothetical protein 0.0139 0.0561 0.0833
Plasmodium vivax thioredoxin reductase, putative 0.0368 0.1599 0.5117
Trichomonas vaginalis bromodomain-containing protein, putative 0.0097 0.037 0.0556
Leishmania major hypothetical protein, conserved 0.0027 0.0055 0.0096
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0052 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0487 0.2133 0.3741
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0044 0.0036
Toxoplasma gondii exonuclease III APE 0.0058 0.0197 0.0583
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0444 0.1939 0.1933
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0709 0.0702
Trichomonas vaginalis set domain proteins, putative 0.0512 0.2248 0.3381
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0098 0.0113
Schistosoma mansoni chromobox protein 0.0024 0.0044 0.0036
Brugia malayi glutaminase DH11.1 0.1485 0.6648 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0053 0.0046
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0034 0.0087 0.0223
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0172 0.0712 0.2233
Plasmodium falciparum zinc finger protein, putative 0.0021 0.0031 0.0025
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0223 0.0215
Schistosoma mansoni hypothetical protein 0.0036 0.0094 0.0086
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0136
Loa Loa (eye worm) glutaminase 2 0.1485 0.6648 1
Plasmodium vivax SET domain protein, putative 0.0068 0.0241 0.0722
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.084 0.3732 0.8976
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0055 0.0096
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0098 0.009
Onchocerca volvulus 0.0036 0.0098 0.0397
Brugia malayi jmjC domain containing protein 0.0025 0.0047 0.006
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0328 0.1417 0.141
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0198 0.0829 0.0822
Plasmodium falciparum phd finger protein, putative 0.0031 0.0074 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0044 0.0066
Loa Loa (eye worm) hypothetical protein 0.0026 0.0052 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0044 0.0066
Brugia malayi jmjC domain containing protein 0.0025 0.0047 0.006
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0047 0.004
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0106 0.0159
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0106 0.034
Trichomonas vaginalis CAMK family protein kinase 0.0511 0.2245 0.3378
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0097 0.0372 0.0365
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0034 0.0087 0.0152
Loa Loa (eye worm) glutathione reductase 0.0368 0.1599 0.2396
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.011 0.0433 0.0425
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0068 0.0241 0.0725
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0034 0.0087 0.0082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0128 0.0511 0.0895
Trypanosoma brucei unspecified product 0.0306 0.1317 0.2308
Mycobacterium ulcerans beta-lactamase 0.0036 0.0098 0.0113
Trypanosoma brucei chrX additional, unordered contigs 0.0138 0.0556 0.0975
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0702 0.3107 0.5449
Echinococcus multilocularis dna polymerase eta 0.0686 0.3035 0.303
Loa Loa (eye worm) programmed cell death 8 0.0034 0.0087 0.0119
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0043 0.0065
Schistosoma mansoni sex comb on midleg homolog 0.0097 0.0372 0.0365
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0034 0.0087 0.0166
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0094 0.0357 0.0526
Schistosoma mansoni cpg binding protein 0.025 0.1065 0.1058
Treponema pallidum phosphoglycerate kinase 0.0702 0.3107 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.002 0.003
Trichomonas vaginalis hypothetical protein 0.0022 0.0034 0.005
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0034 0.0087 0.0166
Giardia lamblia Kinase, PLK 0.0511 0.2245 0.7176
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0258 0.1099 0.1926
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0047 0.006
Schistosoma mansoni hypothetical protein 0.0602 0.2653 0.2648
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0312 0.0469
Plasmodium vivax ferrodoxin reductase, putative 0.0034 0.0087 0.0223
Onchocerca volvulus Alhambra homolog 0.0031 0.0074 0.0289
Loa Loa (eye worm) CXXC zinc finger family protein 0.025 0.1065 0.1592
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0034 0.0087 0.0226
Loa Loa (eye worm) hypothetical protein 0.0052 0.0168 0.0242
Loa Loa (eye worm) acetyltransferase 0.0328 0.1417 0.2122
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0053 0.0093
Entamoeba histolytica acetyltransferase, GNAT family 0.0088 0.0333 0.1073
Loa Loa (eye worm) glutaminase 0.1485 0.6648 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0062 0.0054
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0223 0.0215
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0197 0.0285
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0098 0.0147
Trypanosoma brucei unspecified product 0.0306 0.1317 0.2308
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0098 0.009
Brugia malayi Bromodomain containing protein 0.0039 0.011 0.0154
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0034 0.0087 0.0207
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0689 0.3046 0.4576
Giardia lamblia NADH oxidase lateral transfer candidate 0.0128 0.0511 0.1493
Mycobacterium ulcerans DNA polymerase IV 0.0617 0.2722 0.4075
Toxoplasma gondii hypothetical protein 0.0172 0.0712 0.2248
Trypanosoma cruzi polo-like protein kinase, putative 0.0511 0.2245 0.3937
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0013
Brugia malayi hypothetical protein 0.0026 0.0052 0.0067
Loa Loa (eye worm) hypothetical protein 0.0078 0.0288 0.0422
Loa Loa (eye worm) MBCTL1 0.011 0.0433 0.064
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0556 0.0975
Brugia malayi beta-lactamase family protein 0.0036 0.0098 0.0136
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0129 0.0121
Brugia malayi chromobox protein homolog 3 0.0084 0.0312 0.0458
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0066 0.0231 0.0347
Mycobacterium tuberculosis Conserved protein 0.0036 0.0098 0.0193
Giardia lamblia DNA damage repair protein 0.0138 0.0556 0.1642
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0044 0.0054
Leishmania major hypothetical protein, conserved 0.0036 0.0098 0.0172
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0047 0.01
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0934 0.4156 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0389 0.1691 0.1684
Mycobacterium ulcerans hypothetical protein 0.0026 0.0053 0.0046
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0511 0.2245 0.2239
Onchocerca volvulus 0.025 0.1065 0.4718
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.084 0.3732 0.8967
Trypanosoma brucei DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Chlamydia trachomatis phosphoglycerate kinase 0.0702 0.3107 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0053 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0201 0.0303
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0027 0.0055 0.0047
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0179 0.0745 0.1306
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0034 0.0087 0.013
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.0032 0.0024
Echinococcus multilocularis lysine specific demethylase 5A 0.0095 0.0361 0.0354
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0034 0.0087 0.0152
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0179 0.0745 0.1306
Schistosoma mansoni jumonji/arid domain-containing protein 0.0105 0.0408 0.0401
Mycobacterium tuberculosis Probable dehydrogenase 0.084 0.3732 0.8976
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0047 0.004
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0034 0.0087 0.0226
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0056 0.0186 0.0326
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0511 0.2245 0.3937
Trypanosoma brucei DNA polymerase kappa, putative 0.0349 0.1511 0.2649
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0487 0.2133 0.3741
Loa Loa (eye worm) hypothetical protein 0.0084 0.0312 0.0458
Loa Loa (eye worm) hypothetical protein 0.0068 0.0241 0.0351
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0128 0.0511 0.0895
Entamoeba histolytica phosphoglycerate kinase, putative 0.0702 0.3107 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0094 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.012 0.0181
Leishmania major DNA polymerase kappa, putative 0.0487 0.2133 0.3741
Leishmania major hypothetical protein, conserved 0.0034 0.0087 0.0152
Trypanosoma cruzi polo-like protein kinase, putative 0.0511 0.2245 0.3937
Schistosoma mansoni ap endonuclease 0.0058 0.0197 0.0189
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0034 0.0087 0.0082
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0097 0.037 0.0556
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0044 0.0066
Trichomonas vaginalis CAMK family protein kinase 0.0511 0.2245 0.3378
Schistosoma mansoni hypothetical protein 0.0024 0.0044 0.0036
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.004 0.0115 0.0315
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0047 0.0148 0.0211
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0018 0.0017 0.0009
Onchocerca volvulus Heterochromatin protein 1 homolog 0.009 0.0341 0.1482
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0106 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0098 0.0172
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0034 0.0087 0.013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0358 0.0528
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0197 0.0263
Leishmania major trypanothione reductase 0.0368 0.1599 0.2803
Echinococcus multilocularis phosphoglycerate kinase 1 0.0702 0.3107 0.3102
Echinococcus granulosus dna polymerase eta 0.0686 0.3035 0.303
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.006
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0047 0.004
Plasmodium falciparum thioredoxin reductase 0.0368 0.1599 0.5109
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0034 0.0087 0.0079
Trichomonas vaginalis apoptosis inducing factor, putative 0.0034 0.0087 0.013
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0035 0.0091 0.0083
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0034 0.0087 0.0079
Entamoeba histolytica hypothetical protein 0.0021 0.0031 0.0098
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0034 0.0087 0.0152
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.009 0.0158
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0053 0.0068
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0034 0.0087 0.0079
Leishmania major DNA polymerase eta, putative 0.038 0.1652 0.2896
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0052 0.0115
Trichomonas vaginalis hypothetical protein 0.0024 0.0044 0.0066
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Trypanosoma cruzi DNA damage repair protein, putative 0.0138 0.0556 0.0975
Plasmodium falciparum phosphoglycerate kinase 0.0702 0.3107 1
Loa Loa (eye worm) histone methyltransferase 0.0059 0.0199 0.0288
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0159 0.0651 0.0643
Echinococcus multilocularis polycomb protein SCMH1 0.0097 0.0372 0.0365
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0198 0.0829 0.0822
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0241 0.0233
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0052 0.0096
Mycobacterium ulcerans hypothetical protein 0.0672 0.2972 0.4452
Schistosoma mansoni serine/threonine protein kinase 0.0511 0.2245 0.2239
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0617 0.2722 0.4095
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0106 0.0185
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0511 0.2245 0.2239
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0098 0.0113
Trypanosoma brucei trypanothione reductase 0.0368 0.1599 0.2803
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0197 0.0345
Giardia lamblia Flap structure-specific endonuclease 0.0056 0.0186 0.043
Onchocerca volvulus 0.0066 0.023 0.0988
Echinococcus granulosus thioredoxin glutathione reductase 0.0373 0.1621 0.1615
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0044 0.0036
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0034 0.0087 0.0279
Loa Loa (eye worm) CHromoDomain protein family member 0.0035 0.0091 0.0125
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0098 0.0147
Echinococcus multilocularis snurportin 1 0.0689 0.3046 0.3041
Mycobacterium tuberculosis Conserved protein 0.0036 0.0098 0.0193
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0106 0.034
Plasmodium falciparum importin beta, putative 0.0064 0.0225 0.0656
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0219 0.0922 0.1617
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0034 0.0087 0.0096
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0074 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0066 0.0231 0.0347
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0358 0.0351
Entamoeba histolytica hypothetical protein 0.0024 0.0044 0.0141
Trichomonas vaginalis mercuric reductase, putative 0.0128 0.0511 0.0768
Echinococcus granulosus transcription factor Dp 1 0.0115 0.0452 0.0444
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0052 0.0112
Trichomonas vaginalis dullard protein, putative 0.0027 0.0055 0.0082
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.004 0.0115 0.0107
Onchocerca volvulus 0.0024 0.0044 0.0156
Trypanosoma brucei phosphoglycerate kinase 0.0702 0.3107 0.5449
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0023 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0054
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0053 0.0046
Giardia lamblia DINP protein human, muc B family 0.0487 0.2133 0.6809
Echinococcus multilocularis chromobox protein 2 0.0024 0.0044 0.0036
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0702 0.3107 1
Brugia malayi polk-prov protein 0.0311 0.1339 0.2005
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0034 0.0087 0.0279
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0098 0.0193
Leishmania major mitochondrial DNA polymerase beta 0.1276 0.5703 1
Brugia malayi Phosphoglycerate kinase 0.0258 0.1099 0.1643
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0128 0.0511 0.1581
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0047 0.004
Leishmania major GTP-binding protein, putative 0.0047 0.0148 0.026
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0094 0.013
Trypanosoma cruzi DNA polymerase eta, putative 0.038 0.1652 0.2896
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0394 0.1715 0.1709
Schistosoma mansoni hypothetical protein 0.0348 0.1507 0.1501
Echinococcus multilocularis geminin 0.0348 0.1507 0.1501
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0106 0.0159
Trypanosoma brucei DNA polymerase eta, putative 0.0686 0.3035 0.5322
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.009 0.0158
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0047 0.0148 0.0306
Echinococcus granulosus phd:f box containing protein 0.0025 0.0047 0.004
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0034 0.0087 0.013
Trypanosoma brucei NADH dehydrogenase 0.0034 0.0087 0.0152
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0044 0.0066
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0027 0.0055 0.0047
Echinococcus multilocularis glutamate synthase 0.0034 0.0087 0.0079
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0098 0.009
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0034 0.0087 0.0082
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0106 0.0147
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0094 0.0357 0.0526
Echinococcus granulosus cpg binding protein 0.0261 0.1112 0.1105
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0128 0.0511 0.0895
Echinococcus multilocularis chromobox protein 1 0.0149 0.0609 0.0601
Schistosoma mansoni SET domain protein 0.0017 0.0009 0.0001
Entamoeba histolytica Flap nuclease, putative 0.0056 0.0186 0.0598
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0128 0.0511 0.0895
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0197 0.0633
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0444 0.1939 0.2908
Schistosoma mansoni chromobox protein 0.0149 0.0609 0.0601
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0098 0.0193
Brugia malayi Bloom's syndrome protein homolog 0.0028 0.0058 0.0076
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0128 0.0511 0.1403
Mycobacterium tuberculosis Probable reductase 0.084 0.3732 0.8976
Brugia malayi jmjC domain containing protein 0.0105 0.0408 0.0603
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0055 0.0082
Plasmodium falciparum ferrodoxin reductase-like protein 0.0034 0.0087 0.0207
Echinococcus multilocularis DNA methyltransferase 2, putative 0.004 0.0115 0.0107
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0053 0.0171
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0136
Echinococcus granulosus DNA methyltransferase 2, putative 0.004 0.0115 0.0107
Schistosoma mansoni glutamate synthase 0.0034 0.0087 0.0079
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0027 0.0055 0.012
Loa Loa (eye worm) hypothetical protein 0.0068 0.0243 0.0354
Mycobacterium ulcerans ferredoxin reductase 0.0034 0.0087 0.0096
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0148 0.026
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0027 0.0055 0.0103
Leishmania major hypothetical protein, conserved 0.0034 0.0087 0.0152
Echinococcus granulosus zinc finger protein 0.0018 0.0017 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0253 0.1078 0.1621
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0056 0.0186 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.0311 0.1339 0.2348
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0029 0.0022
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0129 0.0121
Echinococcus granulosus disco interacting protein 2 0.0079 0.0293 0.0285
Loa Loa (eye worm) hypothetical protein 0.0207 0.0871 0.13
Toxoplasma gondii hypothetical protein 0.0206 0.0864 0.2741
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0047 0.01
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0034 0.0087 0.013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0054
Brugia malayi PHD-finger family protein 0.0031 0.0074 0.0099
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0128 0.0511 0.1598
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0047 0.0148 0.014
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0034 0.0087 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.012 0.0181
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0198 0.0829 0.1453
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.002
Trichomonas vaginalis DNA helicase recq1, putative 0.0028 0.0058 0.0087
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0044 0.0036
Plasmodium vivax JmjC domain containing protein 0.0025 0.0047 0.0096
Mycobacterium ulcerans glutamate synthase subunit beta 0.0034 0.0087 0.0096
Echinococcus multilocularis thioredoxin glutathione reductase 0.0373 0.1621 0.1615
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0027 0.0055 0.0176
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0223 0.0302
Toxoplasma gondii thioredoxin reductase 0.0368 0.1599 0.5119
Brugia malayi ImpB/MucB/SamB family protein 0.0686 0.3035 0.4559
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0358 0.0351
Trypanosoma cruzi DNA polymerase eta, putative 0.0686 0.3035 0.5322
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0159 0.0651 0.0643
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0053 0.0085
Mycobacterium ulcerans hypothetical protein 0.0034 0.0087 0.0096
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0074 0.0066
Schistosoma mansoni terminal deoxycytidyl transferase 0.0444 0.1939 0.1933
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0197 0.0365
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0934 0.4156 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0198 0.0829 0.1236
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0034 0.0087 0.0082
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0197 0.0564
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0066 0.0231 0.0347
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0023
Loa Loa (eye worm) beta-lactamase 0.0036 0.0098 0.0136
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0048 0.0149 0.0141
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0358 0.0351
Mycobacterium tuberculosis Putative ferredoxin reductase 0.084 0.3732 0.8976
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0027 0.0055 0.0047
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0168 0.0242
Echinococcus multilocularis cpg binding protein 0.0261 0.1112 0.1105
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0044 0.0088
Brugia malayi jmjC domain containing protein 0.0159 0.0651 0.0968
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0702 0.3107 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0034 0.0087 0.0079
Trichomonas vaginalis glutathione reductase, putative 0.0128 0.0511 0.0768
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0034 0.0087 0.0207
Schistosoma mansoni microtubule-associated protein tau 0.2227 1 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0034 0.0087 0.0119
Mycobacterium tuberculosis Conserved protein 0.0036 0.0098 0.0193
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0028
Echinococcus granulosus peregrin 0.0039 0.011 0.0102
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0044 0.0085
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0047 0.0083
Giardia lamblia Glutamate synthase 0.0034 0.0087 0.0105
Trypanosoma cruzi DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Echinococcus multilocularis dna polymerase kappa 0.0617 0.2722 0.2717
Trichomonas vaginalis CAMK family protein kinase 0.0511 0.2245 0.3378
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.0709 0.0702
Loa Loa (eye worm) flap endonuclease-1 0.0056 0.0186 0.0268
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0047 0.0148 0.0406
Trichomonas vaginalis chromobox protein, putative 0.0149 0.0609 0.0916
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0241 0.0233
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0027 0.0055 0.0047
Echinococcus granulosus importin subunit beta 1 0.0064 0.0225 0.0217
Trypanosoma cruzi importin beta-1 subunit, putative 0.0052 0.017 0.0298
Brugia malayi CHD4 protein 0.0035 0.0091 0.0125
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0197 0.0466
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0044 0.0141
Trichomonas vaginalis DNA helicase recq, putative 0.0028 0.0058 0.0087
Trypanosoma brucei phosphoglycerate kinase 0.0702 0.3107 0.5449
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0098 0.0193
Plasmodium falciparum glutathione reductase 0.0368 0.1599 0.5109
Schistosoma mansoni cpg binding protein 0.0261 0.1112 0.1105
Trichomonas vaginalis DNA polymerase eta, putative 0.0617 0.2722 0.4095
Mycobacterium tuberculosis Conserved hypothetical protein 0.0672 0.2972 0.714
Brugia malayi M-phase phosphoprotein, mpp8 0.0024 0.0044 0.0054
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0034 0.0087 0.0152
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0179 0.0745 0.1306
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0136
Trypanosoma cruzi ISWI complex protein 0.0019 0.002 0.0035
Leishmania major DNA polymerase kappa, putative 0.0138 0.0556 0.0975
Brugia malayi mbt repeat family protein 0.0097 0.0372 0.0549
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0094 0.0087
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0034 0.0087 0.013
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0044 0.0054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0066 0.0231 0.0347
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0702 0.3107 0.7444
Echinococcus multilocularis importin subunit beta 1 0.0064 0.0225 0.0217
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0223 0.0302
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0128 0.0511 0.1403
Schistosoma mansoni hypothetical protein 0.0026 0.0053 0.0045
Schistosoma mansoni DNA polymerase IV / kappa 0.0138 0.0556 0.0549
Echinococcus granulosus dnaJ subfamily B 0.0826 0.3668 0.3663
Trypanosoma brucei DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0044 0.0066
Schistosoma mansoni disulfide oxidoreductase 0.0034 0.0087 0.0079
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0138 0.0556 0.1745
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0198 0.0829 0.1453
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0098 0.0136
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0098 0.0193
Echinococcus granulosus lysine specific demethylase 5A 0.0105 0.0408 0.0401
Onchocerca volvulus 0.0092 0.0351 0.1529
Schistosoma mansoni hypothetical protein 0.0348 0.1507 0.1501
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0198 0.0829 0.1236
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0097 0.0372 0.1622
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0034 0.0087 0.0119
Trichomonas vaginalis rotamase, putative 0.0035 0.009 0.0136
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0198 0.0829 0.2667
Trypanosoma brucei DNA polymerase kappa, putative 0.0311 0.1339 0.2348
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0106 0.0288
Plasmodium falciparum DNA repair protein REV1, putative 0.0138 0.0556 0.1728
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0702 0.3107 0.5449
Brugia malayi hypothetical protein 0.0161 0.066 0.0982
Schistosoma mansoni glutamate synthase 0.0034 0.0087 0.0079
Echinococcus granulosus expressed protein 0.0036 0.0094 0.0086
Plasmodium falciparum flap endonuclease 1 0.0056 0.0186 0.0529
Loa Loa (eye worm) hypothetical protein 0.0161 0.066 0.0982
Schistosoma mansoni bromodomain containing protein 0.0018 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0068
Trichomonas vaginalis flap endonuclease-1, putative 0.0056 0.0186 0.028
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0702 0.3107 0.7466
Loa Loa (eye worm) hypothetical protein 0.0702 0.3107 0.4668
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0044 0.0066
Toxoplasma gondii ImpB/MucB/SamB family protein 0.038 0.1652 0.5291
Echinococcus granulosus GTP binding nuclear protein Ran 0.0047 0.0148 0.014
Echinococcus granulosus mixed lineage leukemia protein mll 0.0048 0.0149 0.0141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0128 0.0511 0.0895
Brugia malayi Flap endonuclease-1 0.0056 0.0186 0.0268
Echinococcus multilocularis zinc finger protein 0.0018 0.0017 0.0009
Giardia lamblia PHD finger protein 15 0.0031 0.0074 0.0062
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0024 0.0044 0.0088
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0047 0.006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0168 0.0242
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0098 0.0147
Schistosoma mansoni DNA polymerase eta 0.0686 0.3035 0.303
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0052 0.0092
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0034 0.0087 0.0152
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0136
Loa Loa (eye worm) heterochromatin protein 1 0.0149 0.0609 0.0905
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0044 0.0141
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0079 0.0293 0.0285
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0106 0.0098
Trypanosoma cruzi trypanothione reductase, putative 0.0368 0.1599 0.2803
Echinococcus granulosus chromobox protein 1 0.0149 0.0609 0.0601
Entamoeba histolytica disulphide oxidoreductase, putative 0.0034 0.0087 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0349 0.1511 0.2649
Plasmodium falciparum histone acetyltransferase GCN5 0.0088 0.0333 0.1007
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.006
Leishmania major modification methylase-like protein 0.004 0.0115 0.0202
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0194 0.0187
Trypanosoma brucei DNA polymerase IV, putative 0.0617 0.2722 0.4774
Toxoplasma gondii NADPH-glutathione reductase 0.0128 0.0511 0.1598
Loa Loa (eye worm) jmjC domain-containing protein 0.0105 0.0408 0.0603
Echinococcus granulosus snurportin 1 0.0689 0.3046 0.3041
Mycobacterium ulcerans dehydrogenase 0.0034 0.0087 0.0096
Onchocerca volvulus Serine\/threonine kinase homolog 0.0511 0.2245 0.9991
Trypanosoma brucei phosphoglycerate kinase 0.0258 0.1099 0.1926
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0035 0.0091 0.0083
Schistosoma mansoni alpha-glucosidase 0.0148 0.0601 0.0594
Trypanosoma brucei DNA damage repair protein, putative 0.0138 0.0556 0.0975
Brugia malayi Protein cec-1. 0.0024 0.0044 0.0054
Plasmodium vivax importin-beta 2, putative 0.0064 0.0225 0.0671
Schistosoma mansoni ran 0.0047 0.0148 0.014
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.011 0.0433 0.064
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0034 0.0087 0.0079
Brugia malayi hypothetical protein 0.0017 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0013
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0027 0.0055 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.012 0.0181
Toxoplasma gondii DNA methyltransferase 2, putative 0.004 0.0115 0.0318
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0905 0.4023 0.4019
Loa Loa (eye worm) hypothetical protein 0.0066 0.023 0.0335
Brugia malayi F/Y-rich N-terminus family protein 0.0068 0.0241 0.0352
Trypanosoma cruzi DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Loa Loa (eye worm) hypothetical protein 0.0097 0.0372 0.0549
Brugia malayi CXXC zinc finger family protein 0.025 0.1065 0.1592
Trichomonas vaginalis esterase, putative 0.0036 0.0098 0.0147
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0034 0.0087 0.0105
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0197 0.0432
Echinococcus granulosus SAM and MBT domain containing protein 0.0097 0.0372 0.0365
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.011 0.0433 0.0425
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0128 0.0511 0.0895
Leishmania major DNA polymerase eta, putative 0.0686 0.3035 0.5322
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.084 0.3732 0.8976
Schistosoma mansoni jumonji/arid domain-containing protein 0.0105 0.0408 0.0401
Schistosoma mansoni jumonji domain containing protein 0.0138 0.0556 0.0549
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0179 0.0745 0.1306
Echinococcus granulosus phosphoglycerate kinase 1 0.0702 0.3107 0.3102
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0934 0.4156 1
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0047 0.004
Trypanosoma brucei unspecified product 0.0574 0.2528 0.4433
Loa Loa (eye worm) RecQ helicase 0.0028 0.0058 0.0076
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0128 0.0511 0.119
Trichomonas vaginalis importin beta-1, putative 0.0052 0.017 0.0255
Leishmania major phosphoglycerate kinase B, cytosolic 0.0702 0.3107 0.5449
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0511 0.2245 0.337
Echinococcus granulosus geminin 0.0348 0.1507 0.1501
Echinococcus granulosus chromobox protein 2 0.0024 0.0044 0.0036
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0034 0.0087 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0358 0.0351
Brugia malayi Pre-SET motif family protein 0.0068 0.0241 0.0351
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0044 0.0088
Trypanosoma brucei DNA polymerase IV, putative 0.0617 0.2722 0.4774
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0128 0.0511 0.0895
Leishmania major DNA damage repair protein, putative 0.0138 0.0556 0.0975
Plasmodium falciparum heterochromatin protein 1 0.0024 0.0044 0.0069
Loa Loa (eye worm) hypothetical protein 0.0034 0.0087 0.0119
Echinococcus multilocularis dnaJ subfamily B 0.0826 0.3668 0.3663
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.009 0.0238
Schistosoma mansoni sulfide quinone reductase 0.0034 0.0087 0.0079
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0604 0.2664 0.4671
Echinococcus granulosus chromobox protein 1 0.0149 0.0609 0.0601
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0027 0.0055 0.012
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0225 0.0394
Trypanosoma cruzi DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0047 0.004
Schistosoma mansoni bromodomain containing protein 0.0018 0.0017 0.0009
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0034 0.0087 0.0079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0128 0.0511 0.0895
Schistosoma mansoni kinase 0.026 0.1108 0.1102
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.0709 0.1057
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0106 0.0159
Echinococcus granulosus polycomb protein SCMH1 0.0097 0.0372 0.0365
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0223 0.0324
Schistosoma mansoni polybromo-1 0.0017 0.0011 0.0003
Echinococcus multilocularis chromobox protein 1 0.0149 0.0609 0.0601
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0225 0.0394
Echinococcus multilocularis polybromo 1 0.0017 0.0011 0.0003
Plasmodium vivax heterochromatin protein 1, putative 0.0024 0.0044 0.0085
Schistosoma mansoni hypothetical protein 0.0034 0.0087 0.0079
Brugia malayi RNA, U transporter 1 0.0183 0.0763 0.1137
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0223 0.0495
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.013
Schistosoma mansoni chromobox protein 0.0024 0.0044 0.0036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0098 0.009
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0027 0.0055 0.0071
Entamoeba histolytica thioredoxin reductase, putative 0.0034 0.0087 0.0279
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0128 0.0511 0.1581
Trichomonas vaginalis ran, putative 0.0047 0.0148 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0617 0.2722 0.4774
Trichomonas vaginalis chromobox protein, putative 0.009 0.0341 0.0513
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0053 0.0085
Echinococcus multilocularis flap endonuclease 1 0.0056 0.0186 0.0178
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0128 0.0511 0.1595
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0604 0.2664 0.4671
Plasmodium vivax glutathione reductase, putative 0.0368 0.1599 0.5117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0358 0.0351
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0047 0.004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.0241 0.0233
Entamoeba histolytica hypothetical protein 0.0024 0.0044 0.0141
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0048 0.0149 0.0141
Echinococcus granulosus polybromo 1 0.0017 0.0011 0.0003
Toxoplasma gondii ABC1 family protein 0.0036 0.0098 0.0263
Brugia malayi beta-lactamase family protein 0.0036 0.0098 0.0136
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0034 0.0087 0.0096
Mycobacterium tuberculosis Probable oxidoreductase 0.0934 0.4156 1
Brugia malayi Importin beta-1 subunit 0.0064 0.0225 0.0327
Brugia malayi PHD-finger family protein 0.0018 0.0017 0.0013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.017 0.0255
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0047 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0044 0.0066
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0053 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0094 0.0141
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0034 0.0087 0.0079
Mycobacterium ulcerans NADH dehydrogenase 0.0034 0.0087 0.0096
Schistosoma mansoni hypothetical protein 0.0826 0.3668 0.3663
Trypanosoma cruzi NADH dehydrogenase, putative 0.0034 0.0087 0.0152
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0098 0.0193
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0368 0.1599 0.382
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0047 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0144 0.0217
Trichomonas vaginalis chromobox protein, putative 0.009 0.0341 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0044 0.0066
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0034 0.0087 0.0096
Giardia lamblia Histone acetyltransferase GCN5 0.0088 0.0333 0.0913
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0018 0.0017 0.0009
Schistosoma mansoni sulfide quinone reductase 0.0034 0.0087 0.0079
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.004 0.0115 0.0318
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0098 0.0147
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0034 0.0087 0.0096
Schistosoma mansoni alpha glucosidase 0.0038 0.0106 0.0098
Brugia malayi hypothetical protein 0.0024 0.0044 0.0054
Mycobacterium ulcerans DNA polymerase IV 0.0617 0.2722 0.4075
Loa Loa (eye worm) helicase 0.0024 0.0044 0.0054
Brugia malayi Disco-interacting protein 2 homolog 0.0078 0.0288 0.0422
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0106 0.0185
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0358 0.0528
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0094 0.0087
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0702 0.3107 1
Schistosoma mansoni rotamase 0.0036 0.0094 0.0086
Loa Loa (eye worm) mbt repeat family protein 0.0097 0.0372 0.0549
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.0312 0.1353
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0047 0.0083
Trichomonas vaginalis dullard protein, putative 0.0027 0.0055 0.0082
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0223 0.0666
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0034 0.0087 0.0226
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0604 0.2664 0.4671
Echinococcus granulosus dna polymerase kappa 0.0617 0.2722 0.2717
Schistosoma mansoni myelin transcription factor 1 myt1 0.011 0.0433 0.0425
Trypanosoma brucei phosphoglycerate kinase, putative 0.0258 0.1099 0.1926
Schistosoma mansoni hypothetical protein 0.0031 0.0074 0.0066
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0054
Plasmodium vivax phosphoglycerate kinase, putative 0.0702 0.3107 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0047 0.004
Onchocerca volvulus 0.0034 0.0087 0.0347
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0059 0.0199 0.0191
Echinococcus granulosus histone acetyltransferase KAT2B 0.0319 0.1375 0.1369
Echinococcus multilocularis disco interacting protein 2 0.0079 0.0293 0.0285
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0556 0.0975
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0023
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0034 0.0087 0.013
Echinococcus granulosus histone acetyltransferase KAT2B 0.0097 0.037 0.0362
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0098 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0098 0.026
Echinococcus multilocularis bloom syndrome protein 0.0028 0.0058 0.005
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0034 0.0087 0.0096
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0702 0.3107 0.4674
Brugia malayi Heterochromatin protein 1 0.0149 0.0609 0.0905
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.009 0.029
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0074 0.0066
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0258 0.1099 0.1926
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0106 0.0159
Schistosoma mansoni ap endonuclease 0.0058 0.0197 0.0189
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0128 0.0511 0.0503
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0053 0.0046
Schistosoma mansoni flap endonuclease-1 0.005 0.0162 0.0154
Onchocerca volvulus 0.0026 0.0053 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0044 0.0066
Echinococcus multilocularis 0.0027 0.0055 0.0047
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0394 0.1715 0.1709
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0034 0.0087 0.0079
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0048 0.0149 0.0141
Trichomonas vaginalis chromobox protein, putative 0.0149 0.0609 0.0916
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0047 0.004
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.004 0.0115 0.037
Brugia malayi PHD-finger family protein 0.0021 0.0026 0.0028
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0034 0.0087 0.0166
Trichomonas vaginalis CAMK family protein kinase 0.0253 0.1078 0.1621
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0053 0.0068
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0197 0.0285
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0044 0.0069
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0128 0.0511 0.1595
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0034 0.0087 0.0152
Echinococcus granulosus flap endonuclease 1 0.0056 0.0186 0.0178
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0034 0.0087 0.0079
Brugia malayi glutamate synthase 0.0034 0.0087 0.0119
Echinococcus granulosus Chromobox protein 3 0.0024 0.0044 0.0036
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.045 0.1969 0.2953
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0034 0.0087 0.0279
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0197 0.0345
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0128 0.0511 0.0895
Brugia malayi SET domain containing protein 0.0031 0.0073 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0511 0.2245 0.3378
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0136
Trichomonas vaginalis glutaminase, putative 0.1485 0.6648 1
Brugia malayi Phosphoglycerate kinase 0.0702 0.3107 0.4668
Schistosoma mansoni zinc finger protein 0.0018 0.0017 0.0009
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0034 0.0087 0.0152
Onchocerca volvulus 0.0512 0.2248 1
Brugia malayi SET domain containing protein 0.0026 0.005 0.0063
Mycobacterium ulcerans glutaminase 0.1485 0.6648 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0034 0.0087 0.013
Schistosoma mansoni sex comb on midleg homolog 0.0097 0.0372 0.0365
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0034 0.0087 0.0166
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.004 0.0115 0.0299
Entamoeba histolytica deoxycytidyl transferase, putative 0.0444 0.1939 0.624
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0044 0.0066
Onchocerca volvulus 0.0036 0.0098 0.0397
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0128 0.0511 0.0895
Trypanosoma brucei DNA polymerase IV, putative 0.0574 0.2528 0.4433
Brugia malayi jmjC domain containing protein 0.0025 0.0047 0.006
Echinococcus multilocularis Chromo domain 0.0024 0.0044 0.0036
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0328 0.1417 0.141
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0207 0.0871 0.385
Loa Loa (eye worm) hypothetical protein 0.0311 0.1339 0.2005
Brugia malayi Pre-SET motif family protein 0.045 0.1969 0.2953
Entamoeba histolytica Ran family GTPase 0.0047 0.0148 0.0476
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0044 0.0066
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.0984 0.2335
Schistosoma mansoni hypothetical protein 0.0689 0.3046 0.3041
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0044 0.0141
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0106 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0312 0.0469
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0098 0.0147
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0106 0.0185
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.009 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0201 0.0303
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0148 0.026
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0223 0.0215
Toxoplasma gondii histone lysine methyltransferase SET1 0.0356 0.1541 0.4931
Schistosoma mansoni glutaminase 0.1485 0.6648 0.6645
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0074 0.0184
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0197 0.0296
Entamoeba histolytica serine/threonine protein kinase, putative 0.0511 0.2245 0.7226
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0047 0.008
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.084 0.3732 0.8976
Schistosoma mansoni phosphoglycerate kinase 0.0702 0.3107 0.3102
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0128 0.0511 0.0895
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0128 0.0511 0.0736
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0052 0.0092
Echinococcus multilocularis microtubule associated protein 2 0.2227 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0128 0.0511 0.0895
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0034 0.0087 0.0079
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.017 0.0255
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0197 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.012 0.0181
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0258 0.1099 0.1926
Schistosoma mansoni myst-related protein 0.0021 0.0031 0.0023
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0444 0.1939 0.1933
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0053 0.0093
Echinococcus granulosus CTD small phosphatase protein like 0.0027 0.0055 0.0047
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0106 0.0159
Onchocerca volvulus 0.0161 0.066 0.2908
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0066 0.0231 0.0347
Echinococcus granulosus Chromo domain 0.0024 0.0044 0.0036
Brugia malayi glutathione reductase 0.0368 0.1599 0.2396
Echinococcus multilocularis peregrin 0.0039 0.011 0.0102
Loa Loa (eye worm) hypothetical protein 0.0031 0.0074 0.0099
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0709 0.0702
Chlamydia trachomatis thioredoxin reductase 0.0034 0.0087 0.0207
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0004
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0258 0.1099 0.1926
Schistosoma mansoni phosphoglycerate kinase 0.0702 0.3107 0.3102
Schistosoma mansoni alpha-glucosidase 0.0148 0.0601 0.0594
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0106 0.0159
Echinococcus multilocularis transcription factor Dp 1 0.0115 0.0452 0.0444
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0223 0.0302
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0059 0.0199 0.0191
Leishmania major hypothetical protein, conserved 0.0025 0.0047 0.0083
Trypanosoma brucei hypothetical protein, conserved 0.0138 0.0556 0.0975
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0128 0.0511 0.0757
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0055 0.0082
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1276 0.5703 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0056 0.0186 0.0326
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0034 0.0087 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.012 0.0181
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0068
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0197 0.0296
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0136
Trichomonas vaginalis dullard protein, putative 0.0027 0.0055 0.0082
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0487 0.2133 0.5112
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0068 0.0241 0.0233
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0223 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.012 0.0181
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0106 0.0159
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0034 0.0087 0.013
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0034 0.0087 0.0223
Leishmania major hypothetical protein, conserved 0.0034 0.0087 0.0152
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0034 0.0087 0.0226
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0098 0.0109
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0098 0.0193
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0053 0.0171
Schistosoma mansoni glutamate synthase 0.0034 0.0087 0.0079
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0034 0.0087 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.012 0.0181
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0092 0.0351 0.0344
Leishmania major importin beta-1 subunit, putative 0.0052 0.017 0.0298
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0087 0.0152
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0198 0.0829 0.0822
Brugia malayi jmjC domain containing protein 0.0025 0.0047 0.006
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0055 0.0082
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0044 0.0066
Mycobacterium ulcerans hypothetical protein 0.0138 0.0556 0.0805
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0027 0.0055 0.0123
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0047 0.0148 0.0211
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0094 0.013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0053 0.0046
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0128 0.0511 0.0736
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0035 0.0091 0.0083
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0053 0.0046
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0098 0.0172
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0074 0.0184
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0128 0.0266
Echinococcus multilocularis histone acetyltransferase MYST2 0.011 0.0433 0.0425
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0197 0.0345
Leishmania major phosphoglycerate kinase C, glycosomal 0.0702 0.3107 0.5449
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0034 0.0087 0.0226
Schistosoma mansoni ran 0.0047 0.0148 0.014
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0044 0.0066
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0258 0.1099 0.1926
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0047 0.0148 0.026
Plasmodium falciparum glutathione reductase 0.0128 0.0511 0.1581
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.0241 0.0233
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0044 0.0036
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0128 0.0511 0.0895

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.