Detailed information for compound 809829

Basic information

Technical information
  • TDR Targets ID: 809829
  • Name: (3Z)-5-phenyl-3-(thiophen-2-ylmethylidene)fur an-2-one
  • MW: 254.304 | Formula: C15H10O2S
  • H donors: 0 H acceptors: 1 LogP: 3.7 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OC(=C/C/1=C/c1cccs1)c1ccccc1
  • InChi: 1S/C15H10O2S/c16-15-12(9-13-7-4-8-18-13)10-14(17-15)11-5-2-1-3-6-11/h1-10H/b12-9-
  • InChiKey: DHSHIGJDJUERHQ-XFXZXTDPSA-N  


Substructure search Similarity search

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Synonyms

  • (3Z)-5-phenyl-3-(2-thienylmethylene)furan-2-one
  • (3Z)-5-phenyl-3-(2-thienylmethylene)-2-furanone
  • BAS 00849062
  • BIM-0008912.P001
  • MLS000566983
  • SMR000176167
  • ZINC00281749
  • 5-Phenyl-3-thiophen-2-ylmethylene-3H-furan-2-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.005 0.0438 0.1452
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0016 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.022 0.0716
Schistosoma mansoni zinc finger protein 0.0025 0.0186 0.0186
Plasmodium vivax multidomain scavenger receptor, putative 0.0178 0.172 1
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0453 0.0453
Echinococcus granulosus zinc finger protein 0.0025 0.0186 0.017
Loa Loa (eye worm) hypothetical protein 0.0178 0.172 0.5709
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0033 0.0033
Mycobacterium ulcerans ATPase 0.0054 0.0476 0.1533
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0033 0.0071
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0033 0.0071
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.022 0.0679
Schistosoma mansoni laminin gamma-3 chain 0.0009 0.0017 0.0017
Echinococcus multilocularis neural cadherin 0.0009 0.0017 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0135 0.0434
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0674 0.0659
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0052 0.0453 0.0438
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0034 0.0018
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0021 0.0146 0.0465
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Echinococcus granulosus Diacylglycerol kinase zeta 0.0012 0.0052 0.0035
Mycobacterium tuberculosis Conserved protein 0.0306 0.3014 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8321 0.8318
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0033 0.0111
Entamoeba histolytica cdc48-like protein, putative 0.0086 0.0794 0.2594
Echinococcus granulosus serine:threonine protein kinase mig 15 0.017 0.1643 0.1629
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0086 0.0794 0.4563
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0171
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.022 0.0679
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0033 0.0033
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0052 0.0456
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0135 0.0434
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.0021 0.0146 0.0465
Leishmania major diacylglycerol kinase-like protein 0.0012 0.0052 0.0456
Brugia malayi Temporarily assigned gene name protein 59 0.005 0.0438 0.1719
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0197 0.0652
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.022 0.0679
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0016 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0033 0.0017
Plasmodium falciparum diacylglycerol kinase, putative 0.0012 0.0052 0.0208
Trichomonas vaginalis spermatogenesis associated factor, putative 0.009 0.0841 0.2943
Brugia malayi Cadherin domain containing protein 0.0009 0.0017 0.0004
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0139 0.0123
Onchocerca volvulus 0.0009 0.0017 0.0004
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0161 0.1549 0.1536
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0052 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0111
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0171
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.009 0.0841 0.0826
Trichomonas vaginalis bmru protein, putative 0.0012 0.0052 0.0126
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0033 0.0033
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0052 0.0456
Brugia malayi EGF-like domain containing protein 0.0009 0.0017 0.0004
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0197 0.0736
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0012 0.0052 0.0171
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0017 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0135 0.0434
Schistosoma mansoni cell division control protein 48 aaa family protein 0.009 0.0841 0.0841
Loa Loa (eye worm) vesicle-fusing ATPase 0.0053 0.0465 0.1542
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.005 0.0438 0.0422
Toxoplasma gondii cell division protein CDC48CY 0.009 0.0841 1
Onchocerca volvulus 0.0178 0.172 0.6084
Loa Loa (eye worm) hypothetical protein 0.0053 0.0466 0.1548
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0181 0.1758 0.1745
Brugia malayi Pre-SET motif family protein 0.0252 0.2468 1
Echinococcus granulosus cpg binding protein 0.0033 0.0261 0.0245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0033 0.0111
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0197 0.0736
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0301 0.0301
Onchocerca volvulus Neurogenic locus notch homolog 0.0009 0.0017 0.0004
Loa Loa (eye worm) hypothetical protein 0.0306 0.3014 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0016 0.0039
Schistosoma mansoni hypothetical protein 0.0025 0.0182 0.0182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0033 0.0017
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0301 0.3452
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0016 0.0039
Onchocerca volvulus 0.0029 0.0221 0.0732
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0052 0.0453 0.0438
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0222 0.0206
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0012 0.0052 0.0052
Plasmodium falciparum diacylglycerol kinase, putative 0.0012 0.0052 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0033 0.0071
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0016 0.0039
Schistosoma mansoni hypothetical protein 0.041 0.4056 0.4056
Echinococcus granulosus notch 0.0009 0.0017 0.0001
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0057 0.0165
Brugia malayi AMP-binding enzyme family protein 0.0029 0.022 0.083
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0033 0.0071
Schistosoma mansoni thyroid hormone receptor 0.001 0.0033 0.0033
Echinococcus granulosus FTZ F1 alpha 0.001 0.0033 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0111
Brugia malayi Eye-specific diacylglycerol kinase 0.0012 0.0052 0.0144
Brugia malayi hypothetical protein 0.0026 0.0197 0.0736
Onchocerca volvulus 0.0026 0.0197 0.0644
Brugia malayi nuclear hormone receptor 0.001 0.0033 0.0071
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0197 0.0644
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0052 0.0118
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Brugia malayi vesicle-fusing ATPase 0.0053 0.0465 0.1829
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0161 0.1549 0.1536
Schistosoma mansoni sphingosine kinase A B 0.0306 0.3014 0.3014
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0368 0.0353
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0033 0.0017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0033 0.0017
Brugia malayi EGF-like domain containing protein 0.0009 0.0017 0.0004
Echinococcus multilocularis neurogenic locus protein delta 0.0009 0.0017 0.0001
Schistosoma mansoni rab6-interacting 0.0178 0.172 0.172
Brugia malayi Diacylglycerol kinase protein 2 0.0012 0.0052 0.0144
Loa Loa (eye worm) hypothetical protein 0.0049 0.0427 0.1416
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0054 0.0476 0.5572
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0033 0.0071
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0017 0.0017
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0086 0.0794 0.2594
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0052 0.0118
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0147 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0033 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Brugia malayi hypothetical protein 0.0178 0.172 0.6951
Echinococcus granulosus RUN 0.0178 0.172 0.1707
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0052 0.0456
Brugia malayi Calcium binding EGF domain containing protein 0.0009 0.0017 0.0004
Loa Loa (eye worm) hypothetical protein 0.0046 0.0398 0.132
Echinococcus multilocularis lipoxygenase domain containing protein 0.0178 0.172 0.1707
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0053
Echinococcus multilocularis neurogenic locus protein delta 0.0009 0.0017 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.1758 0.1758
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0052 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0052 0.0456
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0111
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0197 0.0736
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0052 0.0052
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0016 0.0039
Schistosoma mansoni hypothetical protein 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0111
Trypanosoma brucei ISWI complex protein 0.0018 0.0117 0.1303
Schistosoma mansoni hypothetical protein 0.0009 0.0017 0.0017
Schistosoma mansoni notch 0.0009 0.0017 0.0017
Echinococcus granulosus delta-like protein 1 0.0009 0.0017 0.0001
Schistosoma mansoni sphingoid long chain base kinase 0.0306 0.3014 0.3014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0197 0.0652
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0053
Schistosoma mansoni notch 0.0009 0.0017 0.0017
Echinococcus granulosus Diacylglycerol kinase theta 0.0012 0.0052 0.0035
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0052 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0033 0.0071
Brugia malayi CXXC zinc finger family protein 0.0029 0.0221 0.0836
Brugia malayi follicle stimulating hormone receptor 0.0232 0.2267 0.918
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.022 0.0679
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0052 0.0453 0.0438
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.022 0.2618
Schistosoma mansoni zinc finger protein 0.0018 0.0117 0.0117
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0147 0.0767
Echinococcus multilocularis fibropellin Ia 0.0009 0.0017 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0052 0.0126
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.005 0.0438 0.0438
Schistosoma mansoni nuclear hormone receptor 0.001 0.0033 0.0033
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0052 0.0126
Schistosoma mansoni septate junction protein 0.0009 0.0017 0.0017
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0147 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0197 0.0652
Schistosoma mansoni lipoxygenase 0.1 1 1
Mycobacterium tuberculosis Diacylglycerol kinase 0.0012 0.0052 0.0157
Schistosoma mansoni rab6-interacting 0.0178 0.172 0.172
Brugia malayi EGF-like domain containing protein 0.0009 0.0017 0.0004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0033 0.0017
Onchocerca volvulus 0.0009 0.0017 0.0004
Mycobacterium ulcerans hypothetical protein 0.0306 0.3014 1
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.005 0.0438 0.542
Echinococcus granulosus neurogenic locus notch protein 4 0.0009 0.0017 0.0001
Echinococcus granulosus dnaJ subfamily B 0.041 0.4056 0.4046
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0009 0.0017 0.0004
Leishmania major hypothetical protein, conserved 0.0018 0.0117 0.1303
Onchocerca volvulus 0.0009 0.0017 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0033 0.0033
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0281 0.0265
Onchocerca volvulus 0.0026 0.0197 0.0644
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0139 0.0123
Echinococcus multilocularis cpg binding protein 0.0033 0.0261 0.0245
Loa Loa (eye worm) ceramide kinase 0.0012 0.0052 0.0171
Echinococcus granulosus protein jagged 2 0.0009 0.0017 0.0001
Brugia malayi GCC2 and GCC3 family protein 0.0009 0.0017 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0111
Brugia malayi AMP-binding enzyme family protein 0.0029 0.022 0.083
Schistosoma mansoni notch 0.0009 0.0017 0.0017
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8321 0.8321
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0161 0.1549 0.6254
Brugia malayi diacylglycerol kinase 0.0012 0.0052 0.0144
Loa Loa (eye worm) hypothetical protein 0.005 0.0438 0.1452
Brugia malayi Delta serrate ligand family protein 0.0009 0.0017 0.0004
Echinococcus granulosus neurogenic locus notch protein 0.0009 0.0017 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0033 0.0017
Brugia malayi Pre-SET motif family protein 0.0037 0.0301 0.1161
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.2267 0.7522
Echinococcus multilocularis protein jagged 1 0.0009 0.0017 0.0001
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0017 0.0001
Trypanosoma cruzi ISWI complex protein 0.0018 0.0117 0.1303
Schistosoma mansoni rap gtpase-activating protein 0.005 0.0438 0.0438
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0052 0.0456
Schistosoma mansoni bromodomain containing protein 0.0078 0.0717 0.0717
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.1549 0.1549
Schistosoma mansoni polycystin 1-related 0.0178 0.172 0.172
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Schistosoma mansoni loxhd1 0.0178 0.172 0.172
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0197 0.0644
Onchocerca volvulus 0.0012 0.0052 0.0126
Onchocerca volvulus Putative cubilin 0.0009 0.0017 0.0004
Schistosoma mansoni notch 0.0009 0.0017 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0033 0.0111
Loa Loa (eye worm) hypothetical protein 0.0178 0.172 0.5709
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0052 0.0453 0.1503
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0147 0.0474
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0012 0.0052 0.043
Brugia malayi hypothetical protein 0.0012 0.0052 0.0144
Echinococcus multilocularis zinc finger protein 0.0025 0.0186 0.017
Onchocerca volvulus 0.001 0.0033 0.0062
Schistosoma mansoni hypothetical protein 0.0009 0.0017 0.0017
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0033 0.0033
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0182 0.0605
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.009 0.0841 0.0826
Onchocerca volvulus 0.0009 0.0017 0.0004
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.022 0.0716
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0453 0.0453
Toxoplasma gondii EGF family domain-containing protein 0.0009 0.0017 0.0012
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.0453 0.0438
Loa Loa (eye worm) hypothetical protein 0.0021 0.0147 0.0487
Echinococcus granulosus sphingosine kinase 1 0.0306 0.3014 0.3002
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0033 0.0111
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0016 0.0053
Brugia malayi Doublecortin family protein 0.0178 0.172 0.6951
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0033 0.0017
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0016 0.0039
Onchocerca volvulus Peroxidase homolog 0.0026 0.0197 0.0644
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0012 0.0052 0.0035
Loa Loa (eye worm) notch protein 0.0009 0.0017 0.0057
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0033 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Schistosoma mansoni notch 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0016 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0033 0.0071
Echinococcus granulosus neurogenic locus notch protein 0.0009 0.0017 0.0001
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0197 0.0644
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.022 0.2618
Brugia malayi ecdysteroid receptor 0.001 0.0033 0.0071
Schistosoma mansoni peroxidasin 0.0026 0.0197 0.0197
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0033 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0033 0.0071
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0016 0.0039
Echinococcus granulosus lipoxygenase domain containing protein 0.0178 0.172 0.1707
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Brugia malayi valosin containing protein 0.0053 0.0465 0.1829
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0508 0.0493
Loa Loa (eye worm) hypothetical protein 0.0029 0.022 0.0729
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0111
Loa Loa (eye worm) diacylglycerol kinase 2 0.0012 0.0052 0.0171
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0052 0.0453 0.0438
Loa Loa (eye worm) Notch2 0.0009 0.0017 0.0057
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.005 0.0438 0.0422
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.0453 0.0438
Plasmodium vivax diacylglycerol kinase, putative 0.0012 0.0052 0.0208
Schistosoma mansoni notch 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0147 0.0487
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Echinococcus multilocularis RUN 0.0178 0.172 0.1707
Brugia malayi hypothetical protein 0.0178 0.172 0.6951
Schistosoma mansoni hypothetical protein 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0147 0.0487
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.022 1
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0012 0.0052 0.0126
Giardia lamblia AAA family ATPase 0.0054 0.0476 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0033 0.0033
Leishmania major diacylglycerol kinase, putative 0.0012 0.0052 0.0456
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0033 0.0111
Echinococcus granulosus lipoxygenase domain containing protein 0.0178 0.172 0.1707
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0135 0.0434
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0086 0.0794 0.4563
Echinococcus multilocularis neurogenic locus notch protein 0.0009 0.0017 0.0001
Echinococcus granulosus slit 2 protein 0.0009 0.0017 0.0001
Brugia malayi EGF-like domain containing protein 0.0009 0.0017 0.0004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0033 0.0033
Echinococcus multilocularis notch 0.0009 0.0017 0.0001
Brugia malayi Bromodomain containing protein 0.0046 0.0397 0.1554
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0033 0.0071
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0121 0.1152 0.3823
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0033 0.0111
Toxoplasma gondii diacylglycerol kinase, putative 0.0012 0.0052 0.043
Loa Loa (eye worm) doublecortin family protein 0.0178 0.172 0.5709
Onchocerca volvulus 0.0009 0.0017 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0111
Mycobacterium tuberculosis Putative conserved ATPase 0.0054 0.0476 0.1566
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0052 0.0456
Echinococcus multilocularis slit 2 protein 0.0009 0.0017 0.0001
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0033 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0033 0.0071
Loa Loa (eye worm) hypothetical protein 0.0057 0.0508 0.1686
Schistosoma mansoni lipoxygenase 0.068 0.678 0.678
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0161 0.1549 0.5141
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0037 0.0307 0.0292
Echinococcus multilocularis fat cadherin tumor suppressor 0.0009 0.0017 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Brugia malayi PHD-finger family protein 0.0032 0.0251 0.0957
Echinococcus multilocularis protein jagged 2 0.0009 0.0017 0.0001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0222 0.0206
Schistosoma mansoni protein kinase 0.0121 0.1152 0.1152
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0009 0.0017 0.0004
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0197 0.0644
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0086 0.0794 0.0794
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0197 0.0652
Loa Loa (eye worm) hypothetical protein 0.0053 0.0465 0.1542
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0052 0.0456
Loa Loa (eye worm) histone methyltransferase 0.001 0.0034 0.0114
Echinococcus multilocularis protein jagged 1 0.0009 0.0017 0.0001
Echinococcus granulosus protein jagged 1 0.0009 0.0017 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Brugia malayi Protein kinase domain containing protein 0.0052 0.0453 0.1782
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0052 0.0456
Schistosoma mansoni cpg binding protein 0.0033 0.0261 0.0261
Schistosoma mansoni cell polarity protein 0.0009 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0033 0.0071
Schistosoma mansoni coup transcription factor 0.001 0.0033 0.0033
Brugia malayi Muscle positioning protein 4 0.0009 0.0017 0.0004
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0171
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0052 0.0118
Brugia malayi diacylglycerol kinase 0.0012 0.0052 0.0144
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0146 0.0485
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.022 0.0679
Trichomonas vaginalis bmru protein, putative 0.0012 0.0052 0.0126
Schistosoma mansoni hypothetical protein 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0029 0.022 0.0729
Brugia malayi Protein kinase domain containing protein 0.0161 0.1549 0.6254
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0016 0.0053
Plasmodium vivax SET domain protein, putative 0.0037 0.0301 0.167
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0033 0.0017
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0052 0.0456
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.1 1 1
Schistosoma mansoni cpg binding protein 0.0033 0.0261 0.0261
Leishmania major hypothetical protein, conserved 0.0012 0.0052 0.0456
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0222 0.0222
Brugia malayi notch-like transmembrane receptor 0.0009 0.0017 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0033 0.0071
Echinococcus granulosus fibropellin Ia 0.0009 0.0017 0.0001
Brugia malayi Blistered cuticle protein 3 0.0026 0.0197 0.0736
Onchocerca volvulus 0.0287 0.2817 1
Onchocerca volvulus 0.0029 0.022 0.0727
Brugia malayi EGF-like domain containing protein 0.0009 0.0017 0.0004
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0033 0.0017
Trypanosoma brucei Sphingosine kinase 0.0012 0.0052 0.0456
Entamoeba histolytica hypothetical protein, conserved 0.0306 0.3014 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0368 0.0353
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.022 1
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0016 0.0016
Trypanosoma brucei diacylglycerol kinase, putative 0.0012 0.0052 0.0456
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0508 0.0493
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0033 0.0017
Echinococcus multilocularis peroxidasin 0.0026 0.0197 0.0181
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0033 0.0017
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0197 0.0736
Trichomonas vaginalis set domain proteins, putative 0.0287 0.2817 1
Brugia malayi steroid hormone receptor 0.001 0.0033 0.0071
Echinococcus multilocularis neurogenic locus notch protein 4 0.0009 0.0017 0.0001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0674 0.0659
Echinococcus granulosus protein jagged 2 0.0009 0.0017 0.0001
Echinococcus multilocularis dnaJ subfamily B 0.041 0.4056 0.4046
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0052 0.0126
Brugia malayi EGF-like domain containing protein 0.0009 0.0017 0.0004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.022 0.0679
Mycobacterium ulcerans hypothetical protein 0.0029 0.022 0.0679
Echinococcus granulosus Vam6:Vps39 protein 0.005 0.0438 0.0422
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0033 0.0071
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.005 0.0438 0.0438
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0052 0.0456
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0012 0.0052 0.043
Onchocerca volvulus 0.0026 0.0197 0.0644
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0037 0.0307 0.1188
Brugia malayi nuclear receptor NHR-88 0.001 0.0033 0.0071
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0016 0.0039
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2468 0.8189
Loa Loa (eye worm) hypothetical protein 0.0085 0.0791 0.2625
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0559 0.0559
Mycobacterium ulcerans diacylglycerol kinase 0.0012 0.0052 0.0118
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0301 0.0285
Brugia malayi Peroxidasin 0.0026 0.0197 0.0736
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Echinococcus granulosus protein kinase 0.0121 0.1152 0.1138
Brugia malayi Calcium binding EGF domain containing protein 0.0009 0.0017 0.0004
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0181 0.1758 0.1745
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0301 0.0301
Schistosoma mansoni protein kinase 0.0172 0.1658 0.1658
Schistosoma mansoni vam6/vps39 related 0.005 0.0438 0.0438
Brugia malayi probable protein kinase 0.0172 0.1658 0.6698
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0012 0.0052 0.0035
Onchocerca volvulus Slit protein homolog 0.0009 0.0017 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0033 0.0017
Loa Loa (eye worm) hypothetical protein 0.017 0.1643 0.5451
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.005 0.0438 0.542
Echinococcus granulosus protein jagged 1 0.0009 0.0017 0.0001
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0033 0.0017
Brugia malayi hypothetical protein 0.005 0.0438 0.1719
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0161 0.1549 0.5474
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0147 0.0767
Echinococcus multilocularis ceramide kinase 0.0012 0.0052 0.0035
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8321 0.8318
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0033 0.0071
Echinococcus multilocularis neurogenic locus notch protein 0.0009 0.0017 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0033 0.0017
Brugia malayi Cadherin domain containing protein 0.0009 0.0017 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0017 0.0001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0221 0.0734
Echinococcus multilocularis Polycystic kidney disease protein 0.0178 0.172 0.1707
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0161 0.1549 0.5141
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0016 0.0039
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0012 0.0052 0.0052
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.022 0.2618
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0086 0.0794 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0033 0.0062
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0037 0.0307 0.0307
Brugia malayi AMP-binding enzyme family protein 0.0029 0.022 0.083
Onchocerca volvulus 0.005 0.0438 0.1504
Brugia malayi Ceramide kinase 0.0012 0.0052 0.0144
Trypanosoma brucei Valosin-containing protein 0.0086 0.0794 1
Schistosoma mansoni peroxidasin 0.0026 0.0197 0.0197
Echinococcus granulosus Polycystic kidney disease protein 0.0178 0.172 0.1707
Leishmania major sphingosine kinase A, B, putative 0.0012 0.0052 0.0456
Echinococcus granulosus neural cadherin 0.0009 0.0017 0.0001
Onchocerca volvulus 0.0178 0.172 0.6084
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0139 0.0139
Onchocerca volvulus Ceramide kinase 1 homolog 0.0012 0.0052 0.0126
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0009 0.0017 0.0017
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0012 0.0052 0.0035
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.022 0.0679
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.022 0.0679
Brugia malayi map kinase activated protein kinase protein 2 0.0181 0.1758 0.7105
Trypanosoma cruzi Valosin-containing protein, putative 0.0086 0.0794 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0438 0.1452
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0197 0.0736
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.005 0.0438 0.542
Loa Loa (eye worm) hypothetical protein 0.0021 0.0147 0.0487
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0522 0.614
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0033 0.0062
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0052 0.0126
Onchocerca volvulus 0.0037 0.0301 0.1016
Loa Loa (eye worm) hypothetical protein 0.0029 0.022 0.0729
Schistosoma mansoni hypothetical protein 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0034 0.0018
Schistosoma mansoni hypothetical protein 0.005 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0033 0.0017
Toxoplasma gondii cell division protein CDC48AP 0.0054 0.0476 0.5573
Schistosoma mansoni thyroid hormone receptor 0.001 0.0033 0.0033
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0033 0.0033
Echinococcus granulosus ceramide kinase 0.0012 0.0052 0.0035
Schistosoma mansoni hypothetical protein 0.0018 0.0117 0.0117
Leishmania major hypothetical protein, conserved 0.0012 0.0052 0.0456
Brugia malayi Calcium binding EGF domain containing protein 0.0009 0.0017 0.0004
Onchocerca volvulus Peroxidase homolog 0.0026 0.0197 0.0644
Plasmodium vivax diacylglycerol kinase, putative 0.0012 0.0052 0.0208
Trypanosoma cruzi ISWI complex protein 0.0018 0.0117 0.1303
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0197 0.0652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0033 0.0111
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0033 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0147 0.0487
Loa Loa (eye worm) oxidoreductase 0.0008 0.0016 0.0053
Echinococcus multilocularis 0.0121 0.1152 0.1138
Echinococcus multilocularis lipoxygenase domain containing protein 0.0178 0.172 0.1707
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0052 0.0126
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.022 0.0679
Brugia malayi EGF-like domain containing protein 0.0009 0.0017 0.0004
Loa Loa (eye worm) VCP protein 0.0037 0.0307 0.102
Plasmodium vivax cell division cycle ATPase, putative 0.0033 0.0261 0.1435
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0057
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0033 0.0111
Echinococcus granulosus neurogenic locus protein delta 0.0009 0.0017 0.0001
Schistosoma mansoni cpg binding protein 0.0029 0.0221 0.0221
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0181 0.1758 0.5834
Schistosoma mansoni slit 0.0009 0.0017 0.0017
Plasmodium falciparum LCCL domain-containing protein 0.0178 0.172 1
Echinococcus granulosus peroxidasin 0.0026 0.0197 0.0181
Schistosoma mansoni hypothetical protein 0.0178 0.172 0.172
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0652
Schistosoma mansoni hypothetical protein 0.0012 0.0052 0.0052
Brugia malayi Bromodomain containing protein 0.0092 0.086 0.3441
Echinococcus multilocularis Diacylglycerol kinase theta 0.0012 0.0052 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0508 0.0508
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0017 0.0001
Schistosoma mansoni protein kinase 0.0052 0.0453 0.0453
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.022 0.0679
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.009 0.0841 0.2943
Schistosoma mansoni hypothetical protein 0.0009 0.0017 0.0017
Echinococcus multilocularis sphingosine kinase 1 0.0306 0.3014 0.3002

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.6746 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (binding) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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