Detailed information for compound 82961

Basic information

Technical information
  • TDR Targets ID: 82961
  • Name: benzyl (2S)-1-[(3-hydroxy-2,2-dimethylpropyl) carbamoyl]piperidine-2-carboxylate
  • MW: 348.437 | Formula: C19H28N2O4
  • H donors: 2 H acceptors: 3 LogP: 2.35 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(CNC(=O)N1CCCC[C@H]1C(=O)OCc1ccccc1)(C)C
  • InChi: 1S/C19H28N2O4/c1-19(2,14-22)13-20-18(24)21-11-7-6-10-16(21)17(23)25-12-15-8-4-3-5-9-15/h3-5,8-9,16,22H,6-7,10-14H2,1-2H3,(H,20,24)/t16-/m0/s1
  • InChiKey: GEYGKLXGCKUOLL-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzyl (2S)-1-[(3-hydroxy-2,2-dimethyl-propyl)carbamoyl]piperidine-2-carboxylate
  • (2S)-1-[[(3-hydroxy-2,2-dimethylpropyl)amino]-oxomethyl]-2-piperidinecarboxylic acid benzyl ester
  • phenylmethyl (2S)-1-[(3-hydroxy-2,2-dimethyl-propyl)carbamoyl]piperidine-2-carboxylate
  • (2S)-1-[(3-hydroxy-2,2-dimethyl-propyl)carbamoyl]pipecolin benzyl ester
  • phenylmethyl (2S)-1-[(3-hydroxy-2,2-dimethylpropyl)carbamoyl]piperidine-2-carboxylate
  • (2S)-1-[[(3-hydroxy-2,2-dimethylpropyl)amino]-oxomethyl]-2-piperidinecarboxylic acid phenylmethyl ester
  • (2S)-1-[(3-hydroxy-2,2-dimethyl-propyl)carbamoyl]pipecolinic acid benzyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens FK506 binding protein 1A, 12kDa Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis fk506 binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis fk506-binding protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium yoelii FK506-binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium knowlesi peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis immunophilin, putative Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09568 FK506-binding protein 1, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) FKBP5 protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09571 FK506-binding protein 4/5, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum FK506-binding protein 1A, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) Get druggable targets OG5_126727 All targets in OG5_126727
Neospora caninum Peptidylprolyl isomerase D (Cyclophilin D), related Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania braziliensis fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania braziliensis peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense peptidylprolyl isomerase-like protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative FK506 binding protein 1A, 12kDa 108 aa 107 aa 48.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus chromobox protein 1 0.001 0.0118 0.0118
Mycobacterium tuberculosis Probable dehydrogenase 0.0012 0.0155 0.0132
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0014 0.0176 0.0157
Onchocerca volvulus Pyruvate kinase homolog 0.001 0.0117 0.0196
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0034 0.0484 0.0584
Trichomonas vaginalis CMGC family protein kinase 0.0008 0.0086 0.0077
Schistosoma mansoni 6-phosphofructokinase 0.0011 0.014 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0698 0.0693
Onchocerca volvulus Pyruvate kinase homolog 0.001 0.0117 0.0196
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0004 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0048 0.0698 0.0702
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0011 0.014 0.0113
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0015 0.0194 0.0195
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0034 0.0478 0.0481
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.0956 0.1153
Entamoeba histolytica phosphofructokinase, putative 0.0011 0.014 0.0127
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0317 0.0318
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0085 0.0102
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0005 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0003 0.0015 0.0015
Echinococcus multilocularis lipoxygenase domain containing protein 0.0013 0.017 0.017
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0003 0.0016 0.0015
Trichomonas vaginalis dullard protein, putative 0.0003 0.0019 0.0009
Trichomonas vaginalis fk506 binding protein, putative 0.0009 0.0105 0.0096
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0004 0.0033 0.0032
Trypanosoma cruzi protein farnesyltransferase, putative 0.0379 0.5709 0.689
Brugia malayi Heterochromatin protein 1 0.001 0.0118 0.0119
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0015 0.0194 0.0195
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0009 0.0105 0.0104
Loa Loa (eye worm) hypothetical protein 0.0003 0.0016 0.0016
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0034 0.0478 0.0576
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0019 0.0264 0.0218
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0241 0.0235
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0003 0.0015 0.0005
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.004 0.0575 0.0577
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Trichomonas vaginalis pyruvate kinase, putative 0.001 0.0117 0.0108
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0308 0.4643 0.4667
Trichomonas vaginalis phosphofructokinase, putative 0.0011 0.014 0.0131
Brugia malayi ImpB/MucB/SamB family protein 0.0013 0.016 0.0161
Echinococcus multilocularis pyruvate kinase 0.0005 0.0045 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.1793 0.1795
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.004 0.0575 0.0577
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0008 0.0086 0.0085
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0379 0.5709 0.5708
Plasmodium falciparum geranylgeranyltransferase, putative 0.0136 0.2025 0.2024
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0003 0.0015 0.0014
Schistosoma mansoni glutaminase 0.0073 0.1068 0.1073
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0379 0.5709 0.5739
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0379 0.5709 0.5735
Mycobacterium tuberculosis Probable reductase 0.0012 0.0155 0.0132
Mycobacterium ulcerans glutaminase 0.0073 0.1068 0.1043
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0057 0.0048
Echinococcus granulosus lamin dm0 0.0004 0.0027 0.0026
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.001 0.0114 0.0082
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.0322 0.0334
Plasmodium vivax pyruvate kinase 2, putative 0.0005 0.0045 0.0044
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0005 0.0039 0.0061
Giardia lamblia Rab geranylgeranyltransferase 0.0308 0.4643 0.4662
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0388 0.585 0.5881
Schistosoma mansoni cpg binding protein 0.0005 0.0037 0.0037
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0003 0.001 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0003 0.0018 0.0017
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0105 0.0125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.001 0.0114 0.0137
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0019 0.0264 0.0263
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.0956 0.1153
Echinococcus granulosus bloom syndrome protein 0.0007 0.0082 0.0081
Loa Loa (eye worm) hypothetical protein 0.0056 0.082 0.0825
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0065 0.0077
Trypanosoma brucei hypothetical protein, conserved 0.0004 0.0028 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0194 0.0195
Loa Loa (eye worm) 6-phosphofructokinase 0.0011 0.014 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0057 0.0048
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0005 0.0051 0.0005
Brugia malayi glutaminase DH11.1 0.0073 0.1068 0.1074
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0003 0.0011 0.001
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0011 0.0132 0.0132
Plasmodium vivax 6-phosphofructokinase, putative 0.0003 0.0015 0.0014
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0136 0.2025 0.2035
Loa Loa (eye worm) hypothetical protein 0.0048 0.0698 0.0702
Trypanosoma cruzi hypothetical protein, conserved 0.0136 0.2025 0.2443
Trichomonas vaginalis phosphofructokinase, putative 0.0011 0.014 0.0131
Loa Loa (eye worm) ICD-1 protein 0.0006 0.0057 0.0058
Echinococcus multilocularis lysine specific demethylase 6a 0.0005 0.0047 0.0046
Brugia malayi jmjC domain containing protein 0.0002 0.0001 0.0001
Echinococcus multilocularis RUN 0.0013 0.017 0.017
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0005 0.0042 0.0049
Schistosoma mansoni DNA helicase recq1 0.0006 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0005 0.0047 0.0047
Echinococcus granulosus dna polymerase kappa 0.0016 0.0217 0.0217
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0012 0.0155 0.0132
Schistosoma mansoni rab6-interacting 0.0013 0.017 0.017
Echinococcus granulosus ryanodine receptor 44f 0.0006 0.0056 0.0055
Brugia malayi Intermediate filament tail domain containing protein 0.0004 0.0027 0.0027
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0012 0.0155 0.0132
Trichomonas vaginalis phosphofructokinase, putative 0.0003 0.0015 0.0005
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0006 0.006 0.006
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0217 0.0261
Trichomonas vaginalis CMGC family protein kinase 0.0008 0.0086 0.0077
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0034 0.0478 0.0766
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0011 0.014 0.0094
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0048 0.0698 0.0791
Echinococcus multilocularis carbonic anhydrase 0.0015 0.0194 0.0194
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0023 0.0322 0.0322
Brugia malayi phosphofructokinase 0.0011 0.014 0.0141
Loa Loa (eye worm) POT family protein 0.0086 0.1278 0.1285
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0015 0.0194 0.0195
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.0105 0.0104
Trichomonas vaginalis penicillin-binding protein, putative 0.0048 0.0698 0.0693
Schistosoma mansoni hypothetical protein 0.0015 0.0194 0.0194
Echinococcus multilocularis mitogen activated protein kinase 0.0008 0.0086 0.0086
Trichomonas vaginalis CMGC family protein kinase 0.0008 0.0086 0.0077
Onchocerca volvulus 0.0048 0.0698 0.1455
Echinococcus multilocularis fk506 binding protein 0.0065 0.0956 0.096
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0041 0.0031
Leishmania major fk506-binding protein 1-like protein 0.0065 0.0956 0.1533
Echinococcus multilocularis lamin 0.0004 0.0027 0.0026
Echinococcus multilocularis cpg binding protein 0.0005 0.0037 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0115 0.0137
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0388 0.585 0.5875
Mycobacterium ulcerans 6-phosphofructokinase 0.0011 0.014 0.0112
Echinococcus granulosus lysine specific demethylase 6a 0.0005 0.0047 0.0046
Echinococcus multilocularis p2X purinoceptor 4 0.0006 0.0053 0.0052
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0009 0.0105 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Trichomonas vaginalis O-linked N-acetylglucosamine transferase, ogt, putative 0.0003 0.0015 0.0005
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0003 0.001 0.0011
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0379 0.5709 0.5735
Leishmania major DNA polymerase eta, putative 0.0014 0.0185 0.0295
Loa Loa (eye worm) hypothetical protein 0.0013 0.017 0.0171
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.006 0.0059
Trichomonas vaginalis set domain proteins, putative 0.0025 0.0355 0.0348
Trypanosoma brucei unspecified product 0.0015 0.0203 0.0244
Schistosoma mansoni DNA polymerase IV / kappa 0.0004 0.0028 0.0027
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0065 0.0956 0.0961
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0698 0.0693
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0065 0.0956 0.0949
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0003 0.0019 0.0018
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0003 0.001 0.0014
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0007 0.0077 0.0076
Brugia malayi exodeoxyribonuclease III family protein 0.001 0.0114 0.0115
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0048 0.0698 0.0791
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.1793 0.1795
Trichomonas vaginalis DNA helicase recq, putative 0.0006 0.0065 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0698 0.0702
Echinococcus granulosus CTD small phosphatase protein like 0.0003 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0085
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0008 0.0086 0.0137
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0659 0.9947 0.9947
Echinococcus granulosus pyruvate kinase 0.0005 0.0045 0.0044
Leishmania major mitochondrial DNA polymerase beta 0.0034 0.0484 0.0776
Trypanosoma cruzi trypanothione reductase, putative 0.0005 0.0051 0.006
Loa Loa (eye worm) matrixin family protein 0.0021 0.0292 0.0293
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0003 0.0015 0.0014
Schistosoma mansoni immunophilin 0.0065 0.0956 0.096
Plasmodium vivax basic transcription factor 3b, putative 0.0006 0.0057 0.0056
Leishmania major pyruvate kinase 0.001 0.0117 0.0186
Brugia malayi jmjC domain containing protein 0.0002 0.0001 0.0001
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0009 0.0105 0.0104
Onchocerca volvulus 0.0009 0.0105 0.0169
Trichomonas vaginalis ap endonuclease, putative 0.001 0.0114 0.0105
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0217 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0174 0.0209
Brugia malayi hypothetical protein 0.0013 0.017 0.0171
Schistosoma mansoni cpg binding protein 0.0005 0.0037 0.0037
Echinococcus granulosus geminin 0.0043 0.0624 0.0627
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0028 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0085 0.0102
Echinococcus multilocularis bloom syndrome protein 0.0007 0.0082 0.0081
Trypanosoma brucei trypanothione reductase 0.0005 0.0051 0.006
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0659 0.9947 0.9947
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.0956 0.1153
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0014 0.0174 0.0278
Schistosoma mansoni carbonic anhydrase 0.0015 0.0194 0.0194
Leishmania major pyruvate kinase 0.001 0.0117 0.0186
Trichomonas vaginalis phosphofructokinase, putative 0.0003 0.0015 0.0005
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.0105 0.0167
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0003 0.0014 0.0014
Echinococcus multilocularis 6 phosphofructokinase 0.0011 0.014 0.014
Trypanosoma cruzi pyruvate kinase 2, putative 0.001 0.0117 0.014
Entamoeba histolytica hypothetical protein, conserved 0.0003 0.0015 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0003 0.0018 0.0017
Brugia malayi Bloom's syndrome protein homolog 0.0007 0.0082 0.0082
Loa Loa (eye worm) FKBP5 protein 0.0065 0.0956 0.0961
Echinococcus granulosus pyruvate kinase 0.0005 0.0045 0.0044
Echinococcus multilocularis dna polymerase eta 0.0023 0.0317 0.0317
Echinococcus granulosus p2X purinoceptor 4 0.0006 0.0053 0.0052
Echinococcus granulosus dna polymerase eta 0.0023 0.0317 0.0317
Toxoplasma gondii ABC1 family protein 0.0048 0.0698 0.0698
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0308 0.4643 0.4667
Trichomonas vaginalis chromobox protein, putative 0.0006 0.0059 0.005
Plasmodium vivax multidomain scavenger receptor, putative 0.0013 0.017 0.0169
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0012 0.0155 0.0132
Brugia malayi Pyruvate kinase, muscle isozyme 0.001 0.0117 0.0118
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0003 0.0018 0.0021
Giardia lamblia Sgs1 DNA helicase, putative 0.0006 0.006 0.0051
Echinococcus granulosus microtubule associated protein 2 0.0351 0.5293 0.5321
Schistosoma mansoni intermediate filament proteins 0.0004 0.0027 0.0026
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0065 0.0956 0.093
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.0322 0.0294
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0009 0.0105 0.0092
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0065 0.0956 0.0952
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0379 0.5709 0.5739
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.001 0.0114 0.0105
Schistosoma mansoni chromobox protein 0.001 0.0118 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0086 0.0086
Trichomonas vaginalis fk506-binding protein, putative 0.0065 0.0956 0.0952
Trypanosoma cruzi hypothetical protein, conserved 0.0003 0.0019 0.0022
Brugia malayi Pyruvate kinase, M2 isozyme 0.001 0.0117 0.0118
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0308 0.4643 0.5603
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0004 0.0022 0.0021
Plasmodium falciparum DNA repair protein REV1, putative 0.0004 0.0028 0.0027
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0388 0.585 0.5881
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0034 0.0478 0.0576
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0023 0.0322 0.0515
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0003 0.0018 0.0017
Toxoplasma gondii peptidylprolyl isomerase 0.0005 0.0039 0.0038
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0065 0.0956 0.0955
Chlamydia trachomatis pyruvate kinase 0.001 0.0117 0.0102
Trypanosoma cruzi DNA damage repair protein, putative 0.0004 0.0028 0.0033
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0034 0.0484 0.0584
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0003 0.0018 0.0017
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0308 0.4643 0.4667
Echinococcus multilocularis pyruvate kinase 0.0005 0.0045 0.0044
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0006 0.006 0.006
Leishmania major hypothetical protein, conserved 0.0003 0.0019 0.0029
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0308 0.4643 0.5603
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0059 0.086 0.0834
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0005 0.0039 0.0046
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0005 0.0047 0.0018
Echinococcus multilocularis pyruvate kinase 0.001 0.0117 0.0117
Brugia malayi MAP kinase sur-1 0.0008 0.0086 0.0087
Brugia malayi Thioredoxin reductase 0.0005 0.0051 0.0051
Plasmodium falciparum glutathione reductase 0.0005 0.0051 0.005
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0065 0.0956 0.0949
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0009 0.0105 0.0105
Treponema pallidum exodeoxyribonuclease (exoA) 0.001 0.0114 0.0099
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0065 0.0956 0.096
Echinococcus multilocularis p2X purinoceptor 4 0.0006 0.0053 0.0052
Trichomonas vaginalis phosphofructokinase, putative 0.0003 0.0015 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.001 0.0114 0.0137
Schistosoma mansoni hypothetical protein 0.0003 0.0018 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Loa Loa (eye worm) hypothetical protein 0.0136 0.2025 0.2036
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0005 0.0042 0.0041
Trypanosoma cruzi transcription factor btf3, putative 0.0006 0.0057 0.0068
Schistosoma mansoni rotamase 0.0005 0.0041 0.004
Treponema pallidum fructose-bisphosphate aldolase 0.012 0.1793 0.1781
Brugia malayi beta-lactamase 0.0048 0.0698 0.0702
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0379 0.5709 0.5739
Schistosoma mansoni microtubule-associated protein tau 0.0351 0.5293 0.5321
Mycobacterium ulcerans hypothetical protein 0.0005 0.0047 0.0018
Loa Loa (eye worm) hypothetical protein 0.0004 0.0037 0.0037
Echinococcus multilocularis Polycystic kidney disease protein 0.0013 0.017 0.017
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0009 0.0105 0.0125
Onchocerca volvulus 0.0005 0.0037 0.0023
Loa Loa (eye worm) hypothetical protein 0.0006 0.0056 0.0056
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0006 0.006 0.0061
Loa Loa (eye worm) hypothetical protein 0.0019 0.0264 0.0265
Mycobacterium tuberculosis Conserved protein 0.0048 0.0698 0.0791
Echinococcus multilocularis carbonic anhydrase 0.0015 0.0194 0.0194
Echinococcus multilocularis 0.0009 0.0105 0.0104
Echinococcus granulosus cpg binding protein 0.0005 0.0037 0.0037
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0014 0.0176 0.013
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0662 1 1
Onchocerca volvulus 0.0004 0.0035 0.0017
Entamoeba histolytica phosphofructokinase, putative 0.0011 0.014 0.0127
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.0105 0.0167
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0003 0.0019 0.0018
Leishmania major carbonic anhydrase-like protein 0.004 0.0575 0.0922
Echinococcus granulosus FK506 binding protein 2 0.0009 0.0105 0.0104
Loa Loa (eye worm) hypothetical protein 0.0136 0.2025 0.2036
Echinococcus granulosus beta LACTamase domain containing family member 0.0048 0.0698 0.0701
Mycobacterium ulcerans lipase LipD 0.0048 0.0698 0.0672
Toxoplasma gondii hypothetical protein 0.0005 0.0052 0.0051
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0003 0.001 0.0009
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0005 0.0041 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0006 0.0057 0.0068
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0009 0.0105 0.0071
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0019 0.0264 0.0264
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0003 0.001 0.0009
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0308 0.4643 0.4667
Schistosoma mansoni carbonic anhydrase-related 0.0015 0.0194 0.0194
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.001 0.0117 0.0086
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0011 0.014 0.0168
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.001 0.0114 0.0182
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0004 0.0028 0.0027
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.001 0.0114 0.0113
Onchocerca volvulus 0.0013 0.017 0.031
Brugia malayi jmjC domain containing protein 0.0002 0.0001 0.0001
Schistosoma mansoni pyruvate kinase 0.001 0.0117 0.0117
Plasmodium falciparum pyruvate kinase 2 0.0005 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0048 0.0698 0.0702
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0136 0.2025 0.2025
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0308 0.4643 0.466
Mycobacterium ulcerans hydrolase 0.0011 0.0132 0.0104
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0015 0.0194 0.0195
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0003 0.0014 0.0013
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0659 0.9947 1
Trypanosoma brucei DNA damage repair protein, putative 0.0004 0.0028 0.0033
Schistosoma mansoni chromobox protein 0.001 0.0118 0.0118
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0065 0.0956 0.0961
Loa Loa (eye worm) hypothetical protein 0.0004 0.0026 0.0026
Trichomonas vaginalis DNA helicase recq1, putative 0.0007 0.0082 0.0072
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0009 0.0105 0.0096
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0388 0.585 0.5881
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0662 1 1
Loa Loa (eye worm) beta-lactamase 0.0048 0.0698 0.0702
Brugia malayi Matrixin family protein 0.0021 0.0292 0.0293
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0004 0.0031 0.003
Echinococcus multilocularis transcription factor btf3 0.0006 0.0057 0.0057
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0003 0.0015 0.0014
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0321 0.4834 0.4859
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0379 0.5709 0.5708
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0379 0.5709 0.5735
Onchocerca volvulus Matrilysin homolog 0.002 0.0265 0.0516
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0023 0.0322 0.0322
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0217 0.0261
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.004 0.0575 0.0693
Giardia lamblia DNA damage repair protein 0.0004 0.0028 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.0185 0.0184
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0048 0.0698 0.0702
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0136 0.2025 0.2024
Trichomonas vaginalis phosphofructokinase, putative 0.0011 0.014 0.0131
Trichomonas vaginalis O-linked N-acetylglucosamine transferase, ogt, putative 0.0003 0.0015 0.0005
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0065 0.0102
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0009 0.0105 0.0104
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0136 0.2025 0.2028
Schistosoma mansoni 6-phosphofructokinase 0.0011 0.014 0.014
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.0105 0.0092
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.0105 0.0125
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0009 0.0105 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0119 0.0143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0003 0.0018 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0115 0.0137
Loa Loa (eye worm) hypothetical protein 0.0009 0.0103 0.0103
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0065 0.0956 0.0942
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0016 0.0213 0.034
Loa Loa (eye worm) CXXC zinc finger family protein 0.0005 0.0037 0.0038
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.0322 0.0294
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0003 0.0015 0.0001
Loa Loa (eye worm) heterochromatin protein 1 0.001 0.0118 0.0119
Schistosoma mansoni carbonic anhydrase-related 0.0015 0.0194 0.0194
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.006 0.0059
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0136 0.2025 0.2036
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0009 0.0105 0.0059
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0379 0.5709 0.5739
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0003 0.0016 0.0018
Brugia malayi jmjC domain containing protein 0.0005 0.0047 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0002 0.0001 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0002 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.1793 0.1795
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0019 0.0264 0.0265
Trichomonas vaginalis O-linked N-acetylglucosamine transferase, ogt, putative 0.0003 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0003 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.0698 0.0702
Schistosoma mansoni DNA helicase recq5 0.0006 0.006 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Schistosoma mansoni P2X receptor subunit 0.0006 0.0053 0.0052
Trichomonas vaginalis ap endonuclease, putative 0.001 0.0114 0.0105
Giardia lamblia DINP protein human, muc B family 0.0014 0.0174 0.0165
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0009 0.0105 0.009
Loa Loa (eye worm) RecQ helicase 0.0007 0.0082 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0698 0.0842
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0007 0.0074 0.0073
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0.0956 0.0952
Echinococcus granulosus p2X purinoceptor 4 0.0006 0.0053 0.0052
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.001 0.0114 0.0137
Echinococcus granulosus expressed protein 0.0005 0.0041 0.004
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0027 0.0383 0.0409
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0034 0.0478 0.048
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0009 0.0105 0.0125
Echinococcus granulosus neuropeptide receptor A26 0.0067 0.0985 0.0989
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0023 0.0322 0.0323
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0136 0.2025 0.2443
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0004 0.0022 0.0022
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0009 0.0105 0.0105
Trichomonas vaginalis DNA helicase recq, putative 0.0007 0.0082 0.0072
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0048 0.0698 0.0702
Loa Loa (eye worm) ryanodine receptor 0.0002 0.0001 0.0001
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0011 0.014 0.0168
Plasmodium falciparum thioredoxin reductase 0.0005 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0006 0.006 0.0061
Loa Loa (eye worm) hypothetical protein 0.0048 0.0698 0.0702
Loa Loa (eye worm) glutaminase 2 0.0073 0.1068 0.1074
Onchocerca volvulus 0.0012 0.0158 0.0285
Loa Loa (eye worm) hypothetical protein 0.0002 0.0001 0.0001
Echinococcus granulosus neuropeptide s receptor 0.0067 0.0985 0.0989
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0009 0.0105 0.0105
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0065 0.0956 0.0955
Mycobacterium tuberculosis Probable esterase LipL 0.0048 0.0698 0.0791
Giardia lamblia Kinase, CMGC MAPK 0.0008 0.0086 0.0077
Leishmania major farnesyltransferase beta subunit 0.0379 0.5709 0.9164
Leishmania major ATP-dependent phosphofructokinase 0.0011 0.014 0.0223
Schistosoma mansoni rab6-interacting 0.0013 0.017 0.017
Schistosoma mansoni hypothetical protein 0.0013 0.017 0.017
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0659 0.9947 1
Loa Loa (eye worm) matrix metalloproteinase 0.0009 0.0103 0.0103
Loa Loa (eye worm) pyruvate kinase 0.001 0.0117 0.0118
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0003 0.0016 0.0018
Schistosoma mansoni carbonic anhydrase-related 0.0015 0.0194 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0015 0.0005
Schistosoma mansoni P2X receptor subunit 0.0006 0.0053 0.0052
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0008 0.0086 0.0137
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0048 0.0698 0.0791
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0698 0.0693
Schistosoma mansoni P2X receptor subunit 0.0006 0.0053 0.0052
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0012 0.0155 0.0132
Echinococcus granulosus lipoxygenase domain containing protein 0.0013 0.017 0.017
Schistosoma mansoni pyruvate kinase 0.0005 0.0045 0.0044
Schistosoma mansoni lamin 0.0004 0.0027 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0043
Brugia malayi intermediate filament protein 0.0004 0.0027 0.0027
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.0105 0.0125
Giardia lamblia Hypothetical protein 0.0009 0.0105 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0117 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0698 0.0842
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0136 0.2025 0.2028
Leishmania major hypothetical protein, conserved 0.0048 0.0698 0.112
Mycobacterium tuberculosis Conserved protein 0.0048 0.0698 0.0791
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0119 0.0143
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.001 0.0114 0.0009
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0003 0.0019 0.0018
Trypanosoma cruzi lanosterol synthase, putative 0.0549 0.8285 1
Schistosoma mansoni polycystin 1-related 0.0013 0.017 0.017
Schistosoma mansoni lipoxygenase 0.0055 0.0809 0.0812
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0136 0.2025 0.2024
Leishmania major DNA polymerase kappa, putative 0.0004 0.0028 0.0044
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0034 0.0484 0.0584
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0034 0.0478 0.0576
Giardia lamblia Pyruvate kinase 0.0005 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0194 0.0195
Mycobacterium tuberculosis Probable lipase LipD 0.0048 0.0698 0.0791
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0006 0.006 0.0059
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0034 0.0478 0.048
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.0956 0.1153
Toxoplasma gondii exonuclease III APE 0.001 0.0114 0.0113
Toxoplasma gondii hypothetical protein 0.0308 0.4643 0.4642
Trypanosoma brucei pyruvate kinase 1 0.001 0.0117 0.014
Schistosoma mansoni pyruvate kinase 0.001 0.0117 0.0117
Trypanosoma brucei carbonic anhydrase-like protein 0.004 0.0575 0.0693
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0003 0.001 0.0011
Giardia lamblia Pyruvate kinase 0.001 0.0117 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.0028 0.0033
Trypanosoma brucei DNA damage repair protein, putative 0.0004 0.0028 0.0033
Loa Loa (eye worm) pyruvate kinase-PB 0.0007 0.0072 0.0073
Echinococcus granulosus 6 phosphofructokinase 0.0011 0.014 0.014
Loa Loa (eye worm) glutathione reductase 0.0005 0.0051 0.0051
Brugia malayi jmjC domain containing protein 0.0002 0.0001 0.0001
Mycobacterium ulcerans beta-lactamase 0.0048 0.0698 0.0672
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0009 0.0105 0.009
Trichomonas vaginalis phosphofructokinase, putative 0.0003 0.0015 0.0005
Trichomonas vaginalis fk506-binding protein, putative 0.0009 0.0105 0.0096
Brugia malayi jmjC domain containing protein 0.0005 0.0052 0.0053
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.082 0.0824
Echinococcus granulosus intermediate filament protein 0.0004 0.0027 0.0026
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0308 0.4643 0.4667
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0136 0.2025 0.2024
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0008 0.0086 0.0103
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0006 0.006 0.006
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0023 0.0322 0.0322
Schistosoma mansoni hypothetical protein 0.0009 0.0105 0.0104
Loa Loa (eye worm) glutaminase 0.0073 0.1068 0.1074
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0015 0.0005
Echinococcus multilocularis p2X purinoceptor 4 0.0006 0.0053 0.0052
Trypanosoma brucei hypothetical protein, conserved 0.0004 0.0028 0.0033
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0005 0.0042 0.0049
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0217 0.0209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.1793 0.1795
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0015 0.0194 0.0195
Schistosoma mansoni cpg binding protein 0.0005 0.0037 0.0037
Loa Loa (eye worm) carbonic anhydrase 3 0.004 0.0575 0.0578
Echinococcus granulosus carbonic anhydrase II 0.004 0.0575 0.0577
Toxoplasma gondii NAC domain-containing protein 0.0006 0.0057 0.0056
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0016 0.0213 0.0256
Trichomonas vaginalis penicillin-binding protein, putative 0.0048 0.0698 0.0693
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0698 0.0842
Brugia malayi CXXC zinc finger family protein 0.0005 0.0037 0.0038
Schistosoma mansoni ryanodine receptor related 0.0009 0.0106 0.0106
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.0956 0.1153
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Brugia malayi POT family protein 0.0086 0.1278 0.1285
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0032 0.0454 0.0456
Schistosoma mansoni lamin 0.0004 0.0027 0.0026
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0048 0.0698 0.0672
Mycobacterium ulcerans pyruvate kinase 0.001 0.0117 0.0089
Loa Loa (eye worm) hypothetical protein 0.0005 0.0047 0.0047
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0065 0.0956 0.096
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0243 0.3652 0.3652
Toxoplasma gondii proteasome regulatory subunit 0.0004 0.0022 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.0028 0.0033
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0379 0.5709 0.689
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0308 0.4643 0.5603
Onchocerca volvulus 0.0048 0.0698 0.1455
Schistosoma mansoni loxhd1 0.0013 0.017 0.017
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0015 0.0194 0.0195
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0079 0.117 0.1175
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0217 0.0217
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0308 0.4643 0.4667
Loa Loa (eye worm) jmjC domain-containing protein 0.0002 0.0001 0.0001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0308 0.4629 0.5562
Trypanosoma cruzi lanosterol synthase, putative 0.0549 0.8285 1
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0003 0.0019 0.0018
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0659 0.9947 1
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0203 0.0244
Leishmania major DNA polymerase eta, putative 0.0023 0.0317 0.0507
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0308 0.4643 0.5603
Loa Loa (eye worm) hypothetical protein 0.0004 0.0035 0.0035
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0185 0.0222
Trichomonas vaginalis phosphofructokinase, putative 0.0003 0.0015 0.0005
Brugia malayi 6-phosphofructokinase 0.0011 0.014 0.0141
Mycobacterium ulcerans epimerase 0.0005 0.0047 0.0018
Entamoeba histolytica deoxycytidyl transferase, putative 0.0013 0.016 0.0147
Brugia malayi Pre-SET motif family protein 0.0003 0.0018 0.0018
Brugia malayi Matrixin family protein 0.0009 0.0103 0.0103
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0013 0.016 0.0161
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.082 0.0824
Onchocerca volvulus 0.0009 0.0105 0.0169
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0003 0.0019 0.0009
Schistosoma mansoni immunophilin 0.0065 0.0956 0.096
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0009 0.0105 0.0125
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Onchocerca volvulus 0.0308 0.4643 1
Trichomonas vaginalis immunophilin, putative 0.0065 0.0956 0.0952
Echinococcus multilocularis microtubule associated protein 2 0.0351 0.5293 0.5321
Entamoeba histolytica recQ family DNA helicase 0.0003 0.0016 0.0002
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0008 0.0086 0.0087
Schistosoma mansoni ap endonuclease 0.001 0.0114 0.0114
Onchocerca volvulus Matrilysin homolog 0.0009 0.0103 0.0164
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0059 0.086 0.0987
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0003 0.0019 0.0018
Trichomonas vaginalis fk506-binding protein, putative 0.0009 0.0105 0.0096
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0659 0.9947 1
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0065 0.0956 0.0952
Echinococcus granulosus p2X purinoceptor 4 0.0006 0.0053 0.0052
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0003 0.0019 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0015 0.0005
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0009 0.0105 0.0105
Echinococcus multilocularis lamin dm0 0.0004 0.0027 0.0026
Echinococcus multilocularis thioredoxin glutathione reductase 0.0005 0.0051 0.005
Schistosoma mansoni fk506 binding protein 0.0009 0.0105 0.0104
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0005 0.0042 0.0049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0317 0.0318
Loa Loa (eye worm) jmjC domain-containing protein 0.0002 0.0001 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0308 0.4643 0.5603
Mycobacterium leprae Probable pyruvate kinase PykA 0.001 0.0117 0.0071
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0662 1 1
Onchocerca volvulus 0.0005 0.0042 0.0033
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.001 0.0114 0.0114
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0009 0.0105 0.0105
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0003 0.0019 0.0009
Brugia malayi Putative carbonic anhydrase 5 precursor 0.004 0.0575 0.0578
Schistosoma mansoni transcription factor btf3 0.0006 0.0057 0.0057
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0004 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0012 0.0158 0.0158
Trichomonas vaginalis chromobox protein, putative 0.001 0.0118 0.0109
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0013 0.016 0.016
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0008 0.0086 0.0103
Brugia malayi cation channel family protein 0.0004 0.0028 0.0028
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0003 0.0019 0.0009
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0008 0.0086 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Trypanosoma brucei unspecified product 0.0009 0.0101 0.012
Echinococcus granulosus chromobox protein 1 0.001 0.0118 0.0118
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0014 0.0176 0.0157
Leishmania major DNA polymerase kappa, putative 0.0014 0.0174 0.0278
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0065 0.0077
Echinococcus multilocularis beta LACTamase domain containing family member 0.0048 0.0698 0.0701
Leishmania major lanosterol synthase, putative 0.0413 0.6229 1
Toxoplasma gondii thioredoxin reductase 0.0005 0.0051 0.005
Echinococcus multilocularis pyruvate kinase 0.0008 0.0086 0.0085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.1793 0.1795
Toxoplasma gondii endonuclease IV APN 0.0019 0.0264 0.0263
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0549 0.8285 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.001 0.0114 0.0101
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0308 0.4643 0.5603
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Plasmodium vivax geranylgeranyltransferase, putative 0.0136 0.2025 0.2024
Toxoplasma gondii pyruvate kinase PyK1 0.001 0.0117 0.0116
Toxoplasma gondii hypothetical protein 0.035 0.5273 0.5273
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0013 0.0168 0.0147
Brugia malayi Doublecortin family protein 0.0013 0.017 0.0171
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0006 0.006 0.006
Echinococcus granulosus lamin 0.0004 0.0027 0.0026
Echinococcus granulosus ryanodine receptor 44f 0.0007 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0132
Echinococcus granulosus carbonic anhydrase 0.0015 0.0194 0.0194
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.1793 0.1795
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0013 0.0168 0.0122
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.035 0.5273 0.5297
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0005 0.0039 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.0011 0.014 0.0131
Toxoplasma gondii phosphofructokinase PFKII 0.0003 0.0015 0.0014
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0005 0.0039 0.0046
Trypanosoma cruzi pyruvate kinase 2, putative 0.001 0.0117 0.014
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0006 0.006 0.0061
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0381 0.5739 0.691
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.001 0.0114 0.0115
Echinococcus multilocularis chromobox protein 1 0.001 0.0118 0.0118
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0003 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0043 0.0624 0.0627
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.0662 1 1
Leishmania major hypothetical protein, conserved 0.001 0.0119 0.019
Brugia malayi polk-prov protein 0.0008 0.0085 0.0086
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0662 1 1
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0003 0.0019 0.0005
Echinococcus multilocularis neuropeptide receptor A26 0.0067 0.0985 0.0989
Echinococcus multilocularis pyruvate kinase 0.0005 0.0045 0.0044
Mycobacterium tuberculosis Probable lipase LipE 0.0048 0.0698 0.0791
Echinococcus granulosus RUN 0.0013 0.017 0.017
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.0956 0.1153
Trypanosoma cruzi hypothetical protein, conserved 0.0136 0.2025 0.2443
Loa Loa (eye worm) phosphofructokinase 0.0011 0.014 0.0141
Loa Loa (eye worm) pyruvate kinase 0.001 0.0117 0.0118
Trichomonas vaginalis O-linked N-acetylglucosamine transferase, ogt, putative 0.0003 0.0015 0.0005
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0.0956 0.0952
Loa Loa (eye worm) hypothetical protein 0.0007 0.0072 0.0073
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0005 0.0042 0.0041
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.004 0.0575 0.0578
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0003 0.0019 0.0022
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0698 0.0655
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0115 0.0137
Echinococcus granulosus carbonic anhydrase 0.0015 0.0194 0.0194
Echinococcus multilocularis mitogen activated protein kinase 3 0.0008 0.0086 0.0086
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.001 0.0114 0.0086
Trypanosoma brucei pyruvate kinase 1, putative 0.001 0.0117 0.014
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0005 0.0047 0.0043
Trypanosoma cruzi DNA damage repair protein, putative 0.0004 0.0028 0.0033
Entamoeba histolytica transcription factor BTF3, putative 0.0006 0.0057 0.0044
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0013 0.016 0.016
Trypanosoma brucei chrX additional, unordered contigs 0.0004 0.0028 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0004 0.0027 0.0027
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0379 0.5709 0.5735
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0004 0.0022 0.0009
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0388 0.585 0.5881
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0008 0.0086 0.0103
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0317 0.0381
Trichomonas vaginalis O-linked N-acetylglucosamine transferase, ogt, putative 0.0003 0.0015 0.0005
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0011 0.0132 0.0103
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0009 0.0105 0.0096
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0065 0.0956 0.096
Echinococcus multilocularis ryanodine receptor 44f 0.0006 0.0056 0.0055
Brugia malayi beta-NAC-like protein 0.0006 0.0057 0.0058
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.0105 0.0125
Loa Loa (eye worm) ryanodine receptor 0.0003 0.002 0.002
Echinococcus multilocularis transcription factor Dp 1 0.0019 0.0264 0.0264
Trypanosoma cruzi transcription factor btf3, putative 0.0006 0.0057 0.0068
Mycobacterium ulcerans endonuclease IV 0.0019 0.0264 0.0236
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0388 0.585 0.5881
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0015 0.0005
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0308 0.4643 0.4642
Echinococcus multilocularis expressed protein 0.0005 0.0041 0.004
Plasmodium vivax thioredoxin reductase, putative 0.0005 0.0051 0.005
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0659 0.9947 1
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0009 0.0105 0.0125
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0004 0.0022 0.0023
Echinococcus multilocularis chromobox protein 1 0.001 0.0118 0.0118
Mycobacterium ulcerans esterase/lipase LipP 0.0048 0.0698 0.0672
Brugia malayi Matrixin family protein 0.0009 0.0103 0.0103
Trichomonas vaginalis rotamase, putative 0.0005 0.0041 0.0031
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0003 0.0019 0.0018
Schistosoma mansoni P2X receptor subunit 0.0006 0.0053 0.0052
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0005 0.0041 0.0041
Echinococcus multilocularis carbonic anhydrase 0.0015 0.0194 0.0194
Echinococcus granulosus transcription factor Dp 1 0.0019 0.0264 0.0264
Trypanosoma brucei transcription factor BTF3, putative 0.0006 0.0057 0.0068
Echinococcus granulosus Polycystic kidney disease protein 0.0013 0.017 0.017
Echinococcus granulosus carbonic anhydrase 0.0015 0.0194 0.0194
Schistosoma mansoni lipoxygenase 0.0079 0.117 0.1175
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0003 0.0015 0.0005
Leishmania major geranylgeranyltransferase, putative 0.0136 0.2025 0.325
Loa Loa (eye worm) hypothetical protein 0.0009 0.0105 0.0105
Trichomonas vaginalis rotamase, putative 0.0005 0.0039 0.0029
Plasmodium vivax pyruvate kinase, putative 0.001 0.0117 0.0116
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.0105 0.0104
Giardia lamblia Rab geranylgeranyltransferase 0.0659 0.9947 1
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0004 0.0022 0.0023
Onchocerca volvulus 0.0025 0.0355 0.0712
Trypanosoma cruzi protein farnesyltransferase, putative 0.0379 0.5709 0.689
Giardia lamblia Fructose-bisphosphate aldolase 0.012 0.1793 0.1795
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0659 0.9947 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0003 0.0019 0.0018
Echinococcus granulosus pyruvate kinase 0.001 0.0117 0.0117
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0317 0.0381
Trypanosoma brucei unspecified product 0.0009 0.0101 0.012
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0217 0.0189
Echinococcus granulosus pyruvate kinase 0.0005 0.0045 0.0044
Loa Loa (eye worm) 6-phosphofructokinase 0.0011 0.014 0.0141
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0659 0.9947 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.004 0.0575 0.0578
Echinococcus multilocularis geminin 0.0043 0.0624 0.0627
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0698 0.0698
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0014 0.0174 0.0155
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0004 0.0022 0.0023
Trichomonas vaginalis dullard protein, putative 0.0003 0.0019 0.0009
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0006 0.006 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0043
Entamoeba histolytica phosphofructokinase, putative 0.0011 0.014 0.0127
Mycobacterium leprae PROBABLE HYDROLASE 0.0011 0.0132 0.0085
Trichomonas vaginalis chromobox protein, putative 0.001 0.0118 0.0109
Leishmania major basic transcription factor 3a, putative 0.0006 0.0057 0.0091
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0308 0.4643 0.4642
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0662 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0013 0.017 0.017
Giardia lamblia Prenyltransferase 0.0379 0.5709 0.5735
Brugia malayi chromobox protein homolog 3 0.0006 0.0053 0.0053
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0027 0.0383 0.0356
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0022 0.0298 0.0299
Echinococcus multilocularis ryanodine receptor 44f 0.0007 0.008 0.0079
Onchocerca volvulus 0.0009 0.0103 0.0164
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0003 0.0019 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0003 0.0015 0.0005
Entamoeba histolytica pyruvate kinase, putative 0.0007 0.0072 0.0059
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0012 0.0155 0.0109
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0308 0.4643 0.4662
Loa Loa (eye worm) hypothetical protein 0.0006 0.0053 0.0053
Brugia malayi jmjC domain containing protein 0.0002 0.0001 0.0001
Trypanosoma brucei beta lactamase 0.0013 0.0168 0.0202
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0005 0.0047 0.0046
Echinococcus granulosus lipoxygenase domain containing protein 0.0013 0.017 0.017
Loa Loa (eye worm) pyruvate kinase 0.001 0.0117 0.0118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0048 0.0698 0.0701
Plasmodium falciparum basic transcription factor 3b, putative 0.0006 0.0057 0.0056
Schistosoma mansoni ap endonuclease 0.001 0.0114 0.0114
Plasmodium falciparum carbonic anhydrase 0.0015 0.0194 0.0193
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0379 0.5709 0.5739
Loa Loa (eye worm) hypothetical protein 0.0009 0.0103 0.0103
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0388 0.585 0.5881
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0011 0.014 0.0125
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0136 0.2025 0.2035
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.012 0.1793 0.1791
Echinococcus multilocularis musashi 0.0004 0.0027 0.0026
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0136 0.2025 0.2443
Trichomonas vaginalis glutaminase, putative 0.0073 0.1068 0.1065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0194 0.0195
Mycobacterium tuberculosis Probable oxidoreductase 0.0014 0.0176 0.0157
Plasmodium vivax DNA repair protein REV1, putative 0.0004 0.0028 0.0027
Entamoeba histolytica hypothetical protein 0.0006 0.0057 0.0044
Plasmodium falciparum LCCL domain-containing protein 0.0013 0.017 0.0169
Toxoplasma gondii pyruvate kinase PyKII 0.0005 0.0045 0.0044
Onchocerca volvulus Matrix metalloproteinase homolog 0.002 0.0265 0.0516
Brugia malayi Pre-SET motif family protein 0.0022 0.0308 0.031
Loa Loa (eye worm) doublecortin family protein 0.0013 0.017 0.0171
Mycobacterium tuberculosis Conserved hypothetical protein 0.0013 0.016 0.0138
Plasmodium vivax 6-phosphofructokinase, putative 0.0003 0.0015 0.0014
Echinococcus granulosus mitogen activated protein kinase 0.0008 0.0086 0.0086
Onchocerca volvulus 0.0048 0.0698 0.1455
Loa Loa (eye worm) hypothetical protein 0.0008 0.0085 0.0086
Trichomonas vaginalis dullard protein, putative 0.0003 0.0019 0.0009
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0003 0.0019 0.0019
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0019 0.0264 0.0263
Echinococcus granulosus histone lysine methyltransferase setb 0.0003 0.0018 0.0017
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0009 0.0105 0.0167
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0009 0.0105 0.0105
Schistosoma mansoni hypothetical protein 0.0043 0.0624 0.0627
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0009 0.0105 0.0104
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0005 0.0039 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0105 0.0096
Loa Loa (eye worm) thioredoxin reductase 0.0005 0.0051 0.0051
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0009 0.0103 0.0102
Schistosoma mansoni hypothetical protein 0.0002 0.0003 0.0002
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0009 0.0105 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0105 0.0096
Trichomonas vaginalis chromobox protein, putative 0.0006 0.0059 0.005
Brugia malayi Matrixin family protein 0.0009 0.0103 0.0103
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0016 0.0213 0.0256
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0003 0.0018 0.0021
Echinococcus granulosus transcription factor btf3 0.0006 0.0057 0.0057
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0388 0.585 0.5877
Entamoeba histolytica recQ family helicase, putative 0.0006 0.0065 0.0051
Mycobacterium ulcerans hypothetical protein 0.0009 0.0105 0.0077
Brugia malayi jmjC domain containing protein 0.0005 0.0052 0.0053
Schistosoma mansoni DNA polymerase eta 0.0023 0.0317 0.0317
Brugia malayi beta-lactamase family protein 0.0048 0.0698 0.0702
Trichomonas vaginalis O-linked N-acetylglucosamine transferase, ogt, putative 0.0003 0.0015 0.0005
Schistosoma mansoni blooms syndrome DNA helicase 0.0004 0.0035 0.0034
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0659 0.9947 1
Brugia malayi beta-lactamase family protein 0.0048 0.0698 0.0702
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.001 0.0114 0.0114
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0034 0.0478 0.0468
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0022 0.0308 0.031
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0005 0.0042 0.0049
Trypanosoma brucei protein kinase, putative 0.0008 0.0086 0.0103
Mycobacterium tuberculosis Probable hydrolase 0.0048 0.0698 0.0791
Echinococcus granulosus thioredoxin glutathione reductase 0.0005 0.0051 0.005
Echinococcus multilocularis neuropeptide s receptor 0.0067 0.0985 0.0989
Toxoplasma gondii 6-phosphofructokinase 0.0003 0.0015 0.0014
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.001 0.0114 0.0113
Echinococcus multilocularis 0.0003 0.0019 0.0018
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0217 0.0209
Schistosoma mansoni blooms syndrome DNA helicase 0.0003 0.0016 0.0015
Schistosoma mansoni terminal deoxycytidyl transferase 0.0013 0.016 0.016
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.004 0.0575 0.0693
Brugia malayi glutathione reductase 0.0005 0.0051 0.0051
Onchocerca volvulus 0.0013 0.017 0.031
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0065 0.0956 0.0961
Echinococcus granulosus pyruvate kinase 0.001 0.0117 0.0117
Trypanosoma brucei lanosterol synthase 0.0549 0.8285 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0008 0.0086 0.0103
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.012 0.1793 0.1791
Loa Loa (eye worm) hypothetical protein 0.0003 0.0018 0.0018
Loa Loa (eye worm) matrixin family protein 0.002 0.0265 0.0267
Leishmania major hypothetical protein, conserved 0.0002 0.0003 0.0003
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0032 0.0454 0.0456
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0006 0.0053 0.0056
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0009 0.0105 0.0125
Loa Loa (eye worm) hypothetical protein 0.0003 0.0015 0.0015
Brugia malayi hypothetical protein 0.0013 0.017 0.0171
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0379 0.5709 0.5735
Mycobacterium tuberculosis Conserved protein 0.0048 0.0698 0.0791
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0006 0.0059 0.007
Brugia malayi 6-phosphofructokinase 0.0011 0.014 0.0141
Leishmania major DNA damage repair protein, putative 0.0004 0.0028 0.0044
Echinococcus multilocularis pyruvate kinase 0.001 0.0117 0.0117
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0308 0.4643 0.7453
Brugia malayi Matrixin family protein 0.0009 0.0103 0.0103
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0662 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0004 0.0027 0.0027
Brugia malayi Hemopexin family protein 0.0012 0.0158 0.0159
Toxoplasma gondii hypothetical protein 0.0015 0.0194 0.0193
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0065 0.0956 0.096
Loa Loa (eye worm) hypothetical protein 0.0013 0.017 0.0171
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.1793 0.1795
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0379 0.5709 0.5735
Chlamydia trachomatis endonuclease IV 0.0019 0.0264 0.0249
Trichomonas vaginalis pyruvate kinase, putative 0.001 0.0117 0.0108
Mycobacterium ulcerans hypothetical protein 0.0048 0.0698 0.0672
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0003 0.0018 0.0017
Mycobacterium ulcerans hypothetical protein 0.0018 0.0241 0.0213
Mycobacterium leprae Probable lipase LipE 0.0048 0.0698 0.0655
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0379 0.5709 0.5708
Echinococcus multilocularis carbonic anhydrase II 0.004 0.0575 0.0577
Leishmania major trypanothione reductase 0.0005 0.0051 0.008
Trichomonas vaginalis CMGC family protein kinase 0.0008 0.0086 0.0077
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0079 0.117 0.1175
Schistosoma mansoni immunophilin 0.0056 0.082 0.0824
Echinococcus granulosus mitogen activated protein kinase 3 0.0008 0.0086 0.0086
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0003 0.0019 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0308 0.4643 0.5603
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0659 0.9947 1
Loa Loa (eye worm) hypothetical protein 0.0659 0.9947 1
Trichomonas vaginalis O-linked N-acetylglucosamine transferase, ogt, putative 0.0003 0.0015 0.0005
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0136 0.2025 0.2024
Giardia lamblia Rab geranylgeranyltransferase 0.0136 0.2025 0.2028
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0057 0.0048
Loa Loa (eye worm) proteasome 26S subunit 0.0003 0.001 0.001
Plasmodium falciparum pyruvate kinase 0.001 0.0117 0.0116
Loa Loa (eye worm) hypothetical protein 0.0004 0.0027 0.0027
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0034 0.0478 0.048
Trichomonas vaginalis esterase, putative 0.0048 0.0698 0.0693
Plasmodium vivax glutathione reductase, putative 0.0005 0.0051 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0308 0.4643 0.5603
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0028 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0217 0.0261
Leishmania major peptidylprolyl isomerase-like protein 0.0065 0.0956 0.1533
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0308 0.4643 0.5603
Plasmodium vivax SET domain protein, putative 0.0003 0.0018 0.0017
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0379 0.5709 0.5733
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0048 0.0698 0.0701
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0009 0.0106 0.0107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.1793 0.1795
Onchocerca volvulus Pyruvate kinase homolog 0.001 0.0117 0.0196
Mycobacterium ulcerans lipoprotein LpqF 0.0013 0.0168 0.014
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0034 0.0478 0.0481
Loa Loa (eye worm) hypothetical protein 0.0003 0.0019 0.0019
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0059 0.086 0.0817

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 8.4 uM Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12 ChEMBL. 8627611
Ki app (binding) = 8.4 uM Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12 ChEMBL. 8627611

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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