Detailed information for compound 829808

Basic information

Technical information
  • TDR Targets ID: 829808
  • Name: 9-[(4-fluorophenyl)methyl]-4-(4-methoxyphenyl )-8,10-dihydropyrano[6,5-f][1,3]benzoxazin-2- one
  • MW: 417.429 | Formula: C25H20FNO4
  • H donors: 0 H acceptors: 1 LogP: 4.33 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1cc(=O)oc2c1ccc1c2CN(CO1)Cc1ccc(cc1)F
  • InChi: 1S/C25H20FNO4/c1-29-19-8-4-17(5-9-19)21-12-24(28)31-25-20(21)10-11-23-22(25)14-27(15-30-23)13-16-2-6-18(26)7-3-16/h2-12H,13-15H2,1H3
  • InChiKey: PXYOGWFHUSGTGE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 9-(4-fluorobenzyl)-4-(4-methoxyphenyl)-8,10-dihydropyrano[6,5-f][1,3]benzoxazin-2-one
  • ST5327608

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum (isolate 3D7) Proline--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 Starlite/ChEMBL No references
Plasmodium falciparum calcium-dependent protein kinase 1 Starlite/ChEMBL No references
Plasmodium falciparum lysine--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum hexose transporter Starlite/ChEMBL No references
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Starlite/ChEMBL No references
Plasmodium falciparum mitogen-activated protein kinase 2 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 7 Starlite/ChEMBL No references
Leishmania mexicana glucose transporter, lmgt2 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 6 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium vivax lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium leprae Probable prolyl tRNA synthetase ProS Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis solute carrier family 2, facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K01881 prolyl-tRNA synthetase [EC6.1.1.15], putative Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Theileria parva lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei gambiense glucose transporter,glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense glucose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum Glucose transporter 1A, related Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum expressed protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter 1E Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium knowlesi CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Plasmodium falciparum lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter 2A Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi protein kinase 7, putative Get druggable targets OG5_145294 All targets in OG5_145294
Entamoeba histolytica prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii facilitative glucose transporter GT1 Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum IPR005828,General substrate transporter,domain-containing Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania braziliensis lmgt2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Candida albicans hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi hexose transporter, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Giardia lamblia Lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum protein kinase, PfPK7 homolog, putative Get druggable targets OG5_145294 All targets in OG5_145294
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter 1 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum proline-tRNA synthetase; class II aaRS (ybak RNA binding domain plus tRNA synthetase) Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Giardia lamblia Prolyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Babesia bovis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Brugia malayi Sugar transporter family protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 1, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum lysyl-tRNA synthetase (NOB+tRNA synthetase) Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Chlamydia trachomatis lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum IPR000924,Glutamyl-tRNA synthetase, class Ic;IPR001412,Aminoacyl-tRNA synthetase, class I,domain-containing Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Babesia bovis mitogen-activated protein kinase, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium yoelii mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii cdk-related protein kinase 6-related Get druggable targets OG5_155179 All targets in OG5_155179
Echinococcus granulosus General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K04567 lysyl-tRNA synthetase, class II, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Cryptosporidium hominis aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 4, putative Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii putative sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania mexicana glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Toxoplasma gondii lysine-tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania donovani lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii Ser/Thr protein kinase Get druggable targets OG5_145294 All targets in OG5_145294
Leishmania infantum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 3, putative Get druggable targets OG5_127135 All targets in OG5_127135
Brugia malayi lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium hominis Kars protein Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Echinococcus multilocularis General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum CMGC kinase, MAPK family, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter 3, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Theileria parva prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium berghei mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium hominis calcium-dependent protein kinase Calcium-dependent protein kinase 4   528 aa 502 aa 29.7 %
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Leishmania major protein kinase, putative Calcium-dependent protein kinase 4   528 aa 488 aa 27.5 %
Theileria parva protein kinase, putative Calcium-dependent protein kinase 4   528 aa 507 aa 27.4 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands Calcium-dependent protein kinase 4   528 aa 501 aa 28.9 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 509 aa 25.5 %
Babesia bovis calcium-dependent protein kinase, putative Calcium-dependent protein kinase 4   528 aa 450 aa 30.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 517 aa 27.9 %
Toxoplasma gondii calcium-dependent protein kinase CDPK2 Calcium-dependent protein kinase 4   528 aa 480 aa 36.9 %
Theileria parva calmodulin-domain protein kinase, putative Calcium-dependent protein kinase 4   528 aa 454 aa 31.9 %
Trypanosoma brucei glucose transporter, putative solute carrier family 2 (facilitated glucose transporter), member 1 492 aa 395 aa 23.5 %
Giardia lamblia Kinase, NEK Calcium-dependent protein kinase 4   528 aa 509 aa 19.8 %
Cryptosporidium hominis hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Babesia bovis mitogen-activated protein kinase, putative Calcium-dependent protein kinase 4   528 aa 427 aa 23.4 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Calcium-dependent protein kinase 4   528 aa 468 aa 35.9 %
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase 7 343 aa 310 aa 25.2 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 29.0 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 522 aa 25.5 %
Cryptosporidium hominis calmodulin-domain protein kinase 2 Calcium-dependent protein kinase 4   528 aa 468 aa 36.1 %
Neospora caninum Calcium-dependent protein kinase, related Calcium-dependent protein kinase 4   528 aa 516 aa 35.5 %
Leishmania braziliensis protein kinase, putative Calcium-dependent protein kinase 4   528 aa 490 aa 27.3 %
Toxoplasma gondii calcium-dependent protein kinase CDPK6 Calcium-dependent protein kinase 4   528 aa 453 aa 34.0 %
Leishmania infantum protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Toxoplasma gondii calcium-dependent protein kinase CDPK9 Calcium-dependent protein kinase 4   528 aa 500 aa 34.2 %
Leishmania mexicana protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.2 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 527 aa 25.6 %
Cryptosporidium parvum hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Entamoeba histolytica protein kinase, putative Calcium-dependent protein kinase 4   528 aa 429 aa 26.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 protein kinase 6 305 aa 338 aa 27.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 499 aa 29.3 %
Neospora caninum CAM kinase, CDPK family, putative Calcium-dependent protein kinase 4   528 aa 463 aa 32.0 %
Trypanosoma brucei protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Leishmania donovani protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Trypanosoma brucei glucose transporter, putative hexose transporter 504 aa 426 aa 22.3 %
Trypanosoma brucei gambiense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0071 0.0099
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0007 0.0041 0.0035
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.2199 0.2185
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0525 0.1259
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0505 1
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0224 0.0324
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3969 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.0038
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0007 0.0041 0.0035
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0007 0.0041 0.0035
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0295 0.5587
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Onchocerca volvulus 0.0018 0.0202 0.0633
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0517 0.0736
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0525 0.868
Echinococcus multilocularis ferritin 0.0009 0.0066 0.0073
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0224 0.0324
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0066 0.1417
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2581 0.6479
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0066 0.267
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0359 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0224 0.0207
Brugia malayi hypothetical protein 0.0009 0.0077 0.006
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0007 0.0041 0.0035
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0202 1
Trypanosoma brucei glucose transporter, putative 0.0039 0.0525 0.1071
Leishmania major glucose transporter, lmgt1 0.0039 0.0525 0.868
Brugia malayi hypothetical protein 0.0018 0.0202 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0038
Schistosoma mansoni thyrotroph embryonic factor related 0.0009 0.0077 0.0108
Giardia lamblia Glycyl-tRNA synthetase 0.0007 0.0041 0.0002
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0505 0.0737
Loa Loa (eye worm) histone methyltransferase 0.001 0.0083 0.0067
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0295 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0202 0.0272
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3969 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0518 0.0597
Loa Loa (eye worm) hypothetical protein 0.0019 0.0224 0.0207
Echinococcus granulosus KRAB A domain containing protein 0.0007 0.0041 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2581 0.6479
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.06 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0066 0.1574
Trichomonas vaginalis rotamase, putative 0.0035 0.0456 0.1084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0071 0.0079
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.2724 0.684
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Loa Loa (eye worm) hypothetical protein 0.0038 0.0505 0.0489
Brugia malayi ecdysone receptor 0.0009 0.0071 0.0054
Echinococcus granulosus cpg binding protein 0.0034 0.0445 0.0629
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0185 0.0168
Brugia malayi ecdysteroid receptor 0.0019 0.0224 0.0207
Trypanosoma brucei ingi protein (ORF1) 0.0007 0.0041 0.0027
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.0136 0.2978
Onchocerca volvulus 0.0009 0.0077 0.014
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.2199 0.3208
Brugia malayi Hepatic leukemia factor 0.0009 0.0077 0.006
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0007 0.0041 0.0035
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 0.8019 1
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0202 0.0439
Echinococcus multilocularis RNA directed DNA polymerase 0.0007 0.0041 0.0035
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0007 0.0041 0.0262
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0071 0.0054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.0038
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0007 0.0041 0.0027
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Onchocerca volvulus 0.0018 0.0202 0.0633
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.006
Echinococcus granulosus Threonyl tRNA synthetase C 0.0007 0.0041 0.0036
Schistosoma mansoni ferritin 0.0009 0.0066 0.0093
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0007 0.0041 0.0024
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.048 0.7901
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0224 0.0207
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0007 0.0041 0.0036
Brugia malayi tailless protein 0.0009 0.0071 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0054 0.0074
Trypanosoma brucei glucose transporter, putative 0.0039 0.0525 0.1071
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0518 0.0645
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0007 0.0041 0.0377
Echinococcus granulosus solute carrier family 22 0.0018 0.0202 0.0272
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0071 0.0079
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0224 0.0324
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0544 1
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0136 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0444 0.7995
Trypanosoma brucei glucose transporter, putative 0.0039 0.0525 0.1071
Onchocerca volvulus 0.0009 0.0077 0.014
Schistosoma mansoni hypothetical protein 0.0175 0.2582 0.3784
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0224 0.0324
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0518 0.0925
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2581 0.6479
Schistosoma mansoni glucose transport protein 0.0126 0.1839 0.2694
Echinococcus granulosus RNA directed DNA polymerase 0.0007 0.0041 0.0035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0224 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0224 0.0207
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1839 0.268
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0417 0.0401
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0525 0.1259
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0202 0.0185
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.0038
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0093 0.1119
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0202 0.0439
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0038
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0224 0.0304
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0202 0.0374
Schistosoma mansoni protein kinase 0.0039 0.0517 0.0754
Brugia malayi hypothetical protein 0.0007 0.0041 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0525 0.1259
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.0009 0.0077 0.0088
Trypanosoma cruzi hexose transporter 0.0039 0.0525 0.868
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0202 0.0272
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0187 0.0269
Schistosoma mansoni cpg binding protein 0.0032 0.0417 0.0608
Onchocerca volvulus 0.0009 0.0077 0.014
Echinococcus granulosus solute carrier family 22 0.0018 0.0202 0.0272
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0224 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.006
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0359 0.0522
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2581 0.6479
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0307 0.0706
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0087 0.0103
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0007 0.0041 0.0031
Brugia malayi major facilitator superfamily protein 0.0018 0.0202 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1839 0.4594
Plasmodium vivax threonine--tRNA ligase, putative 0.0007 0.0041 0.0051
Schistosoma mansoni hypothetical protein 0.0298 0.4435 0.6505
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Brugia malayi reverse transcriptase 0.0007 0.0041 0.0024
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0224 0.0207
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0359 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0043 0.0038
Schistosoma mansoni sugar transporter 0.0018 0.0202 0.0291
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0087 0.007
Schistosoma mansoni ferritin 0.0009 0.0066 0.0093
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0009 0.0077 0.0088
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0517 0.0736
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0009 0.0077 0.0088
Onchocerca volvulus 0.0018 0.0202 0.0633
Onchocerca volvulus Putative transporter 0.0018 0.0202 0.0633
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0202 0.303
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0359 0.5783
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0505 0.9226
Entamoeba histolytica hypothetical protein 0.0009 0.0077 0.0704
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0224 0.0207
Echinococcus granulosus glycyl tRNA synthetase 0.0007 0.0041 0.0036
Echinococcus multilocularis dnaJ subfamily B 0.0456 0.6816 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0087 0.0123
Onchocerca volvulus 0.0018 0.0202 0.0633
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0202 0.5239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Leishmania major basic transcription factor 3a, putative 0.0036 0.048 0.7901
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0224 0.0324
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0071 0.0099
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0202 0.303
Onchocerca volvulus 0.0018 0.0202 0.0633
Plasmodium falciparum hexose transporter 0.0126 0.1839 0.2253
Trypanosoma brucei glucose transporter, putative 0.0039 0.0525 0.1071
Plasmodium falciparum proline--tRNA ligase 0.0044 0.06 0.0701
Brugia malayi Zinc knuckle family protein 0.0007 0.0041 0.0024
Onchocerca volvulus 0.0018 0.0202 0.0633
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0071 0.0079
Schistosoma mansoni coup transcription factor 0.0019 0.0224 0.0324
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0202 0.0201
Brugia malayi Protein kinase domain containing protein 0.0019 0.0221 0.0204
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0007 0.0041 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0456 0.1084
Toxoplasma gondii NAC domain-containing protein 0.0036 0.048 0.0854
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.1839 0.3424
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0517 0.0736
Onchocerca volvulus 0.0018 0.0202 0.0633
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0202 0.0439
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0071 0.0079
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0007 0.0041 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0071 0.0079
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0007 0.0041 0.0027
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Trichomonas vaginalis reverse transcriptases, putative 0.0007 0.0041 0.0031
Toxoplasma gondii protein kinase, putative 0.0357 0.5316 1
Schistosoma mansoni glucose transport protein 0.0126 0.1839 0.2694
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0007 0.0041 0.0035
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0224 0.0304
Echinococcus multilocularis glycyl tRNA synthetase 0.0007 0.0041 0.0036
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0007 0.0041 0.0035
Schistosoma mansoni netrin receptor unc5 0.0017 0.0185 0.0266
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus granulosus General substrate transporter 0.0108 0.1571 0.2286
Echinococcus granulosus geminin 0.0175 0.2582 0.3772
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0093 0.1119
Schistosoma mansoni protein kinase 0.0039 0.0517 0.0754
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0007 0.0041 0.0024
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0517 0.0501
Schistosoma mansoni hypothetical protein 0.0009 0.0077 0.0108
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0007 0.0041 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0518 0.0597
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus granulosus ferritin 0.0009 0.0066 0.0073
Trypanosoma brucei glucose transporter, putative 0.0039 0.0525 0.1071
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.06 0.0748
Loa Loa (eye worm) sugar transporter 0.0018 0.0202 0.0185
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.3012 0.3724
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0224 0.072
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0525 0.868
Echinococcus granulosus death domain containing protein 0.0017 0.0185 0.0246
Schistosoma mansoni hypothetical protein 0.0175 0.2582 0.3784
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0038
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0518 0.0597
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.0009 0.0077 0.0108
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0009 0.0077 0.0088
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0517 0.0736
Brugia malayi hypothetical protein 0.0009 0.0071 0.0054
Echinococcus granulosus nuclear factor of activated T cells 5 0.0085 0.1217 0.1765
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0038
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0007 0.0041 0.0468
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1839 0.268
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1839 0.268
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0082 0.0065
Plasmodium falciparum protein kinase 6 0.0536 0.8019 1
Plasmodium falciparum protein kinase 7 0.0357 0.5316 0.6612
Loa Loa (eye worm) sugar transporter 0.0126 0.1839 0.1825
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0359 1
Trichomonas vaginalis rotamase, putative 0.0034 0.0444 0.1053
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2581 0.6479
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0224 0.0207
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0224 0.0207
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0007 0.0041 0.0024
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0505 0.0489
Loa Loa (eye worm) hypothetical protein 0.0019 0.0224 0.0207
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0359 0.6932
Onchocerca volvulus 0.0009 0.0071 0.0117
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.06 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0071 0.0054
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0071 0.0117
Brugia malayi Sugar transporter family protein 0.0018 0.0202 0.0185
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0169 0.0152
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.06 0.145
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0505 0.121
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0185 0.0246
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0071 0.0054
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0525 0.1071
Onchocerca volvulus 0.0019 0.0224 0.072
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.06 0.0748
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0444 0.0896
Echinococcus granulosus solute carrier family 22 0.0018 0.0202 0.0272
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0071 0.0079
Brugia malayi hypothetical protein 0.001 0.0087 0.007
Brugia malayi Cell death specification protein 2 0.0009 0.0077 0.006
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0224 0.0324
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0185 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0517 0.0754
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0456 0.044
Giardia lamblia Hypothetical protein 0.0009 0.0077 0.0706
Schistosoma mansoni sugar transporter 0.0018 0.0202 0.0291
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0038
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0257 0.3994
Brugia malayi nuclear hormone receptor 0.0019 0.0224 0.0207
Mycobacterium tuberculosis Possible maturase 0.0007 0.0041 0.0465
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0202 0.6499
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.006
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0202 0.0185
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0054 0.0054
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0007 0.0041 0.0031
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0224 0.0304
Trypanosoma brucei glucose transporter 2A 0.0039 0.0525 0.1071
Brugia malayi CXXC zinc finger family protein 0.0032 0.0417 0.0401
Brugia malayi Cell death specification protein 2 0.0009 0.0077 0.006
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0054 0.0054
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0359 0.0713
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0071 0.0054
Schistosoma mansoni transcription factor btf3 0.0036 0.048 0.07
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0224 0.0207
Onchocerca volvulus 0.0018 0.0202 0.0633
Loa Loa (eye worm) hypothetical protein 0.0038 0.0505 0.0489
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0224 0.0304
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0085 0.1217 0.1765
Toxoplasma gondii sugar transporter ST3 0.0018 0.0202 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0083 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3969 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.06 0.1081
Toxoplasma gondii glycyl-tRNA synthetase 0.0007 0.0041 0.0024
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0071 0.0054
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0481 0.0683
Brugia malayi bZIP transcription factor family protein 0.0009 0.0077 0.006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0398 0.0382
Brugia malayi hypothetical protein 0.0009 0.0077 0.006
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.06 0.1234
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0525 0.1259
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0224 0.072
Loa Loa (eye worm) acetyltransferase 0.015 0.2199 0.2185
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0444 0.7259
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0224 0.0207
Echinococcus multilocularis geminin 0.0175 0.2582 0.3772
Brugia malayi hypothetical protein 0.0009 0.0071 0.0054
Schistosoma mansoni zinc finger protein 0.0006 0.0017 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0202 0.0439
Trypanosoma brucei glucose transporter, putative 0.0039 0.0525 0.1071
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0066 0.1142
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0517 0.1055
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0202 0.0272
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0087 0.0103
Schistosoma mansoni glucose transport protein 0.0126 0.1839 0.2694
Plasmodium vivax glycine--tRNA ligase, putative 0.0007 0.0041 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0224 0.0207
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0077 0.0109
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0224 0.0304
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.048 0.8724
Trichomonas vaginalis helicase, putative 0.0007 0.0043 0.0038
Brugia malayi hypothetical protein 0.0009 0.0077 0.006
Brugia malayi conserved hypotetical protein 0.0009 0.0071 0.0054
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0071 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0224 0.0207
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0007 0.0041 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.048 0.1146
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1839 0.268
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0224 0.0304
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0011 0.0093 0.3205
Brugia malayi Zinc knuckle family protein 0.0007 0.0041 0.0024
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1839 0.268
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Trypanosoma brucei unspecified product 0.0007 0.0041 0.0027
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.3012 0.5643
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0224 0.0324
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0544 1
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0481 0.0683
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus multilocularis transcription factor btf3 0.0036 0.048 0.0681
Loa Loa (eye worm) hypothetical protein 0.0019 0.0224 0.0207
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0087 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.048 0.1146
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.06 0.145
Schistosoma mansoni apoferritin-2 0.0009 0.0066 0.0093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0224 0.0207
Leishmania major threonyl-tRNA synthetase, putative 0.0007 0.0041 0.0218
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0517 0.0736
Schistosoma mansoni hypothetical protein 0.0126 0.1839 0.2694
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.0009 0.0077 0.0088
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0359 0.0399
Echinococcus granulosus dnaJ subfamily B 0.0456 0.6816 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0041 0.0027
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0007 0.0041 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0038
Echinococcus multilocularis solute carrier family 22 0.0018 0.0202 0.0272
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0009 0.0077 0.0088
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.06 0.108
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0224 0.0207
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0224 0.0207
Echinococcus multilocularis Ankyrin 0.0017 0.0187 0.0249
Brugia malayi nuclear receptor NHR-67 0.0009 0.0071 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0525 0.1259
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0202 0.0185
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2581 0.6479
Brugia malayi hypothetical protein 0.0007 0.0041 0.0024
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1839 0.268
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.048 0.0599
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.048 0.0975
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0202 0.0439
Schistosoma mansoni hypothetical protein 0.0017 0.0185 0.0266
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.2581 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0224 0.0207
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0071 0.0117
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Trichomonas vaginalis reverse transcriptases, putative 0.0007 0.0041 0.0031
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0359 0.0343
Toxoplasma gondii sugar transporter ST1 0.0018 0.0202 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0517 0.0736
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0202 0.303
Onchocerca volvulus 0.0018 0.0202 0.0633
Loa Loa (eye worm) DR-78 0.0009 0.0071 0.0054
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0071 0.0099
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0359 0.0839
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0202 0.0439
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0071 0.0079
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0444 0.7259
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0517 0.124
Schistosoma mansoni hypothetical protein 0.0456 0.6816 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Trypanosoma brucei RNA helicase, putative 0.0313 0.4662 1
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0071 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.048 0.1146
Schistosoma mansoni apoferritin-2 0.0009 0.0066 0.0093
Brugia malayi nuclear receptor RXR 0.0009 0.0071 0.0054
Leishmania major glucose transporter, lmgt2 0.0039 0.0525 0.868
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0071 0.0079
Brugia malayi Death domain containing protein 0.0017 0.0185 0.0168
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Schistosoma mansoni protein kinase 0.0007 0.0041 0.0055
Brugia malayi nuclear receptor RXR 0.001 0.0087 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0041 0.0217
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0544 0.0631
Echinococcus multilocularis solute carrier family 22 0.0018 0.0202 0.0272
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0007 0.0041 0.0024
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0071 0.0054
Onchocerca volvulus 0.0009 0.0071 0.0117
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Brugia malayi hypothetical protein 0.001 0.0087 0.007
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.06 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Loa Loa (eye worm) hypothetical protein 0.0007 0.0041 0.0024
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0202 0.0439
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Schistosoma mansoni protein kinase 0.0039 0.0517 0.0754
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0359 0.5783
Schistosoma mansoni bromodomain containing protein 0.0006 0.0017 0.002
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0007 0.0041 0.0035
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0066 0.0792
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0518 0.0925
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0456 0.044
Schistosoma mansoni zinc finger protein 0.0009 0.0071 0.0099
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0224 0.0324
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0224 0.0207
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0007 0.0041 0.0032
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0444 0.7259
Entamoeba histolytica hypothetical protein 0.0036 0.048 0.8724
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0007 0.0041 0.0027
Echinococcus multilocularis solute carrier family 22 0.0018 0.0202 0.0272
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0359 0.0448
Trypanosoma brucei ingi protein (ORF1) 0.0007 0.0041 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0043 0.0038
Brugia malayi Uncoordinated protein 44 0.0017 0.0185 0.0168
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Giardia lamblia Sugar-proton symporter 0.0018 0.0202 0.3194
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0202 0.6499
Brugia malayi Sugar transporter family protein 0.0126 0.1839 0.1825
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.048 0.7901
Schistosoma mansoni hypothetical protein 0.0007 0.0041 0.0055
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0444 0.0785
Brugia malayi reverse transcriptase 0.0007 0.0041 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Schistosoma mansoni cpg binding protein 0.0034 0.0445 0.0648
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0505 0.0718
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0224 0.0304
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus granulosus solute carrier family 22 0.0018 0.0202 0.0272
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0518 0.0597
Loa Loa (eye worm) hypothetical protein 0.0017 0.0185 0.0168
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0007 0.0041 0.0035
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.06 0.0857
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0054 0.0054
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0224 0.0324
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.007
Loa Loa (eye worm) ICD-1 protein 0.0036 0.048 0.0464
Giardia lamblia Hexose transporter 0.0018 0.0202 0.3194
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0224 0.0304
Echinococcus multilocularis X box binding protein 1 0.0298 0.4435 0.6498
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0224 0.0324
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.048 0.055
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0071 0.0054
Loa Loa (eye worm) hypothetical protein 0.0667 1 1
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0202 0.0327
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0359 0.0503
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.2724 0.684
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0224 0.0304
Giardia lamblia Threonyl-tRNA synthetase 0.0007 0.0041 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0224 0.0324
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0093 0.0138
Brugia malayi nuclear receptor NHR-88 0.0019 0.0224 0.0207
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0054 0.0054
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0093 0.1119
Leishmania major glucose transporter, lmgt3 0.0039 0.0525 0.868
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0359 0.0625
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0224 0.0304
Loa Loa (eye worm) hypothetical protein 0.0017 0.0187 0.017
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus granulosus transcription factor btf3 0.0036 0.048 0.0681
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0518 0.0597
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0007 0.0041 0.0377
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0136 0.3243
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0087 0.007
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.06 0.108
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0007 0.0041 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0224 0.0207
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3969 1
Brugia malayi hypothetical protein 0.0007 0.0041 0.0024
Onchocerca volvulus 0.0018 0.0202 0.0633
Echinococcus multilocularis expressed protein 0.0035 0.0456 0.0645
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0071 0.0079
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0224 0.072
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0066 0.1142
Mycobacterium ulcerans sugar transporter 0.0018 0.0202 0.5239
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0007 0.0041 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Onchocerca volvulus 0.0018 0.0202 0.0633
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0518 0.0925
Brugia malayi Cell death specification protein 2 0.0009 0.0077 0.006
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0517 0.0501
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0224 0.0324
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.3012 0.3756
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3969 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0224 0.0207
Schistosoma mansoni hypothetical protein 0.0009 0.0077 0.0108
Brugia malayi Cam kinase protein 1 0.0039 0.0517 0.0501
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0224 0.0207
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0041 0.0218
Brugia malayi beta-NAC-like protein 0.0036 0.048 0.0464
Brugia malayi major facilitator superfamily protein 0.0018 0.0202 0.0185
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.06 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0525 0.1071
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0007 0.0041 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.0038
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0071 0.0054
Loa Loa (eye worm) hypothetical protein 0.0039 0.0517 0.0501
Brugia malayi Sugar transporter family protein 0.0018 0.0202 0.0185
Entamoeba histolytica protein kinase, putative 0.0039 0.0517 0.9461
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Brugia malayi nuclear hormone receptor 0.0009 0.0071 0.0054
Brugia malayi reverse transcriptase 0.0007 0.0041 0.0024
Leishmania major hypothetical protein, conserved 0.0018 0.0202 0.303
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus granulosus expressed protein 0.0035 0.0456 0.0645
Brugia malayi nuclear receptor NHR-88 0.0009 0.0071 0.0054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0224 0.0207
Onchocerca volvulus 0.0018 0.0202 0.0633
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0359 0.0503
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0224 0.0304
Loa Loa (eye worm) hypothetical protein 0.0019 0.0224 0.0207
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0071 0.0099
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2581 0.6479
Onchocerca volvulus 0.0018 0.0202 0.0633
Brugia malayi steroid hormone receptor 0.0019 0.0224 0.0207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.0038
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0185 0.0168
Schistosoma mansoni rotamase 0.0035 0.0456 0.0664
Echinococcus granulosus expressed protein 0.0009 0.0066 0.0073
Echinococcus granulosus X box binding protein 1 0.0298 0.4435 0.6498
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0009 0.0077 0.0088
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0224 0.0304
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0202 0.0291
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0185 0.0246
Onchocerca volvulus 0.0018 0.0202 0.0633
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0087 0.0123
Loa Loa (eye worm) hypothetical protein 0.0028 0.0359 0.0343
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0083 0.0098
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0959 0.1403
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.2199 0.3222
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.3969 0.3959
Schistosoma mansoni hypothetical protein 0.0313 0.4662 0.6837
Trypanosoma brucei sugar transporter, putative 0.0018 0.0202 0.0374
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0518 0.0645
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.0009 0.0077 0.0088
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0224 0.0304
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0505 0.9226
Schistosoma mansoni ferritin 0.0009 0.0066 0.0093
Schistosoma mansoni glucose transporter 0.0018 0.0202 0.0291
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0224 0.0304
Brugia malayi glycyl-tRNA synthetase 0.0007 0.0041 0.0024
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0007 0.0041 0.0027
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0071 0.0079
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.3969 0.3959
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0905 0.1657
Schistosoma mansoni sugar transporter 0.0018 0.0202 0.0291
Brugia malayi hypothetical protein 0.0018 0.0202 0.0185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0224 0.0207
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0517 0.0501
Loa Loa (eye worm) cell death specification protein 2 0.0009 0.0077 0.006
Echinococcus multilocularis General substrate transporter 0.0108 0.1571 0.2286
Schistosoma mansoni nuclear receptor 0.0009 0.0071 0.0099
Onchocerca volvulus 0.0018 0.0202 0.0633
Plasmodium vivax sugar transporter, putative 0.0018 0.0202 0.0252
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0525 0.868
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3969 1
Echinococcus multilocularis solute carrier family 22 0.0018 0.0202 0.0272
Schistosoma mansoni nuclear receptor 0.0009 0.0071 0.0099
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0202 0.303
Brugia malayi hypothetical protein 0.0007 0.0041 0.0024
Trypanosoma brucei glucose transporter 1E 0.0039 0.0525 0.1071
Schistosoma mansoni bromodomain containing protein 0.0006 0.0017 0.002
Loa Loa (eye worm) bZIP transcription factor family protein 0.0009 0.0077 0.006
Leishmania major protein kinase, putative 0.0039 0.0517 0.855
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0525 0.1259
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0525 0.1259
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0525 0.868
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0525 0.1071
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0518 0.0645
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0185 0.0565
Trichomonas vaginalis ferritin, putative 0.0009 0.0066 0.0096
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0185 0.0246
Toxoplasma gondii sugar transporter ST2 0.0018 0.0202 0.0327
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0185 0.0266
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Schistosoma mansoni glycyl-tRNA synthetase 0.0007 0.0041 0.0056
Echinococcus multilocularis protocadherin 11 0.0009 0.0077 0.0088
Brugia malayi hypothetical protein 0.0018 0.0202 0.0185
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Loa Loa (eye worm) hypothetical protein 0.0009 0.0071 0.0054
Schistosoma mansoni ferritin 0.0009 0.0066 0.0093
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0202 0.0439
Plasmodium vivax hexose transporter 0.0126 0.1839 0.2293
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0202 0.0439
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0202 0.0272
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0071 0.0099
Echinococcus granulosus protocadherin 11 0.0009 0.0077 0.0088
Schistosoma mansoni ferritin light chain 0.0009 0.0066 0.0093
Trypanosoma brucei glucose transporter, putative 0.0039 0.0525 0.1071
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0224 0.0304
Schistosoma mansoni ferritin light chain 0.0009 0.0066 0.0093
Brugia malayi Pao retrotransposon peptidase family protein 0.0007 0.0041 0.0024
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0505 0.0737
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0505 0.0718
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0224 0.0304
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0202 0.0185
Echinococcus multilocularis cpg binding protein 0.0034 0.0445 0.0629
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0093 0.0121
Entamoeba histolytica protein kinase, putative 0.0039 0.0517 0.9461
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0202 0.5239
Onchocerca volvulus 0.0032 0.0417 0.1481
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1839 0.268
Schistosoma mansoni sugar transporter 0.0018 0.0202 0.0291
Echinococcus granulosus Ankyrin 0.0017 0.0187 0.0249
Echinococcus granulosus protocadherin 11 0.0009 0.0077 0.0088
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0007 0.0041 0.0055
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0066 0.1417
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0224 0.0207
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0518 0.0645
Entamoeba histolytica hypothetical protein 0.0028 0.0359 0.6319
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0071 0.0079
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0295 1
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0224 0.0207
Onchocerca volvulus 0.0009 0.0077 0.014
Echinococcus multilocularis protocadherin 11 0.0009 0.0077 0.0088
Schistosoma mansoni hypothetical protein 0.0007 0.0041 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0224 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0224 0.0207
Onchocerca volvulus 0.0018 0.0202 0.0633
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0224 0.0207
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.006
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0224 0.0304
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0517 0.0736
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.0185
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0359 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0224 0.0207
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.007
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0202 0.0185
Schistosoma mansoni par domain protein 0.0009 0.0077 0.0108
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0043 0.0038
Echinococcus multilocularis expressed protein 0.0009 0.0066 0.0073
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0041 0.0218
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0517 0.0736
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0202 0.5239
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.1839 0.268
Schistosoma mansoni cpg binding protein 0.0034 0.0445 0.0648
Echinococcus granulosus ccaat enhancer binding protein delta 0.0009 0.0077 0.0088
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.2135 0.3115
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0505 0.0489
Trypanosoma brucei glucose transporter, putative 0.0039 0.0525 0.1071
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.007
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0359 0.632

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 294 nM MMV: Inhibition of Plasmodium falciparum K1 (EC50). ChEMBL. No reference
EC50 (functional) = 735 nM MMV: Inhibition of Plasmodium falciparum 3D7 (EC50). ChEMBL. No reference
EC50 (functional) 1.0568 uM ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) = 1.06 uM Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) = 5.21 uM Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) 5.2107 uM ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
Growth Inhibition (functional) = 25.9468 % MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. ChEMBL. No reference
IC50 (functional) = 850.7 nM MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) = 5.38360071182251 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 (functional) = 11.0160760879517 uM MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). ChEMBL. No reference
IC50 (functional) = 13.189440727233887 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) = 13.1894407272339 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) = 15.7554359436035 uM MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). ChEMBL. No reference
IC50 (functional) > 30 uM MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. ChEMBL. No reference
IC50 > 32 uM MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. ChEMBL. No reference
Inhibition (functional) = -29.2859959962464 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -14.6169412876055 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -11.7908026539 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -11.790802653899977 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -0.405376976886443 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = -0.4053769768864429 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = 16 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 22.3 % MMV: Screen against Mtb, single point, non replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 24 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 90.5 % MMV: Screen against Mtb, single point, replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 96 % MMV: Inhibition of Plasmodium falciparum 3D7 at 5uM compound concentration. ChEMBL. No reference
MIC90 (functional) = 37.5 uM MMV: CRC and MIC90 against Mtb (replicating) ChEMBL. No reference
MIC90 (functional) > 100 uM MMV: CRC and MIC90 against Mtb (non replicating) ChEMBL. No reference
Percent growth inhibition (functional) = 85.2 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye Saint Jude. 20485428
Percent growth inhibition (functional) = 91.1 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye Saint Jude. 20485428
Ratio (functional) = 0.950819672131147 MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. ChEMBL. No reference
Relative Growth (functional) = -0.013 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = 0.0043 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = 0.0536 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 20485428
Trypanosoma cruzi ChEMBL23
Leishmania infantum ChEMBL23
Trypanosoma brucei gambiense

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

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