Detailed information for compound 934843

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 287.249 | Formula: C12H18NO5P
  • H donors: 3 H acceptors: 5 LogP: -0.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)CCCC(P(=O)(O)O)c1ccccc1)O
  • InChi: 1S/C12H18NO5P/c1-13(15)12(14)9-5-8-11(19(16,17)18)10-6-3-2-4-7-10/h2-4,6-7,11,15H,5,8-9H2,1H3,(H2,16,17,18)
  • InChiKey: BJAJYJPPRQEDDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli 1-deoxy-D-xylulose 5-phosphate reductoisomerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis 1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium knowlesi 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Theileria parva 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium berghei 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Neospora caninum 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium yoelii 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras Get druggable targets OG5_130462 All targets in OG5_130462
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.1378 0.2961
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.1378 0.2961
Brugia malayi conserved hypotetical protein 0.0014 0.004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.019 0.0159
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0363 0.0345
Echinococcus granulosus tar DNA binding protein 0.0326 0.2929 0.6339
Onchocerca volvulus 0.0109 0.0917 0.4143
Echinococcus multilocularis G-protein coupled receptor, putative 0.0159 0.1378 0.1834
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0917 0.2866
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.004 0.0055
Brugia malayi ecdysone receptor 0.0014 0.004 0.0008
Brugia malayi hypothetical protein 0.0159 0.1378 0.1351
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0031 0.0068
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0795 0.1058
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0199 0.0402
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1088 1 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0031 0.0012
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0395 0.0365
Echinococcus granulosus alpha 1A adrenergic receptor 0.0159 0.1378 0.2983
Onchocerca volvulus 0.0159 0.1378 0.6322
Entamoeba histolytica hypothetical protein 0.0074 0.059 1
Brugia malayi hypothetical protein 0.0026 0.0148 0.0117
Loa Loa (eye worm) hypothetical protein 0.0229 0.2032 0.2016
Loa Loa (eye worm) hypothetical protein 0.0109 0.0917 0.0899
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0037 0.0247 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.019 0.0171
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.4726 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0005
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0031 0.0042
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0159 0.1378 0.2961
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Loa Loa (eye worm) cytochrome P450 0.0037 0.0247 0.0228
Brugia malayi RNA recognition motif domain containing protein 0.0326 0.2929 0.2906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.019 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.019 0.0159
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1202 0.1599
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.004 0.002
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0335 0.0726
Echinococcus granulosus cpg binding protein 0.0062 0.0483 0.1046
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.1378 0.2983
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0053 0.007
Plasmodium vivax SET domain protein, putative 0.0032 0.0199 0.0314
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Brugia malayi Serotonin receptor 0.0159 0.1378 0.1351
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.004 0.0053
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0159 0.1378 0.1834
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0363 0.108
Echinococcus multilocularis neuropeptide receptor 0.0159 0.1378 0.1834
Schistosoma mansoni glutaminase 0.0271 0.242 0.5223
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0014 0.0031 0.0012
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Brugia malayi G protein-coupled receptor F59B2.13 0.0159 0.1378 0.1351
Echinococcus multilocularis neuropeptides capa receptor 0.0159 0.1378 0.1834
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Brugia malayi nuclear hormone receptor 0.0014 0.004 0.0008
Loa Loa (eye worm) neuropeptide F receptor 0.0159 0.1378 0.1361
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0056 0.0121
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0159 0.1378 0.1834
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Loa Loa (eye worm) hypothetical protein 0.0109 0.0917 0.0899
Brugia malayi Cytochrome P450 family protein 0.0055 0.0416 0.0386
Schistosoma mansoni amine GPCR 0.0159 0.1378 0.2961
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0037 0.0247 0.2253
Onchocerca volvulus 0.0159 0.1378 0.6322
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.1378 0.2983
Brugia malayi nuclear receptor RXR 0.0016 0.0056 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0199 0.0402
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus multilocularis allatostatin A receptor 0.0159 0.1378 0.1834
Brugia malayi glutaminase DH11.1 0.0271 0.242 0.2396
Brugia malayi hypothetical protein 0.0159 0.1378 0.1351
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0363 0.108
Onchocerca volvulus 0.0159 0.1378 0.6322
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0159 0.1378 0.2961
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Schistosoma mansoni neuropeptide receptor 0.0159 0.1378 0.2961
Loa Loa (eye worm) glutaminase 2 0.0271 0.242 0.2405
Echinococcus granulosus 7tm_1 domain containing protein 0.0159 0.1378 0.2983
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0101 0.0839 0.1817
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0917 0.1368
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0482 0.068
Onchocerca volvulus 0.0027 0.0151 0.0527
Schistosoma mansoni amine GPCR 0.0159 0.1378 0.2961
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.4726 1
Loa Loa (eye worm) hypothetical protein 0.0357 0.3216 0.3203
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.1378 0.2983
Echinococcus granulosus g protein coupled receptor 0.0159 0.1378 0.2983
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.019 0.0382
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.1378 0.1834
Trichomonas vaginalis inositol monophosphatase, putative 0.0072 0.0576 0.1766
Schistosoma mansoni intermediate filament proteins 0.0027 0.0151 0.0297
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0148 0.1107
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.004 0.0053
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Onchocerca volvulus 0.0159 0.1378 0.6322
Onchocerca volvulus 0.0109 0.0917 0.4143
Schistosoma mansoni hypothetical protein 0.0508 0.462 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0159 0.1378 0.1361
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0576 0.6057
Schistosoma mansoni neuropeptide receptor 0.0159 0.1378 0.2961
Schistosoma mansoni hypothetical protein 0.0037 0.0247 0.0506
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0085 0.0065
Brugia malayi GnHR receptor homolog 0.0159 0.1378 0.1351
Echinococcus multilocularis fmrfamide receptor 0.0159 0.1378 0.1834
Schistosoma mansoni lamin 0.0027 0.0151 0.0297
Brugia malayi Pre-SET motif family protein 0.0213 0.1885 0.1859
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0917 0.1368
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.7516 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0159 0.1378 0.2983
Brugia malayi nuclear hormone receptor 0.0031 0.019 0.0159
Brugia malayi Inositol-1 0.0072 0.0576 0.0546
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0363 0.3598
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0199 0.0265
Schistosoma mansoni biogenic amine receptor 0.0159 0.1378 0.2961
Echinococcus granulosus serotonin receptor 0.0159 0.1378 0.2983
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0917 0.1368
Trichomonas vaginalis esterase, putative 0.0109 0.0917 0.2866
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.1075 0.2303
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.019 0.0159
Brugia malayi G-protein coupled receptor 0.0159 0.1378 0.1351
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.004 0.0086
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0159 0.1378 0.1351
Trypanosoma brucei protein kinase, putative 0.0049 0.0363 0.3598
Schistosoma mansoni biogenic amine receptor 0.0159 0.1378 0.2961
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.3126 1
Brugia malayi Serotonin receptor 0.0159 0.1378 0.1351
Brugia malayi hypothetical protein 0.0229 0.2032 0.2007
Echinococcus granulosus geminin 0.0508 0.462 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0335 0.1398
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0482 0.0641
Schistosoma mansoni nuclear receptor 0.0014 0.004 0.0055
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.004 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.019 0.0159
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0839 0.1791
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0917 0.2866
Schistosoma mansoni neuropeptide F-like receptor 0.0159 0.1378 0.2961
Brugia malayi Dopamine receptor 0.0159 0.1378 0.1351
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0101 0.0839 0.1117
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0031 0.0007
Loa Loa (eye worm) beta-lactamase 0.0109 0.0917 0.0899
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0012
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0148 0.0205
Mycobacterium ulcerans beta-lactamase 0.0109 0.0917 0.1495
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0037 0.0247 0.0308
Loa Loa (eye worm) hypothetical protein 0.0026 0.0147 0.0127
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0037 0.0247 0.0308
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0037 0.0247 0.0308
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0031 0.0037
Brugia malayi mbt repeat family protein 0.0046 0.0335 0.0305
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0031 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0037 0.0247 0.0308
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0037 0.0247 0.0308
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0037 0.0247 0.0308
Brugia malayi AKH receptor 0.0159 0.1378 0.1351
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.019 0.0159
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0056 0.0036
Loa Loa (eye worm) hypothetical protein 0.0109 0.0917 0.0899
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0839 0.1791
Brugia malayi steroid hormone receptor 0.0031 0.019 0.0159
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0795 0.1721
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0037 0.0018
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.019 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.019 0.0159
Leishmania major cytochrome p450-like protein 0.0037 0.0247 0.2253
Echinococcus granulosus tm gpcr rhodopsin 0.0159 0.1378 0.2983
Schistosoma mansoni neuropeptide receptor 0.0159 0.1378 0.2961
Brugia malayi Nuclear hormone receptor E75 0.0014 0.004 0.0008
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 0.1378 0.2961
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Loa Loa (eye worm) hypothetical protein 0.0303 0.2717 0.2703
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0072 0.0576 0.1148
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1031 0.1013
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0199 0.0265
Trichomonas vaginalis set domain proteins, putative 0.0243 0.2157 0.687
Loa Loa (eye worm) melatonin receptor type 1A 0.0159 0.1378 0.1361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.019 0.0171
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0363 0.0484
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0363 0.0484
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0151 0.0132
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0521 0.0491
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0303 0.2717 0.2703
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0031 0.0068
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0363 0.0787
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0148 0.0205
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0072 0.0576 0.0734
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.1552 0.7142
Brugia malayi Cytochrome P450 family protein 0.0116 0.0985 0.0956
Schistosoma mansoni hypothetical protein 0.0159 0.1378 0.2961
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0917 0.1495
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0576 0.1766
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.019 0.0382
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.019 0.0253
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0031 0.0007
Echinococcus granulosus g protein coupled receptor 0.0159 0.1378 0.2983
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.019 0.0159
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.4726 0.5
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.4726 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0482 0.0524
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0363 0.3598
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.019 0.0711
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0917 1
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0917 0.2866
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0037 0.0247 0.0308
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0521 0.1127
Schistosoma mansoni neuropeptide f receptor 76f 0.0159 0.1378 0.2961
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.019 0.0411
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Toxoplasma gondii melibiase subfamily protein 0.0101 0.0839 0.171
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0363 0.0787
Echinococcus granulosus sex peptide receptor 0.0159 0.1378 0.2983
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0917 0.1959
Schistosoma mansoni alpha-1 adrenergic receptor 0.0159 0.1378 0.2961
Schistosoma mansoni hypothetical protein 0.0159 0.1378 0.2961
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0482 0.0524
Echinococcus granulosus somatostatin receptor 0.0159 0.1378 0.2983
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0326 0.2929 0.2915
Brugia malayi hypothetical protein 0.0159 0.1378 0.1351
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0159 0.1378 0.2961
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0085 0.0183
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.019 0.0159
Onchocerca volvulus 0.0159 0.1378 0.6322
Brugia malayi RNA binding protein 0.0326 0.2929 0.2906
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.004 0.0086
Loa Loa (eye worm) TAR-binding protein 0.0326 0.2929 0.2915
Loa Loa (eye worm) hypothetical protein 0.0031 0.019 0.0171
Brugia malayi Melatonin receptor type 1A 0.0159 0.1378 0.1351
Schistosoma mansoni growth hormone secretagogue receptor 0.0159 0.1378 0.2961
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.019 0.0159
Echinococcus multilocularis serotonin receptor 0.0159 0.1378 0.1834
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.019 0.0253
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0037 0.0247 0.0308
Onchocerca volvulus 0.0047 0.0339 0.1414
Entamoeba histolytica hypothetical protein 0.0074 0.059 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0151 0.0327
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.004 0.0086
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.004 0.0008
Loa Loa (eye worm) DR-78 0.0014 0.004 0.002
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0363 0.108
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0335 0.0446
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0037 0.0247 0.0308
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0051 0.0081
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0357 0.3216 0.3195
Brugia malayi MAP kinase sur-1 0.0049 0.0363 0.0333
Onchocerca volvulus 0.0159 0.1378 0.6322
Loa Loa (eye worm) hypothetical protein 0.0109 0.0917 0.0899
Brugia malayi hypothetical protein 0.0014 0.004 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0031 0.019 0.0382
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0159 0.1378 0.1834
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0014 0.0019
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0576 0.6057
Schistosoma mansoni cpg binding protein 0.0059 0.0452 0.095
Schistosoma mansoni neuropeptide F-like receptor 0.0159 0.1378 0.2961
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus multilocularis neuropeptide Y receptor 0.0159 0.1378 0.1834
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0917 0.2866
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0159 0.1378 0.2961
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.019 0.0411
Schistosoma mansoni tar DNA-binding protein 0.0326 0.2929 0.6328
Schistosoma mansoni nuclear hormone receptor 0.0014 0.004 0.0055
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0031 0.0042
Brugia malayi latrophilin 2 splice variant baaae 0.0207 0.1828 0.1802
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.004 0.0053
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0917 0.2866
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.019 0.0159
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0037 0.0006
Brugia malayi isocitrate dehydrogenase 0.0016 0.0053 0.0021
Brugia malayi Cytochrome P450 family protein 0.0055 0.0416 0.0386
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0199 0.0432
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0521 0.5417
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0159 0.1378 0.2961
Loa Loa (eye worm) hypothetical protein 0.0109 0.0917 0.0899
Onchocerca volvulus 0.0159 0.1378 0.6322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1202 0.2579
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.004 0.0055
Onchocerca volvulus 0.0243 0.2157 1
Echinococcus granulosus neuropeptides capa receptor 0.0159 0.1378 0.2983
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0055
Echinococcus granulosus neuropeptide receptor A26 0.0159 0.1378 0.2983
Echinococcus multilocularis g protein coupled receptor 0.0159 0.1378 0.1834
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0159 0.1378 0.6322
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0521 0.5417
Echinococcus granulosus tm gpcr rhodopsin 0.0159 0.1378 0.2983
Loa Loa (eye worm) G-protein coupled receptor 0.0159 0.1378 0.1361
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0031 0.0042
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0159 0.1378 0.1351
Mycobacterium tuberculosis Conserved protein 0.0109 0.0917 0.1368
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.004 0.0053
Echinococcus granulosus hypothetical protein 0.0159 0.1378 0.2983
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0917 0.1495
Echinococcus multilocularis geminin 0.0508 0.462 0.6147
Brugia malayi neuropeptide F receptor 0.0159 0.1378 0.1351
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0159 0.1378 0.1361
Schistosoma mansoni tar DNA-binding protein 0.0326 0.2929 0.6328
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0159 0.1378 0.2961
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1202 0.2602
Schistosoma mansoni amine GPCR 0.0159 0.1378 0.2961
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0056 0.0024
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Echinococcus granulosus fmrfamide receptor 0.0159 0.1378 0.2983
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.004 0.002
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0053 0.0032
Loa Loa (eye worm) hypothetical protein 0.0031 0.019 0.0171
Brugia malayi neuropeptide F receptor 0.0159 0.1378 0.1351
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0037 0.0247 0.0308
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0159 0.1378 0.2961
Onchocerca volvulus 0.0031 0.019 0.0711
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.019 0.0171
Brugia malayi G-protein coupled receptor 0.0159 0.1378 0.1351
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.1378 0.1834
Schistosoma mansoni nuclear hormone receptor 0.0014 0.004 0.0055
Echinococcus granulosus tm gpcr rhodopsin 0.0159 0.1378 0.2983
Brugia malayi hypothetical protein 0.0014 0.004 0.0008
Onchocerca volvulus 0.0159 0.1378 0.6322
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0037 0.0247 0.0308
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.004 0.0055
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0159 0.1378 0.1834
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.1378 0.2961
Onchocerca volvulus 0.0159 0.1378 0.6322
Echinococcus multilocularis fmrfamide receptor 0.0159 0.1378 0.1834
Loa Loa (eye worm) neuropeptide F receptor 0.0159 0.1378 0.1361
Echinococcus multilocularis lamin dm0 0.0027 0.0151 0.0201
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0037 0.0247 0.0308
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0036
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Leishmania major cytochrome p450-like protein 0.0037 0.0247 0.2253
Schistosoma mansoni lamin 0.0027 0.0151 0.0297
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0159 0.1378 0.2983
Schistosoma mansoni hypothetical protein 0.0508 0.462 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0335 0.0317
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.004 0.0053
Toxoplasma gondii ABC1 family protein 0.0109 0.0917 0.1875
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.019 0.0382
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0521 0.0502
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0795 0.1058
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0151 0.012
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0031 0.0037
Leishmania major cytochrome p450-like protein 0.0055 0.0416 0.4212
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0335 0.0698
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0051 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.1378 0.2983
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0521 0.11
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.052 0.4726 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.1378 0.2961
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1202 0.1599
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0335 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.1378 0.1834
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0037 0.0247 0.0308
Brugia malayi mbt repeat family protein 0.0046 0.0335 0.0305
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0839 0.1791
Echinococcus multilocularis g protein coupled receptor 0.0159 0.1378 0.1834
Mycobacterium leprae Probable lipase LipE 0.0109 0.0917 0.1495
Entamoeba histolytica hypothetical protein 0.0074 0.059 1
Leishmania major hypothetical protein, conserved 0.0026 0.0148 0.1107
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0482 0.4969
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0159 0.1378 0.1834
Echinococcus multilocularis 0.0037 0.0247 0.0329
Echinococcus granulosus FTZ F1 alpha 0.0031 0.019 0.0411
Echinococcus multilocularis neuropeptide s receptor 0.0159 0.1378 0.1834
Loa Loa (eye worm) hypothetical protein 0.0177 0.1552 0.1535
Echinococcus granulosus allatostatin A receptor 0.0159 0.1378 0.2983
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0031 0.0012
Schistosoma mansoni hypothetical protein 0.0159 0.1378 0.2961
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0335 0.0698
Echinococcus granulosus neuropeptides capa receptor 0.0159 0.1378 0.2983
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0159 0.1378 0.2961
Echinococcus multilocularis serotonin receptor 0.0159 0.1378 0.1834
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.004 0.0086
Echinococcus granulosus neuropeptide s receptor 0.0159 0.1378 0.2983
Echinococcus multilocularis lamin 0.0027 0.0151 0.0201
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0363 0.3598
Onchocerca volvulus Neuropeptide F receptor homolog 0.0159 0.1378 0.6322
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.019 0.0382
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2032 0.2703
Echinococcus multilocularis somatostatin receptor 0.0159 0.1378 0.1834
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.019 0.0711
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0795 0.1721
Echinococcus multilocularis neuropeptide FF receptor 2 0.0159 0.1378 0.1834
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0159 0.1378 0.2983
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0159 0.1378 0.2961
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0037 0.0247 0.2253
Schistosoma mansoni nuclear receptor 0.0014 0.004 0.0055
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.019 0.0411
Brugia malayi hypothetical protein 0.0074 0.059 0.056
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.019 0.0382
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.018
Mycobacterium ulcerans glutaminase 0.0271 0.242 0.4851
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0031 0.0037
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0917 0.1368
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0151 0.0132
Echinococcus granulosus neuropeptide Y receptor 0.0159 0.1378 0.2983
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0037 0.0247 0.2253
Schistosoma mansoni cpg binding protein 0.0062 0.0483 0.1018
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0148 0.1107
Brugia malayi hypothetical protein 0.0159 0.1378 0.1351
Echinococcus granulosus g protein coupled receptor 0.0159 0.1378 0.2983
Brugia malayi sulfakinin receptor protein 0.0159 0.1378 0.1351
Schistosoma mansoni hypothetical protein 0.0047 0.0339 0.0705
Schistosoma mansoni coup transcription factor 0.0031 0.019 0.0382
Onchocerca volvulus 0.0046 0.0335 0.1398
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0917 0.1984
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0363 0.3598
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.019 0.0159
Onchocerca volvulus 0.0159 0.1378 0.6322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1202 0.2579
Loa Loa (eye worm) hypothetical protein 0.0031 0.019 0.0171
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.004 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.1378 0.2961
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0159 0.1378 0.2961
Echinococcus granulosus dro:myosuppressin receptor 0.0159 0.1378 0.2983
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0159 0.1378 0.1361
Trypanosoma brucei cytochrome P450, putative 0.0055 0.0416 0.4212
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.019 0.0171
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0056 0.0074
Mycobacterium ulcerans lipase LipD 0.0109 0.0917 0.1495
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0159 0.1378 0.1834
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0159 0.1378 0.2961
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.004 0.0086
Echinococcus multilocularis sex peptide receptor 0.0159 0.1378 0.1834
Brugia malayi TAR-binding protein 0.0326 0.2929 0.2906
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0395 0.0827
Mycobacterium tuberculosis Conserved protein 0.0109 0.0917 0.1368
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0159 0.1378 0.1834
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0521 0.5417
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0261 0.0566
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0037 0.0247 0.0308
Onchocerca volvulus 0.0159 0.1378 0.6322
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0031 0.0037
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.059 0.1277
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.019 0.0253
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0363 0.3598
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0395 0.0526
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.1378 0.1834
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0416 0.0398
Onchocerca volvulus 0.0159 0.1378 0.6322
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0159 0.1378 0.1834
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.019 0.0711
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0148 0.0236
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1031 0.1013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0339 0.0309
Echinococcus multilocularis tar DNA binding protein 0.0326 0.2929 0.3897
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0482 0.0948
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0917 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0917 0.0899
Loa Loa (eye worm) inositol-1 0.0072 0.0576 0.0558
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0363 0.0758
Echinococcus multilocularis cpg binding protein 0.0062 0.0483 0.0643
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.1378 0.2961
Onchocerca volvulus 0.0159 0.1378 0.6322
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0037 0.0247 0.0308
Brugia malayi Nuclear hormone receptor E75 0.0014 0.004 0.0008
Brugia malayi intermediate filament protein 0.0027 0.0151 0.012
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.004 0.0008
Brugia malayi hypothetical protein 0.0016 0.0056 0.0024
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0795 0.0766
Loa Loa (eye worm) hypothetical protein 0.0096 0.0795 0.0777
Echinococcus granulosus lamin dm0 0.0027 0.0151 0.0327
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0037 0.0247 0.0308
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0037 0.0247 0.0308
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0159 0.1378 0.2961
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.004 0.0053
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0576 0.1766
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.4726 1
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0917 0.1368
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0085 0.0113
Schistosoma mansoni cytochrome P450 0.0037 0.0247 0.0506
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0125 0.1065 0.1603
Onchocerca volvulus 0.0159 0.1378 0.6322
Brugia malayi hypothetical protein 0.0159 0.1378 0.1351
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0051 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.019 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.019 0.0171
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0037 0.0247 0.2253
Echinococcus granulosus neuropeptide Y receptor 0.0159 0.1378 0.2983
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0363 0.0695
Brugia malayi Dopamine receptor protein 1 0.0159 0.1378 0.1351
Loa Loa (eye worm) hypothetical protein 0.0031 0.019 0.0171
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0053 0.0021
Brugia malayi hypothetical protein 0.0017 0.0062 0.0031
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus multilocularis neuropeptide Y receptor 0.0159 0.1378 0.1834
Loa Loa (eye worm) hypothetical protein 0.0067 0.0528 0.051
Echinococcus granulosus cytochrome P450 2K1 0.0037 0.0247 0.0535
Echinococcus granulosus g-protein coupled receptor 0.0159 0.1378 0.2983
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0056 0.009
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0051 0.0068
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0363 0.3598
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0053 0.007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.019 0.0411
Echinococcus multilocularis g protein coupled receptor 0.0159 0.1378 0.1834
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0053 0.007
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.1378 0.2983
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0031 0.0042
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0917 0.1495
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.1378 0.1834
Brugia malayi N-terminal motif family protein 0.0177 0.1552 0.1525
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.1601 0.3465
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0053 0.007
Schistosoma mansoni histamine h1 receptor 0.0159 0.1378 0.2961
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.019 0.0159
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0053 0.0114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.1378 0.2961
Brugia malayi tailless protein 0.0014 0.004 0.0008
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0363 0.3598
Schistosoma mansoni biogenic amine receptor 0.0159 0.1378 0.2961
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0014 0.0031
Echinococcus granulosus 7TM GPCR rhodopsin 0.0159 0.1378 0.2983
Brugia malayi nuclear receptor NHR-88 0.0031 0.019 0.0159
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0159 0.1378 0.1351
Schistosoma mansoni amine GPCR 0.0159 0.1378 0.2961
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.1885 0.1869
Schistosoma mansoni hypothetical protein 0.0282 0.2521 0.5442
Schistosoma mansoni opsin-like receptor 0.0159 0.1378 0.2961
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0159 0.1378 0.2983
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0159 0.1378 0.1351
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0031 0.0068
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.019 0.0253
Brugia malayi Calcitonin receptor-like protein seb-1 0.0303 0.2717 0.2694
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0697 0.6367 1
Loa Loa (eye worm) G-protein coupled receptor 0.0159 0.1378 0.1361
Trypanosoma cruzi cytochrome P450, putative 0.0055 0.0416 0.4212
Schistosoma mansoni survival motor neuron protein 0.0047 0.0339 0.0705
Brugia malayi Cytochrome P450 family protein 0.0037 0.0247 0.0216
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0395 0.0526
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0199 0.0402
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 0.1378 0.2961
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0528 0.1116
Toxoplasma gondii cytochrome p450 superfamily protein 0.0037 0.0247 0.0447
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.059 0.0785
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.019 0.0382
Schistosoma mansoni opsin-like receptor 0.0159 0.1378 0.2961
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0917 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1202 0.1174
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.004 0.0008
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0159 0.1378 0.1361
Schistosoma mansoni adenoreceptor 0.0159 0.1378 0.2961
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0053 0.007
Loa Loa (eye worm) CYP4Cod1 0.0055 0.0416 0.0398
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0839 0.1791
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0055 0.0416 0.0378
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0917 0.1849
Brugia malayi CXXC zinc finger family protein 0.0059 0.0452 0.0422
Trypanosoma cruzi cytochrome P450, putative 0.0055 0.0416 0.4212
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.059 0.125
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0335 0.0726
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.019 0.0253
Schistosoma mansoni zinc finger protein 0.0014 0.004 0.0055
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0159 0.1378 0.1834
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0363 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0031 0.0037
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0024 0.0032
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.4726 1
Echinococcus multilocularis inositol monophosphatase 1 0.0072 0.0576 0.0766
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0951 0.1949
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 0.1378 0.2983
Onchocerca volvulus 0.0032 0.0199 0.0755
Schistosoma mansoni cpg binding protein 0.0062 0.0483 0.1018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.019 0.0159
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0159 0.1378 0.1834
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.1378 0.2961
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0031 0.0068
Entamoeba histolytica hypothetical protein 0.0074 0.059 1
Brugia malayi cytochrome P450 0.0037 0.0247 0.0216
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0521 0.5417
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.019 0.0253
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0031 0.0068
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.4726 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0159 0.1378 0.2983
Onchocerca volvulus 0.0109 0.0917 0.4143
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0917 0.1368
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0031 0.0042
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.019 0.0411
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0053 0.0033
Schistosoma mansoni myosin xvIII 0.0159 0.1378 0.2961
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0917 0.122
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Brugia malayi beta-lactamase family protein 0.0109 0.0917 0.0888
Brugia malayi Melibiase family protein 0.0067 0.0528 0.0498
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0335 0.0446
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.1378 0.1834
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0031 0.0068
Onchocerca volvulus 0.0159 0.1378 0.6322
Brugia malayi hypothetical protein 0.0159 0.1378 0.1351
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0917 0.1368
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0177 0.0383
Brugia malayi RE15519p 0.0159 0.1378 0.1351
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0101 0.0839 0.1117
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0024 0.0052
Mycobacterium tuberculosis Conserved protein 0.0109 0.0917 0.1368
Loa Loa (eye worm) glutaminase 0.0271 0.242 0.2405
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Brugia malayi hypothetical protein 0.0016 0.0056 0.0024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.019 0.0253
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0037 0.0247 0.0308
Brugia malayi hypothetical protein 0.0159 0.1378 0.1351
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0148 0.0205
Schistosoma mansoni tar DNA-binding protein 0.0326 0.2929 0.6328
Schistosoma mansoni thyroid hormone receptor 0.0031 0.019 0.0382
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0261 0.0348
Schistosoma mansoni thyroid hormone receptor 0.0031 0.019 0.0382
Schistosoma mansoni neuropeptide receptor 0.0159 0.1378 0.2961
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.019 0.0159
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0452 0.0433
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.1378 0.2983
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.019 0.0253
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0036
Schistosoma mansoni hypothetical protein 0.0159 0.1378 0.2961
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Loa Loa (eye worm) RNA binding protein 0.0326 0.2929 0.2915
Brugia malayi nuclear receptor NHR-88 0.0014 0.004 0.0008
Brugia malayi nuclear receptor NHR-67 0.0014 0.004 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0482 0.1015
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus granulosus neuropeptide receptor 0.0159 0.1378 0.2983
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0482 0.1015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0199 0.0402
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.019 0.0171
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0036
Echinococcus granulosus G protein coupled receptor 139 0.0159 0.1378 0.2983
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0031 0.0042
Echinococcus multilocularis G protein coupled receptor 139 0.0159 0.1378 0.1834
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0363 0.108
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus granulosus lamin 0.0027 0.0151 0.0327
Brugia malayi beta-lactamase family protein 0.0109 0.0917 0.0888
Echinococcus granulosus neuropeptide FF receptor 2 0.0159 0.1378 0.2983
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.019 0.0159
Brugia malayi Dopamine receptor protein 2 0.0159 0.1378 0.1351
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0159 0.1378 0.1351
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0056 0.0024
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.019 0.0382
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0159 0.1378 0.1834
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.0506 0.0718
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2032 0.4398
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1202 0.2579
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0482 0.0524
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0037 0.0247 0.2253
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0159 0.1378 0.1834
Brugia malayi hypothetical protein 0.0159 0.1378 0.1351
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.1378 0.1834
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.1601 0.213
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0482 0.1043
Echinococcus multilocularis musashi 0.0027 0.0151 0.0201
Schistosoma mansoni hypothetical protein 0.0096 0.0795 0.1695
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0036
Schistosoma mansoni hypothetical protein 0.0096 0.0795 0.1695
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0795 0.0777
Echinococcus granulosus neuropeptide receptor 0.0159 0.1378 0.2983
Loa Loa (eye worm) hypothetical protein 0.0053 0.0395 0.0376
Brugia malayi putative neuropeptide receptor 0.0159 0.1378 0.1351
Brugia malayi ORL1-like opioid receptor 0.0159 0.1378 0.1351
Brugia malayi hypothetical protein 0.0159 0.1378 0.1351
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0159 0.1378 0.1834
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0199 0.0345
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0416 0.0398
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1202 0.1185
Schistosoma mansoni hypothetical protein 0.0207 0.1828 0.3937
Loa Loa (eye worm) hypothetical protein 0.0026 0.0148 0.0129
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.1378 0.2983
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0036
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0151 0.0132
Loa Loa (eye worm) MBCTL1 0.0053 0.0395 0.0376
Brugia malayi larval opioid receptor 0.0159 0.1378 0.1351
Loa Loa (eye worm) hypothetical protein 0.0207 0.1828 0.1812
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0303 0.2717 0.2694
Schistosoma mansoni hypothetical protein 0.0096 0.0795 0.1695
Echinococcus granulosus peptide allatostatin:somatostatin 0.0159 0.1378 0.2983
Brugia malayi nuclear receptor RXR 0.0014 0.004 0.0008
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 0.1378 0.2983
Trichomonas vaginalis glutaminase, putative 0.0271 0.242 0.7721
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.019 0.0411
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.1378 0.2961
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0159 0.1378 0.2983
Brugia malayi putative neuropeptide receptor NPR1 0.0159 0.1378 0.1351
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0576 0.6057
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0159 0.1378 0.1834
Brugia malayi MH2 domain containing protein 0.0121 0.1031 0.1003
Echinococcus multilocularis dro:myosuppressin receptor 0.0159 0.1378 0.1834
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0528 0.1116
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Echinococcus multilocularis orexin receptor type 2 0.0159 0.1378 0.1834
Onchocerca volvulus 0.0059 0.0452 0.1947
Mycobacterium ulcerans hypothetical protein 0.0109 0.0917 0.1495
Loa Loa (eye worm) TYRA-2 protein 0.0159 0.1378 0.1361
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.0506 0.0577
Brugia malayi ecdysteroid receptor 0.0031 0.019 0.0159
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0528 0.1612
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0395 0.0855
Schistosoma mansoni hypothetical protein 0.0096 0.0795 0.1695
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0031 0.0042
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0335 0.0698
Leishmania major hypothetical protein, conserved 0.0109 0.0917 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.019 0.0411
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0053 0.0083
Brugia malayi hypothetical protein 0.0159 0.1378 0.1351
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.0985 0.0967
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0576 0.6057
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Loa Loa (eye worm) hypothetical protein 0.0159 0.1378 0.1361
Schistosoma mansoni amine GPCR 0.0159 0.1378 0.2961
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.019 0.0411
Onchocerca volvulus 0.0027 0.0151 0.0527
Schistosoma mansoni tar DNA-binding protein 0.0326 0.2929 0.6328
Echinococcus granulosus inositol monophosphatase 1 0.0072 0.0576 0.1247
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0395 0.0855
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0053 0.0032
Echinococcus multilocularis neuropeptides capa receptor 0.0159 0.1378 0.1834
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0031 0.0068
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0031 0.0068
Echinococcus multilocularis neuropeptide receptor 0.0159 0.1378 0.1834
Echinococcus multilocularis neuropeptide receptor A26 0.0159 0.1378 0.1834
Brugia malayi beta-lactamase 0.0109 0.0917 0.0888
Loa Loa (eye worm) hypothetical protein 0.0031 0.019 0.0171
Loa Loa (eye worm) hypothetical protein 0.0031 0.019 0.0171
Schistosoma mansoni hypothetical protein 0.0074 0.059 0.125
Brugia malayi Tachykinin-like peptides receptor 99D 0.0159 0.1378 0.1351
Echinococcus granulosus tachykinin peptides receptor 99D 0.0159 0.1378 0.2983
Loa Loa (eye worm) hypothetical protein 0.0109 0.0917 0.0899
Brugia malayi Pre-SET motif family protein 0.0032 0.0199 0.0169
Onchocerca volvulus 0.0159 0.1378 0.6322
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0159 0.1378 0.2961
Onchocerca volvulus 0.0159 0.1378 0.6322
Echinococcus granulosus orexin receptor type 2 0.0159 0.1378 0.2983
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0148 0.1107
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0051 0.0111
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0072 0.0576 0.7978
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0014 0.0037 0.0051
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0917 0.0888
Schistosoma mansoni inositol monophosphatase 0.0072 0.0576 0.122
Loa Loa (eye worm) hypothetical protein 0.0031 0.019 0.0171
Brugia malayi G protein-coupled receptor 0.0159 0.1378 0.1351
Echinococcus multilocularis g-protein coupled receptor 0.0159 0.1378 0.1834
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0037 0.0247 0.0308
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0521 0.0693
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.019 0.0382
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.1378 0.1834
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.002
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0056 0.009
Schistosoma mansoni tar DNA-binding protein 0.0326 0.2929 0.6328
Echinococcus granulosus GPCR family 2 0.0096 0.0795 0.1721
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.004 0.002
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.019 0.0171
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0031 0.0037
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0795 0.0766
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1202 0.2602
Echinococcus multilocularis GPCR, family 2 0.0096 0.0795 0.1058
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0083 0.0051
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.019 0.0253
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0917 0.1959
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0031 0.0068
Schistosoma mansoni inositol monophosphatase 0.0072 0.0576 0.122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.019 0.0171
Schistosoma mansoni opsin-like receptor 0.0159 0.1378 0.2961

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.3 uM Inhibition of Escherichia coli M15 recombinant IspC using 1-deoxy-D-xylulose 5-phosphate as substrate by photometric analysis ChEMBL. 25254502
IC50 (functional) > 50 uM Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA ChEMBL. 25254502
IC50 (binding) = 429 uM Inhibition of Mycobacterium tuberculosis IspC using 1-deoxy-D-xylulose 5-phosphate as substrate by photometric analysis ChEMBL. 25254502

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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