Detailed information for compound 949498

Basic information

Technical information
  • TDR Targets ID: 949498
  • Name: MOLI001407
  • MW: 181.197 | Formula: C9H11FN2O
  • H donors: 1 H acceptors: 1 LogP: 1.02 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [18F]c1ncccc1OC[C@@H]1CCN1
  • InChi: 1S/C9H11FN2O/c10-9-8(2-1-4-12-9)13-6-7-3-5-11-7/h1-2,4,7,11H,3,5-6H2/t7-/m0/s1/i10-1
  • InChiKey: GVOOYVOZPRROMP-GBSHIBCGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[18F]FA
  • 2-[18F]Fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine
  • 2-[18F]Fluoro-A-85380

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-2 subunit Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor subunit alpha-3 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 References
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 References
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 References
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 References
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-4 subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Get druggable targets OG5_128160 All targets in OG5_128160
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Get druggable targets OG5_128160 All targets in OG5_128160
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Get druggable targets OG5_128160 All targets in OG5_128160
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Onchocerca volvulus Putative nachr subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 Get druggable targets OG5_128160 All targets in OG5_128160
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Neuronal acetylcholine receptor; alpha3/beta2   500 aa 521 aa 40.1 %
Schistosoma mansoni nAChR subunit Neuronal acetylcholine receptor subunit alpha-3   499 aa 538 aa 24.9 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 481 aa 38.0 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor protein alpha-2 subunit   511 aa 516 aa 42.6 %
Echinococcus granulosus acetylcholine receptor subunit beta 1 Neuronal acetylcholine receptor protein alpha-2 subunit   511 aa 538 aa 33.3 %
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein Neuronal acetylcholine receptor subunit alpha-3   499 aa 507 aa 25.2 %
Onchocerca volvulus Neuronal acetylcholine receptor protein alpha-2 subunit   511 aa 497 aa 38.8 %
Onchocerca volvulus Putative zinc finger protein Neuronal acetylcholine receptor protein alpha-2 subunit   511 aa 542 aa 41.5 %
Echinococcus multilocularis nAChR subunit Neuronal acetylcholine receptor protein alpha-2 subunit   511 aa 481 aa 31.0 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Neuronal acetylcholine receptor; alpha3/beta2   500 aa 492 aa 39.8 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor subunit alpha-3   499 aa 495 aa 44.2 %
Onchocerca volvulus Neuronal acetylcholine receptor; alpha2/beta4   495 aa 502 aa 40.0 %
Schistosoma mansoni nAChR subunit Neuronal acetylcholine receptor subunit alpha-3   499 aa 546 aa 26.0 %
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Neuronal acetylcholine receptor subunit alpha-3   499 aa 477 aa 36.9 %
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 Neuronal acetylcholine receptor subunit alpha-3   499 aa 569 aa 25.5 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type des-2 homolog Neuronal acetylcholine receptor protein alpha-2 subunit   511 aa 527 aa 26.9 %
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Neuronal acetylcholine receptor; alpha3/beta2   500 aa 511 aa 40.9 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 507 aa 37.9 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Neuronal acetylcholine receptor protein alpha-2 subunit   511 aa 495 aa 25.1 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Neuronal acetylcholine receptor subunit alpha-3   499 aa 493 aa 41.6 %
Onchocerca volvulus Neuronal acetylcholine receptor subunit alpha-3   499 aa 485 aa 38.6 %
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 Neuronal acetylcholine receptor subunit alpha-3   499 aa 569 aa 25.8 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Neuronal acetylcholine receptor protein alpha-2 subunit   511 aa 491 aa 38.9 %
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Neuronal acetylcholine receptor protein alpha-2 subunit   511 aa 517 aa 26.1 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 487 aa 34.3 %
Onchocerca volvulus Neuronal acetylcholine receptor subunit alpha-3   499 aa 549 aa 24.0 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Neuronal acetylcholine receptor subunit alpha-3   499 aa 517 aa 36.0 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 508 aa 34.3 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor subunit alpha-3   499 aa 495 aa 44.2 %
Brugia malayi Cation transporter family protein Neuronal acetylcholine receptor subunit alpha-3   499 aa 489 aa 33.9 %
Onchocerca volvulus Neuronal acetylcholine receptor subunit alpha-3   499 aa 477 aa 36.9 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-2 subunit   511 aa 525 aa 41.9 %
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 491 aa 37.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0196 0.1146 0.1342
Schistosoma mansoni biogenic amine receptor 0.0026 0.0093 0.0136
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0176 0.0197
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0093 0.0136
Brugia malayi hypothetical protein 0.0058 0.0294 0.0484
Entamoeba histolytica hypothetical protein 0.0023 0.0075 0.11
Onchocerca volvulus 0.0026 0.0093 0.0132
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0013 0.0014 0.0111
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0173 0.1003 0.1658
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0061 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Onchocerca volvulus 0.0033 0.0137 0.0204
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0098
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0363 0.3105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0061 0.0098
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0093 0.0136
Schistosoma mansoni rab6-interacting 0.0019 0.0053 0.0078
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0093 0.0093
Giardia lamblia Inositol 5-phosphatase 4 0.0013 0.0014 0.0111
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0294 0.9077
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0072 0.1975
Schistosoma mansoni smad1 5 8 and 0.006 0.0304 0.0445
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0093 0.0093
Brugia malayi neuropeptide F receptor 0.0026 0.0093 0.0151
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.043 0.2583 0.4276
Onchocerca volvulus 0.0026 0.0093 0.0132
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0093 0.0151
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0072 0.0544
Echinococcus granulosus phd:f box containing protein 0.0016 0.0036 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.01 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0061 0.0098
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.008 0.0428 0.0706
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0061 0.0089
Echinococcus granulosus neuropeptide receptor 0.0026 0.0093 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0093 0.0136
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0093 0.0093
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0019 0.005 0.005
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0013 0.0014 0.0111
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0093 0.0093
Echinococcus granulosus g protein coupled receptor 0.0026 0.0093 0.0136
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0173 0.1003 0.1658
Leishmania major hypothetical protein, conserved 0.0013 0.0014 0.0111
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0036 0.0053
Trichomonas vaginalis ap endonuclease, putative 0.0063 0.0323 0.0366
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Brugia malayi hypothetical protein 0.0026 0.0093 0.0151
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0019 0.005 0.0043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0093 0.0136
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0014 0.0111
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0013 0.0014 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0061 0.0098
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0014 0.0111
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0093 0.0136
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0093 0.0093
Leishmania major importin beta-1 subunit, putative 0.0024 0.0086 0.2419
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Brugia malayi hypothetical protein 0.0038 0.0167 0.0274
Echinococcus granulosus MAM 0.0033 0.0137 0.02
Onchocerca volvulus 0.008 0.0428 0.0687
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.031 0.031
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0014 0.003
Schistosoma mansoni neuropeptide receptor 0.0026 0.0093 0.0136
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0072 0.1975
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0093 0.0093
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0014 0.0111
Echinococcus multilocularis nAChR subunit 0.0173 0.1003 0.1003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0063 0.0323 0.0532
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Schistosoma mansoni TGF-beta signal transducer Smad2 0.006 0.0304 0.0445
Entamoeba histolytica heat shock transcription factor, putative 0.0103 0.0573 1
Echinococcus multilocularis snurportin 1 0.0321 0.1916 0.1916
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0214 0.1797
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0061 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0088 0.0015
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0012 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0384 0.0562
Echinococcus granulosus glycine receptor subunit alpha 1 0.0173 0.1003 0.1466
Echinococcus granulosus g protein coupled receptor 0.0026 0.0093 0.0136
Schistosoma mansoni thyroid hormone receptor 0.002 0.0061 0.0089
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0014 0.002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0093 0.0093
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0173 0.1003 0.1658
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0075 0.208
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0093 0.0136
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0093 0.051 0.0842
Loa Loa (eye worm) acetyltransferase 0.0168 0.097 0.1604
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0214 0.6529
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0079
Echinococcus granulosus somatostatin receptor 0.0026 0.0093 0.0136
Loa Loa (eye worm) hypothetical protein 0.0081 0.0432 0.0713
Schistosoma mansoni hypothetical protein 0.0157 0.0903 0.1321
Schistosoma mansoni nuclear hormone receptor 0.002 0.0061 0.0089
Schistosoma mansoni opsin-like receptor 0.0026 0.0093 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Onchocerca volvulus 0.0173 0.1003 0.1641
Schistosoma mansoni hypothetical protein 0.0019 0.0053 0.0078
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.2381 0.2381
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0093 0.0093
Brugia malayi hypothetical protein 0.0033 0.0137 0.0224
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0157 0.0903 0.0903
Brugia malayi hypothetical protein 0.0019 0.005 0.008
Schistosoma mansoni hypothetical protein 0.0157 0.0903 0.1321
Leishmania major endonuclease/exonuclease protein-like protein 0.0013 0.0014 0.0111
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Mycobacterium ulcerans L-lysine aminotransferase 0.0196 0.1146 0.1346
Onchocerca volvulus 0.0093 0.051 0.0824
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0096 0.0141
Schistosoma mansoni cpg binding protein 0.0035 0.0152 0.0223
Echinococcus multilocularis synaptojanin 1 0.0013 0.0014 0.0014
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0033 0.0048
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0014 0.002
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0013 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0036 0.023
Onchocerca volvulus 0.0026 0.0093 0.0132
Brugia malayi Melatonin receptor type 1A 0.0026 0.0093 0.0151
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0093 0.0151
Schistosoma mansoni hypothetical protein 0.0321 0.1916 0.2802
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0196 0.1146 0.1677
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.043 0.2583 0.2583
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0061 0.0098
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0088 0.1328
Brugia malayi jmjC domain containing protein 0.0061 0.0314 0.0517
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0093 0.0093
Brugia malayi hypothetical protein 0.008 0.0428 0.0706
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0088 0.0088
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0093 0.0136
Onchocerca volvulus 0.099 0.604 1
Echinococcus granulosus glycine receptor subunit beta 0.0173 0.1003 0.1466
Echinococcus granulosus dna polymerase kappa 0.0039 0.0176 0.0258
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0093 0.0093
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0053 0.0085
Brugia malayi MH2 domain containing protein 0.0027 0.01 0.0163
Schistosoma mansoni acetylcholine receptor subunit beta 0.008 0.0428 0.0626
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0061 0.0098
Schistosoma mansoni hypothetical protein 0.112 0.6838 1
Brugia malayi Doublecortin family protein 0.0019 0.0053 0.0085
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.031 0.2642
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0061 0.0089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0093 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0093 0.0093
Echinococcus multilocularis Smad4 0.006 0.0304 0.0304
Brugia malayi G protein-coupled receptor 0.0026 0.0093 0.0151
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0093 0.0136
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0093 0.0136
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0196 0.1146 0.1279
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0063 0.0323 0.037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0093 0.0093
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0014 0.003
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.008 0.0428 0.0428
Schistosoma mansoni GTP-binding protein alpha subunit 0.0019 0.005 0.0074
Schistosoma mansoni smad 0.006 0.0304 0.0445
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0121 0.3541
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.1382 0.8453 1
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0196 0.1146 0.1346
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0026 0.0093 0.0136
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.031 0.0454
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0019 0.005 0.0074
Onchocerca volvulus 0.0061 0.031 0.0492
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0093 0.0093
Brugia malayi neuropeptide F receptor 0.0026 0.0093 0.0151
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0019 0.005 0.008
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.043 0.2583 0.3778
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0088 0.0088
Echinococcus granulosus geminin 0.112 0.6838 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0102 0.2922
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0019 0.005 0.008
Brugia malayi hypothetical protein 0.0026 0.0093 0.0151
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0072 0.0105
Schistosoma mansoni amine GPCR 0.0026 0.0093 0.0136
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0033 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0093 0.0136
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0496 0.2993 0.4955
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0093 0.0136
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0102 0.2922
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0173 0.1003 0.1658
Schistosoma mansoni hypothetical protein 0.0339 0.2026 0.2963
Brugia malayi hypothetical protein 0.0247 0.1457 0.241
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Echinococcus granulosus Smad4 0.006 0.0304 0.0445
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0086 0.2419
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0196 0.1146 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0093 0.0093
Brugia malayi hypothetical protein 0.0026 0.0093 0.0151
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Loa Loa (eye worm) pax transcription factor protein 2 0.0474 0.2858 0.4731
Brugia malayi Pre-SET motif family protein 0.042 0.2523 0.4176
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0093 0.0151
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0196 0.1146 0.1346
Echinococcus multilocularis serotonin receptor 0.0026 0.0093 0.0093
Schistosoma mansoni Smad4 0.0027 0.01 0.0146
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0061 0.0089
Schistosoma mansoni smad1 5 8 and 0.006 0.0304 0.0445
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0157 0.0903 0.1493
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0013 0.0014 0.0014
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0641 0.0937
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0019 0.005 0.0074
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0093 0.0136
Schistosoma mansoni cpg binding protein 0.0035 0.0152 0.0223
Loa Loa (eye worm) latrophilin receptor protein 2 0.0157 0.0903 0.1493
Onchocerca volvulus 0.0019 0.005 0.0061
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Schistosoma mansoni lozenge 0.0124 0.0701 0.1025
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0176 0.0193
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0432 0.0633
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.031 0.0454
Trypanosoma brucei unspecified product 0.0027 0.0102 0.2922
Echinococcus multilocularis Protein lozenge 0.0124 0.0701 0.0701
Leishmania major hypothetical protein, conserved 0.0016 0.0036 0.0836
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0019 0.005 0.0043
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0049 0.0046
Plasmodium vivax SET domain protein, putative 0.0061 0.031 0.2642
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0093 0.0136
Loa Loa (eye worm) TK/ALK protein kinase 0.0274 0.1624 0.2687
Echinococcus granulosus importin subunit beta 1 0.003 0.0121 0.0177
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0014 0.002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0093 0.0093
Echinococcus granulosus snurportin 1 0.0321 0.1916 0.2802
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0196 0.1146 0.1279
Echinococcus multilocularis geminin 0.112 0.6838 0.6838
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0093 0.0136
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0093 0.0136
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0093 0.0136
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0196 0.1146 0.1342
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.043 0.2583 0.4276
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0079
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0014 0.0111
Schistosoma mansoni biogenic amine receptor 0.0026 0.0093 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0093 0.0136
Brugia malayi isocitrate dehydrogenase 0.0016 0.0033 0.0051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0173 0.1003 0.1658
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0036 0.023
Brugia malayi CCR4 0.0013 0.0014 0.002
Brugia malayi mothers against decapentaplegic homolog 3 0.0027 0.01 0.0163
Leishmania major hypothetical protein, conserved 0.0013 0.0014 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0093 0.0136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0176 0.0193
Leishmania major hypothetical protein, conserved 0.0058 0.0294 0.9077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0093 0.0136
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0325 0.0536
Loa Loa (eye worm) hypothetical protein 0.099 0.604 1
Schistosoma mansoni polycystin 1-related 0.0019 0.0053 0.0078
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.0294 0.2498
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0075 0.208
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0093 0.051 0.0842
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0036 0.0053
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0063 0.0323 0.0366
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0079
Schistosoma mansoni neutral sphingomyelinase 0.0013 0.0014 0.002
Onchocerca volvulus 0.0026 0.0093 0.0132
Trypanosoma brucei unspecified product 0.0027 0.0102 0.2922
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0093 0.0093
Brugia malayi Importin beta-1 subunit 0.003 0.0121 0.0197
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Entamoeba histolytica heat shock transcription factor, putative 0.0103 0.0573 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0093 0.0093
Loa Loa (eye worm) transcription factor SMAD2 0.0877 0.5344 0.8848
Entamoeba histolytica Ran family GTPase 0.0022 0.0072 0.1042
Echinococcus multilocularis dna polymerase eta 0.0039 0.0176 0.0176
Echinococcus multilocularis traf and tnf receptor associated protein 0.0013 0.0014 0.0014
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0641 0.0641
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0061 0.0089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0434 0.2609 0.3816
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0049 0.0345
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0432 0.0432
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0088 0.0092
Schistosoma mansoni neurotransmitter gated ion channel 0.008 0.0428 0.0626
Entamoeba histolytica heat shock transcription factor, putative 0.0103 0.0573 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0027 0.01 0.0146
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.1457 0.1457
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0002 0.0002
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0036 0.0053
Brugia malayi steroid hormone receptor 0.002 0.0061 0.0098
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0061 0.0089
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0093 0.0151
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0093 0.0093
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0019 0.005 0.008
Brugia malayi Cation transporter family protein 0.0173 0.1003 0.1658
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0061 0.0098
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0093 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0093 0.0136
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0196 0.1146 0.1342
Brugia malayi RE15519p 0.0026 0.0093 0.0151
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0173 0.1003 0.1466
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.043 0.2583 0.2583
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0019 0.005 0.0074
Plasmodium vivax exodeoxyribonuclease III, putative 0.0013 0.0014 0.003
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0176 0.0289
Loa Loa (eye worm) ACC-1 protein 0.0173 0.1003 0.1658
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0049 0.0042
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0053 0.0053
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.024 0.0268
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0294 0.9077
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0093 0.0132
Treponema pallidum exodeoxyribonuclease (exoA) 0.0063 0.0323 1
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0014 0.003
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0173 0.1003 0.1003
Onchocerca volvulus 0.0026 0.0093 0.0132
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0072 0.0544
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0014 0.002
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0173 0.1003 0.1003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0057
Brugia malayi ORL1-like opioid receptor 0.0026 0.0093 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0061 0.0098
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0093 0.0136
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0019 0.005 0.008
Brugia malayi CXXC zinc finger family protein 0.0033 0.0141 0.023
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0173 0.1003 0.1658
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.043 0.2583 0.2583
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0061 0.0061
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0014 0.002
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.008 0.0428 0.0626
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0036 0.0053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0014 0.0111
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0176 0.0176
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0014 0.0111
Brugia malayi Latrophilin receptor protein 2 0.0157 0.0903 0.1493
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0088 0.2487
Brugia malayi hypothetical protein 0.099 0.604 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0088 0.0092
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Schistosoma mansoni nAChR subunit 0.0173 0.1003 0.1466
Leishmania major hypothetical protein, conserved 0.0013 0.0014 0.0111
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0049 0.0345
Echinococcus granulosus ornithine aminotransferase 0.0196 0.1146 0.1677
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0019 0.005 0.008
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0093 0.0136
Schistosoma mansoni hypothetical protein 0.0026 0.0096 0.0141
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0063 0.0323 0.0472
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0098
Loa Loa (eye worm) hypothetical protein 0.0033 0.0137 0.0224
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0098
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0013 0.0014 0.0111
Leishmania major pantothenate kinase subunit, putative 0.0014 0.002 0.031
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0196 0.1146 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0063 0.0323 1
Loa Loa (eye worm) nuclear factor I 0.0033 0.0139 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0434 0.2609 0.2609
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0093 0.0093
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0014 0.002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0061 0.0078
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0014 0.002
Schistosoma mansoni hypothetical protein 0.005 0.0246 0.0359
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0014 0.002
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0093 0.0136
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0093 0.0151
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0093 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.002
Schistosoma mansoni neurotransmitter gated ion channel 0.0093 0.051 0.0746
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.1457 0.213
Trypanosoma brucei unspecified product 0.0039 0.0176 0.5312
Onchocerca volvulus 0.0026 0.0093 0.0132
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0013 0.0014 0.0111
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Echinococcus granulosus nAChR subunit 0.0173 0.1003 0.1466
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Schistosoma mansoni nAChR subunit 0.008 0.0428 0.0626
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0061 0.0098
Loa Loa (eye worm) hypothetical protein 0.0033 0.0137 0.0224
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0019 0.005 0.008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Schistosoma mansoni GTP-binding protein alpha subunit 0.0019 0.005 0.0074
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0061 0.0089
Loa Loa (eye worm) acetylcholine receptor protein 0.008 0.0428 0.0706
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0019 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0085
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0061 0.0089
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.0163
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0036 0.0036
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0013 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0019 0.005 0.0043
Brugia malayi jmjC domain containing protein 0.0016 0.0036 0.0057
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.031 0.031
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0093 0.0136
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0093 0.0093
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0061 0.0089
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.008 0.0428 0.0706
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0325 0.0476
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0088 0.1328
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0019 0.005 0.0043
Brugia malayi GnHR receptor homolog 0.0026 0.0093 0.0151
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0088 0.2487
Brugia malayi exodeoxyribonuclease III family protein 0.0063 0.0323 0.0532
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0196 0.1146 0.1346
Echinococcus multilocularis glycine receptor subunit beta 0.0173 0.1003 0.1003
Schistosoma mansoni nAChR subunit 0.0173 0.1003 0.1466
Onchocerca volvulus 0.0026 0.0093 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0061 0.0098
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0019 0.005 0.008
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0093 0.0136
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.031 0.0454
Entamoeba histolytica hypothetical protein 0.0093 0.051 0.8876
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0061 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.031 0.0454
Echinococcus multilocularis ornithine aminotransferase 0.0196 0.1146 0.1146
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0093 0.0136
Plasmodium falciparum ornithine aminotransferase 0.0196 0.1146 1
Echinococcus granulosus fmrfamide receptor 0.0026 0.0093 0.0136
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0075 0.0572
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.1382 0.8453 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0167 0.0244
Brugia malayi jmjC domain containing protein 0.0016 0.0036 0.0057
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0093 0.051 0.0746
Brugia malayi hypothetical protein 0.008 0.0428 0.0706
Brugia malayi HSF-type DNA-binding domain containing protein 0.0103 0.0573 0.0947
Entamoeba histolytica hypothetical protein 0.0038 0.0167 0.2738
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0434 0.2609 0.3816
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.1916 0.317
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0048 0.0048
Brugia malayi RNA, U transporter 1 0.0086 0.0463 0.0764
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.008 0.0428 0.0706
Echinococcus multilocularis RUN 0.0019 0.0053 0.0053
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0093 0.0136
Loa Loa (eye worm) MH1 domain-containing protein 0.006 0.0304 0.0501
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0013 0.0014 0.0014
Echinococcus granulosus cpg binding protein 0.0035 0.0152 0.0223
Loa Loa (eye worm) hypothetical protein 0.0033 0.0139 0.0228
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.008
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0033 0.0033
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0014 0.002
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0086 0.0086
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0093 0.0093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0093 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0088 0.0143
Schistosoma mansoni hypothetical protein 0.0033 0.0137 0.02
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0176 0.5312
Onchocerca volvulus 0.0019 0.005 0.0061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0043 0.0035
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0168 0.097 0.1419
Loa Loa (eye worm) hypothetical protein 0.0093 0.051 0.0842
Onchocerca volvulus 0.008 0.0428 0.0687
Echinococcus granulosus traf and tnf receptor associated protein 0.0013 0.0014 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0173 0.1003 0.1658
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0093 0.0151
Echinococcus granulosus GPCR family 2 0.0157 0.0903 0.1321
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0434 0.2609 0.4319
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0075 0.0073
Schistosoma mansoni nAChR subunit 0.0173 0.1003 0.1466
Brugia malayi hypothetical protein 0.0038 0.0167 0.0274
Echinococcus multilocularis importin subunit beta 1 0.003 0.0121 0.0121
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0196 0.1146 0.1279
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0019 0.005 0.0043
Loa Loa (eye worm) hypothetical protein 0.0247 0.1457 0.241
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0072 0.0116
Brugia malayi MH1 domain containing protein 0.006 0.0304 0.0501
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0033 0.0198
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0013 0.0014 0.0111
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0033 0.0198
Trypanosoma cruzi mitochondrial protein 99, putative 0.0013 0.0014 0.0111
Echinococcus granulosus glycine receptor subunit beta 0.0173 0.1003 0.1466
Echinococcus multilocularis nAChR subunit 0.0093 0.051 0.051
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0093 0.0136
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.002
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0093 0.0093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0093 0.0093
Brugia malayi jmjC domain containing protein 0.0016 0.0036 0.0057
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0098
Onchocerca volvulus 0.0173 0.1003 0.1641
Echinococcus multilocularis mothers against decapentaplegic 5 0.006 0.0304 0.0304
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.0294 0.9077
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0196 0.1146 0.1342
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0173 0.1003 0.1003
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0014 0.0111
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0053 0.0379
Brugia malayi MH2 domain containing protein 0.0877 0.5344 0.8848
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0027 0.01 0.0144
Echinococcus multilocularis ornithine aminotransferase 0.0196 0.1146 0.1146
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0173 0.1003 0.1466
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0093 0.0136
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0432 0.0633
Schistosoma mansoni amine GPCR 0.0026 0.0093 0.0136
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0072 0.1975
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0088 0.2487
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0173 0.1003 0.1466
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0019 0.005 0.005
Schistosoma mansoni smad1 5 8 and 0.006 0.0304 0.0445
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0093 0.0151
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0061 0.0089
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0093 0.0136
Echinococcus multilocularis neutral sphingomyelinase 0.0013 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0098
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0013 0.0014 0.0111
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0168 0.097 0.097
Leishmania major DNA polymerase eta, putative 0.0039 0.0176 0.5312
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0093 0.0136
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0061 0.0089
Brugia malayi hypothetical protein 0.0026 0.0093 0.0151
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0173 0.1003 0.1003
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0019 0.005 0.0074
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0173 0.1003 0.1658
Loa Loa (eye worm) hypothetical protein 0.0033 0.0137 0.0224
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0173 0.1003 0.1658
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.001 0.0015
Schistosoma mansoni nAChR subunit 0.0173 0.1003 0.1466
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0072 0.1975
Echinococcus granulosus RUN 0.0019 0.0053 0.0078
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0063 0.0323 0.2752
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Onchocerca volvulus 0.0019 0.005 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0103 0.0573 0.0929
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0053 0.0379
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0013 0.0014 0.002
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0019 0.005 0.008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0496 0.2993 0.4955
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0093 0.0151
Schistosoma mansoni Smad4 0.006 0.0304 0.0445
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0176 0.5312
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0075 0.0572
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0013 0.0014 0.0111
Entamoeba histolytica hypothetical protein 0.0038 0.0167 0.2738
Onchocerca volvulus 0.005 0.0246 0.0385
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0085
Echinococcus granulosus synaptojanin 1 0.0013 0.0014 0.002
Onchocerca volvulus 0.0033 0.0137 0.0204
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0036 0.0036
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0093 0.0136
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0036 0.0053
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0019 0.005 0.0074
Echinococcus granulosus mothers against decapentaplegic 5 0.006 0.0304 0.0445
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0121 0.3541
Schistosoma mansoni acetylcholine receptor-related 0.008 0.0428 0.0626
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0093 0.0136
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.024 0.202
Echinococcus granulosus hypothetical protein 0.0026 0.0093 0.0136
Loa Loa (eye worm) hypothetical protein 0.0093 0.051 0.0842
Onchocerca volvulus 0.0173 0.1003 0.1641
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.043 0.2583 0.3778
Entamoeba histolytica hypothetical protein 0.0038 0.0167 0.2738
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0143
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0061 0.0061
Brugia malayi jmjC domain containing protein 0.0016 0.0036 0.0057
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0157 0.0903 0.1321
Schistosoma mansoni ap endonuclease 0.0063 0.0323 0.0472
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0173 0.1003 0.1003
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0013 0.0014 0.0111
Leishmania major GTP-binding protein, putative 0.0022 0.0072 0.1975
Brugia malayi G-protein coupled receptor 0.0026 0.0093 0.0151
Onchocerca volvulus 0.0173 0.1003 0.1641
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0019 0.005 0.008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0061 0.0089
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0072 0.0116
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0019 0.005 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0043 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0088 0.0143
Echinococcus granulosus mothers against decapentaplegic 2 0.0027 0.01 0.0146
Schistosoma mansoni cpg binding protein 0.0033 0.0141 0.0206
Echinococcus multilocularis glycine receptor subunit beta 0.0173 0.1003 0.1003
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0013 0.0014 0.0111
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0093 0.051 0.0842
Brugia malayi nuclear hormone receptor 0.002 0.0061 0.0098
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0036 0.0053
Onchocerca volvulus 0.0025 0.0088 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0019 0.005 0.008
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0075 0.0077
Echinococcus granulosus nAChR subunit 0.0093 0.051 0.0746
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0093 0.0151
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0063 0.0323 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0053 0.0078
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0033 0.0198
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0093 0.0136
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0093 0.0136
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0019 0.005 0.0043
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Echinococcus granulosus smad 0.006 0.0304 0.0445
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0033 0.0023
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0173 0.1003 0.1466
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0061 0.0098
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0033 0.072
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0093 0.0151
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0141 0.023
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0176 0.0258
Trypanosoma brucei RNA editing exonuclease 2 0.0013 0.0014 0.0111
Onchocerca volvulus 0.0019 0.0053 0.0066
Trichomonas vaginalis ran, putative 0.0022 0.0072 0.0069
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.1382 0.8453 1
Echinococcus granulosus sex peptide receptor 0.0026 0.0093 0.0136
Plasmodium vivax importin-beta 2, putative 0.003 0.0121 0.0975
Brugia malayi acetyltransferase, GNAT family protein 0.0168 0.097 0.1604
Schistosoma mansoni hypothetical protein 0.0397 0.2381 0.3482
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0093 0.051 0.0842
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0176 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0061 0.0098
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.002
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0093 0.0136
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.008 0.0428 0.0706
Brugia malayi hypothetical protein 0.0019 0.0053 0.0085
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0173 0.1003 0.1466
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0036 0.0053
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0093 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Brugia malayi sulfakinin receptor protein 0.0026 0.0093 0.0151
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0002 0.0002
Plasmodium falciparum DNase I-like protein, putative 0.0013 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.0058 0.0294 0.0484
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0093 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0096 0.0096
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0013 0.0014 0.002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0173 0.1003 0.1466
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.024 0.0351
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Brugia malayi hypothetical protein 0.008 0.0428 0.0706
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Schistosoma mansoni ran 0.0022 0.0072 0.0105
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0013 0.0014 0.003
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0093 0.0136
Onchocerca volvulus 0.0474 0.2858 0.472
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.0294 0.2498
Schistosoma mansoni nAChR subunit 0.0173 0.1003 0.1466
Echinococcus multilocularis TGF beta signal transducer SmadC 0.006 0.0304 0.0304
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0176 0.5312
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.031 0.0454
Onchocerca volvulus 0.0019 0.0053 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0061 0.0098
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0014 0.0111
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0061 0.0061
Echinococcus granulosus histone acetyltransferase KAT2B 0.0163 0.0941 0.1376
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0033 0.0051
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0019 0.005 0.0074
Brugia malayi hypothetical protein 0.0026 0.0093 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0093 0.0093
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0019 0.005 0.008
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0036 0.023
Plasmodium vivax ornithine aminotransferase, putative 0.0196 0.1146 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0061 0.0089
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0176 0.0258
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0093 0.0093
Schistosoma mansoni biogenic amine receptor 0.0026 0.0093 0.0136
Onchocerca volvulus 0.0026 0.0093 0.0132
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0173 0.1003 0.1658
Brugia malayi Dopamine receptor protein 2 0.0026 0.0093 0.0151
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0434 0.2609 0.4319
Brugia malayi Protein kinase domain containing protein 0.0274 0.1624 0.2688
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0033 0.072
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0053 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0061 0.0098
Schistosoma mansoni hypothetical protein 0.0026 0.0093 0.0136
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0176 0.0176
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.008 0.0428 0.0706
Toxoplasma gondii exonuclease III APE 0.0063 0.0323 0.2752
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0093 0.0136
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0093 0.0151
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0075 0.0572
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0093 0.0093
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0173 0.1003 0.1658
Schistosoma mansoni hypothetical protein 0.0038 0.0167 0.0244
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0314 0.0459
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0061 0.0061
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0093 0.0093
Echinococcus granulosus glycine receptor subunit alpha 1 0.0173 0.1003 0.1466
Schistosoma mansoni ap endonuclease 0.0063 0.0323 0.0472
Echinococcus granulosus dnaJ subfamily B 0.0397 0.2381 0.3482
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0033 0.0033
Loa Loa (eye worm) Smad1 0.006 0.0304 0.0501
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0432 0.0713
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0314 0.0459
Loa Loa (eye worm) MH2 domain-containing protein 0.0877 0.5344 0.8848
Plasmodium vivax JmjC domain containing protein 0.0016 0.0036 0.023
Entamoeba histolytica hypothetical protein 0.0024 0.0086 0.129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0434 0.2609 0.2609
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0033 0.0048
Schistosoma mansoni hypothetical protein 0.0157 0.0903 0.1321
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0014 0.002 0.031
Schistosoma mansoni Smad4 0.0027 0.01 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0043 0.0035
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0173 0.1003 0.1658
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Echinococcus multilocularis cpg binding protein 0.0035 0.0152 0.0152
Loa Loa (eye worm) ACC-1 protein 0.0173 0.1003 0.1658
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0167 0.0244
Schistosoma mansoni amine GPCR 0.0026 0.0093 0.0136
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0246 0.0404
Echinococcus granulosus TGF beta signal transducer SmadC 0.006 0.0304 0.0445
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Brugia malayi larval opioid receptor 0.0026 0.0093 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0093 0.0136
Onchocerca volvulus 0.008 0.0428 0.0687
Echinococcus granulosus neuropeptide receptor 0.0026 0.0093 0.0136
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0173 0.1003 0.1003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0093 0.0136
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0014 0.003
Brugia malayi nuclear receptor NHR-88 0.002 0.0061 0.0098
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0053 0.0078
Schistosoma mansoni neuropeptide receptor 0.0026 0.0093 0.0136
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0093 0.0093
Echinococcus granulosus g protein coupled receptor 0.0026 0.0093 0.0136
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0434 0.2609 0.3816
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.008
Loa Loa (eye worm) hypothetical protein 0.099 0.604 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0013 0.0013
Trichomonas vaginalis set domain proteins, putative 0.0478 0.288 0.3396
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0121 0.0975
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0093 0.0151
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0093 0.0151
Loa Loa (eye worm) MH2 domain-containing protein 0.006 0.0304 0.0501
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0019 0.005 0.0074
Brugia malayi Serotonin receptor 0.0026 0.0093 0.0151
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0014 0.003
Schistosoma mansoni importin beta-1 0.003 0.0121 0.0177
Plasmodium falciparum importin beta, putative 0.003 0.0121 0.0975
Onchocerca volvulus 0.0026 0.0093 0.0132
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0072 0.0544
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Onchocerca volvulus 0.0026 0.0093 0.0132
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0019 0.005 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0093 0.0151
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0075 0.0572
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0173 0.1003 0.1003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0079
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0014 0.003
Brugia malayi hypothetical protein 0.0026 0.0093 0.0151
Brugia malayi MH2 domain containing protein 0.006 0.0304 0.0501
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.008
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0019 0.005 0.0074
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0292 0.0427
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0036 0.0057
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0434 0.2609 0.3816
Echinococcus granulosus orexin receptor type 2 0.0026 0.0093 0.0136
Brugia malayi hypothetical protein 0.008 0.0428 0.0706
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0036 0.0836
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0214 0.3586
Brugia malayi AKH receptor 0.0026 0.0093 0.0151
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0093 0.0093
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0086 0.0086
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0019 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0061 0.0098
Schistosoma mansoni nAChR subunit 0.0173 0.1003 0.1466
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0093 0.0136
Onchocerca volvulus 0.0026 0.0093 0.0132
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0061 0.0078
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0093 0.0151
Schistosoma mansoni hypothetical protein 0.112 0.6838 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0093 0.0132
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0093 0.0136
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0013 0.0014 0.002
Loa Loa (eye worm) GABA receptor subunit 0.0093 0.051 0.0842
Schistosoma mansoni thyroid hormone receptor 0.002 0.0061 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0088 0.0092
Brugia malayi hypothetical protein 0.0026 0.0093 0.0151
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0019 0.005 0.005
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.008 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0196 0.1146 0.1346
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0093 0.0093
Brugia malayi G-protein coupled receptor 0.0026 0.0093 0.0151
Schistosoma mansoni rab6-interacting 0.0019 0.0053 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0061 0.0098
Onchocerca volvulus 0.0173 0.1003 0.1641
Brugia malayi Smad1 0.006 0.0304 0.0501
Loa Loa (eye worm) hypothetical protein 0.0093 0.051 0.0842
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0093 0.0136
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0036 0.0057
Onchocerca volvulus 0.0026 0.0093 0.0132
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0075 0.0077
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.008 0.0428 0.0706
Loa Loa (eye worm) hypothetical protein 0.0496 0.2993 0.4955
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Onchocerca volvulus 0.0173 0.1003 0.1641
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0098
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0173 0.1003 0.1466
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0013 0.0014 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0088 0.0092
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0093 0.0136
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0093 0.0136
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0013 0.0014 0.0014
Schistosoma mansoni neuropeptide receptor 0.0026 0.0093 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Loa Loa (eye worm) hypothetical protein 0.0061 0.031 0.0511
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0075 0.0236
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0061 0.0089
Loa Loa (eye worm) hypothetical protein 0.0176 0.1023 0.1691
Brugia malayi hypothetical protein 0.0026 0.0093 0.0151
Schistosoma mansoni hypothetical protein 0.0026 0.0093 0.0136
Loa Loa (eye worm) runx1 0.0124 0.0701 0.1158
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0093 0.0136
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0061 0.0089
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0176 0.5312
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0093 0.0093
Echinococcus multilocularis MAM 0.0033 0.0137 0.0137
Echinococcus granulosus serotonin receptor 0.0026 0.0093 0.0136
Brugia malayi hypothetical protein 0.0176 0.1023 0.1691
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0093 0.0151
Schistosoma mansoni coup transcription factor 0.002 0.0061 0.0089
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0143
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0196 0.1146 0.1896
Onchocerca volvulus 0.0478 0.288 0.4756
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0314 0.0314
Loa Loa (eye worm) LGC-31 protein 0.0173 0.1003 0.1658
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0013 0.0014 0.003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0033 0.0033
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0036 0.0057
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0093 0.0151
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0173 0.1003 0.1658
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0002 0.0002
Onchocerca volvulus 0.0033 0.0141 0.0211
Loa Loa (eye worm) hypothetical protein 0.0093 0.051 0.0842
Echinococcus multilocularis serotonin receptor 0.0026 0.0093 0.0093
Mycobacterium ulcerans hypothetical protein 0.1382 0.8453 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.024 0.202
Loa Loa (eye worm) hypothetical protein 0.0339 0.2026 0.3352
Loa Loa (eye worm) hypothetical protein 0.0093 0.051 0.0842
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.1382 0.8453 1
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0093 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0088 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Schistosoma mansoni adenoreceptor 0.0026 0.0093 0.0136
Schistosoma mansoni neuropeptide receptor 0.0026 0.0093 0.0136
Echinococcus granulosus expressed protein 0.0019 0.005 0.0074
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0093 0.0136
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0088 0.0092
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0036 0.0036
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0014 0.003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0157 0.0903 0.0903
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Onchocerca volvulus 0.0026 0.0093 0.0132
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0033 0.0033
Onchocerca volvulus 0.0026 0.0093 0.0132
Schistosoma mansoni lipoxygenase 0.008 0.0428 0.0626
Schistosoma mansoni smad 0.0027 0.01 0.0146
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.008 0.0428 0.0626
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Schistosoma mansoni synaptojanin 0.0013 0.0014 0.002
Brugia malayi ecdysteroid receptor 0.002 0.0061 0.0098
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0061 0.0098
Onchocerca volvulus 0.0081 0.0432 0.0695
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0063 0.0323 0.5526
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0033 0.072
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0019 0.005 0.0074
Leishmania major DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Brugia malayi Serotonin receptor 0.0026 0.0093 0.0151
Schistosoma mansoni hypothetical protein 0.0013 0.0014 0.002
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0014 0.002
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0173 0.1003 0.1658
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0173 0.1003 0.1466
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0086 0.0086
Brugia malayi MH1 domain containing protein 0.0033 0.0139 0.0228
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0019 0.005 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0093 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0061 0.0098
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0013 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.0063 0.0323 0.0366
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0088 0.0015
Mycobacterium ulcerans acetylornithine aminotransferase 0.0196 0.1146 0.1346
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0019 0.005 0.005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.008 0.0428 0.0706
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0173 0.1003 0.1658
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0019 0.005 0.0043
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0176 0.0193
Onchocerca volvulus Putative nachr subunit 0.043 0.2583 0.4264
Schistosoma mansoni amine GPCR 0.0026 0.0093 0.0136
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0173 0.1003 0.1466
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0063 0.0323 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0014 0.002
Brugia malayi G-protein alpha subunit 0.0019 0.005 0.008
Brugia malayi Dopamine receptor 0.0026 0.0093 0.0151
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0176 0.0197
Loa Loa (eye worm) G protein alpha subunit 3 0.0019 0.005 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0093 0.0136
Brugia malayi hypothetical protein 0.0026 0.0093 0.0151
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0496 0.2993 0.4955
Loa Loa (eye worm) hypothetical protein 0.024 0.1415 0.2341
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0157 0.0903 0.1321
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0176 0.5312
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0019 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0173 0.1003 0.1658
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0088 0.0092
Loa Loa (eye worm) hypothetical protein 0.043 0.2583 0.4276
Schistosoma mansoni hypothetical protein 0.0033 0.0137 0.02
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0061 0.0098
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0093 0.0136
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0173 0.1003 0.1466
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0176 0.0193
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0063 0.0323 0.2312
Brugia malayi excitatory GABA receptor EXP-1A 0.0173 0.1003 0.1658
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0061 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Schistosoma mansoni synaptojanin 0.0013 0.0014 0.002
Brugia malayi hypothetical protein 0.008 0.0428 0.0706
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.0197
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0167 0.0167
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0176 0.5312
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0173 0.1003 0.1466
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0013 0.0014 0.003
Onchocerca volvulus 0.0026 0.0093 0.0132
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0043 0.0035
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0093 0.0136
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.008 0.0428 0.0706
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0013 0.0014 0.003
Schistosoma mansoni histamine h1 receptor 0.0026 0.0093 0.0136
Echinococcus multilocularis GPCR, family 2 0.0157 0.0903 0.0903
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0093 0.0093
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0176 0.0289
Brugia malayi N-terminal motif family protein 0.018 0.1047 0.1731
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0098
Brugia malayi Cation transporter family protein 0.0173 0.1003 0.1658
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0061 0.0061
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.1047 0.1715
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0013 0.0014 0.003
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0093 0.0151
Echinococcus multilocularis mothers against decapentaplegic 2 0.0027 0.01 0.01
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0061 0.0098
Onchocerca volvulus 0.0026 0.0093 0.0132
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0176 0.0289
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0093 0.0093
Schistosoma mansoni amine GPCR 0.0026 0.0093 0.0136
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0173 0.1003 0.1658
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0061 0.0061
Schistosoma mansoni neurotransmitter gated ion channel 0.008 0.0428 0.0626
Echinococcus multilocularis sex peptide receptor 0.0026 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0039 0.0176 0.0289
Schistosoma mansoni ran 0.0022 0.0072 0.0105
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0014 0.002
Schistosoma mansoni myosin xvIII 0.0026 0.0093 0.0136
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0093 0.0151
Echinococcus multilocularis Aminotransferase class III 0.0196 0.1146 0.1146
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.008
Loa Loa (eye worm) hypothetical protein 0.018 0.1047 0.1731
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0033 0.072
Echinococcus multilocularis expressed protein 0.0019 0.005 0.005
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0196 0.1146 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0093 0.0093
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.024 0.202
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0173 0.1003 0.1658
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0173 0.1003 0.1658
Schistosoma mansoni survival motor neuron protein 0.005 0.0246 0.0359
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0093 0.0136
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0102 0.2922
Echinococcus granulosus Aminotransferase class III 0.0196 0.1146 0.1677
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0019 0.005 0.0074
Brugia malayi Pre-SET motif family protein 0.0061 0.031 0.0511
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0325 0.0476
Echinococcus multilocularis mothers against decapentaplegic 6 0.0027 0.01 0.01
Giardia lamblia DINP protein human, muc B family 0.0039 0.0176 0.5312
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Brugia malayi jmjC domain containing protein 0.0063 0.0325 0.0536
Schistosoma mansoni hypothetical protein 0.0026 0.0093 0.0136
Brugia malayi MH2 domain containing protein 0.006 0.0304 0.0501
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0434 0.2609 0.3816
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0061 0.0098
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0061 0.0089
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0063 0.0323 1
Onchocerca volvulus 0.0093 0.051 0.0824
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0061 0.0078
Schistosoma mansoni cript-related 0.0013 0.0014 0.002
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0013 0.0014 0.002
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0019 0.005 0.008
Schistosoma mansoni lipoxygenase 0.0114 0.0641 0.0937
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0014
Brugia malayi Dopamine receptor protein 1 0.0026 0.0093 0.0151
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0013 0.0018
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0093 0.0136
Schistosoma mansoni nocturnin 0.0013 0.0014 0.002
Schistosoma mansoni opsin-like receptor 0.0026 0.0093 0.0136
Echinococcus granulosus neutral sphingomyelinase 0.0013 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.008
Brugia malayi hypothetical protein 0.0019 0.0053 0.0085
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0036 0.0836
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0093 0.0136
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0063 0.0323 0.2752
Echinococcus multilocularis deoxyribonuclease 1 2 0.0013 0.0014 0.0014
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.01 0.0163
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Brugia malayi MH1 domain containing protein 0.0033 0.0139 0.0228
Brugia malayi MH1 domain containing protein 0.006 0.0304 0.0501
Loa Loa (eye worm) hypothetical protein 0.008 0.0428 0.0706
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Schistosoma mansoni nAChR subunit 0.008 0.0428 0.0626
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0098
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0294 0.2498
Brugia malayi latrophilin 2 splice variant baaae 0.0339 0.2026 0.3352
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0013 0.0014 0.002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.042 0.2523 0.4176
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0036 0.0036
Trypanosoma cruzi mitochondrial protein 99, putative 0.0013 0.0014 0.0111
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0088 0.1328
Brugia malayi putative neuropeptide receptor 0.0026 0.0093 0.0151
Echinococcus multilocularis smad 0.006 0.0304 0.0304
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0033 0.072
Loa Loa (eye worm) hypothetical protein 0.0093 0.051 0.0842
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0013 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0057
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0176 0.2906
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0014 0.0111
Schistosoma mansoni loxhd1 0.0019 0.0053 0.0078
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0294 0.2498
Brugia malayi Pax transcription factor protein 2 0.0474 0.2858 0.4731
Onchocerca volvulus 0.002 0.0061 0.0078
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0036 0.0836
Loa Loa (eye worm) hypothetical protein 0.0093 0.051 0.0842
Leishmania major RNA-editing complex protein MP100, putative 0.0013 0.0014 0.0111
Loa Loa (eye worm) hypothetical protein 0.0093 0.051 0.0842
Echinococcus multilocularis somatostatin receptor 0.0026 0.0093 0.0093
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0093 0.0136
Schistosoma mansoni hypothetical protein 0.0157 0.0903 0.1321
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Echinococcus granulosus allatostatin A receptor 0.0026 0.0093 0.0136
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.043 0.2583 0.3778
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0033 0.0198
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.024 0.0268
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0093 0.051 0.0746
Mycobacterium tuberculosis Probable aminotransferase 0.1382 0.8453 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0061 0.0089
Brugia malayi hypothetical protein 0.0026 0.0093 0.0151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0061 0.0098
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.008 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Schistosoma mansoni carbon catabolite repressor protein 0.0013 0.0014 0.002
Schistosoma mansoni nAChR subunit 0.0173 0.1003 0.1466
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0048 0.007
Onchocerca volvulus 0.0026 0.0093 0.0132
Loa Loa (eye worm) hypothetical protein 0.0093 0.051 0.0842
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0093 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0088 0.0143
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0019 0.005 0.008
Loa Loa (eye worm) hypothetical protein 0.0103 0.0573 0.0947
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0176 0.5312
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0019 0.005 0.0043
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0061 0.0098
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0063 0.0323 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0173 0.1003 0.1658
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0019 0.005 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0157 0.0903 0.1493
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0093 0.0136
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0036 0.0053
Echinococcus granulosus dna polymerase eta 0.0039 0.0176 0.0258
Loa Loa (eye worm) hypothetical protein 0.0173 0.1003 0.1658
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0075 0.1991
Brugia malayi Cation transporter family protein 0.0173 0.1003 0.1658
Brugia malayi polk-prov protein 0.0012 0.001 0.0014
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0325 0.0476
Mycobacterium ulcerans hypothetical protein 0.0025 0.0088 0.0092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0151
Entamoeba histolytica G protein alpha subunit, putative 0.0019 0.005 0.0655
Onchocerca volvulus 0.0176 0.1023 0.1674
Schistosoma mansoni DNA polymerase eta 0.0039 0.0176 0.0258
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0061 0.0098
Schistosoma mansoni opsin-like receptor 0.0026 0.0093 0.0136
Echinococcus granulosus glycine receptor subunit alpha 1 0.0173 0.1003 0.1466
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0093 0.0136
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0063 0.0323 0.0323
Giardia lamblia hypothetical protein 0.0013 0.0014 0.0111
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0013 0.0014 0.0111
Entamoeba histolytica hypothetical protein 0.0038 0.0167 0.2738

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Toxicity in CD1 mouse assessed as hyperactivity at 3.3 umol/kg, iv ChEMBL. 18605717
Activity (ADMET) Toxicity in CD1 mouse assessed as seizures at 6.7 umol/kg, iv ChEMBL. 18605717
Activity (ADMET) Toxicity in CD1 mouse assessed as circling behavior at 0.8 umol/kg, iv ChEMBL. 18605717
Activity (ADMET) Toxicity in CD1 mouse assessed as straub tail response at 1.7 umol/kg, iv ChEMBL. 18605717
Activity (ADMET) Toxicity in CD1 mouse assessed as straub tail response at 0.8 umol/kg, iv ChEMBL. 18605717
Activity (ADMET) Toxicity in CD1 mouse assessed as circling behavior at 1.7 umol/kg, iv ChEMBL. 18605717
Activity (ADMET) Toxicity in CD1 mouse assessed as straub tail response at 6.7 umol/kg, iv ChEMBL. 18605717
Activity (ADMET) Toxicity in CD1 mouse assessed as straub tail response at 3.3 umol/kg, iv ChEMBL. 18605717
Ki (binding) = 1.33 nM Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK293 cells ChEMBL. 18605717
Ki (binding) = 1.44 nM Displacement of [3H]epibatidine from rat alpha2beta2 nAChR expressed in HEK293 cells ChEMBL. 18605717
Ki (binding) = 3.02 nM Displacement of [3H]epibatidine from rat alpha3beta2 nAChR expressed in HEK293 cells ChEMBL. 18605717
Ki (binding) = 181 nM Displacement of [3H]epibatidine from rat alpha2beta4 nAChR expressed in HEK293 cells ChEMBL. 18605717
Ki (binding) = 188 nM Displacement of [3H]epibatidine from rat alpha4beta4 nAChR expressed in HEK293 cells ChEMBL. 18605717
Ki (binding) = 3680 nM Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK293 cells ChEMBL. 18605717
t1/2 (ADMET) Half life in human thalamus ChEMBL. 18605717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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