Detailed information for compound 954514

Basic information

Technical information
  • TDR Targets ID: 954514
  • Name: 4-(4-methoxyphenyl)sulfanylpyridine
  • MW: 217.287 | Formula: C12H11NOS
  • H donors: 0 H acceptors: 1 LogP: 2.89 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Sc1ccncc1
  • InChi: 1S/C12H11NOS/c1-14-10-2-4-11(5-3-10)15-12-6-8-13-9-7-12/h2-9H,1H3
  • InChiKey: WAITYPKQAOGMIE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(4-methoxyphenyl)thio]pyridine
  • AIDS091496
  • 4-(4-Methoxybenzenethio)-pyridine
  • AIDS-091496

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis pyruvate kinase 0.0027 0.0048 0.0047
Loa Loa (eye worm) deoxynucleoside kinase 0.0666 0.2206 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0068 0.0184 0.4005
Loa Loa (eye worm) Notch2 0.0045 0.0106 0.0481
Trypanosoma brucei calpain, putative 0.0021 0.0027 0.0504
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0021 0.0027 0.0059
Schistosoma mansoni calpain-2 (C02 family) 0.0021 0.0027 0.0027
Loa Loa (eye worm) animal heme peroxidase 0.0279 0.0898 0.407
Schistosoma mansoni hypothetical protein 0.0021 0.0027 0.0027
Leishmania major aldo-keto reductase-like protein 0.0025 0.004 0.079
Loa Loa (eye worm) pyruvate kinase 0.0027 0.0048 0.0214
Echinococcus granulosus histone acetyltransferase KAT2B 0.0039 0.0088 0.0088
Mycobacterium tuberculosis Probable hydrolase 0.0029 0.0054 0.0685
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0021 0.0027 0.0504
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0076 0.0213 0.0212
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0029 0.0054 0.0685
Loa Loa (eye worm) calpain 5 0.0049 0.0122 0.055
Brugia malayi Doublecortin family protein 0.0018 0.0017 0.0075
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Loa Loa (eye worm) oxidoreductase 0.0025 0.004 0.0179
Schistosoma mansoni calpain (C02 family) 0.007 0.0193 0.0193
Loa Loa (eye worm) acetyltransferase 0.0133 0.0406 0.1838
Toxoplasma gondii cytochrome p450 superfamily protein 0.0016 0.0009 0.0208
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Onchocerca volvulus 0.0045 0.0106 0.0532
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0061 0.0322
Toxoplasma gondii MAPEG family protein 0.0072 0.0198 0.4371
Loa Loa (eye worm) 6-phosphofructokinase 0.0089 0.0255 0.1156
Echinococcus multilocularis neurogenic locus notch protein 0.0045 0.0106 0.0106
Trichomonas vaginalis aldo-keto reductase, putative 0.0025 0.004 0.0117
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Echinococcus multilocularis RUN 0.0018 0.0017 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0052 0.1055
Onchocerca volvulus 0.0029 0.0054 0.0268
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0504
Echinococcus granulosus microsomal glutathione S transferase 3 0.0072 0.0198 0.0198
Toxoplasma gondii ABC1 family protein 0.0029 0.0054 0.119
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0022 0.0029 0.054
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0666 0.2206 0.2205
Entamoeba histolytica hypothetical protein 0.0666 0.2206 1
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0009 0.0112
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0021 0.0027 0.0504
Schistosoma mansoni lamin 0.0065 0.0175 0.0174
Entamoeba histolytica aldose reductase, putative 0.0025 0.004 0.0117
Echinococcus granulosus lamin dm0 0.0065 0.0175 0.0174
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0018
Schistosoma mansoni protein phosphatase 2C 0.0014 0.0004 0.0004
Brugia malayi EGF-like domain containing protein 0.0045 0.0106 0.0481
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0029 0.0054 0.0243
Trichomonas vaginalis aldo-keto reductase, putative 0.0025 0.004 0.0117
Toxoplasma gondii aldose reductase, putative 0.0025 0.004 0.088
Loa Loa (eye worm) hypothetical protein 0.0116 0.0347 0.1573
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0028 0.0052 0.0363
Mycobacterium ulcerans lipase LipD 0.0029 0.0054 0.0279
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Echinococcus multilocularis neurogenic locus protein delta 0.0045 0.0106 0.0106
Echinococcus multilocularis calpain A 0.0195 0.0613 0.0613
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0058 0.0151 0.3265
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0186 0.0583 0.8835
Entamoeba histolytica hypothetical protein 0.0666 0.2206 1
Echinococcus multilocularis musashi 0.0065 0.0175 0.0174
Entamoeba histolytica hypothetical protein 0.0033 0.0067 0.0243
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Schistosoma mansoni 6-phosphofructokinase 0.0089 0.0255 0.0255
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0666 0.2206 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0024 0.0037 0.0798
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0027 0.0048 0.0589
Echinococcus granulosus neural cadherin 0.0045 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0179
Echinococcus granulosus protein jagged 1 0.0045 0.0106 0.0106
Loa Loa (eye worm) TAR-binding protein 0.0052 0.013 0.0587
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0052 0.1055
Plasmodium falciparum histone acetyltransferase GCN5 0.0036 0.0077 0.1648
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0088
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0004 0.0004
Echinococcus granulosus pyruvate kinase 0.0027 0.0048 0.0047
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Trichomonas vaginalis thymidylate kinase, putative 0.0147 0.0453 0.2002
Echinococcus multilocularis pyruvate kinase 0.0027 0.0048 0.0047
Echinococcus multilocularis thymidine kinase 0.2974 1 1
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0009 0.0009
Brugia malayi beta-lactamase 0.0029 0.0054 0.0243
Echinococcus multilocularis thymidine kinase 0.2974 1 1
Toxoplasma gondii pyruvate kinase PyKII 0.0014 0.0003 0.0064
Schistosoma mansoni calpain C (C02 family) 0.007 0.0193 0.0193
Entamoeba histolytica hypothetical protein 0.0033 0.0067 0.0243
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0029 0.0054 0.0243
Trichomonas vaginalis aldo-keto reductase, putative 0.0025 0.004 0.0117
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0039 0.0088 0.1945
Entamoeba histolytica hypothetical protein 0.0666 0.2206 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0025 0.004 0.0117
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0045 0.0106 0.0106
Schistosoma mansoni jumonji domain containing protein 0.0014 0.0004 0.0004
Trypanosoma cruzi thymidylate kinase, putative 0.0147 0.0453 1
Brugia malayi calpain 5 0.0049 0.0122 0.055
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Echinococcus multilocularis peroxidasin 0.0279 0.0898 0.0898
Entamoeba histolytica aldose reductase, putative 0.0025 0.004 0.0117
Onchocerca volvulus 0.0045 0.0106 0.0532
Trichomonas vaginalis calpain, putative 0.0021 0.0027 0.0059
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0025 0.004 0.0039
Onchocerca volvulus Pyruvate kinase homolog 0.0027 0.0048 0.0237
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0067 0.0067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0052 0.1055
Schistosoma mansoni 6-phosphofructokinase 0.0089 0.0255 0.0255
Echinococcus granulosus peroxidasin 0.0279 0.0898 0.0898
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0133 0.0406 0.0405
Echinococcus multilocularis phd:f box containing protein 0.0014 0.0004 0.0004
Loa Loa (eye worm) animal heme peroxidase 0.0279 0.0898 0.407
Onchocerca volvulus 0.0029 0.0054 0.0268
Schistosoma mansoni tar DNA-binding protein 0.0052 0.013 0.0129
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.0009 0.0112
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0089 0.0255 0.3788
Brugia malayi notch-like transmembrane receptor 0.0045 0.0106 0.0481
Mycobacterium leprae Probable lipase LipE 0.0029 0.0054 0.0685
Brugia malayi 6-phosphofructokinase 0.0089 0.0255 0.1156
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0052 0.1055
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0025 0.004 0.0117
Echinococcus granulosus protein jagged 1 0.0045 0.0106 0.0106
Leishmania major cytochrome p450-like protein 0.0016 0.0009 0.0112
Schistosoma mansoni hypothetical protein 0.0035 0.0075 0.0074
Echinococcus granulosus protein jagged 2 0.0045 0.0106 0.0106
Trichomonas vaginalis pyruvate kinase, putative 0.0027 0.0048 0.0153
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.003
Trypanosoma cruzi aldo-keto reductase 0.0025 0.004 0.079
Brugia malayi EGF-like domain containing protein 0.0045 0.0106 0.0481
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.007 0.0193 0.4203
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0504
Mycobacterium tuberculosis Conserved protein 0.0029 0.0054 0.0685
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0028 0.0052 0.1055
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0068 0.0184 0.0775
Echinococcus multilocularis pyruvate kinase 0.0014 0.0003 0.0003
Loa Loa (eye worm) blistered cuticle protein 3 0.0279 0.0898 0.407
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0039 0.0088 0.0337
Echinococcus multilocularis transfer RNA-Ile 0.2974 1 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0028 0.0052 0.0266
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0014 0.0216
Echinococcus multilocularis JmjC domain containing protein 4 0.0014 0.0004 0.0004
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0028 0.0052 0.1055
Toxoplasma gondii 6-phosphofructokinase 0.0024 0.0037 0.0809
Trichomonas vaginalis calpain, putative 0.0021 0.0027 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0666 0.2206 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0025 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0137 0.0419 0.1896
Onchocerca volvulus 0.0018 0.0017 0.0083
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0243
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0054 0.0138 0.0138
Plasmodium falciparum thioredoxin reductase 0.0082 0.0233 0.511
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0021 0.0027 0.0504
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0028 0.0052 0.0051
Trypanosoma cruzi trypanothione reductase, putative 0.0082 0.0233 0.5094
Trichomonas vaginalis phosphofructokinase, putative 0.0089 0.0255 0.11
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.007 0.0193 0.4203
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0025 0.004 0.0179
Echinococcus multilocularis calpain 0.007 0.0193 0.0193
Loa Loa (eye worm) doublecortin family protein 0.0018 0.0017 0.0075
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0147 0.0453 0.6833
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0021 0.0027 0.0597
Schistosoma mansoni tar DNA-binding protein 0.0052 0.013 0.0129
Onchocerca volvulus 0.0025 0.004 0.0198
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0026 0.0117
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0051 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0165 0.0513 0.2325
Toxoplasma gondii hypothetical protein 0.0021 0.0027 0.0597
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0052 0.0858
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0187 0.0588 0.8913
Schistosoma mansoni pyruvate kinase 0.0027 0.0048 0.0047
Echinococcus granulosus aldo keto reductase 0.0025 0.004 0.0039
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0068 0.0184 0.0184
Trypanosoma brucei Calpain-like protein 2 0.0021 0.0027 0.0504
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Onchocerca volvulus 0.0279 0.0898 0.45
Echinococcus granulosus 6 phosphofructokinase 0.0089 0.0255 0.0255
Brugia malayi Animal haem peroxidase family protein 0.0279 0.0898 0.407
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0022 0.0036
Schistosoma mansoni phosphatidylserine receptor 0.0014 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0666 0.2206 1
Echinococcus granulosus delta-like protein 1 0.0045 0.0106 0.0106
Echinococcus granulosus ubiquitin specific protease 41 0.0068 0.0184 0.0184
Onchocerca volvulus Peroxidasin homolog 0.0279 0.0898 0.45
Brugia malayi Deoxynucleoside kinase family protein 0.0666 0.2206 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0009 0.0112
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0138 0.0626
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Schistosoma mansoni ankyrin 23/unc44 0.0013 0 0.000000013352
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0076 0.0213 0.0212
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0128 0.0578
Brugia malayi thymidylate kinase 0.0147 0.0453 0.2052
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Onchocerca volvulus Peroxidase homolog 0.0279 0.0898 0.45
Schistosoma mansoni glutaminase 0.0488 0.1602 0.1602
Trichomonas vaginalis bromodomain-containing protein, putative 0.0039 0.0088 0.0337
Entamoeba histolytica phosphofructokinase, putative 0.0089 0.0255 0.11
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0037 0.0103
Echinococcus granulosus histone acetyltransferase KAT2B 0.013 0.0393 0.0393
Onchocerca volvulus 0.0279 0.0898 0.45
Echinococcus granulosus lysine specific demethylase 5A 0.0054 0.0138 0.0138
Plasmodium falciparum thymidylate kinase 0.0147 0.0453 1
Trypanosoma brucei antigen, putative 0.007 0.0193 0.4203
Entamoeba histolytica pyruvate kinase, putative 0.0019 0.002 0.0026
Brugia malayi jmjC domain containing protein 0.0014 0.0004 0.0018
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0061 0.1257
Giardia lamblia Deoxynucleoside kinase 0.0666 0.2206 1
Entamoeba histolytica hypothetical protein 0.0666 0.2206 1
Brugia malayi jmjC domain containing protein 0.0014 0.0004 0.0018
Brugia malayi Peroxidasin 0.0279 0.0898 0.407
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0208 0.0658 1
Echinococcus granulosus hypothetical protein 0.0025 0.004 0.0039
Plasmodium falciparum pyruvate kinase 0.0027 0.0048 0.0994
Plasmodium vivax JmjC domain containing protein 0.0014 0.0004 0.0086
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0089 0.0255 0.5593
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0024 0.0037 0.0809
Brugia malayi Pyruvate kinase, M2 isozyme 0.0027 0.0048 0.0214
Echinococcus multilocularis thymidylate kinase 0.0147 0.0453 0.0452
Plasmodium falciparum glutathione reductase 0.0082 0.0233 0.511
Mycobacterium ulcerans esterase/lipase LipP 0.0029 0.0054 0.0279
Brugia malayi Intermediate filament tail domain containing protein 0.0065 0.0175 0.0791
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0017 0.0017
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.007 0.0193 0.4203
Schistosoma mansoni hypothetical protein 0.0573 0.189 0.189
Leishmania major hypothetical protein, conserved 0.0058 0.0151 0.3265
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0071 0.0197 0.0197
Treponema pallidum thymidylate kinase (tmk) 0.0147 0.0453 1
Echinococcus multilocularis protein jagged 2 0.0045 0.0106 0.0106
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0187 0.0588 0.8913
Echinococcus granulosus geminin 0.0573 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.007 0.0193 0.4203
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0089 0.0255 0.11
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0061 0.1257
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0028 0.0052 0.1055
Brugia malayi glutathione reductase 0.0082 0.0233 0.1054
Loa Loa (eye worm) calpain family protein 1 0.0186 0.0584 0.2648
Brugia malayi Pre-SET motif family protein 0.0531 0.1747 0.7922
Brugia malayi Animal haem peroxidase family protein 0.0279 0.0898 0.407
Echinococcus granulosus RUN 0.0018 0.0017 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0052 0.013 0.0129
Entamoeba histolytica phosphofructokinase, putative 0.0089 0.0255 0.11
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0017 0.0017
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.007 0.0193 0.4203
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0071 0.0197 0.0892
Plasmodium vivax 6-phosphofructokinase, putative 0.0024 0.0037 0.0798
Onchocerca volvulus Peroxidasin homolog 0.0279 0.0898 0.45
Echinococcus granulosus bloom syndrome protein 0.002 0.0022 0.0022
Onchocerca volvulus Putative thymidylate kinase 0.0147 0.0453 0.2268
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0037 0.0103
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0017 0.0014 0.0051
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0031 0.0061 0.0061
Echinococcus granulosus phd:f box containing protein 0.0014 0.0004 0.0004
Plasmodium vivax pyruvate kinase, putative 0.0027 0.0048 0.1042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0071 0.0197 0.0197
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.007 0.0193 0.4203
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0068 0.0184 0.0833
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.0213 0.0212
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0054 0.0054
Plasmodium vivax multidomain scavenger receptor, putative 0.0018 0.0017 0.0363
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0071 0.0197 0.0892
Loa Loa (eye worm) RecQ helicase 0.002 0.0022 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0666 0.2206 1
Leishmania major calpain family cysteine protease-like protein 0.0021 0.0027 0.0504
Giardia lamblia NADH oxidase lateral transfer candidate 0.0028 0.0052 0.0222
Echinococcus granulosus nuclear factor of activated T cells 5 0.0068 0.0184 0.0184
Brugia malayi RNA recognition motif domain containing protein 0.0052 0.013 0.0587
Echinococcus multilocularis Polycystic kidney disease protein 0.0018 0.0017 0.0017
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0666 0.2206 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0025 0.004 0.0117
Schistosoma mansoni pol-related 0.0025 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0243
Toxoplasma gondii pyruvate kinase PyK1 0.0027 0.0048 0.1052
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.2974 1 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Brugia malayi GCC2 and GCC3 family protein 0.0045 0.0106 0.0481
Echinococcus granulosus thioredoxin glutathione reductase 0.0082 0.0233 0.0232
Schistosoma mansoni notch 0.0045 0.0106 0.0106
Trichomonas vaginalis aldo-keto reductase, putative 0.0025 0.004 0.0117
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0017 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0054 0.0181
Brugia malayi Animal haem peroxidase family protein 0.0279 0.0898 0.407
Plasmodium falciparum JmjC domain-containing protein, putative 0.0014 0.0004 0.0034
Echinococcus granulosus protein jagged 2 0.0045 0.0106 0.0106
Loa Loa (eye worm) glutaminase 2 0.0488 0.1602 0.7264
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0025 0.004 0.0039
Toxoplasma gondii NADPH-glutathione reductase 0.0028 0.0052 0.1143
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0186 0.0584 0.0584
Loa Loa (eye worm) intermediate filament protein 0.0065 0.0175 0.0791
Brugia malayi Death domain containing protein 0.0013 0 0.000000060545
Brugia malayi hypothetical protein 0.0018 0.0017 0.0075
Trypanosoma brucei calpain-like protein, putative 0.007 0.0193 0.4203
Mycobacterium tuberculosis Conserved protein 0.0029 0.0054 0.0685
Trichomonas vaginalis conserved hypothetical protein 0.0666 0.2206 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0027 0.0048 0.0589
Onchocerca volvulus 0.0045 0.0106 0.0532
Schistosoma mansoni Mername-AA248 (C02 family) 0.007 0.0193 0.0193
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Onchocerca volvulus Slit protein homolog 0.0045 0.0106 0.0532
Brugia malayi acetyltransferase, GNAT family protein 0.0133 0.0406 0.1838
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0052 0.013 0.0587
Schistosoma mansoni loxhd1 0.0018 0.0017 0.0017
Entamoeba histolytica Thymidylate kinase, putative 0.0147 0.0453 0.2002
Loa Loa (eye worm) hypothetical protein 0.0186 0.0584 0.2648
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0208 0.0658 1
Schistosoma mansoni peroxidasin 0.0279 0.0898 0.0898
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0015 0.0093
Leishmania major kinesin, putative 0.0049 0.0122 0.2613
Trichomonas vaginalis glutaminase, putative 0.0488 0.1602 0.7247
Trypanosoma brucei pyruvate kinase 1, putative 0.0027 0.0048 0.0964
Giardia lamblia Hypothetical protein 0.0666 0.2206 1
Schistosoma mansoni notch 0.0045 0.0107 0.0106
Mycobacterium tuberculosis Conserved protein 0.0029 0.0054 0.0685
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0071 0.0197 0.0197
Echinococcus granulosus aldo keto reductase 0.0025 0.004 0.0039
Mycobacterium ulcerans hypothetical protein 0.0029 0.0054 0.0279
Echinococcus multilocularis pyruvate kinase 0.0021 0.0028 0.0028
Giardia lamblia High cysteine protein 0.0045 0.0106 0.047
Brugia malayi Uncoordinated protein 44 0.0013 0 0.000000060545
Giardia lamblia Aldose reductase 0.0025 0.004 0.0168
Onchocerca volvulus Neurogenic locus notch homolog 0.0045 0.0107 0.0534
Brugia malayi Delta serrate ligand family protein 0.0045 0.0106 0.0481
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Onchocerca volvulus 0.0025 0.004 0.0198
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.0014 0.0072
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.0052 0.1055
Brugia malayi hypothetical protein 0.0018 0.0017 0.0075
Echinococcus multilocularis aldo keto reductase 0.0025 0.004 0.0039
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0052 0.0858
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0004 0.0018
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0028 0.0052 0.0266
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0028 0.0052 0.1086
Trichomonas vaginalis aldo-keto reductase, putative 0.0025 0.004 0.0117
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0028 0.0052 0.0051
Leishmania major hypothetical protein, conserved 0.0021 0.0027 0.0504
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0052 0.1055
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0014 0.0062
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0014 0.0004 0.0098
Echinococcus multilocularis lamin dm0 0.0065 0.0175 0.0174
Echinococcus granulosus calpain 5 0.007 0.0193 0.0193
Trichomonas vaginalis mercuric reductase, putative 0.0028 0.0052 0.0172
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0052 0.1055
Onchocerca volvulus 0.0076 0.0213 0.1064
Echinococcus granulosus pyruvate kinase 0.0027 0.0048 0.0047
Echinococcus granulosus lysine specific demethylase 6a 0.0014 0.0004 0.0004
Echinococcus multilocularis neurogenic locus notch protein 0.0045 0.0106 0.0106
Schistosoma mansoni ap endonuclease 0.0017 0.0014 0.0014
Giardia lamblia Pyruvate kinase 0.0027 0.0048 0.0203
Toxoplasma gondii EGF family domain-containing protein 0.0045 0.0106 0.235
Echinococcus multilocularis protein jagged 1 0.0045 0.0106 0.0106
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0068 0.0184 0.4005
Onchocerca volvulus 0.0065 0.0175 0.0874
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Loa Loa (eye worm) notch protein 0.0045 0.0106 0.0481
Entamoeba histolytica calpain family cysteine protease, putative 0.0021 0.0027 0.0059
Trichomonas vaginalis aldo-keto reductase, putative 0.0025 0.004 0.0117
Brugia malayi beta-lactamase family protein 0.0029 0.0054 0.0243
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0068 0.0184 0.0775
Brugia malayi calpain family protein 1 0.0186 0.0584 0.2648
Entamoeba histolytica hypothetical protein 0.0666 0.2206 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0014 0.0014
Brugia malayi glutaminase DH11.1 0.0488 0.1602 0.7264
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0068 0.0184 0.0184
Trypanosoma brucei cysteine peptidase, putative 0.0021 0.0027 0.0504
Trichomonas vaginalis glutathione reductase, putative 0.0028 0.0052 0.0172
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0666 0.2206 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0277
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0021 0.0027 0.0059
Brugia malayi Cytochrome P450 family protein 0.0016 0.0009 0.0041
Mycobacterium tuberculosis Probable dehydrogenase 0.0187 0.0588 0.8913
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0214
Mycobacterium ulcerans thymidylate kinase 0.0147 0.0453 0.2784
Echinococcus multilocularis neural cadherin 0.0045 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Trypanosoma brucei Calpain-like protein CALP1.3 0.0021 0.0027 0.0504
Brugia malayi Cytochrome P450 family protein 0.0051 0.0128 0.0578
Echinococcus granulosus lamin 0.0065 0.0175 0.0174
Onchocerca volvulus 0.0025 0.004 0.0198
Onchocerca volvulus 0.0065 0.0175 0.0874
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0184 0.0775
Echinococcus granulosus thymidine kinase 0.2974 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Loa Loa (eye worm) hypothetical protein 0.0292 0.0941 0.4264
Trypanosoma brucei aldo-keto reductase, putative 0.0025 0.004 0.079
Mycobacterium ulcerans beta-lactamase 0.0029 0.0054 0.0279
Schistosoma mansoni laminin gamma-3 chain 0.0045 0.0106 0.0106
Schistosoma mansoni peroxidasin 0.0279 0.0898 0.0898
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0025 0.004 0.079
Trichomonas vaginalis aldo-keto reductase, putative 0.0025 0.004 0.0117
Trichomonas vaginalis aldo-keto reductase, putative 0.0025 0.004 0.0117
Schistosoma mansoni hypothetical protein 0.0045 0.0106 0.0106
Echinococcus multilocularis bloom syndrome protein 0.002 0.0022 0.0022
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0014 0.0014
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0666 0.2206 0.2205
Trypanosoma brucei calpain-like protein, putative 0.007 0.0193 0.4203
Plasmodium vivax calpain, putative 0.007 0.0193 0.4253
Echinococcus granulosus fibropellin Ia 0.0045 0.0106 0.0106
Plasmodium vivax glutathione reductase, putative 0.0082 0.0233 0.5136
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0028 0.0052 0.1086
Schistosoma mansoni jumonji/arid domain-containing protein 0.0054 0.0138 0.0138
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0037 0.0103
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0045 0.0106 0.0532
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0028 0.0052 0.1143
Echinococcus multilocularis calpain family protein 1, d 0.0137 0.0419 0.0418
Brugia malayi TAR-binding protein 0.0052 0.013 0.0587
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0061 0.0274
Mycobacterium ulcerans glutaminase 0.0488 0.1602 1
Onchocerca volvulus 0.0279 0.0898 0.45
Echinococcus granulosus aldehyde reductase 0.0018 0.0015 0.0015
Brugia malayi hypothetical protein 0.0112 0.0334 0.1511
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0068 0.0184 0.0184
Brugia malayi Cadherin domain containing protein 0.0045 0.0106 0.0481
Brugia malayi Cytochrome P450 family protein 0.0031 0.0061 0.0274
Echinococcus granulosus pyruvate kinase 0.0014 0.0003 0.0003
Trichomonas vaginalis aldo-keto reductase, putative 0.0025 0.004 0.0117
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0025 0.004 0.079
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0068 0.0184 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0071 0.0197 0.0197
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0025 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Brugia malayi calpain D 0.0021 0.0027 0.0121
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0068 0.0184 0.0822
Schistosoma mansoni ap endonuclease 0.0017 0.0014 0.0014
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0133 0.0406 0.0405
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0025 0.004 0.0039
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0035 0.0073 0.033
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.0009 0.0112
Trichomonas vaginalis hypothetical protein 0.0021 0.0027 0.0059
Schistosoma mansoni aldo-keto reductase 0.0025 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Brugia malayi jmjC domain containing protein 0.0014 0.0004 0.0018
Loa Loa (eye worm) calpain 0.007 0.0193 0.0873
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0021 0.0027 0.0059
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0089 0.0255 0.3788
Loa Loa (eye worm) hypothetical protein 0.0068 0.0184 0.0833
Trypanosoma cruzi calpain cysteine peptidase, putative 0.007 0.0193 0.4203
Schistosoma mansoni hypothetical protein 0.0016 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0021 0.0027 0.0059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0121
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0666 0.2206 0.2205
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0014 0.0004 0.0098
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0067 0.0067
Onchocerca volvulus Peroxidase homolog 0.0279 0.0898 0.45
Entamoeba histolytica hypothetical protein 0.0033 0.0067 0.0243
Loa Loa (eye worm) pyruvate kinase 0.0027 0.0048 0.0214
Trypanosoma cruzi thymidylate kinase, putative 0.0147 0.0453 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0025 0.004 0.0117
Brugia malayi calpain 7 0.007 0.0193 0.0873
Onchocerca volvulus 0.0025 0.004 0.0198
Entamoeba histolytica hypothetical protein 0.0666 0.2206 1
Brugia malayi calpain family protein 1 0.0186 0.0584 0.2648
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0073 0.0203 0.0203
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0025 0.004 0.0039
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0014 0.0004 0.0004
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0028 0.0052 0.1055
Trypanosoma cruzi pyruvate kinase 2, putative 0.0027 0.0048 0.0964
Trypanosoma brucei thymidylate kinase, putative 0.0147 0.0453 1
Brugia malayi cytochrome P450 0.0016 0.0009 0.0041
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0025 0.004 0.0039
Plasmodium vivax pyruvate kinase 2, putative 0.0014 0.0003 0.0053
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0061 0.0274
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0072 0.0198 0.0198
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0068 0.0184 0.0184
Echinococcus granulosus neurogenic locus protein delta 0.0045 0.0106 0.0106
Trichomonas vaginalis phosphofructokinase, putative 0.0089 0.0255 0.11
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0021 0.0027 0.0504
Trypanosoma brucei trypanothione reductase 0.0082 0.0233 0.5094
Schistosoma mansoni tar DNA-binding protein 0.0052 0.013 0.0129
Echinococcus multilocularis neurogenic locus notch protein 4 0.0045 0.0106 0.0106
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0025 0.004 0.0179
Schistosoma mansoni polycystin 1-related 0.0018 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0573 0.189 0.189
Plasmodium falciparum LCCL domain-containing protein 0.0018 0.0017 0.0312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Loa Loa (eye worm) oxidoreductase 0.0025 0.004 0.0179
Brugia malayi calpain 5 0.0021 0.0027 0.0121
Loa Loa (eye worm) RNA binding protein 0.0052 0.013 0.0587
Plasmodium falciparum glutathione reductase 0.0028 0.0052 0.1086
Brugia malayi EGF-like domain containing protein 0.0045 0.0106 0.0481
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0028 0.0052 0.0266
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0004 0.0018
Trypanosoma brucei Calpain-like protein 1.2 0.0021 0.0027 0.0504
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0666 0.2206 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0025 0.004 0.0469
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Trichomonas vaginalis thymidylate kinase, putative 0.0147 0.0453 0.2002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Giardia lamblia Histone acetyltransferase GCN5 0.0036 0.0077 0.0337
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0014 0.0062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0054 0.0138 0.0138
Echinococcus multilocularis calpain 5 0.007 0.0193 0.0193
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0504
Echinococcus granulosus neurogenic locus notch protein 4 0.0045 0.0106 0.0106
Echinococcus multilocularis notch 0.0045 0.0106 0.0106
Schistosoma mansoni rab6-interacting 0.0018 0.0017 0.0017
Trypanosoma brucei pyruvate kinase 1 0.0027 0.0048 0.0964
Mycobacterium leprae conserved hypothetical protein 0.0029 0.0054 0.0685
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0039 0.0088 0.1935
Trichomonas vaginalis pyruvate kinase, putative 0.0027 0.0048 0.0153
Brugia malayi hypothetical protein 0.0033 0.0067 0.0304
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0004 0.0004
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Entamoeba histolytica phosphofructokinase, putative 0.0089 0.0255 0.11
Schistosoma mansoni lamin 0.0065 0.0175 0.0174
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0025 0.004 0.0179
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.0017
Trichomonas vaginalis aldo-keto reductase, putative 0.0025 0.004 0.0117
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0045 0.0106 0.0481
Echinococcus granulosus Polycystic kidney disease protein 0.0018 0.0017 0.0017
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0014 0.0029
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0025 0.004 0.0469
Echinococcus granulosus neurogenic locus notch protein 0.0045 0.0106 0.0106
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0025 0.004 0.0117
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Echinococcus multilocularis protein jagged 1 0.0045 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0045 0.0106 0.0106
Echinococcus granulosus tar DNA binding protein 0.0052 0.013 0.0129
Schistosoma mansoni slit 0.0045 0.0106 0.0106
Giardia lamblia Aldose reductase 0.0025 0.004 0.0168
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0504
Echinococcus multilocularis pyruvate kinase 0.0014 0.0003 0.0003
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0195 0.0613 0.0613
Schistosoma mansoni phd/f-box containing protein 0.0014 0.0004 0.0004
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0195 0.0613 0.0613
Brugia malayi Pre-SET motif family protein 0.0076 0.0213 0.0963
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0504
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Schistosoma mansoni cell polarity protein 0.0045 0.0106 0.0106
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0147 0.0453 0.6833
Trypanosoma brucei prostaglandin f synthase 0.0025 0.004 0.079
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0014 0.0249
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0024 0.0037 0.0103
Schistosoma mansoni notch 0.0045 0.0106 0.0106
Loa Loa (eye worm) 6-phosphofructokinase 0.0089 0.0255 0.1156
Brugia malayi cytoplasmic intermediate filament protein 0.0035 0.0073 0.033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0052 0.1055
Brugia malayi intermediate filament protein 0.0065 0.0175 0.0791
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0089 0.0255 0.5496
Loa Loa (eye worm) oxidoreductase 0.0025 0.004 0.0179
Onchocerca volvulus 0.0025 0.004 0.0198
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0027 0.0504
Entamoeba histolytica hypothetical protein 0.0666 0.2206 1
Echinococcus multilocularis aldehyde reductase 0.0018 0.0015 0.0015
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0014 0.0301
Entamoeba histolytica hypothetical protein 0.0666 0.2206 1
Schistosoma mansoni notch 0.0045 0.0106 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0089 0.0255 0.5593
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Leishmania major ATP-dependent phosphofructokinase 0.0089 0.0255 0.5593
Echinococcus multilocularis beta LACTamase domain containing family member 0.0029 0.0054 0.0054
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.0213 0.0212
Brugia malayi EGF-like domain containing protein 0.0045 0.0106 0.0481
Giardia lamblia CDC8 0.0147 0.0453 0.2043
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0068 0.0184 0.0775
Leishmania major trypanothione reductase 0.0082 0.0233 0.5094
Mycobacterium ulcerans pyruvate kinase 0.0027 0.0048 0.024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Onchocerca volvulus Pyruvate kinase homolog 0.0027 0.0048 0.0237
Schistosoma mansoni hypothetical protein 0.0045 0.0106 0.0106
Loa Loa (eye worm) pyruvate kinase 0.0027 0.0048 0.0214
Schistosoma mansoni microsomal glutathione s-transferase 0.0072 0.0198 0.0198
Schistosoma mansoni hypothetical protein 0.0045 0.0106 0.0106
Trypanosoma cruzi kinesin, putative 0.0049 0.0122 0.2613
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.007 0.0193 0.4203
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0054 0.0138 0.0138
Leishmania major pyruvate kinase 0.0027 0.0048 0.0964
Schistosoma mansoni aldo-keto reductase 0.0025 0.004 0.0039
Echinococcus multilocularis pyruvate kinase 0.0014 0.0003 0.0003
Leishmania major cytochrome p450-like protein 0.0016 0.0009 0.0112
Trichomonas vaginalis calpain, putative 0.0021 0.0027 0.0059
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0029 0.0054 0.0685
Leishmania major pyruvate kinase 0.0027 0.0048 0.0964
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0004 0.0018
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0024 0.0037 0.0103
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Brugia malayi jmjC domain containing protein 0.0054 0.0138 0.0626
Schistosoma mansoni hypothetical protein 0.0045 0.0106 0.0106
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0068 0.0184 0.4005
Loa Loa (eye worm) glutathione reductase 0.0082 0.0233 0.1054
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0031 0.0061 0.0061
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.007 0.0193 0.4203
Loa Loa (eye worm) hypothetical protein 0.0076 0.0213 0.0963
Entamoeba histolytica calpain large subunit domain III containing protein 0.0049 0.0122 0.049
Loa Loa (eye worm) phosphofructokinase 0.0089 0.0255 0.1156
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0021 0.0027 0.0059
Onchocerca volvulus 0.0045 0.0106 0.0532
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0054 0.0181
Brugia malayi Calcium binding EGF domain containing protein 0.0045 0.0106 0.0481
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.007 0.0193 0.4203
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Onchocerca volvulus Putative cubilin 0.0045 0.0106 0.0532
Mycobacterium ulcerans oxidoreductase 0.0025 0.004 0.0191
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0024 0.0037 0.075
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Echinococcus granulosus aldo keto reductase 0.0025 0.004 0.0039
Onchocerca volvulus 0.0604 0.1995 1
Brugia malayi Animal haem peroxidase family protein 0.0279 0.0898 0.407
Schistosoma mansoni hypothetical protein 0.0147 0.0453 0.0452
Brugia malayi EGF-like domain containing protein 0.0045 0.0106 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0027 0.0059
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0025 0.004 0.0179
Leishmania major hypothetical protein, conserved 0.0029 0.0054 0.1103
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0068 0.0184 0.0184
Schistosoma mansoni lipoxygenase 0.0018 0.0017 0.0017
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0147 0.0453 1
Echinococcus granulosus calpain 0.007 0.0193 0.0193
Chlamydia trachomatis thymidylate kinase 0.0147 0.0453 1
Echinococcus multilocularis geminin 0.0573 0.189 0.189
Schistosoma mansoni pyruvate kinase 0.0027 0.0048 0.0047
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0187 0.0588 0.8913
Brugia malayi EGF-like domain containing protein 0.0045 0.0106 0.0481
Onchocerca volvulus 0.0045 0.0106 0.0532
Plasmodium falciparum calpain 0.0021 0.0027 0.0536
Loa Loa (eye worm) hypothetical protein 0.0064 0.0171 0.0773
Loa Loa (eye worm) cytochrome P450 0.0016 0.0009 0.0041
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0058 0.0151 0.3265
Trypanosoma brucei calpain-like protein, putative 0.007 0.0193 0.4203
Echinococcus multilocularis lysine specific demethylase 5A 0.0054 0.0138 0.0138
Loa Loa (eye worm) animal heme peroxidase 0.0279 0.0898 0.407
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0054 0.1103
Onchocerca volvulus Pyruvate kinase homolog 0.0027 0.0048 0.0237
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.007 0.0193 0.4203
Echinococcus multilocularis jumonji domain containing 1A 0.0014 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0061 0.0274
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0051 0.0127 0.0127
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0052 0.1055
Plasmodium vivax SET domain protein, putative 0.0076 0.0213 0.4691
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0243
Schistosoma mansoni hypothetical protein 0.0033 0.0067 0.0067
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0195 0.0613 0.0613
Brugia malayi Thioredoxin reductase 0.0082 0.0233 0.1054
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0022 0.0098
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0075
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0025 0.004 0.0039
Echinococcus multilocularis slit 2 protein 0.0045 0.0106 0.0106
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0024 0.0037 0.075
Trypanosoma cruzi aldo/keto reductase, putative 0.0025 0.004 0.079
Brugia malayi EGF-like domain containing protein 0.0045 0.0106 0.0481
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0082 0.0233 0.3443
Plasmodium vivax thioredoxin reductase, putative 0.0082 0.0233 0.5136
Echinococcus granulosus jumonji domain containing 1A 0.0014 0.0004 0.0004
Trichomonas vaginalis aldo/keto reductase, putative 0.0025 0.004 0.0117
Entamoeba histolytica protein kinase, putative 0.0049 0.0122 0.049
Loa Loa (eye worm) oxidoreductase 0.0025 0.004 0.0179
Echinococcus granulosus notch 0.0045 0.0106 0.0106
Echinococcus multilocularis fat cadherin tumor suppressor 0.0045 0.0106 0.0106
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0666 0.2206 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0243
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0016 0.0009 0.0112
Brugia malayi Cytochrome P450 family protein 0.0031 0.0061 0.0274
Schistosoma mansoni notch 0.0045 0.0106 0.0106
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0028 0.0052 0.0652
Brugia malayi Protein kinase domain containing protein 0.0013 0 0.000000060545
Echinococcus multilocularis 6 phosphofructokinase 0.0089 0.0255 0.0255
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0052 0.1055
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0017 0.0014 0.0245
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0054 0.1179
Mycobacterium tuberculosis Probable lipase LipD 0.0029 0.0054 0.0685
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.007 0.0193 0.4203
Mycobacterium tuberculosis Probable esterase LipL 0.0029 0.0054 0.0685
Schistosoma mansoni pyruvate kinase 0.0014 0.0003 0.0003
Trypanosoma brucei calpain, putative 0.0021 0.0027 0.0504
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Brugia malayi Muscle positioning protein 4 0.0045 0.0106 0.0481
Echinococcus multilocularis aldo keto reductase 0.0025 0.004 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0054 0.0181
Loa Loa (eye worm) calpain family protein 1 0.0137 0.0419 0.1896
Onchocerca volvulus Chorion peroxidase homolog 0.0279 0.0898 0.45
Echinococcus multilocularis calpain 7 (C02 family) 0.007 0.0193 0.0193
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0208 0.0658 1
Trypanosoma cruzi conserved protein 0.0021 0.0027 0.0504
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0071 0.0197 0.0197
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0037 0.0103
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.007 0.0193 0.4203
Echinococcus granulosus neurogenic locus notch protein 0.0045 0.0106 0.0106
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.007 0.0193 0.4203
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0025 0.004 0.0039
Echinococcus multilocularis thioredoxin glutathione reductase 0.0082 0.0233 0.0232
Entamoeba histolytica acetyltransferase, GNAT family 0.0036 0.0077 0.0287
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0054 0.1103
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0014 0.0216
Brugia malayi 6-phosphofructokinase 0.0089 0.0255 0.1156
Trichomonas vaginalis conserved hypothetical protein 0.0666 0.2206 1
Echinococcus granulosus slit 2 protein 0.0045 0.0106 0.0106
Onchocerca volvulus 0.0029 0.0054 0.0268
Loa Loa (eye worm) oxidoreductase 0.0025 0.004 0.0179
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Loa Loa (eye worm) beta-lactamase 0.0029 0.0054 0.0243
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0076 0.0213 0.4697
Echinococcus multilocularis tar DNA binding protein 0.0052 0.013 0.0129
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0025 0.004 0.0039
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0025 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0018
Echinococcus multilocularis lysine specific demethylase 6a 0.0014 0.0004 0.0004
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0187 0.0588 0.8913
Loa Loa (eye worm) hypothetical protein 0.0065 0.0175 0.0791
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0075
Schistosoma mansoni hypothetical protein 0.0045 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0025 0.004 0.0039
Treponema pallidum NADH oxidase 0.0028 0.0052 0.0858
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0531 0.1747 0.7922
Toxoplasma gondii exonuclease III APE 0.0017 0.0014 0.0312
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0025 0.004 0.0117
Echinococcus multilocularis ubiquitin specific protease 41 0.0068 0.0184 0.0184
Schistosoma mansoni cytochrome P450 0.0016 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0033 0.0067 0.0243
Trypanosoma brucei thymidylate kinase, putative 0.0147 0.0453 1
Schistosoma mansoni jumonji domain containing protein 0.0054 0.0138 0.0138
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0054 0.1103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0071 0.0197 0.0197
Trichomonas vaginalis phosphofructokinase, putative 0.0089 0.0255 0.11
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0025 0.004 0.0039
Loa Loa (eye worm) glutaminase 0.0488 0.1602 0.7264
Schistosoma mansoni calpain-7 (C02 family) 0.0076 0.0211 0.0211
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0013 0 0.000000013352
Echinococcus multilocularis fibropellin Ia 0.0045 0.0106 0.0106
Echinococcus granulosus thymidylate kinase 0.0147 0.0453 0.0452
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0052 0.1055
Leishmania major thymidylate kinase-like protein 0.0147 0.0453 1
Brugia malayi Cadherin domain containing protein 0.0045 0.0106 0.0481
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0013 0 0.000000013352
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Entamoeba histolytica aldose reductase, putative 0.0025 0.004 0.0117
Chlamydia trachomatis pyruvate kinase 0.0027 0.0048 0.0264
Echinococcus multilocularis aldo keto reductase 0.0025 0.004 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0071 0.0197 0.0197
Loa Loa (eye worm) calpain D 0.0021 0.0027 0.0121
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0054 0.0181
Toxoplasma gondii thymidylate kinase 0.0147 0.0453 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0068 0.0184 0.4005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0187 0.0588 0.8913
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0025 0.004 0.0039
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0029 0.0054 0.0685
Plasmodium vivax thymidylate kinase, putative 0.0147 0.0453 1
Leishmania major hypothetical protein, unknown function 0.0021 0.0027 0.0504
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.007 0.0193 0.4203
Trypanosoma brucei calpain-like protein, putative 0.007 0.0193 0.4203
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0076 0.0213 0.0212
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0025 0.004 0.0039
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0025 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0243
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0504
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0029 0.0054 0.0279
Onchocerca volvulus 0.0116 0.0347 0.1739
Trypanosoma brucei kinesin, putative 0.0049 0.0122 0.2613
Schistosoma mansoni notch 0.0045 0.0106 0.0106
Schistosoma mansoni rab6-interacting 0.0018 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0666 0.2206 1
Loa Loa (eye worm) animal heme peroxidase 0.0279 0.0898 0.407
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Echinococcus granulosus histone lysine methyltransferase setb 0.0076 0.0213 0.0212
Echinococcus granulosus calpain A 0.0195 0.0613 0.0613
Echinococcus multilocularis neurogenic locus protein delta 0.0045 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0243
Trypanosoma cruzi kinesin, putative 0.0049 0.0122 0.2613
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0061 0.1257
Brugia malayi Calcium binding EGF domain containing protein 0.0045 0.0106 0.0481
Leishmania major cytochrome p450-like protein 0.0031 0.0061 0.1257
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.003 0.0057 0.0259
Brugia malayi Pyruvate kinase, muscle isozyme 0.0027 0.0048 0.0214
Brugia malayi beta-lactamase family protein 0.0029 0.0054 0.0243
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0014 0.0216
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0028 0.0052 0.0233
Loa Loa (eye worm) hypothetical protein 0.003 0.0057 0.0259
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0054 0.0181
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0052 0.1055
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0195 0.0613 0.0613
Schistosoma mansoni hypothetical protein 0.0045 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Brugia malayi Calcium binding EGF domain containing protein 0.0045 0.0106 0.0481
Echinococcus granulosus pyruvate kinase 0.0014 0.0003 0.0003
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0025 0.004 0.0039
Brugia malayi RNA binding protein 0.0052 0.013 0.0587
Loa Loa (eye worm) pyruvate kinase-PB 0.0019 0.002 0.0088
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Echinococcus granulosus calpain 7 C02 family 0.007 0.0193 0.0193
Brugia malayi jmjC domain containing protein 0.0054 0.0138 0.0626
Echinococcus granulosus calpain A 0.007 0.0193 0.0193
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0313 0.1013 0.1012
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0065 0.0175 0.0791
Trichomonas vaginalis set domain proteins, putative 0.0604 0.1995 0.9038
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0068 0.0184 0.0184
Echinococcus multilocularis 0.0016 0.0009 0.0009
Brugia malayi hypothetical protein 0.0279 0.0898 0.407
Giardia lamblia Hypothetical protein 0.0666 0.2206 1
Schistosoma mansoni thymidine kinase 0.2974 1 1
Schistosoma mansoni calpain-7 (C02 family) 0.0076 0.0211 0.0211
Schistosoma mansoni intermediate filament proteins 0.0065 0.0175 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0027 0.0504
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0025 0.004 0.0039
Loa Loa (eye worm) thioredoxin reductase 0.0082 0.0233 0.1054
Onchocerca volvulus Dual oxidase homolog 0.0279 0.0898 0.45
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0037 0.0103
Brugia malayi Animal haem peroxidase family protein 0.0279 0.0898 0.407
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0021 0.0027 0.0059
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0025 0.004 0.0039
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0026 0.0117
Loa Loa (eye worm) thymidylate kinase 0.0147 0.0453 0.2052
Mycobacterium tuberculosis Probable reductase 0.0187 0.0588 0.8913
Leishmania major calpain protease-like protein 0.0021 0.0027 0.0504
Leishmania major prostaglandin f synthase, putative 0.0025 0.004 0.079
Schistosoma mansoni thymidylate kinase 0.0147 0.0453 0.0452
Brugia malayi jmjC domain containing protein 0.0014 0.0004 0.0018
Mycobacterium tuberculosis Probable lipase LipE 0.0029 0.0054 0.0685
Onchocerca volvulus 0.0018 0.0017 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0052 0.013 0.0129
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0052 0.1055
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0039 0.0088 0.1945
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0027 0.0504
Schistosoma mansoni thymidylate kinase 0.0147 0.0453 0.0452
Trypanosoma cruzi pyruvate kinase 2, putative 0.0027 0.0048 0.0964
Toxoplasma gondii phosphofructokinase PFKII 0.0024 0.0037 0.0809
Echinococcus granulosus beta LACTamase domain containing family member 0.0029 0.0054 0.0054
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0024 0.0037 0.0153
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0037
Loa Loa (eye worm) hypothetical protein 0.0279 0.0898 0.407
Mycobacterium ulcerans 6-phosphofructokinase 0.0089 0.0255 0.1543
Trypanosoma brucei hypothetical protein 0.0021 0.0027 0.0504
Brugia malayi Blistered cuticle protein 3 0.0279 0.0898 0.407
Echinococcus multilocularis lamin 0.0065 0.0175 0.0174
Trichomonas vaginalis esterase, putative 0.0029 0.0054 0.0181
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0014 0.0216
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0024 0.0037 0.0513
Echinococcus granulosus JmjC domain containing protein 4 0.0014 0.0004 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0037 0.0103
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0025 0.004 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.0213 0.0212
Toxoplasma gondii thioredoxin reductase 0.0082 0.0233 0.5142
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0022 0.0036
Schistosoma mansoni septate junction protein 0.0045 0.0106 0.0106
Echinococcus granulosus pyruvate kinase 0.0014 0.0003 0.0003
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0028 0.0052 0.0051
Mycobacterium tuberculosis Probable oxidoreductase 0.0208 0.0658 1
Plasmodium falciparum thioredoxin reductase 0.0028 0.0052 0.1086
Echinococcus multilocularis hypothetical protein 0.007 0.0193 0.0193
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0028 0.0052 0.1133
Schistosoma mansoni lipoxygenase 0.0051 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0481
Trichomonas vaginalis aldo-keto reductase, putative 0.0025 0.004 0.0117
Echinococcus granulosus Solute carrier family 22 5 0.0952 0.317 0.3169
Trypanosoma brucei Calpain-like protein 1.1 0.0021 0.0027 0.0504
Onchocerca volvulus 0.0025 0.004 0.0198
Echinococcus multilocularis aldo keto reductase 0.0025 0.004 0.0039
Brugia malayi phosphofructokinase 0.0089 0.0255 0.1156
Echinococcus granulosus intermediate filament protein 0.0065 0.0175 0.0174
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0028 0.0052 0.1133

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 18 % Inhibition of human recombinant PDE7A1 assessed as inhibition of hydrolysis of [3H]cAMP at 10 uM after 20 mins by scintillation proximity assay ChEMBL. 25264825

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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