Detailed information for compound 975771

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 252.184 | Formula: C9H8N4O5
  • H donors: 3 H acceptors: 4 LogP: -1.54 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ncn(c(=O)n1)C/C=C/1\OC(=O)C(=C1O)O
  • InChi: 1S/C9H8N4O5/c10-8-11-3-13(9(17)12-8)2-1-4-5(14)6(15)7(16)18-4/h1,3,14-15H,2H2,(H2,10,12,17)/b4-1-
  • InChiKey: MTGUFNNLEWBDGC-RJRFIUFISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.001 0.0001 0.0001
Schistosoma mansoni alpha-glucosidase 0.0137 0.0258 0.0258
Echinococcus granulosus contactin 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.1654 0.3319 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0052 0.0135
Echinococcus granulosus Down syndrome cell adhesion molecule 0.001 0.0001 0.0001
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.001 0.0001 0.0001
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0263 0.0512 0.5068
Trypanosoma brucei endonuclease G, putative 0.0263 0.0512 0.5068
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0221 0.0427 0.0427
Echinococcus granulosus EG95 0.001 0.0001 0.0001
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0221 0.0427 0.0427
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0232 0.0448 0.0448
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0221 0.0427 0.1269
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0221 0.0427 0.0427
Echinococcus granulosus cpg binding protein 0.0029 0.004 0.004
Schistosoma mansoni titin 0.001 0.0001 0.0001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Onchocerca volvulus 0.0221 0.0427 0.1287
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0052 0.0052
Leishmania major DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0221 0.0427 0.0427
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.051 0.1009 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0004 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0001
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0069 0.0119 0.1176
Echinococcus granulosus titin 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0069 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.001 0.0001 0.0001
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0221 0.0427 0.0427
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0221 0.0427 0.0427
Schistosoma mansoni hypothetical protein 0.001 0.0001 0.0001
Brugia malayi CXXC zinc finger family protein 0.0028 0.0036 0.0036
Leishmania major ethanolamine phosphotransferase, putative 0.0069 0.0119 0.1176
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Echinococcus multilocularis geminin 0.0343 0.0672 0.0672
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0069 0.0119 0.0119
Echinococcus multilocularis fibronectin type III domain-containing protein 0.001 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0052 0.0505
Echinococcus granulosus anosmin 1 0.001 0.0001 0.0001
Onchocerca volvulus 0.0221 0.0427 0.1287
Echinococcus granulosus roundabout 2 0.001 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0551 0.1643
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0056 0.0548
Echinococcus multilocularis 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0056 0.0158
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.001 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.007 0.007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0551 0.1643
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0022 0.0022
Loa Loa (eye worm) lethal protein 805 0.001 0.0001 0.0001
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0221 0.0427 0.0427
Schistosoma mansoni hypothetical protein 0.0947 0.1891 0.1891
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0001
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0052 0.0052
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0439 0.0866 0.0866
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0232 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1654 0.3319 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.001 0.0001 0.0001
Loa Loa (eye worm) myotactin form A 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Onchocerca volvulus 0.0169 0.0322 0.0969
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0551 0.1643
Onchocerca volvulus 4.1 G protein, putative homolog 0.0221 0.0427 0.1287
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0232 0.0448 0.0448
Onchocerca volvulus 0.0021 0.0022 0.0066
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0069 0.0119 0.0119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0343 0.0672 0.0672
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1654 0.3319 1
Brugia malayi Fibronectin type III domain containing protein 0.001 0.0001 0.0001
Echinococcus multilocularis neuropeptide s receptor 0.0482 0.0954 0.0954
Brugia malayi hypothetical protein 0.0021 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0022
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0221 0.0427 0.0427
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0069 0.0119 0.0119
Schistosoma mansoni alpha glucosidase 0.0035 0.0052 0.0052
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Echinococcus granulosus roundabout 2 0.001 0.0001 0.0001
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0439 0.0866 0.0866
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Echinococcus multilocularis hypothetical protein 0.0221 0.0427 0.0427
Echinococcus multilocularis dna polymerase eta 0.0063 0.0106 0.0106
Schistosoma mansoni ephrin receptor 0.001 0.0001 0.0001
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.0551 0.5
Onchocerca volvulus 0.0221 0.0427 0.1287
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Loa Loa (eye worm) projectin 0.001 0.0001 0.0001
Schistosoma mansoni cell adhesion molecule 0.001 0.0001 0.0001
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0232 0.0448 0.0448
Echinococcus multilocularis transferase 0.0069 0.0119 0.0119
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0439 0.0866 0.0866
Onchocerca volvulus 0.001 0.0001 0.0003
Giardia lamblia DINP protein human, muc B family 0.0038 0.0056 0.0158
Trypanosoma brucei protein tyrosine phosphatase 1 0.0221 0.0427 0.4226
Brugia malayi Lethal protein 805 0.001 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.007 0.007
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0056 0.0158
Schistosoma mansoni protein tyrosine phosphatase 0.0221 0.0427 0.0427
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0069 0.0119 0.0119
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0052 0.0135
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0056 0.0056
Loa Loa (eye worm) protein tyrosine phosphatase 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0069 0.0119 0.034
Leishmania major endonuclease G, putative 0.0263 0.0512 0.5068
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0232 0.0448 0.0448
Schistosoma mansoni cpg binding protein 0.0028 0.0036 0.0036
Leishmania major DNA polymerase kappa, putative 0.0012 0.0004 0.0029
Loa Loa (eye worm) hypothetical protein 0.0159 0.0301 0.0301
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0221 0.0427 0.4226
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0159 0.0301 0.0301
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0259 0.0909
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.051 0.1009 0.3027
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0302 0.0302
Schistosoma mansoni hemicentin 0.001 0.0001 0.0001
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.0302 0.0302
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0221 0.0427 0.0427
Echinococcus multilocularis usherin 0.001 0.0001 0.0001
Schistosoma mansoni neuroglian 0.001 0.0001 0.0001
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0232 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0069 0.0119 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0439 0.0866 0.0866
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0069 0.0119 0.0349
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.1144 0.229 1
Mycobacterium ulcerans hypothetical protein 0.0069 0.0119 0.0349
Echinococcus granulosus dna polymerase kappa 0.0038 0.0056 0.0056
Onchocerca volvulus 0.0439 0.0866 0.2608
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0069 0.0119 0.036
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0001
Echinococcus multilocularis cell adhesion molecule 0.001 0.0001 0.0001
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0221 0.0427 0.4226
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Schistosoma mansoni factor for adipocyte differentiation 0.001 0.0001 0.0001
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0004 0.0029
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0056 0.0149
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0221 0.0427 0.0427
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0001
Onchocerca volvulus 0.0092 0.0167 0.0502
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0036 0.0036
Echinococcus multilocularis Netrin receptor DCC 0.001 0.0001 0.0001
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.0106 0.1047
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Brugia malayi myotactin form A 0.001 0.0001 0.0001
Loa Loa (eye worm) UNCoordinated family member 0.001 0.0001 0.0001
Loa Loa (eye worm) CAMK protein kinase 0.001 0.0001 0.0001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0069 0.0119 0.0119
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0022 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0001
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0259 0.077
Schistosoma mansoni lipoxygenase 0.0123 0.0229 0.0229
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0052 0.0135
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.0551 0.1651
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0001
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0221 0.0427 0.0427
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0052 0.0135
Onchocerca volvulus 0.0221 0.0427 0.1287
Brugia malayi Fibronectin type III domain containing protein 0.001 0.0001 0.0001
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0947 0.1891 0.1891
Trypanosoma cruzi hypothetical protein, conserved 0.051 0.1009 1
Trypanosoma brucei glucosidase, putative 0.0035 0.0052 0.0505
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Onchocerca volvulus 0.0221 0.0427 0.1287
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0232 0.0448 0.0448
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0069 0.0119 0.0119
Echinococcus multilocularis contactin neuroglian septate junction protein 0.001 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0033 0.0315
Brugia malayi hypothetical protein 0.001 0.0001 0.0001
Echinococcus granulosus transferase 0.0069 0.0119 0.0119
Brugia malayi hypothetical protein 0.0221 0.0427 0.0427
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Onchocerca volvulus 0.0947 0.1891 0.5698
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0221 0.0427 0.0427
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0551 0.1643
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0052 0.0135
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0221 0.0427 0.0427
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0232 0.0448 0.0448
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0069 0.0119 0.036
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0007 0.0007
Echinococcus multilocularis roundabout 2 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0022
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Trypanosoma brucei endonuclease G, putative 0.0263 0.0512 0.5068
Echinococcus multilocularis titin 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0056 0.0548
Echinococcus granulosus G1Y162 protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0004 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0004 0.0029
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0056 0.0149
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0069 0.0119 0.0119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.007 0.007
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0221 0.0427 0.0427
Leishmania major hypothetical protein, conserved 0.051 0.1009 1
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0056 0.0056
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0007 0.006
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0069 0.0119 0.0119
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.4963 1 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0439 0.0866 0.0866
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.001 0.0001 0.0001
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0056 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0004 0.0029
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0221 0.0427 0.1269
Trypanosoma cruzi endonuclease G, putative 0.0263 0.0512 0.5068
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0022 0.0022
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.037 0.0726 0.0726
Brugia malayi Protein-tyrosine phosphatase 0.039 0.0768 0.0768
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.01 0.01
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0052 0.0135
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.007 0.007
Echinococcus granulosus nephrin 0.001 0.0001 0.0001
Echinococcus multilocularis Fibronectin, type III 0.001 0.0001 0.0001
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.037 0.0726 0.0726
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0439 0.0866 0.0866
Echinococcus granulosus neuroglian 0.001 0.0001 0.0001
Onchocerca volvulus 0.001 0.0001 0.0003
Onchocerca volvulus 0.0221 0.0427 0.1287
Echinococcus multilocularis ectonucleotide 0.037 0.0726 0.0726
Schistosoma mansoni hypothetical protein 0.0069 0.0119 0.0119
Brugia malayi hypothetical protein 0.0221 0.0427 0.0427
Brugia malayi hypothetical protein 0.0221 0.0427 0.0427
Brugia malayi Fibronectin type III domain containing protein 0.001 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Onchocerca volvulus 0.0221 0.0427 0.1287
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1654 0.3319 1
Brugia malayi Thrombospondin type 1 domain containing protein 0.0947 0.1891 0.1891
Onchocerca volvulus 0.1654 0.3319 1
Schistosoma mansoni cpg binding protein 0.0029 0.004 0.004
Echinococcus granulosus anosmin 1 0.001 0.0001 0.0001
Schistosoma mansoni cell adhesion molecule 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Trypanosoma brucei unspecified product 0.0026 0.0033 0.0315
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.051 0.1009 0.3027
Schistosoma mansoni titin 0.001 0.0001 0.0001
Leishmania major tyrosine specific protein phosphatase, putative 0.0221 0.0427 0.4226
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.001 0.0001 0.0001
Schistosoma mansoni polycystin 1-related 0.0021 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.051 0.1009 1
Onchocerca volvulus 0.0221 0.0427 0.1287
Echinococcus multilocularis Endonuclease G 0.0263 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Brugia malayi Fibronectin type III domain containing protein 0.001 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Schistosoma mansoni factor for adipocyte differentiation 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0069 0.0119 0.0119
Schistosoma mansoni cpg binding protein 0.0029 0.004 0.004
Brugia malayi Protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Onchocerca volvulus 0.0028 0.0036 0.011
Onchocerca volvulus 0.0221 0.0427 0.1287
Brugia malayi myotactin form B 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0221 0.0427 0.0427
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1654 0.3319 1
Onchocerca volvulus 0.0221 0.0427 0.1287
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0551 0.1643
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0221 0.0427 0.4226
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.001 0.0001 0.0001
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0263 0.0512 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0069 0.0119 0.0119
Schistosoma mansoni lipoxygenase 0.0086 0.0154 0.0154
Onchocerca volvulus 0.0221 0.0427 0.1287
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0004 0.0029
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0232 0.0448 0.0448
Onchocerca volvulus 0.001 0.0001 0.0003
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0007 0.006
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.0229 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0033 0.0315
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0221 0.0427 0.0427
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.4963 1 1
Echinococcus granulosus Endonuclease G 0.0263 0.0512 0.0512
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1654 0.3319 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0232 0.0448 0.0448
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.1654 0.3319 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0052 0.0135
Echinococcus granulosus titin 0.001 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0001 0.0001
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0221 0.0427 0.0427
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0052 0.0943
Onchocerca volvulus 0.001 0.0001 0.0003
Onchocerca volvulus 0.001 0.0001 0.0003
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0221 0.0427 0.0427
Schistosoma mansoni hypothetical protein 0.0069 0.0119 0.0119
Brugia malayi Lethal protein 805 0.001 0.0001 0.0001
Trypanosoma cruzi endonuclease G, putative 0.0263 0.0512 0.5068
Schistosoma mansoni protein tyrosine phosphatase 0.0221 0.0427 0.0427
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0846 0.1688 0.1688
Onchocerca volvulus 0.001 0.0001 0.0003
Onchocerca volvulus 0.0221 0.0427 0.1287
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.037 0.0726 0.0726
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0221 0.0427 0.0427
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0221 0.0427 0.0427
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0001
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0259 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0232 0.0448 0.0448
Onchocerca volvulus 0.001 0.0001 0.0003
Schistosoma mansoni protein tyrosine phosphatase 0.0232 0.0448 0.0448
Brugia malayi hypothetical protein 0.0221 0.0427 0.0427
Schistosoma mansoni loxhd1 0.0021 0.0022 0.0022
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0221 0.0427 0.0427
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0052 0.0052
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0069 0.0119 0.0119
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.038 0.0748 0.0748
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0232 0.0448 0.0448
Echinococcus granulosus Netrin receptor DCC 0.001 0.0001 0.0001
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0004 0.0029
Trypanosoma brucei unspecified product 0.0026 0.0033 0.0315
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.01 0.0198
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0221 0.0427 0.0427
Brugia malayi hypothetical protein 0.0221 0.0427 0.0427
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0001
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.4963 1 1
Onchocerca volvulus 0.0221 0.0427 0.1287
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Brugia malayi hypothetical protein 0.0069 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0069 0.0119 0.036
Schistosoma mansoni nephrin 0.001 0.0001 0.0001
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0022 0.0022
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0551 0.1643
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0439 0.0866 0.0866
Echinococcus granulosus RUN 0.0021 0.0022 0.0022
Echinococcus multilocularis neuropeptide receptor A26 0.0482 0.0954 0.0954
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Schistosoma mansoni DNA polymerase eta 0.0063 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0106 0.0106
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.001 0.0001 0.0001
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1654 0.3319 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0221 0.0427 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0056 0.0548
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0232 0.0448 0.0448
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.01 0.1899
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0007 0.006
Brugia malayi hypothetical protein 0.0069 0.0119 0.0119
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.01 0.0291
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Onchocerca volvulus 0.0221 0.0427 0.1287
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.1654 0.3319 0.3319
Loa Loa (eye worm) protein-tyrosine phosphatase 0.4963 1 1
Echinococcus multilocularis Fibronectin type III domain containing protein 0.001 0.0001 0.0001
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.01 0.01
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0054 0.0529
Schistosoma mansoni tripartite motif protein trim9 0.001 0.0001 0.0001
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0221 0.0427 0.0427
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0221 0.0427 0.0427
Onchocerca volvulus 0.0439 0.0866 0.2608
Loa Loa (eye worm) hypothetical protein 0.0439 0.0866 0.0866
Schistosoma mansoni myosin-binding protein-related 0.001 0.0001 0.0001
Echinococcus multilocularis anosmin 1 0.001 0.0001 0.0001
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0221 0.0427 0.0427
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1654 0.3319 1
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0263 0.0512 0.5068
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0001
Echinococcus granulosus protein tyrosine phosphatase n9 0.0221 0.0427 0.0427
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0004 0.0029
Echinococcus granulosus fibronectin type III domain-containing protein 0.001 0.0001 0.0001
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0439 0.0866 0.0866
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.007 0.007
Brugia malayi SPRY domain containing protein 0.001 0.0001 0.0001
Onchocerca volvulus 0.001 0.0001 0.0003
Schistosoma mansoni cell adhesion molecule 0.001 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0021 0.0022 0.0022
Onchocerca volvulus 0.001 0.0001 0.0003
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0001
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0439 0.0866 0.0866
Brugia malayi Protein-tyrosine phosphatase 1 0.0221 0.0427 0.0427
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.001 0.0001 0.0001
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.001 0.0001 0.0001
Echinococcus granulosus insulin growth factor 1 receptor beta 0.001 0.0001 0.0001
Brugia malayi hypothetical protein 0.0021 0.0022 0.0022
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0232 0.0448 0.0448
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0439 0.0866 0.0866
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0007 0.006
Brugia malayi AEL166Cp 0.0069 0.0119 0.0119
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0069 0.0119 0.036
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0439 0.0866 0.0866
Echinococcus granulosus dna polymerase eta 0.0063 0.0106 0.0106
Schistosoma mansoni cell adhesion molecule 0.001 0.0001 0.0001
Trichomonas vaginalis pten, drome, putative 0.0221 0.0427 0.1269
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0221 0.0427 0.0427
Brugia malayi hypothetical protein 0.001 0.0001 0.0001
Echinococcus multilocularis titin 0.001 0.0001 0.0001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0052 0.0135
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.001 0.0001 0.0001
Echinococcus granulosus Fibronectin type III domain containing protein 0.001 0.0001 0.0001
Echinococcus granulosus cell adhesion molecule 0.001 0.0001 0.0001
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0007 0.0021
Onchocerca volvulus 0.001 0.0001 0.0003
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0232 0.0448 0.0448
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0069 0.0119 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.0427 0.0427
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0004 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.007 0.007
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0221 0.0427 0.0427
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0004 0.0029
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0069 0.0119 0.034
Onchocerca volvulus 0.0221 0.0427 0.1287
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0232 0.0448 0.0448
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0087 0.1628
Loa Loa (eye worm) hypothetical protein 0.0063 0.0106 0.0106
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0221 0.0427 0.0427
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.001 0.0001 0.0001
Onchocerca volvulus 0.001 0.0001 0.0003
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.01 0.01
Onchocerca volvulus 0.0221 0.0427 0.1287
Schistosoma mansoni alpha-glucosidase 0.0137 0.0258 0.0258
Brugia malayi Doublecortin family protein 0.0021 0.0022 0.0022
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0221 0.0427 0.0427
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.01 0.0291
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.007 0.007
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0439 0.0866 0.0866
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Brugia malayi protein unc-22 0.001 0.0001 0.0001
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.001 0.0001 0.0001
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.001 0.0001 0.0001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Onchocerca volvulus 0.0221 0.0427 0.1287
Schistosoma mansoni titin 0.001 0.0001 0.0001
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.1654 0.3319 0.3319
Echinococcus granulosus Netrin receptor DCC 0.001 0.0001 0.0001
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0221 0.0427 0.0427
Echinococcus granulosus usherin 0.001 0.0001 0.0001
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0022 0.1554
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0551 0.1643
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Schistosoma mansoni rab6-interacting 0.0021 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0052 0.0505
Onchocerca volvulus 0.001 0.0001 0.0003
Trypanosoma brucei endonuclease G, putative 0.0263 0.0512 0.5068
Echinococcus multilocularis anosmin 1 0.001 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0033 0.0315
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0439 0.0866 0.0866
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0221 0.0427 0.0427
Leishmania major DNA polymerase eta, putative 0.0037 0.0054 0.0529
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0052 0.0135
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.01 0.0291
Brugia malayi Fibronectin type III domain containing protein 0.001 0.0001 0.0001
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0221 0.0427 0.0427
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.001 0.0001 0.0001
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0439 0.0866 0.0866
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Echinococcus multilocularis neuroglian 0.001 0.0001 0.0001
Schistosoma mansoni pcd6 interacting protein-related 0.0221 0.0427 0.0427
Echinococcus multilocularis cpg binding protein 0.0029 0.004 0.004
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0439 0.0866 0.0866
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0022 0.0022
Onchocerca volvulus 0.0221 0.0427 0.1287
Leishmania major DNA polymerase eta, putative 0.0063 0.0106 0.1047
Schistosoma mansoni endonuclease related 0.0263 0.0512 0.0512
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.0229 0.0229
Onchocerca volvulus 0.0221 0.0427 0.1287
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0221 0.0427 0.4226
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0069 0.0119 0.036
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0221 0.0427 0.0427
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0263 0.0512 0.5068
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Schistosoma mansoni hypothetical protein 0.0069 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Onchocerca volvulus 0.001 0.0001 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0001
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0056 0.0149
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0052 0.0505
Echinococcus granulosus anosmin 1 0.001 0.0001 0.0001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0439 0.0866 0.0866
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0221 0.0427 0.1269
Onchocerca volvulus 0.0221 0.0427 0.1287
Onchocerca volvulus 0.0021 0.0022 0.0066
Onchocerca volvulus 0.0221 0.0427 0.1287
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.001 0.0001 0.0001
Echinococcus granulosus neuropeptide receptor A26 0.0482 0.0954 0.0954
Echinococcus multilocularis anosmin 1 0.001 0.0001 0.0001
Giardia lamblia Protein tyrosine phosphatase 0.0221 0.0427 0.1277
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0099 0.0099
Echinococcus multilocularis transfer RNA-Phe 0.001 0.0001 0.0001
Echinococcus granulosus Fibronectin type III 0.001 0.0001 0.0001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0056 0.0056
Schistosoma mansoni cell adhesion molecule 0.001 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.001 0.0001 0.0001
Schistosoma mansoni nephrin 0.001 0.0001 0.0001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0007
Brugia malayi polk-prov protein 0.0012 0.0004 0.0004
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0056 0.0548
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0056 0.0548
Schistosoma mansoni rab6-interacting 0.0021 0.0022 0.0022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.01 0.0986
Echinococcus multilocularis roundabout 2 0.001 0.0001 0.0001
Echinococcus multilocularis RUN 0.0021 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Echinococcus granulosus ectonucleotide 0.037 0.0726 0.0726
Schistosoma mansoni hypothetical protein 0.0343 0.0672 0.0672
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0551 0.1643
Onchocerca volvulus 0.0221 0.0427 0.1287
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0551 0.1643
Trypanosoma brucei unspecified product 0.0038 0.0056 0.0548
Schistosoma mansoni factor for adipocyte differentiation 0.001 0.0001 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0052 0.0135
Echinococcus multilocularis Netrin receptor DCC 0.001 0.0001 0.0001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Brugia malayi Fibronectin type III domain containing protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0221 0.0427 0.0427
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0069 0.0119 0.0119
Echinococcus granulosus neuropeptide s receptor 0.0482 0.0954 0.0954
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.0106 0.1047
Brugia malayi endonuclease G, mitochondrial precursor 0.0263 0.0512 0.0512
Schistosoma mansoni hypothetical protein 0.0069 0.0119 0.0119
Echinococcus granulosus geminin 0.0343 0.0672 0.0672
Echinococcus granulosus roundabout 2 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0439 0.0866 0.0866
Loa Loa (eye worm) hypothetical protein 0.0439 0.0866 0.0866
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0056 0.0056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0221 0.0427 0.0427
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1654 0.3319 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0221 0.0427 0.0427
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0004 0.0029
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0022 0.0022
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.0427 0.0427
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0054 0.0991
Echinococcus multilocularis roundabout 2 0.001 0.0001 0.0001
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0159 0.0301 0.0301
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0551 0.1643
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0056 0.0056
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0022 0.0022
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0052 0.0135
Onchocerca volvulus 0.0221 0.0427 0.1287
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.0302 0.0302
Leishmania major DNA damage repair protein, putative 0.0012 0.0004 0.0029

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 8.92 uM Cytostatic activity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay ChEMBL. 21524828
IC50 (functional) = 23.5 uM Cytostatic activity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay ChEMBL. 21524828
IC50 (ADMET) = 54.27 uM Cytotoxicity against human WI38 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay ChEMBL. 21524828
IC50 (functional) > 100 uM Cytostatic activity against human MIAPaCa2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay ChEMBL. 21524828
IC50 (functional) > 100 uM Cytostatic activity against human SW620 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay ChEMBL. 21524828
IC50 (functional) > 100 uM Cytostatic activity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay ChEMBL. 21524828

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 21524828

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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