TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 467.39 | Formula: C25H24Cl2N4O
H donors: 1 H acceptors: 2 LogP: 5.39 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC1=C(C(=O)N2CCC(CC2)c2ccccc2)C(n2c(N1)ccn2)c1ccc(c(c1)Cl)Cl
InChi: 1S/C25H24Cl2N4O/c1-16-23(25(32)30-13-10-18(11-14-30)17-5-3-2-4-6-17)24(31-22(29-16)9-12-28-31)19-7-8-20(26)21(27)15-19/h2-9,12,15,18,24,29H,10-11,13-14H2,1H3
InChiKey: VXJCSLJGHFPZQS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, shaker-related subfamily, member 5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_127659	All targets in OG5_127659
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma japonicum	ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus granulosus	potassium voltage gated channel subfamily A	Get druggable targets OG5_127659	All targets in OG5_127659
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma japonicum	Potassium voltage-gated channel protein Shaker, putative	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus multilocularis	potassium voltage gated channel protein	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus multilocularis	potassium voltage gated channel subfamily A	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma japonicum	Potassium voltage-gated channel subfamily A member 5, putative	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus granulosus	potassium voltage gated channel protein	Get druggable targets OG5_127659	All targets in OG5_127659

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	voltage gated potassium channel	potassium voltage-gated channel, shaker-related subfamily, member 5	613 aa	521 aa	34.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0113	0.0492
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0855	0.1557	0.1548
Schistosoma mansoni	hypothetical protein	0.0078	0.0073	0.0055
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.01	0.0113	0.4278
Loa Loa (eye worm)	TK/DDR protein kinase	0.006	0.0038	0.0038
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0078	0.0073	0.1971
Entamoeba histolytica	histone deacetylase, putative	0.0152	0.0213	0.115
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.006	0.0038	0.0033
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0078	0.0073	0.0073
Echinococcus granulosus	histone deacetylase 3	0.0152	0.0213	0.0242
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Brugia malayi	Variant SH3 domain containing protein	0.0078	0.0073	0.0062
Brugia malayi	Sema domain containing protein	0.0405	0.0697	0.0687
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.006	0.0038	0.0038
Echinococcus granulosus	tyrosine kinase	0.006	0.0038	0.0033
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0102	0.0118	0.0128
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0066	0.0048	0.0045
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.01	0.0113	0.4278
Echinococcus granulosus	integrin linked protein kinase	0.006	0.0038	0.0033
Trypanosoma brucei	rac serine-threonine kinase, putative	0.01	0.0113	0.4278
Schistosoma mansoni	ephrin receptor	0.006	0.0038	0.002
Trypanosoma cruzi	PH domain containing protein, putative	0.0078	0.0073	0.1971
Schistosoma mansoni	hypothetical protein	0.0405	0.0697	0.068
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.006	0.0038	0.0033
Trypanosoma cruzi	histone deacetylase, putative	0.0152	0.0213	1
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0078	0.0073	0.0074
Echinococcus multilocularis	regulator of G protein signaling	0.0855	0.1557	0.185
Brugia malayi	Plexin repeat family protein	0.0956	0.1748	0.1739
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0078	0.0073	0.0074
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.01	0.0113	0.4278
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.006	0.0038	0.0033
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0855	0.1557	0.185
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.01	0.0113	0.0492
Echinococcus multilocularis	histone deacetylase 1	0.0152	0.0213	0.0242
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0177	0.0262	0.1472
Schistosoma mansoni	protein kinase	0.006	0.0038	0.002
Loa Loa (eye worm)	TK protein kinase	0.006	0.0038	0.0038
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Leishmania major	serine/threonine-protein kinase a, putative	0.01	0.0113	0.4278
Loa Loa (eye worm)	TK/EPH protein kinase	0.006	0.0038	0.0038
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4421	0.8366	0.8366
Echinococcus granulosus	GRB2 associated binding protein 3	0.0078	0.0073	0.0074
Echinococcus granulosus	Pleckstrin y	0.0078	0.0073	0.0074
Brugia malayi	Dynamin	0.0078	0.0073	0.0062
Echinococcus multilocularis	rac serine:threonine kinase	0.01	0.0113	0.0123
Entamoeba histolytica	hypothetical protein	0.0177	0.0262	0.1472
Schistosoma mansoni	z-protein (S1r protein)	0.0855	0.1557	0.1542
Trypanosoma brucei	histone deacetylase 4	0.0152	0.0213	1
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Echinococcus multilocularis	raf serine:threonine protein kinase	0.006	0.0038	0.0033
Brugia malayi	Histone deacetylase 1	0.0152	0.0213	0.0203
Schistosoma mansoni	hypothetical protein	0.0177	0.0262	0.0244
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Echinococcus granulosus	raf serine:threonine protein kinase	0.006	0.0038	0.0033
Echinococcus granulosus	plexin a4	0.1133	0.2087	0.2485
Echinococcus multilocularis	Pleckstrin y	0.0078	0.0073	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus granulosus	tyrosine protein kinase shark	0.006	0.0038	0.0033
Entamoeba histolytica	hypothetical protein	0.01	0.0113	0.0492
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Echinococcus granulosus	tyrosine protein kinase pr2	0.006	0.0038	0.0033
Loa Loa (eye worm)	TK protein kinase	0.006	0.0038	0.0038
Echinococcus granulosus	Regulator of G protein signaling 20	0.0855	0.1557	0.185
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Loa Loa (eye worm)	hypothetical protein	0.0855	0.1557	0.1557
Brugia malayi	Tyrosine-protein kinase PR2	0.006	0.0038	0.0028
Echinococcus granulosus	tyrosine protein kinase csk	0.006	0.0038	0.0033
Schistosoma mansoni	axis inhibition protein axin	0.0855	0.1557	0.1542
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.006	0.0038	0.0033
Brugia malayi	hypothetical protein	0.0405	0.0697	0.0687
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Schistosoma mansoni	protein kinase	0.0082	0.0079	0.0061
Echinococcus multilocularis	Pleckstrin y	0.0078	0.0073	0.0074
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0078	0.0073	0.0055
Leishmania major	hypothetical protein, conserved	0.0078	0.0073	0.1971
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0106	0.0126	0.0138
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0082	0.0079	0.0081
Loa Loa (eye worm)	AUR protein kinase	0.0083	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Brugia malayi	hypothetical protein	0.006	0.0038	0.0028
Echinococcus multilocularis	tyrosine protein kinase csk	0.006	0.0038	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0177	0.0262	0.1472
Schistosoma mansoni	vesicular amine transporter	0.0126	0.0163	0.0145
Loa Loa (eye worm)	histone deacetylase 3	0.0152	0.0213	0.0213
Echinococcus multilocularis	axis inhibition protein axin	0.0855	0.1557	0.185
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.006	0.0038	0.0033
Entamoeba histolytica	PH domain containing protein	0.0078	0.0073	0.0227
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Brugia malayi	probable spectrin beta chain	0.0078	0.0073	0.0062
Schistosoma mansoni	tyrosine protein kinase	0.006	0.0038	0.002
Loa Loa (eye worm)	TK/INSR protein kinase	0.006	0.0038	0.0038
Brugia malayi	SH2 domain containing protein	0.006	0.0038	0.0028
Toxoplasma gondii	histone deacetylase HDAC4	0.0152	0.0213	1
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Echinococcus multilocularis	histone deacetylase	0.0152	0.0213	0.0242
Loa Loa (eye worm)	TK protein kinase	0.006	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Loa Loa (eye worm)	TK/CSK protein kinase	0.006	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0262	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Brugia malayi	protein-tyrosine kinase	0.006	0.0038	0.0028
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Loa Loa (eye worm)	TK/Met protein kinase	0.006	0.0038	0.0038
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0114	0.0141	0.0156
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.006	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0855	0.1557	1
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0078	0.0073	0.0227
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.006	0.0038	0.0033
Schistosoma mansoni	protein kinase	0.006	0.0038	0.002
Loa Loa (eye worm)	hypothetical protein	0.0855	0.1557	0.1557
Echinococcus multilocularis	transcription factor collier	0.0177	0.0262	0.0301
Echinococcus multilocularis	actin binding protein anillin	0.0078	0.0073	0.0074
Trichomonas vaginalis	histone deacetylase, putative	0.0152	0.0213	0.115
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Brugia malayi	integrin-linked kinase	0.006	0.0038	0.0028
Schistosoma mansoni	ephrin receptor	0.0066	0.0048	0.003
Echinococcus granulosus	c src tyrosine kinase	0.006	0.0038	0.0033
Trypanosoma cruzi	PH domain containing protein, putative	0.0078	0.0073	0.1971
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.006	0.0038	0.0028
Trypanosoma cruzi	histone deacetylase, putative	0.0152	0.0213	1
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Onchocerca volvulus		0.0078	0.0073	0.0201
Trypanosoma cruzi	histone deacetylase, putative	0.0152	0.0213	1
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus granulosus	oxysterol binding protein 1	0.0078	0.0073	0.0074
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.01	0.0113	0.4278
Loa Loa (eye worm)	protein kinase domain-containing protein	0.006	0.0038	0.0038
Brugia malayi	Probable exocyst complex component Sec5	0.0177	0.0262	0.0252
Schistosoma mansoni	axis inhibition protein axin	0.0855	0.1557	0.1542
Echinococcus granulosus	regulator of G protein signaling 7	0.0855	0.1557	0.185
Brugia malayi	PH domain containing protein	0.0078	0.0073	0.0062
Echinococcus granulosus	tyrosine protein kinase csk	0.006	0.0038	0.0033
Brugia malayi	PH domain containing protein	0.0078	0.0073	0.0062
Trypanosoma brucei	histone deacetylase, putative	0.0152	0.0213	1
Trypanosoma brucei	protein kinase, putative	0.0082	0.0079	0.2307
Entamoeba histolytica	protein kinase, putative	0.01	0.0113	0.0492
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.006	0.0038	0.0033
Entamoeba histolytica	protein kinase domain containing protein	0.0238	0.0377	0.2232
Loa Loa (eye worm)	hypothetical protein	0.0405	0.0697	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Trypanosoma cruzi	hypothetical protein	0.0078	0.0073	0.1971
Plasmodium falciparum	calcium-dependent protein kinase 7	0.01	0.0113	0.4278
Echinococcus multilocularis	natriuretic peptide receptor 1	0.006	0.0038	0.0033
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.006	0.0038	0.0033
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.4421	0.8366	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.006	0.0038	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.0083	0.0081	0.0283
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Trichomonas vaginalis	alpha chimerin, putative	0.0078	0.0073	0.0227
Echinococcus granulosus	potassium voltage gated channel protein	0.0106	0.0126	0.0138
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0078	0.0073	0.0073
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.006	0.0038	0.002
Trypanosoma cruzi	Protein kinase B	0.01	0.0113	0.4278
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0078	0.0073	0.1971
Echinococcus granulosus	kinase suppressor of Ras 1	0.006	0.0038	0.0033
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0078	0.0073	0.0227
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0078	0.0073	0.0227
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0152	0.0213	0.115
Echinococcus granulosus	tyrosine protein kinase ABL1	0.006	0.0038	0.0033
Loa Loa (eye worm)	TK protein kinase	0.006	0.0038	0.0038
Onchocerca volvulus		0.0405	0.0697	0.385
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0073	0.0227
Schistosoma mansoni	protein kinase	0.0082	0.0079	0.0061
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.006	0.0038	0.0033
Echinococcus granulosus	tyrosine protein kinase Src42A	0.006	0.0038	0.0033
Echinococcus granulosus	histone deacetylase 6	0.0152	0.0213	0.0242
Loa Loa (eye worm)	TK/EGFR protein kinase	0.006	0.0038	0.0038
Loa Loa (eye worm)	TK protein kinase	0.006	0.0038	0.0038
Schistosoma mansoni	histone deacetylase 1 2 3	0.0152	0.0213	0.0195
Entamoeba histolytica	protein kinase, putative	0.0083	0.0081	0.0283
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Loa Loa (eye worm)	RGC/RGC protein kinase	0.006	0.0038	0.0038
Brugia malayi	Plekhf2 protein	0.0078	0.0073	0.0062
Trichomonas vaginalis	AGC family protein kinase	0.0083	0.0081	0.0283
Loa Loa (eye worm)	syntrophin-1	0.0078	0.0073	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Schistosoma mansoni	goodpasture antigen-binding protein	0.0078	0.0073	0.0055
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0855	0.1557	0.1557
Brugia malayi	PH domain containing protein	0.0078	0.0073	0.0062
Leishmania major	protein kinase, putative	0.0082	0.0079	0.2307
Schistosoma mansoni	regulator of G protein signaling	0.0855	0.1557	0.1542
Echinococcus multilocularis	protein KINase family member (kin 25)	0.006	0.0038	0.0033
Echinococcus granulosus	tyrosine protein kinase Fyn	0.006	0.0038	0.0033
Schistosoma mansoni	protein tyrosine kinase	0.006	0.0038	0.002
Brugia malayi	PXA domain containing protein	0.0855	0.1557	0.1548
Trichomonas vaginalis	conserved hypothetical protein	0.0177	0.0262	0.1472
Echinococcus multilocularis	integrin linked protein kinase	0.006	0.0038	0.0033
Loa Loa (eye worm)	AUR protein kinase	0.0083	0.0081	0.0081
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.3189	0.6013	0.7184
Echinococcus multilocularis	histone deacetylase 7	0.0152	0.0213	0.0242
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.006	0.0038	0.0033
Brugia malayi	Syntrophin-1	0.0078	0.0073	0.0062
Echinococcus multilocularis	cytohesin 1	0.0078	0.0073	0.0074
Brugia malayi	PH domain containing protein	0.0078	0.0073	0.0062
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0073	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0078	0.0073	0.1971
Trypanosoma cruzi	histone deacetylase, putative	0.0152	0.0213	1
Echinococcus multilocularis	protein kinase	0.006	0.0038	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Echinococcus granulosus	tyrosine protein kinase Fyn	0.006	0.0038	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0177	0.0262	0.1472
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus granulosus	fibroblast growth factor receptor 4	0.006	0.0038	0.0033
Trypanosoma brucei	histone deacetylase 2	0.0152	0.0213	1
Brugia malayi	Protein kinase domain containing protein	0.01	0.0113	0.0103
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0046	0.0011	0.0011
Trichomonas vaginalis	hypothetical protein	0.0078	0.0073	0.0227
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.055	0.0974	0.0974
Brugia malayi	regulator of G-protein signaling egl-10	0.0855	0.1557	0.1548
Trichomonas vaginalis	centaurin gamma, putative	0.0078	0.0073	0.0227
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0073	0.0227
Trypanosoma cruzi	hypothetical protein	0.0078	0.0073	0.1971
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0078	0.0073	0.1971
Echinococcus granulosus	histone deacetylase 6	0.0152	0.0213	0.0242
Loa Loa (eye worm)	histone deacetylase 11	0.0152	0.0213	0.0213
Brugia malayi	Variant SH3 domain containing protein	0.0078	0.0073	0.0062
Echinococcus multilocularis	dynamin 1	0.0078	0.0073	0.0074
Brugia malayi	Immunoglobulin I-set domain containing protein	0.006	0.0038	0.0028
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0078	0.0073	0.0074
Brugia malayi	hypothetical protein	0.006	0.0038	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Schistosoma mansoni	histone deacetylase 4 5	0.0152	0.0213	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0262	0.0262
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.006	0.0038	0.0033
Schistosoma mansoni	histone deacetylase hda2	0.0152	0.0213	0.0195
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus granulosus	oxysterol binding protein 3	0.0078	0.0073	0.0074
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0078	0.0073	0.0227
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0078	0.0073	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Loa Loa (eye worm)	TK/RYK protein kinase	0.006	0.0038	0.0038
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.006	0.0038	0.002
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0066	0.0048	0.0045
Loa Loa (eye worm)	TK protein kinase	0.006	0.0038	0.0038
Brugia malayi	PH domain containing protein	0.0078	0.0073	0.0062
Trichomonas vaginalis	centaurin/arf, putative	0.0078	0.0073	0.0227
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.006	0.0038	0.002
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0405	0.0697	0.0697
Plasmodium vivax	PH domain containing protein	0.0078	0.0073	0.1971
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0078	0.0073	0.0055
Entamoeba histolytica	hypothetical protein	0.0855	0.1557	1
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Brugia malayi	Guanylyl cyclase protein 23	0.006	0.0038	0.0028
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0078	0.0073	0.1971
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Echinococcus multilocularis	c src tyrosine kinase	0.006	0.0038	0.0033
Echinococcus multilocularis	histone deacetylase 6	0.0152	0.0213	0.0242
Loa Loa (eye worm)	RGC/RGC protein kinase	0.006	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Brugia malayi	hypothetical protein	0.0078	0.0073	0.0062
Leishmania major	histone deacetylase, putative	0.0152	0.0213	1
Trypanosoma cruzi	hypothetical protein	0.0078	0.0073	0.1971
Entamoeba histolytica	protein kinase, putative	0.01	0.0113	0.0492
Brugia malayi	Histone deacetylase family protein	0.0152	0.0213	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0177	0.0262	0.1472
Schistosoma mansoni	regulator of G protein signaling	0.0855	0.1557	0.1542
Echinococcus multilocularis	tyrosine kinase	0.006	0.0038	0.0033
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0078	0.0073	0.0074
Echinococcus granulosus	axis inhibition protein axin	0.0855	0.1557	0.185
Brugia malayi	PH domain containing protein	0.0078	0.0073	0.0062
Schistosoma mansoni	growth factor receptor-bound protein	0.0078	0.0073	0.0055
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Echinococcus multilocularis	regulator of G protein signaling 7	0.0855	0.1557	0.185
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.006	0.0038	0.0033
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0083	0.0081	0.0283
Onchocerca volvulus		0.0078	0.0073	0.0201
Toxoplasma gondii	histone deacetylase HDAC1	0.0152	0.0213	1
Echinococcus multilocularis	tyrosine protein kinase	0.006	0.0038	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0083	0.0081	0.0064
Brugia malayi	SH2 domain containing protein	0.006	0.0038	0.0028
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0078	0.0073	0.0074
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0073	0.0227
Trichomonas vaginalis	histone deacetylase, putative	0.0152	0.0213	0.115
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Loa Loa (eye worm)	sema domain-containing protein	0.0405	0.0697	0.0697
Loa Loa (eye worm)	RGS-3 protein	0.0855	0.1557	0.1557
Echinococcus granulosus	Oxysterol binding protein 11	0.0078	0.0073	0.0074
Toxoplasma gondii	hypothetical protein	0.0078	0.0073	0.1971
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0855	0.1557	0.185
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.006	0.0038	0.0033
Echinococcus multilocularis	histone deacetylase 3	0.0152	0.0213	0.0242
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0855	0.1557	0.1542
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.006	0.0038	0.002
Brugia malayi	TBC domain containing protein	0.0078	0.0073	0.0062
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0078	0.0073	0.0074
Entamoeba histolytica	cell surface protease gp63, putative	0.0177	0.0262	0.1472
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0083	0.0081	0.2464
Echinococcus granulosus	twitchin	0.0135	0.0181	0.0204
Schistosoma mansoni	protein kinase	0.006	0.0038	0.002
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0405	0.0697	0.0697
Trypanosoma brucei	aurora B kinase	0.0083	0.0081	0.2464
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0114	0.0141	0.0156
Echinococcus multilocularis	regulator of G protein signaling 3	0.0855	0.1557	0.185
Loa Loa (eye worm)	uncoordinated protein 104	0.0078	0.0073	0.0073
Echinococcus multilocularis	tyrosine protein kinase csk	0.006	0.0038	0.0033
Schistosoma mansoni	voltage-gated potassium channel	0.0106	0.0126	0.0108
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0078	0.0073	0.0074
Brugia malayi	A-kinase anchor protein 10, precursor	0.0855	0.1557	0.1548
Trichomonas vaginalis	histone deacetylase, putative	0.0152	0.0213	0.115
Echinococcus granulosus	natriuretic peptide receptor 1	0.006	0.0038	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0078	0.0073	0.0074
Brugia malayi	Protein kinase domain containing protein	0.0311	0.0516	0.0506
Echinococcus multilocularis	Oxysterol binding protein 11	0.0078	0.0073	0.0074
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0078	0.0073	0.0074
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.01	0.0113	0.4278
Schistosoma mansoni	zinc finger protein	0.0078	0.0073	0.0055
Brugia malayi	regulator of G-protein signaling rgs-7	0.0855	0.1557	0.1548
Echinococcus granulosus	cytohesin 1	0.0078	0.0073	0.0074
Echinococcus granulosus	Pleckstrin y	0.0078	0.0073	0.0074
Plasmodium falciparum	histone deacetylase 2	0.0152	0.0213	1
Loa Loa (eye worm)	hypothetical protein	0.0405	0.0697	0.0697
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.0081	0.0283
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Plasmodium falciparum	histone deacetylase, putative	0.0152	0.0213	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0073	0.0227
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0078	0.0073	0.0227
Echinococcus multilocularis	tyrosine protein kinase csk	0.006	0.0038	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0855	0.1557	0.1557
Trichomonas vaginalis	conserved hypothetical protein	0.0855	0.1557	1
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Brugia malayi	plexin A	0.1133	0.2087	0.2078
Trichomonas vaginalis	histone deacetylase, putative	0.0152	0.0213	0.115
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0119	0.0151	0.0141
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Loa Loa (eye worm)	histone deacetylase	0.0152	0.0213	0.0213
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0175	0.0257	0.0246
Echinococcus granulosus	tyrosine kinase	0.006	0.0038	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0078	0.0073	0.0055
Schistosoma mansoni	serine/threonine protein kinase	0.4044	0.7647	0.7643
Trypanosoma cruzi	hypothetical protein	0.0078	0.0073	0.1971
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0082	0.0079	0.2307
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0141	0.0141
Entamoeba histolytica	PH domain containing protein	0.0078	0.0073	0.0227
Brugia malayi	hypothetical protein	0.006	0.0038	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Entamoeba histolytica	hypothetical protein	0.0855	0.1557	1
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.01	0.0113	0.0492
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.006	0.0038	0.0033
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.01	0.0113	0.4278
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0262	0.0262
Brugia malayi	hypothetical protein	0.0405	0.0697	0.0687
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.006	0.0038	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Trypanosoma cruzi	histone deacetylase, putative	0.0152	0.0213	1
Schistosoma mansoni	hypothetical protein	0.0078	0.0073	0.0055
Echinococcus multilocularis	epidermal growth factor receptor	0.006	0.0038	0.0033
Trypanosoma cruzi	hypothetical protein	0.0078	0.0073	0.1971
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0855	0.1557	0.185
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Echinococcus granulosus	histone deacetylase	0.0152	0.0213	0.0242
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0078	0.0073	0.1971
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0126	0.0126
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0078	0.0073	0.0074
Schistosoma mansoni	plexin	0.0956	0.1748	0.1733
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0114	0.0141	0.0123
Echinococcus multilocularis	tyrosine protein kinase csk	0.006	0.0038	0.0033
Plasmodium falciparum	histone deacetylase 1	0.0152	0.0213	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Schistosoma mansoni	hypothetical protein	0.0405	0.0697	0.068
Schistosoma mansoni	hypothetical protein	0.055	0.0974	0.0958
Trypanosoma cruzi	histone deacetylase 1, putative	0.0152	0.0213	1
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus multilocularis	regulator of G protein signaling 3	0.0855	0.1557	0.185
Echinococcus multilocularis	semaphorin 5B	0.0405	0.0697	0.0821
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0855	0.1557	0.1542
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0078	0.0073	0.0062
Schistosoma mansoni	serine/threonine protein kinase	0.4044	0.7647	0.7643
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Schistosoma mansoni	regulator of G protein signaling	0.0855	0.1557	0.1542
Entamoeba histolytica	protein kinase, putative	0.01	0.0113	0.0492
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Leishmania major	histone deacetylase, putative	0.0152	0.0213	1
Echinococcus multilocularis	plexin a4	0.1133	0.2087	0.2485
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0082	0.0079	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0262	0.0262
Echinococcus multilocularis	expressed protein	0.0855	0.1557	0.185
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0078	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Schistosoma mansoni	histone deacetylase 4 5	0.0152	0.0213	0.0195
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.006	0.0038	0.0038
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus granulosus	epidermal growth factor receptor	0.006	0.0038	0.0033
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0078	0.0073	0.0227
Brugia malayi	Raf kinase	0.006	0.0038	0.0028
Brugia malayi	hypothetical protein	0.0855	0.1557	0.1548
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0078	0.0073	0.0074
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.006	0.0038	0.002
Trichomonas vaginalis	centaurin alpha, putative	0.0078	0.0073	0.0227
Entamoeba histolytica	hypothetical protein	0.0177	0.0262	0.1472
Echinococcus multilocularis	ephrin type A receptor 4 A	0.006	0.0038	0.0033
Echinococcus granulosus	retinal guanylyl cyclase 2	0.006	0.0038	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Brugia malayi	Receptor family ligand binding region containing protein	0.006	0.0038	0.0028
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0141	0.0141
Echinococcus granulosus	tyrosine protein kinase HCK	0.006	0.0038	0.0033
Entamoeba histolytica	hypothetical protein	0.0855	0.1557	1
Brugia malayi	Fibronectin type III domain containing protein	0.0119	0.0151	0.0141
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.006	0.0038	0.0038
Toxoplasma gondii	protein kinase domain-containing protein	0.01	0.0113	0.4278
Schistosoma mansoni	plexin	0.055	0.0974	0.0958
Brugia malayi	histone deacetylase 1 (HD1)	0.0152	0.0213	0.0203
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.006	0.0038	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0405	0.0697	0.0697
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.4044	0.7647	0.7647
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus multilocularis	oxysterol binding protein 3	0.0078	0.0073	0.0074
Loa Loa (eye worm)	PXA domain-containing protein	0.0855	0.1557	0.1557
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.006	0.0038	0.0033
Brugia malayi	serine/threonine protein kinase 6	0.0083	0.0081	0.0071
Loa Loa (eye worm)	RGC/RGC protein kinase	0.006	0.0038	0.0038
Toxoplasma gondii	histone deacetylase HDAC2	0.0152	0.0213	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.006	0.0038	0.0033
Entamoeba histolytica	hypothetical protein, conserved	0.0078	0.0073	0.0227
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0078	0.0073	0.0227
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0113	0.0492
Echinococcus multilocularis	Pleckstrin y	0.0078	0.0073	0.0074
Loa Loa (eye worm)	TK protein kinase	0.006	0.0038	0.0038
Brugia malayi	PH domain containing protein	0.0078	0.0073	0.0062
Plasmodium falciparum	oxysterol-binding protein, putative	0.0078	0.0073	0.1971
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Entamoeba histolytica	hypothetical protein	0.0177	0.0262	0.1472
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.006	0.0038	0.0033
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0177	0.0262	0.1472
Schistosoma mansoni	protein kinase	0.006	0.0038	0.002
Plasmodium vivax	histone deacetylase, putative	0.0152	0.0213	1
Trichomonas vaginalis	histone deacetylase, putative	0.0152	0.0213	0.115
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.006	0.0038	0.0028
Onchocerca volvulus	Putative zinc finger protein	0.0078	0.0073	0.0201
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0405	0.0697	0.0697
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.01	0.0113	0.4278
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Echinococcus granulosus	beta 1 syntrophin	0.0078	0.0073	0.0074
Loa Loa (eye worm)	rho-GTPase-activating	0.0078	0.0073	0.0073
Echinococcus multilocularis	regulator of G protein signaling 7	0.0855	0.1557	0.185
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Loa Loa (eye worm)	TK/ALK protein kinase	0.0311	0.0516	0.0516
Brugia malayi	ephrin receptor 1 precursor	0.006	0.0038	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.006	0.0038	0.0028
Echinococcus granulosus	regulator of G protein signaling 7	0.0855	0.1557	0.185
Echinococcus granulosus	expressed protein	0.0855	0.1557	0.185
Schistosoma mansoni	semaphorin 5-related	0.0405	0.0697	0.068
Echinococcus granulosus	calcium dependent secretion activator 1	0.0078	0.0073	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus multilocularis	activated cdc42 kinase 1	0.006	0.0038	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.006	0.0038	0.0038
Brugia malayi	Furin-like cysteine rich region family protein	0.006	0.0038	0.0028
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0038	0.002
Brugia malayi	Oxysterol binding protein	0.0078	0.0073	0.0062
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Schistosoma mansoni	protein kinase	0.006	0.0038	0.002
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.4421	0.8366	1
Trichomonas vaginalis	centaurin beta, putative	0.0078	0.0073	0.0227
Echinococcus granulosus	pleckstrin y domain containing family A	0.0078	0.0073	0.0074
Entamoeba histolytica	PH domain containing protein	0.0078	0.0073	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0151	0.0151
Echinococcus granulosus	histone deacetylase 7	0.0152	0.0213	0.0242
Echinococcus multilocularis	histone deacetylase 8	0.0152	0.0213	0.0242
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Brugia malayi	serine/threonine kinase 12	0.0083	0.0081	0.0071
Loa Loa (eye worm)	TK/ABL protein kinase	0.006	0.0038	0.0038
Trypanosoma brucei	PH domain containing protein, putative	0.0078	0.0073	0.1971
Loa Loa (eye worm)	TK protein kinase	0.006	0.0038	0.0038
Echinococcus multilocularis	protein kinase	0.006	0.0038	0.0033
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Loa Loa (eye worm)	TK/ACK protein kinase	0.006	0.0038	0.0038
Echinococcus granulosus	tyrosine protein kinase Blk	0.006	0.0038	0.0033
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0078	0.0073	0.0227
Echinococcus multilocularis	tyrosine protein kinase Blk	0.006	0.0038	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Loa Loa (eye worm)	AUR protein kinase	0.0083	0.0081	0.0081
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.006	0.0038	0.0033
Echinococcus multilocularis	histone deacetylase 6	0.0152	0.0213	0.0242
Echinococcus granulosus	defective proboscis extension response	0.0114	0.0141	0.0156
Echinococcus multilocularis	tyrosine protein kinase HCK	0.006	0.0038	0.0033
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.006	0.0038	0.0033
Onchocerca volvulus		0.0078	0.0073	0.0201
Entamoeba histolytica	hypothetical protein	0.0078	0.0073	0.0227
Schistosoma mansoni	serine/threonine RGC	0.006	0.0038	0.002
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.01	0.0113	0.4278
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus granulosus	Pleckstrin y	0.0078	0.0073	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0213	0.0213
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0078	0.0073	0.0227
Echinococcus granulosus	tyrosine protein kinase csk	0.006	0.0038	0.0033
Trypanosoma brucei	histone deacetylase 3	0.0152	0.0213	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.006	0.0038	0.0033
Schistosoma mansoni	centaurin alpha	0.0078	0.0073	0.0055
Toxoplasma gondii	hypothetical protein	0.0078	0.0073	0.1971
Plasmodium vivax	histone deacetylase 2, putative	0.0152	0.0213	1
Leishmania major	protein kinase, putative	0.01	0.0113	0.4278
Loa Loa (eye worm)	plexin A	0.1133	0.2087	0.2087
Schistosoma mansoni	zinc finger protein	0.0078	0.0073	0.0055
Echinococcus granulosus	tyrosine protein kinase Src64B	0.006	0.0038	0.0033
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0073	0.0227
Entamoeba histolytica	protein kinase , putative	0.0083	0.0081	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0078	0.0073	0.0201
Brugia malayi	MAX-1A	0.0078	0.0073	0.0062
Loa Loa (eye worm)	RGC/RGC protein kinase	0.006	0.0038	0.0038
Brugia malayi	PH domain containing protein	0.0078	0.0073	0.0062
Echinococcus granulosus	serine/threonine protein kinase	0.01	0.0113	0.0123
Echinococcus granulosus	oxysterol binding protein 9	0.0078	0.0073	0.0074
Echinococcus granulosus	semaphorin 5B	0.0405	0.0697	0.0821
Echinococcus multilocularis	aurora kinase A	0.0083	0.0081	0.0085
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Leishmania major	hypothetical protein, conserved	0.0078	0.0073	0.1971
Entamoeba histolytica	protein kinase, putative	0.0083	0.0081	0.0283
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0078	0.0073	0.0074
Entamoeba histolytica	protein kinase, putative	0.01	0.0113	0.0492
Brugia malayi	Uncoordinated protein 104	0.0078	0.0073	0.0062
Schistosoma mansoni	dynamin	0.0078	0.0073	0.0055
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.01	0.0113	0.4278
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0078	0.0073	0.1971
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0141	0.0141
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0078	0.0073	0.0062
Onchocerca volvulus		0.0078	0.0073	0.0201
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.006	0.0038	0.0033
Echinococcus multilocularis	tyrosine kinase	0.006	0.0038	0.0033
Brugia malayi	serine/threonine-protein kinase 6	0.0083	0.0081	0.0071
Echinococcus granulosus	DCC interacting protein 13 beta	0.0078	0.0073	0.0074
Trypanosoma cruzi	NIMA-related kinase, putative	0.01	0.0113	0.4278
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0078	0.0073	0.1971
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0078	0.0073	0.0074
Schistosoma mansoni	voltage-gated potassium channel	0.0106	0.0126	0.0108
Echinococcus multilocularis	activin receptor type	0.0082	0.0079	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0152	0.0213	0.115
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.006	0.0038	0.0033
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.006	0.0038	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Leishmania major	protein kinase, putative	0.01	0.0113	0.4278
Echinococcus multilocularis	transfer RNA-Thr	0.006	0.0038	0.0033
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0113	0.0492
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0038	0.002
Onchocerca volvulus	outspread protein homolog	0.0078	0.0073	0.0201
Echinococcus multilocularis	potassium voltage gated channel protein	0.0106	0.0126	0.0138
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.006	0.0038	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0855	0.1557	1
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus granulosus	dynamin 1	0.0078	0.0073	0.0074
Loa Loa (eye worm)	TK protein kinase	0.006	0.0038	0.0038
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.006	0.0038	0.0033
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.006	0.0038	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0177	0.0262	0.1472
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.006	0.0038	0.0033
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.006	0.0038	0.002
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Trichomonas vaginalis	AGC family protein kinase	0.0083	0.0081	0.0283
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0078	0.0073	0.0074
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0078	0.0073	0.0227
Echinococcus multilocularis	tyrosine protein kinase Srms	0.006	0.0038	0.0033
Brugia malayi	bone morphogenetic protein type 1 receptor	0.006	0.0038	0.0028
Giardia lamblia	Histone deacetylase	0.0152	0.0213	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.01	0.0113	0.4278
Entamoeba histolytica	hypothetical protein	0.0078	0.0073	0.0227
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Trichomonas vaginalis	AGC family protein kinase	0.0083	0.0081	0.0283
Loa Loa (eye worm)	TK protein kinase	0.006	0.0038	0.0038
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0078	0.0073	0.1971
Schistosoma mansoni	protein kinase	0.006	0.0038	0.002
Echinococcus granulosus	protein tyrosine kinase	0.006	0.0038	0.0033
Entamoeba histolytica	hypothetical protein	0.0078	0.0073	0.0227
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0855	0.1557	1
Brugia malayi	Pleckstrin Homology Domain	0.0078	0.0073	0.0062
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Brugia malayi	Cadps2 protein	0.0078	0.0073	0.0062
Trypanosoma cruzi	hypothetical protein	0.0078	0.0073	0.1971
Plasmodium vivax	hypothetical protein, conserved	0.0078	0.0073	0.1971
Echinococcus multilocularis	insulin receptor	0.006	0.0038	0.0033
Brugia malayi	Tyrosine-protein kinase abl-1	0.006	0.0038	0.0028
Schistosoma mansoni	hypothetical protein	0.0078	0.0073	0.0055
Echinococcus granulosus	regulator of G protein signaling 3	0.0855	0.1557	0.185
Brugia malayi	Cytohesin 3	0.0078	0.0073	0.0062
Giardia lamblia	Aurora kinase	0.0083	0.0081	0.2464
Entamoeba histolytica	hypothetical protein	0.0078	0.0073	0.0227
Echinococcus granulosus	myotubularin protein 13	0.0078	0.0073	0.0074
Toxoplasma gondii	aurora kinase	0.0083	0.0081	0.2464
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0083	0.0081	0.0283
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.006	0.0038	0.0033
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0175	0.0257	0.0257
Schistosoma mansoni	protein kinase	0.0082	0.0079	0.0061
Trypanosoma cruzi	hypothetical protein	0.0078	0.0073	0.1971
Loa Loa (eye worm)	cytohesin 3	0.0078	0.0073	0.0073
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0038	0.002
Trypanosoma brucei	histone deacetylase 1	0.0152	0.0213	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.006	0.0038	0.0038
Schistosoma mansoni	protein kinase	0.0083	0.0081	0.0064
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.006	0.0038	0.0028
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.01	0.0113	0.4278
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0855	0.1557	0.1542
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.006	0.0038	0.0033
Schistosoma mansoni	hypothetical protein	0.0078	0.0073	0.0055
Echinococcus granulosus	regulator of G protein signaling 3	0.0855	0.1557	0.185
Onchocerca volvulus		0.0078	0.0073	0.0201
Trichomonas vaginalis	conserved hypothetical protein	0.0177	0.0262	0.1472
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0078	0.0073	0.0062
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus multilocularis	hypothetical protein	0.0405	0.0697	0.0821
Echinococcus granulosus	beta-adrenergic receptor kinase	0.4044	0.7647	0.914
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0114	0.0141	0.0123
Schistosoma mansoni	fibrocystin l	0.0177	0.0262	0.0244
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus multilocularis	roundabout 2	0.0119	0.0151	0.0168
Echinococcus multilocularis	exocyst complex component 2	0.0177	0.0262	0.0301
Echinococcus multilocularis	oxysterol binding protein 9	0.0078	0.0073	0.0074
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.006	0.0038	0.0033
Echinococcus multilocularis	tyrosine protein kinase shark	0.006	0.0038	0.0033
Brugia malayi	DNA-binding protein LAG-1	0.0177	0.0262	0.0252
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus multilocularis	beta 1 syntrophin	0.0078	0.0073	0.0074
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.01	0.0113	0.4278
Echinococcus multilocularis	epidermal growth factor receptor	0.006	0.0038	0.0033
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0078	0.0073	0.0074
Trichomonas vaginalis	kinesin light chain, putative	0.0078	0.0073	0.0227
Brugia malayi	histone deacetylase 3 (HD3)	0.0152	0.0213	0.0203
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Onchocerca volvulus	Protein melted homolog	0.0078	0.0073	0.0201
Echinococcus granulosus	ephrin type A receptor 4 A	0.006	0.0038	0.0033
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0082	0.0079	0.2307
Trichomonas vaginalis	protein transport protein sec7, putative	0.0078	0.0073	0.0227
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0078	0.0073	0.1971
Echinococcus granulosus	tyrosine kinase	0.006	0.0038	0.0033
Leishmania major	histone deacetylase, putative	0.0152	0.0213	1
Echinococcus granulosus	histone deacetylase 1	0.0152	0.0213	0.0242
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.006	0.0038	0.0033
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0073	0.0227
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0152	0.0213	0.115
Loa Loa (eye worm)	histone deacetylase 7A	0.0152	0.0213	0.0213
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.01	0.0113	0.4278
Echinococcus multilocularis	oxysterol binding protein 1	0.0078	0.0073	0.0074
Echinococcus granulosus	aurora kinase A	0.0083	0.0081	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0855	0.1557	0.1557
Loa Loa (eye worm)	SRC-1	0.006	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0151	0.0151
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Schistosoma mansoni	protein kinase	0.006	0.0038	0.002
Loa Loa (eye worm)	hypothetical protein	0.0956	0.1748	0.1748
Loa Loa (eye worm)	serine/threonine protein kinase	0.006	0.0038	0.0038
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.006	0.0038	0.0033
Schistosoma mansoni	histone deacetylase	0.0152	0.0213	0.0195
Schistosoma mansoni	dynamin	0.0078	0.0073	0.0055
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Echinococcus granulosus	exocyst complex component 2	0.0177	0.0262	0.0301
Loa Loa (eye worm)	PH domain-containing protein	0.0078	0.0073	0.0073
Toxoplasma gondii	Oxysterol-binding protein	0.0078	0.0073	0.1971
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.006	0.0038	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0038	0.002
Echinococcus multilocularis	neuroglian	0.0114	0.0141	0.0156
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Echinococcus granulosus	histone deacetylase 8	0.0152	0.0213	0.0242
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Echinococcus multilocularis	pdz domain containing protein	0.0078	0.0073	0.0074
Brugia malayi	Dynamin	0.0078	0.0073	0.0062
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.006	0.0038	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0177	0.0262	0.1472
Schistosoma mansoni	serine/threonine-protein kinase	0.01	0.0113	0.0095
Leishmania major	protein kinase, putative	0.0083	0.0081	0.2464
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Trypanosoma cruzi	NIMA-related kinase, putative	0.01	0.0113	0.4278
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.5276	1	1
Toxoplasma gondii	AtPH1 family protein	0.0078	0.0073	0.1971
Loa Loa (eye worm)	AGC/AKT protein kinase	0.01	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0151	0.0151
Echinococcus granulosus	pdz domain containing protein	0.0078	0.0073	0.0074
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Schistosoma mansoni	serine/threonine protein kinase	0.5276	1	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.006	0.0038	0.0038
Brugia malayi	histone deacetylase 11	0.0152	0.0213	0.0203
Echinococcus granulosus	epidermal growth factor receptor	0.006	0.0038	0.0033
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0078	0.0073	0.0227
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Echinococcus granulosus	tyrosine protein kinase	0.006	0.0038	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0141	0.0141
Echinococcus multilocularis	heat shock protein 70	0.006	0.0038	0.0033
Schistosoma mansoni	rho gtpase activating protein	0.0078	0.0073	0.0055
Trichomonas vaginalis	histone deacetylase, putative	0.0152	0.0213	0.115
Trichomonas vaginalis	protein transport protein sec7, putative	0.0078	0.0073	0.0227
Echinococcus multilocularis	protein tyrosine kinase	0.006	0.0038	0.0033
Brugia malayi	IPT/TIG domain containing protein	0.0177	0.0262	0.0252
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.006	0.0038	0.0033
Schistosoma mansoni	hypothetical protein	0.0177	0.0262	0.0244
Entamoeba histolytica	protein kinase, putative	0.01	0.0113	0.0492
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0082	0.0079	0.2307
Schistosoma mansoni	protein kinase	0.006	0.0038	0.002
Trichomonas vaginalis	centaurin/arf, putative	0.0078	0.0073	0.0227
Entamoeba histolytica	tyrosin kinase, putative	0.0238	0.0377	0.2232
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Echinococcus granulosus	activated cdc42 kinase 1	0.006	0.0038	0.0033
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0078	0.0073	0.0074
Onchocerca volvulus		0.0078	0.0073	0.0201
Echinococcus granulosus	G protein coupled receptor kinase 1	0.3189	0.6013	0.7184
Brugia malayi	PXA domain containing protein	0.0855	0.1557	0.1548
Echinococcus granulosus	semaphorin 1A	0.0405	0.0697	0.0821
Toxoplasma gondii	histone deacetylase HDAC3	0.0152	0.0213	1
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0113	0.0492
Schistosoma mansoni	myotubularin-related protein	0.0078	0.0073	0.0055
Brugia malayi	hypothetical protein	0.0119	0.0151	0.0141
Echinococcus granulosus	protein kinase	0.006	0.0038	0.0033
Schistosoma mansoni	nephrin	0.0119	0.0151	0.0133
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.006	0.0038	0.0028
Schistosoma mansoni	hypothetical protein	0.006	0.0038	0.002
Echinococcus granulosus	receptor type guanylyl cyclase	0.006	0.0038	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0855	0.1557	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0213	0.0213
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus multilocularis	receptor type guanylyl cyclase	0.006	0.0038	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Schistosoma mansoni	regulator of G protein signaling	0.0855	0.1557	0.1542
Brugia malayi	hypothetical protein	0.0855	0.1557	0.1548
Loa Loa (eye worm)	sema domain-containing protein	0.0405	0.0697	0.0697
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0855	0.1557	0.1548
Brugia malayi	Sema domain containing protein	0.0405	0.0697	0.0687
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus granulosus	transcription factor collier	0.0177	0.0262	0.0301
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0078	0.0073	0.0074
Onchocerca volvulus		0.0078	0.0073	0.0201
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0083	0.0081	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus multilocularis	axis inhibition protein axin	0.0855	0.1557	0.185
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Brugia malayi	C-terminal src kinase protein 1	0.006	0.0038	0.0028
Schistosoma mansoni	hypothetical protein	0.0078	0.0073	0.0055
Entamoeba histolytica	protein kinase, putative	0.01	0.0113	0.0492
Leishmania major	histone deacetylase, putative	0.0152	0.0213	1
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0078	0.0073	0.0055
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0083	0.0081	0.2464
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.4421	0.8366	0.8366
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0083	0.0081	0.0085
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0113	0.0492
Loa Loa (eye worm)	oxysterol binding protein	0.0078	0.0073	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0855	0.1557	1
Brugia malayi	PH domain containing protein	0.0078	0.0073	0.0062
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.01	0.0113	0.4278
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0073	0.0227
Schistosoma mansoni	syntrophin	0.0078	0.0073	0.0055
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0078	0.0073	0.0074
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.01	0.0113	0.4278
Brugia malayi	Oxysterol-binding protein	0.0078	0.0073	0.0062
Schistosoma mansoni	histone deacetylase	0.0152	0.0213	0.0195
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.006	0.0038	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0855	0.1557	0.1557
Echinococcus granulosus	insulin receptor	0.006	0.0038	0.0033
Schistosoma mansoni	oxysterol-binding protein 1	0.0078	0.0073	0.0055
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0078	0.0073	0.0227
Loa Loa (eye worm)	TK/ROR protein kinase	0.006	0.0038	0.0038
Echinococcus multilocularis	FL cytokine receptor	0.006	0.0038	0.0033
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0078	0.0073	0.0074
Entamoeba histolytica	protein kinase domain containing protein	0.0082	0.0079	0.0265
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.006	0.0038	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0855	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0073	0.0073
Echinococcus granulosus	neuroglian	0.0114	0.0141	0.0156
Echinococcus multilocularis	tyrosine protein kinase Abl	0.006	0.0038	0.0033
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Schistosoma mansoni	goodpasture antigen-binding protein	0.0078	0.0073	0.0055
Echinococcus multilocularis	Immunoglobulin	0.0114	0.0141	0.0156
Schistosoma mansoni	serine/threonine-protein kinase	0.01	0.0113	0.0095
Plasmodium falciparum	protein kinase, putative	0.0082	0.0079	0.2307
Trypanosoma cruzi	PH domain containing protein, putative	0.0078	0.0073	0.1971
Schistosoma mansoni	regulator of G protein signaling	0.0855	0.1557	0.1542
Trypanosoma cruzi	histone deacetylase 1, putative	0.0152	0.0213	1
Echinococcus granulosus	roundabout 2	0.0119	0.0151	0.0168
Echinococcus granulosus	tyrosine protein kinase Srms	0.006	0.0038	0.0033
Leishmania major	folate/biopterin transporter, putative	0.01	0.0113	0.4278
Brugia malayi	Histone deacetylase family protein	0.0152	0.0213	0.0203
Schistosoma mansoni	histone deacetylase hda2	0.0152	0.0213	0.0195
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0083	0.0081	0.0283
Entamoeba histolytica	hypothetical protein	0.0078	0.0073	0.0227
Echinococcus multilocularis	Immunoglobulin	0.0114	0.0141	0.0156
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0078	0.0073	0.0074
Brugia malayi	Protein kinase domain containing protein	0.006	0.0038	0.0028
Toxoplasma gondii	histone deacetylase HDAC5	0.0152	0.0213	1
Entamoeba histolytica	p21-activated kinase	0.01	0.0113	0.0492
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.01	0.0113	0.4278
Echinococcus granulosus	retinal guanylyl cyclase 2	0.006	0.0038	0.0033
Echinococcus multilocularis	tyrosine protein kinase pr2	0.006	0.0038	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0078	0.0073	0.0227
Echinococcus multilocularis	beta adrenergic receptor kinase	0.4044	0.7647	0.914
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Echinococcus granulosus	Rho GTPase activating protein 24	0.0078	0.0073	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Schistosoma mansoni	cell adhesion molecule	0.0119	0.0151	0.0133
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.4421	0.8366	0.8364
Entamoeba histolytica	hypothetical protein	0.0177	0.0262	0.1472
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Plasmodium vivax	histone deacetylase, putative	0.0152	0.0213	1
Echinococcus granulosus	activin receptor type	0.0082	0.0079	0.0081
Echinococcus granulosus	axis inhibition protein axin	0.0855	0.1557	0.185
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Brugia malayi	SRC-1	0.006	0.0038	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0038	0.0038
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0073	0.0227
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0177	0.0262	0.1472
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.006	0.0038	0.002
Entamoeba histolytica	hypothetical protein	0.01	0.0113	0.0492
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.01	0.0113	0.4278
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.006	0.0038	0.0038
Echinococcus granulosus	activated cdc42 kinase 1	0.006	0.0038	0.0033
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0078	0.0073	0.0201
Trypanosoma cruzi	aurora B kinase, putative	0.0083	0.0081	0.2464
Echinococcus granulosus	Immunoglobulin	0.0114	0.0141	0.0156
Schistosoma mansoni	oxysterol-binding protein 1	0.0078	0.0073	0.0055
Echinococcus multilocularis	myotubularin protein 13	0.0078	0.0073	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.006	0.0038	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0855	0.1557	1
Loa Loa (eye worm)	Plekhf2 protein	0.0078	0.0073	0.0073
Schistosoma mansoni	vav2	0.0078	0.0073	0.0055
Plasmodium vivax	histone deacetylase 1, putative	0.0152	0.0213	1
Entamoeba histolytica	protein kinase, putative	0.01	0.0113	0.0492
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0106	0.0126	0.0116
Plasmodium falciparum	PH domain-containing protein, putative	0.0078	0.0073	0.1971
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Schistosoma mansoni	tyrosine kinase	0.006	0.0038	0.002
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0177	0.0262	0.1472
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0082	0.0079	0.2307
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0073	0.0227
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0152	0.0213	0.1021
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0113	0.0492
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0078	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.022	0.0343	0.0343
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus granulosus	tyrosine protein kinase Fyn	0.006	0.0038	0.0033
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.006	0.0038	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0141	0.0141
Echinococcus granulosus	retinal guanylyl cyclase 2	0.006	0.0038	0.0033
Loa Loa (eye worm)	histone deacetylase 1	0.0152	0.0213	0.0213
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0082	0.0079	0.0081
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0177	0.0262	0.1472
Onchocerca volvulus		0.0956	0.1748	1
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0078	0.0073	0.0074
Trypanosoma cruzi	PH domain containing protein, putative	0.0078	0.0073	0.1971
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0113	0.0492
Echinococcus granulosus	histone deacetylase 6	0.0152	0.0213	0.0242
Loa Loa (eye worm)	hypothetical protein	0.006	0.0038	0.0038
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.006	0.0038	0.0028
Echinococcus multilocularis	histone deacetylase 6	0.0152	0.0213	0.0242
Trypanosoma brucei	protein kinase, putative	0.01	0.0113	0.4278

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.159 uM	Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique	ChEMBL.	19004630
Inhibition (binding)	= 59 %	Inhibition of human Kv1.5 channel expressed in Xenopus oocytes at 3 uM by EP voltage clamp technique	ChEMBL.	19004630

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL479618

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 979944