pI: 6.0071 |
Length (AA): 1649 |
MW (Da): 188445 |
Paralog Number:
9
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_130635)
Species | Accession | Gene Product |
---|---|---|
Leishmania braziliensis | LbrM.27.0610 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania braziliensis | LbrM.27.0620 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania braziliensis | LbrM.27.2140 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania braziliensis | LbrM.27.0600 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania donovani | LdBPK_270510.1 | calpain-like cysteine peptidase, putative |
Leishmania infantum | LinJ.27.0500 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania infantum | LinJ.27.2520 | cysteine peptidase, Clan CA, family C2, putative |
Leishmania infantum | LinJ.27.2490 | calpain-like cysteine peptidase |
Leishmania infantum | LinJ.27.0510 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania major | LmjF.27.0490 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania major | LmjF.27.0500 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania major | LmjF.27.0510 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania mexicana | LmxM.27.0500 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania mexicana | LmxM.27.0490 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Leishmania mexicana | LmxM.27.0510 | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative |
Trypanosoma brucei gambiense | Tbg972.11.1180 | calpain-like protein, putative |
Trypanosoma brucei gambiense | Tbg972.11.1190 | calpain-like cysteine peptidase, putative,antigen, putative,cysteine peptidase, Clan CA, family C2, putative |
Trypanosoma brucei gambiense | Tbg972.11.1170 | |
Trypanosoma brucei | Tb11.v5.0432 | calpain-like cysteine peptidase, putative |
Trypanosoma brucei | Tb927.11.1130 | calpain-like cysteine peptidase, putative |
Trypanosoma brucei | Tb427tmp.11.0001 | hypothetical protein |
Trypanosoma brucei | Tb11.v5.1010 | variant surface glycoprotein (VSG), putative |
Trypanosoma brucei | Tb927.11.1090 | calpain-like protein, putative |
Trypanosoma brucei | Tb11.v5.1011 | calpain-like cysteine peptidase, putative |
Trypanosoma brucei | Tb11.v5.1038 | calpain-like cysteine peptidase, putative |
Trypanosoma brucei | Tb927.11.1100 | cysteine peptidase, Clan CA, family C2, putative |
Trypanosoma brucei | Tb927.11.1110 | calpain, putative |
Trypanosoma brucei | Tb11.v5.0702 | calpain-like cysteine peptidase, putative |
Trypanosoma congolense | TcIL3000.11.1030 | cysteine peptidase, Clan CA, family C2, putative |
Trypanosoma congolense | TcIL3000_0_11260 | calpain, putative |
Trypanosoma cruzi | TcCLB.511445.10 | calpain-like cysteine peptidase, putative |
Trypanosoma cruzi | TcCLB.511441.10 | calpain cysteine peptidase, putative |
Trypanosoma cruzi | TcCLB.509013.10 | calpain-like cysteine peptidase, putative |
Trypanosoma cruzi | TcCLB.445281.9 | calpain-like cysteine peptidase, putative |
Trypanosoma cruzi | TcCLB.506721.30 | cysteine peptidase, Clan CA, family C2, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.v4.0001 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.v4.0001 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.v4.0001 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.v4.0001 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.47.0036 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.47.0036 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.47.0036 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.47.0036 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.47.0035 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.47.0035 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.47.0035 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.47.0035 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.57.0008 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.57.0008 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.57.0008 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.57.0008 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | Compounds | References |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | Compounds | References |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | Compounds | References |
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 REV | Compounds | References |
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) | Protein Rev | Compounds | References |
1 literature reference was collected for this gene.