Detailed view for LmjF.35.1220

Basic information

TDR Targets ID: 25708
Leishmania major, short chain dehydrogenase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.9524 | Length (AA): 233 | MW (Da): 24875 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00106   short chain dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 233 1sny (A) 2 248 30.00 0 1 1.21 -0.42
2 230 1zem (A) 8 262 26.00 0 1 1.28 -1.15
2 230 1nff (A) 8 237 28.00 0 1 1.36 -0.95
1 233 1wma (A) 4 276 30.00 0 1 1.2039 -0.58
2 225 4trr (E) 7 252 27.00 0.000000002 1 1.32597 -0.76
2 226 3o26 (A) 13 304 36.00 0 1 1.03947 -0.76
2 191 1w6u (A) 60 245 28.00 0.0000024 1 1.11805 -0.44
2 222 5jla (A) 10 237 28.00 0 1 1.2704 -1.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_126860)

Species Accession Gene Product
Arabidopsis thaliana AT4G20760   Rossmann-fold NAD(P)-binding domain-containing protein
Caenorhabditis elegans CELE_F20G2.2   Protein F20G2.2
Caenorhabditis elegans CELE_K08F4.9   Protein DHS-12
Caenorhabditis elegans CELE_C55A6.5   Protein SDZ-8
Caenorhabditis elegans CELE_C55A6.6   Protein C55A6.6
Caenorhabditis elegans CELE_F20G2.1   Protein F20G2.1
Caenorhabditis elegans CELE_C55A6.3   Protein C55A6.3
Caenorhabditis elegans CELE_C30G12.2   Protein C30G12.2
Caenorhabditis elegans CELE_C55A6.4   Protein C55A6.4
Caenorhabditis elegans CELE_ZK697.14   Protein ZK697.14
Caenorhabditis elegans CELE_C55A6.7   Protein C55A6.7
Drosophila melanogaster Dmel_CG10964   sniffer
Leishmania braziliensis LbrM.34.1140   short chain dehydrogenase, putative
Leishmania donovani LdBPK_351230.1   short chain dehydrogenase, putative
Leishmania infantum LinJ.35.1230   short chain dehydrogenase, putative
Leishmania major LmjF.35.1220   short chain dehydrogenase, putative
Leishmania mexicana LmxM.34.1220   short chain dehydrogenase, putative
Oryza sativa 4352758   Os12g0609500
Saccharomyces cerevisiae YKL071W   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.4

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Macaca mulatta Hydroxysteroid 11-beta dehydrogenase 1 140 aa 28.8% 139 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0114 1 1
0.0021 0.5 0.5
0.0004 0.5 0.5
0.0032 1 1
0.007 0.2916 1
0.0089 0.5 0.5
0.0053 1 1
0.0097 0.4304 1
0.0102 0.7451 0.5
0.0087 0.5 0.5
0.0165 1 1
0.0218 0.5 0.5
0.0058 0.3931 1
0.0009 0.5 0.5
0.0196 0.8679 0.5
0.0084 0.4283 0.4047
0.0408 0.5144 1
0.0016 0.5 0.5
0.0118 1 1
0.0004 0.5 0.5
0.0027 0.5 0.5
0.0012 0.5 0.5
0.0113 1 1
0.007 1 1
0.0004 0.5 0.5
0.0119 0.2746 1
0.0089 0.5 0.5
0.0009 1 0.5
0.007 0.2916 1
0.0073 0.2873 0.4086
0.0009 0.5 0.5
0.0009 0.5 0.5
0.0013 0.5 0.5
0.0088 0.6544 1
0.007 1 1
0.0108 0.5 0.5
0.0408 0.5144 1
0.0067 0.3468 1
0.0004 0.5 0.5
0.0162 1 1
0.008 0.5 0.5
0.0064 0.3508 0.5
0.0114 1 1
0.0196 0.8679 0.5
0.0045 1 1
0.0004 0.5 0.5
0.0005 0.5 0.5
0.0009 0.5 0.5
0.0157 0.5 0.5
0.0088 1 1
0.0076 1 1
0.0009 0.5 0.5
0.0021 0.3321 0.5
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0106 0.2872 1
0.0073 0.3811 1
0.0106 1 0.5
0.0171 0.4063 0.5
0.0053 1 1
0.0009 0.5 0.5
0.0131 0.5 0.5
0.0408 0.5144 1
0.007 0.2916 1
0.0073 0.4546 1
0.0106 1 1
0.0222 0.5 0.5
0.0058 1 1
0.0057 0.284 0.6352
0.0123 0.5 0.5
0.0046 0.3082 0
0.0132 0.3658 1
0.0071 0.3141 0
0.007 1 1
0.0035 1 1
0.016 0.577 1
0.004 0.5 0.5
0.0056 0.875 1
0.0005 0.5 0.5
0.0068 1 1
0.0068 0.2585 0.5
0.0066 0.3586 0.5
0.0021 0.3321 0.5
0.0082 1 0.5
0.011 0.3568 0.5973
0.0026 0.5 0.5
0.0009 0.5 0.5
0.0039 1 1
0.0106 0.5 0.5
0.0009 0.7374 0.5
0.0073 0.3141 1
0.0013 1 0.5
0.0019 0.4322 1
0.0009 0.5 0.5
0.0004 0.5 0.5
0.0085 1 1
0.0171 0.4063 0.5
0.0027 0.5 0.5
0.0056 1 1
0.0402 1 1
0.0073 0.3811 1
0.016 0.577 1
0.0068 1 1
0.0097 1 1
0.0196 0.8679 0.5
0.0093 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Lmaj00463AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Lmaj00463; Recombinant protein: full-length; Source: L major; short chain dehydrogenase putative; old ID AAG10805 ;

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.35.1220 (Leishmania major), short chain dehydrogenase, putative
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