pI: 8.1044 |
Length (AA): 989 |
MW (Da): 112736 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
11 | 345 | 3uwp (A) | 11 | 343 | 54.00 | 0 | 1 | 1.05243 | -1.04 |
783 | 972 | 5vjt (A) | 2 | 194 | 12.00 | 0.29 | 0.08 | 0.379513 | -1.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130680)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_56955 | Histone-lysine N-methyltransferase, H3 lysine-79 specific |
Caenorhabditis elegans | CELE_F55G7.2 | Protein F55G7.2 |
Caenorhabditis elegans | CELE_Y39G10AR.18 | Protein Y39G10AR.18, isoform B |
Caenorhabditis elegans | CELE_ZC53.6 | Protein ZC53.6 |
Drosophila melanogaster | Dmel_CG42803 | grappa |
Echinococcus granulosus | EgrG_000184700 | histone h3 methyltransferase |
Echinococcus multilocularis | EmuJ_000184700 | histone h3 methyltransferase |
Homo sapiens | ENSG00000104885 | DOT1-like histone H3K79 methyltransferase |
Loa Loa (eye worm) | LOAG_06328 | hypothetical protein |
Mus musculus | ENSMUSG00000061589 | DOT1-like, histone H3 methyltransferase (S. cerevisiae) |
Saccharomyces cerevisiae | YDR440W | Dot1p |
Schistosoma japonicum | Sjp_0030800 | ko:K05302 histone-lysine N-methyltransferase [EC2.1.1.43], putative |
Schistosoma mansoni | Smp_165000 | histone J3 methyltransferase |
Schmidtea mediterranea | mk4.000380.15 | Histone-lysine N-methyltransferase, H3 lysine-79 specific |
Schmidtea mediterranea | mk4.000380.16 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y39G10AR.18 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y39G10AR.18 | Caenorhabditis elegans | slow growth | wormbase |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | DOT1-like histone H3K79 methyltransferase | Compounds | References |