Detailed view for TVAG_429960

Basic information

TDR Targets ID: 897215
Trichomonas vaginalis, estradiol 17 beta-dehydrogenase, putative
Source Database / ID: 

pI: 9.483 | Length (AA): 304 | MW (Da): 34550 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00106   short chain dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132068)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0293034   hypothetical protein
Dictyostelium discoideum DDB_G0286197   hypothetical protein
Drosophila melanogaster Dmel_CG6012   CG6012 gene product from transcript CG6012-RA
Entamoeba histolytica EHI_118210   estradiol 17-beta-dehydrogenase, putative
Leishmania braziliensis LbrM.33.1860   hypothetical protein, conserved
Leishmania donovani LdBPK_331690.1   3-ketoacyl-CoA reductase, putative
Leishmania infantum LinJ.33.1690   hypothetical protein, conserved
Leishmania major LmjF.33.1590   hypothetical protein, conserved
Leishmania mexicana LmxM.32.1590   hypothetical protein, conserved
Oryza sativa 4350399   Os11g0432600
Trypanosoma brucei gambiense Tbg972.10.14760   short-chain dehydrogenase, putative
Trypanosoma brucei Tb927.10.12240   3-ketoacyl-CoA reductase, putative
Trypanosoma congolense TcIL3000_10_10470   3-ketoacyl-CoA reductase, putative
Trypanosoma cruzi TcCLB.509213.100   3-ketoacyl-CoA reductase, putative
Trypanosoma cruzi TcCLB.510257.60   3-ketoacyl-CoA reductase, putative
Trichomonas vaginalis TVAG_041000   short-chain dehydrogenase, putative
Trichomonas vaginalis TVAG_174570   steroid dehydrogenase, putative
Trichomonas vaginalis TVAG_429960   estradiol 17 beta-dehydrogenase, putative

Essentiality

TVAG_429960 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.12240 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.12240 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.12240 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.12240 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0064 0.3508 0.5
0.0165 1 0.5
0.0066 0.3586 0.5
0.0004 0.5 0.5
0.0118 1 1
0.0222 0.5 0.5
0.0132 0.3658 1
0.0087 0.5 0.5
0.0068 0.2585 1
0.007 1 0.5
0.0408 0.5144 1
0.0004 0.5 0.5
0.0408 0.5144 1
0.0106 0.5 0.5
0.0005 0.5 0.5
0.0056 0.875 1
0.0057 0.284 0.674
0.0123 0.5 0.5
0.0021 0.5 0.5
0.0071 0.3141 0.5
0.007 0.2916 1
0.0039 1 0.5
0.0035 1 0.5
0.0009 0.5 0.5
0.007 1 0.5
0.0009 1 0.5
0.0402 1 1
0.0102 0.7451 0.5
0.0085 1 1
0.0073 0.4546 1
0.0088 1 0.5
0.0089 0.5 0.5
0.0157 0.5 0.5
0.008 0.5 0.5
0.0032 1 1
0.0056 1 0.5
0.0053 1 1
0.0119 0.2746 1
0.0004 0.5 0.5
0.0089 0.5 0.5
0.0012 0.5 0.5
0.016 0.577 1
0.0408 0.5144 1
0.0088 0.6544 0.5
0.0013 1 0.5
0.016 0.577 1
0.0076 1 0.5
0.0005 0.5 0.5
0.0058 0.3931 0.5
0.0004 0.5 0.5
0.0114 1 0.5
0.0058 1 1
0.0046 0.3082 0
0.0009 0.5 0.5
0.0009 0.5 0.5
0.0106 1 0.5
0.0013 0.5 0.5
0.0027 0.5 0.5
0.0016 0.5 0.5
0.0004 0.5 0.5
0.0082 1 0.5
0.0073 0.3811 1
0.0026 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0073 0.3811 1
0.011 0.3568 1
0.0012 0.5 0.5
0.0021 0.3321 0.5
0.0093 0.5 0.5
0.007 1 0.5
0.0021 0.3321 0.5
0.0068 1 1
0.0009 0.5 0.5
0.0196 0.8679 1
0.0009 0.5 0.5
0.0053 1 1
0.0171 0.4063 0.5
0.0009 0.5 0.5
0.0097 0.4304 0.5
0.0131 0.5 0.5
0.0108 0.5 0.5
0.0084 0.4283 0.4283
0.0045 1 0.5
0.0019 0.4322 1
0.0113 1 1
0.0097 1 1
0.0073 0.3141 1
0.0162 1 1
0.0009 0.7374 0.5
0.004 0.5 0.5
0.0073 0.2873 1
0.0196 0.8679 1
0.0009 0.5 0.5
0.0171 0.4063 0.5
0.0106 1 1
0.0106 0.2872 0.2872
0.0218 0.5 0.5
0.007 0.2916 1
0.0068 1 0.5
0.0067 0.3468 1
0.0114 1 0.5
0.007 0.2916 1
0.0196 0.8679 1
0.0009 0.5 0.5
0.0027 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_429960 (Trichomonas vaginalis), estradiol 17 beta-dehydrogenase, putative
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