pI: 9.2662 |
Length (AA): 341 |
MW (Da): 36821 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
21 | 336 | 3hmj (A) | 640 | 991 | 17.00 | 0 | 1 | 0.987586 | 0.53 |
46 | 75 | 4iuy (A) | 2 | 30 | 52.00 | 0 | 0.85 | 0.508877 | 0.92 |
48 | 245 | 1zk4 (A) | 1 | 195 | 31.00 | 0 | 1 | 0.982845 | -0.46 |
50 | 274 | 3rkr (A) | 3 | 235 | 35.00 | 0 | 1 | 1.15002 | -0.84 |
51 | 240 | 3ucx (A) | 5 | 189 | 31.00 | 0 | 1 | 0.903785 | -0.96 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Dormant phase. | murphy |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase. | hasan |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
Ortholog group members (OG5_127561)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G50770 | hydroxysteroid dehydrogenase 6 |
Brugia malayi | Bm1_37150 | oxidoreductase, short chain dehydrogenase/reductase family protein |
Brugia malayi | Bm1_34450 | oxidoreductase, short chain dehydrogenase/reductase family protein |
Candida albicans | CaO19_6502 | hypothetical protein |
Candida albicans | CaO19.13855 | potential short chain dehydrogenase |
Candida albicans | CaO19.6502 | potential short chain dehydrogenase |
Caenorhabditis elegans | CELE_T05F1.10 | Protein DHS-4 |
Caenorhabditis elegans | CELE_T11F9.11 | Protein DHS-19 |
Caenorhabditis elegans | CELE_T02E1.5 | Protein DHS-3, isoform C |
Drosophila melanogaster | Dmel_CG9265 | CG9265 gene product from transcript CG9265-RB |
Drosophila melanogaster | Dmel_CG15629 | CG15629 gene product from transcript CG15629-RA |
Drosophila melanogaster | Dmel_CG2254 | CG2254 gene product from transcript CG2254-RA |
Echinococcus granulosus | EgrG_000992500 | epidermal retinal dehydrogenase 2 |
Echinococcus multilocularis | EmuJ_000992500 | epidermal retinal dehydrogenase 2 |
Homo sapiens | ENSG00000170786 | short chain dehydrogenase/reductase family 16C, member 5 |
Loa Loa (eye worm) | LOAG_02402 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04354 | hypothetical protein |
Mus musculus | ENSMUSG00000071019 | short chain dehydrogenase/reductase family 16C, member 6 |
Mus musculus | ENSMUSG00000028236 | short chain dehydrogenase/reductase family 16C, member 5 |
Mycobacterium tuberculosis | Rv0547c | Possible oxidoreductase |
Mycobacterium tuberculosis | Rv1543 | Possible fatty acyl-CoA reductase |
Mycobacterium ulcerans | MUL_4828 | short-chain type dehydrogenase/reductase |
Mycobacterium ulcerans | MUL_0647 | short chain dehydrogenase |
Saccharomyces cerevisiae | YDL114W | short-chain dehydrogenase/reductase |
Schistosoma japonicum | Sjp_0004470 | Epidermal retinal dehydrogenase 2, putative |
Schistosoma mansoni | Smp_000190 | oxidoreductase short chain dehydrogenase/reductase family |
Schmidtea mediterranea | mk4.008944.00 | |
Schmidtea mediterranea | mk4.018229.00 | Short-chain dehydrogenase/reductase 3 |
Schmidtea mediterranea | mk4.000498.04 | |
Schmidtea mediterranea | mk4.007890.00 | Retinol dehydrogenase 10 |
Trypanosoma brucei gambiense | Tbg972.10.8390 | short-chain dehydrogenase, putative |
Trypanosoma brucei | Tb927.10.6870 | short-chain dehydrogenase, putative |
Trypanosoma congolense | TcIL3000_10_5900 | short-chain dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.510187.74 | short-chain dehydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1571 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.10.6870 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.6870 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.6870 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.6870 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T02E1.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.4
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Macaca mulatta | Hydroxysteroid 11-beta dehydrogenase 1 | 140 aa | 33.3% | 144 aa | Compounds | References |
9 literature references were collected for this gene.