Detailed information for compound 1008651

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 351.439 | Formula: C22H25NO3
  • H donors: 0 H acceptors: 1 LogP: 4.1 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1CCc2c3[C@H]1Cc1cccc(c1c3cc(c2)OC)OC(=O)C
  • InChi: 1S/C22H25NO3/c1-4-9-23-10-8-16-11-17(25-3)13-18-21(16)19(23)12-15-6-5-7-20(22(15)18)26-14(2)24/h5-7,11,13,19H,4,8-10,12H2,1-3H3/t19-/m1/s1
  • InChiKey: ICIICPHBNXIOKJ-LJQANCHMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine D1 receptor Starlite/ChEMBL References
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D1 receptor   446 aa 373 aa 25.5 %
Schistosoma mansoni amine GPCR Dopamine D2 receptor   444 aa 424 aa 32.1 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Dopamine D2 receptor   444 aa 386 aa 19.7 %
Onchocerca volvulus Dopamine D2 receptor   444 aa 418 aa 23.0 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Schistosoma mansoni biogenic amine (5HT) receptor Dopamine D1 receptor   446 aa 394 aa 29.9 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Dopamine D2 receptor   444 aa 476 aa 24.2 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Loa Loa (eye worm) hypothetical protein Dopamine D1 receptor   446 aa 370 aa 24.9 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Onchocerca volvulus Dopamine D1 receptor   446 aa 357 aa 21.0 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D1 receptor   446 aa 366 aa 35.2 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Dopamine D1 receptor   446 aa 407 aa 33.7 %
Echinococcus granulosus g protein coupled receptor Dopamine D2 receptor   444 aa 457 aa 21.0 %
Echinococcus multilocularis g protein coupled receptor Dopamine D2 receptor   444 aa 465 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica tubulin gamma chain 0.0648 0.5514 0.5498
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0091 0.0054
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0105 0.0105
Trichomonas vaginalis tubulin epsilon chain, putative 0.0897 0.7681 0.7673
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Trypanosoma brucei tubulin delta chain 0.0281 0.2325 0.2297
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0105 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0265 0.0265
Giardia lamblia Gamma tubulin 0.0648 0.5514 0.5498
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0105 0.0344
Trichomonas vaginalis tubulin alpha chain, putative 0.0366 0.3067 0.3041
Plasmodium vivax tubulin alpha chain, putative 0.0897 0.7681 0.7673
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0307 0.0307
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0431 0.0431
Plasmodium vivax delta tubulin, putative 0.0281 0.2325 0.2297
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.004 0.0227 0.0832
Echinococcus granulosus tubulin gamma 1 chain 0.0648 0.5514 0.5514
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Loa Loa (eye worm) tubulin alpha 2 0.0249 0.2044 0.2044
Leishmania major delta tubulin, putative 0.0281 0.2325 0.2297
Echinococcus granulosus tubulin alpha 1C chain 0.0897 0.7681 0.7681
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.004 0.0227 0.0832
Loa Loa (eye worm) BEN-1 protein 0.1163 1 1
Brugia malayi Peroxidasin 0.0026 0.0105 0.0105
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0789 0.0755
Loa Loa (eye worm) beta-tubulin 0.1163 1 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0431 0.0431
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0431 0.0431
Plasmodium falciparum alpha tubulin 2 0.0897 0.7681 0.7673
Leishmania major epsilon tubulin, putative 0.0648 0.5514 0.5498
Trypanosoma brucei epsilon tubulin 0.0648 0.5514 0.5498
Echinococcus granulosus GPCR family 2 0.0016 0.0013 0.0013
Trichomonas vaginalis tubulin gamma chain, putative 0.1163 1 1
Loa Loa (eye worm) tubulin gamma chain 0.0648 0.5514 0.5514
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0194 0.0194
Echinococcus granulosus tubulin alpha chain 0.0897 0.7681 0.7681
Echinococcus multilocularis Tubulin beta 2C chain 0.1163 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0227 0.0227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.000000035137 0.000000035137
Brugia malayi intermediate filament protein 0.0027 0.011 0.011
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0037 0.0037
Echinococcus multilocularis tubulin subunit TubB 0.0897 0.7681 0.7681
Brugia malayi hypothetical protein 0.0025 0.0091 0.0091
Echinococcus multilocularis tubulin epsilon chain 0.0648 0.5514 0.5514
Schistosoma mansoni peroxidasin 0.0026 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0003
Trypanosoma brucei zeta tubulin 0.0281 0.2325 0.2297
Schistosoma mansoni tubulin subunit beta 0.1163 1 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0091
Trypanosoma brucei beta tubulin 0.0648 0.5514 0.5498
Loa Loa (eye worm) tubulin alpha chain 0.0897 0.7681 0.7681
Leishmania major beta tubulin 0.1163 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0091 0.0054
Leishmania major beta tubulin 0.1163 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0307 0.0307
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.004 0.0227 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.0281 0.2325 0.2297
Echinococcus multilocularis tubulin gamma 1 chain 0.0648 0.5514 0.5514
Schistosoma mansoni tubulin subunit beta 0.1163 1 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.004 0.0227 0.0832
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.004 0.0227 0.0832
Echinococcus granulosus tubulin alpha chain 0.0897 0.7681 0.7681
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0431 0.0431
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0105 0.0105
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Loa Loa (eye worm) hypothetical protein 0.0063 0.0424 0.0424
Trypanosoma brucei epsilon tubulin 0.0648 0.5514 0.5498
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Echinococcus granulosus Tubulin beta 2C chain 0.1163 1 1
Plasmodium vivax tubulin gamma chain, putative 0.0648 0.5514 0.5498
Echinococcus multilocularis tubulin alpha chain 0.0897 0.7681 0.7681
Schistosoma mansoni tubulin subunit beta 0.1163 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.011 0.011
Toxoplasma gondii beta tubulin 0.1163 1 1
Trypanosoma cruzi tubulin gamma chain 0.0648 0.5514 0.5498
Brugia malayi Tubulin alpha chain 0.0281 0.2325 0.2325
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0431 0.0431
Echinococcus multilocularis tubulin alpha chain 0.0897 0.7681 0.7681
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0431 0.0431
Echinococcus granulosus tubulin subunit beta 0.1163 1 1
Echinococcus granulosus tubulin epsilon chain 0.0648 0.5514 0.5514
Trypanosoma brucei epsilon tubulin 0.0648 0.5514 0.5498
Leishmania major beta tubulin 0.1163 1 1
Brugia malayi Tubulin beta chain 0.0366 0.3067 0.3067
Loa Loa (eye worm) cytochrome P450 0.004 0.0227 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0789 0.0755
Trypanosoma brucei alpha tubulin 0.0897 0.7681 0.7673
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0194 0.0194
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Echinococcus multilocularis tubulin delta chain 0.0281 0.2325 0.2325
Trichomonas vaginalis tubulin beta chain, putative 0.1163 1 1
Giardia lamblia Alpha-tubulin 0.0897 0.7681 0.7673
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0013
Onchocerca volvulus 0.0026 0.0105 0.0344
Schistosoma mansoni hypothetical protein 0.0036 0.0194 0.0194
Loa Loa (eye worm) alpha-tubulin 0.0897 0.7681 0.7681
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0307 0.0307
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0648 0.5514 0.5498
Echinococcus multilocularis tubulin alpha chain 0.0897 0.7681 0.7681
Leishmania major alpha tubulin 0.0897 0.7681 0.7673
Trichomonas vaginalis tubulin beta chain, putative 0.0897 0.7681 0.7673
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Echinococcus granulosus tubulin alpha 3 chain 0.0897 0.7681 0.7681
Loa Loa (eye worm) hypothetical protein 0.0615 0.5234 0.5234
Loa Loa (eye worm) hypothetical protein 0.053 0.4492 0.4492
Echinococcus multilocularis musashi 0.0027 0.011 0.011
Trypanosoma brucei cytochrome P450, putative 0.004 0.0227 0.0191
Trypanosoma brucei tubulin gamma chain 0.0648 0.5514 0.5498
Echinococcus granulosus tubulin beta 4A class IVa 0.1163 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0013 0.0013
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0358 0.2998 0.2998
Trichomonas vaginalis tubulin, putative 0.1163 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0897 0.7681 0.7681
Echinococcus granulosus peroxisome assembly protein 26 0.0897 0.7681 0.7681
Trypanosoma brucei alpha tubulin 0.0897 0.7681 0.7673
Loa Loa (eye worm) hypothetical protein 0.015 0.1182 0.1182
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.004 0.0227 0.0832
Schistosoma mansoni tubulin subunit gamma 0.0648 0.5514 0.5514
Echinococcus granulosus peroxidasin 0.0026 0.0105 0.0105
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0091 0.0054
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0615 0.5234 0.5234
Entamoeba histolytica hypothetical protein 0.0105 0.0789 0.0755
Echinococcus multilocularis hypothetical protein 0.0897 0.7681 0.7681
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0036 0.0194 0.0158
Leishmania major alpha tubulin 0.0897 0.7681 0.7673
Leishmania major beta tubulin 0.1163 1 1
Schistosoma mansoni tubulin subunit alpha 0.0897 0.7681 0.7681
Leishmania major beta tubulin 0.1163 1 1
Echinococcus granulosus tubulin subunit TubB 0.0897 0.7681 0.7681
Echinococcus granulosus Tubulin beta 2C chain 0.1163 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.0648 0.5514 0.5498
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.004 0.0227 0.0191
Leishmania major beta tubulin 0.1163 1 1
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0227 0.0191
Echinococcus granulosus intermediate filament protein 0.0027 0.011 0.011
Brugia malayi cytochrome P450 0.004 0.0227 0.0227
Onchocerca volvulus 0.0366 0.3067 1
Brugia malayi Uncoordinated protein 44 0.0014 0.000000035137 0.000000035137
Loa Loa (eye worm) hypothetical protein 0.0234 0.1913 0.1913
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0105 0.0105
Leishmania major beta tubulin 0.1163 1 1
Echinococcus granulosus tubulin alpha chain 0.0897 0.7681 0.7681
Brugia malayi Blistered cuticle protein 3 0.0026 0.0105 0.0105
Entamoeba histolytica hypothetical protein 0.0036 0.0194 0.0158
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0615 0.5234 0.5216
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.004 0.0227 0.0832
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0154 0.1214 0.1214
Echinococcus multilocularis tubulin subunit beta 0.1163 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.1163 1 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.004 0.0227 0.0832
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0265 0.0265
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0002 0.0002
Giardia lamblia Alpha-tubulin 0.0897 0.7681 0.7673
Leishmania major alpha tubulin 0.0897 0.7681 0.7673
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0905 0.0905
Toxoplasma gondii beta-1 tubulin, putative 0.1163 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0897 0.7681 0.7681
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0789 0.0755
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Leishmania major beta tubulin 0.1163 1 1
Loa Loa (eye worm) BEN-1 protein 0.1163 1 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.004 0.0227 0.0832
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.004 0.0227 0.0832
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0091 0.0054
Trichomonas vaginalis tubulin, putative 0.0281 0.2325 0.2297
Loa Loa (eye worm) tubulin alpha-3 chain 0.053 0.4492 0.4492
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0091 0.0054
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.004 0.0227 0.0832
Giardia lamblia Epsilon tubulin 0.0281 0.2325 0.2297
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.004 0.0227 0.0832
Schistosoma mansoni lamin 0.0027 0.011 0.011
Brugia malayi RNA binding protein 0.0064 0.0431 0.0431
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0105 0.0344
Brugia malayi tubulin alpha chain - mouse 0.0897 0.7681 0.7681
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.011 0.011
Echinococcus granulosus lamin dm0 0.0027 0.011 0.011
Trypanosoma brucei beta tubulin 0.1163 1 1
Giardia lamblia Beta tubulin 0.1163 1 1
Treponema pallidum cell division protein FtsZ 0.0281 0.2325 1
Entamoeba histolytica tubulin family protein 0.1163 1 1
Onchocerca volvulus 0.0026 0.0105 0.0344
Leishmania major alpha tubulin 0.0897 0.7681 0.7673
Leishmania major alpha tubulin 0.0897 0.7681 0.7673
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0227 0.0227
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.004 0.0227 0.0832
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0013
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0105 0.0105
Trichomonas vaginalis tubulin gamma chain, putative 0.0648 0.5514 0.5498
Loa Loa (eye worm) tubulin beta-2A chain 0.1163 1 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0648 0.5514 0.5498
Echinococcus multilocularis tubulin alpha 1C chain 0.0897 0.7681 0.7681
Giardia lamblia NADPH oxidoreductase, putative 0.0419 0.3527 0.3503
Echinococcus multilocularis lamin 0.0027 0.011 0.011
Trichomonas vaginalis tubulin, putative 0.0366 0.3067 0.3041
Leishmania major hypothetical protein, conserved 0.0025 0.0091 0.0054
Brugia malayi beta-tubulin, identical 0.1163 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0105 0.0105
Brugia malayi tubulin alpha-2 chain 0.0897 0.7681 0.7681
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0307 0.0307
Brugia malayi Protein kinase domain containing protein 0.0014 0.000000035137 0.000000035137
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0013
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.004 0.0227 0.0832
Leishmania major cytochrome p450-like protein 0.004 0.0227 0.0191
Echinococcus granulosus alpha tubulin 0.0897 0.7681 0.7681
Leishmania major cytochrome p450-like protein 0.004 0.0227 0.0191
Trypanosoma brucei beta tubulin 0.1163 1 1
Echinococcus granulosus lamin 0.0027 0.011 0.011
Giardia lamblia NADPH oxidoreductase, putative 0.0419 0.3527 0.3503
Echinococcus multilocularis tubulin alpha chain 0.0897 0.7681 0.7681
Echinococcus granulosus tar DNA binding protein 0.0064 0.0431 0.0431
Giardia lamblia NADPH oxidoreductase, putative 0.0419 0.3527 0.3503
Echinococcus multilocularis muscleblind protein 1 0.015 0.1182 0.1182
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Echinococcus granulosus tubulin alpha 3 chain 0.0897 0.7681 0.7681
Toxoplasma gondii alpha tubulin TUBA1 0.0897 0.7681 0.7673
Echinococcus multilocularis tubulin alpha chain 0.0897 0.7681 0.7681
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Schistosoma mansoni ap endonuclease 0.0018 0.0037 0.0037
Trypanosoma cruzi beta tubulin, putative 0.1163 1 1
Schistosoma mansoni tubulin subunit beta 0.0281 0.2325 0.2325
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Loa Loa (eye worm) tubulin alpha-2 chain 0.0897 0.7681 0.7681
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.004 0.0227 0.0832
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0105 0.0105
Schistosoma mansoni tubulin subunit beta 0.1163 1 1
Brugia malayi hypothetical protein 0.0036 0.0194 0.0194
Loa Loa (eye worm) tubulin beta chain 0.0281 0.2325 0.2325
Brugia malayi Cytochrome P450 family protein 0.004 0.0227 0.0227
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.004 0.0227 0.0832
Loa Loa (eye worm) RNA binding protein 0.0064 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Trichomonas vaginalis tubulin gamma chain, putative 0.0648 0.5514 0.5498
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0091 0.0054
Loa Loa (eye worm) tubulin alpha 2 0.0615 0.5234 0.5234
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0366 0.3067 0.3041
Leishmania major beta tubulin 0.1163 1 1
Leishmania major alpha tubulin 0.0897 0.7681 0.7673
Loa Loa (eye worm) hypothetical protein 0.0027 0.011 0.011
Trichomonas vaginalis tubulin epsilon chain, putative 0.1163 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Loa Loa (eye worm) hypothetical protein 0.0034 0.0171 0.0171
Trichomonas vaginalis tubulin alpha chain, putative 0.0648 0.5514 0.5498
Leishmania major gamma-tubulin 0.0648 0.5514 0.5498
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0265 0.0265
Trypanosoma cruzi zeta tubulin, putative 0.0281 0.2325 0.2297
Plasmodium falciparum tubulin delta chain, putative 0.0281 0.2325 0.2297
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.004 0.0227 0.0832
Echinococcus multilocularis beta tubulin 0.1163 1 1
Brugia malayi Tubulin beta chain 0.0281 0.2325 0.2325
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0037 0.0037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0037 0.0037
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0091 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0431 0.0431
Onchocerca volvulus 0.0027 0.011 0.0358
Brugia malayi Muscleblind-like protein 0.015 0.1182 0.1182
Trichomonas vaginalis tubulin alpha chain, putative 0.0366 0.3067 0.3041
Leishmania major alpha tubulin 0.0897 0.7681 0.7673
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0431 0.0431
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Leishmania major beta tubulin 0.1163 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.004 0.0227 0.0832
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0105 0.0789 0.0755
Trypanosoma brucei beta tubulin 0.1163 1 1
Onchocerca volvulus Peroxidase homolog 0.0026 0.0105 0.0344
Trypanosoma cruzi tubulin delta chain 0.0281 0.2325 0.2297
Echinococcus granulosus transient receptor potential cation channel 0.0157 0.1241 0.1241
Mycobacterium leprae cell division protein FtsZ 0.0281 0.2325 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0789 0.0755
Brugia malayi Tubulin alpha-2 chain 0.0897 0.7681 0.7681
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.004 0.0227 0.0832
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.004 0.0227 0.0832
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.004 0.0227 0.0832
Trypanosoma brucei beta tubulin 0.1163 1 1
Brugia malayi alpha-tubulin 0.0897 0.7681 0.7681
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Trichomonas vaginalis tubulin beta chain, putative 0.0897 0.7681 0.7673
Loa Loa (eye worm) hypothetical protein 0.0897 0.7681 0.7681
Echinococcus multilocularis 0.004 0.0227 0.0227
Echinococcus multilocularis transient receptor potential cation channel 0.0157 0.1245 0.1245
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0105 0.0105
Echinococcus multilocularis tubulin alpha 0.0648 0.5514 0.5514
Echinococcus granulosus nuclear factor of activated T cells 5 0.0358 0.2998 0.2998
Echinococcus granulosus tubulin delta chain 0.0281 0.2325 0.2325
Echinococcus multilocularis ankyrin repeat protein 0.0154 0.1214 0.1214
Echinococcus granulosus ankyrin repeat protein 0.0154 0.1214 0.1214
Echinococcus multilocularis Tubulin beta 2C chain 0.1163 1 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.004 0.0227 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0265 0.0265
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.004 0.0227 0.0191
Trichomonas vaginalis tubulin beta chain, putative 0.0897 0.7681 0.7673
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0789 0.0755
Schistosoma mansoni cytochrome P450 0.004 0.0227 0.0227
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.004 0.0227 0.0832
Brugia malayi hypothetical protein 0.0016 0.0015 0.0015
Echinococcus granulosus Tubulin alpha 1 chain 0.0897 0.7681 0.7681
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0105 0.0789 0.0755
Echinococcus multilocularis Tubulin beta 2C chain 0.1163 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0013 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.004 0.0227 0.0832
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0002 0.0002
Brugia malayi Cell division protein ftsZ 0.0281 0.2325 0.2325
Giardia lamblia Beta tubulin 0.1163 1 1
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0297 0.246 0.246
Trichomonas vaginalis tubulin beta chain, putative 0.0897 0.7681 0.7673
Echinococcus multilocularis Tubulin beta 2C chain 0.1163 1 1
Schistosoma mansoni lamin 0.0027 0.011 0.011
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0171 0.0171
Leishmania major alpha tubulin 0.0897 0.7681 0.7673
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0105 0.0789 0.0755
Toxoplasma gondii cytochrome p450 superfamily protein 0.004 0.0227 0.0191
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0281 0.2325 0.2297
Leishmania major beta tubulin 0.1163 1 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1163 1 1
Leishmania major zeta tubulin, putative 0.0281 0.2325 0.2297
Trichomonas vaginalis conserved hypothetical protein 0.0315 0.2615 0.2588
Echinococcus granulosus tubulin alpha 1C chain 0.0897 0.7681 0.7681
Echinococcus multilocularis lamin dm0 0.0027 0.011 0.011
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0265 0.0265
Entamoeba histolytica tubulin family protein 0.1163 1 1
Leishmania major beta tubulin 0.1163 1 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.004 0.0227 0.0832
Echinococcus multilocularis beta tubulin 0.1163 1 1
Schistosoma mansoni alpha tubulin 0.0897 0.7681 0.7681
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Leishmania major beta tubulin 0.1163 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0194 0.0158
Leishmania major alpha tubulin 0.0897 0.7681 0.7673
Leishmania major beta tubulin 0.1163 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Loa Loa (eye worm) alpha-tubulin 0.0897 0.7681 0.7681
Leishmania major cytochrome p450-like protein 0.004 0.0227 0.0191
Plasmodium vivax tubulin epsilon chain, putative 0.0648 0.5514 0.5498
Brugia malayi Death domain containing protein 0.0014 0.000000035137 0.000000035137
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0013
Brugia malayi Cytochrome P450 family protein 0.004 0.0227 0.0227
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0265 0.0265
Plasmodium falciparum tubulin beta chain 0.1163 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Echinococcus multilocularis Tubulin alpha 1 chain 0.0897 0.7681 0.7681
Leishmania major beta tubulin 0.1163 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0105 0.0344
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.004 0.0227 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Plasmodium vivax tubulin beta chain, putative 0.1163 1 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.004 0.0227 0.0191
Onchocerca volvulus 0.0026 0.0105 0.0344
Schistosoma mansoni ap endonuclease 0.0018 0.0037 0.0037
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0108 0.0819 0.0819
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0105 0.0789 0.0755
Echinococcus granulosus Ankyrin 0.0014 0.0003 0.0003
Echinococcus granulosus tubulin alpha 0.0648 0.5514 0.5514
Trichomonas vaginalis tubulin epsilon chain, putative 0.0281 0.2325 0.2297
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.000000035137 0.000000035137
Trypanosoma cruzi cytochrome p450-like protein, putative 0.004 0.0227 0.0191
Schistosoma mansoni tubulin subunit epsilon 0.0648 0.5514 0.5514
Plasmodium falciparum tubulin gamma chain 0.0648 0.5514 0.5498
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.004 0.0227 0.0832
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.000000035137 0.000000035137
Trichomonas vaginalis conserved hypothetical protein 0.0281 0.2325 0.2297
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Schistosoma mansoni tubulin subunit delta 0.0281 0.2325 0.2325
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.004 0.0227 0.0832
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.004 0.0227 0.0832
Echinococcus granulosus tubulin alpha chain 0.0897 0.7681 0.7681
Brugia malayi Tubulin alpha chain 0.0897 0.7681 0.7681
Schistosoma mansoni tubulin subunit alpha 0.0897 0.7681 0.7681
Trypanosoma cruzi epsilon tubulin, putative 0.0648 0.5514 0.5498
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0281 0.2325 0.2297
Echinococcus granulosus Tubulin alpha 1 chain 0.0897 0.7681 0.7681
Leishmania major alpha tubulin 0.0897 0.7681 0.7673
Echinococcus multilocularis muscleblind protein 0.015 0.1182 0.1182
Mycobacterium tuberculosis Cell division protein FtsZ 0.0281 0.2325 1
Leishmania major alpha tubulin 0.0897 0.7681 0.7673
Echinococcus granulosus Tubulin beta 2C chain 0.1163 1 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0227 0.0832
Brugia malayi Tubulin alpha-2 chain 0.0897 0.7681 0.7681
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0013 0.0013
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0281 0.2325 1
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0789 0.0755
Brugia malayi MH2 domain containing protein 0.0118 0.0905 0.0905
Trypanosoma brucei alpha tubulin, putative 0.0366 0.3067 0.3041
Brugia malayi hypothetical protein 0.0026 0.0105 0.0105
Trichomonas vaginalis tubulin beta chain, putative 0.0897 0.7681 0.7673
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0105 0.0344
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.015 0.1182 0.1182
Leishmania major beta tubulin 0.1163 1 1
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0419 0.3527 0.3503
Schistosoma mansoni alpha tubulin 0.0897 0.7681 0.7681
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0419 0.3527 0.3503
Trichomonas vaginalis tubulin gamma chain, putative 0.0281 0.2325 0.2297
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.004 0.0227 0.0832
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0419 0.3527 0.3503
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0013 0.0013
Schistosoma mansoni tubulin subunit alpha 0.0897 0.7681 0.7681
Echinococcus granulosus tubulin alpha chain 0.0897 0.7681 0.7681
Schistosoma mansoni tubulin subunit alpha 0.0281 0.2325 0.2325
Entamoeba histolytica tubulin alpha-1 chain 0.0897 0.7681 0.7673
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.004 0.0227 0.0832
Echinococcus multilocularis Tubulin alpha 1 chain 0.0897 0.7681 0.7681
Schistosoma mansoni alpha tubulin 0.0897 0.7681 0.7681
Trichomonas vaginalis tubulin beta chain, putative 0.0897 0.7681 0.7673
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.004 0.0227 0.0832
Trypanosoma brucei alpha tubulin 0.0897 0.7681 0.7673
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0194 0.0194
Schistosoma mansoni tubulin subunit beta 0.1163 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0366 0.3067 0.3041
Echinococcus multilocularis Ankyrin 0.0014 0.0003 0.0003
Onchocerca volvulus 0.0027 0.011 0.0358
Toxoplasma gondii beta-tubulin, putative 0.1163 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Toxoplasma gondii alpha-tubulin I, putative 0.0897 0.7681 0.7673
Echinococcus granulosus tubulin beta 1 chain 0.1163 1 1
Leishmania major beta tubulin 0.1163 1 1
Echinococcus granulosus beta tubulin 0.1163 1 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.004 0.0227 0.0832
Trichomonas vaginalis tubulin epsilon chain, putative 0.1163 1 1
Echinococcus multilocularis tubulin beta 1 chain 0.1163 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Loa Loa (eye worm) tubulin beta-1 chain 0.1163 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0789 0.0755
Brugia malayi Tubulin gamma chain 0.0648 0.5514 0.5514
Trypanosoma cruzi tubulin delta chain 0.0281 0.2325 0.2297
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.004 0.0227 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Trypanosoma brucei alpha tubulin 0.0897 0.7681 0.7673
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0105 0.0105
Schistosoma mansoni intermediate filament proteins 0.0027 0.011 0.011
Echinococcus multilocularis peroxisome assembly protein 26 0.0897 0.7681 0.7681
Trypanosoma brucei zeta tubulin, putative 0.0281 0.2325 0.2297
Loa Loa (eye worm) tubulin beta chain 0.1163 1 1
Loa Loa (eye worm) tubulin beta-4 chain 0.1163 1 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.004 0.0227 0.0832
Brugia malayi TAR-binding protein 0.0064 0.0431 0.0431
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0265 0.0265
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0227 0.0227
Loa Loa (eye worm) intermediate filament protein 0.0027 0.011 0.011
Leishmania major beta tubulin 0.1163 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Echinococcus multilocularis Tubulin beta 2C chain 0.1163 1 1
Schistosoma mansoni hypothetical protein 0.004 0.0227 0.0227
Echinococcus multilocularis GPCR, family 2 0.0016 0.0013 0.0013
Echinococcus multilocularis peroxidasin 0.0026 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0227 0.0191
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0265 0.0265
Plasmodium falciparum alpha tubulin 1 0.0897 0.7681 0.7673
Entamoeba histolytica tubulin alpha chain, putative 0.0897 0.7681 0.7673
Echinococcus granulosus beta tubulin 0.1163 1 1
Schistosoma mansoni peroxidasin 0.0026 0.0105 0.0105
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0037 0.0037
Entamoeba histolytica hypothetical protein 0.0036 0.0194 0.0158
Trichomonas vaginalis tubulin epsilon chain, putative 0.0897 0.7681 0.7673
Loa Loa (eye worm) tubulin alpha chain 0.0897 0.7681 0.7681
Brugia malayi Cytochrome P450 family protein 0.004 0.0227 0.0227
Echinococcus granulosus Tubulin beta 2C chain 0.1163 1 1
Mycobacterium ulcerans cell division protein FtsZ 0.0281 0.2325 1
Trypanosoma cruzi zeta tubulin, putative 0.0281 0.2325 0.2297
Echinococcus multilocularis tubulin alpha 3 chain 0.0897 0.7681 0.7681
Echinococcus granulosus Tubulin alpha 1 chain 0.0897 0.7681 0.7681
Echinococcus granulosus cytochrome P450 2K1 0.004 0.0227 0.0227
Plasmodium vivax tubulin alpha chain, putative 0.0897 0.7681 0.7673
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0789 0.0755
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.004 0.0227 0.0832
Echinococcus multilocularis tubulin alpha 1C chain 0.0897 0.7681 0.7681
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0897 0.7681 0.7673
Trichomonas vaginalis tubulin, putative 0.0366 0.3067 0.3041
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.004 0.0227 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0789 0.0755
Onchocerca volvulus Peroxidase homolog 0.0026 0.0105 0.0344
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.004 0.0227 0.0832
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0105 0.0789 0.0755
Loa Loa (eye worm) tubulin alpha 2 0.0615 0.5234 0.5234
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0281 0.2325 0.2297
Echinococcus granulosus muscleblind protein 0.015 0.1182 0.1182
Loa Loa (eye worm) hypothetical protein 0.0126 0.0971 0.0971
Giardia lamblia Beta tubulin 0.1163 1 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.004 0.0227 0.0832
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0013 0.0013
Giardia lamblia Delta tubulin 0.0281 0.2325 0.2297
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.004 0.0227 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Echinococcus granulosus Tubulin beta 2C chain 0.1163 1 1
Schistosoma mansoni tubulin subunit beta 0.1163 1 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.004 0.0227 0.0832
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0431 0.0431
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.053 0.4492 0.4472
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.3527 0.3503
Schistosoma mansoni hypothetical protein 0.0034 0.0171 0.0171
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.0789 0.0755
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Trichomonas vaginalis tubulin beta chain, putative 0.0366 0.3067 0.3041
Leishmania major alpha tubulin 0.0897 0.7681 0.7673
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Loa Loa (eye worm) CYP4Cod1 0.004 0.0227 0.0227
Trypanosoma cruzi alpha tubulin, putative 0.0897 0.7681 0.7673
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0905 0.0905
Brugia malayi Cytochrome P450 family protein 0.004 0.0227 0.0227

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 18.9 nM Displacement of [3H]nemonapride from dopamine D2 receptor in rat forebrain ChEMBL. 19058967
Ki (binding) > 10000 nM Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain ChEMBL. 19058967

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.