Detailed information for compound 1035243

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.401 | Formula: C19H22N4O7
  • H donors: 6 H acceptors: 7 LogP: 0.24 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)CC[C@H](C(=O)O)NC(=O)[C@@H](NC(=O)CNC(=O)c1cc2c([nH]1)cccc2)C
  • InChi: 1S/C19H22N4O7/c1-10(17(27)23-13(19(29)30)6-7-16(25)26)21-15(24)9-20-18(28)14-8-11-4-2-3-5-12(11)22-14/h2-5,8,10,13,22H,6-7,9H2,1H3,(H,20,28)(H,21,24)(H,23,27)(H,25,26)(H,29,30)/t10-,13+/m0/s1
  • InChiKey: PKKHJNXBYOKDRF-GXFFZTMASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0138 0.0962
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.045 0.2338
Trichomonas vaginalis maltase-glucoamylase, putative 0.0021 0.0049 0.031
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0048 0.0335
Brugia malayi Calcitonin receptor-like protein seb-1 0.0127 0.0578 0.0795
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.012 0.0989
Trypanosoma brucei trypanothione reductase 0.005 0.0195 0.0724
Giardia lamblia Grp94/Hsp90 0.0046 0.0172 0.053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0686
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0138 0.1139
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0039 0.0179
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0068 0.0282 0.4741
Schistosoma mansoni kinase 0.0051 0.0199 0.1399
Brugia malayi Hsp90 protein 0.0032 0.0106 0.0143
Leishmania major cysteine peptidase A (CPA) 0.0012 0.0005 0.0019
Echinococcus granulosus citrate lyase subunit beta protein 0.0026 0.0074 0.038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.018 0.1181
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0263 0.1843
Onchocerca volvulus 0.0027 0.0078 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0138 0.094
Mycobacterium ulcerans lipoprotein LpqF 0.0068 0.0282 0.1907
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0005 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0331 0.1215
Mycobacterium tuberculosis Conserved protein 0.0039 0.0138 0.1139
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0046 0.0311
Loa Loa (eye worm) hypothetical protein 0.0047 0.018 0.1254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0099 0.0145
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0012 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0053 0.0209 0.1461
Leishmania major cytochrome p450-like protein 0.0016 0.0026 0.0095
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0005 0.0009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0126
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0039 0.0028
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0138 0.0959
Leishmania major cathepsin L-like protease 0.0012 0.0005 0.0019
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0108 0.0482 0.3373
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0291
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0046 0.0233
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.0444 0.1652
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0515 0.4351
Brugia malayi PHD-finger family protein 0.0031 0.0099 0.0134
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0576 0.4052
Schistosoma mansoni axis inhibition protein axin 0.002 0.0046 0.0324
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0014 0.0032
Mycobacterium ulcerans hypothetical protein 0.0026 0.0074 0.0431
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0005 0.0004
Mycobacterium ulcerans hypothetical protein 0.0026 0.0074 0.0431
Trichomonas vaginalis UDP-glucose 4-epimerase, putative 0.0052 0.0205 0.1416
Brugia malayi AMP-binding enzyme family protein 0.0047 0.018 0.0245
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0049 0.031
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0138 0.0512
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0195 0.1361
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0014 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.064 0.4512
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0099 0.0438 0.3019
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0099 0.035
Loa Loa (eye worm) RGS-3 protein 0.002 0.0046 0.0311
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0539
Echinococcus granulosus heat shock protein 90 0.0042 0.0152 0.0786
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0014 0.0061
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0059 0.0239 0.0354
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0032
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.1022
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0014 0.0082
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0014 0.0016
Schistosoma mansoni hypothetical protein 0.0047 0.0177 0.1248
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0192 0.1323
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0014 0.0082
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0108 0.0482 0.1776
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.0444 0.061
Schistosoma mansoni methyl-cpg binding protein mbd 0.0012 0.0006 0.0045
Brugia malayi Thioredoxin reductase 0.005 0.0195 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.064 0.4512
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0049 0.031
Loa Loa (eye worm) hypothetical protein 0.0127 0.0578 0.4066
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0046 0.0061
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0156
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0048 0.0322
Echinococcus granulosus heat shock protein 0.0049 0.0187 0.0968
Giardia lamblia PHD finger protein 15 0.0031 0.0099 0.0254
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0172 0.1182
Toxoplasma gondii Hsp90 domain-containing protein 0.0185 0.0864 0.3197
Entamoeba histolytica UDP-glucose 4-epimerase, putative 0.0052 0.0205 0.4556
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0046 0.0067
Brugia malayi latrophilin 2 splice variant baaae 0.0087 0.0378 0.0518
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.018 0.1181
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0005 0.0034
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0118 0.0609
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.1022
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0012 0.0005 0.0001
Trypanosoma brucei heat shock protein, putative 0.0049 0.0187 0.0695
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0444 0.3107
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.004 0.0145 0.0214
Trypanosoma cruzi Heat shock protein 83, putative 0.0049 0.0187 0.0695
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0108 0.0482 0.3373
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Trypanosoma brucei heat shock protein, putative 0.0049 0.0187 0.0695
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0311
Echinococcus granulosus axis inhibition protein axin 0.002 0.0046 0.0233
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0151 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0444 0.3107
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0684
Plasmodium vivax heat shock protein 90, putative 0.0032 0.0106 0.0375
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0111 0.0907
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0099 0.0438 0.2276
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0127 0.0578 0.0795
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0176 0.0654
Brugia malayi PXA domain containing protein 0.002 0.0046 0.0061
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0195 0.0707
Mycobacterium ulcerans glutaminase 0.0296 0.142 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.012 0.0834
Schistosoma mansoni chromobox protein 0.0012 0.0005 0.0034
Loa Loa (eye worm) hypothetical protein 0.0052 0.0201 0.1405
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Schistosoma mansoni chromobox protein 0.0074 0.0313 0.2207
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0014 0.0082
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0031 0.0116
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0176 0.0654
Onchocerca volvulus 0.0014 0.0014 0.0009
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0021 0.0049 0.031
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0311
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0031 0.0126
Entamoeba histolytica hypothetical protein 0.0059 0.0239 0.5317
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0108 0.0482 0.1776
Plasmodium vivax vivapain-2 0.0012 0.0005 0.0001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0515 0.4351
Onchocerca volvulus 0.0047 0.018 0.0175
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0176 0.0654
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.0444 0.231
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0313 0.218
Echinococcus multilocularis musashi 0.0027 0.0078 0.0115
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0552 0.2691 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0021 0.0049 0.0997
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Trypanosoma brucei glucosidase, putative 0.0021 0.0049 0.0181
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0138 0.0187
Entamoeba histolytica hypothetical protein 0.002 0.0046 0.0935
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.0547 0.0813
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0039 0.0144
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1085 0.5649
Leishmania major alpha glucosidase II subunit, putative 0.0021 0.0049 0.0181
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0009 0.0041
Onchocerca volvulus 0.0055 0.0216 0.0211
Brugia malayi Glycosyl hydrolases family 31 protein 0.0021 0.0049 0.0065
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0031 0.0098
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0021 0.0049 0.031
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0014 0.005
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0039 0.026
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0005 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0547 0.3791
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0285 0.1994
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0049 0.031
Leishmania major telomerase reverse transcriptase, putative 0.0552 0.2691 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.012 0.2186
Onchocerca volvulus 0.0039 0.0138 0.0133
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0141 0.0647 0.4504
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.018 0.3975
Echinococcus granulosus lamin 0.0027 0.0078 0.0402
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0195 0.1009
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0099 0.0438 1
Brugia malayi jmjC domain containing protein 0.0102 0.045 0.0618
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0121 0.0818
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0579 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.0547 0.4617
Trypanosoma brucei heat shock protein 90, putative 0.0049 0.0187 0.0695
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.0444 0.066
Schistosoma mansoni hypothetical protein 0.0059 0.0239 0.1681
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0026 0.0074 0.0598
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0285 0.0422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0005 0.0003
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0195 0.0288
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0026 0.0075 0.0384
Brugia malayi glutaminase DH11.1 0.0296 0.142 0.1955
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0078 0.0331 0.2324
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0547 0.3791
Trichomonas vaginalis esterase, putative 0.0039 0.0138 0.094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0176 0.0654
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0005 0.0004
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0026 0.0168
Trypanosoma brucei heat shock protein 90, putative 0.0049 0.0187 0.0695
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0515 0.4351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0176 0.0654
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0031 0.0116
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0005 0.0005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0039 0.077
Echinococcus multilocularis cysteine protease 0.0012 0.0005 0.0006
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0108 0.0482 0.3373
Loa Loa (eye worm) hypothetical protein 0.0039 0.0138 0.0959
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0014 0.0032
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0032 0.0106 0.0101
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0014 0.005
Echinococcus multilocularis citrate lyase subunit beta protein 0.0026 0.0074 0.0109
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0014 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0331 0.1215
Echinococcus granulosus methyl CpG binding domain protein 2 0.0012 0.0006 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0049 0.0181
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0579 0.4893
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0005 0.0003
Trypanosoma brucei heat shock protein, putative 0.0049 0.0187 0.0695
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.045 0.0669
Echinococcus multilocularis expressed protein 0.0397 0.192 0.2859
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0031 0.0116
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0444 0.1652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0034 0.0116 0.0951
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0187 0.0695
Brugia malayi Protein cec-1. 0.0012 0.0005 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0444 0.3107
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0031 0.0186
Brugia malayi hypothetical protein 0.002 0.0046 0.0061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.064 0.0953
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.018 0.1495
Plasmodium falciparum cysteine proteinase falcipain 3 0.0012 0.0005 0.0001
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0099 0.035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0176 0.0654
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0118 0.0174
Echinococcus multilocularis cysteine protease 0.0012 0.0005 0.0006
Echinococcus granulosus tar DNA binding protein 0.0068 0.0285 0.1476
Entamoeba histolytica hypothetical protein 0.0059 0.0239 0.5317
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0048 0.0322
Toxoplasma gondii heat shock protein 75, putative 0.0032 0.0106 0.0375
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0547 0.385
Toxoplasma gondii UDP-glucose 4-epimerase 0.0052 0.0205 0.0746
Brugia malayi Cathepsin L-like precursor 0.0012 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0176 0.0654
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0116
Echinococcus granulosus lamin dm0 0.0027 0.0078 0.0402
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0046 0.0172 0.2804
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0444 0.3131
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0016 0.0026 0.0185
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0005 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0005 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0176 0.0654
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0014 0.0082
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0014 0.0082
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0046 0.0067
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0552 0.2691 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0021 0.0049 0.0247
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Echinococcus granulosus chromobox protein 1 0.0074 0.0313 0.1626
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.0126 0.047
Brugia malayi hypothetical protein 0.0229 0.1085 0.1494
Leishmania major cathepsin L-like protease 0.0046 0.0176 0.0654
Trypanosoma cruzi heat shock protein, putative 0.0032 0.0106 0.0392
Loa Loa (eye worm) hypothetical protein 0.0047 0.018 0.1254
Plasmodium falciparum thioredoxin reductase 0.0017 0.0031 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.064 0.4512
Echinococcus multilocularis lysosomal alpha glucosidase 0.0094 0.0414 0.0615
Loa Loa (eye worm) UDP galactose 4'-epimerase 0.0052 0.0205 0.1434
Trypanosoma brucei heat shock protein, putative 0.0049 0.0187 0.0695
Schistosoma mansoni alpha-glucosidase 0.0081 0.0349 0.2456
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Trichomonas vaginalis glutaminase, putative 0.0296 0.142 1
Trypanosoma cruzi hypothetical protein, conserved 0.0226 0.107 0.3978
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0111 0.0907
Loa Loa (eye worm) PHD-finger family protein 0.0015 0.0019 0.0123
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0192 0.1323
Leishmania major cathepsin L-like protease 0.0012 0.0005 0.0019
Schistosoma mansoni hypothetical protein 0.018 0.0841 0.5927
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0012 0.0055
Echinococcus multilocularis zinc finger protein 0.0014 0.0016 0.0021
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0515 0.4351
Trichomonas vaginalis endoplasmin, putative 0.0035 0.0121 0.0818
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.0444 0.3122
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0138 0.1139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0031 0.0116
Toxoplasma gondii cathepsin CPL 0.0012 0.0005 0.0001
Loa Loa (eye worm) heat shock protein 75 0.0032 0.0106 0.0732
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0176 0.0654
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.0547 0.2017
Loa Loa (eye worm) fibroinase 0.0012 0.0005 0.0024
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Schistosoma mansoni hypothetical protein 0.0087 0.0378 0.2661
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0031 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0005 0.0003
Brugia malayi MH2 domain containing protein 0.0127 0.0576 0.0792
Schistosoma mansoni UDP-glucose 4-epimerase 0.0052 0.0205 0.1445
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0008 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0039 0.0144
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0014 0.0032
Mycobacterium ulcerans lipase LipD 0.0039 0.0138 0.0884
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0696
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0039 0.0529
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0085 0.057
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0138 0.0512
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0151 0.1034
Trichomonas vaginalis heat shock protein, putative 0.0049 0.0187 0.1288
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0074 0.0276
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0005 0.0037
Loa Loa (eye worm) RNA binding protein 0.0068 0.0285 0.1994
Echinococcus multilocularis Chromo domain 0.0012 0.0005 0.0005
Toxoplasma gondii thioredoxin reductase 0.005 0.0195 0.0707
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0012 0.0006 0.0045
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0331 0.1231
Loa Loa (eye worm) helicase 0.0012 0.0005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0039 0.0138 0.0959
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0012 0.007
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0012 0.0083
Schistosoma mansoni alpha-glucosidase 0.0081 0.0349 0.2456
Trypanosoma brucei hypothetical protein, conserved 0.0226 0.107 0.3978
Plasmodium falciparum thioredoxin reductase 0.005 0.0195 0.0707
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0099 0.035
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0138 0.1139
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0187 0.0695
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0031 0.0098
Echinococcus granulosus geminin 0.018 0.0841 0.4378
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0138 0.0884
Brugia malayi PHD-finger family protein 0.0018 0.0035 0.0045
Trichomonas vaginalis sucrase-isomaltase, putative 0.0021 0.0049 0.031
Leishmania major trypanothione reductase 0.005 0.0195 0.0724
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0005 0.0003
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0074 0.0276
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0046 0.0172 0.064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.064 0.3331
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0313 0.2196
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0031 0.0126
Brugia malayi hypothetical protein 0.005 0.0194 0.0265
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.0515 0.8874
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0026 0.0168
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0138 0.0974
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0131 0.0194
Loa Loa (eye worm) ctsf protein 0.0012 0.0005 0.0024
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0099 0.0438 1
Mycobacterium ulcerans heat shock protein 90 0.0046 0.0172 0.1128
Brugia malayi beta-lactamase 0.0039 0.0138 0.0187
Plasmodium falciparum phd finger protein, putative 0.0031 0.0099 0.035
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.018 0.1181
Brugia malayi glutathione reductase 0.005 0.0195 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0291
Trypanosoma cruzi cruzipain precursor, putative 0.0046 0.0176 0.0654
Echinococcus granulosus cathepsin L cysteine proteinase 0.0012 0.0005 0.0021
Echinococcus multilocularis neutral alpha glucosidase AB 0.0021 0.0049 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0031 0.0116
Trypanosoma cruzi heat shock protein 90, putative 0.0042 0.0152 0.0565
Giardia lamblia Telomerase catalytic subunit 0.0552 0.2691 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0116
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.1022
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0012 0.0005 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0444 0.3107
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0138 0.1139
Entamoeba histolytica heat shock protein 90, putative 0.0049 0.0187 0.4144
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0012 0.0005 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0049 0.031
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0049 0.0181
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0046 0.0172 0.1431
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0138 0.094
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0026 0.0095
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0014 0.005
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0046 0.0324
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0138 0.094
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0285 0.2004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Brugia malayi PXA domain containing protein 0.002 0.0046 0.0061
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0014 0.005
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0195 0.1624
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0138 0.0495
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0444 0.1652
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0046 0.0061
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0127 0.0578 0.4066
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0138 0.0884
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0138 0.0971
Onchocerca volvulus 0.0014 0.0014 0.0009
Leishmania major hypothetical protein, conserved 0.0226 0.107 0.3978
Loa Loa (eye worm) latrophilin receptor protein 2 0.004 0.0145 0.101
Giardia lamblia Heat shock protein HSP 90-alpha 0.0049 0.0187 0.0586
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0285 0.1994
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0026 0.0168
Brugia malayi Bromodomain containing protein 0.0033 0.0107 0.0146
Echinococcus multilocularis cathepsin L cysteine protease 0.0012 0.0005 0.0006
Brugia malayi jmjC domain containing protein 0.0039 0.0138 0.0188
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0046 0.0172 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0138 0.0959
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0138 0.0203
Giardia lamblia UDP-glucose 4-epimerase 0.0055 0.0216 0.0694
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Echinococcus granulosus intermediate filament protein 0.0027 0.0078 0.0402
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.012 0.0758
Loa Loa (eye worm) hypothetical protein 0.0035 0.012 0.0834
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0046 0.0067
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0138 0.094
Echinococcus multilocularis cathepsin L cysteine protease 0.0012 0.0005 0.0006
Brugia malayi Glycosyl hydrolases family 31 protein 0.0094 0.0414 0.0568
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0108 0.0482 0.1776
Schistosoma mansoni chromobox protein 0.0012 0.0005 0.0034
Loa Loa (eye worm) cysteine protease 0.0012 0.0005 0.0024
Loa Loa (eye worm) glutaminase 2 0.0296 0.142 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0149 0.1036
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0094 0.0414 0.2907
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.018 0.2936
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0005 0.0003
Trypanosoma cruzi UDP-galactose 4-epimerase 0.0052 0.0205 0.0762
Loa Loa (eye worm) hypothetical protein 0.0028 0.0084 0.0577
Plasmodium vivax vivapain-2 0.0012 0.0005 0.0001
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0031 0.0232
Trypanosoma brucei heat shock protein, putative 0.0049 0.0187 0.0695
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0024
Schistosoma mansoni intermediate filament proteins 0.0027 0.0078 0.0552
Giardia lamblia Heat shock protein HSP 90-alpha 0.0042 0.0152 0.0454
Plasmodium falciparum heat shock protein 90, putative 0.0185 0.0864 0.3197
Echinococcus granulosus Chromo domain 0.0012 0.0005 0.0019
Brugia malayi Cytochrome P450 family protein 0.0016 0.0026 0.0033
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0026 0.0074 0.0431
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0331 0.1231
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0046 0.0067
Trypanosoma cruzi cysteine peptidase, putative 0.0012 0.0005 0.0019
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0014 0.005
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.1179 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0014 0.0016
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0031 0.022
Brugia malayi Heterochromatin protein 1 0.0074 0.0313 0.0429
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0046 0.0324
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0082
Echinococcus granulosus chromobox protein 1 0.0074 0.0313 0.1626
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Brugia malayi chromobox protein homolog 3 0.0042 0.0151 0.0206
Toxoplasma gondii heat shock protein 90, putative 0.0049 0.0187 0.0678
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0068 0.0282 0.2363
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0031 0.0116
Onchocerca volvulus 0.0027 0.0078 0.0073
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0138 0.0974
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.012 0.0429
Echinococcus granulosus fetal alzheimer antigen falz 0.0016 0.0026 0.013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0059 0.0239 0.1237
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0014 0.0095
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0046 0.0067
Trypanosoma brucei heat shock protein, putative 0.0049 0.0187 0.0695
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0031 0.0116
Mycobacterium tuberculosis Conserved protein 0.0026 0.0074 0.0598
Brugia malayi AMP-binding enzyme family protein 0.0047 0.018 0.0245
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0046 0.0233
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0042 0.0152 0.0786
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.136 0.6711 1
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0046 0.0067
Plasmodium falciparum heat shock protein 90 0.0049 0.0187 0.0678
Brugia malayi Telomerase reverse transcriptase 0.1469 0.7253 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0026 0.0075 0.011
Echinococcus granulosus peregrin 0.0033 0.0107 0.0553
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0099 0.0438 0.1628
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0046 0.0061
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0012 0.0006 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0091 0.0608
Echinococcus multilocularis geminin 0.018 0.0841 0.1252
Loa Loa (eye worm) glutaminase 0.0296 0.142 1
Echinococcus multilocularis heat shock protein 90 0.0049 0.0187 0.0277
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0138 0.1139
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0026 0.0095
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0331 0.1215
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0012 0.0016
Leishmania major hypothetical protein, conserved 0.0078 0.0331 0.1231
Loa Loa (eye worm) endoplasmin 0.0049 0.0187 0.1306
Loa Loa (eye worm) oxidoreductase 0.0014 0.0014 0.0082
Mycobacterium ulcerans beta-lactamase 0.0039 0.0138 0.0884
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0046 0.0061
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.018 0.1495
Plasmodium vivax heat shock protein 86, putative 0.0049 0.0187 0.0678
Trypanosoma brucei heat shock protein, putative 0.0049 0.0187 0.0695
Brugia malayi Cytochrome P450 family protein 0.0016 0.0026 0.0033
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.0444 1
Brugia malayi RNA binding protein 0.0068 0.0285 0.039
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0014 0.0016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.064 0.4505
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0444 0.3107
Mycobacterium tuberculosis Probable reductase 0.0115 0.0515 0.4351
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0014 0.005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0039 0.0195
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.0547 0.2031
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0444 0.3107
Brugia malayi Cathepsin L-like precursor 0.0012 0.0005 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0014 0.0016
Loa Loa (eye worm) heat shock protein 90 0.0049 0.0187 0.1306
Echinococcus granulosus UDP glucose 4 epimerase 0.0052 0.0205 0.1063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.064 0.3331
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.004 0.0145 0.0749
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0515 0.4351
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0074 0.0431
Echinococcus multilocularis endoplasmin 0.0046 0.0172 0.0255
Loa Loa (eye worm) hypothetical protein 0.0047 0.018 0.1254
Echinococcus multilocularis heat shock protein 0.0049 0.0187 0.0277
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0311
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.1022
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0046 0.0233
Brugia malayi Cathepsin L-like precursor 0.0012 0.0005 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.018 0.0667
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0005 0.0024
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0346 0.2437
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0005 0.0019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0138 0.0959
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0046 0.0324
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0099 0.0696
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0039 0.0126
Loa Loa (eye worm) hypothetical protein 0.0033 0.0107 0.0738
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0167 0.1145
Entamoeba histolytica hypothetical protein 0.002 0.0046 0.0935
Plasmodium vivax heat shock protein, putative 0.0185 0.0864 0.3197
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0285 0.2004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0031 0.0116
Onchocerca volvulus 0.0039 0.0138 0.0133
Brugia malayi hypothetical protein 0.002 0.0046 0.0061
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0008 0.0009
Toxoplasma gondii RNA-directed DNA polymerase 0.0552 0.2691 1
Brugia malayi Latrophilin receptor protein 2 0.004 0.0145 0.0197
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.018 0.3975
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0176 0.0654
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0031 0.0098
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0039 0.0296
Loa Loa (eye worm) hypothetical protein 0.0039 0.0138 0.0959
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0108 0.0482 0.1695
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0039 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0021
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0039 0.0056
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0026 0.0074 0.049
Brugia malayi heat shock protein 90 0.0049 0.0187 0.0255
Brugia malayi beta-lactamase family protein 0.0039 0.0138 0.0187
Schistosoma mansoni endoplasmin 0.0049 0.0187 0.1317
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.0547 0.2842
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0016 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0576 0.4052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0014 0.0082
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0032 0.0106 0.2292
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0138 0.1139
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0138 0.094
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0014 0.0061
Trypanosoma cruzi heat shock protein 90, putative 0.0049 0.0187 0.0695
Brugia malayi TAR-binding protein 0.0068 0.0285 0.039
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0039 0.0183
Leishmania major cathepsin L-like protease 0.0046 0.0176 0.0654
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0167 0.0162
Schistosoma mansoni axis inhibition protein axin 0.002 0.0046 0.0324
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0014 0.0064
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0031 0.0116
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0138 0.0971
Schistosoma mansoni methyl-cpg binding protein mbd 0.0012 0.0006 0.0045
Schistosoma mansoni alpha glucosidase 0.0021 0.0049 0.0343
Trypanosoma brucei telomerase reverse transcriptase 0.0552 0.2691 1
Schistosoma mansoni endoplasmin 0.0049 0.0187 0.1317
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0014 0.0082
Leishmania major udp-glc 4-epimerase, putative 0.0055 0.0216 0.0802
Trypanosoma cruzi UDP-galactose 4-epimerase, putative 0.0052 0.0205 0.0762
Schistosoma mansoni transcription factor LCR-F1 0.0059 0.0239 0.1681
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0044 0.0161 0.0833
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0039 0.0126
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0042 0.0156 0.0579
Trypanosoma brucei heat shock protein, putative 0.0049 0.0187 0.0695
Brugia malayi beta-lactamase family protein 0.0039 0.0138 0.0187
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0547 0.3791
Schistosoma mansoni chromobox protein 0.0074 0.0313 0.2207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0031 0.0116
Leishmania major cathepsin L-like protease 0.0012 0.0005 0.0019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0039 0.0144
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0031 0.0186
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0159 0.0235
Echinococcus granulosus lysosomal alpha glucosidase 0.0094 0.0414 0.2151
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0005 0.0004
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.018 0.1181
Schistosoma mansoni heat shock protein 0.0049 0.0187 0.1317
Plasmodium vivax telomerase reverse transcriptase, putative 0.0552 0.2691 1
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0331 0.1231
Echinococcus granulosus cathepsin l cysteine peptidase 0.0012 0.0005 0.0021
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0049 0.031
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.018 0.1181
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0141 0.0647 0.547
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0091 0.0608
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0311
Echinococcus granulosus heat shock protein 90 0.0049 0.0187 0.0968
Echinococcus multilocularis heat shock protein 90 0.0042 0.0152 0.0225
Brugia malayi AMP-binding enzyme family protein 0.0047 0.018 0.0245
Brugia malayi Endoplasmin precursor 0.0049 0.0187 0.0255
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0014 0.0197
Schistosoma mansoni zinc finger protein 0.0014 0.0016 0.0109
Echinococcus multilocularis lamin dm0 0.0027 0.0078 0.0115
Echinococcus multilocularis lysosomal alpha glucosidase 0.0094 0.0414 0.0615
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0078 0.0539
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0285 0.2004
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0291
Entamoeba histolytica cysteine protease, putative 0.0012 0.0005 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0005 0.0003
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0138 0.0512
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0099 0.0438 0.1628
Brugia malayi Bromodomain containing protein 0.0055 0.0217 0.0296
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0138 0.0712
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0021 0.0049 0.033
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.018 0.2936
Plasmodium vivax glutathione reductase, putative 0.005 0.0195 0.0707
Loa Loa (eye worm) hypothetical protein 0.0035 0.012 0.0834
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0099 0.0438 0.3086
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.018 0.1181
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0012 0.0005 0.0001
Trypanosoma brucei UDP-galactose 4-epimerase 0.0055 0.0216 0.0802
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1085 0.1615
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0021 0.0049 0.0997
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0177 0.0242
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0032 0.0106 0.0156
Brugia malayi hypothetical protein 0.0012 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.0059 0.0239 0.5317
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.018 0.3975
Brugia malayi intermediate filament protein 0.0027 0.0078 0.0105
Schistosoma mansoni heat shock protein 0.0032 0.0106 0.0744
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0014 0.0032
Schistosoma mansoni lamin 0.0027 0.0078 0.0552
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0026 0.0095
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0099 0.0438 0.3077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.004 0.0145 0.0749
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0065 0.0267 0.1802
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0046 0.0067
Brugia malayi CHD4 protein 0.0014 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0291
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0052 0.0205 0.1416
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0005 0.0003
Echinococcus multilocularis chromobox protein 2 0.0012 0.0005 0.0005
Brugia malayi Bromodomain containing protein 0.0028 0.0083 0.0112
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0167 0.1145
Giardia lamblia Kinase, PLK 0.01 0.0444 0.1553
Schistosoma mansoni survival motor neuron protein 0.0047 0.0177 0.1248
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0522
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0579 0.4893
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0021 0.0049 0.0163
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0078 0.0105
Loa Loa (eye worm) hypothetical protein 0.0087 0.0378 0.2652
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0031 0.0116
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0285 0.039
Echinococcus granulosus chromobox protein 2 0.0012 0.0005 0.0019
Onchocerca volvulus 0.0014 0.0014 0.0009
Plasmodium falciparum endoplasmin, putative 0.0035 0.0121 0.0431
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0034
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0012 0.0006 0.0045
Echinococcus multilocularis peregrin 0.0033 0.0107 0.0158
Plasmodium falciparum telomerase reverse transcriptase 0.0552 0.2691 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0012 0.0005 0.0006
Brugia malayi glucose-6-phosphate dehydrogenase 0.0099 0.0438 0.0601
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0138 0.0714
Leishmania major cathepsin L-like protease 0.0012 0.0005 0.0019
Plasmodium falciparum glutathione reductase 0.0017 0.0031 0.0098
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0005 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0444 0.3107
Trypanosoma cruzi hypothetical protein, conserved 0.0226 0.107 0.3978
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.064 0.0881
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0046 0.0233
Echinococcus granulosus endoplasmin 0.0046 0.0172 0.0891
Brugia malayi Cathepsin L-like precursor 0.0012 0.0005 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0031 0.0116
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0033 0.0108 0.0401
Echinococcus granulosus GPCR family 2 0.004 0.0145 0.0749
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0016 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0021
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0046 0.0291
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0039 0.0239
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0039 0.0239
Schistosoma mansoni heat shock protein 0.0049 0.0187 0.1317
Echinococcus multilocularis UDP glucose 4 epimerase 0.0052 0.0205 0.0304
Onchocerca volvulus 0.0047 0.0177 0.0172
Echinococcus multilocularis chromobox protein 1 0.0074 0.0313 0.0465
Onchocerca volvulus Alhambra homolog 0.0031 0.0099 0.0094
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0048 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0176 0.0654
Brugia malayi Cathepsin L-like precursor 0.0012 0.0005 0.0005
Schistosoma mansoni regulator of G protein signaling 0.002 0.0046 0.0324
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0291
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0012 0.0006 0.0008
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0014 0.005
Echinococcus multilocularis GPCR, family 2 0.004 0.0145 0.0214
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0016 0.0101
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Entamoeba histolytica hypothetical protein 0.0059 0.0239 0.5317
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0014 0.005
Loa Loa (eye worm) bromodomain containing protein 0.0013 0.0009 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0082
Schistosoma mansoni bromodomain containing protein 0.0046 0.0174 0.1226
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0046 0.0067
Schistosoma mansoni glutaminase 0.0296 0.142 1
Schistosoma mansoni ap endonuclease 0.0019 0.0039 0.0273
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0031 0.004
Echinococcus granulosus cathepsin l1 0.0012 0.0005 0.0021
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0031 0.0098
Loa Loa (eye worm) glutathione reductase 0.005 0.0195 0.1361
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0046 0.0061
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0052 0.0205 0.1416
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0311
Echinococcus granulosus axis inhibition protein axin 0.002 0.0046 0.0233
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0285 0.2004
Entamoeba histolytica hypothetical protein 0.002 0.0046 0.0935
Trypanosoma brucei polo-like protein kinase 0.01 0.0444 0.1652
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0138 0.2197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0031 0.0116
Trypanosoma brucei heat shock protein 84, putative 0.0032 0.0106 0.0392
Loa Loa (eye worm) hypothetical protein 0.0042 0.0151 0.1053
Loa Loa (eye worm) hypothetical protein 0.003 0.0092 0.0638
Loa Loa (eye worm) hypothetical protein 0.0035 0.012 0.0834
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0012 0.0005 0.0003
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0078 0.0539
Leishmania major cathepsin L-like protease 0.0046 0.0176 0.0654
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0111 0.0907
Plasmodium falciparum heat shock protein 90, putative 0.0028 0.0085 0.03
Schistosoma mansoni lamin 0.0027 0.0078 0.0552
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0014 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0176 0.0654
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0046 0.0324
Mycobacterium leprae Probable lipase LipE 0.0039 0.0138 0.2197
Schistosoma mansoni regulator of G protein signaling 0.002 0.0046 0.0324
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.018 0.0667
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.004 0.0145 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0311
Mycobacterium tuberculosis Conserved protein 0.0039 0.0138 0.1139
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0046 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0291
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0159 0.0823
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0005 0.0034
Toxoplasma gondii heat shock protein HSP90 0.0049 0.0187 0.0678
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0176 0.0654
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0136
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0005 0.0034
Leishmania major hypothetical protein, conserved 0.0039 0.0138 0.0512
Entamoeba histolytica heat shock protein 90, putative 0.0049 0.0187 0.4144
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0032 0.0106 0.0544
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0138 0.1139
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0026 0.0086
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0014 0.0018
Plasmodium falciparum glutathione reductase 0.005 0.0195 0.0707
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0021
Echinococcus granulosus zinc finger protein 0.0014 0.0016 0.0074
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0005 0.0005
Schistosoma mansoni regulator of G protein signaling 0.002 0.0046 0.0324
Echinococcus granulosus Chromobox protein 3 0.0012 0.0005 0.0019
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0099 0.0438 0.0651
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0014 0.0032
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0031 0.0098
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0099 0.0508
Trypanosoma brucei Heat shock protein 83, putative 0.0049 0.0187 0.0695
Toxoplasma gondii ABC1 family protein 0.0039 0.0138 0.0495
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.018 0.1181
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.018 0.0667
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0031 0.0116
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0579 0.4893
Brugia malayi SET domain containing protein 0.0012 0.0005 0.0004
Brugia malayi Cytochrome P450 family protein 0.0041 0.0149 0.0203
Loa Loa (eye worm) hypothetical protein 0.0035 0.012 0.0834
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0039 0.0144
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0048 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0151 0.1034
Schistosoma mansoni regulator of G protein signaling 0.002 0.0046 0.0324
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0285 0.2004
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0031 0.0116
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0021
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.012 0.0429
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0044 0.0161 0.0238
Schistosoma mansoni ap endonuclease 0.0019 0.0039 0.0273
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0021
Onchocerca volvulus 0.0033 0.0107 0.0102
Schistosoma mansoni hypothetical protein 0.018 0.0841 0.5927
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0046 0.0067
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0074 0.0431
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0074 0.0276
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0014 0.0082
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0014 0.0082
Echinococcus multilocularis chromobox protein 1 0.0074 0.0313 0.0465
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0048 0.0242
Loa Loa (eye worm) beta-lactamase 0.0039 0.0138 0.0959
Onchocerca volvulus 0.0014 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0138 0.0959
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0046 0.0233
Echinococcus granulosus histone lysine methyltransferase setb 0.0012 0.0006 0.0027
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0014 0.005
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0547 0.385
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.004 0.0145 0.0214
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0046 0.0233
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0046 0.0311
Onchocerca volvulus 0.0039 0.0138 0.0133
Loa Loa (eye worm) hypothetical protein 0.004 0.0145 0.101
Trypanosoma cruzi heat shock protein 85, putative 0.0042 0.0152 0.0565
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.064 0.0953
Toxoplasma gondii exonuclease III APE 0.0019 0.0039 0.0126
Brugia malayi Cathepsin L-like precursor 0.0012 0.0005 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0014 0.0016
Schistosoma mansoni regulator of G protein signaling 0.002 0.0046 0.0324
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0099 0.0438 0.1628
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.0444 0.044
Echinococcus granulosus expressed protein 0.0397 0.192 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0111 0.0907
Mycobacterium ulcerans hypothetical protein 0.0047 0.018 0.1181
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0331 0.1215
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0187 0.0695
Loa Loa (eye worm) hypothetical protein 0.0229 0.1085 0.7642
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0176 0.0654
Leishmania major cathepsin L-like protease 0.0012 0.0005 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0034
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0152 0.104
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0172 0.1182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0099 0.0684
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0014 0.0082
Leishmania major heat shock protein, putative 0.0032 0.0106 0.0392
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0032 0.0103 0.0384
Plasmodium vivax endoplasmin, putative 0.0049 0.0187 0.0678
Brugia malayi hypothetical protein 0.0078 0.0331 0.0454
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0014 0.0082
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0313 0.218
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0009 0.0012
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0065 0.0267 0.0975
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0048 0.0335
Brugia malayi hypothetical protein 0.0059 0.0239 0.0326
Trypanosoma brucei beta lactamase 0.0068 0.0282 0.1047
Treponema pallidum heat shock protein 90 0.0046 0.0172 0.3463
Schistosoma mansoni hypothetical protein 0.0035 0.0118 0.0831
Leishmania major heat shock protein 83-1 0.0049 0.0187 0.0695
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0195 0.0724
Mycobacterium ulcerans hypothetical protein 0.0039 0.0138 0.0884
Mycobacterium tuberculosis Conserved protein 0.0039 0.0138 0.1139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.0003
Echinococcus multilocularis lamin 0.0027 0.0078 0.0115
Brugia malayi UDP galactose 4'-epimerase 0.0052 0.0205 0.028
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0048 0.0069

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Agonist activity at NOD1 receptor (unknown origin) expressed in HEK-Blue cells assessed as NF-kappaB transcriptional activity at 20 uM after 18 hrs by secreted embryonic alkaline phosphatase reporter gene assay ChEMBL. 27039337
Activity (functional) = 42.5 % Immunosuppressive effect in human PBMC cells assessed as increase in PMS/ionomycin-induce IL-6 release at 20.2 uM after 18 hrs by flow cytometry analysis relative to PMA and ionomycin ChEMBL. 21669478
Activity (functional) = 63.5 % Immunosuppressive effect in human PBMC cells assessed as increase in PMS/ionomycin-induce TNFalpha release at 20.2 uM after 18 hrs by flow cytometry analysis relative to PMA and ionomycin ChEMBL. 21669478
Activity (functional) = 68.5 % Immunomodulatory effect in human PBMC cells assessed as decrease in LPS-induced IL-10 release at 20.2 uM after 18 hrs by flow cytometry analysis relative to LPS ChEMBL. 21669478
Activity (functional) = 75.8 % Immunosuppressive effect in human PBMC cells assessed as increase in PMS/ionomycin-induce IL-10 release at 20.2 uM after 18 hrs by flow cytometry analysis relative to PMA and ionomycin ChEMBL. 21669478
Activity (functional) = 76.8 % Immunomodulatory effect in human PBMC cells assessed as decrease in LPS-induced IL-6 release at 20.2 uM after 18 hrs by flow cytometry analysis relative to LPS ChEMBL. 21669478
Activity (functional) = 78 % Immunomodulatory effect in human PBMC cells assessed as LPS-induced IL1-beta release at 20.2 uM after 18 hrs by flow cytometry analysis relative to LPS ChEMBL. 21669478
Activity (functional) = 90 % Immunosuppressive effect in human PBMC cells assessed as increase in PMS/ionomycin-induce IL-8a release at 20.2 uM after 18 hrs by flow cytometry analysis relative to PMA and ionomycin ChEMBL. 21669478
Activity (functional) = 95.5 % Immunomodulatory effect in human PBMC cells assessed as decrease in LPS-induced IL-8a release at 20.2 uM after 18 hrs by flow cytometry analysis relative to LPS ChEMBL. 21669478
Activity (functional) = 96.5 % Immunosuppressive effect in human PBMC cells assessed as increase in PMS/ionomycin-induce IL1-beta release at 20.2 uM after 18 hrs by flow cytometry analysis relative to PMA and ionomycin ChEMBL. 21669478
Activity (functional) = 103.5 % Immunomodulatory effect in human PBMC cells assessed as increase in LPS-induced TNFalpha release at 20.2 uM after 18 hrs by flow cytometry analysis relative to LPS ChEMBL. 21669478
Activity (functional) = 118.5 % Immunomodulatory effect in human THP1 cells assessed as increase in LPS-induced TNF-alpha release at 20.2 uM after 24 hrs by sandwich ELISA relative to LPS ChEMBL. 21669478
FC (binding) = 2.1 Agonist activity at NOD2 receptor (unknown origin) expressed in HEK-Blue cells assessed as NF-kappaB transcriptional activity at 20 uM after 18 hrs by secreted embryonic alkaline phosphatase reporter gene assay relative to untreated control ChEMBL. 27039337

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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