Detailed information for compound 1038780

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 564.692 | Formula: C35H37FN4O2
  • H donors: 1 H acceptors: 2 LogP: 6.37 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN(C(=O)C(c1ccccc1)N1CCN(CC1)c1ccc(cc1F)NC(=O)c1ccccc1c1ccccc1)CC
  • InChi: 1S/C35H37FN4O2/c1-3-38(4-2)35(42)33(27-15-9-6-10-16-27)40-23-21-39(22-24-40)32-20-19-28(25-31(32)36)37-34(41)30-18-12-11-17-29(30)26-13-7-5-8-14-26/h5-20,25,33H,3-4,21-24H2,1-2H3,(H,37,41)
  • InChiKey: LXPTUYINJHUIPI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide Y receptor Y2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis G protein coupled receptor 139 Get druggable targets OG5_127863 All targets in OG5_127863
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Get druggable targets OG5_127863 All targets in OG5_127863
Schistosoma mansoni neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor neuropeptide Y receptor Y2 381 aa 388 aa 20.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0307 0.1032
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.2919 0.8377
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0073 0.021
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0266 0.0748
Mycobacterium tuberculosis Conserved protein 0.0038 0.0266 0.1058
Entamoeba histolytica protein kinase, putative 0.0065 0.0552 0.157
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0213 0.0845
Brugia malayi Fibronectin type III domain containing protein 0.005 0.0393 0.1113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0213 0.0845
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0672
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.005 0.0393 0.0387
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0404 0.058
Leishmania major importin beta-1 subunit, putative 0.0024 0.0113 0.0368
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0184 0.0264
Onchocerca volvulus Tyrosine kinase homolog 0.0289 0.2931 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0032 0.0201 0.0794
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0089 0.0241
Brugia malayi RNA binding protein 0.0065 0.0549 0.1563
Loa Loa (eye worm) hypothetical protein 0.0061 0.0509 0.1463
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0196 0.3487
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0266 0.026
Mycobacterium tuberculosis Conserved protein 0.0038 0.0266 0.1058
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.019 0.1879 0.54
Echinococcus multilocularis 0.0032 0.0201 0.0289
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0032 0.0201 0.067
Echinococcus granulosus aurora kinase A 0.0065 0.0552 0.0793
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.2919 0.8377
Leishmania major protein kinase, putative 0.0065 0.0552 0.1875
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0032 0.0201 0.0794
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0032 0.0201 0.0794
Brugia malayi hypothetical protein 0.004 0.0281 0.0793
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0025 0.0056
Echinococcus granulosus lysosomal alpha glucosidase 0.019 0.1879 0.2698
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0357 0.0351
Loa Loa (eye worm) hypothetical protein 0.005 0.0393 0.1128
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0404 0.058
Loa Loa (eye worm) oxidoreductase 0.0014 0.0006 0.0017
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0167 0.1629 1
Onchocerca volvulus 0.028 0.2831 0.9659
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0133 0.019
Loa Loa (eye worm) AUR protein kinase 0.0065 0.0552 0.1586
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0281 0.0276
Entamoeba histolytica protein kinase , putative 0.0065 0.0552 0.157
Schistosoma mansoni hypothetical protein 0.0194 0.1921 0.1917
Trichomonas vaginalis set domain proteins, putative 0.0252 0.2541 0.7291
Giardia lamblia Fructose-bisphosphate aldolase 0.0341 0.3484 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0361 0.2189
Loa Loa (eye worm) hypothetical protein 0.0057 0.0465 0.1337
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0032 0.0201 0.1202
Loa Loa (eye worm) hypothetical protein 0.0039 0.0273 0.0785
Toxoplasma gondii aurora kinase 0.0065 0.0552 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0307 0.044
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0032 0.0201 0.1202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0361 0.1446
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0032 0.0201 0.0794
Brugia malayi RNA, U transporter 1 0.0084 0.0752 0.2148
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0025 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0266 0.0893
Mycobacterium ulcerans beta-lactamase 0.0038 0.0266 0.1603
Schistosoma mansoni vesicular amine transporter 0.005 0.0393 0.0387
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0296 0.0424
Loa Loa (eye worm) CYP4Cod1 0.0048 0.0372 0.1068
Loa Loa (eye worm) hypothetical protein 0.0028 0.0152 0.0437
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.3484 1
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0372 0.1256
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0196 0.0282
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0361 0.1023
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0152 0.0421
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0266 0.1058
Brugia malayi hypothetical protein 0.005 0.0393 0.1113
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0266 0.1603
Echinococcus multilocularis neuroglian 0.0055 0.0444 0.0637
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0361 0.1022
Schistosoma mansoni hypothetical protein 0.0032 0.0201 0.0195
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0032 0.0201 0.0794
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0552 0.0546
Echinococcus multilocularis muscleblind protein 1 0.0165 0.1615 0.2319
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0032 0.0201 0.1202
Schistosoma mansoni lamin 0.0028 0.0152 0.0146
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0066 0.006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0234 0.0928
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0032 0.0201 0.1202
Schistosoma mansoni bromodomain containing protein 0.0072 0.0629 0.0623
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0032 0.0201 0.0794
Schistosoma mansoni hypothetical protein 0.0018 0.0044 0.0039
Mycobacterium ulcerans hypothetical protein 0.0038 0.0266 0.1603
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0006 0.0008
Echinococcus multilocularis lamin dm0 0.0028 0.0152 0.0218
Echinococcus granulosus cytochrome P450 2K1 0.0032 0.0201 0.0289
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0552 0.157
Echinococcus multilocularis muscleblind protein 0.0165 0.1615 0.2319
Entamoeba histolytica hypothetical protein 0.004 0.0281 0.0792
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0032 0.0201 0.1202
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0341 0.348 1
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0113 0.0308
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0288 0.2919 0.4192
Echinococcus multilocularis Immunoglobulin 0.005 0.0393 0.0564
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.3484 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0201 0.067
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0361 0.1022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.005 0.0072
Echinococcus granulosus snurportin 1 0.0316 0.3213 0.4614
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0307 0.0865
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0266 0.0893
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0266 0.1058
Brugia malayi Pre-SET motif family protein 0.0032 0.0196 0.0548
Schistosoma mansoni ran 0.0022 0.0089 0.0084
Plasmodium vivax importin-beta 2, putative 0.003 0.0172 0.3051
Onchocerca volvulus 0.0028 0.0152 0.05
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0357 0.0512
Brugia malayi Bromodomain containing protein 0.0086 0.0771 0.2203
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0552 0.157
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0144
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0089 0.0287
Echinococcus granulosus geminin 0.0194 0.1921 0.2759
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0266 0.0748
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0307 0.0865
Loa Loa (eye worm) hypothetical protein 0.003 0.0172 0.0496
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0089 0.1531
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0089 0.0128
Brugia malayi serine/threonine-protein kinase plk-2 0.0288 0.2919 0.8387
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0089 0.0287
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0032 0.0201 0.1202
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0089 0.1531
Onchocerca volvulus 0.0032 0.0196 0.0651
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0065 0.0552 0.0793
Loa Loa (eye worm) hypothetical protein 0.0038 0.0266 0.0764
Brugia malayi PHD-finger family protein 0.0029 0.0161 0.0448
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.3484 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0032 0.0201 0.1202
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0341 0.3484 1
Schistosoma mansoni hypothetical protein 0.0316 0.3213 0.3209
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0549 0.0543
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0307 0.044
Brugia malayi TAR-binding protein 0.0065 0.0549 0.1563
Schistosoma mansoni Neurotrimin precursor (hNT) 0.005 0.0393 0.0387
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0066 0.006
Trichomonas vaginalis ran, putative 0.0022 0.0089 0.024
Loa Loa (eye worm) hypothetical protein 0.0056 0.0458 0.1316
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0341 0.3484 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0288 0.2919 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0201 0.067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0357 0.0351
Schistosoma mansoni hypothetical protein 0.0024 0.0109 0.0104
Schistosoma mansoni ran 0.0022 0.0089 0.0084
Onchocerca volvulus 0.011 0.1027 0.3491
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0465 0.1322
Loa Loa (eye worm) hypothetical protein 0.0047 0.0354 0.1018
Echinococcus multilocularis Immunoglobulin 0.005 0.0393 0.0564
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0032 0.0201 0.1202
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0672
Onchocerca volvulus 0.0252 0.2541 0.8668
Loa Loa (eye worm) hypothetical protein 0.0165 0.1615 0.4641
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0113 0.0308
Schistosoma mansoni lamin 0.0028 0.0152 0.0146
Entamoeba histolytica hypothetical protein 0.0024 0.0113 0.0308
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0032 0.0201 0.1202
Schistosoma mansoni hypothetical protein 0.004 0.0281 0.0276
Loa Loa (eye worm) hypothetical protein 0.0047 0.0361 0.1038
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0552 0.157
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0065 0.0552 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0065 0.0552 0.157
Mycobacterium leprae putative cytochrome p450 0.0032 0.0201 0.1202
Entamoeba histolytica hypothetical protein 0.004 0.0281 0.0792
Echinococcus granulosus intermediate filament protein 0.0028 0.0152 0.0218
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0089 0.0257
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0361 0.122
Echinococcus granulosus neuropeptide receptor 0.0188 0.1857 0.2667
Brugia malayi cytochrome P450 0.0032 0.0201 0.0562
Onchocerca volvulus 0.0028 0.0152 0.05
Trypanosoma cruzi ISWI complex protein 0.0018 0.0044 0.0132
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0672
Echinococcus multilocularis snurportin 1 0.0316 0.3213 0.4614
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0172 0.3051
Loa Loa (eye worm) hypothetical protein 0.0044 0.0325 0.0935
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0266 0.1603
Loa Loa (eye worm) RNA binding protein 0.0065 0.0549 0.1577
Plasmodium falciparum serine/threonine protein kinase, putative 0.0065 0.0552 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0017
Echinococcus multilocularis neuropeptide receptor 0.0188 0.1857 0.2667
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0234 0.4178
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0372 0.1068
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0133 0.0127
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0307 0.0865
Mycobacterium leprae Conserved hypothetical protein 0.0032 0.0201 0.1202
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0266 0.0748
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0266 0.0893
Echinococcus granulosus muscleblind protein 0.0165 0.1615 0.2319
Echinococcus multilocularis basement membrane specific heparan sulfate 0.005 0.0393 0.0564
Loa Loa (eye worm) AUR protein kinase 0.0065 0.0552 0.1586
Mycobacterium ulcerans lipase LipD 0.0038 0.0266 0.1603
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0032 0.0201 0.1202
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0281 0.0404
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0585 0.084
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0032 0.0201 0.0794
Brugia malayi Muscleblind-like protein 0.0165 0.1615 0.4632
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0032 0.0201 0.1202
Schistosoma mansoni alpha glucosidase 0.0042 0.0307 0.0301
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0065 0.0552 0.157
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0172 0.0572
Echinococcus multilocularis geminin 0.0194 0.1921 0.2759
Trypanosoma cruzi polo-like protein kinase, putative 0.0288 0.2919 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0296 0.0424
Schistosoma mansoni hypothetical protein 0.0039 0.0273 0.0267
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0032 0.0201 0.0794
Brugia malayi beta-lactamase family protein 0.0038 0.0266 0.0749
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0032 0.0201 0.0794
Onchocerca volvulus 0.0047 0.0361 0.1215
Echinococcus multilocularis G protein coupled receptor 139 0.0188 0.1857 0.2667
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0307 0.0865
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0167 0.1629 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0032 0.0201 0.0794
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0113 0.0368
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0006 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0361 0.122
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.1879 0.2698
Echinococcus multilocularis importin subunit beta 1 0.003 0.0172 0.0248
Toxoplasma gondii ABC1 family protein 0.0038 0.0266 0.4764
Brugia malayi serine/threonine kinase 12 0.0065 0.0552 0.1572
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0361 0.2189
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0025 0.0056
Onchocerca volvulus 0.0038 0.0266 0.0889
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0307 0.1032
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0266 0.4764
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0089 0.1531
Trichomonas vaginalis esterase, putative 0.0038 0.0266 0.0748
Loa Loa (eye worm) hypothetical protein 0.0165 0.1615 0.4641
Echinococcus granulosus defective proboscis extension response 0.005 0.0393 0.0564
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0152 0.0437
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0113 0.0308
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0307 0.0865
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0549 0.0543
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.2919 0.8377
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0032 0.0201 0.1202
Schistosoma mansoni alpha-glucosidase 0.0164 0.1598 0.1593
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0361 0.1022
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0234 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0357 0.0351
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.005 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0288 0.2919 0.2915
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0266 0.1058
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0072
Schistosoma mansoni nephrin 0.0055 0.0444 0.0438
Plasmodium falciparum importin beta, putative 0.003 0.0172 0.3051
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0266 0.0748
Loa Loa (eye worm) cytochrome P450 family protein 0.0137 0.1311 0.3769
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0025 0.0056
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.1879 0.2698
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0032 0.0201 0.067
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0552 0.157
Schistosoma mansoni protein kinase 0.0065 0.0552 0.0546
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0357 0.0512
Loa Loa (eye worm) hypothetical protein 0.0051 0.0404 0.1161
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0061 0.0509 0.1463
Trypanosoma brucei ISWI complex protein 0.0018 0.0044 0.0132
Entamoeba histolytica serine/threonine protein kinase, putative 0.0288 0.2919 0.8377
Schistosoma mansoni neuropeptide receptor 0.0188 0.1857 0.1853
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0465 0.1322
Schistosoma mansoni cell adhesion molecule 0.0056 0.0458 0.0452
Loa Loa (eye worm) hypothetical protein 0.005 0.0393 0.1128
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0307 0.1032
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0288 0.2919 1
Echinococcus granulosus twitchin 0.0057 0.0469 0.0673
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0032 0.0201 0.1202
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0549 0.0543
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0016 0.0045
Echinococcus granulosus importin subunit beta 1 0.003 0.0172 0.0248
Schistosoma mansoni tyrosine kinase 0.0016 0.0023 0.0017
Echinococcus granulosus lamin 0.0028 0.0152 0.0218
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0372 0.1256
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0549 0.1577
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0213 0.0845
Brugia malayi Importin beta-1 subunit 0.003 0.0172 0.048
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0032 0.0201 0.0794
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0048 0.0372 0.2254
Entamoeba histolytica Ran family GTPase 0.0022 0.0089 0.024
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0006 0.0017
Echinococcus multilocularis zinc finger protein 0.0022 0.0096 0.0139
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0307 0.0881
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0025 0.0056
Loa Loa (eye worm) beta-lactamase 0.0038 0.0266 0.0764
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0361 0.2189
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0288 0.2919 0.4192
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0404 0.0398
Mycobacterium tuberculosis Conserved protein 0.0038 0.0266 0.1058
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0032 0.0201 0.0794
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0549 0.0788
Onchocerca volvulus 0.0038 0.0266 0.0889
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.005 0.0128
Brugia malayi Cytochrome P450 family protein 0.0048 0.0372 0.1053
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0552 0.157
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0307 0.5507
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0266 0.1603
Schistosoma mansoni hypothetical protein 0.0018 0.005 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0032 0.0201 0.0794
Echinococcus granulosus lamin dm0 0.0028 0.0152 0.0218
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0307 0.0865
Brugia malayi Immunoglobulin I-set domain containing protein 0.0341 0.348 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0393 0.1128
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0672
Brugia malayi Cytochrome P450 family protein 0.0032 0.0201 0.0562
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.2919 0.8377
Plasmodium vivax SET domain protein, putative 0.0032 0.0196 0.3487
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0032 0.0201 0.0794
Echinococcus multilocularis roundabout 2 0.0061 0.0509 0.0731
Leishmania major hypothetical protein, conserved 0.0038 0.0266 0.0893
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0361 0.2189
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0307 0.0865
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0152 0.0437
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.3484 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0361 0.2189
Loa Loa (eye worm) hypothetical protein 0.0047 0.0361 0.1038
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0266 0.0748
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0357 0.1025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0266 0.0764
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0089 0.0287
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0361 0.1023
Brugia malayi Glycosyl hydrolases family 31 protein 0.019 0.1879 0.5393
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0307 0.0866
Loa Loa (eye worm) AUR protein kinase 0.0065 0.0552 0.1586
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0025 0.0056
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0025 0.0066
Brugia malayi serine/threonine protein kinase 6 0.0065 0.0552 0.1572
Trypanosoma brucei glucosidase, putative 0.0042 0.0307 0.1032
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0266 0.1058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0465 0.1337
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0025 0.0056
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0266 0.0764
Loa Loa (eye worm) hypothetical protein 0.0038 0.0266 0.0764
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0032 0.0201 0.067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0404 0.0398
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0361 0.2189
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0668 0.6964 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0357 0.101
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0172 0.0572
Leishmania major hypothetical protein, conserved 0.0018 0.0044 0.0132
Loa Loa (eye worm) hypothetical protein 0.005 0.0393 0.1128
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.005 0.0072
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0167 0.1629 0.6604
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0361 0.122
Trypanosoma cruzi aurora B kinase, putative 0.0065 0.0552 0.1875
Loa Loa (eye worm) hypothetical protein 0.005 0.0393 0.1128
Echinococcus granulosus neuroglian 0.0055 0.0444 0.0637
Echinococcus multilocularis GPCR, family 2 0.0018 0.005 0.0072
Brugia malayi serine/threonine-protein kinase 6 0.0065 0.0552 0.1572
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0266 0.0382
Brugia malayi Bromodomain containing protein 0.0044 0.0324 0.0917
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.3213 0.9235
Loa Loa (eye worm) hypothetical protein 0.005 0.0393 0.1128
Schistosoma mansoni hypothetical protein 0.0194 0.1921 0.1917
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0089 0.0128
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0056 0.0458 0.0658
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0196 0.0191
Brugia malayi beta-lactamase 0.0038 0.0266 0.0749
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0109 0.0314
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0032 0.0201 0.0794
Giardia lamblia Kinase, PLK 0.0288 0.2919 0.8337
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.005 0.0144
Brugia malayi Latrophilin receptor protein 2 0.0018 0.005 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0025 0.0056
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0393 0.1113
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0025 0.0066
Schistosoma mansoni intermediate filament proteins 0.0028 0.0152 0.0146
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0032 0.0201 0.1202
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0025 0.0056
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0016 0.0028
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0307 0.0865
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0196 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.3484 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0549 0.0543
Trypanosoma brucei aurora B kinase 0.0065 0.0552 0.1875
Schistosoma mansoni importin beta-1 0.003 0.0172 0.0167
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0213 0.0845
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0585 0.084
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0266 0.1058
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0361 0.2189
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0266 0.026
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.2919 0.8377
Loa Loa (eye worm) hypothetical protein 0.0038 0.0266 0.0764
Trypanosoma brucei cytochrome P450, putative 0.0048 0.0372 0.1256
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0065 0.0552 0.157
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0025 0.0066
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0234 0.4178
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0266 0.1058
Schistosoma mansoni hypothetical protein 0.0018 0.005 0.0044
Brugia malayi beta-lactamase family protein 0.0038 0.0266 0.0749
Loa Loa (eye worm) hypothetical protein 0.0027 0.0147 0.0422
Giardia lamblia Aurora kinase 0.0065 0.0552 0.1363
Onchocerca volvulus Serine\/threonine kinase homolog 0.0288 0.2919 0.996
Echinococcus granulosus Immunoglobulin 0.005 0.0393 0.0564
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0549 0.1577
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0307 0.0865
Loa Loa (eye worm) hypothetical protein 0.0049 0.0377 0.1085
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0032 0.0201 0.1202
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0083
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0032 0.0201 0.0794
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0032 0.0201 0.0794
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0032 0.0201 0.1202
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0065 0.0552 0.0793
Entamoeba histolytica hypothetical protein 0.004 0.0281 0.0792
Leishmania major cytochrome p450-like protein 0.0048 0.0372 0.1256
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0361 0.1446
Leishmania major GTP-binding protein, putative 0.0022 0.0089 0.0287
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0032 0.0201 0.0794
Loa Loa (eye worm) hypothetical protein 0.0038 0.0266 0.0764
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0032 0.0201 0.1202
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0307 0.0865
Treponema pallidum fructose-bisphosphate aldolase 0.0341 0.3484 0.5
Echinococcus multilocularis aurora kinase A 0.0065 0.0552 0.0793
Mycobacterium ulcerans hypothetical protein 0.0047 0.0361 0.2189
Echinococcus granulosus tar DNA binding protein 0.0065 0.0549 0.0788
Loa Loa (eye worm) hypothetical protein 0.0038 0.0266 0.0764
Schistosoma mansoni hypothetical protein 0.0018 0.005 0.0044
Mycobacterium leprae Probable lipase LipE 0.0038 0.0266 0.1603
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.2919 0.8377
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0549 0.1563
Onchocerca volvulus 0.0038 0.0266 0.0889
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0307 0.0865
Echinococcus multilocularis lamin 0.0028 0.0152 0.0218
Echinococcus multilocularis musashi 0.0028 0.0152 0.0218
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0032 0.0201 0.0794
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0549 0.0543
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0025 0.0056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.3484 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0357 0.0512
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0032 0.0201 0.1202
Brugia malayi Pre-SET motif family protein 0.0222 0.2216 0.6361
Brugia malayi intermediate filament protein 0.0028 0.0152 0.0421
Loa Loa (eye worm) cytochrome P450 0.0032 0.0201 0.0578
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0266 0.1058
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0281 0.0404
Loa Loa (eye worm) hypothetical protein 0.0081 0.0719 0.2067
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0032 0.0201 0.1202
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.2216 0.6367
Schistosoma mansoni hypothetical protein 0.0018 0.005 0.0044
Echinococcus granulosus roundabout 2 0.0061 0.0509 0.0731
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0032 0.0201 0.1202
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.2919 0.8377
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0361 0.1023
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0361 0.2189
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0372 0.1068
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0668 0.6964 1
Schistosoma mansoni zinc finger protein 0.0022 0.0096 0.0091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0357 0.0512
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0066 0.0094
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0032 0.0201 0.0794
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.3484 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0025 0.0066
Leishmania major cytochrome p450-like protein 0.0032 0.0201 0.067
Loa Loa (eye worm) hypothetical protein 0.0047 0.0361 0.1038
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0266 0.0749
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.3484 1
Entamoeba histolytica hypothetical protein 0.004 0.0281 0.0792
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0025 0.0056
Echinococcus granulosus GPCR family 2 0.0018 0.005 0.0072
Leishmania major cytochrome p450-like protein 0.0032 0.0201 0.067
Schistosoma mansoni cytochrome P450 0.0032 0.0201 0.0195
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0672
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.005 0.0072
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0006 0.0008
Brugia malayi Cytochrome P450 family protein 0.0137 0.1311 0.3759
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0133 0.019
Echinococcus granulosus zinc finger protein 0.0022 0.0096 0.0139
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.2464 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0066 0.0094
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0273 0.0769
Schistosoma mansoni alpha-glucosidase 0.0164 0.1598 0.1593
Brugia malayi Cytochrome P450 family protein 0.0048 0.0372 0.1053
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0234 0.1405
Entamoeba histolytica protein kinase, putative 0.0065 0.0552 0.157
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0361 0.2189
Schistosoma mansoni zinc finger protein 0.0018 0.0044 0.0039
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0288 0.2919 0.8389
Trypanosoma cruzi ISWI complex protein 0.0018 0.0044 0.0132
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0266 0.0382
Toxoplasma gondii cytochrome p450 superfamily protein 0.0032 0.0201 0.3573
Trypanosoma brucei polo-like protein kinase 0.0288 0.2919 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10 nM Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting ChEMBL. 21802951

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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