Detailed information for compound 1044040

Basic information

Technical information
  • TDR Targets ID: 1044040
  • Name: [4-(3-methoxy-4-methylbenzoyl)phenyl]-(4-meth oxy-3-methylphenyl)methanone
  • MW: 374.429 | Formula: C24H22O4
  • H donors: 0 H acceptors: 2 LogP: 5.28 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C)C(=O)c1ccc(cc1)C(=O)c1ccc(c(c1)OC)C
  • InChi: 1S/C24H22O4/c1-15-5-6-20(14-22(15)28-4)24(26)18-9-7-17(8-10-18)23(25)19-11-12-21(27-3)16(2)13-19/h5-14H,1-4H3
  • InChiKey: MMGSSDSHZMYJSY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [4-(3-methoxy-4-methyl-benzoyl)phenyl]-(4-methoxy-3-methyl-phenyl)methanone
  • (4-methoxy-3-methylphenyl)-[4-[(3-methoxy-4-methylphenyl)-oxomethyl]phenyl]methanone
  • (4-methoxy-3-methyl-phenyl)-[4-(3-methoxy-4-methyl-phenyl)carbonylphenyl]methanone
  • [4-(3-Methoxy-4-methyl-benzoyl)-phenyl]-(4-methoxy-3-methyl-phenyl)-methanone
  • Oprea1_370143
  • ZINC00797346
  • BAS 00316110
  • Oprea1_229328

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0425 0.0459 0.063
Echinococcus granulosus casein kinase I gamma 0.0287 0.0213 0.0314
Brugia malayi Protein kinase domain containing protein 0.1531 0.2433 0.3342
Trichomonas vaginalis CMGC family protein kinase 0.0367 0.0355 0.2932
Trypanosoma brucei protein kinase, putative 0.0185 0.0031 0.0028
Giardia lamblia Kinase, AGC PKA 0.0232 0.0115 0.0849
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0254 0.0154 0.0226
Loa Loa (eye worm) casein kinase 0.0175 0.0012 0.0017
Giardia lamblia Kinase, NEK 0.0213 0.008 0.0541
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0215 0.0085 0.0584
Trypanosoma cruzi aurora B kinase, putative 0.0446 0.0496 0.1002
Schistosoma mansoni tyrosine kinase 0.1385 0.2173 0.6109
Schistosoma mansoni tyrosine kinase 0.0734 0.1012 0.2844
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0483 0.0563 0.1142
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0989 0.1466 0.2155
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.1794 0.2903 0.3987
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0232 0.0115 0.0931
Brugia malayi protein C17H12.11 0.0425 0.0459 0.063
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0768 0.1071 0.2207
Brugia malayi Protein kinase domain containing protein 0.0407 0.0426 0.0586
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.06 0.0772 0.1135
Loa Loa (eye worm) hypothetical protein 0.0447 0.0498 0.0684
Brugia malayi ephrin receptor 1 precursor 0.0187 0.0033 0.0046
Brugia malayi Cam kinase protein 1 0.0365 0.0352 0.0483
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0507 0.0606 0.1233
Loa Loa (eye worm) hypothetical protein 0.0254 0.0154 0.0211
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0538 0.0661 0.0971
Echinococcus granulosus tyrosine protein kinase otk 0.0191 0.0041 0.006
Trichomonas vaginalis AGC family protein kinase 0.0446 0.0496 0.4157
Echinococcus multilocularis expressed conserved protein 0.0211 0.0077 0.0077
Trichomonas vaginalis STE family protein kinase 0.0778 0.1089 0.9308
Giardia lamblia Kinase, NEK 0.0213 0.008 0.0541
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.0199 0.0559
Echinococcus granulosus dual specificity 0.0728 0.1001 0.1471
Echinococcus granulosus TGF beta receptor type 1 0.0611 0.0791 0.1162
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.1276 0.1978 0.2908
Schistosoma mansoni roundabout 0.0191 0.0041 0.0115
Echinococcus multilocularis roundabout 2 0.0214 0.0083 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.0213 0.0599
Echinococcus granulosus hemicentin 1 0.0191 0.0041 0.006
Echinococcus multilocularis casein kinase ii subunit alpha 0.0178 0.0018 0.0018
Trypanosoma brucei SNF1-related protein kinases, putative 0.0279 0.0199 0.038
Giardia lamblia Kinase, NEK 0.0213 0.008 0.0541
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Brugia malayi Immunoglobulin I-set domain containing protein 0.0191 0.0041 0.0056
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0399 0.0413 0.1161
Echinococcus granulosus serine:threonine protein kinase TAO1 0.1794 0.2903 0.4268
Plasmodium vivax calcium-dependent protein kinase, putative 0.0365 0.0352 0.2967
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.1566 0.2496 0.2496
Loa Loa (eye worm) hypothetical protein 0.0193 0.0044 0.0061
Echinococcus granulosus epidermal growth factor receptor 0.0734 0.1012 0.1487
Schistosoma mansoni serine/threonine protein kinase 0.0273 0.0188 0.0528
Loa Loa (eye worm) hypothetical protein 0.1146 0.1746 0.2398
Loa Loa (eye worm) hypothetical protein 0.0448 0.0501 0.0688
Loa Loa (eye worm) hypothetical protein 0.0191 0.0041 0.0056
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0211 0.0077 0.0518
Brugia malayi Stress-activated protein kinase jnk-1 0.1941 0.3166 0.4348
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0768 0.1071 0.2207
Echinococcus multilocularis growth factor receptor bound protein 2 0.0242 0.0132 0.0132
Echinococcus granulosus STE20 serine:threonine protein kinase 0.056 0.0699 0.1028
Loa Loa (eye worm) hypothetical protein 0.0191 0.0041 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0407 0.0426 0.1199
Echinococcus multilocularis neuroglian 0.0214 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0296 0.0228 0.0313
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0659 0.0878 0.0878
Brugia malayi Protein kinase domain containing protein 0.0509 0.0609 0.0837
Echinococcus granulosus tyrosine protein kinase Src42A 0.0659 0.0878 0.129
Schistosoma mansoni tyrosine kinase 0.1037 0.1552 0.4362
Schistosoma mansoni serine/threonine protein kinase 0.1206 0.1854 0.5213
Loa Loa (eye worm) hypothetical protein 0.0662 0.0882 0.1211
Trypanosoma cruzi casein kinase, putative 0.0449 0.0501 0.1013
Echinococcus granulosus cyclin dependent kinase 5 0.0367 0.0355 0.0522
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0251 0.0148 0.0218
Echinococcus granulosus serine:threonine protein kinase N2 0.0893 0.1295 0.1904
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0596 0.0764 0.0764
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0211 0.0077 0.0077
Onchocerca volvulus 0.0709 0.0965 0.1326
Schistosoma mansoni protein kinase 0.0268 0.0178 0.05
Leishmania major protein kinase A catalytic subunit isoform 1 0.0507 0.0606 0.1233
Brugia malayi Immunoglobulin I-set domain containing protein 0.1165 0.1779 0.2444
Schistosoma mansoni serine/threonine protein kinase 0.1531 0.2433 0.6841
Toxoplasma gondii casein kinase I 0.0449 0.0501 0.4202
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0407 0.0426 0.0627
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0407 0.0426 0.0426
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0507 0.0606 0.0606
Schistosoma mansoni ephrin receptor 0.0219 0.0092 0.0258
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.0085 0.0584
Echinococcus granulosus tyrosine kinase 0.0556 0.0693 0.1018
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0728 0.1001 0.2059
Loa Loa (eye worm) TK protein kinase 0.0451 0.0506 0.0695
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0221 0.0095 0.014
Brugia malayi serine/threonine-protein kinase 6 0.0446 0.0496 0.0681
Entamoeba histolytica protein kinase domain containing protein 0.0822 0.1168 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0214 0.0083 0.0114
Brugia malayi Tyrosine-protein kinase abl-1 0.0758 0.1054 0.1448
Trichomonas vaginalis AGC family protein kinase 0.0183 0.0027 0.0084
Plasmodium falciparum calcium-dependent protein kinase 2 0.0365 0.0352 0.2903
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0258 0.016 0.016
Echinococcus multilocularis calcium dependent protein kinase 0.0252 0.0151 0.0151
Echinococcus multilocularis casein kinase I alpha 0.0449 0.0501 0.0501
Trichomonas vaginalis AGC family protein kinase 0.043 0.0468 0.3916
Echinococcus granulosus dual specificity 0.0215 0.0085 0.0125
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0851 0.1219 0.1674
Trichomonas vaginalis CAMK family protein kinase 0.0274 0.019 0.1498
Entamoeba histolytica protein kinase domain containing protein 0.0822 0.1168 1
Brugia malayi Fes/CIP4 homology domain containing protein 0.0602 0.0775 0.1065
Onchocerca volvulus 0.0186 0.0032 0.0044
Echinococcus granulosus cyclin dependent kinase 0.0367 0.0355 0.0522
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0463 0.0526 0.0723
Echinococcus multilocularis TGF beta receptor type 1 0.0611 0.0791 0.0791
Entamoeba histolytica protein kinase, putative 0.0446 0.0496 0.4157
Loa Loa (eye worm) AGC/PKA protein kinase 0.0507 0.0606 0.0833
Loa Loa (eye worm) CAMK protein kinase 0.0264 0.0172 0.0236
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0778 0.1089 0.1495
Schistosoma mansoni serine/threonine protein kinase 0.0242 0.0133 0.0375
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0254 0.0154 0.0211
Toxoplasma gondii aurora kinase 0.0446 0.0496 0.4157
Giardia lamblia Kinase, PLK 0.0251 0.0148 0.1134
Loa Loa (eye worm) TK/EPH protein kinase 0.0236 0.0122 0.0168
Loa Loa (eye worm) TK/FER protein kinase 0.0296 0.0228 0.0313
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0768 0.1071 0.2207
Echinococcus granulosus N chimaerin 0.0254 0.0154 0.0226
Brugia malayi Protein kinase domain containing protein 0.0233 0.0116 0.0159
Leishmania major protein kinase, putative 0.0365 0.0352 0.07
Schistosoma mansoni serine/threonine protein kinase 0.1151 0.1754 0.4932
Entamoeba histolytica protein kinase, putative 0.0366 0.0354 0.2922
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.1276 0.1978 0.1978
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0347 0.0319 0.0469
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0242 0.0132 0.0182
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0365 0.0352 0.0352
Echinococcus granulosus tyrosine protein kinase shark 0.0502 0.0597 0.0878
Brugia malayi Protein kinase domain containing protein 0.19 0.3092 0.4247
Echinococcus granulosus epidermal growth factor receptor 0.06 0.0772 0.1135
Onchocerca volvulus 0.0192 0.0042 0.0058
Echinococcus granulosus casein kinase I alpha 0.0449 0.0501 0.0737
Brugia malayi P38 map kinase family protein 2 0.2852 0.4791 0.658
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0425 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0483 0.0563 0.0773
Brugia malayi Protein kinase domain containing protein 0.1151 0.1754 0.2409
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.113 0.1717 0.2358
Trichomonas vaginalis STE family protein kinase 0.0778 0.1089 0.9308
Schistosoma mansoni protein kinase 0.0646 0.0854 0.24
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1531 0.2433 0.2433
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1689 0.2716 0.2716
Echinococcus granulosus casein kinase I alpha 0.0449 0.0501 0.0737
Schistosoma mansoni serine/threonine protein kinase 0.0728 0.1001 0.2813
Echinococcus multilocularis aurora kinase A 0.0446 0.0496 0.0496
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.1037 0.1552 0.1552
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.0085 0.0584
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.024 0.0128 0.0128
Echinococcus multilocularis Immunoglobulin 0.0425 0.0459 0.0459
Schistosoma mansoni serine/threonine-protein kinase 0.0262 0.0169 0.0474
Brugia malayi Variant SH3 domain containing protein 0.0242 0.0132 0.0182
Onchocerca volvulus 0.0822 0.1168 0.1605
Echinococcus multilocularis mitogen activated protein kinase 11 0.2852 0.4791 0.4791
Echinococcus multilocularis cyclin dependent kinase 9 0.027 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0425 0.0459 0.063
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0507 0.0606 0.0891
Echinococcus granulosus tyrosine protein kinase ABL1 0.1523 0.242 0.3558
Brugia malayi Tyrosine-protein kinase abl-1 0.0869 0.1251 0.1718
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0232 0.0115 0.0115
Entamoeba histolytica protein kinase, putative 0.0728 0.1001 0.8542
Echinococcus granulosus casein kinase ii subunit alpha 0.0178 0.0018 0.0026
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1325 0.2065 0.2065
Echinococcus multilocularis rho associated protein kinase 0.0687 0.0927 0.0927
Loa Loa (eye worm) TK protein kinase 0.0556 0.0693 0.0951
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0344 0.0314 0.0432
Entamoeba histolytica protein kinase, putative 0.0266 0.0176 0.1377
Loa Loa (eye worm) hypothetical protein 0.0563 0.0705 0.0969
Schistosoma mansoni tyrosine kinase 0.0659 0.0878 0.2467
Loa Loa (eye worm) TK/FER protein kinase 0.0296 0.0228 0.0313
Brugia malayi putative serine/threonine kinase SADA gamma 0.0279 0.0199 0.0273
Echinococcus multilocularis casein kinase I delta 0.0449 0.0501 0.0501
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0294 0.0225 0.1804
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0488 0.0571 0.084
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0851 0.1219 0.1219
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0242 0.0132 0.0182
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0425 0.0459 0.1289
Loa Loa (eye worm) hypothetical protein 0.0365 0.0352 0.0483
Schistosoma mansoni protein kinase 0.027 0.0182 0.0513
Echinococcus multilocularis serine:threonine protein kinase N2 0.13 0.2021 0.2021
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0148 0.1134
Echinococcus granulosus tyrosine protein kinase Src42A 0.041 0.0432 0.0636
Schistosoma mansoni protein kinase 0.1566 0.2496 0.7018
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.027 0.0182 0.1431
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0258 0.016 0.016
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.2852 0.4791 0.658
Echinococcus multilocularis serine:threonine protein kinase 3 0.033 0.0289 0.0289
Echinococcus granulosus activated cdc42 kinase 1 0.1146 0.1746 0.2567
Entamoeba histolytica protein kinase, putative 0.0728 0.1001 0.8542
Loa Loa (eye worm) TK protein kinase 0.1165 0.1779 0.2444
Giardia lamblia Kinase, CAMK CAMKL 0.0303 0.0241 0.194
Echinococcus granulosus cyclin dependent kinase 1 0.0367 0.0355 0.0522
Brugia malayi cell division control protein 2 homolog 0.0367 0.0355 0.0488
Entamoeba histolytica hypothetical protein 0.0728 0.1001 0.8542
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.113 0.1717 0.2358
Trichomonas vaginalis AGC family protein kinase 0.0213 0.008 0.0541
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0537 0.066 0.0906
Echinococcus multilocularis tyrosine protein kinase Srms 0.0556 0.0693 0.0693
Giardia lamblia Kinase, CMGC CDK 0.0367 0.0355 0.2932
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1531 0.2433 0.3342
Schistosoma mansoni titin 0.0191 0.0041 0.0115
Echinococcus granulosus dual specificity 0.0215 0.0085 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.0083 0.0234
Leishmania major protein kinase, putative 0.0446 0.0496 0.1002
Echinococcus multilocularis fibroblast growth factor receptor 4 0.1037 0.1552 0.1552
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0191 0.0041 0.0041
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0449 0.0501 0.0688
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0449 0.0501 0.0688
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0183 0.0027 0.0037
Plasmodium vivax glycogen synthase kinase 3, putative 0.0822 0.1168 1
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0279 0.0199 0.0199
Brugia malayi protein kinase C3,putative 0.0309 0.0251 0.0345
Echinococcus granulosus Protein kinase C brain isozyme 0.0562 0.0704 0.1035
Echinococcus granulosus activin receptor type 0.2813 0.4723 0.6944
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0214 0.0083 0.0114
Echinococcus granulosus roundabout 2 0.0214 0.0083 0.0122
Brugia malayi Protein kinase domain containing protein 0.0728 0.1001 0.1374
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0676 0.0907 0.1245
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0449 0.0501 0.1013
Schistosoma mansoni serine/threonine protein kinase 0.0768 0.1071 0.3011
Schistosoma mansoni serine/threonine protein kinase 0.0264 0.0172 0.0482
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.1201 0.1845 0.2534
Loa Loa (eye worm) AGC/PKN protein kinase 0.13 0.2021 0.2775
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0262 0.0169 0.0316
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Schistosoma mansoni protein kinase 0.0778 0.1089 0.3061
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0191 0.0041 0.0056
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.033 0.0289 0.0396
Trypanosoma cruzi cdc2-related kinase 1 0.0367 0.0355 0.0707
Schistosoma mansoni tyrosine kinase 0.0399 0.0413 0.1161
Trypanosoma brucei rac serine-threonine kinase, putative 0.0556 0.0694 0.1416
Plasmodium falciparum glycogen synthase kinase 3 0.0822 0.1168 1
Loa Loa (eye worm) gastrulation defective protein 1 0.1038 0.1553 0.2133
Echinococcus multilocularis protein kinase c iota type 0.0603 0.0776 0.0776
Echinococcus multilocularis slit 2 protein 0.0188 0.0036 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0128 0.0361
Schistosoma mansoni serine/threonine protein kinase 0.0242 0.0133 0.0375
Trypanosoma cruzi cdc2-related kinase 3 0.0367 0.0355 0.0707
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1531 0.2433 0.3342
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0242 0.0132 0.0372
Echinococcus multilocularis serine:threonine protein kinase 38 0.0407 0.0426 0.0426
Echinococcus granulosus mitogen activated protein kinase 14 0.2852 0.4791 0.7044
Schistosoma mansoni tyrosine kinase 0.0443 0.0491 0.138
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0507 0.0606 0.5158
Entamoeba histolytica protein kinase, putative 0.0407 0.0426 0.3552
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0659 0.0878 0.129
Brugia malayi Protein kinase domain containing protein 0.0662 0.0882 0.1211
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0277 0.0195 0.0195
Loa Loa (eye worm) SRC-1 0.0659 0.0878 0.1205
Trichomonas vaginalis CAMK family protein kinase 0.0365 0.0352 0.2903
Entamoeba histolytica protein kinase, putative 0.0417 0.0446 0.3719
Loa Loa (eye worm) TK/KIN16 protein kinase 0.2392 0.397 0.5453
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1531 0.2433 0.3342
Echinococcus multilocularis roundabout 2 0.0214 0.0083 0.0083
Entamoeba histolytica protein kinase, putative 0.0266 0.0176 0.1377
Giardia lamblia Kinase, CMGC GSK 0.0822 0.1168 1
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0347 0.032 0.0439
Echinococcus granulosus tyrosine protein kinase HCK 0.0417 0.0446 0.0655
Plasmodium falciparum protein serine/threonine kinase-1 0.0768 0.1071 0.9152
Schistosoma mansoni serine/threonine protein kinase 0.0365 0.0352 0.0989
Echinococcus multilocularis peroxidasin 0.0193 0.0044 0.0044
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0277 0.0195 0.0287
Schistosoma mansoni serine/threonine protein kinase 0.0407 0.0426 0.1199
Brugia malayi Immunoglobulin I-set domain containing protein 0.0191 0.0041 0.0056
Echinococcus granulosus activated cdc42 kinase 1 0.1146 0.1746 0.2567
Schistosoma mansoni serine/threonine protein kinase 0.0449 0.0501 0.1409
Loa Loa (eye worm) TK/ROR protein kinase 0.0285 0.0209 0.0287
Trichomonas vaginalis STE family protein kinase 0.0258 0.016 0.1239
Schistosoma mansoni serine/threonine protein kinase 0.1941 0.3166 0.8901
Echinococcus granulosus phosphorylase kinase gamma subunit 0.024 0.0128 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Brugia malayi Hr1 repeat family protein 0.13 0.2021 0.2775
Schistosoma mansoni nephrin 0.0576 0.0729 0.2049
Entamoeba histolytica protein kinase domain containing protein 0.0215 0.0085 0.0584
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0129 0.0363
Schistosoma mansoni protein kinase 0.0258 0.016 0.0451
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1531 0.2433 0.3578
Echinococcus multilocularis casein kinase I alpha 0.0449 0.0501 0.0501
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0483 0.0563 0.0827
Entamoeba histolytica serine/threonine protein kinase, putative 0.0251 0.0148 0.1134
Schistosoma mansoni serine/threonine kinase 0.0345 0.0317 0.0891
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0365 0.0352 0.0483
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0285 0.0209 0.0209
Entamoeba histolytica protein kinase domain containing protein 0.0277 0.0195 0.154
Loa Loa (eye worm) hypothetical protein 0.0191 0.0041 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0148 0.1134
Schistosoma mansoni serine/threonine protein kinase 0.0344 0.0314 0.0884
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0695 0.0941 0.1292
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0912 0.1329 0.1329
Echinococcus multilocularis dual specificity protein kinase clk2 0.0768 0.1071 0.1071
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.1566 0.2496 0.367
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0659 0.0878 0.0878
Entamoeba histolytica protein kinase, putative 0.0526 0.064 0.541
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0507 0.0606 0.0891
Loa Loa (eye worm) hypothetical protein 0.0432 0.0472 0.0648
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0178 0.0018 0.009
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0507 0.0606 0.1233
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0446 0.0496 0.4157
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0362 0.0347 0.0511
Schistosoma mansoni protein kinase 0.0178 0.0018 0.005
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0214 0.0083 0.0114
Trypanosoma brucei aurora B kinase 0.0446 0.0496 0.1002
Echinococcus multilocularis epidermal growth factor receptor 0.0734 0.1012 0.1012
Echinococcus multilocularis twitchin 0.024 0.0129 0.0129
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0246 0.014 0.0193
Echinococcus granulosus serine/threonine protein kinase 0.0262 0.0169 0.0248
Echinococcus multilocularis tyrosine protein kinase Abl 0.0869 0.1251 0.1251
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0791 0.1113 0.1529
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.0148 0.0417
Schistosoma mansoni cell adhesion molecule 0.0191 0.0041 0.0115
Schistosoma mansoni cell adhesion molecule 0.0214 0.0083 0.0234
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0148 0.1134
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0192 0.0044 0.0044
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0483 0.0563 0.1142
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0232 0.0115 0.0205
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0279 0.0199 0.038
Entamoeba histolytica protein kinase domain containing protein 0.019 0.004 0.0196
Brugia malayi serine/threonine protein kinase 6 0.0446 0.0496 0.0681
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0728 0.1001 0.2059
Echinococcus granulosus serine:threonine kinase SAD 1 0.0279 0.0199 0.0293
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.0085 0.0239
Echinococcus granulosus protein tyrosine kinase 0.216 0.3557 0.523
Schistosoma mansoni tyrosine kinase 0.0889 0.1287 0.3618
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0215 0.0085 0.0141
Echinococcus granulosus c-Jun N-terminal kinases 0.1941 0.3166 0.4655
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0169 0.0002 0.0002
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0507 0.0606 0.0606
Echinococcus granulosus contactin 0.0214 0.0083 0.0122
Echinococcus granulosus Vam6:Vps39 protein 0.0483 0.0563 0.0827
Echinococcus multilocularis tyrosine protein kinase otk 0.0191 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0233 0.0116 0.0159
Echinococcus granulosus ephrin type A receptor 4 A 0.0219 0.0092 0.0135
Schistosoma mansoni tyrosine kinase 0.0659 0.0878 0.2467
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0303 0.0241 0.2012
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.0085 0.0584
Brugia malayi Protein kinase domain containing protein 0.0347 0.032 0.0439
Schistosoma mansoni serine/threonine-protein kinase 0.0262 0.0169 0.0474
Echinococcus granulosus casein kinase I delta 0.0449 0.0501 0.0737
Onchocerca volvulus 0.0216 0.0087 0.0119
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.1151 0.1754 0.2409
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0659 0.0878 0.0878
Echinococcus multilocularis rac serine:threonine kinase 0.0262 0.0169 0.0169
Plasmodium falciparum casein kinase 1 0.0449 0.0501 0.4202
Brugia malayi C1-like domain containing protein 0.0791 0.1113 0.1529
Entamoeba histolytica PH domain containing protein kinase, putative 0.0262 0.0169 0.1312
Echinococcus granulosus NDR protein kinase 0.0407 0.0426 0.0627
Giardia lamblia Kinase, STE STE20 0.0778 0.1089 0.9308
Loa Loa (eye worm) hypothetical protein 0.0627 0.0819 0.1125
Trypanosoma cruzi cdc2-related kinase 3 0.0367 0.0355 0.0707
Brugia malayi hypothetical protein 0.1794 0.2903 0.3987
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0556 0.0693 0.1018
Brugia malayi Protein kinase c protein 2 0.0268 0.0179 0.0246
Schistosoma mansoni protein kinase 0.0446 0.0496 0.1395
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0768 0.1071 0.9152
Brugia malayi hypothetical protein 0.0448 0.0501 0.0688
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1531 0.2433 0.3342
Loa Loa (eye worm) TK/FER protein kinase 0.0296 0.0228 0.0313
Echinococcus multilocularis cyclin dependent kinase 19 0.1151 0.1754 0.1754
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.014 0.0394
Trichomonas vaginalis AGC family protein kinase 0.0556 0.0694 0.5873
Schistosoma mansoni tyrosine kinase 0.0443 0.0491 0.138
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0327 0.0284 0.039
Entamoeba histolytica protein kinase, putative 0.0556 0.0694 0.5873
Loa Loa (eye worm) hypothetical protein 0.0191 0.0041 0.0056
Leishmania major casein kinase, putative 0.0449 0.0501 0.1013
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0659 0.0878 0.0878
Trypanosoma brucei protein kinase, putative 0.0822 0.1168 0.2411
Toxoplasma gondii histone kinase SNF1, putative 0.0279 0.0199 0.1576
Loa Loa (eye worm) protein kinase domain-containing protein 0.0287 0.0213 0.0293
Schistosoma mansoni kinase 0.0246 0.014 0.0394
Trichomonas vaginalis AGC family protein kinase 0.0556 0.0694 0.5873
Entamoeba histolytica protein kinase domain containing protein 0.0246 0.014 0.1065
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.2852 0.4791 1
Schistosoma mansoni tyrosine kinase 0.0399 0.0413 0.1161
Schistosoma mansoni serine/threonine protein kinase 0.0367 0.0355 0.0998
Brugia malayi Serine/threonine-protein kinase SULU 0.1794 0.2903 0.3987
Brugia malayi Protein kinase domain containing protein 0.0296 0.0228 0.0313
Loa Loa (eye worm) hypothetical protein 0.0615 0.0799 0.1097
Brugia malayi Protein kinase domain containing protein 0.0768 0.1071 0.1471
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0989 0.1466 0.1466
Loa Loa (eye worm) TK/ALK protein kinase 0.2664 0.4456 0.6119
Trichomonas vaginalis AGC family protein kinase 0.0556 0.0694 0.5873
Echinococcus multilocularis casein kinase I delta 0.0449 0.0501 0.0501
Entamoeba histolytica protein kinase, putative 0.0237 0.0123 0.0914
Echinococcus multilocularis titin 0.0264 0.0172 0.0172
Echinococcus multilocularis mitogen activated protein kinase 11 0.2852 0.4791 0.4791
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0728 0.1001 0.1374
Brugia malayi Protein kinase domain containing protein 0.0889 0.1287 0.1767
Plasmodium falciparum NIMA related kinase 1 0.0213 0.008 0.0541
Brugia malayi Protein kinase domain containing protein 0.2184 0.3599 0.4943
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0728 0.1001 0.2059
Trichomonas vaginalis CK1 family protein kinase 0.0449 0.0501 0.4202
Onchocerca volvulus 0.0296 0.0228 0.0313
Brugia malayi Immunoglobulin I-set domain containing protein 0.0214 0.0083 0.0114
Entamoeba histolytica protein kinase, putative 0.0258 0.016 0.1239
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0365 0.0352 0.07
Loa Loa (eye worm) AGC/PKA protein kinase 0.0507 0.0606 0.0833
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0296 0.0228 0.1829
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.0083 0.0234
Trichomonas vaginalis CMGC family protein kinase 0.0822 0.1168 1
Schistosoma mansoni growth factor receptor-bound protein 0.0242 0.0132 0.0372
Echinococcus granulosus cyclin dependent kinase 19 0.1151 0.1754 0.2579
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0279 0.0199 0.0273
Loa Loa (eye worm) hypothetical protein 0.0381 0.038 0.0522
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0483 0.0563 0.0563
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0728 0.1001 0.2059
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.0085 0.0584
Echinococcus multilocularis hemicentin 1 0.0191 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0483 0.0563 0.1582
Toxoplasma gondii AGC kinase 0.0507 0.0606 0.5114
Loa Loa (eye worm) TK/FAK protein kinase 0.2184 0.3599 0.4943
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0169 0.0002 0.0002
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0191 0.0041 0.0056
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0367 0.0355 0.0488
Schistosoma mansoni protein kinase 0.1566 0.2496 0.7018
Leishmania major protein kinase A catalytic subunit 0.0507 0.0606 0.1233
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0483 0.0563 0.1582
Loa Loa (eye worm) hypothetical protein 0.0563 0.0705 0.0969
Loa Loa (eye worm) hypothetical protein 0.0488 0.0571 0.0785
Loa Loa (eye worm) TK/FER protein kinase 0.0296 0.0228 0.0313
Trichomonas vaginalis CMGC family protein kinase 0.0822 0.1168 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0655 0.087 0.1195
Schistosoma mansoni cell adhesion molecule 0.0512 0.0614 0.1725
Schistosoma mansoni nck2/grb4 0.0242 0.0132 0.0372
Echinococcus granulosus casein kinase I delta 0.0449 0.0501 0.0737
Trypanosoma cruzi casein kinase, putative 0.0449 0.0501 0.1013
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0044 0.0225
Schistosoma mansoni protein kinase 0.0449 0.0501 0.1409
Loa Loa (eye worm) AUR protein kinase 0.0446 0.0496 0.0681
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0367 0.0355 0.0707
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0507 0.0606 0.0606
Echinococcus granulosus raf serine:threonine protein kinase 0.0273 0.0188 0.0276
Leishmania major protein kinase, putative 0.0768 0.1071 0.2207
Echinococcus multilocularis mitogen activated protein kinase 14 0.2852 0.4791 0.4791
Brugia malayi protein kinase C II. 0.0524 0.0635 0.0872
Echinococcus granulosus calcium dependent protein kinase 0.0252 0.0151 0.0221
Schistosoma mansoni protein kinase 0.027 0.0182 0.0513
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0989 0.1466 0.2013
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.1201 0.1845 0.2534
Leishmania major protein kinase, putative 0.027 0.0182 0.0345
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0214 0.0083 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0044 0.0225
Loa Loa (eye worm) thyroid receptor interactor 0.0602 0.0775 0.1065
Loa Loa (eye worm) hypothetical protein 0.0191 0.0041 0.0056
Trypanosoma brucei protein kinase, putative 0.027 0.0182 0.0345
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0912 0.1329 0.1954
Schistosoma mansoni protein kinase 0.0258 0.016 0.0451
Brugia malayi Casein kinase II, alpha chain 0.0178 0.0018 0.0024
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.027 0.0182 0.0345
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0315 0.0262 0.036
Brugia malayi Egg laying defective protein 4 0.0211 0.0077 0.0106
Echinococcus granulosus cGMP dependent protein kinase 1 0.0211 0.0077 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0768 0.1071 0.3011
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0446 0.0496 0.4157
Schistosoma mansoni serine/threonine kinase 0.0407 0.0426 0.1199
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0169 0.0003 0.0004
Echinococcus multilocularis ephrin type A receptor 4 A 0.0219 0.0092 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0758 0.1054 0.2964
Schistosoma mansoni tyrosine kinase 0.0348 0.0322 0.0904
Schistosoma mansoni neuroglian 0.0214 0.0083 0.0234
Brugia malayi Doublecortin family protein 0.0227 0.0105 0.0145
Loa Loa (eye worm) hypothetical protein 0.0432 0.0472 0.0648
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0148 0.1134
Entamoeba histolytica tyrosin kinase, putative 0.019 0.004 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.13 0.2021 0.5681
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0463 0.0526 0.0774
Trypanosoma brucei casein kinase I, isoform 2 0.0449 0.0501 0.1013
Loa Loa (eye worm) hypothetical protein 0.0296 0.0228 0.0313
Brugia malayi Furin-like cysteine rich region family protein 0.0734 0.1012 0.1389
Schistosoma mansoni serine/threonine protein kinase 0.0562 0.0704 0.1979
Trichomonas vaginalis AGC family protein kinase 0.0507 0.0606 0.5114
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1028 0.1536 0.2109
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0258 0.016 0.0236
Brugia malayi Variant SH3 domain containing protein 0.0169 0.0003 0.0004
Loa Loa (eye worm) AGC/AKT protein kinase 0.0556 0.0694 0.0952
Schistosoma mansoni kinase 0.0314 0.0261 0.0733
Onchocerca volvulus 0.1747 0.2819 0.3871
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0822 0.1168 0.2411
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0251 0.0148 0.0148
Schistosoma mansoni serine/threonine protein kinase 0.0562 0.0704 0.1979
Entamoeba histolytica cell division protein kinase 2, putative 0.039 0.0397 0.3296
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0611 0.0791 0.0791
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0446 0.0496 0.4209
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0758 0.1054 0.1054
Trichomonas vaginalis CAMK family protein kinase 0.0322 0.0275 0.2238
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.3978 0.6801 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.027 0.0182 0.0345
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0507 0.0606 0.1233
Echinococcus granulosus cyclin dependent kinase 9 0.027 0.0182 0.0268
Echinococcus multilocularis tyrosine protein kinase HCK 0.0417 0.0446 0.0446
Schistosoma mansoni serine/threonine protein kinase 0.0543 0.0669 0.1881
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0213 0.008 0.0541
Brugia malayi Protein kinase domain containing protein 0.0344 0.0314 0.0431
Schistosoma mansoni vam6/vps39 related 0.0483 0.0563 0.1582
Echinococcus granulosus fibroblast growth factor receptor 4 0.1037 0.1552 0.2281
Trichomonas vaginalis AGC family protein kinase 0.0556 0.0694 0.5873
Brugia malayi Protein kinase domain containing protein 0.0407 0.0426 0.0586
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0659 0.0878 0.0878
Echinococcus multilocularis tyrosine protein kinase Src42A 0.041 0.0432 0.0432
Plasmodium falciparum protein kinase, putative 0.027 0.0182 0.1431
Loa Loa (eye worm) hypothetical protein 0.0507 0.0606 0.0833
Echinococcus granulosus calcium activated potassium channel 0.0242 0.0133 0.0196
Echinococcus granulosus cGMP dependent protein kinase 0.0211 0.0077 0.0114
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0446 0.0496 0.4157
Echinococcus multilocularis mitogen activated protein kinase 14 0.2852 0.4791 0.4791
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1941 0.3166 0.4348
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1028 0.1536 0.2258
Giardia lamblia Kinase, CK1 Casein kinase 0.0449 0.0501 0.4202
Loa Loa (eye worm) hypothetical protein 0.0425 0.0459 0.063
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.0085 0.0584
Brugia malayi Prion-like- 0.0191 0.0041 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0148 0.1134
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0365 0.0352 0.2967
Echinococcus granulosus protein kinase 0.0646 0.0854 0.1255
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0192 0.0044 0.0064
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0507 0.0606 0.0833
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0279 0.0199 0.038
Loa Loa (eye worm) hypothetical protein 0.0709 0.0965 0.1326
Loa Loa (eye worm) TK/FER protein kinase 0.0296 0.0228 0.0313
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0463 0.0526 0.0526
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0191 0.0041 0.0056
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0851 0.1219 0.1792
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0191 0.0041 0.0115
Echinococcus granulosus insulin receptor 0.0889 0.1287 0.1892
Schistosoma mansoni tyrosine kinase 0.0281 0.0202 0.0569
Schistosoma mansoni serine/threonine protein kinase 0.0211 0.0077 0.0217
Loa Loa (eye worm) TK/FER protein kinase 0.0296 0.0228 0.0313
Echinococcus granulosus rho-associated protein kinase 1 0.0687 0.0927 0.1363
Echinococcus granulosus tyrosine protein kinase Srms 0.069 0.0933 0.1372
Echinococcus multilocularis roundabout 2 0.0639 0.0841 0.0841
Giardia lamblia Kinase, CMGC CDK 0.0367 0.0355 0.2932
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0215 0.0085 0.0117
Echinococcus multilocularis activated cdc42 kinase 1 0.1146 0.1746 0.1746
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0778 0.1089 0.2244
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1523 0.242 0.242
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.1037 0.1552 0.2281
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Echinococcus granulosus serine:threonine protein kinase N2 0.13 0.2021 0.2971
Schistosoma mansoni protein kinase 0.1129 0.1716 0.4824
Onchocerca volvulus 0.0296 0.0228 0.0313
Brugia malayi Protein kinase domain containing protein 0.1689 0.2716 0.3731
Loa Loa (eye worm) hypothetical protein 0.0352 0.0328 0.0451
Schistosoma mansoni adapter molecule crk 0.0242 0.0132 0.0372
Loa Loa (eye worm) hypothetical protein 0.0655 0.087 0.1194
Giardia lamblia Kinase, CMGC CLK 0.0768 0.1071 0.9152
Schistosoma mansoni serine/threonine protein kinase 0.1794 0.2903 0.8161
Brugia malayi RhoGAP domain containing protein 0.0254 0.0154 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.0199 0.0559
Plasmodium vivax unspecified product 0.0178 0.0018 0.009
Plasmodium falciparum protein kinase 5 0.0367 0.0355 0.2932
Brugia malayi Protein kinase domain containing protein 0.0268 0.0178 0.0244
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0395 0.0405 0.0405
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0515 0.062 0.0852
Echinococcus granulosus roundabout 2 0.0639 0.0841 0.1237
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0725 0.0994 0.2046
Echinococcus granulosus peroxidasin 0.0193 0.0044 0.0065
Schistosoma mansoni protein kinase 0.0611 0.0791 0.2223
Schistosoma mansoni serine/threonine protein kinase 0.0211 0.0077 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0524 0.0635 0.1786
Onchocerca volvulus 0.0574 0.0726 0.0997
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1325 0.2065 0.3036
Echinococcus granulosus defective proboscis extension response 0.0425 0.0459 0.0674
Schistosoma mansoni serine/threonine protein kinase 0.0446 0.0496 0.1395
Echinococcus granulosus dual specificity 0.0215 0.0085 0.0125
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0483 0.0563 0.1142
Schistosoma mansoni tyrosine kinase 0.0889 0.1287 0.3618
Echinococcus multilocularis NCK adaptor protein 0.0253 0.0153 0.0153
Trichomonas vaginalis STE family protein kinase 0.0258 0.016 0.1239
Plasmodium vivax protein kinase Crk2 0.0367 0.0355 0.2995
Brugia malayi Variant SH3 domain containing protein 0.0254 0.0154 0.0211
Trypanosoma cruzi polo-like protein kinase, putative 0.0251 0.0148 0.0273
Echinococcus granulosus beta-adrenergic receptor kinase 0.0214 0.0083 0.0122
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0214 0.0083 0.0122
Schistosoma mansoni serine/threonine protein kinase 0.0687 0.0927 0.2607
Echinococcus multilocularis protein tyrosine kinase 0.216 0.3557 0.3557
Schistosoma mansoni nephrin 0.0214 0.0083 0.0234
Onchocerca volvulus Serine\/threonine kinase homolog 0.0251 0.0148 0.0203
Trichomonas vaginalis AGC family protein kinase 0.0446 0.0496 0.4157
Brugia malayi Protein kinase domain containing protein 0.0537 0.066 0.0906
Brugia malayi Immunoglobulin I-set domain containing protein 0.0191 0.0041 0.0056
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0365 0.0352 0.2967
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0285 0.0209 0.0307
Brugia malayi serine/threonine-protein kinase plk-2 0.0251 0.0148 0.0203
Echinococcus granulosus tyrosine kinase 0.0296 0.0228 0.0335
Echinococcus multilocularis insulin receptor 0.0889 0.1287 0.1287
Schistosoma mansoni vesicular amine transporter 0.0425 0.0459 0.1289
Echinococcus granulosus protein kinase shaggy 0.0822 0.1168 0.1718
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0367 0.0355 0.0488
Brugia malayi Protein kinase domain containing protein 0.2665 0.4457 0.6122
Brugia malayi Immunoglobulin I-set domain containing protein 0.0315 0.0264 0.0362
Onchocerca volvulus 0.0296 0.0228 0.0313
Echinococcus multilocularis protein KINase family member (kin 25) 0.0538 0.0661 0.0661
Echinococcus multilocularis calcium activated potassium channel 0.0242 0.0133 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Brugia malayi intracellular kinase 0.0822 0.1168 0.1605
Schistosoma mansoni protein kinase 0.0655 0.087 0.2446
Brugia malayi hypothetical protein 0.0296 0.0228 0.0313
Trichomonas vaginalis AGC family protein kinase 0.0446 0.0496 0.4157
Brugia malayi hypothetical protein 0.0483 0.0563 0.0773
Echinococcus granulosus tyrosine protein kinase Fyn 0.0659 0.0878 0.129
Trichomonas vaginalis CAMK family protein kinase 0.0233 0.0116 0.0851
Entamoeba histolytica protein kinase, putative 0.0822 0.1168 1
Brugia malayi Protein kinase domain containing protein 0.0322 0.0275 0.0378
Echinococcus granulosus tyrosine protein kinase Fyn 0.0659 0.0878 0.129
Trypanosoma brucei cdc2-related kinase 3 0.0367 0.0355 0.0707
Echinococcus multilocularis dual specificity mitogen activated protein 0.0778 0.1089 0.1089
Entamoeba histolytica protein kinase 2, putative 0.0232 0.0115 0.0849
Loa Loa (eye worm) TK/FER protein kinase 0.0296 0.0228 0.0313
Trypanosoma cruzi casein kinase, putative 0.0449 0.0501 0.1013
Entamoeba histolytica p21-activated kinase 0.0287 0.0214 0.1703
Onchocerca volvulus Serine\/threonine kinase homolog 0.024 0.0128 0.0176
Brugia malayi Immunoglobulin I-set domain containing protein 0.0214 0.0083 0.0114
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0215 0.0085 0.0141
Giardia lamblia Kinase, AGC AKT 0.0695 0.0941 0.8025
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0365 0.0352 0.2967
Schistosoma mansoni ephrin receptor 0.0181 0.0024 0.0066
Brugia malayi Protein kinase domain containing protein 0.4247 0.7281 1
Echinococcus granulosus Immunoglobulin 0.0425 0.0459 0.0674
Loa Loa (eye worm) IKK protein kinase 0.4247 0.7281 1
Schistosoma mansoni tyrosine kinase 0.0538 0.0661 0.1858
Brugia malayi SH2 domain containing protein 0.0589 0.0753 0.1034
Plasmodium falciparum calcium-dependent protein kinase 3 0.0365 0.0352 0.2903
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.19 0.3092 0.4247
Brugia malayi Protein kinase domain containing protein 0.0275 0.0192 0.0263
Loa Loa (eye worm) TK protein kinase 0.0417 0.0446 0.0612
Loa Loa (eye worm) hypothetical protein 0.0616 0.0799 0.1098
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0662 0.0882 0.1211
Echinococcus granulosus roundabout 2 0.0214 0.0083 0.0122
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0537 0.066 0.0906
Schistosoma mansoni serine/threonine protein kinase 0.0367 0.0355 0.0998
Trypanosoma cruzi polo-like protein kinase, putative 0.0251 0.0148 0.0273
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0268 0.0178 0.0244
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0232 0.0115 0.017
Entamoeba histolytica protein kinase , putative 0.0446 0.0496 0.4157
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0214 0.0083 0.0083
Onchocerca volvulus 0.0296 0.0228 0.0313
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0279 0.0199 0.038
Giardia lamblia Aurora kinase 0.0446 0.0496 0.4157
Loa Loa (eye worm) hypothetical protein 0.0989 0.1465 0.2012
Echinococcus multilocularis epidermal growth factor receptor 0.06 0.0772 0.0772
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0659 0.0878 0.0878
Schistosoma mansoni serine/threonine protein kinase 0.0385 0.0387 0.1089
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0822 0.1168 0.1605
Loa Loa (eye worm) AUR protein kinase 0.0446 0.0496 0.0681
Echinococcus multilocularis lachesin 0.0191 0.0041 0.0041
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0662 0.0882 0.1211
Schistosoma mansoni serine/threonine protein kinase 0.0242 0.0133 0.0375
Echinococcus granulosus neuroglian 0.0214 0.0083 0.0122
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0768 0.1071 0.2207
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1028 0.1536 0.1536
Schistosoma mansoni serine/threonine protein kinase 0.0507 0.0606 0.1704
Echinococcus multilocularis cyclin dependent kinase 9 0.0246 0.014 0.014
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1028 0.1536 0.2109
Schistosoma mansoni atypical protein kinase C 0.0609 0.0787 0.2212
Echinococcus granulosus serine threonine protein kinase nrc 0.0232 0.0115 0.017
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0211 0.0077 0.0077
Toxoplasma gondii AGC kinase 0.0507 0.0606 0.5114
Echinococcus granulosus casein kinase i 0.0449 0.0501 0.0737
Entamoeba histolytica protein kinase domain containing protein 0.0728 0.1001 0.8542
Echinococcus multilocularis Immunoglobulin 0.0425 0.0459 0.0459
Loa Loa (eye worm) TK/FER protein kinase 0.0589 0.0753 0.1034
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0768 0.1071 0.2207
Brugia malayi bone morphogenetic protein type 1 receptor 0.0655 0.087 0.1195
Entamoeba histolytica protein kinase domain containing protein 0.027 0.0182 0.1431
Echinococcus multilocularis dual specificity 0.0215 0.0085 0.0085
Echinococcus granulosus dual specificity mitogen activated protein 0.0778 0.1089 0.1601
Echinococcus granulosus cyclin dependent kinase 9 0.0246 0.014 0.0206
Brugia malayi Immunoglobulin I-set domain containing protein 0.2392 0.397 0.5453
Echinococcus granulosus c src tyrosine kinase 0.0399 0.0413 0.0607
Echinococcus multilocularis dual specificity 0.0215 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0448 0.0501 0.0688
Echinococcus multilocularis dual specificity 0.0215 0.0085 0.0085
Schistosoma mansoni tyrosine kinase 0.06 0.0772 0.2169
Schistosoma mansoni serine/threonine protein kinase 0.0344 0.0314 0.0884
Giardia lamblia Kinase, CMGC GSK 0.0822 0.1168 1
Onchocerca volvulus Tyrosine kinase homolog 0.2032 0.3327 0.4569
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.0192 0.0539
Brugia malayi map kinase activated protein kinase protein 2 0.0463 0.0526 0.0723
Trypanosoma brucei cdc2-related kinase 1 0.0367 0.0355 0.0707
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0362 0.0347 0.0347
Echinococcus granulosus neuroglian 0.0552 0.0686 0.1009
Brugia malayi Protein kinase domain containing protein 0.0367 0.0355 0.0488
Entamoeba histolytica casein kinase 1, putative 0.0449 0.0501 0.4202
Entamoeba histolytica protein kinase, putative 0.0365 0.0352 0.2903
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.2852 0.4791 1
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0507 0.0606 0.5114
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0596 0.0764 0.1123
Schistosoma mansoni tyrosine kinase 0.1232 0.19 0.5343
Schistosoma mansoni tyrosine kinase 0.0502 0.0597 0.1679
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0365 0.0352 0.0483
Trichomonas vaginalis AGC family protein kinase 0.0556 0.0694 0.5873
Echinococcus granulosus serine:threonine protein kinase 3 0.033 0.0289 0.0424
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0507 0.0606 0.5114
Loa Loa (eye worm) hypothetical protein 0.0661 0.0881 0.121
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0659 0.0878 0.0878
Trichomonas vaginalis AGC family protein kinase 0.0437 0.048 0.4015
Brugia malayi serine/threonine-protein kinase PAK 7 0.14 0.2199 0.3021
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0254 0.0154 0.0433
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0365 0.0352 0.0352
Schistosoma mansoni septate junction protein 0.0191 0.0041 0.0115
Loa Loa (eye worm) hypothetical protein 0.0188 0.0036 0.0049
Brugia malayi Temporarily assigned gene name protein 59 0.0483 0.0563 0.0773
Entamoeba histolytica serine/threonine protein kinase, putative 0.0279 0.0199 0.1576
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0659 0.0878 0.129
Trichomonas vaginalis STE family protein kinase 0.0237 0.0123 0.0914
Echinococcus multilocularis beta adrenergic receptor kinase 0.0214 0.0083 0.0083
Echinococcus multilocularis casein kinase I gamma 0.0287 0.0213 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0507 0.0606 0.1704
Echinococcus multilocularis casein kinase i 0.0449 0.0501 0.0501
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Schistosoma mansoni protein kinase 0.1566 0.2496 0.7018
Entamoeba histolytica protein kinase, putative 0.0215 0.0085 0.0584
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0322 0.0275 0.0378
Schistosoma mansoni serine/threonine protein kinase 0.0277 0.0195 0.0548
Plasmodium falciparum calcium-dependent protein kinase 5 0.0365 0.0352 0.2903
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.2852 0.4791 1
Loa Loa (eye worm) hypothetical protein 0.0483 0.0563 0.0773
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0407 0.0426 0.0426
Echinococcus granulosus dual specificity testis-specific protein kinase 0.027 0.0182 0.0268
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0365 0.0352 0.0517
Schistosoma mansoni protein kinase C mu 0.0791 0.1113 0.313
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.0085 0.0584
Echinococcus multilocularis neuroglian 0.0552 0.0686 0.0686
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0562 0.0704 0.0704
Echinococcus granulosus cGMP dependent protein kinase 1 0.0211 0.0077 0.0114
Entamoeba histolytica PH domain containing protein kinase, putative 0.0537 0.0659 0.5577
Schistosoma mansoni tyrosine kinase 0.0364 0.035 0.0985
Brugia malayi SRC-1 0.0659 0.0878 0.1205
Leishmania major protein kinase, putative 0.0768 0.1071 0.2207
Onchocerca volvulus 0.0687 0.0927 0.1273
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Loa Loa (eye worm) hypothetical protein 0.0546 0.0675 0.0926
Echinococcus granulosus dual specificity protein kinase clk2 0.0768 0.1071 0.1575
Trichomonas vaginalis STE family protein kinase 0.0778 0.1089 0.9308
Echinococcus multilocularis serine:threonine protein kinase 0.0233 0.0116 0.0116
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0365 0.0352 0.0352
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0251 0.0148 0.1137
Loa Loa (eye worm) hypothetical protein 0.0952 0.1401 0.1924
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0579 0.0733 0.1007
Loa Loa (eye worm) hypothetical protein 0.0546 0.0675 0.0926
Onchocerca volvulus 0.0336 0.03 0.0412
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0822 0.1168 0.3285
Loa Loa (eye worm) TK/ABL protein kinase 0.1523 0.242 0.3323
Giardia lamblia Kinase, AGC PKA 0.0507 0.0606 0.5114
Echinococcus granulosus growth factor receptor bound protein 2 0.0253 0.0153 0.0225
Brugia malayi Protein kinase domain containing protein 0.0296 0.0228 0.0313
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0851 0.1219 0.1674
Trichomonas vaginalis STE family protein kinase 0.0258 0.016 0.1239
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.2852 0.4791 1
Echinococcus granulosus twitchin 0.0665 0.0887 0.1305
Echinococcus multilocularis tyrosine protein kinase Blk 0.0556 0.0693 0.0693
Brugia malayi protein unc-22 0.0264 0.0172 0.0236
Echinococcus multilocularis 0.0655 0.087 0.087
Echinococcus multilocularis cyclin dependent kinase 0.0367 0.0355 0.0355
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0214 0.0083 0.0234
Echinococcus granulosus protein kinase C gamma type 0.0446 0.0497 0.0731
Loa Loa (eye worm) AGC/NDR protein kinase 0.0407 0.0426 0.0586
Schistosoma mansoni vav2 0.0284 0.0207 0.0583
Echinococcus granulosus tyrosine protein kinase Lyn 0.0772 0.1079 0.1586
Brugia malayi Protein kinase domain containing protein 0.0662 0.0882 0.1211
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0275 0.0192 0.0263
Plasmodium falciparum serine/threonine protein kinase KIN 0.0279 0.0199 0.1576
Entamoeba histolytica hypothetical protein 0.0368 0.0357 0.2953
Brugia malayi Sex muscle abnormal protein 5 0.0242 0.0132 0.0182
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0524 0.0635 0.0872
Onchocerca volvulus 0.0296 0.0228 0.0313
Echinococcus granulosus serine:threonine protein kinase 0.0233 0.0116 0.017
Schistosoma mansoni ste20-related kinase 0.0279 0.0199 0.056
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0365 0.0352 0.0517
Brugia malayi Protein kinase domain containing protein 0.0296 0.0228 0.0313
Echinococcus granulosus tyrosine protein kinase Blk 0.0556 0.0693 0.1018
Echinococcus multilocularis activin receptor type 0.2813 0.4723 0.4723
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0395 0.0405 0.0596
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0367 0.0355 0.0707
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0214 0.0083 0.0083
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0791 0.1113 0.1529
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0365 0.0352 0.2903
Echinococcus granulosus lachesin 0.0191 0.0041 0.006
Trichomonas vaginalis CMGC family protein kinase 0.0768 0.1071 0.9152
Schistosoma mansoni serine/threonine protein kinase 0.0758 0.1054 0.2964
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0336 0.03 0.0592
Plasmodium falciparum calcium-dependent protein kinase 4 0.0365 0.0352 0.2903
Trichomonas vaginalis STE family protein kinase 0.0258 0.016 0.1239
Echinococcus multilocularis cyclin dependent kinase 7 0.0344 0.0314 0.0314
Echinococcus multilocularis dual specificity testis specific protein kinase 0.027 0.0182 0.0182
Brugia malayi Immunoglobulin I-set domain containing protein 0.0448 0.0501 0.0688
Brugia malayi cyclin-dependent kinase 7 homolog 0.0367 0.0356 0.0489
Brugia malayi probable protein kinase 0.1129 0.1716 0.2356
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0507 0.0606 0.1233
Loa Loa (eye worm) hypothetical protein 0.0191 0.0041 0.0056
Brugia malayi Immunoglobulin I-set domain containing protein 0.0264 0.0172 0.0236
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0446 0.0496 0.0496
Brugia malayi casein kinase 1, delta 0.0449 0.0501 0.0688
Echinococcus multilocularis PAK box P21 Rho binding 0.0237 0.0123 0.0123
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0446 0.0496 0.0729
Trichomonas vaginalis CK1 family protein kinase 0.0449 0.0501 0.4202
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.056 0.0699 0.0699
Brugia malayi p70 ribosomal S6 kinase beta 0.0526 0.064 0.0879
Echinococcus multilocularis cyclin dependent kinase 1 0.0367 0.0355 0.0355
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0507 0.0606 0.1233
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0365 0.0352 0.2903
Brugia malayi Protein kinase domain containing protein 0.0556 0.0694 0.0952
Echinococcus multilocularis serine threonine protein kinase 0.0446 0.0497 0.0497
Entamoeba histolytica protein kinase domain containing protein 0.0446 0.0496 0.4157
Schistosoma mansoni protein kinase 0.0237 0.0123 0.0345
Brugia malayi Protein kinase domain containing protein 0.0287 0.0213 0.0293
Trypanosoma cruzi Protein kinase B 0.0262 0.0169 0.0316
Onchocerca volvulus 0.0546 0.0675 0.0926
Echinococcus multilocularis cyclin dependent kinase 1 0.0367 0.0355 0.0355
Echinococcus granulosus tyrosine protein kinase Src64B 0.0659 0.0878 0.129
Trichomonas vaginalis CMGC family protein kinase 0.0367 0.0355 0.2932
Echinococcus granulosus protein kinase c epsilon type 0.0524 0.0635 0.0934
Schistosoma mansoni tyrosine kinase 0.06 0.0772 0.2169
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0213 0.008 0.0626
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0367 0.0355 0.0488
Schistosoma mansoni rap gtpase-activating protein 0.0483 0.0563 0.1582
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0279 0.0199 0.038
Plasmodium falciparum serine/threonine protein kinase, putative 0.0446 0.0496 0.4157
Echinococcus granulosus serine:threonine protein kinase mig 15 0.1016 0.1515 0.2227
Loa Loa (eye worm) TK/FER protein kinase 0.0296 0.0228 0.0313
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0589 0.0753 0.0753
Echinococcus multilocularis casein kinase I alpha 0.0449 0.0501 0.0501
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0221 0.0095 0.0095
Schistosoma mansoni tyrosine kinase 0.0443 0.0491 0.138
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0365 0.0352 0.0483
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Plasmodium falciparum calcium-dependent protein kinase 1 0.0365 0.0352 0.2903
Brugia malayi Immunoglobulin I-set domain containing protein 0.0191 0.0041 0.0056
Brugia malayi Protein kinase domain containing protein 0.0515 0.062 0.0852
Schistosoma mansoni protein kinase 0.027 0.0182 0.0513
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0778 0.1089 0.2244
Loa Loa (eye worm) hypothetical protein 0.0615 0.0799 0.1097
Echinococcus multilocularis transfer RNA-Thr 0.1146 0.1746 0.1746
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0556 0.0693 0.0693
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0407 0.0426 0.0586
Loa Loa (eye worm) AUR protein kinase 0.0446 0.0496 0.0681
Loa Loa (eye worm) hypothetical protein 0.0427 0.0462 0.0635
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1689 0.2716 0.3994
Echinococcus granulosus titin 0.0264 0.0172 0.0252
Plasmodium vivax serine/threonine kinase-1, putative 0.0768 0.1071 0.916
Entamoeba histolytica protein kinase, putative 0.0446 0.0496 0.4157
Echinococcus granulosus titin 0.0264 0.0172 0.0252
Echinococcus multilocularis protein kinase shaggy 0.0822 0.1168 0.1168
Echinococcus multilocularis serine:threonine protein kinase N2 0.0893 0.1295 0.1295
Brugia malayi SH2 domain containing protein 0.0296 0.0228 0.0313
Entamoeba histolytica protein kinase, putative 0.0251 0.0148 0.1137
Echinococcus granulosus casein kinase I alpha 0.0449 0.0501 0.0737
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0251 0.0148 0.0203
Onchocerca volvulus 0.4247 0.7281 1
Trypanosoma cruzi casein kinase, putative 0.0449 0.0501 0.1013
Loa Loa (eye worm) hypothetical protein 0.0279 0.0199 0.0273
Brugia malayi cyclin-dependent kinase 9 0.0246 0.014 0.0193
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0254 0.0154 0.0433
Schistosoma mansoni titin 0.0264 0.0172 0.0482
Schistosoma mansoni serine/threonine protein kinase 0.113 0.1717 0.4828
Onchocerca volvulus Slit protein homolog 0.0188 0.0036 0.0049
Schistosoma mansoni protein kinase 0.1689 0.2716 0.7637
Schistosoma mansoni tyrosine kinase 0.216 0.3557 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0367 0.0355 0.2932
Onchocerca volvulus 0.0563 0.0705 0.0969
Echinococcus multilocularis tyrosine protein kinase shark 0.0502 0.0597 0.0597
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1028 0.1536 0.2109
Brugia malayi Immunoglobulin I-set domain containing protein 0.0191 0.0041 0.0056
Echinococcus multilocularis hemicentin 1 0.0191 0.0041 0.0041
Giardia lamblia Kinase, CAMK CAMKL 0.0303 0.0241 0.194
Schistosoma mansoni growth factor receptor-bound protein 0.0253 0.0153 0.0429
Echinococcus multilocularis N chimaerin 0.0254 0.0154 0.0154
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0254 0.0154 0.0154
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0232 0.0115 0.0849
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0347 0.032 0.032
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0449 0.0501 0.0688
Echinococcus multilocularis protein kinase c epsilon type 0.0524 0.0635 0.0635
Brugia malayi EGF-like domain containing protein 0.0188 0.0036 0.0049
Onchocerca volvulus 0.0264 0.0172 0.0236
Brugia malayi Protein kinase domain containing protein 0.0296 0.0228 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.0362 0.0347 0.0976
Onchocerca volvulus 0.0679 0.0912 0.1253
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0768 0.1071 0.1471
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0822 0.1168 0.1718
Echinococcus granulosus protein kinase c iota type 0.0603 0.0776 0.1141
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0362 0.0347 0.0511
Echinococcus multilocularis c src tyrosine kinase 0.0399 0.0413 0.0413
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0507 0.0606 0.0606
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0822 0.1168 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0507 0.0606 0.0891
Trichomonas vaginalis AGC family protein kinase 0.0407 0.0426 0.3552
Schistosoma mansoni serine/threonine protein kinase 0.0463 0.0526 0.1479
Loa Loa (eye worm) hypothetical protein 0.0214 0.0083 0.0114
Loa Loa (eye worm) hypothetical protein 0.0381 0.038 0.0522
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0507 0.0606 0.1233
Echinococcus multilocularis cyclin dependent kinase 5 0.0367 0.0355 0.0355
Echinococcus multilocularis 0.0174 0.0011 0.0011
Leishmania major protein kinase A catalytic subunit isoform 2 0.0507 0.0606 0.1233
Loa Loa (eye worm) hypothetical protein 0.0538 0.0661 0.0907
Echinococcus granulosus NCK adaptor protein 0.0242 0.0132 0.0195
Trypanosoma brucei polo-like protein kinase 0.0251 0.0148 0.0273
Onchocerca volvulus 0.0296 0.0228 0.0313
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0367 0.0355 0.0522
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.14 0.2199 0.3021
Trichomonas vaginalis CK1 family protein kinase 0.0449 0.0501 0.4202
Giardia lamblia Kinase, CMGC DYRK 0.0215 0.0085 0.0584
Echinococcus granulosus mitogen activated protein kinase 11 0.2852 0.4791 0.7044
Brugia malayi Protein kinase domain containing protein 0.1146 0.1746 0.2398
Echinococcus granulosus tyrosine protein kinase Fyn 0.0659 0.0878 0.129
Loa Loa (eye worm) hypothetical protein 0.0616 0.0799 0.1098
Loa Loa (eye worm) TK/INSR protein kinase 0.0889 0.1287 0.1767
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.1794 0.2903 0.2903
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0362 0.0347 0.0347
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0277 0.0195 0.0268
Brugia malayi Variant SH3 domain containing protein 0.0242 0.0132 0.0182
Trichomonas vaginalis CMGC family protein kinase 0.0367 0.0355 0.2932
Schistosoma mansoni serine/threonine protein kinase 0.0989 0.1466 0.4122
Toxoplasma gondii AGC kinase 0.0526 0.064 0.541
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0258 0.016 0.0236
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0214 0.0083 0.0083
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0251 0.0148 0.0273
Loa Loa (eye worm) hypothetical protein 0.2339 0.3875 0.5322
Trichomonas vaginalis AGC family protein kinase 0.0556 0.0694 0.5873
Echinococcus multilocularis dual specificity 0.0728 0.1001 0.1001
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Brugia malayi Fibronectin type III domain containing protein 0.0448 0.0501 0.0688
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0148 0.1134
Entamoeba histolytica protein kinase, putative 0.0556 0.0694 0.5873
Brugia malayi serine/threonine kinase 12 0.0446 0.0496 0.0681
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0277 0.0195 0.0268
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0822 0.1168 0.2411
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.0199 0.0559
Loa Loa (eye worm) hypothetical protein 0.0679 0.0912 0.1253
Schistosoma mansoni serine/threonine protein kinase 0.0851 0.1219 0.3427
Loa Loa (eye worm) hypothetical protein 0.0448 0.0501 0.0688
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0778 0.1089 0.1495
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0822 0.1168 0.1605
Trichomonas vaginalis AGC family protein kinase 0.0556 0.0694 0.5873
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0778 0.1089 0.2244
Loa Loa (eye worm) hypothetical protein 0.0242 0.0132 0.0182
Brugia malayi Immunoglobulin I-set domain containing protein 0.0191 0.0041 0.0056
Echinococcus multilocularis serine:threonine protein kinase N2 0.0407 0.0426 0.0426
Trichomonas vaginalis AGC family protein kinase 0.0446 0.0496 0.4157
Echinococcus multilocularis raf serine:threonine protein kinase 0.0273 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0483 0.0563 0.0773
Schistosoma mansoni serine/threonine protein kinase 0.0507 0.0606 0.1704
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0407 0.0426 0.0627
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0233 0.0116 0.0159
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0768 0.1071 0.2207
Trichomonas vaginalis STE family protein kinase 0.0213 0.008 0.0541
Plasmodium vivax casein kinase 1, putative 0.0449 0.0501 0.4254
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0758 0.1054 0.155
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0646 0.0854 0.1172
Echinococcus multilocularis tyrosine kinase 0.0296 0.0228 0.0228
Echinococcus granulosus hypothetical protein 0.0655 0.087 0.1279
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.027 0.0182 0.0345
Echinococcus multilocularis 0.0646 0.0854 0.0854
Brugia malayi protein-tyrosine kinase 0.0556 0.0693 0.0951
Onchocerca volvulus 0.0483 0.0563 0.0773
Loa Loa (eye worm) TK/EGFR protein kinase 0.0734 0.1012 0.1389
Entamoeba histolytica PH domain containing protein kinase, putative 0.0262 0.0169 0.1312
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Loa Loa (eye worm) TK/FER protein kinase 0.0296 0.0228 0.0313
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0659 0.0878 0.0878
Onchocerca volvulus 0.0449 0.0501 0.0688
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0507 0.0606 0.1233
Brugia malayi Peroxidasin 0.0193 0.0044 0.0061
Loa Loa (eye worm) hypothetical protein 0.0168 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.1016 0.1515 0.208
Plasmodium falciparum cGMP-dependent protein kinase 0.0211 0.0077 0.0518
Brugia malayi Protein kinase domain containing protein 0.024 0.0128 0.0176
Loa Loa (eye worm) CAMK/PHK protein kinase 0.024 0.0128 0.0176
Brugia malayi STE20-like kinase MST 0.033 0.0289 0.0396
Echinococcus multilocularis serine:threonine protein kinase 0.0233 0.0116 0.0116
Loa Loa (eye worm) AGC/PKG protein kinase 0.0211 0.0077 0.0106
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0279 0.0199 0.038
Trypanosoma cruzi cdc2-related kinase 1 0.0367 0.0355 0.0707
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0258 0.016 0.0236
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Giardia lamblia Kinase, STE STE20 0.0258 0.016 0.1239
Schistosoma mansoni cell adhesion molecule 0.0214 0.0083 0.0234
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0659 0.0878 0.0878
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0315 0.0264 0.0362
Echinococcus granulosus TGF-beta receptor type-1 0.0611 0.0791 0.1162
Echinococcus granulosus slit 2 protein 0.0188 0.0036 0.0053
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0264 0.0172 0.0236
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.1689 0.2716 0.3731
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0589 0.0753 0.1107
Schistosoma mansoni septate junction protein 0.0191 0.0041 0.0115
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0483 0.0563 0.1582
Echinococcus granulosus aurora kinase A 0.0446 0.0496 0.0729
Trichomonas vaginalis AGC family protein kinase 0.0407 0.0426 0.3552
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0215 0.0085 0.0141
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0365 0.0352 0.0517
Trypanosoma cruzi casein kinase, putative 0.0449 0.0501 0.1013
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0526 0.064 0.0879
Brugia malayi casein kinase I 0.0449 0.0501 0.0688
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0227 0.0105 0.0145
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0258 0.016 0.016
Echinococcus granulosus cyclin dependent kinase 7 0.0344 0.0314 0.0462
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0822 0.1168 0.1168
Loa Loa (eye worm) hypothetical protein 0.0546 0.0675 0.0926
Entamoeba histolytica PH domain containing protein kinase, putative 0.0537 0.0659 0.5577
Echinococcus granulosus serine:threonine protein kinase 0.0233 0.0116 0.017
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0367 0.0355 0.2932
Loa Loa (eye worm) hypothetical protein 0.0425 0.0459 0.063
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0425 0.0459 0.1289
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0365 0.0352 0.2903
Schistosoma mansoni serine/threonine protein kinase 0.0362 0.0347 0.0976
Entamoeba histolytica casein kinase, putative 0.0449 0.0501 0.4202
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1941 0.3166 0.3166
Brugia malayi Protein kinase domain 0.0258 0.016 0.022
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0178 0.0018 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.0199 0.0559
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0199 0.1576
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0215 0.0085 0.0117

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 40 uM Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid scintillation counting ChEMBL. 19574055
Ki (binding) > 40 uM Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs by scintillation counting ChEMBL. 19574055

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.