Detailed information for compound 1052771

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 427.3 | Formula: C19H11F6N3O2
  • H donors: 2 H acceptors: 2 LogP: 4.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C(/c1cccnc1Oc1c(F)c(F)cc(c1F)F)\NCc1cc(F)ccc1F
  • InChi: 1S/C19H11F6N3O2/c20-10-3-4-12(21)9(6-10)8-27-18(28-29)11-2-1-5-26-19(11)30-17-15(24)13(22)7-14(23)16(17)25/h1-7,29H,8H2,(H,27,28)
  • InChiKey: DWNDNBOIYSAOBF-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0325 0.0115 0.0201
Onchocerca volvulus 0.0755 0.0633 0.086
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.1288 0.1276 0.1735
Trypanosoma cruzi cdc2-related kinase 1 0.0418 0.0226 0.0396
Loa Loa (eye worm) TK/FER protein kinase 0.0437 0.0249 0.0339
Trypanosoma brucei protein kinase, putative 0.1088 0.1034 0.1809
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.2119 0.2277 0.2277
Schistosoma mansoni tyrosine kinase 0.0655 0.0512 0.126
Schistosoma mansoni serine/threonine protein kinase 0.0327 0.0117 0.0287
Schistosoma mansoni protein kinase 0.1143 0.1101 0.271
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.4972 0.5719 1
Echinococcus granulosus epidermal growth factor receptor 0.0955 0.0874 0.1528
Entamoeba histolytica protein kinase, putative 0.0517 0.0346 0.3341
Trichomonas vaginalis STE family protein kinase 0.0351 0.0146 0.1326
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0293 0.0076 0.0076
Onchocerca volvulus 0.0362 0.0159 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.0484 0.0306 0.0752
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0687 0.0551 0.5323
Echinococcus granulosus protein kinase c iota type 0.0739 0.0614 0.1073
Schistosoma mansoni serine/threonine protein kinase 0.0286 0.0067 0.0166
Loa Loa (eye worm) TK/FER protein kinase 0.0437 0.0249 0.0339
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0687 0.0551 0.0963
Echinococcus granulosus serine:threonine protein kinase N2 0.1067 0.1009 0.1764
Echinococcus granulosus tyrosine protein kinase Fyn 0.1021 0.0953 0.1667
Brugia malayi Tyrosine-protein kinase abl-1 0.1055 0.0994 0.1352
Echinococcus granulosus NCK adaptor protein 0.0371 0.0169 0.0296
Loa Loa (eye worm) hypothetical protein 0.0858 0.0757 0.1029
Trichomonas vaginalis AGC family protein kinase 0.0679 0.0541 0.4909
Schistosoma mansoni serine/threonine protein kinase 0.0925 0.0838 0.2063
Echinococcus multilocularis dual specificity 0.0261 0.0036 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0437 0.0249 0.0339
Echinococcus granulosus cGMP dependent protein kinase 0.0256 0.0031 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Onchocerca volvulus 0.09 0.0808 0.1098
Schistosoma mansoni growth factor receptor-bound protein 0.0371 0.0169 0.0417
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0633 0.0486 0.085
Echinococcus granulosus protein kinase c epsilon type 0.0656 0.0513 0.0897
Echinococcus granulosus casein kinase i 0.0581 0.0423 0.0739
Schistosoma mansoni protein kinase 0.2157 0.2324 0.572
Trypanosoma cruzi polo-like protein kinase, putative 0.0298 0.0081 0.0142
Brugia malayi Immunoglobulin I-set domain containing protein 0.0261 0.0037 0.005
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0383 0.0184 0.1778
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0358 0.0154 0.1396
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1088 0.1034 0.2546
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0691 0.0556 0.0756
Echinococcus granulosus tyrosine protein kinase Src42A 0.0642 0.0496 0.0868
Loa Loa (eye worm) TK/FER protein kinase 0.0437 0.0249 0.0339
Loa Loa (eye worm) hypothetical protein 0.0712 0.0581 0.079
Brugia malayi Protein kinase domain containing protein 0.0418 0.0226 0.0308
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.4972 0.5719 1
Echinococcus multilocularis dual specificity 0.1067 0.1009 0.1009
Trichomonas vaginalis STE family protein kinase 0.0351 0.0146 0.1326
Echinococcus multilocularis rac serine:threonine kinase 0.0321 0.0109 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.0066 0.0163
Schistosoma mansoni nephrin 0.0779 0.0662 0.1629
Echinococcus multilocularis activin receptor type 0.3784 0.4286 0.4286
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1346 0.1345 0.2352
Loa Loa (eye worm) hypothetical protein 0.0266 0.0043 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.0318 0.0106 0.0262
Echinococcus multilocularis epidermal growth factor receptor 0.0814 0.0703 0.0703
Echinococcus granulosus lachesin 0.0261 0.0037 0.0064
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1346 0.1345 0.1829
Leishmania major protein kinase, putative 0.0959 0.0879 0.1538
Schistosoma mansoni tyrosine kinase 0.0583 0.0426 0.1048
Schistosoma mansoni serine/threonine protein kinase 0.0375 0.0174 0.0428
Echinococcus granulosus growth factor receptor bound protein 2 0.0386 0.0188 0.0328
Loa Loa (eye worm) hypothetical protein 0.0883 0.0787 0.107
Loa Loa (eye worm) hypothetical protein 0.0568 0.0407 0.0554
Echinococcus granulosus TGF beta receptor type 1 0.0818 0.0709 0.124
Toxoplasma gondii AGC kinase 0.0687 0.0551 0.5323
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0266 0.0044 0.0076
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0516 0.0344 0.0344
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0351 0.0146 0.0146
Trichomonas vaginalis TKL family protein kinase 0.0232 0.0002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0915 0.0825 0.1122
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0516 0.0344 0.0602
Entamoeba histolytica protein kinase domain containing protein 0.1067 0.1009 0.9757
Brugia malayi Protein kinase domain containing protein 0.0402 0.0207 0.0282
Loa Loa (eye worm) hypothetical protein 0.0602 0.0449 0.061
Echinococcus multilocularis slit 2 protein 0.0254 0.0029 0.0029
Brugia malayi SH2 domain containing protein 0.0437 0.0249 0.0339
Loa Loa (eye worm) IKK protein kinase 0.6329 0.7355 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0756 0.0635 0.0635
Entamoeba histolytica protein kinase, putative 0.0557 0.0394 0.3813
Echinococcus multilocularis calcium activated potassium channel 0.0318 0.0106 0.0106
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0687 0.0551 0.0963
Echinococcus multilocularis Immunoglobulin 0.057 0.041 0.041
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0418 0.0226 0.0308
Plasmodium vivax glycogen synthase kinase 3, putative 0.1088 0.1034 1
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0081 0.074
Loa Loa (eye worm) hypothetical protein 0.0327 0.0117 0.0159
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0261 0.0037 0.005
Loa Loa (eye worm) hypothetical protein 0.1222 0.1196 0.1627
Echinococcus multilocularis cyclin dependent kinase 1 0.0418 0.0226 0.0226
Trichomonas vaginalis AGC family protein kinase 0.051 0.0338 0.3065
Schistosoma mansoni growth factor receptor-bound protein 0.0386 0.0188 0.0462
Loa Loa (eye worm) hypothetical protein 0.4048 0.4605 0.626
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Giardia lamblia Kinase, AGC PKA 0.0278 0.0058 0.0528
Schistosoma mansoni serine/threonine-protein kinase 0.0321 0.0109 0.0269
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0687 0.0551 0.0963
Echinococcus multilocularis Immunoglobulin 0.057 0.041 0.041
Entamoeba histolytica protein kinase domain containing protein 0.0261 0.0036 0.0353
Schistosoma mansoni serine/threonine protein kinase 0.0516 0.0344 0.0847
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0959 0.0879 0.1538
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0557 0.0394 0.3813
Echinococcus multilocularis casein kinase i 0.0581 0.0423 0.0423
Loa Loa (eye worm) TK/INSR protein kinase 0.126 0.1242 0.1689
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Loa Loa (eye worm) hypothetical protein 0.1367 0.1371 0.1864
Onchocerca volvulus 0.0437 0.0249 0.0339
Schistosoma mansoni serine/threonine protein kinase 0.0362 0.0159 0.039
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.2674 0.2947 0.4007
Loa Loa (eye worm) SRC-1 0.1021 0.0953 0.1296
Echinococcus granulosus serine:threonine kinase SAD 1 0.0327 0.0117 0.0204
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0407 0.0214 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.0959 0.0879 0.2164
Loa Loa (eye worm) hypothetical protein 0.0831 0.0724 0.0985
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.051 0.0338 0.059
Echinococcus granulosus neuroglian 0.0293 0.0076 0.0132
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0293 0.0076 0.0076
Brugia malayi Protein kinase domain containing protein 0.0437 0.0249 0.0339
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0581 0.0423 0.0739
Plasmodium falciparum serine/threonine protein kinase, putative 0.0557 0.0394 0.3813
Trichomonas vaginalis AGC family protein kinase 0.0679 0.0541 0.4909
Loa Loa (eye worm) hypothetical protein 0.0261 0.0037 0.005
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0258 0.0033 0.0319
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0402 0.0207 0.0282
Schistosoma mansoni tyrosine kinase 0.0448 0.0262 0.0646
Onchocerca volvulus Tyrosine kinase homolog 0.2724 0.3008 0.409
Echinococcus multilocularis PAK box P21 Rho binding 0.0329 0.0119 0.0119
Echinococcus multilocularis tyrosine kinase 0.0437 0.0249 0.0249
Echinococcus granulosus titin 0.0362 0.0159 0.0277
Echinococcus granulosus roundabout 2 0.0293 0.0076 0.0132
Schistosoma mansoni serine/threonine protein kinase 0.0687 0.0551 0.1355
Schistosoma mansoni serine/threonine protein kinase 0.0605 0.0452 0.1112
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0687 0.0551 0.0963
Onchocerca volvulus 0.0602 0.0449 0.061
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0418 0.0226 0.0396
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0516 0.0344 0.0344
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0687 0.0551 0.0749
Brugia malayi cell division control protein 2 homolog 0.0418 0.0226 0.0308
Schistosoma mansoni protein kinase 0.0315 0.0103 0.0253
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0381 0.0181 0.0247
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1346 0.1345 0.1829
Schistosoma mansoni cell adhesion molecule 0.0261 0.0037 0.0091
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0327 0.0117 0.0204
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0516 0.0344 0.0468
Echinococcus granulosus cGMP dependent protein kinase 1 0.0256 0.0031 0.0054
Schistosoma mansoni tyrosine kinase 0.0814 0.0703 0.1731
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2238 0.2422 0.4234
Echinococcus multilocularis cyclin dependent kinase 9 0.0338 0.013 0.013
Schistosoma mansoni vam6/vps39 related 0.0633 0.0486 0.1196
Echinococcus multilocularis dual specificity 0.0261 0.0036 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0755 0.0633 0.1557
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0866 0.0767 0.1042
Onchocerca volvulus 0.0581 0.0423 0.0575
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0351 0.0146 0.0359
Schistosoma mansoni vav2 0.0394 0.0197 0.0485
Schistosoma mansoni protein kinase 0.0329 0.0119 0.0294
Schistosoma mansoni protein kinase C mu 0.101 0.0941 0.2315
Echinococcus granulosus calcium dependent protein kinase 0.0363 0.016 0.028
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0633 0.0486 0.0486
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0892 0.0798 0.1085
Loa Loa (eye worm) hypothetical protein 0.0712 0.0581 0.079
Entamoeba histolytica protein kinase, putative 0.1067 0.1009 0.9757
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0081 0.074
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0534 0.0367 0.0367
Echinococcus granulosus tyrosine protein kinase Fyn 0.1021 0.0953 0.1667
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0351 0.0146 0.0359
Entamoeba histolytica casein kinase 1, putative 0.0581 0.0423 0.4087
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.072 0.0591 0.0804
Brugia malayi Sex muscle abnormal protein 5 0.0371 0.0169 0.023
Echinococcus multilocularis dual specificity protein kinase clk2 0.0959 0.0879 0.0879
Schistosoma mansoni protein kinase 0.0818 0.0709 0.1746
Echinococcus multilocularis roundabout 2 0.0293 0.0076 0.0076
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.4972 0.5719 0.7776
Onchocerca volvulus 0.0437 0.0249 0.0339
Echinococcus multilocularis titin 0.0362 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0318 0.0106 0.0261
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0261 0.0036 0.0064
Loa Loa (eye worm) TK/FAK protein kinase 0.364 0.4112 0.559
Loa Loa (eye worm) hypothetical protein 0.0712 0.0581 0.079
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0959 0.0879 0.1538
Entamoeba histolytica protein kinase, putative 0.065 0.0506 0.4893
Echinococcus multilocularis growth factor receptor bound protein 2 0.0371 0.0169 0.0169
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0521 0.035 0.0612
Echinococcus multilocularis protein kinase c epsilon type 0.0656 0.0513 0.0513
Echinococcus multilocularis dual specificity mitogen activated protein 0.1143 0.1101 0.1101
Trypanosoma brucei protein kinase, putative 0.0237 0.0008 0.0014
Echinococcus multilocularis serine:threonine protein kinase N2 0.051 0.0338 0.0338
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0687 0.0551 0.0551
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0516 0.0344 0.3326
Brugia malayi serine/threonine-protein kinase PAK 7 0.2049 0.2193 0.2982
Echinococcus multilocularis NCK adaptor protein 0.0386 0.0188 0.0188
Schistosoma mansoni serine/threonine kinase 0.051 0.0338 0.0831
Trichomonas vaginalis AGC family protein kinase 0.0687 0.0551 0.5
Echinococcus granulosus casein kinase I gamma 0.0336 0.0128 0.0223
Echinococcus granulosus hypothetical protein 0.0807 0.0696 0.1216
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0516 0.0344 0.0468
Onchocerca volvulus 0.0437 0.0249 0.0339
Leishmania major casein kinase, putative 0.0581 0.0423 0.0739
Schistosoma mansoni serine/threonine protein kinase 0.051 0.0338 0.0831
Echinococcus multilocularis protein tyrosine kinase 0.36 0.4063 0.4063
Schistosoma mansoni serine/threonine protein kinase 0.1524 0.156 0.384
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.2333 0.2536 0.2536
Loa Loa (eye worm) hypothetical protein 0.0261 0.0037 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Trichomonas vaginalis CMGC family protein kinase 0.0418 0.0226 0.2056
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0557 0.0394 0.069
Echinococcus granulosus TGF-beta receptor type-1 0.0818 0.0709 0.124
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1346 0.1345 0.1829
Echinococcus granulosus serine:threonine protein kinase 3 0.0381 0.0181 0.0317
Schistosoma mansoni serine/threonine protein kinase 0.0581 0.0423 0.104
Schistosoma mansoni cell adhesion molecule 0.0293 0.0076 0.0186
Echinococcus multilocularis rho associated protein kinase 0.0755 0.0633 0.0633
Loa Loa (eye worm) AGC/PKA protein kinase 0.0687 0.0551 0.0749
Trichomonas vaginalis STE family protein kinase 0.0351 0.0146 0.1326
Entamoeba histolytica protein kinase, putative 0.0679 0.0541 0.5227
Echinococcus multilocularis serine:threonine protein kinase 38 0.051 0.0338 0.0338
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0445 0.026 0.0353
Loa Loa (eye worm) hypothetical protein 0.09 0.0808 0.1098
Loa Loa (eye worm) protein kinase domain-containing protein 0.0336 0.0128 0.0174
Brugia malayi Prion-like- 0.0261 0.0037 0.005
Brugia malayi hypothetical protein 0.0633 0.0486 0.0661
Loa Loa (eye worm) AGC/NDR protein kinase 0.051 0.0338 0.0459
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0687 0.0551 0.0963
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0786 0.067 0.067
Echinococcus granulosus casein kinase I alpha 0.0581 0.0423 0.0739
Trypanosoma cruzi cdc2-related kinase 3 0.0418 0.0226 0.0396
Giardia lamblia Kinase, NEK 0.0258 0.0033 0.03
Brugia malayi Protein kinase domain containing protein 0.073 0.0603 0.082
Trypanosoma cruzi aurora B kinase, putative 0.0557 0.0394 0.069
Brugia malayi Protein kinase domain containing protein 0.0437 0.0249 0.0339
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0418 0.0226 0.0308
Entamoeba histolytica PH domain containing protein kinase, putative 0.0729 0.0602 0.5817
Brugia malayi Immunoglobulin I-set domain containing protein 0.0261 0.0037 0.005
Echinococcus multilocularis protein kinase shaggy 0.1088 0.1034 0.1034
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1021 0.0953 0.0953
Toxoplasma gondii histone kinase SNF1, putative 0.0327 0.0117 0.1129
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.051 0.0338 0.0338
Loa Loa (eye worm) TK protein kinase 0.0857 0.0756 0.1027
Echinococcus granulosus Protein kinase C brain isozyme 0.0696 0.0562 0.0983
Entamoeba histolytica hypothetical protein 0.0233 0.0003 0.0032
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0383 0.0184 0.0184
Brugia malayi RhoGAP domain containing protein 0.0351 0.0146 0.0198
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0383 0.0184 0.0321
Brugia malayi Variant SH3 domain containing protein 0.0371 0.0169 0.023
Entamoeba histolytica hypothetical protein 0.0233 0.0003 0.0032
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0516 0.0344 0.3326
Entamoeba histolytica protein kinase, putative 0.0359 0.0156 0.1505
Loa Loa (eye worm) TK/FER protein kinase 0.0437 0.0249 0.0339
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1088 0.1034 0.1809
Schistosoma mansoni serine/threonine protein kinase 0.2119 0.2277 0.5604
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.036 0.0156 0.1509
Trichomonas vaginalis AGC family protein kinase 0.0543 0.0377 0.3422
Loa Loa (eye worm) AUR protein kinase 0.0557 0.0394 0.0536
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1478 0.1505 0.2046
Brugia malayi Protein kinase domain containing protein 0.073 0.0603 0.082
Onchocerca volvulus 0.0318 0.0106 0.0144
Loa Loa (eye worm) hypothetical protein 0.0318 0.0105 0.0143
Echinococcus granulosus MAM 0.0318 0.0106 0.0186
Brugia malayi map kinase activated protein kinase protein 2 0.0521 0.035 0.0476
Loa Loa (eye worm) AGC/AKT protein kinase 0.0679 0.0541 0.0735
Echinococcus granulosus twitchin 0.09 0.0807 0.1411
Echinococcus granulosus mitogen activated protein kinase 11 0.4972 0.5719 1
Toxoplasma gondii aurora kinase 0.0557 0.0394 0.3813
Loa Loa (eye worm) CAMK protein kinase 0.0362 0.0159 0.0216
Plasmodium falciparum glycogen synthase kinase 3 0.1088 0.1034 1
Schistosoma mansoni tyrosine kinase 0.0955 0.0874 0.2151
Schistosoma mansoni serine/threonine protein kinase 0.0338 0.013 0.032
Brugia malayi Protein kinase domain containing protein 0.4598 0.5268 0.7162
Entamoeba histolytica protein kinase domain containing protein 0.0271 0.0049 0.0477
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.1818 0.1914 0.2603
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0516 0.0344 0.0602
Brugia malayi protein unc-22 0.0362 0.0159 0.0216
Trichomonas vaginalis CMGC family protein kinase 0.0418 0.0226 0.2056
Loa Loa (eye worm) gastrulation defective protein 1 0.1483 0.1511 0.2054
Brugia malayi Immunoglobulin I-set domain containing protein 0.0261 0.0037 0.005
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0959 0.0879 0.1538
Schistosoma mansoni serine/threonine protein kinase 0.0696 0.0562 0.1383
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.051 0.0338 0.059
Loa Loa (eye worm) TK/ABL protein kinase 0.2145 0.2309 0.3139
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0293 0.0076 0.0076
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0581 0.0423 0.0575
Brugia malayi Protein kinase domain containing protein 0.2157 0.2324 0.316
Schistosoma mansoni serine/threonine protein kinase 0.0327 0.0117 0.0287
Echinococcus multilocularis mitogen activated protein kinase 14 0.4972 0.5719 0.5719
Echinococcus multilocularis serine:threonine protein kinase N2 0.1577 0.1624 0.1624
Leishmania major protein kinase, putative 0.0959 0.0879 0.1538
Loa Loa (eye worm) hypothetical protein 0.0249 0.0023 0.0031
Trichomonas vaginalis CMGC family protein kinase 0.0959 0.0879 0.7986
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0397 0.0201 0.0201
Onchocerca volvulus 0.035 0.0145 0.0197
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0371 0.0169 0.023
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0318 0.0105 0.0143
Echinococcus granulosus raf serine:threonine protein kinase 0.0375 0.0174 0.0304
Echinococcus granulosus casein kinase I alpha 0.0581 0.0423 0.0739
Toxoplasma gondii AGC kinase 0.0636 0.049 0.4733
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.1818 0.1914 0.2603
Trypanosoma cruzi Protein kinase B 0.0321 0.0109 0.0191
Schistosoma mansoni hypothetical protein 0.0318 0.0106 0.0261
Trichomonas vaginalis AGC family protein kinase 0.0557 0.0394 0.3581
Trichomonas vaginalis CAMK family protein kinase 0.033 0.0121 0.1096
Brugia malayi cyclin-dependent kinase 7 homolog 0.0655 0.0512 0.0697
Echinococcus granulosus tyrosine protein kinase Lyn 0.1173 0.1137 0.1988
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.4675 0.536 0.9372
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0351 0.0146 0.0146
Echinococcus multilocularis tyrosine protein kinase Srms 0.0857 0.0756 0.0756
Schistosoma mansoni tyrosine kinase 0.0583 0.0426 0.1048
Schistosoma mansoni tyrosine kinase 0.1352 0.1353 0.3329
Brugia malayi serine/threonine protein kinase 6 0.0557 0.0394 0.0536
Echinococcus multilocularis casein kinase I delta 0.0581 0.0423 0.0423
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0484 0.0306 0.0306
Loa Loa (eye worm) TK/FER protein kinase 0.0437 0.0249 0.0339
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0431 0.0243 0.033
Schistosoma mansoni serine/threonine protein kinase 0.0327 0.0117 0.0287
Echinococcus multilocularis roundabout 2 0.0293 0.0076 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Schistosoma mansoni protein kinase 0.0581 0.0423 0.104
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0256 0.0031 0.0031
Echinococcus multilocularis 0.0807 0.0696 0.0696
Brugia malayi Protein kinase domain containing protein 0.051 0.0338 0.0459
Brugia malayi Protein kinase domain 0.0351 0.0146 0.0198
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.1143 0.1101 0.1925
Brugia malayi Protein kinase domain containing protein 0.0336 0.0128 0.0174
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.1067 0.1009 0.1765
Echinococcus granulosus epidermal growth factor receptor 0.0814 0.0703 0.123
Echinococcus multilocularis casein kinase I alpha 0.0581 0.0423 0.0423
Echinococcus multilocularis tyrosine protein kinase Src64B 0.1021 0.0953 0.0953
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1088 0.1034 1
Schistosoma mansoni tyrosine kinase 0.0601 0.0447 0.11
Plasmodium falciparum calcium-dependent protein kinase 1 0.0516 0.0344 0.3326
Loa Loa (eye worm) hypothetical protein 0.0526 0.0357 0.0485
Schistosoma mansoni cell adhesion molecule 0.0293 0.0076 0.0186
Loa Loa (eye worm) TK protein kinase 0.065 0.0506 0.0688
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0286 0.0067 0.0067
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.1635 0.1695 0.2304
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0687 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0915 0.0825 0.1122
Brugia malayi Immunoglobulin I-set domain containing protein 0.0602 0.0449 0.061
Loa Loa (eye worm) hypothetical protein 0.0756 0.0635 0.0863
Schistosoma mansoni serine/threonine protein kinase 0.051 0.0338 0.0831
Schistosoma mansoni tyrosine kinase 0.126 0.1242 0.3057
Brugia malayi Protein kinase domain containing protein 0.1635 0.1695 0.2304
Loa Loa (eye worm) hypothetical protein 0.0264 0.004 0.0055
Echinococcus multilocularis dual specificity 0.0261 0.0036 0.0036
Trypanosoma brucei protein kinase, putative 0.0383 0.0184 0.0321
Brugia malayi STE20-like kinase MST 0.0381 0.0181 0.0247
Loa Loa (eye worm) hypothetical protein 0.0261 0.0037 0.005
Leishmania major protein kinase, putative 0.0516 0.0344 0.0602
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.2674 0.2947 0.2947
Brugia malayi Variant SH3 domain containing protein 0.0351 0.0146 0.0198
Loa Loa (eye worm) hypothetical protein 0.047 0.0289 0.0394
Trichomonas vaginalis CK1 family protein kinase 0.0581 0.0423 0.3839
Echinococcus multilocularis expressed conserved protein 0.0256 0.0031 0.0031
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0687 0.0551 0.0551
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Echinococcus granulosus dual specificity 0.0261 0.0036 0.0064
Schistosoma mansoni serine/threonine protein kinase 0.1067 0.1009 0.2484
Brugia malayi Variant SH3 domain containing protein 0.0371 0.0169 0.023
Echinococcus multilocularis ephrin type A receptor 4 A 0.0296 0.0079 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0557 0.0394 0.3813
Echinococcus granulosus tyrosine protein kinase ABL1 0.2145 0.2309 0.4037
Leishmania major protein kinase, putative 0.0383 0.0184 0.0321
Trichomonas vaginalis AGC family protein kinase 0.051 0.0338 0.3065
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.2049 0.2193 0.2982
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0581 0.0423 0.0575
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1293 0.1281 0.224
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0234 0.0005 0.0007
Schistosoma mansoni protein kinase 0.2333 0.2536 0.6241
Echinococcus multilocularis serine threonine protein kinase 0.0552 0.0388 0.0388
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0298 0.0081 0.0081
Entamoeba histolytica protein kinase , putative 0.0557 0.0394 0.3813
Echinococcus granulosus protein kinase C gamma type 0.0552 0.0388 0.0678
Loa Loa (eye worm) hypothetical protein 0.0713 0.0583 0.0792
Schistosoma mansoni protein kinase 0.0351 0.0146 0.0359
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0654 0.0511 0.0893
Loa Loa (eye worm) hypothetical protein 0.0318 0.0106 0.0144
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0351 0.0146 0.0255
Schistosoma mansoni cell adhesion molecule 0.0686 0.055 0.1352
Schistosoma mansoni serine/threonine protein kinase 0.0418 0.0226 0.0557
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.4972 0.5719 1
Trypanosoma brucei cdc2-related kinase 3 0.0418 0.0226 0.0396
Trichomonas vaginalis STE family protein kinase 0.0351 0.0146 0.1326
Schistosoma mansoni atypical protein kinase C 0.0745 0.0621 0.1528
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0236 0.0007 0.0012
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0327 0.0117 0.0204
Trichomonas vaginalis CAMK family protein kinase 0.0402 0.0207 0.1882
Entamoeba histolytica cell division protein kinase 2, putative 0.0418 0.0226 0.2189
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0746 0.0622 0.0622
Schistosoma mansoni serine/threonine-protein kinase 0.0321 0.0109 0.0269
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0516 0.0344 0.3326
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0814 0.0703 0.123
Echinococcus multilocularis casein kinase I alpha 0.0581 0.0423 0.0423
Schistosoma mansoni neuroglian 0.0293 0.0076 0.0186
Brugia malayi Immunoglobulin I-set domain containing protein 0.0293 0.0076 0.0103
Schistosoma mansoni serine/threonine kinase 0.0435 0.0246 0.0607
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0258 0.0033 0.0319
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0786 0.067 0.1171
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0351 0.0146 0.0255
Echinococcus granulosus cyclin dependent kinase 5 0.0418 0.0226 0.0396
Echinococcus granulosus tyrosine protein kinase Fyn 0.1021 0.0953 0.1667
Echinococcus granulosus defective proboscis extension response 0.057 0.041 0.0716
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0516 0.0344 0.0602
Loa Loa (eye worm) hypothetical protein 0.0602 0.0449 0.061
Echinococcus granulosus c src tyrosine kinase 0.0601 0.0447 0.0782
Brugia malayi hypothetical protein 0.0568 0.0407 0.0554
Schistosoma mansoni protein kinase 0.0351 0.0146 0.0359
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0687 0.0551 0.0963
Schistosoma mansoni ephrin receptor 0.0262 0.0039 0.0095
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0036 0.0331
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Echinococcus granulosus N chimaerin 0.0351 0.0146 0.0255
Schistosoma mansoni serine/threonine protein kinase 0.1288 0.1276 0.314
Echinococcus granulosus protein tyrosine kinase 0.36 0.4063 0.7105
Brugia malayi Egg laying defective protein 4 0.0256 0.0031 0.0042
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.2157 0.2324 0.4064
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0256 0.0031 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0236 0.0007 0.0065
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.051 0.0338 0.0459
Entamoeba histolytica protein kinase, putative 0.0679 0.0541 0.5227
Trypanosoma cruzi casein kinase, putative 0.0581 0.0423 0.0739
Entamoeba histolytica protein kinase domain containing protein 0.1088 0.1034 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.0687 0.0551 0.0749
Echinococcus granulosus tyrosine kinase 0.0857 0.0756 0.1321
Entamoeba histolytica protein kinase, putative 0.0233 0.0003 0.0032
Echinococcus granulosus protein kinase shaggy 0.1088 0.1034 0.1809
Entamoeba histolytica protein kinase 2, putative 0.0278 0.0058 0.0562
Trypanosoma cruzi polo-like protein kinase, putative 0.0298 0.0081 0.0142
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0979 0.0903 0.0903
Entamoeba histolytica p21-activated kinase 0.0394 0.0197 0.1905
Echinococcus multilocularis cyclin dependent kinase 7 0.0623 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0513 0.0341 0.0464
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.4972 0.5719 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0516 0.0344 0.3326
Entamoeba histolytica PH domain containing protein kinase, putative 0.0321 0.0109 0.1056
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0383 0.0184 0.0321
Echinococcus multilocularis raf serine:threonine protein kinase 0.0375 0.0174 0.0174
Echinococcus granulosus tyrosine protein kinase Src42A 0.1021 0.0953 0.1667
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.1288 0.1276 0.2231
Echinococcus granulosus serine:threonine protein kinase TAO1 0.2674 0.2947 0.5154
Trichomonas vaginalis CMGC family protein kinase 0.0418 0.0226 0.2056
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0818 0.0709 0.0709
Plasmodium falciparum casein kinase 1 0.0581 0.0423 0.4087
Echinococcus granulosus activin receptor type 0.3784 0.4286 0.7494
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.1021 0.0953 0.1667
Loa Loa (eye worm) CAMK/PIM protein kinase 0.2119 0.2277 0.3096
Brugia malayi Protein kinase domain containing protein 0.0397 0.0201 0.0274
Schistosoma mansoni serine/threonine protein kinase 0.1577 0.1624 0.3997
Plasmodium vivax protein kinase Crk2 0.0418 0.0226 0.2189
Brugia malayi Protein kinase domain containing protein 0.072 0.0591 0.0804
Entamoeba histolytica PH domain containing protein kinase, putative 0.0321 0.0109 0.1056
Onchocerca volvulus 0.0713 0.0583 0.0792
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0286 0.0067 0.0092
Brugia malayi Immunoglobulin I-set domain containing protein 0.0431 0.0243 0.033
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0293 0.0076 0.0132
Brugia malayi Hr1 repeat family protein 0.1577 0.1624 0.2208
Trichomonas vaginalis STE family protein kinase 0.0329 0.0119 0.1083
Brugia malayi Protein kinase domain containing protein 0.1067 0.1009 0.1372
Echinococcus multilocularis c src tyrosine kinase 0.0601 0.0447 0.0447
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.073 0.0603 0.082
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0351 0.0146 0.0146
Schistosoma mansoni serine/threonine protein kinase 0.0979 0.0903 0.2223
Echinococcus multilocularis insulin receptor 0.126 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0293 0.0076 0.0103
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0236 0.0007 0.0007
Echinococcus multilocularis tyrosine protein kinase HCK 0.065 0.0506 0.0506
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.2762 0.3054 0.4152
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0081 0.074
Schistosoma mansoni nephrin 0.0293 0.0076 0.0186
Giardia lamblia Kinase, CMGC CDK 0.0418 0.0226 0.2056
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0273 0.0051 0.0069
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.1143 0.1101 0.1925
Loa Loa (eye worm) CAMK/PKD protein kinase 0.101 0.0941 0.1279
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0315 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0261 0.0037 0.005
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0327 0.0117 0.0159
Echinococcus multilocularis serine:threonine protein kinase 3 0.0381 0.0181 0.0181
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0298 0.0081 0.0111
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0636 0.049 0.0666
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0261 0.0037 0.005
Schistosoma mansoni protein kinase 0.0383 0.0184 0.0452
Echinococcus multilocularis tyrosine protein kinase Fgr 0.1021 0.0953 0.0953
Plasmodium vivax serine/threonine kinase-1, putative 0.0959 0.0879 0.8502
Brugia malayi Protein kinase domain containing protein 0.126 0.1242 0.1689
Schistosoma mansoni serine/threonine protein kinase 0.0557 0.0394 0.0971
Onchocerca volvulus 0.0252 0.0026 0.0035
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0656 0.0513 0.0698
Schistosoma mansoni serine/threonine protein kinase 0.0687 0.0551 0.1355
Brugia malayi Variant SH3 domain containing protein 0.025 0.0024 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0679 0.0541 0.4909
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0601 0.0447 0.11
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0261 0.0036 0.005
Schistosoma mansoni protein kinase 0.0383 0.0184 0.0452
Onchocerca volvulus 0.0316 0.0104 0.0141
Brugia malayi Protein kinase domain containing protein 0.2119 0.2277 0.3096
Echinococcus granulosus neuroglian 0.0747 0.0623 0.109
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0293 0.0076 0.0076
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0687 0.0551 0.0963
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0081 0.074
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0418 0.0226 0.0308
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Brugia malayi P38 map kinase family protein 2 0.4972 0.5719 0.7776
Echinococcus granulosus Vam6:Vps39 protein 0.0633 0.0486 0.085
Echinococcus granulosus cyclin dependent kinase 1 0.0418 0.0226 0.0396
Schistosoma mansoni septate junction protein 0.0261 0.0037 0.0091
Echinococcus granulosus tyrosine kinase 0.0437 0.0249 0.0436
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1088 0.1034 0.1406
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0925 0.0838 0.1466
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0687 0.0551 0.5323
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0959 0.0879 0.1196
Schistosoma mansoni tyrosine kinase 0.209 0.2242 0.5518
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0557 0.0394 0.3813
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0371 0.0169 0.0417
Onchocerca volvulus 0.0633 0.0486 0.0661
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0516 0.0344 0.0602
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0418 0.0226 0.0396
Brugia malayi Stress-activated protein kinase jnk-1 0.2762 0.3054 0.4152
Loa Loa (eye worm) hypothetical protein 0.0516 0.0345 0.0469
Trypanosoma cruzi casein kinase, putative 0.0581 0.0423 0.0739
Onchocerca volvulus 0.0437 0.0249 0.0339
Loa Loa (eye worm) TK/FER protein kinase 0.0437 0.0249 0.0339
Echinococcus granulosus cyclin dependent kinase 19 0.1635 0.1695 0.2963
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0687 0.0551 0.0551
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0756 0.0635 0.111
Onchocerca volvulus 0.0858 0.0757 0.1029
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1067 0.1009 0.1765
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.0066 0.0163
Entamoeba histolytica casein kinase, putative 0.0581 0.0423 0.4087
Brugia malayi Cam kinase protein 1 0.0516 0.0344 0.0468
Echinococcus granulosus beta-adrenergic receptor kinase 0.0285 0.0066 0.0115
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.1067 0.1009 0.1372
Schistosoma mansoni serine/threonine protein kinase 0.0656 0.0513 0.1263
Echinococcus granulosus calcium activated potassium channel 0.0318 0.0106 0.0186
Giardia lamblia Kinase, AGC AKT 0.0931 0.0845 0.767
Trichomonas vaginalis AGC family protein kinase 0.0258 0.0033 0.03
Schistosoma mansoni ephrin receptor 0.0296 0.0079 0.0194
Trichomonas vaginalis AGC family protein kinase 0.0557 0.0394 0.3581
Echinococcus granulosus rho-associated protein kinase 1 0.0755 0.0633 0.1106
Entamoeba histolytica hypothetical protein 0.0233 0.0003 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0679 0.0541 0.4909
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1293 0.1281 0.1281
Loa Loa (eye worm) hypothetical protein 0.057 0.041 0.0557
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0261 0.0036 0.0064
Schistosoma mansoni tyrosine kinase 0.0756 0.0635 0.1562
Plasmodium vivax calcium-dependent protein kinase, putative 0.0516 0.0344 0.3326
Entamoeba histolytica protein kinase, putative 0.1088 0.1034 1
Brugia malayi Serine/threonine-protein kinase SULU 0.2674 0.2947 0.4007
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0359 0.0156 0.1505
Loa Loa (eye worm) AUR protein kinase 0.0557 0.0394 0.0536
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0925 0.0838 0.114
Onchocerca volvulus Serine\/threonine kinase homolog 0.0298 0.0081 0.0111
Loa Loa (eye worm) hypothetical protein 0.0573 0.0413 0.0562
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Schistosoma mansoni serine/threonine protein kinase 0.0418 0.0226 0.0557
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0383 0.0184 0.0321
Trypanosoma brucei polo-like protein kinase 0.0298 0.0081 0.0142
Echinococcus granulosus ephrin type A receptor 4 A 0.0296 0.0079 0.0138
Brugia malayi Protein kinase domain containing protein 0.6329 0.7355 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0285 0.0066 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0959 0.0879 0.2164
Echinococcus granulosus contactin 0.0293 0.0076 0.0132
Leishmania major protein kinase A catalytic subunit 0.0687 0.0551 0.0963
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0484 0.0306 0.0534
Brugia malayi protein-tyrosine kinase 0.0857 0.0756 0.1027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0362 0.0159 0.0216
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.1143 0.1101 0.1497
Brugia malayi Temporarily assigned gene name protein 59 0.0633 0.0486 0.0661
Brugia malayi bone morphogenetic protein type 1 receptor 0.0896 0.0803 0.1092
Schistosoma mansoni protein kinase 0.0383 0.0184 0.0452
Brugia malayi hypothetical protein 0.0437 0.0249 0.0339
Entamoeba histolytica protein kinase, putative 0.0557 0.0394 0.3813
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1088 0.1034 0.1809
Echinococcus granulosus cyclin dependent kinase 0.0418 0.0226 0.0396
Entamoeba histolytica serine/threonine protein kinase, putative 0.0327 0.0117 0.1129
Entamoeba histolytica tyrosin kinase, putative 0.0271 0.0049 0.0477
Echinococcus granulosus dual specificity protein kinase clk2 0.0959 0.0879 0.1538
Brugia malayi Doublecortin family protein 0.0273 0.0051 0.0069
Loa Loa (eye worm) TK/KIN16 protein kinase 0.3201 0.3583 0.4871
Schistosoma mansoni roundabout 0.0261 0.0037 0.0091
Echinococcus multilocularis TGF beta receptor type 1 0.0818 0.0709 0.0709
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0351 0.0146 0.0146
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0516 0.0344 0.3326
Echinococcus granulosus tyrosine protein kinase Srms 0.0853 0.0751 0.1312
Loa Loa (eye worm) hypothetical protein 0.0687 0.0551 0.0749
Echinococcus multilocularis neuroglian 0.0747 0.0623 0.0623
Brugia malayi Protein kinase domain containing protein 0.2026 0.2166 0.2945
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0687 0.0551 0.0963
Echinococcus multilocularis neuroglian 0.0293 0.0076 0.0076
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0516 0.0344 0.0344
Brugia malayi putative serine/threonine kinase SADA gamma 0.0327 0.0117 0.0159
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0633 0.0486 0.085
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.2119 0.2277 0.3096
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.1872 0.198 0.198
Schistosoma mansoni serine/threonine protein kinase 0.1478 0.1505 0.3704
Entamoeba histolytica hypothetical protein 0.0387 0.0189 0.1832
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.2333 0.2536 0.4435
Echinococcus granulosus tyrosine protein kinase Blk 0.0857 0.0756 0.1321
Trichomonas vaginalis CAMK family protein kinase 0.0318 0.0105 0.0957
Entamoeba histolytica protein kinase, putative 0.0372 0.017 0.1647
Loa Loa (eye worm) variant SH3 domain-containing protein 0.025 0.0024 0.0033
Giardia lamblia Kinase, CMGC CLK 0.0959 0.0879 0.7986
Schistosoma mansoni septate junction protein 0.0261 0.0037 0.0091
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1088 0.1034 0.1034
Brugia malayi probable protein kinase 0.1525 0.1561 0.2123
Echinococcus multilocularis mitogen activated protein kinase 11 0.4972 0.5719 0.5719
Echinococcus multilocularis c Jun NH2 terminal kinase 0.2762 0.3054 0.3054
Schistosoma mansoni serine/threonine protein kinase 0.0571 0.0411 0.1011
Schistosoma mansoni serine/threonine protein kinase 0.0323 0.0112 0.0277
Loa Loa (eye worm) hypothetical protein 0.0261 0.0037 0.005
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.1352 0.1353 0.1353
Brugia malayi protein kinase C3,putative 0.0381 0.0182 0.0248
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0036 0.0331
Echinococcus multilocularis tyrosine protein kinase Blk 0.0857 0.0756 0.0756
Entamoeba histolytica protein kinase domain containing protein 0.0383 0.0184 0.1778
Brugia malayi Tyrosine-protein kinase abl-1 0.1254 0.1235 0.1678
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.1143 0.1101 0.1497
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0623 0.0473 0.0828
Brugia malayi Protein kinase domain containing protein 0.0959 0.0879 0.1196
Entamoeba histolytica protein kinase domain containing protein 0.0557 0.0394 0.3813
Trichomonas vaginalis AGC family protein kinase 0.0557 0.0394 0.3581
Trypanosoma cruzi casein kinase, putative 0.0581 0.0423 0.0739
Plasmodium vivax protein kinase, putative 0.0246 0.0019 0.0179
Onchocerca volvulus Serine\/threonine kinase homolog 0.0286 0.0067 0.0092
Entamoeba histolytica protein kinase, putative 0.0372 0.017 0.1647
Schistosoma mansoni serine/threonine protein kinase 0.0521 0.035 0.0862
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0437 0.0249 0.2412
Brugia malayi Immunoglobulin I-set domain containing protein 0.0293 0.0076 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.0327 0.0117 0.0287
Giardia lamblia Kinase, CMGC GSK 0.1088 0.1034 0.9393
Entamoeba histolytica serine/threonine protein kinase, putative 0.0298 0.0081 0.0788
Echinococcus granulosus dual specificity 0.0261 0.0036 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0081 0.074
Echinococcus multilocularis MAM 0.0318 0.0106 0.0106
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0327 0.0117 0.0204
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0371 0.0169 0.023
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0418 0.0226 0.0396
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0278 0.0058 0.0102
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0857 0.0756 0.1321
Loa Loa (eye worm) hypothetical protein 0.073 0.0603 0.082
Loa Loa (eye worm) hypothetical protein 0.0856 0.0755 0.1027
Loa Loa (eye worm) TK/ROR protein kinase 0.0407 0.0214 0.029
Trichomonas vaginalis AGC family protein kinase 0.0234 0.0005 0.0046
Echinococcus granulosus hemicentin 1 0.0261 0.0037 0.0064
Trichomonas vaginalis AGC family protein kinase 0.0679 0.0541 0.4909
Echinococcus granulosus casein kinase I delta 0.0581 0.0423 0.0739
Entamoeba histolytica protein kinase domain containing protein 0.1088 0.1034 1
Echinococcus multilocularis serine:threonine protein kinase 0.0318 0.0105 0.0105
Plasmodium falciparum calcium-dependent protein kinase 4 0.0516 0.0344 0.3326
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0261 0.0037 0.005
Onchocerca volvulus 0.1088 0.1034 0.1406
Echinococcus multilocularis basement membrane specific heparan sulfate 0.057 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0633 0.0486 0.0661
Brugia malayi protein kinase C II. 0.0656 0.0513 0.0698
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1021 0.0953 0.0953
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0857 0.0756 0.0756
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0261 0.0036 0.0353
Schistosoma mansoni tyrosine kinase 0.0601 0.0447 0.11
Echinococcus granulosus cyclin dependent kinase 9 0.0371 0.0169 0.0296
Echinococcus multilocularis casein kinase I alpha 0.0581 0.0423 0.0423
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0323 0.0112 0.0153
Giardia lamblia Kinase, CAMK CAMKL 0.036 0.0156 0.1417
Trichomonas vaginalis STE family protein kinase 0.1143 0.1101 1
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.1143 0.1101 0.1925
Giardia lamblia Kinase, CK1 Casein kinase 0.0581 0.0423 0.3839
Schistosoma mansoni protein kinase 0.0896 0.0803 0.1977
Echinococcus multilocularis tyrosine protein kinase Abl 0.1254 0.1235 0.1235
Trypanosoma cruzi casein kinase, putative 0.0581 0.0423 0.0739
Echinococcus granulosus serine:threonine protein kinase N2 0.1577 0.1624 0.284
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1346 0.1345 0.1345
Echinococcus granulosus NDR protein kinase 0.051 0.0338 0.059
Schistosoma mansoni protein kinase 0.2333 0.2536 0.6241
Trypanosoma brucei SNF1-related protein kinases, putative 0.0327 0.0117 0.0204
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Schistosoma mansoni serine/threonine protein kinase 0.0687 0.0551 0.1355
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0687 0.0551 0.0963
Brugia malayi Protein kinase domain containing protein 0.0679 0.0541 0.0735
Loa Loa (eye worm) hypothetical protein 0.0318 0.0106 0.0144
Echinococcus granulosus peroxidasin 0.0264 0.004 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0623 0.0473 0.1164
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0081 0.074
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Echinococcus multilocularis cyclin dependent kinase 1 0.0418 0.0226 0.0226
Echinococcus granulosus cGMP dependent protein kinase 1 0.0256 0.0031 0.0054
Toxoplasma gondii casein kinase I 0.0581 0.0423 0.4087
Onchocerca volvulus 0.0428 0.0239 0.0325
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1088 0.1034 0.1809
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1021 0.0953 0.0953
Brugia malayi Furin-like cysteine rich region family protein 0.0955 0.0874 0.1188
Onchocerca volvulus 0.0437 0.0249 0.0339
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0321 0.0109 0.0191
Onchocerca volvulus 0.6329 0.7355 1
Schistosoma mansoni serine/threonine protein kinase 0.0325 0.0115 0.0282
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Echinococcus granulosus cyclin dependent kinase 9 0.0338 0.013 0.0227
Echinococcus granulosus titin 0.0362 0.0159 0.0277
Brugia malayi hypothetical protein 0.0602 0.0449 0.061
Echinococcus granulosus serine/threonine protein kinase 0.0321 0.0109 0.0191
Loa Loa (eye worm) TK/FER protein kinase 0.0746 0.0622 0.0846
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0256 0.0031 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Plasmodium falciparum cGMP-dependent protein kinase 0.0256 0.0031 0.0301
Brugia malayi p70 ribosomal S6 kinase beta 0.0636 0.049 0.0666
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.1352 0.1353 0.2365
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0521 0.035 0.0476
Trypanosoma brucei aurora B kinase 0.0557 0.0394 0.069
Onchocerca volvulus 0.2317 0.2517 0.3422
Loa Loa (eye worm) TK protein kinase 0.1529 0.1566 0.213
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0696 0.0562 0.0562
Schistosoma mansoni vesicular amine transporter 0.057 0.041 0.1008
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0338 0.013 0.0177
Echinococcus granulosus tyrosine protein kinase Src64B 0.1021 0.0953 0.1667
Entamoeba histolytica protein kinase domain containing protein 0.0338 0.013 0.1256
Giardia lamblia Kinase, CMGC GSK 0.1088 0.1034 0.9393
Echinococcus multilocularis cyclin dependent kinase 0.0418 0.0226 0.0226
Schistosoma mansoni tyrosine kinase 0.126 0.1242 0.3057
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0397 0.0201 0.0274
Loa Loa (eye worm) hypothetical protein 0.057 0.041 0.0557
Brugia malayi serine/threonine kinase 12 0.0557 0.0394 0.0536
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0484 0.0306 0.0534
Entamoeba histolytica cell division protein kinase 2, putative 0.0451 0.0266 0.2568
Schistosoma mansoni kinase 0.0364 0.0162 0.0398
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.1067 0.1009 0.1765
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0036 0.0331
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.073 0.0603 0.082
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0298 0.0081 0.0142
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0383 0.0184 0.0321
Leishmania major protein kinase, putative 0.0557 0.0394 0.069
Schistosoma mansoni Neurotrimin precursor (hNT) 0.057 0.041 0.1008
Leishmania major protein kinase A catalytic subunit isoform 1 0.0687 0.0551 0.0963
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.051 0.0338 0.0338
Entamoeba histolytica protein kinase, putative 0.051 0.0338 0.3264
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0351 0.0146 0.0198
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1478 0.1505 0.2046
Trichomonas vaginalis AGC family protein kinase 0.0679 0.0541 0.4909
Loa Loa (eye worm) hypothetical protein 0.0516 0.0345 0.0469
Trypanosoma cruzi casein kinase, putative 0.0581 0.0423 0.0739
Schistosoma mansoni kinase 0.0338 0.013 0.032
Loa Loa (eye worm) hypothetical protein 0.0602 0.0449 0.061
Brugia malayi serine/threonine-protein kinase plk-2 0.0298 0.0081 0.0111
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0576 0.0417 0.0567
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0687 0.0551 0.5323
Loa Loa (eye worm) TK/ALK protein kinase 0.4597 0.5266 0.716
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0516 0.0344 0.3326
Brugia malayi Protein kinase domain containing protein 0.0437 0.0249 0.0339
Entamoeba histolytica protein kinase, putative 0.0516 0.0344 0.3326
Schistosoma mansoni serine/threonine protein kinase 0.0484 0.0306 0.0752
Trypanosoma cruzi cdc2-related kinase 3 0.0418 0.0226 0.0396
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.1021 0.0953 0.0953
Echinococcus multilocularis lachesin 0.0261 0.0037 0.0037
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0278 0.0058 0.0562
Brugia malayi cyclin-dependent kinase 9 0.0338 0.013 0.0177
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0521 0.035 0.035
Brugia malayi Protein kinase domain containing protein 0.0576 0.0417 0.0567
Entamoeba histolytica protein kinase, putative 0.1067 0.1009 0.9757
Echinococcus multilocularis epidermal growth factor receptor 0.0955 0.0874 0.0874
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0388 0.019 0.0258
Giardia lamblia Kinase, PLK 0.0298 0.0081 0.074
Giardia lamblia Kinase, AGC PKA 0.0687 0.0551 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0318 0.0106 0.0262
Loa Loa (eye worm) TK/EGFR protein kinase 0.0955 0.0874 0.1188
Loa Loa (eye worm) AUR protein kinase 0.0557 0.0394 0.0536
Brugia malayi Protein kinase domain containing protein 0.364 0.4112 0.559
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0896 0.0803 0.1092
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0261 0.0036 0.0064
Brugia malayi Protein kinase c protein 2 0.0339 0.0131 0.0177
Brugia malayi Protein kinase domain containing protein 0.0437 0.0249 0.0339
Giardia lamblia Kinase, CMGC DYRK 0.0261 0.0036 0.0331
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0428 0.0239 0.0418
Entamoeba histolytica hypothetical protein 0.1067 0.1009 0.9757
Giardia lamblia Kinase, STE STE20 0.1143 0.1101 1
Loa Loa (eye worm) hypothetical protein 0.0807 0.0696 0.0946
Loa Loa (eye worm) AGC/PKG protein kinase 0.0256 0.0031 0.0042
Brugia malayi Serine/threonine-protein kinase Pim-3 0.2119 0.2277 0.3096
Trichomonas vaginalis CAMK family protein kinase 0.0516 0.0344 0.3124
Plasmodium falciparum calcium-dependent protein kinase 5 0.0516 0.0344 0.3326
Brugia malayi Protein kinase domain containing protein 0.0744 0.0619 0.0842
Giardia lamblia Kinase, CMGC CDK 0.0418 0.0226 0.2056
Brugia malayi Fibronectin type III domain containing protein 0.0602 0.0449 0.061
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.1021 0.0953 0.1667
Brugia malayi Peroxidasin 0.0264 0.004 0.0055
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0973 0.0896 0.1566
Echinococcus multilocularis casein kinase I gamma 0.0336 0.0128 0.0128
Brugia malayi Protein kinase domain containing protein 0.1597 0.1648 0.2241
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1067 0.1009 0.1765
Echinococcus multilocularis hemicentin 1 0.0261 0.0037 0.0037
Brugia malayi Protein kinase domain containing protein 0.0418 0.0226 0.0308
Plasmodium falciparum calcium-dependent protein kinase 2 0.0516 0.0344 0.3326
Toxoplasma gondii AGC kinase 0.0687 0.0551 0.5323
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0516 0.0344 0.0468
Brugia malayi Protein kinase domain containing protein 0.051 0.0338 0.0459
Loa Loa (eye worm) hypothetical protein 0.0261 0.0037 0.005
Echinococcus granulosus fibroblast growth factor receptor 4 0.1352 0.1353 0.2365
Giardia lamblia Kinase, NEK 0.0258 0.0033 0.03
Loa Loa (eye worm) hypothetical protein 0.0254 0.0029 0.004
Brugia malayi casein kinase I 0.0581 0.0423 0.0575
Plasmodium vivax casein kinase 1, putative 0.0581 0.0423 0.4087
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0278 0.0058 0.0102
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0351 0.0146 0.0255
Echinococcus multilocularis aurora kinase A 0.0557 0.0394 0.0394
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0418 0.0226 0.2189
Echinococcus granulosus activated cdc42 kinase 1 0.1597 0.1648 0.2882
Onchocerca volvulus 0.0712 0.0581 0.079
Trypanosoma cruzi cdc2-related kinase 1 0.0418 0.0226 0.0396
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2026 0.2166 0.2945
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0925 0.0838 0.0838
Brugia malayi SH2 domain containing protein 0.0746 0.0622 0.0846
Echinococcus granulosus dual specificity mitogen activated protein 0.1143 0.1101 0.1925
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0557 0.0394 0.3813
Plasmodium falciparum protein kinase, putative 0.0383 0.0184 0.1778
Loa Loa (eye worm) TK/FER protein kinase 0.0437 0.0249 0.0339
Giardia lamblia Kinase, STE STE20 0.0351 0.0146 0.1326
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0286 0.0067 0.0118
Loa Loa (eye worm) TK/EPH protein kinase 0.0313 0.01 0.0136
Trichomonas vaginalis CMGC family protein kinase 0.1088 0.1034 0.9393
Loa Loa (eye worm) CAMK/PIM protein kinase 0.2119 0.2277 0.3096
Giardia lamblia Aurora kinase 0.0557 0.0394 0.3581
Brugia malayi Immunoglobulin I-set domain containing protein 0.0293 0.0076 0.0103
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0959 0.0879 0.1538
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0036 0.0331
Loa Loa (eye worm) thyroid receptor interactor 0.0759 0.0637 0.0867
Brugia malayi hypothetical protein 0.2674 0.2947 0.4007
Loa Loa (eye worm) hypothetical protein 0.0633 0.0486 0.0661
Echinococcus granulosus mitogen activated protein kinase 14 0.4972 0.5719 1
Schistosoma mansoni tyrosine kinase 0.0583 0.0426 0.1048
Trichomonas vaginalis AGC family protein kinase 0.0557 0.0394 0.3581
Schistosoma mansoni protein kinase 0.1525 0.1561 0.3843
Echinococcus granulosus dual specificity 0.1067 0.1009 0.1765
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.2119 0.2277 0.3982
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2238 0.2422 0.2422
Loa Loa (eye worm) hypothetical protein 0.1597 0.1648 0.2241
Plasmodium falciparum protein serine/threonine kinase-1 0.0959 0.0879 0.8502
Schistosoma mansoni serine/threonine protein kinase 0.0318 0.0106 0.0262
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0407 0.0214 0.0214
Brugia malayi SRC-1 0.1021 0.0953 0.1296
Entamoeba histolytica hypothetical protein 0.0232 0.0002 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Entamoeba histolytica protein kinase domain containing protein 0.0325 0.0115 0.1109
Schistosoma mansoni serine/threonine protein kinase 0.0298 0.0081 0.0201
Echinococcus multilocularis transfer RNA-Thr 0.1597 0.1648 0.1648
Schistosoma mansoni serine/threonine protein kinase 0.1635 0.1695 0.417
Schistosoma mansoni tyrosine kinase 0.0491 0.0315 0.0774
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0298 0.0081 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0327 0.0117 0.1061
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0642 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0318 0.0106 0.0144
Echinococcus granulosus aurora kinase A 0.0557 0.0394 0.069
Echinococcus granulosus cyclin dependent kinase 7 0.0623 0.0473 0.0827
Brugia malayi intracellular kinase 0.1088 0.1034 0.1406
Echinococcus granulosus Immunoglobulin 0.057 0.041 0.0716
Loa Loa (eye worm) hypothetical protein 0.0654 0.0511 0.0694
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0623 0.0473 0.0643
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0293 0.0076 0.0186
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0278 0.0058 0.0562
Loa Loa (eye worm) TK/FER protein kinase 0.0437 0.0249 0.0339
Echinococcus granulosus slit 2 protein 0.0254 0.0029 0.0051
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2145 0.2309 0.2309
Echinococcus granulosus activated cdc42 kinase 1 0.1597 0.1648 0.2882
Entamoeba histolytica PH domain containing protein kinase, putative 0.0729 0.0602 0.5817
Schistosoma mansoni serine/threonine protein kinase 0.0979 0.0903 0.2223
Schistosoma mansoni titin 0.0261 0.0037 0.0091
Echinococcus multilocularis serine:threonine protein kinase 0.0318 0.0105 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.2762 0.3054 0.7515
Schistosoma mansoni tyrosine kinase 0.1021 0.0953 0.2346
Echinococcus multilocularis protein kinase c iota type 0.0739 0.0614 0.0614
Trichomonas vaginalis CK1 family protein kinase 0.0581 0.0423 0.3839
Giardia lamblia Kinase, NEK 0.0258 0.0033 0.03
Schistosoma mansoni protein kinase 0.0892 0.0798 0.1963
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0534 0.0367 0.0641
Echinococcus multilocularis peroxidasin 0.0264 0.004 0.004
Echinococcus multilocularis hemicentin 1 0.0261 0.0037 0.0037
Echinococcus multilocularis cyclin dependent kinase 5 0.0418 0.0226 0.0226
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0931 0.0845 0.1148
Echinococcus granulosus serine:threonine protein kinase mig 15 0.1373 0.1378 0.2409
Echinococcus granulosus dual specificity 0.0261 0.0036 0.0064
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0959 0.0879 0.8502
Echinococcus multilocularis N chimaerin 0.0351 0.0146 0.0146
Trypanosoma brucei rac serine-threonine kinase, putative 0.0679 0.0541 0.0945
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0327 0.0117 0.0117
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0959 0.0879 0.1538
Schistosoma mansoni tyrosine kinase 0.0814 0.0703 0.1731
Brugia malayi Immunoglobulin I-set domain containing protein 0.0261 0.0037 0.005
Echinococcus multilocularis calcium dependent protein kinase 0.0363 0.016 0.016
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0245 0.0018 0.0032
Echinococcus multilocularis tyrosine protein kinase otk 0.0261 0.0037 0.0037
Brugia malayi Protein kinase domain containing protein 0.0437 0.0249 0.0339
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.2157 0.2324 0.2324
Entamoeba histolytica protein kinase, putative 0.0261 0.0036 0.0353
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.101 0.0941 0.1279
Brugia malayi Immunoglobulin I-set domain containing protein 0.1529 0.1566 0.213
Brugia malayi ephrin receptor 1 precursor 0.0261 0.0037 0.005
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0261 0.0037 0.0037
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0687 0.0551 0.0963
Brugia malayi protein C17H12.11 0.0568 0.0407 0.0554
Brugia malayi EGF-like domain containing protein 0.0254 0.0029 0.004
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0245 0.0018 0.0018
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0261 0.0036 0.005
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0293 0.0076 0.0103
Echinococcus multilocularis cyclin dependent kinase 9 0.0371 0.0169 0.0169
Brugia malayi C1-like domain containing protein 0.101 0.0941 0.1279
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0633 0.0486 0.085
Brugia malayi Fes/CIP4 homology domain containing protein 0.0759 0.0637 0.0867
Schistosoma mansoni tyrosine kinase 0.1021 0.0953 0.2346
Trichomonas vaginalis AGC family protein kinase 0.0553 0.0389 0.3529
Echinococcus multilocularis 0.0892 0.0798 0.0798
Echinococcus granulosus tyrosine protein kinase otk 0.0261 0.0037 0.0064
Brugia malayi Immunoglobulin I-set domain containing protein 0.0261 0.0037 0.005
Leishmania major protein kinase A catalytic subunit isoform 2 0.0687 0.0551 0.0963
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0557 0.0394 0.0394
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0633 0.0486 0.1196
Loa Loa (eye worm) hypothetical protein 0.1373 0.1378 0.1873
Echinococcus granulosus tyrosine protein kinase shark 0.0655 0.0512 0.0895
Echinococcus multilocularis fibroblast growth factor receptor 4 0.1352 0.1353 0.1353
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0623 0.0473 0.0473
Schistosoma mansoni serine/threonine protein kinase 0.0623 0.0473 0.1164
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.1872 0.198 0.3462
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.1021 0.0953 0.0953
Schistosoma mansoni protein kinase 0.2333 0.2536 0.6241
Trichomonas vaginalis STE family protein kinase 0.1143 0.1101 1
Schistosoma mansoni serine/threonine protein kinase 0.0696 0.0562 0.1383
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.1021 0.0953 0.0953
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1021 0.0953 0.0953
Loa Loa (eye worm) TK protein kinase 0.0539 0.0373 0.0507
Trichomonas vaginalis CAMK family protein kinase 0.0236 0.0007 0.0065
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0278 0.0058 0.0058
Schistosoma mansoni protein kinase 0.0557 0.0394 0.0971
Brugia malayi Protein kinase domain containing protein 0.0323 0.0112 0.0153
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.0031 0.0077
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0351 0.0146 0.0255
Onchocerca volvulus Slit protein homolog 0.0254 0.0029 0.004
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.1288 0.1276 0.1276
Plasmodium falciparum serine/threonine protein kinase KIN 0.0327 0.0117 0.1129
Schistosoma mansoni serine/threonine protein kinase 0.0261 0.0036 0.009
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0261 0.0037 0.0091
Echinococcus granulosus tyrosine protein kinase HCK 0.065 0.0506 0.0885
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0036 0.0331
Echinococcus multilocularis serine:threonine protein kinase N2 0.1067 0.1009 0.1009
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0233 0.0003 0.0032
Echinococcus multilocularis mitogen activated protein kinase 14 0.4972 0.5719 0.5719
Entamoeba histolytica protein kinase, putative 0.0351 0.0146 0.1411
Echinococcus multilocularis cyclin dependent kinase 19 0.1635 0.1695 0.1695
Schistosoma mansoni adapter molecule crk 0.0371 0.0169 0.0417
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0633 0.0486 0.1196
Trichomonas vaginalis AGC family protein kinase 0.0679 0.0541 0.4909
Schistosoma mansoni rap gtpase-activating protein 0.0633 0.0486 0.1196
Entamoeba histolytica protein kinase, putative 0.0636 0.049 0.4733
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0746 0.0622 0.1088
Echinococcus granulosus serine:threonine protein kinase 0.0318 0.0105 0.0184
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0396 0.02 0.035
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0285 0.0066 0.009
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0327 0.0117 0.0204
Echinococcus multilocularis tyrosine protein kinase shark 0.0655 0.0512 0.0512
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0484 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0371 0.0169 0.023
Schistosoma mansoni tyrosine kinase 0.0407 0.0213 0.0525
Echinococcus granulosus serine:threonine protein kinase 0.0318 0.0105 0.0184
Echinococcus multilocularis activated cdc42 kinase 1 0.1597 0.1648 0.1648
Loa Loa (eye worm) hypothetical protein 0.0633 0.0486 0.0661
Brugia malayi Protein kinase domain containing protein 0.0286 0.0067 0.0092
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0979 0.0903 0.158
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0362 0.0159 0.0216
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0516 0.0344 0.3326
Echinococcus multilocularis mitogen activated protein kinase 11 0.4972 0.5719 0.5719
Schistosoma mansoni serine/threonine protein kinase 0.0336 0.0128 0.0314
Echinococcus granulosus insulin receptor 0.126 0.1242 0.2172
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0959 0.0879 0.1538
Brugia malayi Immunoglobulin I-set domain containing protein 0.0261 0.0037 0.005
Brugia malayi casein kinase 1, delta 0.0581 0.0423 0.0575
Schistosoma mansoni tyrosine kinase 0.36 0.4063 1
Echinococcus multilocularis roundabout 2 0.0863 0.0763 0.0763
Trichomonas vaginalis STE family protein kinase 0.1143 0.1101 1
Plasmodium falciparum NIMA related kinase 1 0.0258 0.0033 0.0319
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.072 0.0591 0.0804
Brugia malayi hypothetical protein 0.0318 0.0106 0.0144
Loa Loa (eye worm) hypothetical protein 0.0713 0.0583 0.0792
Echinococcus granulosus casein kinase I delta 0.0581 0.0423 0.0739
Brugia malayi serine/threonine-protein kinase 6 0.0557 0.0394 0.0536
Echinococcus granulosus roundabout 2 0.0863 0.0763 0.1334
Trypanosoma brucei casein kinase I, isoform 2 0.0581 0.0423 0.0739
Schistosoma mansoni serine/threonine protein kinase 0.033 0.012 0.0295
Loa Loa (eye worm) hypothetical protein 0.0526 0.0357 0.0485
Trichomonas vaginalis CMGC family protein kinase 0.1088 0.1034 0.9393
Entamoeba histolytica protein kinase, putative 0.0329 0.0119 0.1153
Echinococcus multilocularis casein kinase I delta 0.0581 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0831 0.0724 0.0985
Loa Loa (eye worm) hypothetical protein 0.0516 0.0344 0.0468
Schistosoma mansoni serine/threonine protein kinase 0.2674 0.2947 0.7253
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0581 0.0423 0.0575
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.0031 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.3201 0.3583 0.4871
Schistosoma mansoni nck2/grb4 0.0371 0.0169 0.0417
Echinococcus granulosus roundabout 2 0.0293 0.0076 0.0132
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0925 0.0838 0.114
Trichomonas vaginalis STE family protein kinase 0.0258 0.0033 0.03
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0633 0.0486 0.085
Brugia malayi Protein kinase domain containing protein 0.0318 0.0105 0.0143
Echinococcus multilocularis twitchin 0.033 0.012 0.012
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0036 0.0331
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1088 0.1034 0.1406
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0325 0.0115 0.0156
Echinococcus granulosus serine threonine protein kinase nrc 0.0278 0.0058 0.0102
Loa Loa (eye worm) hypothetical protein 0.0437 0.0249 0.0339
Giardia lamblia Kinase, CAMK CAMKL 0.036 0.0156 0.1417
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.2157 0.2324 0.316
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0325 0.0115 0.0115
Trypanosoma brucei cdc2-related kinase 1 0.0418 0.0226 0.0396
Echinococcus granulosus protein kinase 0.0892 0.0798 0.1395
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.057 0.041 0.1008
Onchocerca volvulus 0.0437 0.0249 0.0339
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0266 0.0044 0.0044
Trichomonas vaginalis CK1 family protein kinase 0.0581 0.0423 0.3839
Loa Loa (eye worm) AGC/PKN protein kinase 0.1577 0.1624 0.2208
Brugia malayi Protein kinase domain containing protein 0.0315 0.0103 0.014
Schistosoma mansoni titin 0.0362 0.0159 0.039
Schistosoma mansoni tyrosine kinase 0.1938 0.2059 0.5068
Echinococcus granulosus c-Jun N-terminal kinases 0.2762 0.3054 0.534
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0327 0.0117 0.0204
Schistosoma mansoni ste20-related kinase 0.0328 0.0118 0.029
Echinococcus granulosus casein kinase I alpha 0.0581 0.0423 0.0739
Schistosoma mansoni hypothetical protein 0.0633 0.0486 0.1196
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0325 0.0115 0.0156
Plasmodium falciparum protein kinase 5 0.0418 0.0226 0.2189

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -6 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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