Detailed information for compound 1052848

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.417 | Formula: C19H22N6O2
  • H donors: 2 H acceptors: 4 LogP: 3.5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C(/c1cccnc1Oc1ccc(cc1)n1cncn1)\NC(CC)(C)C
  • InChi: 1S/C19H22N6O2/c1-4-19(2,3)23-17(24-26)16-6-5-11-21-18(16)27-15-9-7-14(8-10-15)25-13-20-12-22-25/h5-13,26H,4H2,1-3H3,(H,23,24)
  • InChiKey: YQIYBDYNAFOJAU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0878 0.0925 0.0925
Giardia lamblia Kinase, NEK 0.0241 0.0045 0.0368
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0587 0.0523 0.0523
Schistosoma mansoni serine/threonine protein kinase 0.0268 0.0083 0.0216
Echinococcus granulosus protein tyrosine kinase 0.2993 0.3846 0.6508
Echinococcus granulosus titin 0.034 0.0181 0.0307
Echinococcus granulosus defective proboscis extension response 0.055 0.0472 0.0799
Plasmodium falciparum cGMP-dependent protein kinase 0.024 0.0043 0.0376
Echinococcus multilocularis slit 2 protein 0.0246 0.0053 0.0053
Echinococcus granulosus MAM 0.0255 0.0064 0.0108
Trypanosoma cruzi Protein kinase B 0.0299 0.0126 0.0215
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1044 0.1154 0.1411
Trypanosoma brucei SNF1-related protein kinases, putative 0.0309 0.0139 0.0238
Echinococcus multilocularis PAK box P21 Rho binding 0.0296 0.0122 0.0122
Schistosoma mansoni Neurotrimin precursor (hNT) 0.055 0.0472 0.1228
Echinococcus multilocularis peroxidasin 0.0251 0.0058 0.0058
Trichomonas vaginalis CMGC family protein kinase 0.0396 0.0259 0.2098
Trypanosoma brucei aurora B kinase 0.0529 0.0443 0.0757
Echinococcus granulosus roundabout 2 0.0829 0.0858 0.1451
Schistosoma mansoni protein kinase 0.2008 0.2485 0.6462
Echinococcus granulosus serine:threonine protein kinase MARK2 0.039 0.0251 0.0424
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0299 0.0126 0.0215
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.032 0.0154 0.0401
Echinococcus granulosus cyclin dependent kinase 1 0.0396 0.0259 0.0438
Schistosoma mansoni serine/threonine protein kinase 0.039 0.0251 0.0651
Loa Loa (eye worm) hypothetical protein 0.0587 0.0523 0.0639
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0306 0.0135 0.0135
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0554 0.0477 0.0583
Brugia malayi putative serine/threonine kinase SADA gamma 0.0309 0.0139 0.017
Schistosoma mansoni tyrosine kinase 0.1734 0.2108 0.548
Echinococcus multilocularis calcium dependent protein kinase 0.0321 0.0156 0.0156
Brugia malayi Immunoglobulin I-set domain containing protein 0.0279 0.0098 0.0119
Entamoeba histolytica serine/threonine protein kinase, putative 0.0309 0.0139 0.1205
Schistosoma mansoni serine/threonine protein kinase 0.2439 0.308 0.8009
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1424 0.168 0.2053
Entamoeba histolytica casein kinase 1, putative 0.0554 0.0477 0.4133
Brugia malayi Protein kinase domain containing protein 0.3026 0.3892 0.4757
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0248 0.0055 0.0142
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0886 0.0936 0.1145
Echinococcus granulosus insulin receptor 0.1204 0.1375 0.2327
Echinococcus multilocularis mitogen activated protein kinase 11 0.4446 0.5853 0.5853
Echinococcus granulosus casein kinase I gamma 0.0316 0.0149 0.0252
Loa Loa (eye worm) hypothetical protein 0.0684 0.0657 0.0803
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0296 0.0122 0.0149
Loa Loa (eye worm) hypothetical protein 0.0684 0.0657 0.0803
Trichomonas vaginalis STE family protein kinase 0.1101 0.1233 1
Loa Loa (eye worm) hypothetical protein 0.0798 0.0815 0.0996
Echinococcus multilocularis dual specificity 0.0244 0.0049 0.0049
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0529 0.0443 0.3837
Echinococcus multilocularis casein kinase I alpha 0.0554 0.0477 0.0477
Echinococcus multilocularis Immunoglobulin 0.055 0.0472 0.0472
Plasmodium falciparum calcium-dependent protein kinase 1 0.0462 0.0351 0.3041
Brugia malayi Serine/threonine-protein kinase SULU 0.2225 0.2786 0.3405
Echinococcus multilocularis 0.0779 0.0788 0.0788
Loa Loa (eye worm) TK protein kinase 0.0503 0.0407 0.0498
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1044 0.1154 0.1411
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0309 0.0139 0.0238
Loa Loa (eye worm) hypothetical protein 0.0823 0.0849 0.1037
Plasmodium falciparum serine/threonine protein kinase KIN 0.0309 0.0139 0.1205
Schistosoma mansoni protein kinase 0.0554 0.0477 0.124
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0248 0.0055 0.0067
Entamoeba histolytica protein kinase domain containing protein 0.0248 0.0054 0.0472
Echinococcus multilocularis cGMP dependent protein kinase 1 0.024 0.0043 0.0043
Toxoplasma gondii histone kinase SNF1, putative 0.0309 0.0139 0.1205
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.1226 0.1406 0.1406
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0319 0.0153 0.0398
Echinococcus multilocularis transfer RNA-Thr 0.1531 0.1827 0.1827
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0319 0.0153 0.0187
Echinococcus multilocularis mitogen activated protein kinase 14 0.4446 0.5853 0.5853
Brugia malayi C1-like domain containing protein 0.0967 0.1048 0.1281
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0211 0.0004 0.0032
Toxoplasma gondii AGC kinase 0.0595 0.0534 0.4625
Loa Loa (eye worm) hypothetical protein 0.0246 0.0053 0.0064
Trypanosoma cruzi polo-like protein kinase, putative 0.028 0.0098 0.0168
Brugia malayi protein kinase C3,putative 0.036 0.021 0.0257
Entamoeba histolytica PH domain containing protein kinase, putative 0.0696 0.0673 0.5832
Brugia malayi Temporarily assigned gene name protein 59 0.0587 0.0523 0.0639
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0587 0.0523 0.0884
Giardia lamblia Kinase, CAMK CAMKL 0.034 0.0182 0.1479
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0587 0.4757
Loa Loa (eye worm) hypothetical protein 0.0587 0.0523 0.0639
Brugia malayi Furin-like cysteine rich region family protein 0.0906 0.0963 0.1177
Giardia lamblia Kinase, AGC PKA 0.0261 0.0073 0.0591
Brugia malayi Fibronectin type III domain containing protein 0.0581 0.0515 0.063
Loa Loa (eye worm) hypothetical protein 0.0475 0.0369 0.045
Brugia malayi Protein kinase c protein 2 0.032 0.0154 0.0188
Brugia malayi serine/threonine-protein kinase plk-2 0.028 0.0098 0.012
Schistosoma mansoni serine/threonine protein kinase 0.1451 0.1716 0.4461
Brugia malayi Protein kinase domain containing protein 0.0376 0.0232 0.0283
Schistosoma mansoni growth factor receptor-bound protein 0.0335 0.0174 0.0454
Echinococcus granulosus tyrosine protein kinase shark 0.0596 0.0536 0.0906
Brugia malayi Immunoglobulin I-set domain containing protein 0.0414 0.0284 0.0347
Schistosoma mansoni serine/threonine protein kinase 0.0309 0.0139 0.0362
Echinococcus multilocularis serine:threonine protein kinase 0.026 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0248 0.0055 0.0067
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0517 0.0426 0.0426
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0828 0.0856 0.1047
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1296 0.1502 0.1836
Echinococcus granulosus Vam6:Vps39 protein 0.0587 0.0523 0.0884
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0657 0.062 0.0758
Schistosoma mansoni titin 0.0248 0.0055 0.0142
Echinococcus multilocularis cyclin dependent kinase 7 0.0522 0.0433 0.0433
Giardia lamblia Kinase, CMGC CLK 0.092 0.0982 0.7966
Schistosoma mansoni protein kinase 0.2052 0.2547 0.6622
Trichomonas vaginalis STE family protein kinase 0.1101 0.1233 1
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0657 0.062 0.106
Echinococcus granulosus fibroblast growth factor receptor 4 0.1289 0.1493 0.2527
Schistosoma mansoni tyrosine kinase 0.0596 0.0536 0.1393
Trichomonas vaginalis CMGC family protein kinase 0.092 0.0982 0.7966
Schistosoma mansoni tyrosine kinase 0.0562 0.0489 0.1271
Onchocerca volvulus 0.0579 0.0512 0.0626
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.164 0.1977 0.3346
Trichomonas vaginalis STE family protein kinase 0.0241 0.0045 0.0368
Schistosoma mansoni serine/threonine-protein kinase 0.0299 0.0126 0.0327
Giardia lamblia Aurora kinase 0.0529 0.0443 0.3591
Loa Loa (eye worm) hypothetical protein 0.0255 0.0064 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.092 0.0982 0.2554
Loa Loa (eye worm) variant SH3 domain-containing protein 0.022 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0509 0.0415 0.0508
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0317 0.0151 0.0255
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0886 0.0936 0.0936
Trypanosoma brucei rac serine-threonine kinase, putative 0.0633 0.0587 0.1002
Echinococcus multilocularis lachesin 0.0248 0.0055 0.0055
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0306 0.0135 0.0165
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0878 0.0925 0.0925
Loa Loa (eye worm) gastrulation defective protein 1 0.131 0.1521 0.1859
Loa Loa (eye worm) hypothetical protein 0.084 0.0872 0.1066
Onchocerca volvulus 0.0389 0.0249 0.0304
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0049 0.0399
Loa Loa (eye worm) hypothetical protein 0.0509 0.0415 0.0508
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0055 0.0067
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0692 0.0668 0.0817
Trichomonas vaginalis CAMK family protein kinase 0.028 0.0098 0.0798
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0967 0.1048 0.1281
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0248 0.0055 0.0067
Brugia malayi Stress-activated protein kinase jnk-1 0.2439 0.308 0.3765
Plasmodium falciparum NIMA related kinase 1 0.0241 0.0045 0.0394
Brugia malayi cyclin-dependent kinase 7 homolog 0.0553 0.0476 0.0582
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1424 0.168 0.2053
Echinococcus multilocularis hemicentin 1 0.0248 0.0055 0.0055
Echinococcus multilocularis dual specificity protein kinase clk2 0.092 0.0982 0.0982
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.2008 0.2485 0.4206
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0396 0.0259 0.0442
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0334 0.0173 0.1403
Schistosoma mansoni septate junction protein 0.0248 0.0055 0.0142
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0221 0.0017 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0049 0.0399
Schistosoma mansoni nephrin 0.0749 0.0746 0.1941
Echinococcus multilocularis epidermal growth factor receptor 0.0906 0.0963 0.0963
Echinococcus granulosus tyrosine protein kinase otk 0.0248 0.0055 0.0093
Schistosoma mansoni protein kinase 0.0529 0.0443 0.1151
Toxoplasma gondii AGC kinase 0.0657 0.062 0.5374
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0049 0.0399
Schistosoma mansoni serine/threonine protein kinase 0.072 0.0707 0.1839
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0931 0.0998 0.1705
Entamoeba histolytica protein kinase, putative 0.0335 0.0174 0.151
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0587 0.0523 0.1359
Loa Loa (eye worm) CMGC/CLK protein kinase 0.092 0.0982 0.1201
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0268 0.0083 0.0101
Schistosoma mansoni septate junction protein 0.0248 0.0055 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0221 0.0017 0.0139
Echinococcus granulosus cGMP dependent protein kinase 0.024 0.0043 0.0073
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0587 0.0523 0.0893
Trichomonas vaginalis CAMK family protein kinase 0.028 0.0098 0.0798
Echinococcus granulosus activated cdc42 kinase 1 0.1531 0.1827 0.3091
Schistosoma mansoni tyrosine kinase 0.0456 0.0342 0.089
Brugia malayi Protein kinase domain containing protein 0.1451 0.1716 0.2097
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Echinococcus granulosus roundabout 2 0.0279 0.0098 0.0165
Schistosoma mansoni protein kinase C mu 0.0967 0.1048 0.2725
Entamoeba histolytica hypothetical protein 0.021 0.0003 0.0023
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0376 0.0232 0.0283
Echinococcus granulosus contactin 0.0279 0.0098 0.0165
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0304 0.0132 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.028 0.0098 0.0168
Trypanosoma cruzi aurora B kinase, putative 0.0529 0.0443 0.0757
Brugia malayi p70 ribosomal S6 kinase beta 0.0595 0.0534 0.0652
Schistosoma mansoni serine/threonine protein kinase 0.0573 0.0503 0.1308
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1044 0.1154 1
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0443 0.3591
Plasmodium vivax protein kinase Crk2 0.0396 0.0259 0.2242
Loa Loa (eye worm) AGC/PKG protein kinase 0.024 0.0043 0.0053
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0256 0.0065 0.008
Echinococcus granulosus calcium activated potassium channel 0.027 0.0086 0.0145
Schistosoma mansoni tyrosine kinase 0.0562 0.0489 0.1271
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0914 0.0974 0.0974
Loa Loa (eye worm) hypothetical protein 0.0687 0.0662 0.0809
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1944 0.2397 0.2929
Schistosoma mansoni serine/threonine protein kinase 0.1466 0.1737 0.4515
Brugia malayi Immunoglobulin I-set domain containing protein 0.1457 0.1724 0.2108
Brugia malayi Protein kinase domain containing protein 0.0389 0.0249 0.0304
Entamoeba histolytica protein kinase domain containing protein 0.0319 0.0153 0.1329
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0517 0.0426 0.072
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0319 0.0153 0.0188
Schistosoma mansoni serine/threonine protein kinase 0.0396 0.0259 0.0673
Loa Loa (eye worm) AUR protein kinase 0.0529 0.0443 0.0541
Giardia lamblia Kinase, STE STE20 0.1101 0.1233 1
Echinococcus multilocularis cyclin dependent kinase 9 0.0351 0.0197 0.0197
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0878 0.0925 0.0925
Entamoeba histolytica PH domain containing protein kinase, putative 0.0696 0.0673 0.5832
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0657 0.062 0.5374
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.039 0.0251 0.0251
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.1796 0.2192 0.2679
Echinococcus granulosus serine:threonine protein kinase N2 0.0901 0.0957 0.162
Schistosoma mansoni serine/threonine protein kinase 0.027 0.0086 0.0223
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1884 0.2314 0.2828
Schistosoma mansoni tyrosine kinase 0.0528 0.0442 0.1149
Trichomonas vaginalis CMGC family protein kinase 0.1044 0.1154 0.936
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0279 0.0098 0.0254
Brugia malayi Protein kinase domain containing protein 0.026 0.0072 0.0088
Loa Loa (eye worm) TK/EGFR protein kinase 0.0906 0.0963 0.1177
Loa Loa (eye worm) TK/ABL protein kinase 0.2041 0.2531 0.3094
Entamoeba histolytica protein kinase domain containing protein 0.1026 0.1129 0.9778
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1884 0.2314 0.3916
Brugia malayi Hr1 repeat family protein 0.1376 0.1613 0.1971
Loa Loa (eye worm) TK protein kinase 0.1457 0.1724 0.2108
Brugia malayi hypothetical protein 0.0581 0.0515 0.063
Schistosoma mansoni serine/threonine protein kinase 0.0522 0.0433 0.1126
Plasmodium vivax casein kinase 1, putative 0.0554 0.0477 0.4133
Brugia malayi P38 map kinase family protein 2 0.4446 0.5853 0.7154
Onchocerca volvulus Slit protein homolog 0.0246 0.0053 0.0064
Echinococcus granulosus rho-associated protein kinase 1 0.072 0.0707 0.1197
Onchocerca volvulus 0.2234 0.2798 0.342
Trypanosoma cruzi cdc2-related kinase 3 0.0396 0.0259 0.0442
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0248 0.0055 0.0067
Echinococcus multilocularis dual specificity 0.1026 0.1129 0.1129
Echinococcus multilocularis cyclin dependent kinase 1 0.0396 0.0259 0.0259
Trichomonas vaginalis STE family protein kinase 0.0317 0.0151 0.1222
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0055 0.0067
Brugia malayi Immunoglobulin I-set domain containing protein 0.3073 0.3957 0.4837
Echinococcus granulosus cyclin dependent kinase 7 0.0522 0.0433 0.0733
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0852 0.0889 0.1086
Echinococcus granulosus tyrosine protein kinase Fyn 0.0878 0.0925 0.1565
Brugia malayi Protein kinase domain containing protein 0.0475 0.0368 0.045
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1884 0.2314 0.2828
Plasmodium falciparum calcium-dependent protein kinase 5 0.0462 0.0351 0.3041
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0043 0.0113
Echinococcus multilocularis tyrosine protein kinase Srms 0.0738 0.0732 0.0732
Trichomonas vaginalis STE family protein kinase 0.1101 0.1233 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0462 0.0351 0.3041
Brugia malayi Protein kinase domain containing protein 0.0389 0.0249 0.0304
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0049 0.0399
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1026 0.1129 0.1928
Trichomonas vaginalis CAMK family protein kinase 0.0311 0.0142 0.1148
Echinococcus multilocularis activated cdc42 kinase 1 0.1531 0.1827 0.1827
Trypanosoma brucei casein kinase I, isoform 2 0.0554 0.0477 0.0815
Leishmania major protein kinase, putative 0.092 0.0982 0.1678
Echinococcus granulosus epidermal growth factor receptor 0.0906 0.0963 0.1629
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.025 0.0057 0.0097
Brugia malayi Protein kinase domain containing protein 0.0692 0.0668 0.0817
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0304
Entamoeba histolytica casein kinase, putative 0.0554 0.0477 0.4133
Echinococcus multilocularis cGMP dependent protein kinase 1 0.024 0.0043 0.0043
Trichomonas vaginalis CK1 family protein kinase 0.0554 0.0477 0.3868
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1296 0.1502 0.1836
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0241 0.0045 0.0394
Brugia malayi hypothetical protein 0.0255 0.0064 0.0078
Entamoeba histolytica protein kinase domain containing protein 0.0244 0.0049 0.0427
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0657 0.062 0.105
Plasmodium vivax calcium-dependent protein kinase, putative 0.0462 0.0351 0.3041
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0462 0.0351 0.06
Entamoeba histolytica protein kinase, putative 0.0462 0.0351 0.3041
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0462 0.0351 0.0351
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0657 0.062 0.106
Brugia malayi Protein kinase domain containing protein 0.035 0.0196 0.024
Schistosoma mansoni cell adhesion molecule 0.0279 0.0098 0.0254
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0545 0.0465 0.0568
Entamoeba histolytica protein kinase , putative 0.0529 0.0443 0.3837
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.069 0.0665 0.0813
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0657 0.062 0.105
Echinococcus granulosus casein kinase I delta 0.0554 0.0477 0.0807
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0279 0.0098 0.0165
Loa Loa (eye worm) hypothetical protein 0.0549 0.047 0.0575
Trypanosoma cruzi casein kinase, putative 0.0554 0.0477 0.0815
Trichomonas vaginalis STE family protein kinase 0.0317 0.0151 0.1222
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0587 0.4757
Loa Loa (eye worm) AGC/PKN protein kinase 0.1376 0.1613 0.1971
Brugia malayi Cam kinase protein 1 0.0462 0.0351 0.0429
Schistosoma mansoni protein kinase 0.0317 0.0151 0.0392
Brugia malayi Protein kinase domain containing protein 0.0389 0.0249 0.0304
Loa Loa (eye worm) hypothetical protein 0.0448 0.0332 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.092 0.0982 0.2554
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0049 0.0399
Trypanosoma brucei cdc2-related kinase 1 0.0396 0.0259 0.0442
Entamoeba histolytica protein kinase, putative 0.0464 0.0353 0.3055
Entamoeba histolytica protein kinase, putative 0.0475 0.0368 0.3187
Loa Loa (eye worm) TK/ALK protein kinase 0.3992 0.5226 0.6388
Echinococcus granulosus neuroglian 0.0279 0.0098 0.0165
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0359 0.0207 0.0254
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0657 0.062 0.062
Trypanosoma brucei polo-like protein kinase 0.028 0.0098 0.0168
Loa Loa (eye worm) SRC-1 0.0878 0.0925 0.113
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.1026 0.1129 0.138
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0492 0.0392 0.0479
Brugia malayi hypothetical protein 0.0549 0.047 0.0575
Schistosoma mansoni hypothetical protein 0.0255 0.0064 0.0166
Trichomonas vaginalis STE family protein kinase 0.0317 0.0151 0.1222
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1044 0.1154 0.1972
Brugia malayi Protein kinase domain containing protein 0.092 0.0982 0.1201
Trichomonas vaginalis CMGC family protein kinase 0.0396 0.0259 0.2098
Echinococcus granulosus tyrosine protein kinase Src64B 0.0878 0.0925 0.1565
Onchocerca volvulus 0.0389 0.0249 0.0304
Brugia malayi Protein kinase domain containing protein 0.0395 0.0258 0.0316
Giardia lamblia Kinase, CK1 Casein kinase 0.0554 0.0477 0.3868
Brugia malayi Egg laying defective protein 4 0.024 0.0043 0.0053
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0279 0.0098 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Giardia lamblia Kinase, NEK 0.0241 0.0045 0.0368
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0587 0.0523 0.0893
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1296 0.1502 0.1502
Echinococcus granulosus protein kinase c iota type 0.0694 0.0671 0.1135
Schistosoma mansoni ephrin receptor 0.024 0.0043 0.0112
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0317 0.0151 0.0151
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Schistosoma mansoni protein kinase 0.0296 0.0122 0.0316
Echinococcus multilocularis tyrosine protein kinase HCK 0.0558 0.0483 0.0483
Brugia malayi Variant SH3 domain containing protein 0.032 0.0154 0.0188
Onchocerca volvulus 0.6132 0.8181 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0299 0.0126 0.1089
Brugia malayi Protein kinase domain containing protein 0.0304 0.0132 0.0162
Onchocerca volvulus 0.0389 0.0249 0.0304
Schistosoma mansoni tyrosine kinase 0.1204 0.1375 0.3576
Giardia lamblia Kinase, CMGC GSK 0.1044 0.1154 0.936
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0317 0.0151 0.0151
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0545 0.0464 0.0464
Leishmania major protein kinase, putative 0.092 0.0982 0.1678
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0317 0.0151 0.0151
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.2052 0.2547 0.2547
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0492 0.0392 0.0663
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0529 0.0443 0.0749
Leishmania major protein kinase A catalytic subunit isoform 1 0.0657 0.062 0.106
Brugia malayi probable protein kinase 0.1383 0.1622 0.1983
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.1026 0.1129 0.1928
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0244 0.0049 0.0084
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.042 0.0292 0.0357
Entamoeba histolytica protein kinase, putative 0.0335 0.0174 0.151
Onchocerca volvulus 0.0413 0.0282 0.0345
Entamoeba histolytica protein kinase, putative 0.0529 0.0443 0.3837
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0366 0.0218 0.0267
Brugia malayi serine/threonine kinase 12 0.0529 0.0443 0.0541
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0784 0.0795 0.0795
Echinococcus granulosus dual specificity protein kinase clk2 0.092 0.0982 0.1662
Trypanosoma cruzi casein kinase, putative 0.0554 0.0477 0.0815
Echinococcus granulosus hemicentin 1 0.0248 0.0055 0.0093
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0631 0.0583 0.0987
Brugia malayi Immunoglobulin I-set domain containing protein 0.0581 0.0515 0.063
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0529 0.0443 0.3837
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0244 0.0049 0.0084
Brugia malayi Protein kinase domain containing protein 0.0475 0.0368 0.045
Trichomonas vaginalis CAMK family protein kinase 0.028 0.0098 0.0798
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.1026 0.1129 0.1928
Entamoeba histolytica protein kinase, putative 0.1044 0.1154 1
Onchocerca volvulus 0.0554 0.0477 0.0583
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.1101 0.1233 0.1507
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.1101 0.1233 0.1507
Echinococcus granulosus NCK adaptor protein 0.032 0.0154 0.0261
Echinococcus granulosus serine/threonine protein kinase 0.0299 0.0126 0.0213
Echinococcus granulosus Immunoglobulin 0.055 0.0472 0.0799
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.034 0.0181 0.0222
Echinococcus multilocularis twitchin 0.0308 0.0138 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0309 0.0139 0.0362
Giardia lamblia Kinase, AGC PKA 0.0657 0.062 0.503
Loa Loa (eye worm) hypothetical protein 0.1242 0.1428 0.1745
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0462 0.0351 0.0594
Brugia malayi Protein kinase domain containing protein 0.2052 0.2547 0.3113
Echinococcus multilocularis tyrosine protein kinase Abl 0.116 0.1314 0.1314
Schistosoma mansoni protein kinase 0.0852 0.0889 0.231
Echinococcus multilocularis cyclin dependent kinase 19 0.1451 0.1716 0.1716
Echinococcus granulosus casein kinase I alpha 0.0554 0.0477 0.0807
Schistosoma mansoni ste20-related kinase 0.0308 0.0138 0.0359
Trichomonas vaginalis CAMK family protein kinase 0.028 0.0098 0.0798
Toxoplasma gondii AGC kinase 0.0657 0.062 0.5374
Brugia malayi Protein kinase domain containing protein 0.0633 0.0587 0.0717
Loa Loa (eye worm) hypothetical protein 0.0581 0.0515 0.063
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.025 0.0057 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.026 0.0072 0.0582
Brugia malayi Immunoglobulin I-set domain containing protein 0.034 0.0181 0.0222
Trypanosoma brucei protein kinase, putative 0.0222 0.0018 0.0031
Echinococcus granulosus casein kinase i 0.0554 0.0477 0.0807
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0528 0.0442 0.1149
Loa Loa (eye worm) AUR protein kinase 0.0529 0.0443 0.0541
Echinococcus granulosus roundabout 2 0.0279 0.0098 0.0165
Trichomonas vaginalis CMGC family protein kinase 0.1044 0.1154 0.936
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Schistosoma mansoni serine/threonine protein kinase 0.027 0.0086 0.0223
Brugia malayi Protein kinase domain containing protein 0.0396 0.0259 0.0316
Brugia malayi map kinase activated protein kinase protein 2 0.0492 0.0392 0.0479
Loa Loa (eye worm) hypothetical protein 0.0389 0.0249 0.0304
Schistosoma mansoni hypothetical protein 0.0255 0.0064 0.0166
Echinococcus multilocularis titin 0.034 0.0181 0.0181
Schistosoma mansoni serine/threonine protein kinase 0.0309 0.0139 0.0362
Loa Loa (eye worm) hypothetical protein 0.0248 0.0055 0.0067
Echinococcus multilocularis neuroglian 0.0279 0.0098 0.0098
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.028 0.0098 0.012
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0219 0.0015 0.0019
Echinococcus multilocularis tyrosine protein kinase otk 0.0248 0.0055 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0587 0.4757
Echinococcus multilocularis casein kinase I alpha 0.0554 0.0477 0.0477
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0376 0.0231 0.0391
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.069 0.0665 0.0813
Echinococcus multilocularis TGF beta receptor type 1 0.0784 0.0795 0.0795
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0796 0.0812 0.0993
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0462 0.0351 0.3041
Schistosoma mansoni rap gtpase-activating protein 0.0587 0.0523 0.1359
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0261 0.0073 0.0632
Brugia malayi serine/threonine-protein kinase PAK 7 0.1796 0.2192 0.2679
Schistosoma mansoni atypical protein kinase C 0.07 0.0679 0.1765
Loa Loa (eye worm) AGC/PKA protein kinase 0.0657 0.062 0.0758
Loa Loa (eye worm) hypothetical protein 0.0248 0.0055 0.0067
Echinococcus multilocularis epidermal growth factor receptor 0.0771 0.0777 0.0777
Trichomonas vaginalis AGC family protein kinase 0.0475 0.0368 0.2983
Schistosoma mansoni serine/threonine protein kinase 0.0653 0.0614 0.1597
Echinococcus granulosus hypothetical protein 0.0779 0.0788 0.1333
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0317 0.0151 0.0255
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0223 0.002 0.0034
Brugia malayi protein unc-22 0.034 0.0181 0.0222
Echinococcus granulosus tyrosine protein kinase Srms 0.0785 0.0796 0.1348
Echinococcus granulosus serine:threonine protein kinase PLK1 0.028 0.0098 0.0166
Echinococcus multilocularis serine:threonine protein kinase N2 0.1376 0.1613 0.1613
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.2052 0.2547 0.431
Echinococcus multilocularis serine:threonine protein kinase 3 0.0359 0.0207 0.0207
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.164 0.1977 0.1977
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1884 0.2314 0.2828
Onchocerca volvulus 0.1044 0.1154 0.1411
Schistosoma mansoni protein kinase 0.1383 0.1622 0.4218
Schistosoma mansoni tyrosine kinase 0.0878 0.0925 0.2404
Loa Loa (eye worm) hypothetical protein 0.0248 0.0055 0.0067
Schistosoma mansoni protein kinase 0.0349 0.0195 0.0506
Schistosoma mansoni protein kinase 0.1101 0.1233 0.3206
Brugia malayi Tyrosine-protein kinase abl-1 0.116 0.1314 0.1607
Schistosoma mansoni tyrosine kinase 0.0562 0.0489 0.1271
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0886 0.0936 0.1145
Schistosoma mansoni protein kinase 0.0349 0.0195 0.0506
Echinococcus granulosus TGF-beta receptor type-1 0.0784 0.0795 0.1346
Brugia malayi EGF-like domain containing protein 0.0246 0.0053 0.0064
Schistosoma mansoni serine/threonine-protein kinase 0.0299 0.0126 0.0327
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0244 0.0049 0.0427
Schistosoma mansoni tyrosine kinase 0.1289 0.1493 0.3882
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.2439 0.308 0.3765
Echinococcus multilocularis mitogen activated protein kinase 14 0.4446 0.5853 0.5853
Echinococcus granulosus tyrosine protein kinase Src42A 0.0545 0.0464 0.0786
Schistosoma mansoni tyrosine kinase 0.0416 0.0287 0.0745
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0657 0.062 0.5374
Brugia malayi Protein kinase domain containing protein 0.6132 0.8181 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0269 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0885 0.0934 0.1142
Brugia malayi Doublecortin family protein 0.0256 0.0065 0.008
Schistosoma mansoni cell adhesion molecule 0.0279 0.0098 0.0254
Plasmodium falciparum protein kinase, putative 0.0349 0.0195 0.1687
Echinococcus granulosus ephrin type A receptor 4 A 0.0271 0.0086 0.0145
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0389 0.0249 0.2158
Brugia malayi bone morphogenetic protein type 1 receptor 0.0852 0.0889 0.1086
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0587 0.0523 0.1359
Echinococcus granulosus protein kinase 0.0796 0.0812 0.1374
Echinococcus multilocularis dual specificity mitogen activated protein 0.1101 0.1233 0.1233
Entamoeba histolytica protein kinase, putative 0.0321 0.0156 0.1352
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0304
Brugia malayi intracellular kinase 0.1044 0.1154 0.1411
Loa Loa (eye worm) AUR protein kinase 0.0529 0.0443 0.0541
Leishmania major protein kinase, putative 0.0349 0.0195 0.0333
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0396 0.0259 0.0442
Echinococcus multilocularis protein tyrosine kinase 0.2993 0.3846 0.3846
Schistosoma mansoni tyrosine kinase 0.0878 0.0925 0.2404
Loa Loa (eye worm) hypothetical protein 0.0255 0.0064 0.0078
Onchocerca volvulus 0.0255 0.0064 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Echinococcus multilocularis casein kinase i 0.0554 0.0477 0.0477
Echinococcus multilocularis serine:threonine protein kinase 0.026 0.0072 0.0072
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0475 0.0368 0.0622
Brugia malayi Protein kinase domain containing protein 0.1026 0.1129 0.138
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.026 0.0072 0.0088
Schistosoma mansoni protein kinase 0.0796 0.0812 0.2111
Loa Loa (eye worm) hypothetical protein 0.0718 0.0703 0.086
Echinococcus multilocularis c src tyrosine kinase 0.0528 0.0442 0.0442
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0587 0.4757
Entamoeba histolytica hypothetical protein 0.0211 0.0004 0.0032
Schistosoma mansoni ephrin receptor 0.0271 0.0086 0.0223
Loa Loa (eye worm) hypothetical protein 0.0631 0.0583 0.0713
Brugia malayi Tyrosine-protein kinase abl-1 0.102 0.1122 0.1371
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0878 0.0925 0.0925
Trypanosoma cruzi polo-like protein kinase, putative 0.028 0.0098 0.0168
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0241 0.0045 0.0394
Giardia lamblia Kinase, CMGC GSK 0.1044 0.1154 0.936
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0475 0.0368 0.045
Echinococcus multilocularis rho associated protein kinase 0.072 0.0707 0.0707
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1235 0.1418 0.1418
Brugia malayi serine/threonine protein kinase 6 0.0529 0.0443 0.0541
Brugia malayi Prion-like- 0.0248 0.0055 0.0067
Brugia malayi Protein kinase domain containing protein 0.0545 0.0465 0.0568
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0279 0.0098 0.0098
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0306 0.0135 0.0165
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0878 0.0925 0.0925
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0522 0.0433 0.053
Brugia malayi hypothetical protein 0.2225 0.2786 0.3405
Loa Loa (eye worm) variant SH3 domain-containing protein 0.032 0.0154 0.0188
Onchocerca volvulus 0.0389 0.0249 0.0304
Loa Loa (eye worm) hypothetical protein 0.0309 0.0139 0.017
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0657 0.062 0.106
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0279 0.0098 0.0098
Echinococcus granulosus tyrosine protein kinase Src42A 0.0878 0.0925 0.1565
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0878 0.0925 0.0925
Schistosoma mansoni serine/threonine protein kinase 0.0657 0.062 0.1613
Loa Loa (eye worm) hypothetical protein 0.0248 0.0055 0.0067
Echinococcus multilocularis protein kinase shaggy 0.1044 0.1154 0.1154
Brugia malayi cell division control protein 2 homolog 0.0396 0.0259 0.0316
Onchocerca volvulus 0.0587 0.0523 0.0639
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.4446 0.5853 1
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0304
Giardia lamblia Kinase, CAMK CAMKL 0.034 0.0182 0.1479
Schistosoma mansoni tyrosine kinase 0.186 0.2282 0.5933
Entamoeba histolytica protein kinase, putative 0.0529 0.0443 0.3837
Echinococcus granulosus activated cdc42 kinase 1 0.1531 0.1827 0.3091
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0653 0.0614 0.0614
Onchocerca volvulus 0.072 0.0707 0.0864
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0396 0.0259 0.2242
Echinococcus granulosus casein kinase I alpha 0.0554 0.0477 0.0807
Leishmania major protein kinase, putative 0.0462 0.0351 0.06
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0396 0.0259 0.0316
Echinococcus multilocularis serine:threonine protein kinase 38 0.0475 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0581 0.0515 0.063
Onchocerca volvulus Tyrosine kinase homolog 0.261 0.3317 0.4055
Echinococcus granulosus serine:threonine protein kinase MARK2 0.039 0.0251 0.0424
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0304
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.0084 0.0219
Loa Loa (eye worm) hypothetical protein 0.0279 0.0098 0.0119
Echinococcus multilocularis MAM 0.0255 0.0064 0.0064
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0589 0.0526 0.0891
Trichomonas vaginalis AGC family protein kinase 0.0219 0.0015 0.0124
Echinococcus granulosus c-Jun N-terminal kinases 0.2439 0.308 0.5213
Echinococcus multilocularis insulin receptor 0.1204 0.1375 0.1375
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0268 0.0083 0.0083
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0914 0.0974 0.1648
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0279 0.0098 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.0192 0.0498
Brugia malayi hypothetical protein 0.0587 0.0523 0.0639
Echinococcus granulosus dual specificity 0.0244 0.0049 0.0083
Entamoeba histolytica protein kinase domain containing protein 0.0306 0.0135 0.1167
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.1101 0.1233 0.2107
Brugia malayi Immunoglobulin I-set domain containing protein 0.0279 0.0098 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0914 0.0974 0.2533
Plasmodium vivax protein kinase, putative 0.0223 0.002 0.0175
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0587 0.4757
Brugia malayi ephrin receptor 1 precursor 0.0238 0.004 0.005
Plasmodium falciparum serine/threonine protein kinase, putative 0.0529 0.0443 0.3837
Trichomonas vaginalis AGC family protein kinase 0.0657 0.062 0.503
Schistosoma mansoni serine/threonine protein kinase 0.0615 0.0561 0.1459
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.092 0.0982 0.851
Loa Loa (eye worm) hypothetical protein 0.0885 0.0934 0.1142
Brugia malayi Protein kinase domain containing protein 0.1204 0.1375 0.1681
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0244 0.0049 0.006
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0349 0.0195 0.0333
Brugia malayi Protein kinase domain containing protein 0.1884 0.2314 0.2828
Onchocerca volvulus Serine\/threonine kinase homolog 0.028 0.0098 0.012
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0261 0.0073 0.0632
Brugia malayi Protein kinase domain containing protein 0.0705 0.0686 0.0839
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0349 0.0195 0.0333
Trypanosoma cruzi casein kinase, putative 0.0554 0.0477 0.0815
Echinococcus granulosus dual specificity 0.0244 0.0049 0.0083
Echinococcus granulosus serine:threonine protein kinase 3 0.0359 0.0207 0.0351
Schistosoma mansoni tyrosine kinase 0.0906 0.0963 0.2504
Schistosoma mansoni nephrin 0.0279 0.0098 0.0254
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0554 0.0477 0.0583
Echinococcus multilocularis activin receptor type 0.3635 0.4733 0.4733
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.1226 0.1406 0.2379
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.092 0.0982 0.1678
Echinococcus granulosus epidermal growth factor receptor 0.0771 0.0777 0.1314
Schistosoma mansoni serine/threonine protein kinase 0.2225 0.2786 0.7243
Echinococcus multilocularis tyrosine kinase 0.0389 0.0249 0.0249
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.4446 0.5853 1
Schistosoma mansoni serine/threonine kinase 0.0475 0.0368 0.0956
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0462 0.0351 0.3041
Schistosoma mansoni kinase 0.0343 0.0186 0.0483
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0349 0.0195 0.0333
Schistosoma mansoni protein kinase 0.0296 0.0122 0.0316
Echinococcus granulosus tyrosine protein kinase HCK 0.0558 0.0483 0.0817
Brugia malayi SH2 domain containing protein 0.0684 0.0656 0.0802
Echinococcus granulosus tyrosine kinase 0.0389 0.0249 0.0422
Entamoeba histolytica protein kinase, putative 0.0296 0.0122 0.1053
Loa Loa (eye worm) hypothetical protein 0.0684 0.0657 0.0803
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.1451 0.1716 0.2097
Entamoeba histolytica hypothetical protein 0.0369 0.0222 0.1926
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1884 0.2314 0.2828
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.092 0.0982 0.1678
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0317 0.0151 0.0255
Loa Loa (eye worm) hypothetical protein 0.0687 0.0662 0.0809
Schistosoma mansoni serine/threonine protein kinase 0.1026 0.1129 0.2934
Brugia malayi casein kinase I 0.0554 0.0477 0.0583
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0309 0.0139 0.0238
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0269 0.0084 0.0103
Echinococcus granulosus cyclin dependent kinase 19 0.1451 0.1716 0.2903
Echinococcus multilocularis cyclin dependent kinase 5 0.0396 0.0259 0.0259
Echinococcus granulosus serine:threonine protein kinase 0.026 0.0072 0.0121
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.092 0.0982 0.1678
Leishmania major protein kinase, putative 0.0529 0.0443 0.0757
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0319 0.0153 0.0259
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0304
Echinococcus multilocularis dual specificity 0.0244 0.0049 0.0049
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0738 0.0732 0.0732
Echinococcus granulosus slit 2 protein 0.0246 0.0053 0.0089
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0055 0.0067
Echinococcus granulosus N chimaerin 0.0319 0.0153 0.0259
Schistosoma mansoni serine/threonine protein kinase 0.1226 0.1406 0.3656
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0309 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0657 0.062 0.0758
Brugia malayi Variant SH3 domain containing protein 0.0319 0.0153 0.0187
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0475 0.0368 0.0368
Brugia malayi casein kinase 1, delta 0.0554 0.0477 0.0583
Schistosoma mansoni serine/threonine protein kinase 0.0529 0.0443 0.1151
Leishmania major casein kinase, putative 0.0554 0.0477 0.0815
Echinococcus granulosus casein kinase I alpha 0.0554 0.0477 0.0807
Schistosoma mansoni serine/threonine protein kinase 0.0653 0.0614 0.1597
Echinococcus multilocularis 0.0796 0.0812 0.0812
Entamoeba histolytica protein kinase domain containing protein 0.1044 0.1154 1
Entamoeba histolytica protein kinase, putative 0.0633 0.0587 0.5082
Schistosoma mansoni protein kinase 0.2008 0.2485 0.6462
Loa Loa (eye worm) hypothetical protein 0.0462 0.0351 0.0429
Brugia malayi Variant SH3 domain containing protein 0.022 0.0016 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0241 0.0045 0.0368
Loa Loa (eye worm) TK/FAK protein kinase 0.3026 0.3892 0.4757
Giardia lamblia Kinase, NEK 0.0241 0.0045 0.0368
Entamoeba histolytica protein kinase domain containing protein 0.1044 0.1154 1
Loa Loa (eye worm) hypothetical protein 0.0255 0.0064 0.0078
Entamoeba histolytica protein kinase, putative 0.0211 0.0004 0.0032
Echinococcus multilocularis tyrosine protein kinase shark 0.0596 0.0536 0.0536
Giardia lamblia Kinase, PLK 0.028 0.0098 0.0798
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0319 0.0153 0.0398
Loa Loa (eye worm) TK/FER protein kinase 0.0684 0.0656 0.0802
Echinococcus granulosus protein kinase C gamma type 0.0514 0.0423 0.0715
Schistosoma mansoni serine/threonine protein kinase 0.039 0.0251 0.0651
Echinococcus multilocularis N chimaerin 0.0319 0.0153 0.0153
Loa Loa (eye worm) thyroid receptor interactor 0.0643 0.06 0.0733
Echinococcus granulosus cyclin dependent kinase 9 0.0319 0.0153 0.026
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.4487 0.591 1
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0304
Echinococcus multilocularis Immunoglobulin 0.055 0.0472 0.0472
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0738 0.0732 0.1238
Trichomonas vaginalis AGC family protein kinase 0.0475 0.0368 0.2983
Echinococcus multilocularis rac serine:threonine kinase 0.0299 0.0126 0.0126
Echinococcus multilocularis protein kinase c iota type 0.0694 0.0671 0.0671
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0304
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0221 0.0017 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0309 0.0139 0.0362
Brugia malayi Protein kinase domain containing protein 0.0692 0.0668 0.0817
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0376 0.0231 0.0231
Schistosoma mansoni serine/threonine protein kinase 0.027 0.0086 0.0223
Echinococcus multilocularis 0.0209 0.0001 0.0001
Echinococcus multilocularis cyclin dependent kinase 0.0396 0.0259 0.0259
Echinococcus granulosus beta-adrenergic receptor kinase 0.0269 0.0084 0.0142
Schistosoma mansoni tyrosine kinase 0.1204 0.1375 0.3576
Schistosoma mansoni tyrosine kinase 0.0718 0.0703 0.1828
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0462 0.0351 0.3041
Loa Loa (eye worm) TK protein kinase 0.0558 0.0483 0.059
Loa Loa (eye worm) hypothetical protein 0.1531 0.1827 0.2233
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0878 0.0925 0.0925
Echinococcus granulosus Protein kinase C brain isozyme 0.0653 0.0614 0.104
Brugia malayi cyclin-dependent kinase 9 0.0319 0.0153 0.0188
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0475 0.0368 0.0622
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.2225 0.2786 0.3405
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0244 0.0049 0.006
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0349 0.0195 0.033
Trichomonas vaginalis CAMK family protein kinase 0.035 0.0196 0.1589
Entamoeba histolytica protein kinase, putative 0.0244 0.0049 0.0427
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0055 0.0067
Brugia malayi Protein kinase domain containing protein 0.1531 0.1827 0.2233
Schistosoma mansoni serine/threonine protein kinase 0.034 0.0181 0.0471
Echinococcus granulosus dual specificity 0.1026 0.1129 0.191
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0248 0.0055 0.0055
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0647 0.0606 0.0741
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0413 0.0282 0.0482
Echinococcus granulosus cGMP dependent protein kinase 1 0.024 0.0043 0.0073
Loa Loa (eye worm) hypothetical protein 0.0553 0.0476 0.0582
Echinococcus multilocularis serine threonine protein kinase 0.0514 0.0423 0.0423
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0443 0.3591
Echinococcus multilocularis roundabout 2 0.0279 0.0098 0.0098
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1235 0.1418 0.24
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.2225 0.2786 0.2786
Loa Loa (eye worm) hypothetical protein 0.0219 0.0014 0.0017
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1859 0.228 0.228
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.055 0.0472 0.1228
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Echinococcus multilocularis ephrin type A receptor 4 A 0.0271 0.0086 0.0086
Plasmodium falciparum calcium-dependent protein kinase 2 0.0462 0.0351 0.3041
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.035 0.0196 0.024
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.2008 0.2485 0.2485
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0443 0.3591
Entamoeba histolytica cell division protein kinase 2, putative 0.0396 0.0259 0.2242
Echinococcus multilocularis cyclin dependent kinase 1 0.0396 0.0259 0.0259
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0414 0.0284 0.0347
Loa Loa (eye worm) hypothetical protein 0.055 0.0472 0.0577
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1026 0.1129 0.1928
Schistosoma mansoni serine/threonine protein kinase 0.0316 0.0149 0.0387
Echinococcus granulosus tyrosine kinase 0.0738 0.0732 0.1238
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0462 0.0351 0.3041
Echinococcus multilocularis tyrosine protein kinase Blk 0.0738 0.0732 0.0732
Echinococcus granulosus cGMP dependent protein kinase 1 0.024 0.0043 0.0073
Brugia malayi RhoGAP domain containing protein 0.0319 0.0153 0.0187
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.1101 0.1233 0.2107
Onchocerca volvulus Serine\/threonine kinase homolog 0.0268 0.0083 0.0101
Trichomonas vaginalis CK1 family protein kinase 0.0554 0.0477 0.3868
Schistosoma mansoni serine/threonine protein kinase 0.0308 0.0138 0.0359
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Plasmodium vivax serine/threonine kinase-1, putative 0.092 0.0982 0.851
Plasmodium vivax glycogen synthase kinase 3, putative 0.1044 0.1154 1
Loa Loa (eye worm) hypothetical protein 0.055 0.0472 0.0577
Echinococcus granulosus serine:threonine protein kinase 0.026 0.0072 0.0121
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.0084 0.0219
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0595 0.0534 0.0652
Schistosoma mansoni serine/threonine protein kinase 0.0503 0.0408 0.106
Schistosoma mansoni serine/threonine protein kinase 0.0475 0.0368 0.0956
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0554 0.0477 0.0815
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0893 0.0945 0.1155
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.4446 0.5853 0.7154
Schistosoma mansoni serine/threonine protein kinase 0.1424 0.168 0.4367
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2041 0.2531 0.2531
Entamoeba histolytica PH domain containing protein kinase, putative 0.0299 0.0126 0.1089
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.1545 0.1847 0.2257
Onchocerca volvulus 0.034 0.0181 0.0222
Trichomonas vaginalis CAMK family protein kinase 0.028 0.0098 0.0798
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0587 0.0523 0.0893
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0554 0.0477 0.0583
Echinococcus multilocularis raf serine:threonine protein kinase 0.0347 0.0192 0.0192
Schistosoma mansoni tyrosine kinase 0.0364 0.0215 0.0558
Giardia lamblia Kinase, STE STE20 0.0317 0.0151 0.1222
Echinococcus granulosus tyrosine protein kinase Fyn 0.0878 0.0925 0.1565
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0223 0.002 0.002
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.1101 0.1233 0.2107
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0615 0.0561 0.0686
Echinococcus multilocularis mitogen activated protein kinase 11 0.4446 0.5853 0.5853
Schistosoma mansoni protein kinase 0.0317 0.0151 0.0392
Onchocerca volvulus 0.0281 0.01 0.0122
Echinococcus granulosus c src tyrosine kinase 0.0528 0.0442 0.0748
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0309 0.0139 0.0238
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1296 0.1502 0.1836
Entamoeba histolytica protein kinase domain containing protein 0.0529 0.0443 0.3837
Toxoplasma gondii casein kinase I 0.0554 0.0477 0.4133
Echinococcus granulosus TGF beta receptor type 1 0.0784 0.0795 0.1346
Schistosoma mansoni adapter molecule crk 0.032 0.0154 0.0401
Trichomonas vaginalis AGC family protein kinase 0.0513 0.0421 0.3411
Schistosoma mansoni serine/threonine protein kinase 0.0522 0.0433 0.1126
Echinococcus granulosus protein kinase shaggy 0.1044 0.1154 0.1953
Schistosoma mansoni serine/threonine protein kinase 0.1884 0.2314 0.6016
Schistosoma mansoni serine/threonine protein kinase 0.0396 0.0259 0.0673
Loa Loa (eye worm) sex muscle abnormal protein 5 0.032 0.0154 0.0188
Loa Loa (eye worm) hypothetical protein 0.0864 0.0906 0.1108
Loa Loa (eye worm) hypothetical protein 0.0497 0.0399 0.0487
Loa Loa (eye worm) AGC/AKT protein kinase 0.0633 0.0587 0.0717
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0529 0.0443 0.3837
Echinococcus granulosus mitogen activated protein kinase 14 0.4446 0.5853 0.9903
Entamoeba histolytica serine/threonine protein kinase, putative 0.028 0.0098 0.0852
Schistosoma mansoni serine/threonine protein kinase 0.028 0.0098 0.0256
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.028 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.1322 0.1539 0.1881
Brugia malayi Protein kinase domain containing protein 0.069 0.0665 0.0813
Schistosoma mansoni serine/threonine protein kinase 0.0475 0.0368 0.0956
Echinococcus granulosus calcium dependent protein kinase 0.0321 0.0156 0.0264
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.1545 0.1847 0.2257
Trichomonas vaginalis STE family protein kinase 0.0317 0.0151 0.1222
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0878 0.0925 0.1565
Brugia malayi Peroxidasin 0.0251 0.0058 0.0071
Brugia malayi Protein kinase domain containing protein 0.3994 0.5228 0.6391
Trypanosoma brucei protein kinase, putative 0.1044 0.1154 0.1972
Brugia malayi Sex muscle abnormal protein 5 0.032 0.0154 0.0188
Schistosoma mansoni vesicular amine transporter 0.055 0.0472 0.1228
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0261 0.0073 0.0125
Brugia malayi Protein kinase domain containing protein 0.1944 0.2397 0.2929
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0462 0.0351 0.0594
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0657 0.062 0.106
Echinococcus granulosus lachesin 0.0248 0.0055 0.0093
Echinococcus granulosus serine:threonine protein kinase N2 0.1376 0.1613 0.2729
Giardia lamblia Kinase, AGC AKT 0.0893 0.0945 0.7665
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0304
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0462 0.0351 0.0429
Schistosoma mansoni hypothetical protein 0.0587 0.0523 0.1359
Schistosoma mansoni roundabout 0.0248 0.0055 0.0142
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0728 0.0717 0.1214
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0657 0.062 0.062
Onchocerca volvulus 0.0864 0.0906 0.1108
Echinococcus multilocularis casein kinase I gamma 0.0316 0.0149 0.0149
Trypanosoma brucei cdc2-related kinase 3 0.0396 0.0259 0.0442
Entamoeba histolytica protein kinase, putative 0.0633 0.0587 0.5082
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0462 0.0351 0.0351
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0692 0.0668 0.0817
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0529 0.0443 0.3837
Onchocerca volvulus 0.0244 0.0049 0.006
Echinococcus multilocularis casein kinase I delta 0.0554 0.0477 0.0477
Brugia malayi Protein kinase domain containing protein 0.0389 0.0249 0.0304
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.092 0.0982 0.1678
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0055 0.0067
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1044 0.1154 0.1154
Onchocerca volvulus 0.0687 0.0662 0.0809
Onchocerca volvulus 0.0389 0.0249 0.0304
Trypanosoma cruzi cdc2-related kinase 1 0.0396 0.0259 0.0442
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.034 0.0182 0.158
Entamoeba histolytica hypothetical protein 0.0211 0.0004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0475 0.0369 0.045
Schistosoma mansoni protein kinase 0.0349 0.0195 0.0506
Echinococcus multilocularis growth factor receptor bound protein 2 0.032 0.0154 0.0154
Entamoeba histolytica hypothetical protein 0.0211 0.0004 0.0032
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0349 0.0195 0.1687
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0462 0.0351 0.0429
Schistosoma mansoni protein kinase 0.0784 0.0795 0.2068
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0657 0.062 0.106
Echinococcus granulosus NDR protein kinase 0.0475 0.0368 0.0622
Trichomonas vaginalis CMGC family protein kinase 0.0396 0.0259 0.2098
Loa Loa (eye worm) TK protein kinase 0.0738 0.0732 0.0895
Loa Loa (eye worm) protein kinase domain-containing protein 0.0316 0.0149 0.0182
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0657 0.062 0.062
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0304
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0244 0.0049 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0462 0.0351 0.0912
Schistosoma mansoni tyrosine kinase 0.2993 0.3846 1
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.2052 0.2547 0.3113
Schistosoma mansoni serine/threonine protein kinase 0.1376 0.1613 0.4193
Plasmodium falciparum casein kinase 1 0.0554 0.0477 0.4133
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0443 0.3591
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0771 0.0777 0.1314
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0657 0.062 0.062
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0319 0.0153 0.0153
Echinococcus multilocularis calcium activated potassium channel 0.027 0.0086 0.0086
Trichomonas vaginalis CK1 family protein kinase 0.0554 0.0477 0.3868
Echinococcus multilocularis neuroglian 0.0718 0.0703 0.0703
Echinococcus multilocularis fibroblast growth factor receptor 4 0.1289 0.1493 0.1493
Entamoeba histolytica protein kinase domain containing protein 0.0349 0.0195 0.1687
Plasmodium falciparum protein serine/threonine kinase-1 0.092 0.0982 0.851
Echinococcus multilocularis roundabout 2 0.0279 0.0098 0.0098
Trichomonas vaginalis AGC family protein kinase 0.0506 0.0411 0.3333
Schistosoma mansoni kinase 0.0319 0.0153 0.0399
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0684 0.0656 0.0656
Entamoeba histolytica protein kinase, putative 0.1026 0.1129 0.9778
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0878 0.0925 0.1565
Schistosoma mansoni titin 0.034 0.0181 0.0471
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0684 0.0656 0.1111
Echinococcus multilocularis casein kinase I delta 0.0554 0.0477 0.0477
Schistosoma mansoni serine/threonine protein kinase 0.0886 0.0936 0.2435
Loa Loa (eye worm) TK/KIN16 protein kinase 0.3073 0.3957 0.4837
Schistosoma mansoni cell adhesion molecule 0.0662 0.0626 0.1629
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0055 0.0067
Schistosoma mansoni nck2/grb4 0.032 0.0154 0.0401
Onchocerca volvulus 0.0286 0.0107 0.0131
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0396 0.0259 0.0316
Schistosoma mansoni tyrosine kinase 0.0771 0.0777 0.2019
Echinococcus granulosus mitogen activated protein kinase 11 0.4446 0.5853 0.9903
Echinococcus granulosus serine threonine protein kinase nrc 0.0261 0.0073 0.0123
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1859 0.228 0.3858
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0462 0.0351 0.3041
Echinococcus granulosus cyclin dependent kinase 9 0.0351 0.0197 0.0333
Trichomonas vaginalis CAMK family protein kinase 0.0221 0.0017 0.0139
Loa Loa (eye worm) AGC/NDR protein kinase 0.0475 0.0368 0.045
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0462 0.0351 0.0351
Brugia malayi Fes/CIP4 homology domain containing protein 0.0643 0.06 0.0733
Schistosoma mansoni serine/threonine protein kinase 0.0492 0.0392 0.1019
Echinococcus granulosus protein kinase c epsilon type 0.0615 0.0561 0.095
Plasmodium falciparum glycogen synthase kinase 3 0.1044 0.1154 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0335 0.0174 0.0295
Entamoeba histolytica protein kinase, putative 0.0595 0.0534 0.4625
Brugia malayi Variant SH3 domain containing protein 0.032 0.0154 0.0188
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0309 0.0139 0.0238
Echinococcus multilocularis c Jun NH2 terminal kinase 0.2439 0.308 0.308
Giardia lamblia Kinase, CMGC CDK 0.0396 0.0259 0.2098
Plasmodium falciparum protein kinase 5 0.0396 0.0259 0.2242
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0462 0.0351 0.0429
Schistosoma mansoni serine/threonine protein kinase 0.0657 0.062 0.1613
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0657 0.062 0.106
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.039 0.0251 0.0251
Trypanosoma cruzi casein kinase, putative 0.0554 0.0477 0.0815
Loa Loa (eye worm) AGC/PKA protein kinase 0.0657 0.062 0.0758
Entamoeba histolytica protein kinase, putative 0.0558 0.0483 0.4183
Brugia malayi Protein kinase domain containing protein 0.0268 0.0083 0.0101
Brugia malayi protein C17H12.11 0.0549 0.047 0.0575
Loa Loa (eye worm) hypothetical protein 0.0587 0.0523 0.0639
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0718 0.0703 0.119
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0049 0.0399
Echinococcus granulosus tyrosine protein kinase ABL1 0.2041 0.2531 0.4283
Brugia malayi Protein kinase domain containing protein 0.0316 0.0149 0.0182
Brugia malayi protein-tyrosine kinase 0.0738 0.0732 0.0895
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.024 0.0043 0.0376
Onchocerca volvulus 0.0826 0.0853 0.1043
Echinococcus granulosus serine:threonine kinase SAD 1 0.0309 0.0139 0.0235
Plasmodium falciparum calcium-dependent protein kinase 3 0.0462 0.0351 0.3041
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0349 0.0195 0.0195
Brugia malayi Protein kinase domain containing protein 0.0389 0.0249 0.0304
Brugia malayi Immunoglobulin I-set domain containing protein 0.0279 0.0098 0.0119
Entamoeba histolytica tyrosin kinase, putative 0.0248 0.0054 0.0472
Echinococcus granulosus serine:threonine protein kinase mig 15 0.1242 0.1428 0.2416
Echinococcus multilocularis roundabout 2 0.0829 0.0858 0.0858
Echinococcus multilocularis NCK adaptor protein 0.0335 0.0174 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.0914 0.0974 0.2533
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0309 0.0139 0.0238
Loa Loa (eye worm) hypothetical protein 0.0581 0.0515 0.063
Schistosoma mansoni serine/threonine protein kinase 0.0319 0.0153 0.0399
Brugia malayi STE20-like kinase MST 0.0359 0.0207 0.0254
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0309 0.0139 0.017
Loa Loa (eye worm) TK/INSR protein kinase 0.1204 0.1375 0.1681
Echinococcus multilocularis basement membrane specific heparan sulfate 0.055 0.0472 0.0472
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0529 0.0443 0.0443
Echinococcus multilocularis hemicentin 1 0.0248 0.0055 0.0055
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0886 0.0936 0.1584
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0475 0.0368 0.0368
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Echinococcus granulosus serine:threonine protein kinase TAO1 0.2225 0.2786 0.4714
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.092 0.0982 0.1678
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0396 0.0259 0.0316
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0321 0.0156 0.1352
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1296 0.1502 0.2542
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0268 0.0083 0.014
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0462 0.0351 0.0594
Loa Loa (eye worm) hypothetical protein 0.0779 0.0788 0.0963
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0376 0.0231 0.0391
Brugia malayi SRC-1 0.0878 0.0925 0.113
Echinococcus granulosus dual specificity 0.0244 0.0049 0.0083
Echinococcus multilocularis dual specificity 0.0244 0.0049 0.0049
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0376 0.0232 0.0232
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0587 0.4757
Trypanosoma cruzi cdc2-related kinase 1 0.0396 0.0259 0.0442
Entamoeba histolytica protein kinase 2, putative 0.0261 0.0073 0.0632
Schistosoma mansoni tyrosine kinase 0.0528 0.0442 0.1149
Echinococcus granulosus casein kinase I delta 0.0554 0.0477 0.0807
Echinococcus granulosus neuroglian 0.0718 0.0703 0.119
Loa Loa (eye worm) IKK protein kinase 0.6132 0.8181 1
Echinococcus multilocularis aurora kinase A 0.0529 0.0443 0.0443
Echinococcus multilocularis expressed conserved protein 0.024 0.0043 0.0043
Trypanosoma cruzi cdc2-related kinase 3 0.0396 0.0259 0.0442
Trypanosoma cruzi casein kinase, putative 0.0554 0.0477 0.0815
Loa Loa (eye worm) TK/ROR protein kinase 0.0376 0.0231 0.0283
Entamoeba histolytica hypothetical protein 0.1026 0.1129 0.9778
Echinococcus multilocularis serine:threonine protein kinase N2 0.0475 0.0368 0.0368
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0878 0.0925 0.0925
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1044 0.1154 0.3001
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0279 0.0098 0.0119
Toxoplasma gondii aurora kinase 0.0529 0.0443 0.3837
Onchocerca volvulus 0.0389 0.0249 0.0304
Trichomonas vaginalis CAMK family protein kinase 0.028 0.0098 0.0798
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0657 0.062 0.5374
Schistosoma mansoni vav2 0.0357 0.0206 0.0535
Echinococcus granulosus activin receptor type 0.3635 0.4733 0.8008
Trichomonas vaginalis CAMK family protein kinase 0.0462 0.0351 0.2846
Loa Loa (eye worm) hypothetical protein 0.1159 0.1312 0.1604
Schistosoma mansoni serine/threonine kinase 0.0382 0.0239 0.0622
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0306 0.0135 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.0049 0.0128
Schistosoma mansoni serine/threonine protein kinase 0.0657 0.062 0.1613
Brugia malayi serine/threonine-protein kinase 6 0.0529 0.0443 0.0541
Brugia malayi Protein kinase domain containing protein 0.0296 0.0122 0.0149
Loa Loa (eye worm) hypothetical protein 0.0255 0.0064 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.0306 0.0135 0.035
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0728 0.0717 0.0717
Loa Loa (eye worm) hypothetical protein 0.026 0.0072 0.0088
Loa Loa (eye worm) hypothetical protein 0.353 0.4587 0.5607
Trichomonas vaginalis STE family protein kinase 0.0296 0.0122 0.0986
Brugia malayi Protein kinase domain 0.0317 0.0151 0.0184
Echinococcus granulosus tyrosine protein kinase Lyn 0.1019 0.112 0.1894
Echinococcus multilocularis serine:threonine protein kinase N2 0.0901 0.0957 0.0957
Schistosoma mansoni serine/threonine protein kinase 0.0554 0.0477 0.124
Loa Loa (eye worm) hypothetical protein 0.0248 0.0055 0.0067
Echinococcus granulosus tyrosine protein kinase Blk 0.0738 0.0732 0.1238
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.1289 0.1493 0.2527
Loa Loa (eye worm) TK/EPH protein kinase 0.0288 0.0109 0.0134
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.1289 0.1493 0.1493
Loa Loa (eye worm) hypothetical protein 0.0251 0.0058 0.0071
Echinococcus granulosus aurora kinase A 0.0529 0.0443 0.0749
Loa Loa (eye worm) hypothetical protein 0.0826 0.0853 0.1043
Entamoeba histolytica p21-activated kinase 0.0356 0.0203 0.1763
Echinococcus granulosus raf serine:threonine protein kinase 0.0347 0.0192 0.0324
Entamoeba histolytica protein kinase, putative 0.0317 0.0151 0.1305
Trichomonas vaginalis TKL family protein kinase 0.021 0.0003 0.0021
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0462 0.0351 0.3041
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0657 0.062 0.105
Echinococcus granulosus peroxidasin 0.0251 0.0058 0.0099
Schistosoma mansoni tyrosine kinase 0.0771 0.0777 0.2019
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.4446 0.5853 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0878 0.0925 0.1565
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Echinococcus granulosus dual specificity mitogen activated protein 0.1101 0.1233 0.2087
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1884 0.2314 0.2314
Echinococcus multilocularis protein kinase c epsilon type 0.0615 0.0561 0.0561
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1044 0.1154 0.1972
Brugia malayi hypothetical protein 0.0389 0.0249 0.0304
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.1226 0.1406 0.1719
Echinococcus multilocularis protein KINase family member (kin 25) 0.0718 0.0703 0.0703
Schistosoma mansoni serine/threonine protein kinase 0.0304 0.0132 0.0344
Echinococcus granulosus cyclin dependent kinase 5 0.0396 0.0259 0.0438
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.092 0.0982 0.1678
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0657 0.062 0.106
Entamoeba histolytica protein kinase, putative 0.1026 0.1129 0.9778
Loa Loa (eye worm) CAMK protein kinase 0.034 0.0181 0.0222
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0967 0.1048 0.1281
Giardia lamblia Kinase, CMGC CDK 0.0396 0.0259 0.2098
Loa Loa (eye worm) hypothetical protein 0.0692 0.0668 0.0817
Leishmania major protein kinase A catalytic subunit 0.0657 0.062 0.106
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0261 0.0073 0.0073
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0492 0.0392 0.0392
Echinococcus multilocularis cyclin dependent kinase 9 0.0319 0.0153 0.0153
Entamoeba histolytica cell division protein kinase 2, putative 0.0427 0.0302 0.2616
Schistosoma mansoni growth factor receptor-bound protein 0.032 0.0154 0.0401
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0261 0.0073 0.0123
Schistosoma mansoni protein kinase 0.2008 0.2485 0.6462
Echinococcus multilocularis casein kinase I alpha 0.0554 0.0477 0.0477
Brugia malayi protein kinase C II. 0.0615 0.0561 0.0686
Trypanosoma brucei protein kinase, putative 0.0349 0.0195 0.0333
Schistosoma mansoni cell adhesion molecule 0.0248 0.0055 0.0142
Schistosoma mansoni neuroglian 0.0279 0.0098 0.0254
Echinococcus granulosus titin 0.034 0.0181 0.0307
Echinococcus granulosus twitchin 0.0859 0.0898 0.152
Schistosoma mansoni vam6/vps39 related 0.0587 0.0523 0.1359
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0043 0.0113
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0396 0.0259 0.0438
Giardia lamblia Kinase, CMGC DYRK 0.0244 0.0049 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0139 0.1128
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0878 0.0925 0.0925
Loa Loa (eye worm) hypothetical protein 0.0798 0.0815 0.0996
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0587 0.4757
Echinococcus granulosus cyclin dependent kinase 0.0396 0.0259 0.0438
Brugia malayi SH2 domain containing protein 0.0389 0.0249 0.0304
Onchocerca volvulus 0.0684 0.0657 0.0803
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0589 0.0526 0.0526
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.4446 0.5853 1
Leishmania major protein kinase A catalytic subunit isoform 2 0.0657 0.062 0.106
Loa Loa (eye worm) hypothetical protein 0.032 0.0154 0.0188
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1044 0.1154 0.1953

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 45 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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