Detailed information for compound 1063231

Basic information

Technical information
  • TDR Targets ID: 1063231
  • Name: ZINC03900211
  • MW: 364.438 | Formula: C22H24N2O3
  • H donors: 1 H acceptors: 3 LogP: 2.91 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(c2ccc(cc2)C(=O)NC2CCCCC2)C(=O)[C@@H]2[C@H]1[C@@H]1C=C[C@H]2C1
  • InChi: 1S/C22H24N2O3/c25-20(23-16-4-2-1-3-5-16)13-8-10-17(11-9-13)24-21(26)18-14-6-7-15(12-14)19(18)22(24)27/h6-11,14-16,18-19H,1-5,12H2,(H,23,25)/t14-,15+,18-,19+
  • InChiKey: INLGNWCUKFGRTH-FDCRZUCXSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase 0.0109 0.0126 0.1402
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0002 0.0002
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0749 0.1146 0.1145
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0076 0.3292
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0333 0.0483 0.0483
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0167 0.0218 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0333 0.0483 0.0481
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.001 0.0008
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.006 0.0047 0.0898
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.006 0.0047 0.0266
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0115 0.0135 0.0172
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0184 0.0245 0.2687
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0126 0.102
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0049 0.003 0.0277
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0585 0.0885 0.0885
Mycobacterium leprae putative cytochrome p450 0.006 0.0047 0.0898
Schistosoma mansoni caspase-7 (C14 family) 0.0105 0.012 0.0152
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0355 0.0518 0.5804
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0041 0.0018 0.0092
Mycobacterium ulcerans hypothetical protein 0.0109 0.0126 0.5075
Echinococcus granulosus GPCR family 2 0.0033 0.0005 0.0005
Trichomonas vaginalis antibiotic synthetase, putative 0.0049 0.003 0.0238
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0119 0.0956
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.006 0.0047 0.0266
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.006 0.0047 0.0898
Leishmania major cathepsin L-like protease 0.0064 0.0055 0.0124
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0172 0.0227 0.029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0126 0.016
Brugia malayi AMP-binding enzyme family protein 0.0167 0.0218 0.2448
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.003 0.0104
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0033 0.0133
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0126 0.102
Onchocerca volvulus 0.0109 0.0126 0.3605
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0055 0.0515
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0184 0.0245 0.0313
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.001 0.001
Brugia malayi RNA binding protein 0.0194 0.0261 0.2932
Toxoplasma gondii target of rapamycin (TOR), putative 0.0562 0.0848 1
Onchocerca volvulus 0.0115 0.0135 0.3879
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0187 0.025 0.2742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0855 0.9662
Leishmania major 4-coumarate:coa ligase-like protein 0.0167 0.0218 0.0576
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0115 0.0135 0.0365
Schistosoma mansoni hypothetical protein 0.0049 0.0031 0.0038
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0556 0.0838 0.946
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.0674 0.0672
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0585 0.0885 1
Entamoeba histolytica hypothetical protein 0.0333 0.0483 0.5407
Plasmodium vivax glutathione reductase, putative 0.0046 0.0025 0.1046
Schistosoma mansoni hypothetical protein 0.0083 0.0084 0.0106
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0105 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0618
Mycobacterium ulcerans acyl-CoA synthetase 0.0167 0.0218 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0025 0.0025
Mycobacterium tuberculosis Conserved hypothetical protein 0.0115 0.0135 0.1111
Entamoeba histolytica hypothetical protein 0.0115 0.0135 0.1434
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.006 0.0047 0.0898
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0041 0.0018 0.0092
Leishmania major cathepsin L-like protease 0.0064 0.0055 0.0124
Trichomonas vaginalis esterase, putative 0.0109 0.0126 0.1326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.0165 0.177
Trypanosoma brucei trypanothione reductase 0.0046 0.0025 0.0181
Trypanosoma cruzi cytochrome p450-like protein, putative 0.006 0.0047 0.011
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0041 0.0018 0.0023
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0203 0.0275 0.0353
Schistosoma mansoni acetyl-CoA synthetase 0.0049 0.003 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0167 0.0218 0.0576
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0126 0.1402
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0015 0.0068
Brugia malayi Cytochrome P450 family protein 0.0089 0.0094 0.1046
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0041 0.0018 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0537 0.0808 0.9123
Echinococcus multilocularis protein patched 0.0086 0.0089 0.0087
Loa Loa (eye worm) hypothetical protein 0.0125 0.0151 0.1447
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.002 0.0176
Trypanosoma cruzi cytochrome P450, putative 0.0089 0.0094 0.0246
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.006 0.0047 0.0266
Echinococcus multilocularis caspase 3 0.0077 0.0075 0.0073
Entamoeba histolytica protein kinase rad3, putative 0.0304 0.0436 0.4871
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1645 0.2574 0.2572
Schistosoma mansoni hypothetical protein 0.0071 0.0065 0.0082
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0041 0.0018 0.0022
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0115 0.0135 0.5923
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.002 0.002
Onchocerca volvulus 0.015 0.0191 0.5511
Onchocerca volvulus 0.0049 0.003 0.083
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0172 0.0227 0.06
Schistosoma mansoni hypothetical protein 0.0222 0.0305 0.0391
Loa Loa (eye worm) hypothetical protein 0.0109 0.0126 0.1202
Echinococcus granulosus cytochrome P450 2K1 0.006 0.0047 0.0047
Echinococcus multilocularis Zinc finger, PHD finger 0.0172 0.0227 0.0225
Loa Loa (eye worm) hypothetical protein 0.0041 0.0018 0.0153
Brugia malayi hypothetical protein 0.0243 0.0339 0.3815
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0098 0.0108 0.1122
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0115 0.0135 0.0135
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0556 0.0838 0.2408
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0033 0.0067
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0304 0.0436 0.4915
Echinococcus multilocularis tar DNA binding protein 0.0194 0.0261 0.0259
Onchocerca volvulus 0.0049 0.003 0.083
Leishmania major hypothetical protein, conserved 0.2309 0.3632 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0076 0.2426
Loa Loa (eye worm) cytochrome P450 family protein 0.0089 0.0094 0.0897
Mycobacterium leprae Conserved hypothetical protein 0.006 0.0047 0.0898
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0585 0.0885 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0244 0.0341 0.3789
Echinococcus granulosus serine protein kinase ATM 0.032 0.0462 0.0462
Plasmodium vivax acyl-CoA synthetase, putative 0.0125 0.0151 0.6627
Loa Loa (eye worm) hypothetical protein 0.0109 0.0126 0.1202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0055 0.0515
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.006 0.0047 0.0898
Loa Loa (eye worm) hypothetical protein 0.0037 0.0011 0.0089
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0004
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0041 0.0018 0.0092
Plasmodium falciparum acyl-CoA synthetase 0.0125 0.0151 0.6374
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0126 0.1326
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0167 0.0218 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0115 0.0135 0.1575
Leishmania major cytochrome p450-like protein 0.006 0.0047 0.0104
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0076 0.2426
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.003 0.0104
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.0277
Trichomonas vaginalis antibiotic synthetase, putative 0.0049 0.003 0.0238
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.032 0.0462 0.0594
Brugia malayi TAR-binding protein 0.0194 0.0261 0.2932
Trichomonas vaginalis conserved hypothetical protein 0.0189 0.0253 0.2783
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0585 0.0885 0.2545
Onchocerca volvulus 0.0167 0.0218 0.6297
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0125 0.0151 0.1263
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0025 0.0046
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.0277
Loa Loa (eye worm) phosphatidylinositol 3 0.0115 0.0135 0.1293
Trypanosoma cruzi cytochrome P450, putative 0.0089 0.0094 0.0246
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0205 0.0279 0.2695
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0582 0.0879 0.2528
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0005 0.0028
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0585 0.0885 0.1139
Leishmania major acetyl-CoA synthetase, putative 0.0049 0.003 0.0057
Brugia malayi beta-lactamase family protein 0.0109 0.0126 0.1402
Schistosoma mansoni hypothetical protein 0.0083 0.0084 0.0106
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.006 0.0047 0.0266
Leishmania major trypanothione reductase 0.0046 0.0025 0.0044
Loa Loa (eye worm) hypothetical protein 0.0033 0.0005 0.0028
Onchocerca volvulus 0.0109 0.0126 0.3605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0135 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.0462 0.517
Echinococcus granulosus sentrin specific protease 1 0.0041 0.0018 0.0018
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.6305 1 1
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0135 0.5923
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0172 0.0227 0.0632
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0152 0.0194 0.2108
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0033 0.0158
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0076 0.4375
Loa Loa (eye worm) hypothetical protein 0.0148 0.0188 0.1806
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0115 0.0135 0.0172
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.006 0.0047 0.0266
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0098 0.0108 0.1122
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.006 0.0047 0.0898
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.006 0.0047 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0525 0.0789 0.8903
Onchocerca volvulus 0.0041 0.0018 0.0458
Loa Loa (eye worm) hypothetical protein 0.0109 0.0126 0.1202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0341 0.0495 0.5545
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0282 0.0402 0.4487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0562 0.0848 0.9577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0055 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0562 0.0848 0.9577
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0582 0.0879 0.2528
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0049 0.003 0.0323
Brugia malayi AMP-binding enzyme family protein 0.0049 0.003 0.0323
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0126 0.0338
Echinococcus multilocularis sentrin specific protease 7 0.0184 0.0245 0.0243
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0118 0.014 0.1159
Loa Loa (eye worm) hypothetical protein 0.0125 0.0151 0.1447
Brugia malayi AMP-binding enzyme family protein 0.0049 0.003 0.0323
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.001 0.0087
Brugia malayi CHE-14 protein 0.0086 0.0089 0.0986
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0585 0.0885 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.006 0.0047 0.0536
Loa Loa (eye worm) hypothetical protein 0.0041 0.0018 0.0153
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0055 0.0131
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0055 0.0131
Loa Loa (eye worm) hypothetical protein 0.0125 0.0151 0.1447
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0695 0.106 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.006 0.0047 0.0898
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0055 0.0131
Mycobacterium tuberculosis Conserved protein 0.0109 0.0126 0.102
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0167 0.0218 0.1909
Onchocerca volvulus 0.0109 0.0126 0.3605
Mycobacterium tuberculosis Probable reductase 0.0105 0.0119 0.0956
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0055 0.0515
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.006 0.0047 0.011
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0115 0.0135 0.0133
Echinococcus multilocularis Niemann Pick C1 protein 0.02 0.0271 0.0269
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0115 0.0135 0.0135
Echinococcus granulosus tumor protein p63 0.101 0.1561 0.1561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0055 0.0515
Loa Loa (eye worm) hypothetical protein 0.0109 0.0126 0.1202
Loa Loa (eye worm) hypothetical protein 0.0109 0.0126 0.1202
Leishmania major acetyl-CoA synthetase, putative 0.0049 0.003 0.0057
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0098 0.0108 0.1199
Onchocerca volvulus 0.0115 0.0135 0.3879
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.006 0.0047 0.0266
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0098 0.0108 0.1122
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0005 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.006 0.0047 0.0266
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0041 0.0018 0.0092
Entamoeba histolytica acyl-CoA synthetase, putative 0.0167 0.0218 0.2382
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0115 0.0135 0.0133
Onchocerca volvulus 0.0049 0.0031 0.0853
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0076 0.0875
Trypanosoma cruzi hypothetical protein 0.0098 0.0108 0.0286
Leishmania major phosphatidylinositol kinase, putative 0.0115 0.0135 0.0347
Loa Loa (eye worm) Ulp1 protease 0.0041 0.0018 0.0153
Brugia malayi beta-lactamase family protein 0.0109 0.0126 0.1402
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0172 0.0227 0.2658
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0041 0.0018 0.0092
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0167 0.0218 1
Echinococcus multilocularis caspase 0.0105 0.012 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0126 0.0338
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0089 0.0089
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.006 0.0047 0.0898
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.002 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0341 0.0495 0.5545
Trichomonas vaginalis set domain proteins, putative 0.0247 0.0345 0.3835
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0749 0.1146 0.1476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.0818 0.924
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0025 0.1046
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0076 0.5
Echinococcus multilocularis Niemann Pick C1 protein 0.0285 0.0407 0.0405
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0004
Schistosoma mansoni cytochrome P450 0.006 0.0047 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0562 0.0848 0.9577
Loa Loa (eye worm) hypothetical protein 0.0125 0.0151 0.1447
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0115 0.0135 0.1434
Mycobacterium leprae Probable lipase LipE 0.0109 0.0126 0.5075
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0105 0.012 0.0118
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0126 0.1326
Loa Loa (eye worm) phosphatidylinositol kinase 0.0115 0.0135 0.1293
Leishmania major phosphatidylinositol 3-kinase, putative 0.0525 0.0789 0.2152
Loa Loa (eye worm) phosphatidylinositol 3 0.0115 0.0135 0.1293
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0026 0.0031
Loa Loa (eye worm) hypothetical protein 0.0336 0.0488 0.4721
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0537 0.0808 0.9123
Leishmania major phosphatidylinositol kinase related protein, putative 0.0131 0.0161 0.0419
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.006 0.0047 0.0898
Entamoeba histolytica hypothetical protein 0.032 0.0462 0.517
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0167 0.0218 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0055 0.0515
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0115 0.0135 0.1434
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0172 0.0227 0.029
Loa Loa (eye worm) hypothetical protein 0.0105 0.012 0.1144
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0222 0.0305 0.0304
Giardia lamblia GTOR 0.0585 0.0885 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0537 0.0808 0.2205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0585 0.0885 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0336 0.0488 0.5747
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0855 0.9662
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.0298 0.2871
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.006 0.0047 0.043
Mycobacterium leprae conserved hypothetical protein 0.0115 0.0135 0.5578
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0261 0.0334
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0004
Brugia malayi hypothetical protein 0.0333 0.0483 0.5447
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.006 0.0047 0.0266
Brugia malayi Cytochrome P450 family protein 0.0089 0.0094 0.1046
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0244 0.0341 0.0438
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.006 0.0047 0.0266
Loa Loa (eye worm) hypothetical protein 0.0243 0.0339 0.3271
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0041 0.0018 0.0092
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0126 0.102
Leishmania major 4-coumarate:coa ligase-like protein 0.0167 0.0218 0.0576
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.006 0.0047 0.0898
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0585 0.0885 0.2545
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0354 0.0517 0.0515
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0567 0.0856 0.9664
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0119 0.0956
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0119 0.0956
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0126 0.1326
Trypanosoma cruzi target of rapamycin kinase 3 0.0567 0.0856 0.246
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0194 0.0261 0.2933
Mycobacterium ulcerans acyl-CoA synthetase 0.0167 0.0218 1
Brugia malayi AMP-binding enzyme family protein 0.0049 0.003 0.0323
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.003 0.0104
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.006 0.0047 0.0266
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0304 0.0436 0.0434
Brugia malayi AMP-binding enzyme family protein 0.0167 0.0218 0.2448
Toxoplasma gondii FATC domain-containing protein 0.032 0.0462 0.544
Schistosoma mansoni hypothetical protein 0.0333 0.0483 0.062
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.0674 0.0674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0585 0.0885 1
Brugia malayi hypothetical protein 0.015 0.0191 0.2143
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0115 0.0135 0.1434
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0172 0.0227 0.2658
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0126 0.1326
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0055 0.0515
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0261 0.0334
Loa Loa (eye worm) phosphatidylinositol 3 0.0129 0.0158 0.1521
Schistosoma mansoni hypothetical protein 0.0083 0.0084 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0261 0.0334
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0115 0.0135 0.1509
Plasmodium vivax hypothetical protein 0.0115 0.0135 0.5923
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0119 0.4718
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0049 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0525 0.0789 0.8903
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0126 0.1202
Schistosoma mansoni microtubule-associated protein tau 0.4898 0.7757 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0049 0.003 0.0061
Echinococcus granulosus neuropeptide s receptor 0.0453 0.0674 0.0674
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0556 0.0838 0.946
Trichomonas vaginalis PIKK family atypical protein kinase 0.0548 0.0826 0.9326
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0049 0.003 0.0323
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0167 0.0218 1
Trypanosoma brucei cytochrome P450, putative 0.0089 0.0094 0.0967
Brugia malayi Niemann-Pick C1 protein precursor 0.02 0.0271 0.3043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.0455 0.509
Mycobacterium ulcerans acyl-CoA synthetase 0.0167 0.0218 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0138 0.1135
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.006 0.0047 0.0898
Loa Loa (eye worm) hypothetical protein 0.015 0.0191 0.1837
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0131 0.0161 0.0441
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.006 0.0047 0.0266
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.0818 0.924
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0115 0.0135 0.5617
Echinococcus granulosus caspase 0.0105 0.012 0.012
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.006 0.0047 0.011
Loa Loa (eye worm) hypothetical protein 0.0167 0.0218 0.2099
Echinococcus granulosus sentrin specific protease 8 0.0098 0.0108 0.0108
Trichomonas vaginalis Sentrin-specific protease, putative 0.0098 0.0108 0.1122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.0819 0.9241
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.006 0.0047 0.0266
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0026 0.0031
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0125 0.0151 0.6421
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0172 0.0227 0.2481
Loa Loa (eye worm) hypothetical protein 0.0125 0.0151 0.1447
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.006 0.0047 0.0898
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0115 0.0135 0.5617
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0172 0.0227 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0119 0.0956
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.006 0.0047 0.0898
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.006 0.0047 0.0898
Brugia malayi FAT domain containing protein 0.0222 0.0305 0.3437
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0244 0.0341 0.3789
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0585 0.0885 0.2417
Loa Loa (eye worm) hypothetical protein 0.0201 0.0273 0.2635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0055 0.0515
Loa Loa (eye worm) glutathione reductase 0.0046 0.0025 0.0228
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0118 0.014 0.1159
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0172 0.0227 0.2481
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0582 0.0879 0.1131
Schistosoma mansoni survival motor neuron protein 0.0049 0.0031 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0253 0.2783
Loa Loa (eye worm) hypothetical protein 0.0167 0.0218 0.2099
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0582 0.0879 0.0877
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0582 0.0879 0.9932
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0172 0.0227 0.2481
Brugia malayi Probable ClpP-like protease 0.0078 0.0076 0.0839
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0041 0.0018 0.0178
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0049 0.003 0.0104
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0065 0.072
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0749 0.1146 0.1146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0364 0.0532 0.5967
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0033 0.0033
Onchocerca volvulus 0.0049 0.003 0.083
Loa Loa (eye worm) phosphatidylinositol 3 0.0115 0.0135 0.1293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.0819 0.9241
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0115 0.0135 0.1434
Loa Loa (eye worm) phosphatidylinositol 3 0.0537 0.0808 0.7829
Echinococcus granulosus expressed conserved protein 0.0188 0.0251 0.0251
Entamoeba histolytica hypothetical protein 0.0333 0.0483 0.5407
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.006 0.0047 0.0266
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.006 0.0047 0.0898
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0194 0.0261 0.2514
Giardia lamblia Hypothetical protein 0.0115 0.0135 0.1434
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0076 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0585 0.0885 1
Echinococcus multilocularis expressed conserved protein 0.0188 0.0251 0.0249
Toxoplasma gondii thioredoxin reductase 0.0046 0.0025 0.0278
Leishmania major hypothetical protein, unknown function 0.0115 0.0135 0.0347
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0441 0.0655 0.7373
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0244 0.0341 0.0964
Leishmania major hypothetical protein, conserved 0.0109 0.0126 0.0321
Mycobacterium tuberculosis Conserved protein 0.0109 0.0126 0.102
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0041 0.0018 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0525 0.0789 0.8903
Onchocerca volvulus 0.0148 0.0188 0.5415
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0049 0.003 0.0104
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0316 0.0455 0.509
Brugia malayi AMP-binding enzyme family protein 0.0167 0.0218 0.2448
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.032 0.0462 0.517
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0005 0.0005
Brugia malayi Cytochrome P450 family protein 0.006 0.0047 0.0514
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0076 0.0095
Onchocerca volvulus 0.0049 0.003 0.083
Loa Loa (eye worm) oxidoreductase 0.0049 0.003 0.0277
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0049 0.003 0.0238
Loa Loa (eye worm) hypothetical protein 0.02 0.0271 0.2609
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0115 0.0135 0.1575
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0049 0.003 0.0337
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0041 0.0018 0.0186
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0049 0.003 0.0104
Plasmodium vivax sentrin-specific protease 1, putative 0.0041 0.0018 0.0699
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0125 0.0151 1
Echinococcus multilocularis serine protein kinase ATM 0.032 0.0462 0.046
Echinococcus granulosus caspase 3 0.0077 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0104 0.0118 0.1126
Brugia malayi Thioredoxin reductase 0.0046 0.0025 0.0266
Plasmodium falciparum glutathione reductase 0.0046 0.0025 0.0373
Loa Loa (eye worm) hypothetical protein 0.0109 0.0126 0.1202
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0354 0.0517 0.0517
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0126 0.5075
Echinococcus multilocularis sentrin specific protease 8 0.0098 0.0108 0.0106
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0025 0.0056
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0126 0.0126
Echinococcus multilocularis microtubule associated protein 2 0.4898 0.7757 0.7757
Schistosoma mansoni caspase-3 (C14 family) 0.0105 0.012 0.0152
Loa Loa (eye worm) hypothetical protein 0.0086 0.0089 0.0845
Echinococcus multilocularis expressed conserved protein 0.0143 0.018 0.0178
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.006 0.0047 0.0898
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0005 0.0003
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0556 0.0838 0.946
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0049 0.003 0.0612
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0115 0.0135 0.1575
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0582 0.0879 0.0879
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0261 0.0334
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0115 0.0135 0.0365
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.006 0.0047 0.0266
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0556 0.0838 0.2408
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.006 0.0047 0.0266
Schistosoma mansoni hypothetical protein 0.006 0.0047 0.0058
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0172 0.0227 0.2184
Entamoeba histolytica hypothetical protein 0.0484 0.0723 0.8152
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0138 0.1135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0855 0.9662
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0525 0.0789 0.8903
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0049 0.003 0.0337
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0205 0.0279 0.0785
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.02 0.0271 0.2982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0304 0.0436 0.4871
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0244 0.0341 0.3789
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0126 0.102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0562 0.0848 0.9577
Echinococcus granulosus expressed conserved protein 0.0143 0.018 0.018
Echinococcus multilocularis GPCR, family 2 0.0033 0.0005 0.0003
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.002 0.0205
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0076 0.4375
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0115 0.0135 0.1509
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0244 0.0341 0.3843
Loa Loa (eye worm) cytochrome P450 0.006 0.0047 0.044
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0585 0.0885 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0015 0.0068
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0126 0.5504
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0172 0.0227 0.2481
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0049 0.003 0.0104
Loa Loa (eye worm) phosphatidylinositol 3 0.0115 0.0135 0.1293
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0172 0.0227 0.0227
Toxoplasma gondii propionate-CoA ligase 0.0049 0.003 0.0337
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0118 0.014 0.1159
Mycobacterium ulcerans hypothetical protein 0.0167 0.0218 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0244 0.0341 0.3789
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.0674 0.0672
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0445 0.0662 0.7455
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.032 0.0462 0.5212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0562 0.0848 0.9577
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0244 0.0341 0.3789
Leishmania major cytochrome p450-like protein 0.006 0.0047 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0562 0.0848 0.9577
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0041 0.0018 0.0092
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0031 0.0332
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0041 0.0018 0.002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0585 0.0885 0.2417
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.006 0.0047 0.0898
Plasmodium vivax acetyl-CoA synthetase, putative 0.0049 0.003 0.1268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.0819 0.9241
Echinococcus multilocularis 0.006 0.0047 0.0045
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0556 0.0838 0.946
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0126 0.5075
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0025 0.0024
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0046 0.0105
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0172 0.0227 0.2547
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0304 0.0436 0.0436
Loa Loa (eye worm) Ulp1 protease 0.0098 0.0108 0.1028
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0055 0.0131
Loa Loa (eye worm) hypothetical protein 0.0041 0.0018 0.0153
Loa Loa (eye worm) hypothetical protein 0.0304 0.0436 0.4215
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0089 0.0089
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0138 0.1135
Entamoeba histolytica acyl-coA synthetase, putative 0.0167 0.0218 0.2382
Brugia malayi glutathione reductase 0.0046 0.0025 0.0266
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0049 0.003 0.0057
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0585 0.0885 1
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0126 0.102
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.006 0.0047 0.0898
Echinococcus granulosus tar DNA binding protein 0.0194 0.0261 0.0261
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0076 0.2426
Echinococcus multilocularis 0.0115 0.0135 0.0133
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0049 0.003 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0555 0.6226
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0115 0.0135 0.0172
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.006 0.0047 0.0266
Loa Loa (eye worm) TAR-binding protein 0.0194 0.0261 0.2514
Onchocerca volvulus 0.0247 0.0345 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0677 0.1032 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0126 0.016
Echinococcus granulosus Niemann Pick C1 protein 0.02 0.0271 0.0271
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.006 0.0047 0.0898
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0041 0.0018 0.0178
Loa Loa (eye worm) phosphatidylinositol 3 0.0585 0.0885 0.8574
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0167 0.0218 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0076 0.2788
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0445 0.0662 0.7455
Schistosoma mansoni patched 1 0.0086 0.0089 0.0112
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0126 0.102
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0049 0.003 0.0238
Echinococcus multilocularis protein dispatched 1 0.0098 0.0108 0.0106
Mycobacterium ulcerans beta-lactamase 0.0109 0.0126 0.5075
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0172 0.0227 0.2481
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.032 0.0462 0.1316
Toxoplasma gondii ABC1 family protein 0.0109 0.0126 0.1463
Schistosoma mansoni fkbp-rapamycin associated protein 0.0304 0.0436 0.056
Brugia malayi Pre-SET motif family protein 0.0217 0.0298 0.3348
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0261 0.0334
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0115 0.0135 0.0135
Giardia lamblia Phosphatidylinositol 4-kinase 0.0115 0.0135 0.1434
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0049 0.003 0.0104
Echinococcus multilocularis tumor protein p63 0.101 0.1561 0.156
Plasmodium vivax sentrin-specific protease 2, putative 0.0041 0.0018 0.0699
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.006 0.0047 0.0266
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0049 0.003 0.0277
Entamoeba histolytica hypothetical protein 0.0115 0.0135 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0341 0.0495 0.5545
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0076 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.0819 0.9241
Brugia malayi Cytochrome P450 family protein 0.0188 0.0252 0.2831
Plasmodium falciparum thioredoxin reductase 0.0046 0.0025 0.0373
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0172 0.0227 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0172 0.0227 0.0225
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0484 0.0723 0.8152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0055 0.0515
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0115 0.0135 0.0365
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.0339 0.0337
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.001 0.001
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0049 0.003 0.0029
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0025 0.0228
Mycobacterium tuberculosis Conserved protein 0.0109 0.0126 0.102
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0118 0.1313
Schistosoma mansoni transcription factor LCR-F1 0.0333 0.0483 0.062
Leishmania major phosphatidylinositol 3-kinase, putative 0.0172 0.0227 0.06
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0055 0.0515
Schistosoma mansoni hypothetical protein 0.0083 0.0084 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0055 0.0515
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0115 0.0135 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0135 0.1434
Loa Loa (eye worm) hypothetical protein 0.0078 0.0076 0.0719
Loa Loa (eye worm) RNA binding protein 0.0194 0.0261 0.2514
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0126 0.102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0167 0.0218 0.1909
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0126 0.1326
Loa Loa (eye worm) cytochrome P450 family protein 0.0089 0.0094 0.0897
Schistosoma mansoni cellular tumor antigen P53 0.0148 0.0188 0.024
Leishmania major phosphatidylinositol 4-kinase, putative 0.0115 0.0135 0.0347
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0098 0.0108 0.1122
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0049 0.003 0.0061
Trypanosoma brucei SUMO1/Ulp2, putative 0.0041 0.0018 0.0092
Entamoeba histolytica hypothetical protein 0.0115 0.0135 0.1434
Loa Loa (eye worm) hypothetical protein 0.0222 0.0305 0.2947
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0115 0.0135 0.0365
Echinococcus granulosus microtubule associated protein 2 0.4898 0.7757 0.7757
Brugia malayi RNA recognition motif domain containing protein 0.0194 0.0261 0.2932
Giardia lamblia Sentrin specific protease, putative 0.0041 0.0018 0.0092
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.0339 0.0339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0548 0.0826 0.9326
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.006 0.0047 0.0898
Echinococcus granulosus Niemann Pick C1 protein 0.0285 0.0407 0.0407
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0041 0.0018 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0089 0.0907
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0126 0.0124
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0098 0.0108 0.0137
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.001 0.0008
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0089 0.0087
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.006 0.0047 0.0898
Leishmania major cathepsin L-like protease 0.0064 0.0055 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0018 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0345 0.0502 0.563
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0115 0.0135 0.1509
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0172 0.0227 0.2481
Leishmania major cytochrome p450-like protein 0.0089 0.0094 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0855 0.9662
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0049 0.003 0.0061
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0033 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.0818 0.924
Schistosoma mansoni hypothetical protein 0.0115 0.0135 0.0172
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0119 0.0956
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0126 0.1326
Loa Loa (eye worm) beta-lactamase 0.0109 0.0126 0.1202
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0049 0.003 0.0238
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.0075
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0374 0.0548 0.6147
Mycobacterium ulcerans lipase LipD 0.0109 0.0126 0.5075
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0115 0.0135 0.5923
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0089 0.0094 0.34
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0041 0.0018 0.0092
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0005 0.0005
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0076 0.5
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0041 0.0018 0.0092
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.003 0.0104
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0089 0.0845
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0244 0.0341 0.3789
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0556 0.0838 0.9465
Trypanosoma cruzi hypothetical protein, conserved 0.2195 0.3449 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.001 0.0008
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0222 0.0305 0.0305
Echinococcus granulosus sentrin specific protease 7 0.0184 0.0245 0.0245
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0041 0.0018 0.0178
Echinococcus multilocularis sentrin specific protease 1 0.0041 0.0018 0.0016
Loa Loa (eye worm) CYP4Cod1 0.0089 0.0094 0.0897
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0118 0.1313
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.0305 0.3379
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0354 0.0517 0.5831
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0005 0.0032
Entamoeba histolytica hypothetical protein 0.0333 0.0483 0.5407
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0115 0.0135 0.5923
Leishmania major lanosterol 14-alpha-demethylase, putative 0.006 0.0047 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0336 0.0488 0.5467
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0172 0.0227 0.0632
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0567 0.0856 0.2336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0855 0.9662
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0585 0.0885 0.0883
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.006 0.0047 0.0266
Entamoeba histolytica acyl-CoA synthetase, putative 0.0167 0.0218 0.2382
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0172 0.0227 0.0227
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0118 0.014 0.1159
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0076 0.0875
Entamoeba histolytica hypothetical protein 0.0333 0.0483 0.5407
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0304 0.0436 0.124
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0033 0.0031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0118 0.1126
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0041 0.0018 0.0092
Loa Loa (eye worm) hypothetical protein 0.0354 0.0517 0.5
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0041 0.0018 0.0023
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0167 0.0218 0.2099
Brugia malayi cytochrome P450 0.006 0.0047 0.0514
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0049 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.0115 0.0135 0.1293
Loa Loa (eye worm) cytochrome P450 family protein 0.0188 0.0252 0.2427
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0005 0.0032
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.006 0.0047 0.0266
Brugia malayi AMP-binding enzyme family protein 0.0049 0.003 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0562 0.0848 0.9577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0525 0.0789 0.8903
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0129 0.0158 0.0433
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0049 0.003 0.0104
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0126 0.5075
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0138 0.5709
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0041 0.0018 0.0092

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) > 25 uM Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay ChEMBL. 19410457
EC50 (binding) > 25 uM Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins by Western blot analysis ChEMBL. 22233320

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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