Detailed information for compound 1104463

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1390.79 | Formula: C83H107N9O10
  • H donors: 10 H acceptors: 8 LogP: 9.88 Rotable bonds: 27
    Rule of 5 violations (Lipinski): 3
  • SMILES: Oc1ccc2c3c1OC1C43CCN(C(C2)[C@]4(O)Cc2c1[nH]c1c2C[C@@]2(C34C1Oc1c4c(C[C@H]2N(CC3)CC2CC2)ccc1O)O)CC1CC1.CCCCC(=N)NCCCCCNC(=O)C(NC(=O)CNC(=O)[C@@]1(CC1CN1CC[C@@]2(C(C1Cc1c2cc(cc1)O)C)C)c1ccccc1)CC(C)C
  • InChi: 1S/C43H64N6O4.C40H43N3O6/c1-6-7-16-38(44)45-20-12-9-13-21-46-40(52)36(23-29(2)3)48-39(51)27-47-41(53)43(32-14-10-8-11-15-32)26-33(43)28-49-22-19-42(5)30(4)37(49)24-31-17-18-34(50)25-35(31)42;44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19/h8,10-11,14-15,17-18,25,29-30,33,36-37,50H,6-7,9,12-13,16,19-24,26-28H2,1-5H3,(H2,44,45)(H,46,52)(H,47,53)(H,48,51);5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2/t30?,33?,36?,37?,42-,43+;27-,28?,35?,36?,37?,38?,39-,40-/m11/s1
  • InChiKey: AAOBMVQXRCDSEM-VAZQSKQPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0082 0.0107 0.03
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0011 0.0062
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0026 0.0026
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0011 0.0062
Schistosoma mansoni cpg binding protein 0.0066 0.0081 0.0336
Echinococcus multilocularis Zinc finger, PHD finger 0.0082 0.0107 0.0107
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0011 0.0062
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0082 0.0107 0.1475
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0082 0.0107 0.1592
Loa Loa (eye worm) intermediate filament protein 0.003 0.0022 0.0327
Schistosoma mansoni ap endonuclease 0.0022 0.0009 0.0038
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0043 0.0043
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0426 0.0671 0.3753
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0082 0.0107 0.1592
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0069 0.2465
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0327
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0011 0.0062
Loa Loa (eye worm) hypothetical protein 0.0178 0.0265 0.3943
Loa Loa (eye worm) phosphatidylinositol 3 0.0426 0.0671 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0348 0.0544 0.8082
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.008 0.0103 0.3862
Onchocerca volvulus 0.0023 0.0011 0.0235
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0143 0.2134
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0426 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0103 0.1533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0107 0.1475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0057 0.0066 0.0272
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0038 0.0561
Schistosoma mansoni pyruvate kinase 0.004 0.0038 0.0156
Trypanosoma brucei ribonuclease H1 0.0294 0.0456 0.2544
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0011 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0018 0.0132
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0109
Loa Loa (eye worm) phosphatidylinositol 3 0.0082 0.0107 0.1592
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Echinococcus multilocularis protein dispatched 1 0.0057 0.0067 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0069 0.2465
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0006 0.0006
Loa Loa (eye worm) mbt repeat family protein 0.0057 0.0066 0.0979
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0011 0.0715
Trypanosoma brucei unspecified product 0.032 0.0497 0.2774
Loa Loa (eye worm) MH2 domain-containing protein 0.0142 0.0206 0.3069
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0003 0.0049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0026 0.0026
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0082 0.0107 0.0107
Echinococcus granulosus pyruvate kinase 0.002 0.0006 0.0006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0069 0.0069
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0082 0.0107 0.1475
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0069 0.0184
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0025 0.0013 0.0064
Brugia malayi reverse transcriptase 0.0025 0.0013 0.02
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0065 0.0079 0.1171
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0082 0.0107 0.1475
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0007 0.0104
Loa Loa (eye worm) hypothetical protein 0.0282 0.0435 0.6481
Mycobacterium ulcerans pyruvate kinase 0.004 0.0038 0.1174
Brugia malayi RNase H family protein 0.0294 0.0456 0.6789
Brugia malayi mbt repeat family protein 0.0057 0.0066 0.0979
Echinococcus granulosus neuropeptide receptor A26 0.0977 0.1576 0.1576
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0003 0.0005
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0426 0.0671 0.1923
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0025 0.0013 0.0013
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0025 0.0013 0.0114
Echinococcus multilocularis musashi 0.003 0.0022 0.0022
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0107 0.03
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0082 0.0107 0.0586
Loa Loa (eye worm) MBCTL1 0.0065 0.0079 0.1171
Echinococcus granulosus pyruvate kinase 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0178 0.0265 0.3943
Brugia malayi reverse transcriptase 0.0025 0.0013 0.02
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0082 0.0107 0.03
Loa Loa (eye worm) hypothetical protein 0.0046 0.0047 0.0707
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0082 0.0107 0.1475
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0107 0.0586
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0011 0.0298
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.6112 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0082 0.0107 0.1475
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0103 0.1415
Brugia malayi hypothetical protein 0.0025 0.0013 0.02
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0082 0.0107 0.1475
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0003 0.0003
Echinococcus granulosus pyruvate kinase 0.004 0.0038 0.0038
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0067 0.0995
Plasmodium falciparum pyruvate kinase 2 0.002 0.0006 0.025
Brugia malayi AMP-binding enzyme family protein 0.008 0.0103 0.1533
Loa Loa (eye worm) hypothetical protein 0.0268 0.0411 0.6131
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0009 0.0019
Schistosoma mansoni hypothetical protein 0.0945 0.1523 0.6297
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Loa Loa (eye worm) pyruvate kinase 0.004 0.0038 0.0561
Plasmodium vivax acyl-CoA synthetase, putative 0.0059 0.007 0.6431
Echinococcus multilocularis zinc finger protein 0.0027 0.0017 0.0017
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0011 0.0298
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0006 0.0024
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0103 0.0278
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0038 0.043
Echinococcus granulosus KRAB A domain containing protein 0.0025 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0082 0.0107 0.1475
Loa Loa (eye worm) hypothetical protein 0.0071 0.0089 0.1329
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0107 0.0289
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0117 0.0165 0.2354
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0426 0.0671 0.1923
Echinococcus granulosus Niemann Pick C1 protein 0.0117 0.0165 0.0165
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0025 0.0013 0.0114
Brugia malayi hypothetical protein 0.0282 0.0435 0.6481
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0159
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0011 0.0047
Echinococcus multilocularis microtubule associated protein 2 0.1491 0.2419 0.2419
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0038 0.0826
Brugia malayi MH2 domain containing protein 0.0142 0.0206 0.3069
Trichomonas vaginalis reverse transcriptases, putative 0.0025 0.0013 0.0064
Entamoeba histolytica protein kinase rad3, putative 0.024 0.0366 0.5397
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0082 0.0107 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0426 0.0671 0.0671
Brugia malayi Zinc knuckle family protein 0.0025 0.0013 0.02
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0003 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 0.0062
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0059 0.007 0.268
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0109
Echinococcus granulosus lamin dm0 0.003 0.0022 0.0022
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0411 0.6078
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0082 0.0107 0.03
Brugia malayi Zinc knuckle family protein 0.0025 0.0013 0.02
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0043 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0366 0.5397
Trypanosoma brucei RNA helicase, putative 0.1104 0.1784 1
Plasmodium vivax pyruvate kinase, putative 0.004 0.0038 0.3318
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.024 0.0366 0.546
Echinococcus granulosus lamin 0.003 0.0022 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0107 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0215
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 0.0062
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0082 0.0107 0.0441
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0008 0.0034
Schistosoma mansoni hypothetical protein 0.0202 0.0304 0.1256
Loa Loa (eye worm) hypothetical protein 0.0055 0.0062 0.0924
Schistosoma mansoni cpg binding protein 0.0072 0.0091 0.0377
Echinococcus granulosus intermediate filament protein 0.003 0.0022 0.0022
Loa Loa (eye worm) pyruvate kinase 0.004 0.0038 0.0561
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 0.0062
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0011 0.0023
Mycobacterium ulcerans fatty-acid-CoA ligase 0.008 0.0103 0.3862
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0082 0.0107 0.1475
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0186 0.0277 0.0277
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0082 0.0107 0.1475
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0366 0.5397
Echinococcus multilocularis neuropeptide s receptor 0.0977 0.1576 0.1576
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0011 0.0023
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0426 0.0671 0.3753
Schistosoma mansoni phosphoglucomutase 0.0294 0.0456 0.1883
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0043 0.0043
Onchocerca volvulus 0.003 0.0022 0.0481
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0159
Echinococcus granulosus SAM and MBT domain containing protein 0.0057 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0071 0.0089 0.0368
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0082 0.0107 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0003 0.0005
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0031 0.0023 0.0094
Schistosoma mansoni pyruvate kinase 0.004 0.0038 0.0156
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.024 0.0366 0.5397
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0013 0.0013
Echinococcus multilocularis sterol regulatory element binding protein 0.005 0.0055 0.0055
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0006 0.0024
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0103 0.3824
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.007 0.2503
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0081 0.1212
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Loa Loa (eye worm) hypothetical protein 0.0049 0.0052 0.0776
Echinococcus multilocularis Niemann Pick C1 protein 0.0168 0.0248 0.0248
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0082 0.0107 0.1592
Schistosoma mansoni hypothetical protein 0.1104 0.1784 0.7375
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0394
Loa Loa (eye worm) hypothetical protein 0.0059 0.007 0.1041
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0009 0.0568
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0082 0.0107 0.0441
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0011 0.0159
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0082 0.0107 0.1517
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0082 0.0107 0.155
Loa Loa (eye worm) hypothetical protein 0.005 0.0055 0.082
Brugia malayi hypothetical protein 0.0025 0.0013 0.02
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0038 0.0514
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0018 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0159
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0082 0.0107 0.1475
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0103 0.0278
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0009 0.002
Trypanosoma cruzi target of rapamycin kinase 3 0.0426 0.0671 0.1923
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0005 0.0083
Leishmania major pyruvate kinase 0.004 0.0038 0.0098
Schistosoma mansoni hypothetical protein 0.0025 0.0013 0.0056
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0082 0.0107 0.0107
Leishmania major hypothetical protein, unknown function 0.0082 0.0107 0.0289
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0011 0.0159
Loa Loa (eye worm) hypothetical protein 0.0084 0.0111 0.165
Echinococcus multilocularis SAM and MBT domain containing protein 0.0057 0.0066 0.0066
Brugia malayi hypothetical protein 0.0025 0.0013 0.02
Echinococcus granulosus GPCR family 2 0.0033 0.0026 0.0026
Mycobacterium ulcerans hypothetical protein 0.008 0.0103 0.3862
Loa Loa (eye worm) phosphatidylinositol kinase 0.0082 0.0107 0.1592
Loa Loa (eye worm) hypothetical protein 0.0062 0.0074 0.1097
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0059 0.007 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0013 0.0013
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0967 0.1558 0.1558
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0109
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0026 0.0394
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0109
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0082 0.0107 1
Schistosoma mansoni lamin 0.003 0.0022 0.0091
Schistosoma mansoni hypothetical protein 0.035 0.0547 0.2261
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0025 0.0013 0.0013
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0009 0.0137
Schistosoma mansoni phosphoglucomutase 0.0294 0.0456 0.1883
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0065 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0267
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0215
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0082 0.0107 0.03
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.008 0.0103 0.4008
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0011 0.0111
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0075 0.0095 0.0095
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0426 0.0671 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0025 0.0013 0.0064
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0003 0.0014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0426 0.0671 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0366 0.5397
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0026 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0348 0.0544 0.8082
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0426 0.0671 0.2774
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0348 0.0544 0.8082
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0011 0.0298
Echinococcus multilocularis polycomb protein SCMH1 0.0057 0.0066 0.0066
Echinococcus granulosus microtubule associated protein 2 0.1491 0.2419 0.2419
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0011 0.0298
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0082 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0979
Loa Loa (eye worm) hypothetical protein 0.0117 0.0165 0.2458
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0082 0.0107 1
Echinococcus granulosus zinc finger protein 0.0027 0.0017 0.0017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0103 0.1533
Echinococcus granulosus polycomb protein SCMH1 0.0057 0.0066 0.0066
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.017 0.0252 1
Toxoplasma gondii FATC domain-containing protein 0.024 0.0366 0.5438
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0082 0.0107 0.1475
Leishmania major phosphatidylinositol 4-kinase, putative 0.0082 0.0107 0.0289
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0082 0.0107 0.1475
Echinococcus multilocularis lamin 0.003 0.0022 0.0022
Plasmodium vivax hypothetical protein 0.0082 0.0107 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0082 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.0043 0.0043 0.0177
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0082 0.0107 0.1475
Echinococcus multilocularis survival motor neuron protein 1 0.0282 0.0435 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0082 0.0107 0.1592
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0141 0.0203 0.0841
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0025 0.0013 0.0056
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0025 0.0013 0.0013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.024 0.0366 0.546
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0066 0.0272
Loa Loa (eye worm) hypothetical protein 0.0065 0.0079 0.1171
Brugia malayi RNase H family protein 0.0294 0.0456 0.6789
Schistosoma mansoni survival motor neuron protein 0.0057 0.0067 0.0276
Giardia lamblia GTOR 0.0426 0.0671 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0082 0.0107 0.03
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0561
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0026 0.0394
Brugia malayi Niemann-Pick C1 protein precursor 0.0117 0.0165 0.2458
Echinococcus multilocularis dnaJ subfamily B 0.0945 0.1523 0.1523
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0082 0.0107 0.1475
Brugia malayi AMP-binding enzyme family protein 0.008 0.0103 0.1533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0107 0.1475
Brugia malayi CXXC zinc finger family protein 0.0066 0.0081 0.1212
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0294 0.0456 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0348 0.0544 0.8082
Brugia malayi RNase H family protein 0.0294 0.0456 0.6789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0003 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0082 0.0107 0.0441
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0426 0.0671 0.1923
Brugia malayi FAT domain containing protein 0.0186 0.0277 0.4128
Onchocerca volvulus 0.0057 0.0067 0.1465
Echinococcus granulosus geminin 0.0202 0.0304 0.0304
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 0.0062
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0069 0.2643
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0082 0.0107 0.1475
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0366 0.5397
Brugia malayi Bromodomain containing protein 0.0046 0.0047 0.0705
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0022 0.0327
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.008 0.0103 0.3862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0158 0.0232 0.3367
Echinococcus multilocularis pyruvate kinase 0.002 0.0006 0.0006
Echinococcus granulosus survival motor neuron protein 1 0.0282 0.0435 0.0435
Echinococcus multilocularis muscleblind protein 1 0.0178 0.0265 0.0265
Brugia malayi reverse transcriptase 0.0025 0.0013 0.02
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0082 0.0107 0.1592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0082 0.0107 0.1592
Schistosoma mansoni hypothetical protein 0.0057 0.0067 0.0276
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0003 0.0003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0075 0.0095 0.0095
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0082 0.0107 0.155
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0069 0.0983
Onchocerca volvulus 0.0082 0.0107 0.2344
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0082 0.0107 0.1475
Echinococcus multilocularis pyruvate kinase 0.0031 0.0024 0.0024
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0268 0.0411 0.6112
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0011 0.0062
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0426 0.0671 0.1851
Trypanosoma cruzi ribonuclease H1, putative 0.0294 0.0456 0.1303
Onchocerca volvulus 0.0025 0.0013 0.0295
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0082 0.0107 0.03
Echinococcus granulosus Niemann Pick C1 protein 0.0168 0.0248 0.0248
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0025 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0313
Plasmodium falciparum pyruvate kinase 0.004 0.0038 0.3318
Trichomonas vaginalis reverse transcriptases, putative 0.0025 0.0013 0.0064
Giardia lamblia Reverse transcriptase/endonuclease 0.0025 0.0013 0.0114
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0006 0.0006
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0011 0.0298
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0089 0.1329
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0011 0.0023
Treponema pallidum ribonuclease H (rnhA) 0.0294 0.0456 0.8346
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0069 0.2465
Echinococcus granulosus sterol regulatory element binding protein 0.005 0.0055 0.0055
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0038 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0268 0.0411 0.6078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0065 0.2466
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0009 0.0568
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0082 0.0107 0.0107
Entamoeba histolytica acyl-coA synthetase, putative 0.008 0.0103 0.1415
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Loa Loa (eye worm) oxidoreductase 0.0023 0.0011 0.0159
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0011 0.0298
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0103 0.4008
Toxoplasma gondii target of rapamycin (TOR), putative 0.0426 0.0671 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0143 0.2134
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0003 0.0003
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0011 0.0023
Echinococcus multilocularis lamin dm0 0.003 0.0022 0.0022
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0103 0.0278
Echinococcus multilocularis Niemann Pick C1 protein 0.0117 0.0165 0.0165
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0038 0.0826
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0082 0.0107 0.0441
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0366 0.5397
Giardia lamblia Phosphatidylinositol 4-kinase 0.0082 0.0107 0.1517
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.024 0.0366 0.1515
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0348 0.0544 0.8082
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.024 0.0366 0.1047
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0065 0.0079 0.0079
Schistosoma mansoni bromodomain containing protein 0.0079 0.0102 0.0423
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0009 0.002
Trypanosoma brucei ingi protein (ORF1) 0.032 0.0497 0.2774
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0038 0.1118
Entamoeba histolytica hypothetical protein 0.0082 0.0107 0.1475
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0426 0.0671 0.1923
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0082 0.0107 0.155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0426 0.0671 0.1851
Echinococcus multilocularis expressed conserved protein 0.011 0.0153 0.0153
Schistosoma mansoni protein kinase 0.0025 0.0013 0.0056
Toxoplasma gondii ribonuclease HI protein 0.0294 0.0456 0.6773
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.032 0.0497 0.2774
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0013 0.0056
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0025 0.0013 0.0062
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0082 0.0107 0.1592
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0103 0.3862
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0426 0.0671 0.0671
Echinococcus granulosus neuropeptide s receptor 0.0977 0.1576 0.1576
Schistosoma mansoni ap endonuclease 0.0022 0.0009 0.0038
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0011 0.0298
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0038 0.0102
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0082 0.0107 0.1475
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0082 0.0107 1
Schistosoma mansoni intermediate filament proteins 0.003 0.0022 0.0091
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0082 0.0107 0.03
Loa Loa (eye worm) phosphatidylinositol 3 0.0082 0.0107 0.1592
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.008 0.0103 0.3862
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0426 0.0671 0.1851
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0013 0.0013
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0011 0.0024
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0082 0.0107 0.1475
Echinococcus granulosus Protein patched homolog 1 0.005 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0055 0.0693
Brugia malayi isocitrate dehydrogenase 0.0019 0.0003 0.0049
Echinococcus granulosus RNA directed DNA polymerase 0.0025 0.0013 0.0013
Echinococcus granulosus expressed conserved protein 0.011 0.0153 0.0153
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0082 0.0107 0.0441
Loa Loa (eye worm) hypothetical protein 0.0082 0.0107 0.1592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Brugia malayi Muscleblind-like protein 0.0178 0.0265 0.3943
Brugia malayi PHD-finger family protein 0.0033 0.0027 0.0407
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0011 0.0062
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0066 0.0272
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0022 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0366 0.5397
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.0277 0.4047
Echinococcus multilocularis RNA directed DNA polymerase 0.0025 0.0013 0.0013
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0011 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0022 0.0008 0.0008
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0013 0.0013
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0011 0.0298
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0426 0.0671 0.3753
Schistosoma mansoni zinc finger protein 0.0027 0.0017 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0011 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Echinococcus multilocularis serine protein kinase ATM 0.024 0.0366 0.0366
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0229 0.0347 0.0347
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Entamoeba histolytica hypothetical protein 0.0043 0.0043 0.0507
Schistosoma mansoni hypothetical protein 0.0082 0.0107 0.0441
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.024 0.0366 0.0366
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0011 0.0159
Brugia malayi CHE-14 protein 0.005 0.0055 0.082
Schistosoma mansoni hypothetical protein 0.0018 0.0002 0.001
Leishmania major pyruvate kinase 0.004 0.0038 0.0098
Echinococcus granulosus serine protein kinase ATM 0.024 0.0366 0.0366
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0011 0.0023
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0069 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Entamoeba histolytica hypothetical protein 0.0082 0.0107 0.1475
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0082 0.0107 0.0107
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0159
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0082 0.0107 0.155
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0025 0.0013 0.0062
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0426 0.0671 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0009 0.0237
Loa Loa (eye worm) hypothetical protein 0.0059 0.007 0.1041
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0229 0.0347 0.0347
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0348 0.0544 0.8082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0348 0.0544 0.8082
Entamoeba histolytica hypothetical protein 0.0082 0.0107 0.1475
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.024 0.0366 0.2043
Schistosoma mansoni zinc finger protein 0.0018 0.0002 0.001
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0082 0.0107 0.1592
Mycobacterium tuberculosis Possible maturase 0.0025 0.0013 0.0408
Mycobacterium leprae conserved hypothetical protein 0.0082 0.0107 0.3989
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.017 0.0252 1
Entamoeba histolytica hypothetical protein 0.024 0.0366 0.5397
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.024 0.0366 0.1047
Echinococcus granulosus histone acetyltransferase MYST2 0.0065 0.0079 0.0079
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0348 0.0544 0.8082
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0025 0.0013 0.0114
Echinococcus granulosus muscleblind protein 0.0178 0.0265 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0082 0.0107 0.1592
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0348 0.0544 0.8082
Leishmania major phosphatidylinositol kinase, putative 0.0082 0.0107 0.0289
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0038 0.0561
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0011 0.0062
Echinococcus multilocularis 0.0082 0.0107 0.0107
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0006 0.0039
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0082 0.0107 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Onchocerca volvulus 0.0023 0.0011 0.0235
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0082 0.0107 0.0586
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0082 0.0107 0.0586
Loa Loa (eye worm) phosphatidylinositol 3 0.0426 0.0671 1
Brugia malayi intermediate filament protein 0.003 0.0022 0.0327
Schistosoma mansoni pyruvate kinase 0.002 0.0006 0.0024
Brugia malayi mbt repeat family protein 0.0057 0.0066 0.0979
Brugia malayi hypothetical protein 0.0043 0.0043 0.0637
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0011 0.0047
Plasmodium falciparum acyl-CoA synthetase 0.0059 0.007 0.6431
Trypanosoma cruzi hypothetical protein, conserved 0.2138 0.348 1
Onchocerca volvulus 0.0025 0.0013 0.0295
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0031 0.0023 0.0023
Leishmania major phosphatidylinositol kinase related protein, putative 0.0082 0.0107 0.0289
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0025 0.0013 0.0013
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0426 0.0671 0.3753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.0232 0.3367
Onchocerca volvulus 0.0082 0.0107 0.2344
Loa Loa (eye worm) phosphatidylinositol 3 0.0082 0.0107 0.1592
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0043 0.0043
Schistosoma mansoni cpg binding protein 0.0072 0.0091 0.0377
Trypanosoma brucei pyruvate kinase 1 0.004 0.0038 0.0198
Loa Loa (eye worm) hypothetical protein 0.008 0.0103 0.1533
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0158 0.0232 0.066
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0082 0.0107 0.1517
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0026 0.0026
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0082 0.0107 0.0107
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0103 0.3824
Schistosoma mansoni hypothetical protein 0.0202 0.0304 0.1256
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0013 0.0013
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0426 0.0671 0.2774
Loa Loa (eye worm) transcription factor SMAD2 0.0142 0.0206 0.3069
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 0.0062
Mycobacterium tuberculosis Conserved hypothetical protein 0.0082 0.0107 0.4168
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0159
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0186 0.0277 0.0277
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0082 0.0107 0.0441
Leishmania major hypothetical protein, conserved 0.222 0.3614 1
Schistosoma mansoni patched 1 0.005 0.0055 0.0227
Onchocerca volvulus 0.0023 0.0011 0.0235
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0011 0.0024
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0082 0.0107 0.0107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0348 0.0544 0.8082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0107 0.1475
Echinococcus multilocularis pyruvate kinase 0.004 0.0038 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0143 0.2134
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0082 0.0107 0.1592
Onchocerca volvulus Ribonuclease H1 homolog 0.0294 0.0456 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0011 0.0024
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0082 0.0107 0.1475
Echinococcus multilocularis GPCR, family 2 0.0033 0.0026 0.0026
Trypanosoma cruzi ribonuclease H1, putative 0.0294 0.0456 0.1303
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0038 0.1383
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0065 0.2466
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0013 0.0032
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0011 0.0023
Echinococcus multilocularis cpg binding protein 0.0072 0.0091 0.0091
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0026 0.0394
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0082 0.0107 0.0107
Echinococcus multilocularis geminin 0.0202 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0121
Loa Loa (eye worm) hypothetical protein 0.0059 0.007 0.1041
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0082 0.0107 0.0107
Echinococcus multilocularis protein patched 0.005 0.0055 0.0055
Treponema pallidum fructose-bisphosphate aldolase 0.0348 0.0544 1
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0038 0.0198
Entamoeba histolytica hypothetical protein 0.0043 0.0043 0.0507
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0009 0.014
Onchocerca volvulus 0.0066 0.0081 0.1785
Toxoplasma gondii exonuclease III APE 0.0022 0.0009 0.0088
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0426 0.0671 0.1851
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0082 0.0107 0.1475
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0025 0.0013 0.0295
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0011 0.0159
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0103 0.3862
Echinococcus multilocularis neuropeptide receptor A26 0.0977 0.1576 0.1576
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0011 0.0011
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0082 0.0107 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0065 0.0079 0.0325
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0268 0.0411 0.2296
Echinococcus multilocularis muscleblind protein 0.0178 0.0265 0.0265
Schistosoma mansoni fkbp-rapamycin associated protein 0.024 0.0366 0.1515
Toxoplasma gondii histone lysine methyltransferase SET1 0.0129 0.0183 0.2696
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0003 0.0003
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0038 0.0826
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0069 0.0285
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0119 0.0168 0.0694
Echinococcus granulosus fetal alzheimer antigen falz 0.0031 0.0023 0.0023
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0426 0.0671 0.1851
Giardia lamblia Hypothetical protein 0.0082 0.0107 0.1517
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0011 0.0298
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0025 0.0013 0.0114
Onchocerca volvulus 0.0057 0.0066 0.1442
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0013 0.019
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.017 0.0252 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0011 0.0111
Trypanosoma brucei ingi protein (ORF1) 0.032 0.0497 0.2774
Onchocerca volvulus 0.008 0.0103 0.2257
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Echinococcus granulosus dnaJ subfamily B 0.0945 0.1523 0.1523
Loa Loa (eye worm) hypothetical protein 0.0158 0.0232 0.3457
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0366 0.5397
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0103 0.1415
Onchocerca volvulus 0.0023 0.0011 0.0235
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0103 0.3862
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0003 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0143 0.2134
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0013 0.0013
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0006 0.0091
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0082 0.0107 0.0107
Schistosoma mansoni lamin 0.003 0.0022 0.0091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0065 0.2466
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0009 0.0039
Leishmania major ribonuclease H1, putative 0.0294 0.0456 0.1255
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0009 0.0137
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0003 0.0003
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0025 0.0013 0.0062
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0082 0.0107 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 0.0062
Loa Loa (eye worm) hypothetical protein 0.0059 0.007 0.1041
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0011 0.0298
Giardia lamblia Fructose-bisphosphate aldolase 0.0348 0.0544 0.8091
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0082 0.0107 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0011 0.0111
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0426 0.0671 0.0671
Echinococcus multilocularis ribonuclease H1 0.0294 0.0456 0.0456
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0082 0.0107 0.1475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Schistosoma mansoni hypothetical protein 0.0025 0.0013 0.0056
Schistosoma mansoni phosphoglucomutase 0.0294 0.0456 0.1883
Echinococcus multilocularis pyruvate kinase 0.002 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0107 0.03
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0065 0.2466
Schistosoma mansoni hypothetical protein 0.0186 0.0277 0.1145
Echinococcus granulosus ribonuclease H1 0.0294 0.0456 0.0456
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0082 0.0107 0.0107
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0082 0.0107 0.0441
Echinococcus granulosus pyruvate kinase 0.004 0.0038 0.0038
Leishmania major phosphatidylinositol 3-kinase, putative 0.0082 0.0107 0.0289
Giardia lamblia Ribonuclease H 0.0294 0.0456 0.6761
Echinococcus granulosus serine:threonine protein kinase SMG1 0.024 0.0366 0.0366
Echinococcus multilocularis pyruvate kinase 0.002 0.0006 0.0006
Onchocerca volvulus 0.003 0.0022 0.0481
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0426 0.0671 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0006 0.025
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 0.0062
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0038 0.043
Brugia malayi AMP-binding enzyme family protein 0.008 0.0103 0.1533
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 0.0062
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0215
Trypanosoma brucei hypothetical protein, conserved 0.032 0.0497 0.2774
Loa Loa (eye worm) hypothetical protein 0.0059 0.007 0.1041
Echinococcus multilocularis histone acetyltransferase MYST2 0.0065 0.0079 0.0079
Brugia malayi hypothetical protein 0.0025 0.0013 0.02
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0186 0.0277 0.4128
Brugia malayi Bromodomain containing protein 0.0093 0.0125 0.1867
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0009 0.005
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0008 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0366 0.5397
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0426 0.0671 0.3753
Echinococcus granulosus pyruvate kinase 0.002 0.0006 0.0006
Schistosoma mansoni microtubule-associated protein tau 0.1491 0.2419 1
Schistosoma mansoni hypothetical protein 0.0025 0.0013 0.0053
Entamoeba histolytica hypothetical protein 0.0043 0.0043 0.0507
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0025 0.0013 0.0013
Loa Loa (eye worm) pyruvate kinase 0.004 0.0038 0.0561
Echinococcus multilocularis pyruvate kinase 0.004 0.0038 0.0038
Echinococcus granulosus histone lysine methyltransferase setb 0.0022 0.0008 0.0008
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.005 0.0055 0.082
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0011 0.0062
Loa Loa (eye worm) hypothetical protein 0.024 0.0366 0.546
Giardia lamblia Pyruvate kinase 0.004 0.0038 0.0477
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0069 0.0285
Echinococcus granulosus cpg binding protein 0.0072 0.0091 0.0091
Entamoeba histolytica hypothetical protein 0.0043 0.0043 0.0507
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0003 0.0003
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0011 0.0298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0025 0.0013 0.02
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0082 0.0107 0.155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0426 0.0671 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0057 0.0066 0.1442
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0082 0.0107 0.1592
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0082 0.0107 0.1475
Trichomonas vaginalis ribonuclease H1, putative 0.0294 0.0456 0.6745
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0011 0.0044

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) mg kg-1 Antinociceptive activity by measuring effective dose after 10 mg/kg of nor-BNI administered subcutaneously 10 min before agonist administered in mouse; Full antagonism of the pharmacological effect produced by the ED50 dose of the agonist ChEMBL. 10956208
ED50 (functional) mg kg-1 Effective dose after 10 mg/kg of nor-BNI administered subcutaneously 10 min before agonist administered in mouse rotarod test; Full antagonism of the pharmacological effect produced by the ED50 dose of the agonist ChEMBL. 10956208

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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