TDR Targets

Basic information

Technical information

TDR Targets ID: 111668
Name: 2-[4-[[(2Z)-2-hydroxyiminocyclohexyl]methyl]p henyl]propanoic acid
MW: 275.343 | Formula: C16H21NO3
H donors: 2 H acceptors: 3 LogP: 3.22 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O/N=C\1/CCCCC1Cc1ccc(cc1)C(C(=O)O)C
InChi: 1S/C16H21NO3/c1-11(16(18)19)13-8-6-12(7-9-13)10-14-4-2-3-5-15(14)17-20/h6-9,11,14,20H,2-5,10H2,1H3,(H,18,19)/b17-15-
InChiKey: KWNVJIHRVMOOPH-ICFOKQHNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[4-[[(2Z)-2-hydroximinocyclohexyl]methyl]phenyl]propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0039	0.077	0.077
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0516	0.0726
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0042	0.0823	0.0823
Echinococcus granulosus	glycoprotein Antigen 5	0.0039	0.077	0.077
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0303	0.1988
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0071	0.0071
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0042	0.0823	0.0823
Onchocerca volvulus		0.0019	0.0278	0.2026
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0042	0.0823	0.0823
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0064	0.1364	0.1364
Loa Loa (eye worm)	trypsin family protein	0.0039	0.077	0.0738
Onchocerca volvulus		0.0034	0.0648	0.5091
Mycobacterium leprae	Conserved hypothetical protein	0.0018	0.0269	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0823	1
Toxoplasma gondii	kringle domain-containing protein	0.0059	0.124	0.1595
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0039	0.077	0.077
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0121	0.2722	0.2722
Onchocerca volvulus		0.0039	0.077	0.6098
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0071	0.0056
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0071	0.0056
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0257	0.0257
Brugia malayi	nuclear receptor NHR-88	0.001	0.0071	0.0056
Onchocerca volvulus		0.0039	0.077	0.6098
Schistosoma mansoni	zinc finger protein	0.0016	0.0213	0.0213
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0018	0.0269	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0037
Entamoeba histolytica	recQ family helicase, putative	0.002	0.0303	0.3176
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0037
Onchocerca volvulus		0.0034	0.0648	0.5091
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0018	0.0269	1
Echinococcus multilocularis	sterol O acyltransferase 1	0.0425	1	1
Onchocerca volvulus		0.0029	0.0516	0.4
Mycobacterium ulcerans	hypothetical protein	0.0039	0.077	1
Brugia malayi	Bloom's syndrome protein homolog	0.002	0.0303	0.0405
Schistosoma mansoni	hypothetical protein	0.0018	0.0269	0.0269
Trypanosoma brucei	RNA helicase, putative	0.0101	0.2245	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0018	0.0269	1
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0272	0.0239
Brugia malayi	PAN domain containing protein	0.0034	0.0648	0.0924
Brugia malayi	PAN domain containing protein	0.0034	0.0648	0.0924
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0037
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0018	0.0269	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0303	0.0405
Onchocerca volvulus		0.0034	0.0648	0.5091
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0039	0.077	0.077
Onchocerca volvulus		0.0033	0.0613	0.4797
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0042	0.0823	0.0792
Trypanosoma cruzi	GUP1, putative	0.0042	0.0823	0.6429
Onchocerca volvulus		0.0034	0.0648	0.5091
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0042	0.0823	0.0823
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0648	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1601	0.1573
Brugia malayi	MBOAT family protein	0.0042	0.0823	0.1186
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0303	0.0327
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0019	0.0278	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0648	0.0616
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0042	0.0823	0.5543
Onchocerca volvulus		0.0039	0.077	0.6098
Entamoeba histolytica	hypothetical protein, conserved	0.0042	0.0823	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.073	0.073
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0042	0.0823	0.0823
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0039	0.077	0.077
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0018	0.0269	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0071	0.0056
Brugia malayi	Trypsin family protein	0.0039	0.077	0.1106
Echinococcus granulosus	dnaJ subfamily B	0.0409	0.9616	0.9616
Onchocerca volvulus		0.0039	0.077	0.6098
Echinococcus granulosus	Mastin	0.0039	0.077	0.077
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0042	0.0823	0.103
Echinococcus multilocularis	transmembrane protease serine 3	0.0039	0.077	0.077
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0062	0.0062
Schistosoma mansoni	bromodomain containing protein	0.0068	0.1454	0.1454
Schistosoma mansoni	hypothetical protein	0.0022	0.0346	0.0346
Onchocerca volvulus		0.0039	0.077	0.6098
Echinococcus granulosus	bloom syndrome protein	0.002	0.0303	0.0303
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0269	0.0353
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0071	0.0056
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0037
Schistosoma mansoni	DNA helicase recq1	0.002	0.0303	0.0303
Schistosoma mansoni	cytochrome P450	0.0018	0.0269	0.0269
Schistosoma mansoni	sterol O-acyltransferase 1	0.0425	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0071	0.0071
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0303	0.0327
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0071	0.0071
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0071	0.0309
Onchocerca volvulus		0.0014	0.0164	0.1075
Echinococcus multilocularis	enteropeptidase	0.0039	0.077	0.077
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0042	0.0823	1
Brugia malayi	steroid hormone receptor	0.001	0.0071	0.0056
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0346	0.0313
Giardia lamblia	Sgs1 DNA helicase, putative	0.002	0.0303	1
Loa Loa (eye worm)	hypothetical protein	0.0384	0.9007	0.9003
Schistosoma mansoni	hypothetical protein	0.0059	0.124	0.124
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0018	0.0269	0.3191
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0039	0.077	0.077
Brugia malayi	PHD-finger family protein	0.0028	0.0493	0.069
Brugia malayi	Trypsin family protein	0.0039	0.077	0.1106
Toxoplasma gondii	PAN domain-containing protein	0.0034	0.0648	0.0794
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0071	0.0071
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0042	0.0823	1
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.0303	0.0271
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0018	0.0269	0.3191
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0039	0.077	0.077
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0071	0.0071
Brugia malayi	PAN domain containing protein	0.0034	0.0648	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0278	0.0245
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0018	0.0269	1
Onchocerca volvulus		0.0033	0.0613	0.4797
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0037
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0018	0.0269	0.3191
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0071	0.0056
Echinococcus multilocularis	zinc finger protein	0.0022	0.0359	0.0359
Brugia malayi	Trypsin family protein	0.0039	0.077	0.1106
Schistosoma mansoni	cercarial elastase (S01 family)	0.0039	0.077	0.077
Leishmania major	cytochrome p450-like protein	0.0018	0.0269	0.0545
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0303	0.3418
Onchocerca volvulus		0.0033	0.0613	0.4797
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0272	0.0272
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0071	0.0071
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0071	0.0071
Brugia malayi	Bromodomain containing protein	0.004	0.0789	0.1135
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0042	0.0823	0.0823
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0272	0.0272
Onchocerca volvulus		0.001	0.0071	0.0309
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0042	0.0823	0.0823
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0071	0.0071
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0037
Brugia malayi	cytochrome P450	0.0018	0.0269	0.0353
Entamoeba histolytica	hypothetical protein	0.0042	0.0823	1
Onchocerca volvulus		0.0034	0.0648	0.5091
Brugia malayi	PAN domain containing protein	0.0034	0.0648	0.0924
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0064	0.1364	0.1364
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0823	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0648	0.0616
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0018	0.0269	1
Toxoplasma gondii	microneme protein MIC4	0.0034	0.0648	0.0794
Trypanosoma cruzi	cytochrome P450, putative	0.0018	0.0269	0.169
Trypanosoma brucei	glycerol uptake protein, putative	0.0042	0.0823	0.3002
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0257	0.0257
Trypanosoma cruzi	GUP1, putative	0.0042	0.0823	0.6429
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0042	0.0823	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0059	0.124	0.121
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0018	0.0269	1
Brugia malayi	diacylglycerol acyltransferase	0.0042	0.0823	0.1186
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0018	0.0269	0.3191
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0039	0.077	0.077
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0071	0.0056
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0042	0.0823	0.0823
Toxoplasma gondii	subtilisin SUB12	0.0034	0.0648	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0039	0.077	0.0738
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0433	0.0433
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0071	0.0071
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0071	0.0071
Echinococcus multilocularis	glycoprotein Antigen 5	0.0039	0.077	0.077
Leishmania major	glycerol uptake protein, putative	0.0042	0.0823	0.5937
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0071	0.0071
Echinococcus multilocularis	tissue type plasminogen activator	0.0059	0.124	0.124
Loa Loa (eye worm)	TK/ROR protein kinase	0.0059	0.124	0.121
Toxoplasma gondii	microneme protein MIC17A	0.0034	0.0648	0.0794
Brugia malayi	PAN domain containing protein	0.0034	0.0648	0.0924
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0018	0.0269	0.028
Brugia malayi	LBP/BPI	0.0014	0.0164	0.0195
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0037
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0071	0.0056
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0648	0.0616
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0071	0.0071
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0018	0.0269	0.3191
Mycobacterium leprae	putative cytochrome p450	0.0018	0.0269	0.5
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0033	0.0613	0.087
Brugia malayi	hypothetical protein	0.0287	0.6683	1
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0269	0.0353
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0042	0.0823	0.0823
Onchocerca volvulus		0.0019	0.0278	0.2026
Trypanosoma brucei	cytochrome P450, putative	0.0018	0.0269	0.0276
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0042	0.0823	0.0823
Brugia malayi	PAN domain containing protein	0.0034	0.0648	0.0924
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0071	0.0071
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0648	0.0616
Schistosoma mansoni	cercarial elastase (S01 family)	0.0039	0.077	0.077
Loa Loa (eye worm)	MBOAT family protein	0.0042	0.0823	0.0792
Entamoeba histolytica	vacuolar protein sorting 26	0.0042	0.0823	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0071	0.0071
Onchocerca volvulus		0.0033	0.0613	0.4797
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0071	0.0071
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.0269	0.0236
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0121	0.2722	0.2722
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0042	0.0823	0.103
Loa Loa (eye worm)	hhat protein	0.0042	0.0823	0.0792
Echinococcus multilocularis	bloom syndrome protein	0.002	0.0303	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0648	0.0616
Echinococcus multilocularis		0.0018	0.0269	0.0269
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.0303	0.0303
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0037
Loa Loa (eye worm)	MBOAT family protein	0.0042	0.0823	0.0792
Schistosoma mansoni	cpg binding protein	0.0032	0.0603	0.0603
Onchocerca volvulus		0.0034	0.0648	0.5091
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0018	0.0269	1
Brugia malayi	PAN domain containing protein	0.0034	0.0648	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0039	0.077	0.0738
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0039	0.077	0.077
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0018	0.0269	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0164	0.013
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0071	0.0037
Schistosoma mansoni	hypothetical protein	0.0039	0.077	0.077
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1287	0.1287
Brugia malayi	Kringle domain containing protein	0.0059	0.124	0.1814
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0034	0.0648	0.0794
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0303	0.3418
Onchocerca volvulus		0.0034	0.0648	0.5091
Brugia malayi	Protein kinase domain containing protein	0.0059	0.124	0.1814
Toxoplasma gondii	PAN domain-containing protein	0.0034	0.0648	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0278	0.0245
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0042	0.0823	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0164	0.013
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0071	0.0071
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0018	0.0269	0.169
Trypanosoma cruzi	ISWI complex protein	0.0016	0.0213	0.1211
Schistosoma mansoni	hypothetical protein	0.0409	0.9616	0.9616
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0042	0.0823	0.0823
Schistosoma mansoni	cpg binding protein	0.0032	0.0603	0.0603
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0823	1
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0034	0.0648	0.0794
Leishmania major	glycerol uptake protein, putative	0.0042	0.0823	0.5937
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0018	0.0269	0.3191
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0042	0.0823	0.6457
Onchocerca volvulus		0.0033	0.0613	0.4797
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0071	0.0071
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0042	0.0823	0.0823
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0042	0.0823	0.0823
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.0303	0.0303
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0303	0.0884
Schistosoma mansoni	cpg binding protein	0.0029	0.0516	0.0516
Schistosoma mansoni	zinc finger protein	0.0022	0.0359	0.0359
Schistosoma mansoni	cercarial elastase (S01 family)	0.0039	0.077	0.077
Schistosoma mansoni	cercarial elastase (S01 family)	0.0039	0.077	0.077
Brugia malayi	PAN domain containing protein	0.0034	0.0648	0.0924
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0018	0.0269	0.169
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0071	0.0071
Loa Loa (eye worm)	CYP4Cod1	0.0018	0.0269	0.0236
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0303	0.0405
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0042	0.0823	0.0823
Brugia malayi	hypothetical protein	0.0014	0.0164	0.0195
Onchocerca volvulus		0.0042	0.0823	0.6539
Onchocerca volvulus		0.0059	0.124	1
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0039	0.077	0.0738
Trypanosoma brucei	glycerol uptake protein, putative	0.0042	0.0823	0.3002
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0018	0.0269	1
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0018	0.0269	1
Loa Loa (eye worm)	MBOAT family protein	0.0042	0.0823	0.0792
Schistosoma mansoni	hypothetical protein	0.0016	0.0213	0.0213
Onchocerca volvulus		0.0039	0.077	0.6098
Toxoplasma gondii	hypothetical protein	0.0034	0.0648	0.0794
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.119	0.1528
Onchocerca volvulus		0.0033	0.0613	0.4797
Onchocerca volvulus		0.0034	0.0648	0.5091
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0042	0.0823	0.0823
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0033	0.0613	0.0581
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0042	0.0823	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0823	0.0792
Trypanosoma cruzi	glycerol uptake protein, putative	0.0042	0.0823	0.6429
Loa Loa (eye worm)	hypothetical protein	0.0043	0.085	0.0819
Loa Loa (eye worm)	hhat protein	0.0042	0.0823	0.0792
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0018	0.0269	0.3191
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0121	0.2722	0.2722
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0018	0.0269	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0516	0.0484
Trypanosoma cruzi	hypothetical protein, conserved	0.0059	0.124	1
Onchocerca volvulus		0.0034	0.0648	0.5091
Toxoplasma gondii	PAN domain-containing protein	0.0034	0.0648	0.0794
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0071	0.0071
Trichomonas vaginalis	DNA helicase recq1, putative	0.002	0.0303	0.3418
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0823	0.0792
Brugia malayi	nuclear hormone receptor	0.001	0.0071	0.0056
Schistosoma mansoni	cercarial elastase (S01 family)	0.0039	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0648	0.0616
Echinococcus multilocularis	cpg binding protein	0.0032	0.0603	0.0603
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.0303	0.0303
Brugia malayi	ecdysteroid receptor	0.001	0.0071	0.0056
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0018	0.0269	0.3191
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0269	0.0353
Onchocerca volvulus		0.0034	0.0648	0.5091
Leishmania major	hypothetical protein, conserved	0.0042	0.0823	0.5937
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0164	0.013
Brugia malayi	Bromodomain containing protein	0.008	0.1748	0.2577
Schistosoma mansoni	cercarial elastase (S01 family)	0.0039	0.077	0.077
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0071	0.0309
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0018	0.0269	1
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0042	0.0823	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0937	0.0906
Plasmodium falciparum	cysteine repeat modular protein 1	0.0059	0.124	1
Trypanosoma cruzi	glycerol uptake protein, putative	0.0042	0.0823	0.6429
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0071	0.0056
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0071	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.077	0.0738
Brugia malayi	MBOAT family protein	0.0042	0.0823	0.1186
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0018	0.0269	0.3191
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0039	0.077	0.1106
Echinococcus multilocularis	dnaJ subfamily B	0.0409	0.9616	0.9616
Echinococcus granulosus	transmembrane protease serine 3	0.0039	0.077	0.077
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0071	0.0012
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0039	0.077	0.077
Trichomonas vaginalis	porcupine, putative	0.0042	0.0823	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.2722	0.4043
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0071	0.0071
Echinococcus granulosus	enteropeptidase	0.0039	0.077	0.077
Echinococcus multilocularis	Mastin	0.0039	0.077	0.077
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.0269	0.0236
Toxoplasma gondii	hypothetical protein	0.0034	0.0648	0.0794
Onchocerca volvulus		0.0033	0.0613	0.4797
Echinococcus granulosus	cytochrome P450 2K1	0.0018	0.0269	0.0269
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0257	0.0257
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0018	0.0269	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0039	0.077	0.077
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0071	0.0037
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0071	0.0071
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0071	0.0037
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0018	0.0269	0.3191
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0071	0.0056
Treponema pallidum	alginate O-acetylation protein (algI)	0.0042	0.0823	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0278	0.0245
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0071	0.0071
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0019	0.0278	0.0368
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0042	0.0823	0.0823
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0042	0.0823	0.0823
Echinococcus granulosus	zinc finger protein	0.0022	0.0359	0.0359
Leishmania major	glycerol uptake protein, putative	0.0042	0.0823	0.5937
Brugia malayi	hypothetical protein	0.0019	0.0278	0.0368
Onchocerca volvulus		0.0034	0.0648	0.5091
Loa Loa (eye worm)	hypothetical protein	0.004	0.0791	0.0759
Brugia malayi	MBOAT family protein	0.0042	0.0823	0.1186
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0018	0.0269	0.169
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0164	0.013
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0071	0.0071
Leishmania major	hypothetical protein, conserved	0.0059	0.124	1
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0018	0.0269	0.3191
Onchocerca volvulus		0.0033	0.0613	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0278	0.0245
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0164	0.1644
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0018	0.0269	0.3191
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0269	0.0353
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0042	0.0042
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0018	0.0269	0.0545
Echinococcus granulosus	cpg binding protein	0.0032	0.0603	0.0603
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0071	0.0071
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0071	0.0056
Schistosoma mansoni	cercarial elastase (S01 family)	0.0039	0.077	0.077
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0018	0.0269	0.3191
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0042	0.0823	0.0823
Schistosoma mansoni	coup transcription factor	0.001	0.0071	0.0071
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0018	0.0269	0.3191
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0121	0.2722	0.2722
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0433	0.0433
Trypanosoma cruzi	cytochrome P450, putative	0.0018	0.0269	0.169
Brugia malayi	Hhat protein	0.0042	0.0823	0.1186
Schistosoma mansoni	cercarial elastase (S01 family)	0.0039	0.077	0.077
Schistosoma mansoni	cercarial elastase (S01 family)	0.0039	0.077	0.077
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0071	0.0056
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0071	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0425	1	1
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0019	0.0278	0.0245
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0303	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0039	0.077	0.0738
Toxoplasma gondii	hypothetical protein	0.0042	0.0823	0.103
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.073	0.073
Loa Loa (eye worm)	hypothetical protein	0.0039	0.077	0.0738
Brugia malayi	MBOAT family protein	0.0042	0.0823	0.1186
Loa Loa (eye worm)	hypothetical protein	0.002	0.0303	0.0271
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0071	0.0056
Toxoplasma gondii	PAN domain-containing protein	0.0319	0.745	1
Brugia malayi	Trypsin family protein	0.0039	0.077	0.1106
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0019	0.0278	0.0245
Brugia malayi	hypothetical protein	0.0019	0.0278	0.0368
Leishmania major	glycerol uptake protein, putative	0.0042	0.0823	0.5937
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0071	0.0309
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0257	0.0257
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0018	0.0269	1
Leishmania major	cytochrome p450-like protein	0.0018	0.0269	0.0545
Schistosoma mansoni	hypothetical protein	0.0042	0.0823	0.0823
Toxoplasma gondii	microneme protein MIC17C	0.0034	0.0648	0.0794
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0071	0.0056
Brugia malayi	PAN domain containing protein	0.0034	0.0648	0.0924
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0648	0.0616
Leishmania major	glycerol uptake protein, putative	0.0042	0.0823	0.5937
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.001	0.0071	0.0078
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0018	0.0269	0.3191
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0648	0.0616
Schistosoma mansoni	hypothetical protein	0.0039	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0278	0.0245
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0042	0.0042
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0018	0.0269	0.3191
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0071	0.0056
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0071	0.0071
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0071	0.0071
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0018	0.0269	1
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0033	0.0613	0.087
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0037
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0037
Toxoplasma gondii	microneme protein MIC17B	0.0034	0.0648	0.0794
Brugia malayi	MBOAT family protein	0.0042	0.0823	0.1186
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0272	0.0272
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0648	0.0616
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.2722	0.2697
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0613	0.0581
Brugia malayi	PAN domain containing protein	0.0034	0.0648	0.0924
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0071	0.0056
Trypanosoma cruzi	glycerol uptake protein, putative	0.0042	0.0823	0.6429
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0071	0.0037
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.0303	0.0303
Loa Loa (eye worm)	RecQ helicase	0.002	0.0303	0.0271
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0018	0.0269	0.3191
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0071	0.0071
Echinococcus granulosus	tissue type plasminogen activator	0.0059	0.124	0.124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0071	0.0037
Loa Loa (eye worm)	cytochrome P450	0.0018	0.0269	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0648	0.0616
Toxoplasma gondii	microneme protein, putative	0.0034	0.0648	0.0794
Schistosoma mansoni	DNA helicase recq5	0.002	0.0303	0.0303
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0071	0.0071
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0018	0.0269	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0039	0.077	0.077
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0039	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0039	0.077	0.0738
Entamoeba histolytica	recQ family DNA helicase	0.001	0.0071	0.0121
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0071	0.0037
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0019	0.0278	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0121	0.2731	0.2706
Toxoplasma gondii	PAN domain-containing protein	0.0319	0.745	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0272	0.0238
Toxoplasma gondii	PAN domain-containing protein	0.0034	0.0648	0.0794
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.0269	0.0236
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0018	0.0269	1
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0018	0.0269	0.0276
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0087	0.008
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0071	0.0071
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0433	0.0433
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0033	0.0613	0.087
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0018	0.0269	0.3191
Schistosoma mansoni	hypothetical protein	0.0101	0.2245	0.2245
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0071	0.0071
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0042	0.0823	0.0823
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0042	0.0823	0.0823
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0018	0.0269	0.3191
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0648	0.0616
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0018	0.0269	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0071	0.0056
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0018	0.0269	0.3191
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0042	0.0008
Leishmania major	cytochrome p450-like protein	0.0018	0.0269	0.0545
Brugia malayi	Trypsin-like protease protein 5	0.0039	0.077	0.1106
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0121	0.2722	0.2722
Schistosoma mansoni	cercarial elastase (S01 family)	0.0039	0.077	0.077
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0039	0.077	0.077
Schistosoma mansoni	zinc finger protein	0.0042	0.0823	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0823	0.0792
Brugia malayi	hypothetical protein	0.0039	0.077	0.1106
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0059	0.124	1
Trypanosoma cruzi	ISWI complex protein	0.0016	0.0213	0.1211
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0042	0.0823	1
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0018	0.0269	0.3191

Activities

Activity type	Activity value	Assay description	Source	Reference
ID50 (functional)	= 1.4 mg kg-1	Antiinflammatory activity on peroral administration against carrageenan paw edema	ChEMBL.	6607354
ID50 (functional)	= 3.6 mg kg-1	Analgesic activity on peroral administration against Scald induced pain in rat paw	ChEMBL.	6607354

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL68662
PubChem: 21312278

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 111668