Detailed information for compound 1120109

Basic information

Technical information
  • TDR Targets ID: 1120109
  • Name: 2-[5-[2-[(4-ethoxyphenyl)amino]-2-oxoethyl]su lfanyl-3-oxo-2H-imidazo[1,2-c]quinazolin-2-yl ]-N-[(2-methoxyphenyl)methyl]acetamide
  • MW: 571.647 | Formula: C30H29N5O5S
  • H donors: 2 H acceptors: 3 LogP: 3.47 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOc1ccc(cc1)NC(=O)CSc1nc2ccccc2c2=NC(C(=O)n12)CC(=O)NCc1ccccc1OC
  • InChi: 1S/C30H29N5O5S/c1-3-40-21-14-12-20(13-15-21)32-27(37)18-41-30-34-23-10-6-5-9-22(23)28-33-24(29(38)35(28)30)16-26(36)31-17-19-8-4-7-11-25(19)39-2/h4-15,24H,3,16-18H2,1-2H3,(H,31,36)(H,32,37)
  • InChiKey: TVAAUBHZQIVDOT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[5-[2-[(4-ethoxyphenyl)amino]-2-oxo-ethyl]sulfanyl-3-oxo-2H-imidazo[1,2-c]quinazolin-2-yl]-N-[(2-methoxyphenyl)methyl]acetamide
  • 2-[5-[[2-[(4-ethoxyphenyl)amino]-2-oxoethyl]thio]-3-oxo-2H-imidazo[1,2-c]quinazolin-2-yl]-N-[(2-methoxyphenyl)methyl]acetamide
  • 2-[5-[[2-[(4-ethoxyphenyl)amino]-2-keto-ethyl]thio]-3-keto-2H-imidazo[1,2-c]quinazolin-2-yl]-N-(2-methoxybenzyl)acetamide
  • 2-[5-[2-[(4-ethoxyphenyl)amino]-2-oxo-ethyl]sulfanyl-3-oxo-2H-imidazo[1,2-c]quinazolin-2-yl]-N-[(2-methoxyphenyl)methyl]ethanamide
  • K279-1410
  • NCGC00138534-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0012 0.0096 0.0307
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.1093 0.1093
Schistosoma mansoni hypothetical protein 0.0019 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0021 0.0315 0.037
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0396 0.1261
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.1132 0.1333
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0457 0.2546
Brugia malayi tailless protein 0.002 0.0296 0.0761
Echinococcus granulosus cpg binding protein 0.003 0.0554 0.0554
Leishmania major DNA polymerase eta, putative 0.0051 0.1066 0.3395
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0296 0.0296
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0012 0.0096 0.0307
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0119 0.2793 0.2793
Toxoplasma gondii Alpha-galactosidase 0.0017 0.022 0.0702
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.1093 0.1093
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0396 0.2471
Brugia malayi steroid hormone receptor 0.0042 0.0856 0.2199
Loa Loa (eye worm) hypothetical protein 0.0022 0.0356 0.0419
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0856 0.0856
Echinococcus multilocularis lamin 0.0029 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0856 0.0856
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0259 0.1618
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0218 0.1362
Trypanosoma brucei unspecified product 0.0015 0.0174 0.1084
Echinococcus granulosus smad 0.0009 0.0034 0.0034
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.049 0.156
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0856 0.2199
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0344 0.2144
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0034 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0012 0.0096 0.0302
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.049 0.1539
Toxoplasma gondii NAC domain-containing protein 0.0072 0.1602 0.5103
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0856 0.7139
Echinococcus multilocularis geminin 0.0191 0.4601 0.4601
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0286 0.0899
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0218 0.1362
Echinococcus multilocularis snurportin 1 0.0346 0.8493 0.8493
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0012 0.0096 0.0302
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0856 0.0856
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0012 0.0096 0.0302
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0856 0.2199
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.1001 0.6244
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0259 0.1445
Loa Loa (eye worm) hypothetical protein 0.0021 0.0315 0.037
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0396 0.0396
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.3184 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.049 0.156
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0344 0.2146
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.3184 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0296 0.0296
Brugia malayi RNA, U transporter 1 0.0092 0.2113 0.543
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.1199 0.1199
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0396 0.2471
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0259 0.0259
Schistosoma mansoni smad 0.0009 0.0034 0.0034
Plasmodium falciparum basic transcription factor 3b, putative 0.0072 0.1602 1
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0344 0.0883
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0012 0.0096 0.0307
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0856 0.0856
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0012 0.0096 0.0307
Leishmania major cytochrome p450-like protein 0.0012 0.0096 0.0307
Loa Loa (eye worm) hypothetical protein 0.0042 0.0856 0.1008
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.049 0.156
Plasmodium vivax basic transcription factor 3b, putative 0.0072 0.1602 1
Schistosoma mansoni hypothetical protein 0.0019 0.0275 0.0275
Onchocerca volvulus 0.0056 0.1199 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.2724 0.2724
Plasmodium falciparum thioredoxin reductase 0.0018 0.0259 0.1618
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0119 0.2793 0.2793
Brugia malayi MH1 domain containing protein 0.0009 0.0034 0.0088
Plasmodium falciparum importin beta, putative 0.0032 0.0611 0.3813
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0259 0.0826
Echinococcus granulosus snurportin 1 0.0346 0.8493 0.8493
Schistosoma mansoni Smad4 0.0009 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0296 0.247
Echinococcus multilocularis GPCR, family 2 0.0019 0.0275 0.0275
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0012 0.0096 0.0302
Onchocerca volvulus 0.002 0.0296 0.247
Loa Loa (eye worm) hypothetical protein 0.0029 0.0517 0.0608
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0218 0.1362
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0296 0.0349
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0012 0.0096 0.0307
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0259 0.0666
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.2724 0.2724
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0517 0.0608
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0259 0.0826
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0856 0.1008
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0296 0.247
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.1132 0.7066
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0611 0.1946
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0856 0.0856
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0513 0.0604
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.008 0.1795 0.1795
Echinococcus multilocularis tumor protein p63 0.0381 0.9378 0.9378
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0163 0.3891 0.3891
Schistosoma mansoni lipoxygenase 0.0081 0.1843 0.1843
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0259 0.0826
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0296 0.0296
Onchocerca volvulus 0.0029 0.0513 0.4277
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0856 0.1008
Brugia malayi beta-NAC-like protein 0.0072 0.1602 0.4118
Schistosoma mansoni hypothetical protein 0.0012 0.0096 0.0096
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0296 0.0296
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0259 0.1618
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.314 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0182 0.0215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.1093 0.1093
Giardia lamblia DINP protein human, muc B family 0.0022 0.0344 0.1316
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0286 0.0286
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.1001 0.1001
Brugia malayi AMP-binding enzyme family protein 0.0028 0.049 0.1259
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0144 0.0144
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0315 0.0988
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0856 0.0856
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0012 0.0096 0.0302
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0457 0.2546
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.314 0.314
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0517 0.0608
Brugia malayi hypothetical protein 0.0022 0.0356 0.0915
Schistosoma mansoni hypothetical protein 0.0041 0.083 0.083
Loa Loa (eye worm) hypothetical protein 0.0022 0.0356 0.0419
Brugia malayi MH1 domain containing protein 0.0009 0.0034 0.0088
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.8493 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.049 0.3058
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0689 0.4297
Loa Loa (eye worm) hypothetical protein 0.0056 0.1199 0.1412
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0259 0.0814
Loa Loa (eye worm) hypothetical protein 0.0042 0.0856 0.1008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.1093 0.1287
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0259 0.1618
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0344 0.0405
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0296 0.0296
Schistosoma mansoni hypothetical protein 0.0019 0.0286 0.0286
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0259 0.1618
Onchocerca volvulus 0.002 0.0296 0.247
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.1132 0.3556
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0286 0.0286
Echinococcus granulosus RUN 0.0019 0.0286 0.0286
Brugia malayi intermediate filament protein 0.0029 0.0517 0.1328
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0611 0.0611
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0034 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.049 0.156
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0259 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0856 0.1008
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0218 0.0695
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0259 0.1618
Brugia malayi nuclear hormone receptor 0.002 0.0296 0.0761
Loa Loa (eye worm) hypothetical protein 0.0028 0.049 0.0577
Entamoeba histolytica Ran family GTPase 0.0024 0.0396 0.2471
Onchocerca volvulus 0.0019 0.0286 0.2383
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0296 0.0349
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0856 0.0856
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0856 0.2199
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0344 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0856 0.1008
Leishmania major GTP-binding protein, putative 0.0024 0.0396 0.1261
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0856 0.2199
Echinococcus granulosus tumor protein p63 0.0381 0.9378 0.9378
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0286 0.0899
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0856 0.2199
Loa Loa (eye worm) hypothetical protein 0.0042 0.0856 0.1008
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Toxoplasma gondii thioredoxin reductase 0.0053 0.1132 0.3606
Schistosoma mansoni hypothetical protein 0.0346 0.8493 0.8493
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0296 0.0761
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1309 0.1541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0856 0.1008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0259 0.1618
Brugia malayi hypothetical protein 0.0019 0.0286 0.0734
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Onchocerca volvulus 0.0042 0.0856 0.7139
Brugia malayi cytochrome P450 0.0012 0.0096 0.0247
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0012 0.0096 0.0302
Loa Loa (eye worm) hypothetical protein 0.006 0.1309 0.1541
Loa Loa (eye worm) hypothetical protein 0.0019 0.0286 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0856 0.2199
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0012 0.0096 0.0307
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0856 0.7139
Loa Loa (eye worm) hypothetical protein 0.0028 0.049 0.0577
Plasmodium vivax importin-beta 2, putative 0.0032 0.0611 0.3813
Brugia malayi Doublecortin family protein 0.0019 0.0286 0.0734
Brugia malayi glutathione reductase 0.0053 0.1132 0.291
Mycobacterium leprae Conserved hypothetical protein 0.0012 0.0096 0.0302
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0218 0.0695
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.2844 0.8932
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.1132 0.1132
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0856 0.0856
Loa Loa (eye worm) acetyltransferase 0.0163 0.3891 0.4582
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0012 0.0096 0.0307
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0856 0.0856
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0286 0.0336
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0856 0.0856
Brugia malayi Melibiase family protein 0.008 0.1795 0.4612
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0012 0.0096 0.0307
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0012 0.0096 0.0307
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0856 0.1008
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0344 0.0344
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.2844 0.8932
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0012 0.0096 0.0307
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.1093 0.1093
Toxoplasma gondii cytochrome p450 superfamily protein 0.0012 0.0096 0.0307
Schistosoma mansoni cytochrome P450 0.0012 0.0096 0.0096
Echinococcus granulosus GPCR family 2 0.0019 0.0275 0.0275
Loa Loa (eye worm) Smad1 0.0009 0.0034 0.004
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0119 0.2793 0.2793
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0012 0.0096 0.0307
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0396 0.2471
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0296 0.0296
Trypanosoma brucei unspecified product 0.0015 0.0174 0.1084
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0275 0.0324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0856 0.1008
Trypanosoma cruzi transcription factor btf3, putative 0.0072 0.1602 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0144 0.0144
Echinococcus multilocularis musashi 0.0029 0.0517 0.0517
Schistosoma mansoni nuclear hormone receptor 0.002 0.0296 0.0296
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0259 0.1618
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0191 0.4601 0.4601
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.083 0.2133
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0856 0.0856
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0012 0.0096 0.0302
Echinococcus multilocularis smad 0.0009 0.0034 0.0034
Schistosoma mansoni lamin 0.0029 0.0517 0.0517
Schistosoma mansoni rab6-interacting 0.0019 0.0286 0.0286
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.049 0.156
Trypanosoma brucei trypanothione reductase 0.0053 0.1132 0.7066
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.2844 0.8932
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0856 0.0856
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0856 0.0856
Mycobacterium tuberculosis Probable reductase 0.0121 0.2844 0.8932
Brugia malayi nuclear receptor NHR-67 0.002 0.0296 0.0761
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0286 0.1783
Schistosoma mansoni lipoxygenase 0.0117 0.2724 0.2724
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0611 0.3813
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0856 0.2199
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0182 0.0468
Mycobacterium leprae putative cytochrome p450 0.0012 0.0096 0.0302
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0856 0.0856
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0034 0.0034
Leishmania major importin beta-1 subunit, putative 0.0026 0.0457 0.1455
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0344 0.0405
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0259 0.1618
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0344 0.1095
Trichomonas vaginalis ran, putative 0.0024 0.0396 0.2206
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0296 0.0349
Schistosoma mansoni loxhd1 0.0019 0.0286 0.0286
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.049 0.1539
Entamoeba histolytica hypothetical protein 0.0026 0.0457 0.2852
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0611 0.3813
Schistosoma mansoni smad1 5 8 and 0.0009 0.0034 0.0034
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0344 0.2144
Treponema pallidum NADH oxidase 0.0018 0.0259 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0344 0.0405
Echinococcus multilocularis RUN 0.0019 0.0286 0.0286
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.314 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0856 0.0856
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0856 0.2199
Echinococcus granulosus intermediate filament protein 0.0029 0.0517 0.0517
Brugia malayi MH2 domain containing protein 0.0009 0.0034 0.0088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.049 0.1539
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1316 0.1316
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.1132 0.1132
Leishmania major cytochrome p450-like protein 0.0022 0.0344 0.1095
Brugia malayi nuclear receptor NHR-88 0.0042 0.0856 0.2199
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0119 0.2793 0.2793
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0457 0.2852
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0259 0.1618
Brugia malayi Cytochrome P450 family protein 0.0012 0.0096 0.0247
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0012 0.0096 0.0302
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0259 0.1618
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0296 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0022 0.0356 0.0419
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0012 0.0096 0.0302
Echinococcus multilocularis cpg binding protein 0.003 0.0554 0.0554
Schistosoma mansoni hypothetical protein 0.0019 0.0275 0.0275
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0296 0.0296
Echinococcus multilocularis transcription factor btf3 0.0072 0.1602 0.1602
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0012 0.0096 0.0302
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0856 0.0856
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0012 0.0096 0.0302
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0517 0.1328
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0856 0.2199
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0296 0.0761
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.049 0.3058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0356 0.0419
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0218 0.0218
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0259 0.1618
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0012 0.0096 0.0307
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Plasmodium falciparum thioredoxin reductase 0.0053 0.1132 0.7066
Leishmania major DNA polymerase eta, putative 0.0036 0.0689 0.2193
Loa Loa (eye worm) ICD-1 protein 0.0072 0.1602 0.1887
Leishmania major DNA polymerase kappa, putative 0.0022 0.0344 0.1094
Loa Loa (eye worm) hypothetical protein 0.0051 0.1066 0.1255
Plasmodium falciparum glutathione reductase 0.0053 0.1132 0.7066
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0856 0.2199
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.1602 0.8928
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.1001 0.5575
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.314 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0131 0.0154
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0017 0.022 0.022
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0096 0.0601
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0344 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0856 0.2199
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0259 0.1618
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0689 0.2193
Schistosoma mansoni ran 0.0024 0.0396 0.0396
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0012 0.0096 0.0302
Schistosoma mansoni ran 0.0024 0.0396 0.0396
Schistosoma mansoni nuclear hormone receptor 0.002 0.0296 0.0296
Mycobacterium ulcerans hypothetical protein 0.0028 0.049 0.156
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0344 0.1915
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0356 0.0915
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0396 0.0396
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0315 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0296 0.0296
Schistosoma mansoni rab6-interacting 0.0019 0.0286 0.0286
Plasmodium falciparum glutathione reductase 0.0018 0.0259 0.1618
Trypanosoma brucei transcription factor BTF3, putative 0.0072 0.1602 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.0517 0.0517
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.008 0.1795 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0018 0.0018
Brugia malayi conserved hypotetical protein 0.002 0.0296 0.0761
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0356 0.0915
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0856 0.0856
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0344 0.1094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0286 0.0899
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0012 0.0096 0.0601
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0356 0.0356
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0356 0.0419
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0356 0.0356
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0034 0.004
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0296 0.0761
Brugia malayi CXXC zinc finger family protein 0.0029 0.0513 0.1318
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.3184 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.049 0.3058
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0136 0.0351
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0344 0.1079
Schistosoma mansoni transcription factor btf3 0.0072 0.1602 0.1602
Brugia malayi nuclear receptor NHR-88 0.002 0.0296 0.0761
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0012 0.0096 0.0307
Brugia malayi Thioredoxin reductase 0.0053 0.1132 0.291
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0856 0.0856
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.09 0.5618
Onchocerca volvulus 0.0019 0.0286 0.2383
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0275 0.0706
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0296 0.0296
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0259 0.1618
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0344 0.1079
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0286 0.0286
Brugia malayi AMP-binding enzyme family protein 0.0028 0.049 0.1259
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0021 0.0315 0.037
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0096 0.0601
Trypanosoma brucei unspecified product 0.0022 0.0344 0.2144
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1254 0.3994
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0018 0.0021
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0344 0.2146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0259 0.1618
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0344 0.0405
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.1132 0.7066
Brugia malayi nuclear receptor RXR 0.002 0.0296 0.0761
Onchocerca volvulus 0.0029 0.0517 0.4309
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0259 0.0826
Loa Loa (eye worm) hypothetical protein 0.0042 0.0856 0.1008
Brugia malayi Cytochrome P450 family protein 0.0022 0.0344 0.0884
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0012 0.0096 0.0307
Schistosoma mansoni DNA polymerase eta 0.0051 0.1066 0.1066
Loa Loa (eye worm) hypothetical protein 0.0042 0.0856 0.1008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.314 1
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0344 0.1094
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0296 0.0296
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0218 0.0218
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0012 0.0096 0.0307
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.3776 0.3776
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0096 0.0096
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0275 0.0275
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0296 0.0296
Echinococcus multilocularis Smad4 0.0009 0.0034 0.0034
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0344 0.1915
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0457 0.2546
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.008 0.1795 0.2113
Brugia malayi Nuclear hormone receptor E75 0.002 0.0296 0.0761
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0259 0.0826
Echinococcus granulosus lamin 0.0029 0.0517 0.0517
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0034 0.0034
Schistosoma mansoni zinc finger protein 0.002 0.0296 0.0296
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.314 0.9862
Loa Loa (eye worm) hypothetical protein 0.0028 0.0503 0.0593
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.1602 0.8928
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0344 0.1094
Leishmania major cytochrome p450-like protein 0.0012 0.0096 0.0307
Schistosoma mansoni smad1 5 8 and 0.0009 0.0034 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.049 0.156
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0259 0.1618
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0344 0.2146
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0218 0.1362
Trypanosoma cruzi transcription factor btf3, putative 0.0072 0.1602 1
Toxoplasma gondii melibiase subfamily protein 0.0119 0.2793 0.8895
Echinococcus multilocularis lamin dm0 0.0029 0.0517 0.0517
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0012 0.0096 0.0302
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0344 0.2144
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.049 0.156
Brugia malayi AMP-binding enzyme family protein 0.0028 0.049 0.1259
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0218 0.0686
Brugia malayi ecdysone receptor 0.002 0.0296 0.0761
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0396 0.2471
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0856 0.0856
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.3289 0.3873
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.1174 0.1383
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0136 0.0351
Brugia malayi Cytochrome P450 family protein 0.0055 0.1174 0.3018
Echinococcus granulosus Smad4 0.0009 0.0034 0.0034
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0356 0.0356
Brugia malayi isocitrate dehydrogenase 0.0017 0.0218 0.0561
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0856 0.0856
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.1066 0.6652
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0856 0.2199
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0012 0.0096 0.0307
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.049 0.156
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0396 0.2132
Schistosoma mansoni nuclear receptor 0.002 0.0296 0.0296
Schistosoma mansoni hypothetical protein 0.0019 0.0275 0.0275
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0315 0.1964
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0259 0.1445
Brugia malayi Importin beta-1 subunit 0.0032 0.0611 0.157
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0259 0.1618
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0218 0.0218
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0856 0.0856
Echinococcus multilocularis 0.0012 0.0096 0.0096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0275 0.0275
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.2844 0.8932
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0218 0.0695
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0218 0.1362
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0286 0.0899
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0012 0.0096 0.0302
Schistosoma mansoni lamin 0.0029 0.0517 0.0517
Plasmodium vivax glutathione reductase, putative 0.0053 0.1132 0.7066
Schistosoma mansoni importin beta-1 0.0032 0.0611 0.0611
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0012 0.0096 0.0307
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.314 0.314
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0856 0.0856
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0856 0.2199
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0856 0.0856
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0856 0.0856
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0012 0.0096 0.0302
Entamoeba histolytica transcription factor BTF3, putative 0.0072 0.1602 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1309 0.3363
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0296 0.0296
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0856 0.0856
Brugia malayi hypothetical protein 0.002 0.0296 0.0761
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0169
Brugia malayi hypothetical protein 0.002 0.0296 0.0761
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.3184 1
Brugia malayi MH2 domain containing protein 0.0139 0.3289 0.8453
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.008 0.1795 0.1795
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1309 0.3363
Schistosoma mansoni cpg binding protein 0.003 0.0554 0.0554
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0856 0.0856
Schistosoma mansoni smad1 5 8 and 0.0009 0.0034 0.0034
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0218 0.0218
Brugia malayi acetyltransferase, GNAT family protein 0.0163 0.3891 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0218 0.0218
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0259 0.0259
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0019 0.0286 0.0336
Brugia malayi hypothetical protein 0.0022 0.0356 0.0915
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0856 0.1008
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0015 0.0039
Echinococcus granulosus lamin dm0 0.0029 0.0517 0.0517
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0856 0.2199
Loa Loa (eye worm) hypothetical protein 0.0021 0.0315 0.037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.314 1
Schistosoma mansoni hypothetical protein 0.0191 0.4601 0.4601
Brugia malayi nuclear receptor RXR 0.0022 0.0356 0.0915
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0174 0.1084
Loa Loa (eye worm) DR-78 0.002 0.0296 0.0349
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0034 0.0034
Echinococcus granulosus dna polymerase eta 0.0051 0.1066 0.1066
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0856 0.0856
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0119 0.2793 0.2793
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0259 0.0826
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Schistosoma mansoni coup transcription factor 0.0042 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0028 0.049 0.0577
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0396 0.0466
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0856 0.7139
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0259 0.0826
Entamoeba histolytica hypothetical protein 0.0072 0.1602 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.1093 0.281
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0012 0.0096 0.0307
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Loa Loa (eye worm) hypothetical protein 0.0042 0.0856 0.1008
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.049 0.156
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.049 0.1539
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0021 0.0315 0.037
Brugia malayi Smad1 0.0009 0.0034 0.0088
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0296 0.0296
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.2844 0.8932
Loa Loa (eye worm) cytochrome P450 0.0012 0.0096 0.0113
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0315 0.1964
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0856 0.2199
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.314 0.314
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.09 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0611 0.0719
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0286 0.0286
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0296 0.0296
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0315 0.1002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.1093 0.1093
Brugia malayi nuclear hormone receptor 0.0042 0.0856 0.2199
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0052
Echinococcus granulosus importin subunit beta 1 0.0032 0.0611 0.0611
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.049 0.156
Schistosoma mansoni cpg binding protein 0.003 0.0554 0.0554
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0275 0.0706
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0259 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.0856 0.1008
Brugia malayi Nuclear hormone receptor E75 0.002 0.0296 0.0761
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0012 0.0096 0.0307
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0396 0.2471
Schistosoma mansoni hypothetical protein 0.0406 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.1602 0.8928
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0012 0.0096 0.0302
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.1001 0.3187
Brugia malayi hypothetical protein 0.0019 0.0286 0.0734
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0218 0.1362
Echinococcus granulosus geminin 0.0191 0.4601 0.4601
Loa Loa (eye worm) hypothetical protein 0.0042 0.0856 0.1008
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0259 0.1618
Loa Loa (eye worm) hypothetical protein 0.0013 0.0131 0.0154
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0012 0.0096 0.0302
Loa Loa (eye worm) hypothetical protein 0.0022 0.0356 0.0419
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0344 0.2144
Schistosoma mansoni cpg binding protein 0.0029 0.0513 0.0513
Schistosoma mansoni nuclear receptor 0.002 0.0296 0.0296
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0344 0.0344
Leishmania major trypanothione reductase 0.0053 0.1132 0.3606
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0218 0.0218
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0259 0.0826
Loa Loa (eye worm) hypothetical protein 0.0019 0.0275 0.0324
Leishmania major basic transcription factor 3a, putative 0.0072 0.1602 0.5103
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0218 0.0561
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0286 0.0286
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0286 0.0286
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0396 0.1017
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0119 0.2793 0.2793
Echinococcus multilocularis dna polymerase eta 0.0051 0.1066 0.1066
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0344 0.0344
Brugia malayi ecdysteroid receptor 0.0042 0.0856 0.2199
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Onchocerca volvulus 0.0028 0.049 0.4087
Loa Loa (eye worm) hypothetical protein 0.0041 0.083 0.0977
Trypanosoma brucei DNA polymerase eta, putative 0.0051 0.1066 0.6652
Echinococcus multilocularis dnaJ subfamily B 0.0406 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.1093 0.1093
Loa Loa (eye worm) glutathione reductase 0.0053 0.1132 0.1333
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0174 0.1084
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.1001 0.3187
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.1001 0.5575
Schistosoma mansoni polycystin 1-related 0.0019 0.0286 0.0286
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0356 0.0356
Brugia malayi ImpB/MucB/SamB family protein 0.0051 0.1066 0.2739
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0344 0.2144
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0012 0.0096 0.0302
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0856 0.2199
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0218 0.0257
Brugia malayi Cytochrome P450 family protein 0.0022 0.0344 0.0884
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0012 0.0096 0.0302
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.3289 0.3873
Echinococcus granulosus dna polymerase kappa 0.0022 0.0344 0.0344
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.09 0.5618
Echinococcus granulosus transcription factor btf3 0.0072 0.1602 0.1602
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0012 0.0096 0.0307
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0856 0.0856
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0119 0.2793 0.2793
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0012 0.0096 0.0307
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.314 0.314
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0259 0.0826
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0012 0.0096 0.0601
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0275 0.0275
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0163 0.3891 0.3891
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Onchocerca volvulus 0.0029 0.0517 0.4309
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0012 0.0096 0.0302
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0286 0.1783
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.002 0.0296 0.0349
Brugia malayi MH2 domain containing protein 0.0009 0.0034 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0174 0.1084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.1093 0.1093
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.2844 0.8932

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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