Detailed information for compound 1182096

Basic information

Technical information
  • TDR Targets ID: 1182096
  • Name: 2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1 ,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
  • MW: 275.282 | Formula: C13H14FN5O
  • H donors: 3 H acceptors: 3 LogP: 0.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: FCCC1CNC(=O)c2c1[nH]c(c2)c1ccnc(n1)N
  • InChi: 1S/C13H14FN5O/c14-3-1-7-6-17-12(20)8-5-10(18-11(7)8)9-2-4-16-13(15)19-9/h2,4-5,7,18H,1,3,6H2,(H,17,20)(H2,15,16,19)
  • InChiKey: LCBAQTCTQXHTJG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-amino-4-pyrimidinyl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cell division cycle 7 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus multilocularis CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129189 All targets in OG5_129189
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Loa Loa (eye worm) CDC7 protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Giardia lamblia Kinase, CDC7 Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum ko:K02214 cell division control protein CDC7, putative Get druggable targets OG5_129189 All targets in OG5_129189
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0021 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0434 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0496 0.1344
Schistosoma mansoni hypothetical protein 0.013 0.1337 0.151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0008 0.001
Echinococcus granulosus Protein kinase C brain isozyme 0.009 0.0854 0.0965
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0072 0.0631 0.3625
Echinococcus granulosus raf serine:threonine protein kinase 0.002 0.0002 0.0002
Toxoplasma gondii AGC kinase 0.0058 0.0466 0.3922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0103 0.1011 0.5808
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Schistosoma mansoni tyrosine kinase 0.0025 0.0056 0.0062
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0072 0.0631 0.3625
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0125 0.1276 0.1443
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.1384 0.1563
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0414 0.1373
Echinococcus granulosus protein kinase C gamma type 0.0083 0.0764 0.0864
Schistosoma mansoni plexin 0.0021 0.0007 0.0006
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0059 0.0473 0.2716
Echinococcus multilocularis mitogen activated protein kinase 14 0.0162 0.1739 0.1739
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.011 0.011
Loa Loa (eye worm) latrophilin receptor protein 2 0.006 0.0486 0.0727
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0027 0.0148
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0103 0.1011 0.5808
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0452 0.1509
Brugia malayi Fibronectin type III domain containing protein 0.0033 0.0153 0.0227
Echinococcus multilocularis tyrosine protein kinase ABL1 0.027 0.306 0.306
Echinococcus multilocularis c src tyrosine kinase 0.0029 0.011 0.011
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0236 0.0236
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0027 0.0148
Plasmodium falciparum serine/threonine protein kinase, putative 0.0078 0.0712 0.5139
Loa Loa (eye worm) CAMK/CAMKL/NIM1 protein kinase 0.011 0.1097 0.1641
Echinococcus multilocularis aurora kinase A 0.0078 0.0712 0.0712
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0103 0.1011 0.1141
Echinococcus multilocularis serine threonine protein kinase 0.0133 0.1384 0.1384
Echinococcus multilocularis protein kinase c epsilon type 0.0042 0.0271 0.0271
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Echinococcus granulosus protein kinase shaggy 0.0068 0.0588 0.0665
Onchocerca volvulus 0.0566 0.6682 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0473 0.0534
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2575 0.6991
Echinococcus multilocularis serine threonine protein kinase 0.0083 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0077 0.0689 0.1031
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.2351 0.2656
Schistosoma mansoni atypical protein kinase C 0.0041 0.0253 0.0284
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0236 0.0351
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0065 0.0548 0.082
Loa Loa (eye worm) hypothetical protein 0.0048 0.0335 0.0501
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.3533 0.3533
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0236 0.0267
Brugia malayi Cytochrome P450 family protein 0.005 0.0368 0.0549
Giardia lamblia Kinase, CMGC GSK 0.0068 0.0588 0.1594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.059 0.16
Schistosoma mansoni tyrosine kinase 0.0029 0.011 0.0123
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0689 0.103
Loa Loa (eye worm) transcription factor SMAD2 0.0231 0.2577 0.3857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Schistosoma mansoni hypothetical protein 0.0087 0.0814 0.0919
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0414 0.1373
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.0689 0.1868
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0124 0.0184
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0008 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0008 0.0002
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0034 0.0163 0.0185
Echinococcus granulosus nervana 2 0.0025 0.0055 0.0062
Loa Loa (eye worm) hypothetical protein 0.009 0.0854 0.1278
Brugia malayi glutaminase DH11.1 0.0255 0.2874 0.4301
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0228 0.2539 0.287
Brugia malayi Protein kinase domain containing protein 0.017 0.1831 0.2739
Schistosoma mansoni cell adhesion molecule 0.0037 0.0209 0.0235
Brugia malayi serine/threonine-protein kinase PAK 7 0.0231 0.258 0.386
Echinococcus multilocularis expressed conserved protein 0.0197 0.2164 0.2164
Echinococcus granulosus fibroblast growth factor receptor 4 0.0132 0.1369 0.1547
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0008 0.0009
Echinococcus granulosus serine:threonine protein kinase NIM1 0.011 0.1097 0.124
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0068 0.0588 0.088
Echinococcus multilocularis cyclin dependent kinase 0.0114 0.1146 0.1146
Brugia malayi hypothetical protein 0.0034 0.0168 0.025
Loa Loa (eye worm) hypothetical protein 0.0148 0.1562 0.2338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1583 0.1788
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0021 0.0012 0.0014
Echinococcus multilocularis protein patched 0.009 0.0854 0.0854
Schistosoma mansoni serine/threonine kinase 0.0034 0.0163 0.0183
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0162 0.1739 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0087 0.0087
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.006 0.0486 0.0727
Loa Loa (eye worm) TK/ALK protein kinase 0.0297 0.3387 0.5069
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0321 0.3682 1
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0279 0.0755
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0712 0.193
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.1146 0.1146
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0027 0.0031
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0008 0.001
Schistosoma mansoni hypothetical protein 0.0743 0.8846 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0027 0.0148
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0046 0.0254
Entamoeba histolytica protein kinase 2, putative 0.0036 0.0188 0.0507
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Loa Loa (eye worm) phosphatidylinositol 3 0.0103 0.1011 0.1512
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0068 0.0588 0.3378
Echinococcus multilocularis serine:threonine protein kinase 38 0.0034 0.0163 0.0163
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0144 0.151 0.1707
Echinococcus granulosus Protein patched homolog 1 0.009 0.0854 0.0965
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Loa Loa (eye worm) hypothetical protein 0.0141 0.1478 0.2212
Loa Loa (eye worm) hypothetical protein 0.0059 0.0473 0.0708
Echinococcus granulosus protein kinase c epsilon type 0.0042 0.0271 0.0306
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0036 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0309 0.3533 0.5287
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0008 0.001
Schistosoma mansoni serine/threonine protein kinase 0.011 0.1097 0.1238
Brugia malayi steroid hormone receptor 0.0021 0.0008 0.001
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0029 0.011 0.0124
Entamoeba histolytica hypothetical protein 0.0067 0.0576 0.156
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0087 0.0814 0.0919
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.1146 0.659
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0588 0.1594
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0072 0.0631 0.3625
Leishmania major protein kinase A catalytic subunit 0.0059 0.0473 0.2716
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0132 0.1369 0.1547
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0008 0.0012
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0452 0.1493
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0025 0.0055 0.0055
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0133 0.1384 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0496 0.1344
Brugia malayi hypothetical protein 0.0148 0.1562 0.2336
Schistosoma mansoni pyruvate dehydrogenase 0.0144 0.151 0.1706
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0153 0.0227
Onchocerca volvulus 0.0027 0.008 0.0109
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.006 0.0486 0.0725
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.0252
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0689 0.3959
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0029 0.011 0.011
Schistosoma mansoni tyrosine kinase 0.0029 0.011 0.0123
Brugia malayi Immunoglobulin I-set domain containing protein 0.0259 0.2918 0.4366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Echinococcus granulosus mitogen activated protein kinase 11 0.0162 0.1739 0.1966
Brugia malayi Protein kinase domain containing protein 0.0203 0.2234 0.3342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0537 0.1456
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.1583 0.1789
Loa Loa (eye worm) hypothetical protein 0.0103 0.1013 0.1516
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0029 0.011 0.011
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0588 0.1594
Loa Loa (eye worm) plexin A 0.0025 0.0054 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0689 0.2325
Loa Loa (eye worm) AUR protein kinase 0.0078 0.0712 0.1065
Echinococcus granulosus serine:threonine protein kinase N2 0.0034 0.0163 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0008 0.001
Onchocerca volvulus 0.0021 0.0012 0.0008
Echinococcus multilocularis cyclin dependent kinase 9 0.0065 0.0548 0.0548
Brugia malayi p70 ribosomal S6 kinase beta 0.0058 0.0466 0.0696
Loa Loa (eye worm) AGC/PKA protein kinase 0.0059 0.0473 0.0708
Entamoeba histolytica protein kinase domain containing protein 0.0024 0.0046 0.012
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.011 0.0124
Entamoeba histolytica protein kinase, putative 0.0133 0.1384 0.3755
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0027 0.0038
Echinococcus multilocularis serine protein kinase ATM 0.0042 0.0262 0.0262
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0447 0.0669
Brugia malayi nuclear receptor NHR-88 0.0021 0.0008 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0236 0.0353
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0034 0.0163 0.0244
Plasmodium vivax SET domain protein, putative 0.0029 0.0108 0.0769
Plasmodium falciparum protein kinase, putative 0.0024 0.0046 0.0319
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0021 0.0012 0.0014
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0027 0.0186
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Echinococcus granulosus cyclin dependent kinase 9 0.0075 0.0664 0.0751
Echinococcus granulosus serine:threonine protein kinase NLK 0.002 0.0001 0.0002
Echinococcus granulosus tyrosine kinase 0.0021 0.0012 0.0014
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0038 0.0218 0.1248
Schistosoma mansoni hypothetical protein 0.0087 0.0814 0.0919
Echinococcus multilocularis CDC7 cell division cycle 7 0.0079 0.072 0.072
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0854 0.2316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Loa Loa (eye worm) hypothetical protein 0.0046 0.0319 0.0478
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0712 0.193
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.006 0.0486 0.0486
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0059 0.0473 0.0706
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0036 0.0188 0.135
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0024 0.0046 0.0164
Onchocerca volvulus 0.0079 0.072 0.1068
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0689 0.3959
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.006 0.0486 0.0728
Entamoeba histolytica hypothetical protein 0.0067 0.0576 0.156
Schistosoma mansoni protein kinase 0.0024 0.0046 0.005
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.003 0.0116 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0536 0.1453
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0048 0.034 0.034
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.0689 0.2325
Loa Loa (eye worm) hypothetical protein 0.019 0.2071 0.3099
Brugia malayi hypothetical protein 0.0031 0.0132 0.0196
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0018
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.1146 0.659
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0236 0.0638
Echinococcus granulosus roundabout 2 0.0045 0.0297 0.0335
Schistosoma mansoni survival motor neuron protein 0.005 0.0361 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0271 0.0305
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0414 0.1373
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0112
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0038 0.022 0.0319
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0689 0.4025
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0024 0.0046 0.0046
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0103 0.1011 0.5808
Brugia malayi Tyrosine-protein kinase abl-1 0.0125 0.1275 0.1907
Echinococcus granulosus GPCR family 2 0.006 0.0486 0.0549
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.003 0.0116 0.0131
Brugia malayi SH2 domain containing protein 0.0021 0.0012 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0236 0.1351
Onchocerca volvulus 0.011 0.1097 0.1632
Brugia malayi hypothetical protein 0.0141 0.1478 0.221
Trypanosoma brucei cdc2-related kinase 1 0.0114 0.1146 0.659
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0008 0.0008
Schistosoma mansoni nephrin 0.004 0.0241 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0536 0.1453
Onchocerca volvulus 0.004 0.0236 0.0343
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.0161
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Echinococcus multilocularis insulin receptor 0.017 0.1831 0.1831
Schistosoma mansoni tyrosine kinase 0.0071 0.0616 0.0695
Echinococcus multilocularis 0.0021 0.0005 0.0005
Loa Loa (eye worm) SRC-1 0.0029 0.011 0.0165
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0008 0.0008
Brugia malayi Protein kinase domain containing protein 0.0079 0.072 0.1075
Schistosoma mansoni fkbp-rapamycin associated protein 0.0026 0.0076 0.0084
Onchocerca volvulus 0.0034 0.0164 0.0235
Brugia malayi Protein kinase c protein 2 0.0067 0.0576 0.086
Entamoeba histolytica protein kinase, putative 0.003 0.0116 0.031
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0029 0.011 0.0124
Onchocerca volvulus 0.0029 0.0108 0.0151
Echinococcus granulosus geminin 0.0743 0.8846 1
Onchocerca volvulus 0.0027 0.0076 0.0104
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.1634 0.2444
Mycobacterium tuberculosis Conserved protein 0.004 0.0236 0.0742
Echinococcus granulosus serine threonine protein kinase 0.0133 0.1384 0.1564
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0125 0.1276 0.1276
Entamoeba histolytica protein kinase, putative 0.003 0.0116 0.031
Giardia lamblia Kinase, STE STE20 0.003 0.0116 0.031
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.006 0.0486 0.0486
Entamoeba histolytica protein kinase, putative 0.0078 0.0712 0.193
Echinococcus granulosus expressed conserved protein 0.0197 0.2164 0.2447
Trichomonas vaginalis glutaminase, putative 0.0255 0.2874 0.7805
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0059 0.0473 0.2716
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0447 0.0669
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0132 0.1369 0.1369
Brugia malayi protein kinase C II. 0.0042 0.0271 0.0404
Loa Loa (eye worm) hypothetical protein 0.0034 0.0163 0.0244
Echinococcus multilocularis roundabout 2 0.0045 0.0297 0.0297
Toxoplasma gondii AGC kinase 0.0059 0.0473 0.3987
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0059 0.0473 0.2716
Echinococcus granulosus hemicentin 1 0.0038 0.022 0.0249
Echinococcus granulosus Niemann Pick C1 protein 0.021 0.232 0.2623
Loa Loa (eye worm) beta-lactamase 0.004 0.0236 0.0353
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0447 0.0667
Echinococcus multilocularis Immunoglobulin 0.0033 0.0153 0.0153
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0033 0.0153 0.0153
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0236 0.0742
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0036 0.0188 0.1074
Loa Loa (eye worm) AGC/PKA protein kinase 0.0059 0.0473 0.0708
Trypanosoma brucei developmentally regulated phosphoprotein 0.0144 0.151 0.8683
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0103 0.1011 0.2741
Onchocerca volvulus 0.0231 0.2575 0.3847
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0078 0.0712 0.0805
Echinococcus granulosus tyrosine protein kinase Lyn 0.004 0.0243 0.0275
Giardia lamblia Kinase, CMGC CDK 0.0114 0.1146 0.3111
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0473
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0238 0.2666 0.2666
Trichomonas vaginalis STE family protein kinase 0.0133 0.1384 0.3755
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0046 0.0254
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.1146 0.3111
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.021 0.232 0.6299
Loa Loa (eye worm) glutaminase 0.0255 0.2874 0.4302
Trypanosoma cruzi polo-like protein kinase, putative 0.0125 0.1276 0.7337
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.019 0.2071 0.3097
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0238 0.2666 0.3013
Entamoeba histolytica protein kinase, putative 0.0058 0.0466 0.1262
Schistosoma mansoni kinase 0.0065 0.0548 0.0618
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0565 0.6664 0.7534
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0588 0.1594
Loa Loa (eye worm) TK/ABL protein kinase 0.027 0.306 0.4579
Echinococcus multilocularis epidermal growth factor receptor 0.0084 0.0777 0.0777
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0008 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.1276 0.1441
Plasmodium vivax hypothetical protein, conserved 0.004 0.0236 0.1698
Echinococcus granulosus tyrosine kinase 0.0021 0.0012 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0262 0.0708
Schistosoma mansoni protein kinase 0.003 0.0116 0.0129
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0008 0.0008
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0103 0.1011 0.1011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0452 0.3262
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0103 0.1011 0.5808
Echinococcus multilocularis lamin dm0 0.0057 0.0447 0.0447
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0368 0.0551
Brugia malayi Serine/threonine-protein kinase SULU 0.0238 0.2666 0.3988
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0008 0.0008
Schistosoma mansoni tyrosine kinase 0.0084 0.0777 0.0877
Leishmania major developmentally regulated phosphoprotein-like protein 0.0144 0.151 0.8683
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.005 0.0367 0.3032
Trichomonas vaginalis esterase, putative 0.004 0.0236 0.0638
Brugia malayi latrophilin 2 splice variant baaae 0.013 0.1337 0.1999
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0212 0.235 0.235
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0114 0.1146 0.1296
Brugia malayi SH2 domain containing protein 0.0021 0.0012 0.0016
Echinococcus multilocularis tyrosine protein kinase Abl 0.0125 0.1275 0.1275
Schistosoma mansoni transcription factor LCR-F1 0.0067 0.0576 0.0649
Giardia lamblia Kinase, CDC7 0.0079 0.072 0.1952
Mycobacterium ulcerans lipase LipD 0.004 0.0236 0.0734
Brugia malayi nuclear hormone receptor 0.0021 0.0008 0.001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0021 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0536 0.1453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0537 0.1456
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.017 0.1831 0.1831
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0008 0.0012
Leishmania major phosphatidylinositol 3-kinase, putative 0.0047 0.0327 0.1872
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.0335 0.0378
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.0689 0.2349
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0029 0.011 0.011
Echinococcus multilocularis cyclin dependent kinase 5 0.0114 0.1146 0.1146
Toxoplasma gondii non-specific serine/threonine protein kinase 0.003 0.0113 0.0768
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.0689 0.2325
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0008 0.0009
Schistosoma mansoni tyrosine kinase 0.017 0.1831 0.2069
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0103 0.1011 0.5808
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0236 0.0742
Echinococcus granulosus lamin dm0 0.0057 0.0447 0.0505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0008 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0008 0.001
Echinococcus multilocularis protein dispatched 1 0.0103 0.101 0.101
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0008 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.072 0.1952
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Echinococcus granulosus Niemann Pick C1 protein 0.03 0.3422 0.3869
Echinococcus multilocularis nervana 2 0.0025 0.0055 0.0055
Echinococcus granulosus tyrosine protein kinase Srms 0.0021 0.0012 0.0014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2232 0.3341
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0114 0.1146 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0021 0.0012 0.0014
Brugia malayi hypothetical protein 0.0244 0.274 0.41
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0042 0.0262 0.0295
Onchocerca volvulus 0.0021 0.0012 0.0008
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0163 0.0163
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Giardia lamblia Kinase, CMGC CDK 0.0114 0.1146 0.3111
Echinococcus multilocularis raf serine:threonine protein kinase 0.002 0.0002 0.0002
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0059 0.0473 0.2716
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0008 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0712 0.193
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0008 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Echinococcus multilocularis epidermal growth factor receptor 0.0084 0.0777 0.0777
Plasmodium falciparum glycogen synthase kinase 3 0.0068 0.0588 0.4246
Brugia malayi Protein kinase domain containing protein 0.0114 0.1146 0.1714
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0034 0.0163 0.0244
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0041
Onchocerca volvulus 0.0021 0.0012 0.0008
Schistosoma mansoni tyrosine kinase 0.0021 0.0012 0.0012
Echinococcus multilocularis tyrosine protein kinase Blk 0.0021 0.0012 0.0012
Echinococcus multilocularis plexin a4 0.0025 0.0054 0.0054
Schistosoma mansoni tyrosine kinase 0.0071 0.0616 0.0695
Echinococcus granulosus activin receptor type 0.0024 0.0046 0.0051
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0029 0.011 0.0124
Brugia malayi Protein kinase domain containing protein 0.0212 0.2351 0.3516
Onchocerca volvulus 0.0046 0.0319 0.0468
Loa Loa (eye worm) hypothetical protein 0.021 0.232 0.3472
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0024 0.0046 0.0051
Echinococcus granulosus low density lipoprotein receptor ldl 0.0027 0.0076 0.0086
Echinococcus granulosus c src tyrosine kinase 0.0029 0.011 0.0124
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0004
Schistosoma mansoni titin 0.0038 0.022 0.0247
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0026 0.0076 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0631 0.1711
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0059 0.0473 0.2716
Onchocerca volvulus 0.0141 0.1478 0.2204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0586 0.1589
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0535
Echinococcus multilocularis serine:threonine protein kinase NLK 0.002 0.0001 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0008 0.0008
Echinococcus granulosus protein kinase c iota type 0.0041 0.0253 0.0286
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0027 0.0038
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0068 0.0588 0.088
Echinococcus granulosus cyclin dependent kinase 1 0.0114 0.1146 0.1296
Trypanosoma brucei aurora B kinase 0.0078 0.0712 0.4089
Brugia malayi Niemann-Pick C1 protein precursor 0.021 0.232 0.3471
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.274 0.274
Schistosoma mansoni coup transcription factor 0.0021 0.0008 0.0008
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0008 0.0009
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0157 0.1672 0.5837
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0108 0.072
Onchocerca volvulus 0.0021 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0212 0.2351 0.3518
Echinococcus multilocularis Immunoglobulin 0.0033 0.0153 0.0153
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0321 0.3682 1
Giardia lamblia Kinase, PLK 0.0125 0.1276 0.3463
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.002 0.0001 0.0002
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0021 0.0012 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0631 0.1711
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0218 0.0589
Brugia malayi plexin A 0.0025 0.0054 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Loa Loa (eye worm) hypothetical protein 0.0071 0.0621 0.093
Brugia malayi intracellular kinase 0.0068 0.0588 0.0878
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0072 0.0631 0.3625
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0068 0.0588 0.0664
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0163 0.044
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0367 0.2101
Onchocerca volvulus Netrin receptor homolog 0.0034 0.0164 0.0235
Echinococcus granulosus cyclin dependent kinase 0.0114 0.1146 0.1296
Brugia malayi ecdysteroid receptor 0.0021 0.0008 0.001
Entamoeba histolytica protein kinase, putative 0.0068 0.0588 0.1594
Echinococcus granulosus plexin a4 0.0025 0.0054 0.0061
Echinococcus multilocularis Niemann Pick C1 protein 0.021 0.232 0.232
Onchocerca volvulus 0.004 0.0236 0.0343
Loa Loa (eye worm) AGC/PKN protein kinase 0.0034 0.0163 0.0244
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0283 0.1619
Giardia lamblia Kinase, CMGC MAPK 0.0072 0.0631 0.1711
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0108 0.012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0008 0.001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0099 0.0963 0.1442
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0452 0.3262
Echinococcus granulosus insulin receptor 0.017 0.1831 0.207
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0068 0.0588 0.5014
Brugia malayi intermediate filament protein 0.0057 0.0447 0.0667
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0008 0.0008
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0712 0.193
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.1146 0.659
Entamoeba histolytica protein kinase , putative 0.0078 0.0712 0.193
Brugia malayi kinase, mitochondrial precursor 0.0144 0.151 0.2258
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0259 0.2918 0.4367
Brugia malayi cell division control protein 2 homolog 0.0114 0.1146 0.1714
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.2539 0.2869
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0588 0.1594
Echinococcus multilocularis protein kinase shaggy 0.0068 0.0588 0.0588
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0162 0.1739 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0072 0.0631 0.0714
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0008 0.0008
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0027 0.0076 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0473 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0008 0.001
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0002 0.0000097908
Echinococcus granulosus lamin 0.0057 0.0447 0.0505
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.1146 0.659
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0068 0.0588 0.0665
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0103 0.1011 0.1142
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0027 0.007
Entamoeba histolytica protein kinase, putative 0.0034 0.0163 0.044
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.3533 0.3994
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0008 0.0008
Brugia malayi Latrophilin receptor protein 2 0.006 0.0486 0.0725
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0008 0.001
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0087 0.0099
Loa Loa (eye worm) STE/STE20/YSK protein kinase 0.0133 0.1384 0.2071
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.003 0.0116 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0203
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0008 0.001
Echinococcus multilocularis GPCR, family 2 0.006 0.0486 0.0486
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0236 0.1351
Brugia malayi Protein kinase domain containing protein 0.0099 0.0967 0.1445
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0236 0.0265
Loa Loa (eye worm) hypothetical protein 0.0027 0.0087 0.0131
Loa Loa (eye worm) hypothetical protein 0.025 0.281 0.4206
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0033 0.0152 0.0864
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0236 0.0742
Schistosoma mansoni serine/threonine protein kinase 0.004 0.024 0.027
Schistosoma mansoni kinase 0.0068 0.059 0.0665
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0108 0.0108
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0504 0.1364
Brugia malayi SRC-1 0.0029 0.011 0.0162
Schistosoma mansoni tyrosine kinase 0.0029 0.011 0.0123
Echinococcus multilocularis Niemann Pick C1 protein 0.03 0.3422 0.3422
Echinococcus multilocularis MAM 0.0034 0.0168 0.0168
Brugia malayi map kinase activated protein kinase protein 2 0.0228 0.2539 0.3798
Leishmania major protein kinase, putative 0.0024 0.0046 0.0254
Schistosoma mansoni protein kinase 0.0203 0.2234 0.2524
Echinococcus granulosus tumor protein p63 0.0317 0.3628 0.4102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0537 0.1456
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0008 0.0008
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.1146 0.1716
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.015 0.1583 0.2367
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0303
Giardia lamblia Fructose-bisphosphate aldolase 0.0321 0.3682 1
Brugia malayi serine/threonine-protein kinase 6 0.0078 0.0712 0.1063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0192
Brugia malayi serine/threonine kinase 12 0.0078 0.0712 0.1063
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0144 0.151 0.8683
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0854 0.0964
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0059 0.0473 0.3414
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Schistosoma mansoni tyrosine kinase 0.0262 0.296 0.3345
Onchocerca volvulus 0.005 0.0361 0.0531
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0086 0.0801 0.4601
Schistosoma mansoni hypothetical protein 0.006 0.0486 0.0547
Trichomonas vaginalis STE family protein kinase 0.0133 0.1384 0.3755
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.003 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Echinococcus granulosus cyclin dependent kinase 9 0.0065 0.0548 0.062
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0124 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0854 0.0964
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0084 0.0777 0.1162
Brugia malayi Plexin repeat family protein 0.0021 0.0007 0.0009
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0026 0.0076 0.0203
Entamoeba histolytica protein kinase, putative 0.0032 0.0146 0.0393
Entamoeba histolytica serine/threonine protein kinase, putative 0.0125 0.1276 0.3463
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.1146 0.3111
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0548 0.0618
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0162 0.1739 1
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0008 0.0009
Schistosoma mansoni tyrosine kinase 0.0084 0.0777 0.0877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0008 0.001
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0162 0.1739 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0059 0.0473 0.2716
Brugia malayi CHE-14 protein 0.009 0.0854 0.1276
Loa Loa (eye worm) hypothetical protein 0.0037 0.0209 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0163 0.0183
Loa Loa (eye worm) haspin protein kinase 0.002 0.0001 0.0002
Schistosoma mansoni protein kinase 0.003 0.0116 0.0129
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0047 0.0327 0.1872
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0008 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0689 0.2349
Trypanosoma cruzi target of rapamycin kinase 3 0.0086 0.0801 0.4601
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0103 0.1011 0.5808
Loa Loa (eye worm) IKK protein kinase 0.0566 0.6682 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1562 0.2338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0108 0.012
Brugia malayi MH2 domain containing protein 0.0231 0.2577 0.3856
Echinococcus granulosus mitogen activated protein kinase 0.0072 0.0631 0.0714
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0144 0.151 0.151
Mycobacterium tuberculosis Conserved protein 0.004 0.0236 0.0742
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0236 0.0638
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0095 0.0107
Echinococcus multilocularis mitogen activated protein kinase 11 0.0162 0.1739 0.1739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.0252
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0125 0.1276 0.7337
Entamoeba histolytica cell division protein kinase 2, putative 0.0123 0.1263 0.3426
Entamoeba histolytica protein kinase, putative 0.0078 0.0712 0.193
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0236 0.1351
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0078 0.0712 0.193
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.072 0.1952
Loa Loa (eye worm) hypothetical protein 0.0045 0.0297 0.0444
Onchocerca volvulus Putative titin 0.0034 0.0164 0.0235
Onchocerca volvulus 0.0022 0.0027 0.003
Entamoeba histolytica protein kinase, putative 0.0032 0.0146 0.0393
Loa Loa (eye worm) hypothetical protein 0.0057 0.0447 0.0669
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0194 0.0522
Schistosoma mansoni protein kinase 0.0024 0.0046 0.005
Schistosoma mansoni tyrosine kinase 0.0021 0.0012 0.0012
Onchocerca volvulus Tyrosine kinase homolog 0.0255 0.2873 0.4294
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0072 0.0631 0.3625
Entamoeba histolytica protein kinase, putative 0.0061 0.0496 0.1345
Trypanosoma brucei protein kinase, putative 0.0068 0.0588 0.3378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.1011 0.2741
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0163 0.044
Echinococcus granulosus tyrosine protein kinase Src64B 0.0029 0.011 0.0124
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0021 0.0012 0.0012
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0236 0.0742
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0103 0.1011 0.1511
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0072 0.0631 0.3625
Echinococcus granulosus sterol regulatory element binding protein 0.009 0.0854 0.0965
Brugia malayi Protein kinase domain containing protein 0.0566 0.6682 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0236 0.0638
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0712 0.0803
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0236 0.0742
Echinococcus multilocularis mitogen activated protein kinase 0.0072 0.0631 0.0631
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0078 0.0712 0.193
Schistosoma mansoni pyruvate dehydrogenase 0.0136 0.1412 0.1595
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0033 0.0153 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1583 0.1788
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.011 0.011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.006 0.0486 0.0549
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.002 0.0003 0.0003
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0473
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.1146 0.1716
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0367 0.2101
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0008 0.0009
Echinococcus granulosus tyrosine protein kinase Src42A 0.0029 0.011 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.026 0.293 0.3311
Plasmodium falciparum protein kinase 5 0.0114 0.1146 0.8284
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0034 0.0163 0.0163
Brugia malayi beta-lactamase family protein 0.004 0.0236 0.0351
Echinococcus granulosus insulin growth factor 1 receptor beta 0.017 0.1831 0.207
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0027 0.007
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0047 0.0327 0.0368
Schistosoma mansoni hypothetical protein 0.0087 0.0814 0.0919
Brugia malayi cell division control protein 2 homolog 0.011 0.1097 0.1639
Trypanosoma cruzi Protein kinase B 0.0038 0.0218 0.1248
Echinococcus granulosus serine/threonine protein kinase 0.0038 0.0218 0.0247
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0008 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Echinococcus multilocularis cyclin dependent kinase 9 0.0075 0.0664 0.0664
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0537 0.1456
Echinococcus granulosus serine protein kinase ATM 0.0042 0.0262 0.0296
Onchocerca volvulus 0.0022 0.0027 0.003
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0473
Trypanosoma brucei protein kinase, putative 0.0081 0.0747 0.4294
Schistosoma mansoni hypothetical protein 0.0743 0.8846 1
Entamoeba histolytica hypothetical protein 0.0042 0.0262 0.0708
Echinococcus multilocularis tyrosine protein kinase shark 0.0021 0.0012 0.0012
Schistosoma mansoni serine/threonine-protein kinase 0.0038 0.0218 0.0245
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0067 0.0576 0.0651
Brugia malayi serine/threonine-protein kinase plk-2 0.0125 0.1276 0.1908
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0361 0.0539
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0103 0.1011 0.2741
Echinococcus multilocularis activin receptor type 0.0024 0.0046 0.0046
Loa Loa (eye worm) TK protein kinase 0.0139 0.1456 0.218
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0236 0.0742
Leishmania major protein kinase A catalytic subunit isoform 2 0.0059 0.0473 0.2716
Loa Loa (eye worm) AUR protein kinase 0.0078 0.0712 0.1065
Echinococcus multilocularis nervana 2 0.0025 0.0055 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0037 0.0209 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Onchocerca volvulus 0.004 0.0236 0.0343
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.1583 0.1789
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0029 0.011 0.011
Leishmania major protein kinase A catalytic subunit isoform 1 0.0059 0.0473 0.2716
Loa Loa (eye worm) AUR protein kinase 0.0078 0.0712 0.1065
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0076 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0008 0.001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0023 0.0029 0.0043
Echinococcus granulosus intermediate filament protein 0.0057 0.0447 0.0505
Trypanosoma cruzi polo-like protein kinase, putative 0.0125 0.1276 0.7337
Schistosoma mansoni protein kinase 0.0078 0.0712 0.0803
Echinococcus multilocularis serine:threonine protein kinase NIM1 0.011 0.1097 0.1097
Echinococcus granulosus NDR protein kinase 0.0034 0.0163 0.0185
Brugia malayi serine/threonine protein kinase 6 0.0078 0.0712 0.1063
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0114 0.1146 0.1716
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Echinococcus granulosus aurora kinase A 0.0078 0.0712 0.0805
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0112
Onchocerca volvulus 0.0034 0.0168 0.0241
Brugia malayi beta-lactamase family protein 0.004 0.0236 0.0351
Loa Loa (eye worm) hypothetical protein 0.0554 0.6531 0.9774
Onchocerca volvulus 0.0022 0.0027 0.003
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0086 0.0801 0.4601
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0327 0.1872
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0036 0.0188 0.135
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0231 0.258 0.3862
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.0689 0.2325
Echinococcus granulosus twitchin 0.0051 0.0374 0.0423
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0047 0.0327 0.0327
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.0144 0.151 0.226
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0072 0.0631 0.5397
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0034 0.0163 0.0244
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0631 0.1711
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0163 0.0163
Leishmania major hypothetical protein, conserved 0.004 0.0236 0.1351
Brugia malayi Pre-SET motif family protein 0.0029 0.0108 0.0159
Echinococcus granulosus tyrosine protein kinase ABL1 0.027 0.306 0.3459
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0262 0.039
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0078 0.0712 0.0712
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.0335 0.0335
Echinococcus granulosus neuroglian 0.004 0.0241 0.0272
Entamoeba histolytica hypothetical protein 0.0067 0.0576 0.156
Giardia lamblia Aurora kinase 0.0078 0.0712 0.193
Onchocerca volvulus 0.0068 0.0588 0.0871
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0689 0.103
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0027 0.007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.006 0.0486 0.0549
Schistosoma mansoni patched 1 0.009 0.0854 0.0964
Plasmodium vivax glycogen synthase kinase 3, putative 0.0068 0.0588 0.4246
Toxoplasma gondii target of rapamycin (TOR), putative 0.0081 0.0747 0.643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0008 0.0012
Loa Loa (eye worm) glutaminase 2 0.0255 0.2874 0.4302
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Echinococcus multilocularis tyrosine kinase 0.0021 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0048 0.034 0.0384
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0108 0.012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0008 0.0008
Echinococcus granulosus mitogen activated protein kinase 14 0.0162 0.1739 0.1966
Schistosoma mansoni hypothetical protein 0.0034 0.0168 0.0188
Leishmania major phosphatidylinositol kinase related protein, putative 0.0024 0.0049 0.0271
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0236 0.0638
Loa Loa (eye worm) hypothetical protein 0.0099 0.0963 0.1442
Giardia lamblia Kinase, CMGC GSK 0.0068 0.0588 0.1594
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0034 0.0163 0.0163
Echinococcus multilocularis PAK box P21 Rho binding 0.003 0.0116 0.0116
Plasmodium vivax protein kinase Crk2 0.0114 0.1146 0.8284
Echinococcus multilocularis rac serine:threonine kinase 0.0038 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0033 0.0155 0.0231
Echinococcus granulosus epidermal growth factor receptor 0.0084 0.0777 0.0878
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0689 0.4025
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0068 0.0588 0.3378
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0047 0.0324 0.1855
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0008 0.0008
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.1011 0.2741
Toxoplasma gondii FATC domain-containing protein 0.0042 0.0262 0.2099
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0689 0.2325
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0319 0.0359
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0059 0.0473 0.3987
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.072 0.1952
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0236 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0496 0.1344
Schistosoma mansoni tyrosine kinase 0.0029 0.011 0.0123
Trypanosoma brucei cdc2-related kinase 3 0.0114 0.1146 0.659
Schistosoma mansoni tyrosine kinase 0.0132 0.1369 0.1546
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0008 0.0008
Leishmania major protein kinase, putative 0.0078 0.0712 0.4089
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0236 0.0742
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0042 0.0271 0.0406
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0367 0.2101
Echinococcus granulosus Cell division cycle 2 protein kinase 0.002 0.0001 0.0002
Echinococcus granulosus MAM 0.0034 0.0168 0.019
Brugia malayi Hr1 repeat family protein 0.0034 0.0163 0.0242
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0163 0.0183
Schistosoma mansoni vesicular amine transporter 0.0033 0.0153 0.0171
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.002 0.0003 0.0003
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0712 0.193
Echinococcus multilocularis Protein kinase C, brain isozyme 0.009 0.0854 0.0854
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0327 0.0489
Loa Loa (eye worm) hypothetical protein 0.0055 0.0424 0.0634
Brugia malayi beta-lactamase 0.004 0.0236 0.0351
Schistosoma mansoni tyrosine kinase 0.0084 0.0777 0.0877
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0689 0.1868
Mycobacterium ulcerans hypothetical protein 0.004 0.0236 0.0734
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0029 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0011
Brugia malayi Calcitonin receptor-like protein seb-1 0.019 0.2071 0.3097
Schistosoma mansoni glutaminase 0.0255 0.2874 0.3248
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.3533 0.3993
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0327 0.0487
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0548 0.1485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0535
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0689 0.1868
Schistosoma mansoni tyrosine kinase 0.0032 0.0143 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Trypanosoma brucei rac serine-threonine kinase, putative 0.0061 0.0496 0.2849
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0027 0.0038
Schistosoma mansoni hypothetical protein 0.0034 0.0168 0.0188
Brugia malayi P38 map kinase family protein 2 0.0162 0.1739 0.2601
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.1146 0.3111
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0203 0.2234 0.3343
Treponema pallidum fructose-bisphosphate aldolase 0.0321 0.3682 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0029 0.011 0.0123
Mycobacterium ulcerans glutaminase 0.0255 0.2874 1
Onchocerca volvulus 0.0027 0.0076 0.0104
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0228 0.2539 0.2539
Schistosoma mansoni tyrosine kinase 0.0071 0.0616 0.0695
Entamoeba histolytica protein kinase, putative 0.0061 0.0496 0.1345
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0163 0.0183
Loa Loa (eye worm) AGC/NDR protein kinase 0.0034 0.0163 0.0244
Echinococcus multilocularis Glutaredoxin protein 5 0.0025 0.0055 0.0055
Schistosoma mansoni protein kinase 0.003 0.0116 0.0129
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0218 0.0589
Loa Loa (eye worm) hypothetical protein 0.011 0.1102 0.1649
Onchocerca volvulus 0.0021 0.0012 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0031 0.0132 0.0148
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.015 0.1583 0.2369
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0631 0.0712
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0169
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0058 0.0464 0.3906
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0114
Toxoplasma gondii AGC kinase 0.0059 0.0473 0.3987
Loa Loa (eye worm) TK/INSR protein kinase 0.017 0.1831 0.2741
Brugia malayi cyclin-dependent kinase 9 0.0065 0.0548 0.0818
Echinococcus multilocularis sterol regulatory element binding protein 0.009 0.0854 0.0854
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0058 0.0466 0.0698
Schistosoma mansoni lamin 0.0057 0.0447 0.0504
Onchocerca volvulus 0.0034 0.0168 0.0241
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.2666 0.3012
Schistosoma mansoni pyruvate dehydrogenase 0.0136 0.1412 0.1595
Echinococcus multilocularis protein kinase c iota type 0.0041 0.0253 0.0253
Brugia malayi hypothetical protein 0.0033 0.0153 0.0227
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0473 0.0534
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0565 0.6664 0.6664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.1011 0.2741
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0072 0.0631 0.3625
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Echinococcus granulosus Glutaredoxin protein 5 0.0025 0.0055 0.0062
Echinococcus granulosus nervana 2 0.0025 0.0055 0.0062
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0046 0.0254
Loa Loa (eye worm) CDC7 protein kinase 0.0079 0.072 0.1077
Schistosoma mansoni tyrosine kinase 0.017 0.1831 0.2069
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0034 0.0163 0.0163
Onchocerca volvulus 0.0057 0.0447 0.0659
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0228 0.2539 0.38
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0008 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.003 0.0116 0.0131
Loa Loa (eye worm) hypothetical protein 0.0108 0.1077 0.1612
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0144 0.151 0.151
Onchocerca volvulus 0.0034 0.0164 0.0235
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0027 0.0041
Loa Loa (eye worm) hypothetical protein 0.0244 0.274 0.4101
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0047 0.0327 0.0369
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0078 0.0712 0.193
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.1146 0.3111
Loa Loa (eye worm) pigment dispersing factor receptor c 0.019 0.2071 0.3099
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0008 0.0008
Mycobacterium ulcerans beta-lactamase 0.004 0.0236 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.076 0.2061
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0327 0.1872
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0157 0.1672 0.5777
Brugia malayi hypothetical protein 0.0067 0.0576 0.0859
Giardia lamblia GTOR 0.0103 0.1011 0.2741
Loa Loa (eye worm) hypothetical protein 0.0077 0.0689 0.1031
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0212 0.235 0.2657
Echinococcus granulosus defective proboscis extension response 0.0033 0.0153 0.0173
Onchocerca volvulus 0.0057 0.0447 0.0659
Chlamydia trachomatis serine/threonine protein kinase 0.026 0.293 1
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0163 0.0183
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0036 0.0188 0.0213
Loa Loa (eye worm) TK protein kinase 0.0021 0.0012 0.0018
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0213 0.236 0.2667
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0034 0.0163 0.0185
Echinococcus granulosus tyrosine protein kinase shark 0.0021 0.0012 0.0014
Trypanosoma brucei polo-like protein kinase 0.0125 0.1276 0.7337
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.011 0.0124
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.0689 0.2325
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0008 0.0008
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0042 0.0262 0.15
Giardia lamblia Kinase, AGC PKA 0.0059 0.0473 0.1282
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Schistosoma mansoni lamin 0.0057 0.0447 0.0504
Loa Loa (eye worm) NEK/NEK6 protein kinase 0.026 0.293 0.4385
Echinococcus granulosus mitogen activated protein kinase 15 0.002 0.0001 0.0002
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0162 0.1739 0.2602
Loa Loa (eye worm) AGC/AKT protein kinase 0.0061 0.0496 0.0743
Loa Loa (eye worm) MH2 domain-containing protein 0.0231 0.2577 0.3857
Echinococcus granulosus serine threonine protein kinase nrc 0.0036 0.0188 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.274 0.3098
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0473 0.1282
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.011 0.0124
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0027 0.0148
Toxoplasma gondii ABC1 family protein 0.004 0.0236 0.1867
Mycobacterium tuberculosis Conserved protein 0.004 0.0236 0.0742
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0042 0.0262 0.15
Schistosoma mansoni hypothetical protein 0.006 0.0486 0.0547
Brugia malayi Furin-like cysteine rich region family protein 0.0084 0.0777 0.116
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0132 0.1369 0.1369
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0033 0.0153 0.0171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.1583 0.1583
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0047 0.0327 0.1872
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0008 0.0008
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0084 0.0777 0.0878
Brugia malayi Protein kinase domain containing protein 0.0061 0.0496 0.0741
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0029 0.011 0.011
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0027 0.0041
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0108 0.0122
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.1456 0.2178
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0114 0.1146 0.659
Schistosoma mansoni hypothetical protein 0.006 0.0486 0.0547
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0008 0.001
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0072 0.0631 0.0945
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0027 0.0038
Echinococcus multilocularis lamin 0.0057 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Entamoeba histolytica hypothetical protein 0.0067 0.0576 0.156
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0059 0.0473 0.3414
Onchocerca volvulus Serine\/threonine kinase homolog 0.0125 0.1276 0.1901
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Echinococcus granulosus epidermal growth factor receptor 0.0084 0.0777 0.0878
Loa Loa (eye worm) hypothetical protein 0.0033 0.0152 0.0227
Echinococcus multilocularis mitogen activated protein kinase 14 0.0162 0.1739 0.1739
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0108 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0008 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0008 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0689 0.103
Echinococcus granulosus Immunoglobulin 0.0033 0.0153 0.0173
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0059 0.0473 0.2716
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0572 0.1549
Schistosoma mansoni hypothetical protein 0.0067 0.0576 0.0649
Schistosoma mansoni hypothetical protein 0.005 0.0361 0.0407
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.009 0.0854 0.1278
Loa Loa (eye worm) hypothetical protein 0.0077 0.0689 0.1031
Plasmodium falciparum protein kinase, putative 0.0133 0.1384 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0549 0.1489
Mycobacterium ulcerans hypothetical protein 0.0077 0.0689 0.2325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Brugia malayi FAT domain containing protein 0.002 0.0003 0.0002
Echinococcus multilocularis tyrosine protein kinase Srms 0.0021 0.0012 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.2845 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0008 0.0008
Echinococcus multilocularis tumor protein p63 0.0317 0.3628 0.3628
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0008 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.1392 0.3779
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0003 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0631 0.1711
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0025 0.0055 0.0062
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Schistosoma mansoni intermediate filament proteins 0.0057 0.0447 0.0504
Toxoplasma gondii aurora kinase 0.0078 0.0712 0.6117
Entamoeba histolytica p21-activated kinase 0.0032 0.0146 0.0393
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0236 0.0265
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.002 0.0001 0.0001
Echinococcus multilocularis geminin 0.0743 0.8846 0.8846
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0689 0.2325
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Schistosoma mansoni hypothetical protein 0.006 0.0486 0.0547
Loa Loa (eye worm) hypothetical protein 0.0086 0.0807 0.1207
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0414 0.1373
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.072 0.0812
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0026 0.0076 0.043
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0236 0.0734
Schistosoma mansoni serine/threonine-protein kinase 0.0038 0.0218 0.0245
Onchocerca volvulus 0.0021 0.0012 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0108 0.012
Echinococcus granulosus CDC7 cell division cycle 7 0.0079 0.072 0.0814
Mycobacterium leprae conserved hypothetical protein 0.004 0.0236 0.1271
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0027 0.0038
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.002 0.0001 0.0002
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0027 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0008 0.001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0236 0.0734
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0027 0.0038
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0023 0.003 0.0078
Brugia malayi Protein kinase domain containing protein 0.0297 0.3388 0.507
Echinococcus multilocularis mitogen activated protein kinase 3 0.0072 0.0631 0.0631
Schistosoma mansoni hypothetical protein 0.002 0.0003 0.0001
Loa Loa (eye worm) oxidoreductase 0.0022 0.0027 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1583 0.1788
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1146 0.1295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.059 0.16
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Schistosoma mansoni hypothetical protein 0.0034 0.0164 0.0184
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0029 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0049 0.0271
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1146 0.1295
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.1583 0.1583
Onchocerca volvulus 0.0077 0.0689 0.1022
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0008 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0689 0.3959
Brugia malayi MAP kinase sur-1 0.0072 0.0631 0.0943
Onchocerca volvulus 0.0021 0.0008 0.0002
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0535
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0157 0.1672 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.1146 0.1146
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0114 0.1146 0.659
Brugia malayi Protein kinase domain containing protein 0.0034 0.0163 0.0242
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Brugia malayi hypothetical protein 0.0238 0.2666 0.3988
Trypanosoma brucei protein kinase, putative 0.0024 0.0046 0.0254
Brugia malayi Protein kinase domain containing protein 0.0034 0.0163 0.0242
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0572 0.1549
Echinococcus multilocularis hemicentin 1 0.0038 0.022 0.022
Echinococcus granulosus cyclin dependent kinase 5 0.0114 0.1146 0.1296
Schistosoma mansoni protein kinase 0.0024 0.0046 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0504 0.1364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Echinococcus multilocularis neuroglian 0.004 0.0241 0.0241
Brugia malayi Serine/threonine-protein kinase Nek7 0.026 0.293 0.4384
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Echinococcus multilocularis mitogen activated protein kinase 11 0.0162 0.1739 0.1739
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0034 0.0163 0.0185
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0026 0.0076 0.0086
Giardia lamblia Kinase, AGC PKA 0.0036 0.0188 0.0507
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.068 0.8068 0.9121
Echinococcus multilocularis musashi 0.0057 0.0447 0.0447
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0047 0.0327 0.1872
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0068 0.0588 0.0588
Entamoeba histolytica protein kinase rad3, putative 0.0026 0.0076 0.0203
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0078 0.0712 0.5139
Trypanosoma cruzi aurora B kinase, putative 0.0078 0.0712 0.4089
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Brugia malayi Pre-SET motif family protein 0.0203 0.2232 0.3339
Echinococcus granulosus contactin 0.0038 0.022 0.0249
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0238 0.2666 0.3989
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0125 0.1276 0.191
Brugia malayi Protein kinase domain 0.003 0.0116 0.0171
Onchocerca volvulus 0.0079 0.072 0.1068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0067 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.013 0.1337 0.2001
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.003 0.0116 0.0116
Onchocerca volvulus 0.0208 0.2301 0.3436
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0027 0.0029
Mycobacterium leprae Probable lipase LipE 0.004 0.0236 0.1271
Brugia malayi protein-tyrosine kinase 0.0021 0.0012 0.0016

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.003 uM Inhibition of human Cdc7 assessed as inhibition of rate of phosphorylation of Mcm2 protein ChEMBL. 19115845
IC50 (functional) = 0.6 uM Antiproliferative activity against human A2780 cells after 72 hrs by luciferase based assay ChEMBL. 19115845

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19115845

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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