Detailed information for compound 1209733

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 420.436 | Formula: C19H20N2O7S
  • H donors: 3 H acceptors: 5 LogP: 3.17 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)Nc1ccc2c(c1)c1ccc(cc1o2)S(=O)(=O)N[C@H](C(=O)O)C(C)C
  • InChi: 1S/C19H20N2O7S/c1-10(2)17(18(22)23)21-29(25,26)12-5-6-13-14-8-11(20-19(24)27-3)4-7-15(14)28-16(13)9-12/h4-10,17,21H,1-3H3,(H,20,24)(H,22,23)/t17-/m0/s1
  • InChiKey: MKAIHDAGQJQAHA-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Macrophage metalloelastase Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 14 (membrane-inserted) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 12 (macrophage elastase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 13 (collagenase 3) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 7 (matrilysin, uterine) Starlite/ChEMBL References
Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 4 Starlite/ChEMBL References
Mus musculus matrix metallopeptidase 12 Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 1 (interstitial collagenase) Starlite/ChEMBL References
Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 5 Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 17 (membrane-inserted) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis a disintegrin and metalloproteinase with Get druggable targets OG5_126771 All targets in OG5_126771
Loa Loa (eye worm) matrixin family protein Get druggable targets OG5_129064 All targets in OG5_129064
Echinococcus granulosus a disintegrin and metalloproteinase with Get druggable targets OG5_126771 All targets in OG5_126771
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) Get druggable targets OG5_129064 All targets in OG5_129064
Brugia malayi ADAM-TS Spacer 1 family protein Get druggable targets OG5_126771 All targets in OG5_126771
Schistosoma japonicum ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative Get druggable targets OG5_126771 All targets in OG5_126771
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129064 All targets in OG5_129064
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126771 All targets in OG5_126771
Echinococcus granulosus matrix metallopeptidase 7 M10 family Get druggable targets OG5_129064 All targets in OG5_129064
Schistosoma japonicum IPR002477,Peptidoglycan-binding domain 1;IPR009070,Peptidoglycan binding-like,domain-containing Get druggable targets OG5_129064 All targets in OG5_129064
Schistosoma mansoni ADAMTS5 peptidase (M12 family) Get druggable targets OG5_126771 All targets in OG5_126771
Brugia malayi Matrixin family protein Get druggable targets OG5_129064 All targets in OG5_129064
Onchocerca volvulus Matrilysin homolog Get druggable targets OG5_129064 All targets in OG5_129064
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) Get druggable targets OG5_129064 All targets in OG5_129064
Schistosoma japonicum ko:K07996 matrix metalloproteinase-16 (membrane-inserted), putative Get druggable targets OG5_129064 All targets in OG5_129064
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster Matrix metalloproteinase 1 Macrophage metalloelastase   465 aa 486 aa 36.6 %
Brugia malayi Matrixin family protein matrix metallopeptidase 1 (interstitial collagenase) 403 aa 401 aa 27.7 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 3 (stromelysin 1, progelatinase) 477 aa 431 aa 34.6 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 12 473 aa 465 aa 32.9 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family Macrophage metalloelastase   465 aa 425 aa 33.2 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 7 (matrilysin, uterine) 267 aa 234 aa 41.0 %
Onchocerca volvulus Macrophage metalloelastase   465 aa 421 aa 30.9 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 13 (collagenase 3) 471 aa 448 aa 34.1 %
Onchocerca volvulus BCL7-like protein homolog Macrophage metalloelastase   465 aa 449 aa 29.8 %
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) Macrophage metalloelastase   465 aa 425 aa 33.2 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 12 (macrophage elastase) 470 aa 467 aa 32.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0144 0.1726
Loa Loa (eye worm) Smad1 0.0025 0.0029 0.0081
Schistosoma mansoni hypothetical protein 0.0502 0.1197 0.3342
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0094 0.0198 0.0548
Loa Loa (eye worm) hypothetical protein 0.0155 0.0347 0.097
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0017 0.0154
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0141 0.039
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.01 0.0213 0.059
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0004 0.001
Schistosoma mansoni smad 0.0025 0.0029 0.0077
Loa Loa (eye worm) hypothetical protein 0.0072 0.0144 0.0402
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Plasmodium falciparum protein kinase 6 0.045 0.1068 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0018 0.0175
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0047 0.0047
Loa Loa (eye worm) matrix metalloproteinase 0.0282 0.0659 0.1841
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.021 0.021
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0004 0.0007
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0012 0.0073
Echinococcus granulosus cathepsin l1 0.0018 0.0012 0.0033
Schistosoma mansoni hypothetical protein 0.0105 0.0225 0.0624
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0019 0.0048
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.3116
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Onchocerca volvulus Matrilysin homolog 0.0282 0.0659 0.3841
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0025 0.0067
Mycobacterium tuberculosis Conserved protein 0.0072 0.0144 0.1285
Loa Loa (eye worm) ryanodine receptor 0.0016 0.0008 0.0022
Mycobacterium ulcerans hypothetical protein 0.0071 0.0141 0.1702
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0002 0.0005
Schistosoma mansoni bromodomain containing protein 0.0263 0.0612 0.1707
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0065 0.0182
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0016 0.0008 0.0022
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0025 0.3493
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.009 0.0793
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0016 0.0008 0.0017
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1476 0.3579 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0047 0.3033
Schistosoma mansoni hypothetical protein 0.0351 0.0826 0.2304
Brugia malayi PHD-finger family protein 0.0104 0.0222 0.0615
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0029 0.0081
Echinococcus granulosus transient receptor potential cation channel 0.0016 0.0008 0.0022
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0173 0.0173
Echinococcus multilocularis cysteine protease 0.0018 0.0012 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0144 0.1726
Loa Loa (eye worm) fibroinase 0.0018 0.0012 0.0033
Brugia malayi Muscleblind-like protein 0.0155 0.0347 0.0966
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0056 0.0056
Onchocerca volvulus 0.0015 0.0004 0.0015
Echinococcus multilocularis solute carrier family 22 0.0015 0.0004 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0141 0.1702
Brugia malayi Matrixin family protein 0.0282 0.0659 0.1838
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.0008 0.0017
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.1092 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0017 0.0042
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0002 0.0005
Onchocerca volvulus 0.0015 0.0004 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0141 0.9809
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.017 0.0383 0.1069
Schistosoma mansoni bromodomain containing protein 0.0018 0.0012 0.0028
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0051 0.0094 0.0258
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus granulosus sex peptide receptor 0.0014 0.0002 0.0005
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0096
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0002 0.0005
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.3116
Echinococcus granulosus smad 0.0025 0.0029 0.0081
Echinococcus granulosus serotonin receptor 0.0014 0.0002 0.0005
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0025 0.0109
Echinococcus granulosus calcium activated potassium channel 0.0022 0.0022 0.0061
Loa Loa (eye worm) hypothetical protein 0.0053 0.0098 0.0272
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Toxoplasma gondii transporter, cation channel family protein 0.0016 0.0008 0.0052
Loa Loa (eye worm) hypothetical protein 0.0123 0.0268 0.075
Schistosoma mansoni glucose transporter 0.0015 0.0004 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0002 0.0005
Echinococcus multilocularis lamin 0.0027 0.0034 0.0034
Echinococcus multilocularis potassium voltage gated channel protein 0.0016 0.0008 0.0008
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0002 0.0005
Mycobacterium ulcerans beta-lactamase 0.0072 0.0144 0.1735
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0002 0.0005
Onchocerca volvulus Papilin homolog 0.0069 0.0137 0.0791
Loa Loa (eye worm) hypothetical protein 0.0072 0.0144 0.0402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0135 0.9373
Echinococcus granulosus histone lysine methyltransferase setb 0.0071 0.0142 0.0396
Toxoplasma gondii transporter, cation channel family protein 0.0016 0.0008 0.0052
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.0056 0.0741
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.0056 0.0487
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0002 0.0005
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0012 0.0073
Echinococcus multilocularis lamin dm0 0.0027 0.0034 0.0034
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0072 0.0144 0.0402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0135 0.9373
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0362 0.0854 0.2382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Brugia malayi Transient-receptor-potential like protein 0.0082 0.017 0.047
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0048 0.0538
Echinococcus multilocularis calcium activated potassium channel 0.0022 0.0022 0.0022
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0002 0.0005
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0065 0.0065
Brugia malayi isocitrate dehydrogenase 0.0032 0.0047 0.0126
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.021 0.0588
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0002 0.0002
Onchocerca volvulus 0.0072 0.0144 0.0832
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0362 0.0854 0.2385
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0017 0.0116
Onchocerca volvulus 0.0016 0.0008 0.0036
Onchocerca volvulus 0.015 0.0336 0.1951
Schistosoma mansoni lamin 0.0027 0.0034 0.0091
Onchocerca volvulus 0.0018 0.0012 0.006
Brugia malayi MH2 domain containing protein 0.0025 0.0029 0.0077
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0127 0.0355
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0016 0.0008 0.0008
Schistosoma mansoni sugar transporter 0.0015 0.0004 0.0007
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0004 0.0012
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0002 0.0002
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0019 0.022
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0026 0.0268
Trypanosoma cruzi hexose transporter 0.0033 0.0048 0.3116
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.0324 0.0906
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Mycobacterium ulcerans hypothetical protein 0.0072 0.0144 0.1735
Toxoplasma gondii protein kinase, putative 0.0301 0.0703 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus multilocularis short transient receptor potential channel 6 0.0139 0.0308 0.0308
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0019 0.0183
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0124 0.0343
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0016 0.0008 0.0022
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0058 0.0769
Toxoplasma gondii cathepsin CPL 0.0018 0.0012 0.0111
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0072 0.0144 0.0402
Schistosoma mansoni glucose transport protein 0.0105 0.0225 0.0624
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0019 0.0019
Echinococcus multilocularis serotonin receptor 0.0014 0.0002 0.0002
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0045 0.6742
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.0008 0.0008
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0002 0.0005
Onchocerca volvulus 0.0021 0.0019 0.0101
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Onchocerca volvulus Putative transporter 0.0015 0.0004 0.0015
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0012 0.006
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0019 0.0183
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0141 0.4065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0045 0.0122
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.0056 0.0487
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0008 0.0052
Echinococcus multilocularis sentrin specific protease 7 0.0148 0.033 0.033
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0017 0.0891
Onchocerca volvulus 0.0018 0.0012 0.006
Leishmania major cathepsin L-like protease 0.0068 0.0135 0.9373
Echinococcus multilocularis solute carrier family 22 0.0015 0.0004 0.0004
Echinococcus granulosus hyperpolarization activated cyclic 0.0016 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.016 0.0359 0.1002
Loa Loa (eye worm) hypothetical protein 0.0069 0.0137 0.0383
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0002 0.0005
Leishmania major cathepsin L-like protease 0.0018 0.0012 0.0554
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0047 0.0047
Trypanosoma brucei glucose transporter 1E 0.0033 0.0048 0.3116
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0056 0.3705
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0016 0.0008 0.0017
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0016 0.0008 0.0036
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0019 0.1054
Brugia malayi voltage-dependent calcium channel 0.0016 0.0008 0.0017
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0065 0.4347
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0098 0.0877
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0016 0.0008 0.0008
Schistosoma mansoni protein kinase 0.0036 0.0056 0.0152
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0344 0.081 0.2258
Echinococcus granulosus lamin dm0 0.0027 0.0034 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Brugia malayi RNA binding protein 0.0064 0.0124 0.0343
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0144 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0324 0.0902
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.0056 0.0487
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0096
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0019 0.1054
Loa Loa (eye worm) voltage-gated calcium channel 0.0016 0.0008 0.0022
Echinococcus granulosus expressed protein 0.0051 0.0094 0.0262
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0017 0.0047
Echinococcus multilocularis transient receptor potential cation channel 0.0016 0.0008 0.0008
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.0056 0.0487
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0019 0.0048
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0019 0.0182
Brugia malayi follicle stimulating hormone receptor 0.026 0.0604 0.1684
Schistosoma mansoni smad1 5 8 and 0.0025 0.0029 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Loa Loa (eye worm) voltage-gated potassium channel 0.0016 0.0008 0.0022
Brugia malayi Bromodomain containing protein 0.0159 0.0358 0.0996
Plasmodium vivax vivapain-2 0.0018 0.0012 0.0073
Leishmania major glucose transporter, lmgt1 0.0033 0.0048 0.3116
Onchocerca volvulus 0.0015 0.0004 0.0015
Echinococcus granulosus transient receptor potential gamma protein 0.0205 0.047 0.1313
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0002 0.0002
Echinococcus granulosus shaker cognate 0.0016 0.0008 0.0022
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0127 0.0351
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0324 0.0906
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0016 0.0008 0.0022
Echinococcus granulosus allatostatin A receptor 0.0014 0.0002 0.0005
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0144 0.1285
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0048 0.0538
Schistosoma mansoni transient receptor potential channel 0.0139 0.0308 0.0857
Schistosoma mansoni sugar transporter 0.0015 0.0004 0.0007
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.0056 0.0487
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0004 0.0012
Brugia malayi hypothetical protein 0.0016 0.0008 0.0017
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0058 0.0058
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0016 0.0008 0.0017
Brugia malayi MH1 domain containing protein 0.0025 0.0029 0.0077
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0016 0.0008 0.0017
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0019 0.0139
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0127 0.1526
Loa Loa (eye worm) hypothetical protein 0.0053 0.0098 0.0272
Schistosoma mansoni protein kinase 0.0036 0.0056 0.0152
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0012 0.0073
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0121 0.8335
Loa Loa (eye worm) bromodomain containing protein 0.0074 0.0148 0.0413
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0137
Echinococcus granulosus g protein coupled receptor 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0219 0.0503 0.1405
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0002 0.0002
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0016 0.0008 0.0017
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0004 0.0004
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0135 0.9373
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0019 0.1054
Echinococcus granulosus General substrate transporter 0.009 0.0189 0.0528
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0127 0.1526
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.0056 0.0487
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0002 0.0005
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0017 0.0891
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0056 0.0156
Loa Loa (eye worm) calcium channel 0.0016 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Brugia malayi jmjC domain containing protein 0.0045 0.0077 0.0211
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0144 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0047 0.3033
Echinococcus granulosus solute carrier family 22 0.0015 0.0004 0.0012
Schistosoma mansoni voltage-dependent calcium channel 0.0016 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0002 0.0002
Onchocerca volvulus 0.0015 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0082 0.017 0.0474
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0016 0.0008 0.0008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0123 0.0342
Onchocerca volvulus Matrilysin homolog 0.0713 0.1713 1
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0144 0.1285
Giardia lamblia PHD finger protein 15 0.003 0.0042 0.6233
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0123 0.0342
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0012 0.0028
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0077 0.0215
Brugia malayi Cam kinase protein 1 0.0036 0.0056 0.0152
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0056 0.0056
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0026 0.1545
Schistosoma mansoni calcium-activated potassium channel 0.0016 0.0008 0.0017
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0019 0.0053
Loa Loa (eye worm) matrixin family protein 0.0626 0.1501 0.4192
Loa Loa (eye worm) hypothetical protein 0.0063 0.0123 0.0342
Echinococcus granulosus neuropeptide receptor A26 0.0964 0.2327 0.6501
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Trypanosoma cruzi ISWI complex protein 0.0064 0.0124 0.8557
Echinococcus multilocularis expressed protein 0.0051 0.0094 0.0094
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.0225 0.3159
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0016 0.0008 0.0022
Mycobacterium tuberculosis Conserved protein 0.0072 0.0144 0.1285
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0124 0.0124
Loa Loa (eye worm) angiogenesis inhibito 0.0034 0.0051 0.0143
Schistosoma mansoni 60S ribosomal protein L21 0.0016 0.0008 0.0017
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0042 0.0118
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0135 0.9373
Echinococcus granulosus two pore calcium channel protein 1 0.0016 0.0008 0.0022
Brugia malayi beta-lactamase family protein 0.0072 0.0144 0.0398
Echinococcus granulosus geminin 0.0502 0.1197 0.3345
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0002 0.0005
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0016 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0136 0.0302 0.0843
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0025 0.1518
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0029 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0019 0.0183
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0033
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0002 0.0005
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0127 0.113
Schistosoma mansoni protein kinase 0.0036 0.0056 0.0152
Loa Loa (eye worm) hypothetical protein 0.0071 0.0141 0.0395
Echinococcus multilocularis voltage dependent calcium channel 0.0016 0.0008 0.0008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0124 0.0348
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0144 0.1735
Brugia malayi map kinase activated protein kinase protein 2 0.1476 0.3579 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0017 0.0178
Schistosoma mansoni intermediate filament proteins 0.0027 0.0034 0.0091
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0096
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0124 0.0348
Brugia malayi hypothetical protein 0.0015 0.0004 0.0007
Echinococcus granulosus microtubule associated protein 2 0.0696 0.1672 0.467
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0047 0.013
Echinococcus multilocularis hyperpolarization activated cyclic 0.0016 0.0008 0.0008
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0019 0.0183
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0002 0.0005
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0016 0.0008 0.0017
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0045 0.0122
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0135 0.9373
Loa Loa (eye worm) hypothetical protein 0.0072 0.0144 0.0402
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0002 0.0002
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0091 0.0192 0.0531
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.0056 0.0487
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0004 0.0012
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0141 0.1702
Schistosoma mansoni hypothetical protein 0.0086 0.0178 0.0493
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1476 0.3579 0.3579
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.0008 0.0022
Echinococcus multilocularis potassium voltage gated channel protein 0.0016 0.0008 0.0008
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0004 0.0007
Onchocerca volvulus 0.0027 0.0034 0.019
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.0225 0.0629
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0016 0.0008 0.0017
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0016 0.0008 0.0008
Echinococcus granulosus orexin receptor type 2 0.0014 0.0002 0.0005
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0127 0.0127
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0016 0.0008 0.0045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0248 0.0576 0.1609
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0002 0.0005
Echinococcus granulosus sodium leak channel non selective protein 0.0016 0.0008 0.0022
Echinococcus granulosus voltage gated potassium channel 0.0016 0.0008 0.0022
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0048 0.0538
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0045 0.0126
Loa Loa (eye worm) hypothetical protein 0.0122 0.0266 0.0744
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0036 0.0056 0.0153
Echinococcus multilocularis geminin 0.0502 0.1197 0.1197
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0002 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0123 0.0123
Echinococcus granulosus g protein coupled receptor 0.0014 0.0002 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0144 0.1314
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0016 0.0008 0.0036
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0141 0.1261
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0002 0.0002
Onchocerca volvulus 0.0015 0.0004 0.0015
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0025 0.0304
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0096
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0141 0.1702
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0002 0.0005
Brugia malayi hypothetical protein 0.0015 0.0004 0.0007
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.3116
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0019 0.1054
Loa Loa (eye worm) hypothetical protein 0.0053 0.0098 0.0272
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0124 0.0343
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0071 0.0142 0.0391
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0127 0.1759
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0056 0.0157
Loa Loa (eye worm) hypothetical protein 0.02 0.0456 0.1275
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0016 0.0008 0.0017
Schistosoma mansoni methyl-cpg binding protein mbd 0.0071 0.0142 0.0391
Echinococcus granulosus transient receptor potential cation channel 0.0016 0.0008 0.0022
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0065 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0012 0.0033
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0016 0.0008 0.0017
Echinococcus granulosus g protein coupled receptor 0.0014 0.0002 0.0005
Leishmania major cathepsin L-like protease 0.0018 0.0012 0.0554
Echinococcus multilocularis conserved hypothetical protein 0.0016 0.0008 0.0008
Echinococcus multilocularis sex peptide receptor 0.0014 0.0002 0.0002
Echinococcus granulosus voltage gated hydrogen channel 1 0.0016 0.0008 0.0022
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0012 0.0532
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0002 0.0005
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Onchocerca volvulus 0.0015 0.0004 0.0015
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0029 0.0077
Schistosoma mansoni sugar transporter 0.0015 0.0004 0.0007
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0045 0.1044
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0144 0.0402
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0124 0.0343
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0002 0.0005
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0042 0.0113
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0016 0.0008 0.0022
Schistosoma mansoni Smad4 0.0025 0.0029 0.0077
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0065 0.0065
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0077 0.0215
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0016 0.0008 0.0017
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0019 0.1054
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0002 0.0005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0144 0.1285
Schistosoma mansoni DNA helicase recq1 0.002 0.0017 0.0042
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.3116
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0144 0.1726
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0065 0.0177
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0071 0.0071
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0029 0.0081
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus granulosus lamin 0.0027 0.0034 0.0096
Loa Loa (eye worm) sugar transporter 0.0015 0.0004 0.0012
Echinococcus granulosus expressed conserved protein 0.0135 0.0299 0.0834
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0144 0.1285
Mycobacterium leprae PROBABLE HYDROLASE 0.0344 0.081 1
Brugia malayi Smad1 0.0025 0.0029 0.0077
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.003 0.0042 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0065 0.075
Toxoplasma gondii TIM10 family protein, putative 0.0051 0.0094 0.1281
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0002 0.0002
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0016 0.0008 0.0017
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0017 0.0116
Onchocerca volvulus 0.0071 0.0141 0.0816
Entamoeba histolytica hypothetical protein 0.0036 0.0056 0.1393
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0123 0.0338
Mycobacterium ulcerans lipase LipD 0.0072 0.0144 0.1735
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0016 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0095 0.0265
Echinococcus multilocularis shaker cognate 0.0016 0.0008 0.0008
Schistosoma mansoni transient receptor potential channel 0.0139 0.0308 0.0857
Echinococcus multilocularis muscleblind protein 0.0155 0.0347 0.0347
Echinococcus granulosus muscleblind protein 0.0155 0.0347 0.097
Toxoplasma gondii hypothetical protein 0.0016 0.0008 0.0052
Toxoplasma gondii transporter, cation channel family protein 0.0016 0.0008 0.0052
Onchocerca volvulus 0.0282 0.0659 0.3841
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0173 0.0392 0.3651
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0026 0.0052
Echinococcus multilocularis potassium large conductance calcium activated 0.0016 0.0008 0.0008
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0026 0.0268
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1476 0.3579 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0065 0.0182
Schistosoma mansoni zinc finger protein 0.0064 0.0124 0.0342
Leishmania major hypothetical protein, conserved 0.0072 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0002 0.0002
Onchocerca volvulus 0.0015 0.0004 0.0015
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0123 0.0342
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0058 0.3844
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0042 0.0042
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0017 0.0154
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0144 0.1285
Brugia malayi Sugar transporter family protein 0.0105 0.0225 0.0624
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0135 0.9373
Loa Loa (eye worm) hypothetical protein 0.0071 0.0141 0.0395
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0017 0.0047
Echinococcus multilocularis musashi 0.0027 0.0034 0.0034
Brugia malayi ADAM-TS Spacer 1 family protein 0.0219 0.0503 0.1402
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0056 0.0153
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0177 0.0402 0.1124
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0016 0.0008 0.0008
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0058 0.3844
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0099 0.6813
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0017 0.0891
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0124 0.0343
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0065 0.0182
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0141 0.9809
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0071 0.0142 0.0142
Echinococcus multilocularis sodium channel protein 0.0016 0.0008 0.0008
Echinococcus multilocularis transfer RNA-Gly 0.0016 0.0008 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0324 0.0906
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0369 0.0872 0.2432
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0029
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0017 0.0117
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0016 0.0008 0.0022
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0002 0.0005
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0091 0.0192 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0065 0.075
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0016 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0016 0.0008 0.0022
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0002 0.0005
Leishmania major hypothetical protein, unknown function 0.0016 0.0008 0.0259
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0019 0.1054
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0071 0.0199
Schistosoma mansoni methyl-cpg binding protein mbd 0.0071 0.0142 0.0391
Leishmania major cathepsin L-like protease 0.0018 0.0012 0.0554
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0042 0.0542
Onchocerca volvulus Alhambra homolog 0.003 0.0042 0.0236
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0161 0.0444
Brugia malayi PHD-finger family protein 0.0018 0.0012 0.0028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0008 0.0017
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0173 0.0484
Brugia malayi PHD-finger family protein 0.003 0.0042 0.0113
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0011 0.0032
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0019 0.0183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0096
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0065 0.4347
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0098 0.1158
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.0056 0.0487
Trypanosoma brucei ISWI complex protein 0.0064 0.0124 0.8557
Brugia malayi cation channel family protein 0.0016 0.0008 0.0017
Echinococcus granulosus neuropeptide s receptor 0.0964 0.2327 0.6501
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0019 0.0048
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0077 0.0211
Loa Loa (eye worm) beta-lactamase 0.0072 0.0144 0.0402
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0019 0.0048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus granulosus Smad4 0.0025 0.0029 0.0081
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0012 0.0033
Loa Loa (eye worm) sugar transporter 0.0105 0.0225 0.0629
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0002 0.0002
Echinococcus granulosus sodium channel protein 0.0016 0.0008 0.0022
Brugia malayi Matrixin family protein 0.072 0.173 0.483
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0025 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0324 0.0902
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0019 0.0135
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.0002 0.0002
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0016 0.0008 0.0008
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0065 0.0065
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0002 0.0002
Echinococcus multilocularis ryanodine receptor 44f 0.0016 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.0016 0.0008 0.0259
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus multilocularis cysteine protease 0.0018 0.0012 0.0012
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0047 0.3033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0002 0.0002
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0016 0.0008 0.0022
Leishmania major cathepsin L-like protease 0.0018 0.0012 0.0554
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0048 0.3116
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.0225 0.0629
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0012 0.0012
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0016 0.0008 0.0259
Echinococcus granulosus voltage dependent calcium channel 0.0016 0.0008 0.0022
Plasmodium falciparum mitogen-activated protein kinase 2 0.0173 0.0392 0.3651
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0141 0.1702
Echinococcus multilocularis hyperpolarization activated cyclic 0.0016 0.0008 0.0008
Echinococcus granulosus potassium large conductance calcium activated 0.0016 0.0008 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0002 0.0002
Onchocerca volvulus 0.0351 0.0826 0.4817
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0086
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0017 0.0042
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0047 0.0399
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0012 0.006
Echinococcus multilocularis bloom syndrome protein 0.002 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus granulosus ryanodine receptor 44f 0.0016 0.0008 0.0022
Entamoeba histolytica hypothetical protein 0.0036 0.0056 0.1393
Loa Loa (eye worm) hypothetical protein 0.0369 0.0872 0.2436
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0019 0.0183
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0042 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0135 0.9373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0135 0.9373
Echinococcus granulosus hyperpolarization activated cyclic 0.0016 0.0008 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0144 0.0398
Echinococcus multilocularis solute carrier family 22 0.0015 0.0004 0.0004
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.3116
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0012 0.0033
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0048 0.0538
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0002 0.0002
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.3116
Echinococcus granulosus fmrfamide receptor 0.0014 0.0002 0.0005
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0127 0.8796
Loa Loa (eye worm) metalloprotease 0.003 0.0041 0.0113
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0019 0.0053
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0077 0.0211
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Brugia malayi hypothetical protein 0.015 0.0336 0.0933
Schistosoma mansoni vesicular amine transporter 0.0016 0.0008 0.0017
Echinococcus granulosus bloom syndrome protein 0.002 0.0017 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Leishmania major cathepsin L-like protease 0.0068 0.0135 0.9373
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0026 0.0114
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0026 0.0309
Brugia malayi metalloprotease 0.003 0.0041 0.0109
Schistosoma mansoni transient receptor potential channel 4 0.0205 0.047 0.1309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0019 0.0135
Loa Loa (eye worm) hypothetical protein 0.0282 0.0659 0.1841
Onchocerca volvulus Huntingtin homolog 0.0122 0.0266 0.1547
Brugia malayi intermediate filament protein 0.0027 0.0034 0.0091
Entamoeba histolytica protein kinase, putative 0.0036 0.0056 0.1384
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0135 0.9373
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0004 0.0007
Brugia malayi hypothetical protein 0.0036 0.0056 0.0153
Schistosoma mansoni DNA helicase recq5 0.002 0.0017 0.0042
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Schistosoma mansoni glucose transport protein 0.0105 0.0225 0.0624
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.009 0.0793
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0002 0.0005
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0034 0.0091
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0025 0.1518
Brugia malayi ADAMTS-like protease 0.0067 0.0132 0.0365
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0019 0.0183
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0047 0.3033
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0002 0.0005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0012 0.0033
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0016 0.0008 0.0017
Onchocerca volvulus 0.0015 0.0004 0.0015
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0056 0.0156
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0002 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.003 0.0042 0.0113
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0008 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0033
Brugia malayi angiogenesis inhibito 0.0067 0.0132 0.0365
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0002 0.0005
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.003 0.0041 0.0109
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0248 0.0576 0.0576
Onchocerca volvulus 0.0015 0.0004 0.0015
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Echinococcus multilocularis zinc finger protein 0.0081 0.0167 0.0167
Schistosoma mansoni glucose transport protein 0.0105 0.0225 0.0624
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0082 0.017 0.017
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0051 0.0094 0.0262
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0173 0.0392 0.5555
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0004 0.0012
Plasmodium falciparum protein kinase 7 0.0301 0.0703 0.6572
Schistosoma mansoni sugar transporter 0.0015 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0135 0.9373
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Brugia malayi Sugar transporter family protein 0.0015 0.0004 0.0007
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0019 0.0135
Loa Loa (eye worm) hypothetical protein 0.0066 0.013 0.0363
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0002 0.0002
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0016 0.0008 0.0022
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0019 0.0135
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Echinococcus granulosus adam 0.0063 0.0121 0.0339
Onchocerca volvulus 0.0018 0.0012 0.006
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0016 0.0008 0.0017
Toxoplasma gondii ABC1 family protein 0.0072 0.0144 0.1999
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0025 0.0067
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0016 0.0008 0.0022
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0016 0.0008 0.0022
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0045 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0144 1
Schistosoma mansoni hypothetical protein 0.0063 0.0123 0.0338
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0141 0.1702
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0025 0.1518
Plasmodium falciparum hexose transporter 0.0105 0.0225 0.2076
Onchocerca volvulus Huntingtin homolog 0.0122 0.0266 0.1547
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.0225 0.0225
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0121 0.0338
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0019 0.0139
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.015 0.0334 0.0933
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0012 0.0029
Schistosoma mansoni zinc finger protein 0.0081 0.0167 0.0463
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0029
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0045 0.0122
Onchocerca volvulus 0.0027 0.0034 0.019
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0019 0.0183
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0148 0.033 1
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0065 0.0182
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0056 0.0152
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0012 0.007
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0048 0.3116
Echinococcus granulosus two pore calcium channel protein 2 0.0016 0.0008 0.0022
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0058 0.0505
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0019 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0135 0.9373
Brugia malayi hypothetical protein 0.0063 0.0121 0.0335
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0019 0.0048
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0016 0.0008 0.0008
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0047 0.0399
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0016 0.0008 0.0017
Echinococcus granulosus GPCR family 2 0.0063 0.0123 0.0342
Echinococcus multilocularis transient receptor potential gamma protein 0.0205 0.047 0.047
Onchocerca volvulus 0.0018 0.0012 0.006
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.003 0.0041 0.0109
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0025 0.02
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0017 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0002 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0017 0.0178
Loa Loa (eye worm) nuclear factor I 0.0014 0.0002 0.0005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0144 0.0398
Plasmodium vivax vivapain-2 0.0018 0.0012 0.0073
Plasmodium vivax CDK-related protein kinase 6, putative 0.045 0.1068 1
Echinococcus multilocularis General substrate transporter 0.009 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus multilocularis potassium voltage gated channel protein 0.0016 0.0008 0.0008
Leishmania major glucose transporter, lmgt2 0.0033 0.0048 0.3116
Echinococcus multilocularis transient receptor potential cation channel 0.0016 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0072 0.0144 0.0402
Brugia malayi Hemopexin family protein 0.0351 0.0826 0.2304
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0016 0.0008 0.0017
Echinococcus granulosus transient receptor potential ion channel A 0.0189 0.043 0.1202
Echinococcus multilocularis two pore calcium channel protein 1 0.0016 0.0008 0.0008
Brugia malayi beta-lactamase family protein 0.0072 0.0144 0.0398
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0113
Echinococcus multilocularis short transient receptor potential channel 6 0.0139 0.0308 0.0308
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0016 0.0008 0.0017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.0456 0.1271
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0063 0.0121 0.0335
Echinococcus multilocularis neuropeptide s receptor 0.0964 0.2327 0.2327
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0012 0.0029
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus multilocularis transient receptor potential cation channel 0.0016 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Echinococcus granulosus somatostatin receptor 0.0014 0.0002 0.0005
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0173 0.048
Echinococcus granulosus sentrin specific protease 7 0.0148 0.033 0.0922
Onchocerca volvulus 0.0015 0.0004 0.0015
Echinococcus multilocularis transient receptor potential cation channel 0.0016 0.0008 0.0008
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0141 0.4065
Leishmania major cathepsin L-like protease 0.0068 0.0135 0.9373
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0048 0.3116
Echinococcus granulosus short transient receptor potential channel 6 0.0139 0.0308 0.0861
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0016 0.0008 0.0008
Brugia malayi MH2 domain containing protein 0.0366 0.0863 0.2407
Leishmania major cathepsin L-like protease 0.0018 0.0012 0.0554
Mycobacterium ulcerans hydrolase 0.0344 0.081 1
Brugia malayi ion channel NompC 0.0016 0.0008 0.0017
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0012 0.0554
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0025 0.02
Echinococcus multilocularis adam 0.0063 0.0121 0.0121
Mycobacterium leprae Probable lipase LipE 0.0072 0.0144 0.1604
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0047 0.0047
Onchocerca volvulus 0.0015 0.0004 0.0015
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0019 0.0211
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0019 0.0211
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Schistosoma mansoni lamin 0.0027 0.0034 0.0091
Echinococcus multilocularis serotonin receptor 0.0014 0.0002 0.0002
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0012 0.006
Echinococcus granulosus hypothetical protein 0.0016 0.0008 0.0022
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0065 0.4347
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0019 0.0135
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0026 0.0203
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0012 0.0096
Echinococcus multilocularis smad 0.0025 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0282 0.0659 0.1841
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0002 0.0005
Brugia malayi MH1 domain containing protein 0.0014 0.0002 0.0001
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0016 0.0008 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0019 0.0183
Entamoeba histolytica hypothetical protein 0.0036 0.0056 0.1393
Onchocerca volvulus 0.0015 0.0004 0.0015
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.0225 0.0629
Entamoeba histolytica protein kinase, putative 0.0036 0.0056 0.1384
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0096
Brugia malayi olfactory channel protein osm-9 0.0016 0.0008 0.0017
Schistosoma mansoni voltage-gated ion channel 0.0016 0.0008 0.0017
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0017 0.0117
Entamoeba histolytica hypothetical protein 0.0024 0.0026 0.0436
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0065 0.075
Brugia malayi TAR-binding protein 0.0064 0.0124 0.0343
Loa Loa (eye worm) hypothetical protein 0.0205 0.047 0.1313
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0019 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0019 0.0183
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0008 0.0017
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0019 0.0135
Echinococcus multilocularis somatostatin receptor 0.0014 0.0002 0.0002
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.3116
Schistosoma mansoni hypothetical protein 0.0063 0.0123 0.0338
Echinococcus granulosus potassium voltage gated channel protein 0.0016 0.0008 0.0022
Toxoplasma gondii hypothetical protein 0.0016 0.0008 0.0052
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.015 0.0334 0.0334
Echinococcus granulosus solute carrier family 22 0.0015 0.0004 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.009 0.0793
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0092
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0019 0.0183
Echinococcus granulosus neuropeptide receptor 0.0014 0.0002 0.0005
Loa Loa (eye worm) PHD-finger family protein 0.0086 0.0178 0.0498
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0002 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0144 0.0398
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.0225 0.0225
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.1064 0.2571 0.7184
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0019 0.0183
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0017 0.0017
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0056 0.0156
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0025 0.0067
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0144 0.1726
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0144 0.1726
Echinococcus granulosus solute carrier family 22 0.0015 0.0004 0.0012
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0144 0.1604
Echinococcus granulosus neuropeptide receptor 0.0014 0.0002 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0096
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0026 0.1545
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0008 0.0017
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0017 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0098 0.0858
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0048 0.0538
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0019 0.0053
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0091 0.0192 0.0535
Echinococcus multilocularis transient receptor potential cation channel 0.0016 0.0008 0.0008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0002 0.0002
Echinococcus multilocularis sodium leak channel non selective protein 0.0016 0.0008 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0141 0.1702
Onchocerca volvulus 0.0015 0.0004 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0124 0.0343
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0056 0.0156
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0141 0.4065
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0124 0.0343
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0016 0.0008 0.0017
Loa Loa (eye worm) RNA binding protein 0.0064 0.0124 0.0348
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0094 0.0198 0.0198
Plasmodium vivax hypothetical protein, conserved 0.003 0.0042 0.0356
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0144 0.1285
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0019 0.1054
Schistosoma mansoni serine/threonine protein kinase 0.1476 0.3579 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0026 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Onchocerca volvulus Matrix metalloproteinase homolog 0.0626 0.1501 0.8757
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0141 0.039
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0025 0.0262
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0029 0.0081
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0002 0.0005
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0065 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0096
Echinococcus multilocularis Smad4 0.0025 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.015 0.0336 0.0937
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Echinococcus granulosus potassium voltage gated channel protein 0.0016 0.0008 0.0022
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0144 0.0402
Brugia malayi major facilitator superfamily protein 0.0015 0.0004 0.0007
Echinococcus granulosus potassium voltage gated channel protein 0.0016 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0347 0.0347
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0051 0.0094 0.0842
Entamoeba histolytica hypothetical protein 0.0036 0.0056 0.1393
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0141 0.039
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0029
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0016 0.0008 0.0259
Plasmodium falciparum phd finger protein, putative 0.003 0.0042 0.0356
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0026 0.0203
Echinococcus multilocularis two pore calcium channel protein 2 0.0016 0.0008 0.0008
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0019 0.1054
Echinococcus granulosus potassium voltage gated channel protein 0.0016 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0122 0.0266 0.0744
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0012 0.0554
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0173 0.048
Echinococcus multilocularis voltage dependent calcium channel 0.0016 0.0008 0.0008
Onchocerca volvulus 0.0072 0.0144 0.0832
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0098 0.0272
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0002 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0144 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0029 0.0077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0484
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0034 0.0096
Echinococcus granulosus transient receptor potential cation channel 0.0016 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0016 0.0008 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0135 0.9373
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Entamoeba histolytica hypothetical protein 0.0023 0.0025 0.0424
Loa Loa (eye worm) hypothetical protein 0.0071 0.0142 0.0396
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0002 0.0002
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0019 0.0183
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0065 0.1666
Brugia malayi hypothetical protein 0.0122 0.0266 0.074
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0019 0.0182
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0034 0.0096
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0056 0.0639
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0065 0.4347
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0016 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0071
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0017 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.0814 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0016 0.0008 0.0008
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0016 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0047
Echinococcus granulosus hypothetical protein 0.0014 0.0002 0.0005
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1064 0.2571 0.2571
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0048 0.3116
Plasmodium vivax hexose transporter 0.0105 0.0225 0.2076
Echinococcus multilocularis transient receptor potential cation channel 0.0016 0.0008 0.0008
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0056 0.0156
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0019 0.0135
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.0056 0.0487
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0098 1
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0047 0.0606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0019 0.0135
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0048 0.3116
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0019 0.0135
Echinococcus granulosus tar DNA binding protein 0.0064 0.0124 0.0348
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0144 0.1285
Brugia malayi MH2 domain containing protein 0.0025 0.0029 0.0077
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0056 0.0056
Brugia malayi Sugar transporter family protein 0.0015 0.0004 0.0007
Brugia malayi major facilitator superfamily protein 0.0015 0.0004 0.0007
Mycobacterium tuberculosis Conserved protein 0.0072 0.0144 0.1285
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Onchocerca volvulus 0.0015 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus granulosus intermediate filament protein 0.0027 0.0034 0.0096
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0016 0.0008 0.0017
Onchocerca volvulus 0.0021 0.0019 0.0101
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0019 0.1054
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0065 0.0177
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0002 0.0005
Loa Loa (eye worm) ctsf protein 0.0018 0.0012 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0053
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0016 0.0008 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0135 0.9373
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.003 0.0041 0.0109
Brugia malayi jmjC domain containing protein 0.0099 0.021 0.0584
Brugia malayi hypothetical protein 0.0015 0.0004 0.0007
Brugia malayi MH1 domain containing protein 0.0014 0.0002 0.0001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.026 0.0604 0.1688
Loa Loa (eye worm) hypothetical protein 0.0155 0.0347 0.097
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0026 0.0309
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0123 0.0338
Brugia malayi Bromodomain containing protein 0.0312 0.0732 0.204
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0029
Onchocerca volvulus 0.0018 0.0012 0.006
Loa Loa (eye worm) hypothetical protein 0.0294 0.0688 0.1922
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0058 0.3844
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0048 0.3116
Loa Loa (eye worm) hypothetical protein 0.0036 0.0056 0.0156
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0324 0.0324
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.0863 0.241
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0012 0.0096
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0025 0.0263
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0016 0.0008 0.0017
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0025 0.0263
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0045 0.0358
Loa Loa (eye worm) oxidoreductase 0.0021 0.0019 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0002 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0002 0.0002
Brugia malayi cation channel family protein 0.0016 0.0008 0.0017
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0019 0.0211
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Schistosoma mansoni voltage-gated cation channel 0.0016 0.0008 0.0017
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0026 0.0199
Onchocerca volvulus 0.0018 0.0012 0.006
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0004 0.0005
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0047 0.0606
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0019 0.0135
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0016 0.0008 0.0259
Onchocerca volvulus 0.0084 0.0173 0.1003
Loa Loa (eye worm) hypothetical protein 0.0071 0.0141 0.0395
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0019 0.0183
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0302 0.0839
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0002 0.0002
Leishmania major glucose transporter, lmgt3 0.0033 0.0048 0.3116
Echinococcus granulosus short transient receptor potential channel 6 0.0139 0.0308 0.0861
Echinococcus granulosus peregrin 0.004 0.0066 0.0185
Echinococcus multilocularis neuropeptide receptor A26 0.0964 0.2327 0.2327
Onchocerca volvulus 0.0021 0.0019 0.0101
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.0863 0.241
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0042 0.0042
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.003 0.0041 0.0041
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0051 0.0094 0.1281
Loa Loa (eye worm) hypothetical protein 0.0032 0.0045 0.0126
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.3116
Trichomonas vaginalis esterase, putative 0.0072 0.0144 0.1726
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0019 0.0135
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0016 0.0008 0.0017
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0058 0.3844
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0148 0.033 0.0918
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0012 0.0096
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0019 0.0183
Echinococcus granulosus transient receptor potential cation channel 0.0016 0.0008 0.0022
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0016 0.0008 0.0022
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0016 0.0008 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0096
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0141 0.1571
Onchocerca volvulus 0.0015 0.0004 0.0015
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0051 0.0094 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0071 0.0142 0.0391
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0141 0.1571
Schistosoma mansoni smad1 5 8 and 0.0025 0.0029 0.0077
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0002 0.0005
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.0225 0.0629
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.0324 0.0902
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0344 0.081 0.7405
Echinococcus multilocularis peregrin 0.004 0.0066 0.0066
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0012 0.0012
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0002 0.0005
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0048 0.0538
Echinococcus granulosus voltage gated potassium channel 0.0016 0.0008 0.0022
Brugia malayi beta-lactamase 0.0072 0.0144 0.0398
Schistosoma mansoni microtubule-associated protein tau 0.0696 0.1672 0.4668
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0141 0.1702
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0016 0.0008 0.0022
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0017 0.205
Echinococcus granulosus potassium voltage gated channel protein 0.0016 0.0008 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0002 0.0002
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0002 0.0002
Schistosoma mansoni two-pore calcium channel 0.0016 0.0008 0.0017
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0016 0.0008 0.0017
Onchocerca volvulus 0.0018 0.0012 0.006
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0058 0.0505
Leishmania major hypothetical protein, conserved 0.0064 0.0124 0.8557
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0002 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0047 0.0047
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.0456 0.1271
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0019 0.0183
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0016 0.0008 0.0022
Echinococcus granulosus TRP transient receptor potential channel 0.0082 0.017 0.0474
Schistosoma mansoni ryanodine receptor related 0.0016 0.0008 0.0017
Loa Loa (eye worm) voltage-gated potassium channel 0.0016 0.0008 0.0022
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0047 0.0126
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0071 0.0142 0.0142
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0004 0.0007
Loa Loa (eye worm) voltage-dependent calcium channel 0.0016 0.0008 0.0022
Loa Loa (eye worm) cysteine protease 0.0018 0.0012 0.0033
Echinococcus granulosus methyl CpG binding domain protein 2 0.0071 0.0142 0.0396
Trypanosoma cruzi ISWI complex protein 0.0064 0.0124 0.8557
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0127 0.1526
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0127 0.0351
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0047 0.039
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0016 0.0008 0.0259
Echinococcus multilocularis expressed conserved protein 0.0135 0.0299 0.0299
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0025 0.0025
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.0456 0.1275
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0324 0.0324
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0042 0.0542
Loa Loa (eye worm) hypothetical protein 0.0344 0.081 0.2262
Echinococcus multilocularis transient receptor potential ion channel A 0.0189 0.043 0.043
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0144 0.1735
Schistosoma mansoni hypothetical protein 0.0502 0.1197 0.3342
Echinococcus granulosus transient receptor potential cation channel 0.0016 0.0008 0.0022
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0016 0.0008 0.0008
Echinococcus granulosus fetal alzheimer antigen falz 0.0094 0.0198 0.0552
Echinococcus multilocularis microtubule associated protein 2 0.0696 0.1672 0.1672
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0056 0.0152
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.0225 0.0225
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0047 0.0126
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0123 0.0123
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0019 0.0183
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0136 0.0302 0.0839
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0012 0.0096
Echinococcus granulosus subfamily M12B unassigned peptidase 0.003 0.0041 0.0113
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.0008 0.0008
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.0056 0.0741
Schistosoma mansoni hypothetical protein 0.0063 0.0123 0.0338
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Brugia malayi MH1 domain containing protein 0.0025 0.0029 0.0077
Echinococcus granulosus zinc finger protein 0.0081 0.0167 0.0468
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0002 0.0002
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0048 0.0538
Onchocerca volvulus 0.0015 0.0004 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0141 0.9809
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0064 0.0124 0.0342
Leishmania major protein kinase, putative 0.0036 0.0056 0.3705
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0016 0.0008 0.0022
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0048 0.3116
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0033
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0045 0.0506
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0019 0.0048
Onchocerca volvulus 0.0072 0.0144 0.0832
Echinococcus multilocularis GPCR, family 2 0.0063 0.0123 0.0123
Schistosoma mansoni transient receptor potential channel 0.0205 0.047 0.1309
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0016 0.0008 0.0022
Echinococcus granulosus voltage dependent calcium channel 0.0016 0.0008 0.0022
Loa Loa (eye worm) RecQ helicase 0.002 0.0017 0.0047
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0056 0.0156
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0047 0.013
Loa Loa (eye worm) hypothetical protein 0.0053 0.0098 0.0272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0135 0.9373
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Brugia malayi Matrixin family protein 0.0282 0.0659 0.1838
Onchocerca volvulus 0.0021 0.0019 0.0101
Echinococcus granulosus solute carrier family 22 0.0015 0.0004 0.0012
Echinococcus multilocularis solute carrier family 22 0.0015 0.0004 0.0004
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0016 0.0008 0.0008
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0047 0.3033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Loa Loa (eye worm) reprolysin 0.003 0.0041 0.0113
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0019 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0324 0.0902
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0051 0.0094 0.0842
Loa Loa (eye worm) ion channel NompC 0.0016 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0045 0.0126
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.0056 0.0741
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0063 0.0121 0.0339
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0029 0.0081
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0098 0.0877
Brugia malayi Cyclic-nucleotide gated cation channel 0.0016 0.0008 0.0017
Brugia malayi Matrixin family protein 0.0282 0.0659 0.1838
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0016 0.0008 0.0008
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0017 0.0047
Brugia malayi Matrixin family protein 0.0282 0.0659 0.1838
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0225 0.2726
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0016 0.0008 0.0008
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0002 0.0005
Echinococcus granulosus transient receptor potential cation channel 0.0016 0.0008 0.0022
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0019 0.0027
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0016 0.0008 0.0008
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0029 0.0029
Entamoeba histolytica recQ family helicase, putative 0.002 0.0017 0.0148
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0058 0.3844
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0016 0.0008 0.0045
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0042 0.0117
Schistosoma mansoni hypothetical protein 0.0063 0.0123 0.0338
Brugia malayi Cathepsin L-like precursor 0.0018 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0141 0.1261
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.009 0.0793
Brugia malayi Bromodomain containing protein 0.004 0.0066 0.018
Loa Loa (eye worm) matrixin family protein 0.072 0.173 0.4833
Brugia malayi Reprolysin 0.003 0.0041 0.0109
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0008 0.0017
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0016 0.0008 0.0259
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0002 0.0005
Trypanosoma brucei glucose transporter 2A 0.0033 0.0048 0.3116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0135 0.9373

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of human ERG channel ChEMBL. 19278250
AUC (ADMET) = 7476 hr.ng/ml AUC in C57BL/6 mouse at 30 mg/kg, po ChEMBL. 19278250
AUC (ADMET) = 249.2 ng.hr/ml/mg/kg AUC in C57BL/6 mouse at 30 mg/kg, po ChEMBL. 19725580
CL (ADMET) = 17.2 ml/min.kg Clearance in C57BL/6 mouse at 2 mg/kg, iv ChEMBL. 19278250
CL (ADMET) = 17.2 ml/min.kg Clearance in C57BL/6 mouse at 2 mg/kg, iv ChEMBL. 19725580
Cmax (ADMET) = 3084 ng/ml Cmax in C57BL/6 mouse at 30 mg/kg, po ChEMBL. 19278250
Cmax (ADMET) = 3084 ng/ml Cmax in C57BL/6 mouse at 30 mg/kg, po ChEMBL. 19725580
F (ADMET) = 27 % Oral bioavailability in C57BL/6 mouse at 30 mg/kg ChEMBL. 19278250
F (ADMET) = 27 % Oral bioavailability in C57BL/6 mouse at 30 mg/kg ChEMBL. 19725580
IC50 (binding) = 2 nM Inhibition of human recombinant MMP12 expressed in Escherichia coli ChEMBL. 19278250
IC50 (binding) = 2 nM Inhibition of human recombinant MMP12 ChEMBL. 19725580
IC50 (binding) > 5 nM Inhibition of human Aggrecanase-1 ChEMBL. 19278250
IC50 (binding) > 6 nM Inhibition of human MMP1 ChEMBL. 19278250
IC50 (binding) > 10 nM Inhibition of human Aggrecanase-2 ChEMBL. 19278250
IC50 (binding) > 22 nM Inhibition of human MMP7 ChEMBL. 19278250
IC50 (binding) > 25 nM Inhibition of human TACE ChEMBL. 19278250
IC50 (binding) = 60 nM Inhibition of MMP2 ChEMBL. 19725580
IC50 (binding) = 120 nM Inhibition of human recombinant MMP13 expressed in Escherichia coli ChEMBL. 19278250
IC50 (binding) = 120 nM Inhibition of human recombinant MMP13 ChEMBL. 19725580
IC50 (binding) = 160 nM Inhibition of mouse recombinant MMP12 ChEMBL. 19278250
IC50 (binding) = 320 nM Inhibition of rat MMP12 ChEMBL. 19278250
IC50 (binding) = 351 nM Inhibition of human MMP3 ChEMBL. 19278250
IC50 (binding) = 1100 nM Inhibition of human MMP14 ChEMBL. 19278250
IC50 (binding) = 1300 nM Inhibition of human MMP9 ChEMBL. 19278250
Inhibition (functional) > 50 % Inhibition of human recombinant MMP-12-induced lung inflammation in C57BL/6 mouse chronic obstructive pulmonary disease model assessed as inhibition of bronchoalveolar lavage fluid inflammation at 30 mg/kg, po qd ChEMBL. 19278250
Inhibition (functional) > 70 % Inhibition of human recombinant MMP-12-induced lung inflammation in C57BL/6 mouse chronic obstructive pulmonary disease model assessed as inhibition of bronchoalveolar lavage fluid macrophage level at 30 mg/kg, po qd ChEMBL. 19278250
MED (functional) = 5 mg kg-1 Inhibition of human recombinant MMP-12-induced lung inflammation in po dosed C57BL/6 mouse chronic obstructive pulmonary disease model assessed as inhibition of lung inflammation dosed twice daily ChEMBL. 19278250
T1/2 (ADMET) = 3 hr Half life in C57BL/6 mouse at 30 mg/kg, po ChEMBL. 19278250
T1/2 (ADMET) = 3 hr Half life in C57BL/6 mouse at 30 mg/kg, po ChEMBL. 19725580
Vdss (ADMET) = 1.9 L/Kg Volume of distribution at steady state in C57BL/6 mouse at 2 mg/kg, iv ChEMBL. 19278250
Vdss (ADMET) = 1.9 L/Kg Volume of distribution at steady state in C57BL/6 mouse at 2 mg/kg, iv ChEMBL. 19725580

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.