Detailed information for compound 1257528

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 343.379 | Formula: C21H17N3O2
  • H donors: 2 H acceptors: 3 LogP: 1.95 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCc1ccccc1c1cccc(c1)c1cc(=O)n(c2c1cccn2)O
  • InChi: 1S/C21H17N3O2/c22-13-16-5-1-2-8-17(16)14-6-3-7-15(11-14)19-12-20(25)24(26)21-18(19)9-4-10-23-21/h1-12,26H,13,22H2
  • InChiKey: XNCQHZOIZVMEPA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Reverse transcriptase Starlite/ChEMBL References
Human immunodeficiency virus 1 Integrase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 208 aa 26.4 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 222 aa 22.5 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 227 aa 26.4 %
Trypanosoma congolense Retroviral aspartyl protease/Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative Reverse transcriptase   259 aa 237 aa 29.1 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 226 aa 24.3 %
Candida albicans hypothetical protein Reverse transcriptase   259 aa 223 aa 29.1 %
Candida albicans polyprotein of retrotransposon Tca8 Reverse transcriptase   259 aa 238 aa 26.5 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 245 aa 25.7 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 227 aa 26.4 %
Candida albicans ReverseTranscriptase similar to fruit fly Tom element Reverse transcriptase   259 aa 244 aa 27.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0425 0.0562
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0039 0.0231 0.1673
Toxoplasma gondii hypothetical protein 0.0031 0.0136 0.1532
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0315 0.2295
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0217 0.0287
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0066 0.0066
Brugia malayi hypothetical protein 0.0026 0.0066 0.0088
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0021 0.0005 0.0074
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0026 0.0065 0.013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Loa Loa (eye worm) hypothetical protein 0.0054 0.0413 0.0545
Brugia malayi Dopamine receptor 0.0026 0.0066 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0169 0.0596
Entamoeba histolytica P-glycoprotein-5 0.0039 0.023 0.3211
Trypanosoma brucei multidrug resistance protein E 0.0039 0.0231 0.0669
Schistosoma mansoni single-minded 0.0098 0.0971 0.1839
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0344 0.2515
Schistosoma mansoni coup transcription factor 0.0147 0.157 0.2973
Brugia malayi Matrixin family protein 0.0115 0.1181 0.156
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.0028 0.0028
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0066 0.0126
Brugia malayi hypothetical protein 0.0031 0.0136 0.0179
Echinococcus granulosus sex peptide receptor 0.0026 0.0066 0.0134
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0117 0.1197 0.1581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0315 0.1127
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0055 0.0429 0.0566
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0147 0.157 0.2973
Brugia malayi Cathepsin L-like precursor 0.0034 0.0168 0.0222
Onchocerca volvulus 0.0069 0.0607 0.2071
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.071 0.0937
Loa Loa (eye worm) hypothetical protein 0.0078 0.0715 0.0945
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0089 0.0856 0.0856
Brugia malayi ecdysteroid receptor 0.0147 0.157 0.2074
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0315 0.0634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1353 0.4
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0715 0.2588
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0325 0.0654
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0029 0.0105 0.0737
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0168 0.0318
Loa Loa (eye worm) hypothetical protein 0.0039 0.023 0.0303
Echinococcus granulosus neuropeptide receptor 0.0026 0.0066 0.0134
Onchocerca volvulus 0.0031 0.0136 0.0463
Brugia malayi Matrixin family protein 0.0115 0.1181 0.156
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0039 0.023 0.2639
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0039 0.0231 0.1673
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0029 0.0108 0.0218
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.014 0.1494 0.1973
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0066 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0053 0.0173
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0038 0.0217 0.0287
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0136 0.0257
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Brugia malayi Thioredoxin reductase 0.0048 0.0344 0.0455
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0067 0.0581 0.8128
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0147 0.157 0.2074
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.2386 0.3151
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0168 0.1913
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0066 0.0134
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0147 0.157 0.3163
Schistosoma mansoni nAChR subunit 0.0038 0.0217 0.0411
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Brugia malayi E1-E2 ATPase family protein 0.0043 0.0283 0.0374
Trypanosoma cruzi P-type H+-ATPase, putative 0.0042 0.0268 0.1953
Mycobacterium leprae PROBABLE HYDROLASE 0.014 0.1494 0.6088
Loa Loa (eye worm) hypothetical protein 0.0077 0.071 0.0937
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0715 0.0715
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0147 0.157 0.5361
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0076 0.0692 0.131
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0168 0.2348
Onchocerca volvulus 0.0026 0.0066 0.0227
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0391 0.2859
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Leishmania major cathepsin L-like protease 0.0034 0.0168 0.1207
Onchocerca volvulus 0.0031 0.0136 0.0463
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0147 0.157 0.157
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0013
Trichomonas vaginalis cation-transporting ATPase, putative 0.0088 0.0841 0.3046
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.1325 0.267
Trichomonas vaginalis abcb9, putative 0.0039 0.023 0.0818
Loa Loa (eye worm) hypothetical protein 0.0184 0.2039 0.2693
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0066 0.0126
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0391 0.4531
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0325 0.0615
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0315 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0066 0.0134
Leishmania major P-type ATPase, putative 0.0054 0.0418 0.306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0325 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0065 0.0216
Onchocerca volvulus 0.0026 0.0066 0.0227
Loa Loa (eye worm) hypothetical protein 0.0154 0.1657 0.2188
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0381 0.2789
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0066 0.0227
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.4876 0.4876
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0168 0.1207
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0039 0.023 0.023
Trichomonas vaginalis set domain proteins, putative 0.0241 0.2749 1
Loa Loa (eye worm) hypothetical protein 0.0629 0.7572 1
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0094 0.092 0.374
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0136 0.1532
Schistosoma mansoni biogenic amine receptor 0.0026 0.0066 0.0126
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0169 0.1843 0.1843
Loa Loa (eye worm) norepinephrine transporter 0.0184 0.2039 0.2693
Loa Loa (eye worm) hypothetical protein 0.007 0.0621 0.082
Echinococcus granulosus nuclear receptor nhr 48 0.0069 0.0607 0.1222
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0066 0.0134
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0078 0.0715 0.1355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0168 0.0593
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0066 0.0567 0.5462
Loa Loa (eye worm) hypothetical protein 0.0088 0.0841 0.1111
Brugia malayi MAP kinase sur-1 0.0052 0.0391 0.0516
Echinococcus multilocularis multidrug resistance protein 1 0.0039 0.023 0.023
Echinococcus granulosus multidrug resistance protein 1 0.0039 0.023 0.0463
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0377 0.0497
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0066 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0066 0.0066
Onchocerca volvulus 0.0034 0.0168 0.0574
Echinococcus granulosus cathepsin l1 0.0023 0.0029 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0325 0.0615
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0136 0.1532
Brugia malayi Hemopexin family protein 0.0164 0.1781 0.2352
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.1262 0.5141
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0217 0.0217
Schistosoma mansoni hypothetical protein 0.0026 0.0066 0.0126
Trichomonas vaginalis abcb9, putative 0.0039 0.023 0.0818
Toxoplasma gondii P-type ATPase PMA1 0.0042 0.0268 0.3095
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0065 0.0216
Trypanosoma cruzi P-type H+-ATPase, putative 0.0042 0.0268 0.1953
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Onchocerca volvulus 0.0034 0.0168 0.0574
Echinococcus granulosus FTZ F1 alpha 0.0147 0.157 0.3163
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0108 0.0143
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0217 0.0287
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0038 0.0217 0.0217
Mycobacterium tuberculosis Probable reductase 0.011 0.111 0.4519
Echinococcus multilocularis serotonin transporter 0.0184 0.2039 0.2039
Echinococcus granulosus lamin 0.0055 0.0425 0.0857
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0168 0.0593
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Schistosoma mansoni opsin-like receptor 0.0026 0.0066 0.0126
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0217 0.0217
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0217 0.0287
Onchocerca volvulus 0.0026 0.0066 0.0227
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0069 0.0607 0.0801
Entamoeba histolytica ATP-binding cassette protein, putative 0.0039 0.0231 0.3226
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0066 0.0126
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0419 0.4963 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0031 0.0136 0.0536
Entamoeba histolytica ATP-binding cassette protein, putative 0.0039 0.0231 0.3226
Entamoeba histolytica multidrug resistance protein, putative 0.0039 0.0231 0.3226
Echinococcus granulosus ubiquitin specific protease 41 0.0078 0.0715 0.1441
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0066 0.0126
Brugia malayi hypothetical protein 0.0026 0.0066 0.0088
Trypanosoma brucei p-glycoprotein 0.0039 0.0231 0.0669
Brugia malayi Nuclear hormone receptor E75 0.0069 0.0607 0.0801
Schistosoma mansoni sodium/chloride dependent transporter 0.0032 0.0141 0.0268
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Trypanosoma cruzi hypothetical protein 0.0022 0.0022 0.0125
Trypanosoma brucei trypanothione reductase 0.0048 0.0344 0.1006
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0136 0.0179
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0066 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1353 0.4
Brugia malayi hypothetical protein 0.0026 0.0066 0.0088
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.0143
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0038 0.0217 0.0411
Echinococcus granulosus death domain containing protein 0.0029 0.0108 0.0218
Schistosoma mansoni polycystin 1-related 0.006 0.0497 0.0942
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0149 0.1601 0.1601
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0391 0.1143
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0021 0.0005 0.0007
Brugia malayi Dopamine receptor protein 2 0.0026 0.0066 0.0088
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0315 0.2295
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0217 0.0438
Onchocerca volvulus 0.0184 0.2039 0.6964
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0652 0.1235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0168 0.0593
Echinococcus granulosus multidrug resistance associated protein 7 0.0039 0.0231 0.0465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0086 0.0294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1353 0.4
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Brugia malayi glutathione reductase 0.0048 0.0344 0.0455
Trichomonas vaginalis ABC transporter, putative 0.0039 0.023 0.0818
Mycobacterium ulcerans hydrolase 0.014 0.1494 0.6122
Echinococcus granulosus somatostatin receptor 0.0026 0.0066 0.0134
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0029 0.0105 0.1168
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0344 0.0694
Onchocerca volvulus 0.0154 0.1657 0.5658
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0168 0.0593
Loa Loa (eye worm) follicle stimulating hormone receptor 0.026 0.2975 0.3929
Brugia malayi nuclear receptor RXR 0.0077 0.071 0.0937
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0132 0.0249
Onchocerca volvulus 0.0038 0.0217 0.0742
Brugia malayi Cathepsin L-like precursor 0.0023 0.0029 0.0038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Plasmodium falciparum multidrug resistance protein 1 0.0039 0.023 0.2639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Trypanosoma cruzi cruzipain precursor, putative 0.0129 0.1353 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0077 0.071 0.0937
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0066 0.0134
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0038 0.0217 0.0217
Brugia malayi neuropeptide F receptor 0.0026 0.0066 0.0088
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0065 0.0065
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0066 0.0567 0.4168
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0054 0.0418 0.306
Onchocerca volvulus 0.0026 0.0066 0.0227
Schistosoma mansoni nAChR subunit 0.0038 0.0217 0.0411
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0168 0.0222
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.1353 1
Loa Loa (eye worm) matrix metalloproteinase 0.0115 0.1181 0.156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1353 0.4
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0132 0.0249
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0046 0.0319 0.2327
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0039 0.023 0.2639
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0039 0.023 0.0818
Onchocerca volvulus 0.0026 0.0066 0.0227
Schistosoma mansoni amine GPCR 0.0026 0.0066 0.0126
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0066 0.0066
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0217 0.0411
Leishmania major cathepsin L-like protease 0.0129 0.1353 1
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0065 0.0216
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0066 0.0066
Brugia malayi hypothetical protein 0.0026 0.0066 0.0088
Brugia malayi larval opioid receptor 0.0026 0.0066 0.0088
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0039 0.023 0.0818
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Echinococcus granulosus cation transporting atpase worm 0.0021 0.0005 0.0011
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0715 0.5269
Echinococcus multilocularis lamin dm0 0.0055 0.0425 0.0425
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0066 0.0567 0.7925
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0028 0.0057
Brugia malayi hypothetical protein 0.0026 0.0066 0.0088
Trichomonas vaginalis ABC transporter, putative 0.0039 0.023 0.0818
Echinococcus granulosus dnaJ subfamily B 0.0412 0.4876 0.9824
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0039 0.023 0.023
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0066 0.0567 0.7925
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0031 0.0136 0.0179
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0136 0.0179
Entamoeba histolytica P-glycoprotein-2, putative 0.0039 0.023 0.3211
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0021 0.0005 0.0074
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0066 0.0066
Onchocerca volvulus Matrix metalloproteinase homolog 0.0256 0.2929 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0066 0.0088
Trypanosoma brucei calcium-transporting ATPase, putative 0.0033 0.0154 0.0443
Brugia malayi nuclear hormone receptor 0.0069 0.0607 0.0801
Entamoeba histolytica ATP-binding cassette protein, putative 0.0039 0.0231 0.3226
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1256 0.1659
Loa Loa (eye worm) hypothetical protein 0.0039 0.0231 0.0305
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0066 0.0126
Brugia malayi Cathepsin L-like precursor 0.0023 0.0029 0.0038
Brugia malayi hypothetical protein 0.0051 0.0381 0.0503
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0168 0.0574
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0038 0.0223 0.3119
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0066 0.0126
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0391 0.0787
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0147 0.157 0.2973
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0103 0.1034 0.1034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0381 0.2789
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0217 0.0287
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0066 0.0066
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0136 0.0136
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0038 0.0217 0.0411
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0038 0.0217 0.0287
Leishmania major cathepsin L-like protease 0.0034 0.0168 0.1207
Loa Loa (eye worm) nuclear hormone receptor 0.0069 0.0607 0.0801
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0169 0.0596
Plasmodium falciparum amino acid transporter, putative 0.0031 0.0136 0.1532
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0038 0.0222 0.0448
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0039 0.023 0.0818
Echinococcus multilocularis copper transporting ATPase 1 0.0021 0.0005 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0607 0.1222
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0381 0.442
Echinococcus multilocularis nuclear receptor nhr 48 0.0069 0.0607 0.0607
Brugia malayi hypothetical protein 0.0073 0.0652 0.0862
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0039 0.023 0.0818
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0115 0.1181 0.2236
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0067 0.0581 0.21
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0066 0.0126
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0217 0.0217
Leishmania major hypothetical protein, conserved 0.0051 0.0381 0.2789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0315 0.1127
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0381 0.442
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0039 0.0231 0.0669
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0381 0.442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.071 0.0937
Brugia malayi PAS domain containing protein 0.0098 0.0971 0.1283
Loa Loa (eye worm) DR-78 0.0069 0.0607 0.0801
Onchocerca volvulus 0.0026 0.0066 0.0227
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0053 0.0174
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0076 0.0692 0.131
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0136 0.0257
Loa Loa (eye worm) hypothetical protein 0.0038 0.0222 0.0294
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0066 0.0088
Schistosoma mansoni lamin 0.0055 0.0425 0.0806
Brugia malayi hypothetical protein 0.0026 0.0066 0.0088
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0071 0.0484
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0136 0.0257
Toxoplasma gondii hypothetical protein 0.0031 0.0136 0.1532
Echinococcus granulosus cation transporting ATPase 13A1 0.0021 0.0005 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0325 0.0429
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0066 0.0066
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0077 0.071 0.1344
Brugia malayi tailless protein 0.0069 0.0607 0.0801
Brugia malayi Nuclear hormone receptor-like 1 0.0147 0.157 0.2074
Brugia malayi GnHR receptor homolog 0.0026 0.0066 0.0088
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0054 0.0418 0.0791
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0147 0.157 0.2074
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0078 0.0715 0.0945
Schistosoma mansoni hypothetical protein 0.0026 0.0066 0.0126
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0039 0.023 0.0818
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0147 0.157 0.3163
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0168 0.0222
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0098
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0217 0.245 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Echinococcus multilocularis ecdysone induced protein 78C 0.0147 0.157 0.157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0169 0.0596
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0066 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0315 0.1127
Onchocerca volvulus 0.0026 0.0066 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0147 0.157 0.2074
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0069 0.0607 0.2071
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0066 0.0126
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.014 0.1494 0.6088
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0255 0.1022
Onchocerca volvulus 0.0115 0.1181 0.4033
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0029 0.0054
Mycobacterium ulcerans DNA polymerase III subunit alpha 0.0216 0.2437 1
Leishmania major calcium-translocating P-type ATPase 0.0088 0.0841 0.6201
Schistosoma mansoni amine GPCR 0.0026 0.0066 0.0126
Brugia malayi Na,K-ATPase alpha subunit 0.0117 0.1197 0.1581
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0147 0.157 0.2074
Loa Loa (eye worm) hypoxia-induced factor 1 0.0305 0.3538 0.4673
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0066 0.0088
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0217 0.0438
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0031 0.0136 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0169 0.0596
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0077 0.071 0.143
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0089 0.0856 0.3497
Onchocerca volvulus 0.0164 0.1781 0.608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0147 0.157 0.2074
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Brugia malayi Pre-SET motif family protein 0.0212 0.2386 0.3151
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0029 0.0108 0.0108
Loa Loa (eye worm) steroid hormone receptor 0.0147 0.157 0.2074
Schistosoma mansoni netrin receptor unc5 0.0029 0.0108 0.0205
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0524 0.0992
Loa Loa (eye worm) hypothetical protein 0.0031 0.0136 0.0179
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0715 0.0715
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0039 0.023 0.1665
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0066 0.0134
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Loa Loa (eye worm) fibroinase 0.0034 0.0168 0.0222
Onchocerca volvulus 0.0026 0.0065 0.0221
Onchocerca volvulus Matrilysin homolog 0.0256 0.2929 1
Schistosoma mansoni nAChR subunit 0.0038 0.0217 0.0411
Entamoeba histolytica P-glycoprotein-2 0.0039 0.023 0.3211
Brugia malayi bHLH-PAS transcription factor 0.0073 0.0653 0.0862
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0168 0.0593
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0066 0.0126
Onchocerca volvulus 0.0026 0.0066 0.0227
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0103 0.1034 0.1957
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0065 0.0085
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0066 0.0088
Trichomonas vaginalis cation-transporting ATPase, putative 0.0042 0.0268 0.0959
Echinococcus multilocularis ubiquitin specific protease 41 0.0078 0.0715 0.0715
Entamoeba histolytica hypothetical protein 0.0073 0.0652 0.9119
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0066 0.0088
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0039 0.023 0.0818
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0147 0.157 0.157
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0315 0.0918
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0066 0.0126
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0065 0.0441
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0066 0.0066
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0066 0.0134
Schistosoma mansoni myosin xvIII 0.0026 0.0066 0.0126
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0078 0.0715 0.1355
Loa Loa (eye worm) hypothetical protein 0.0043 0.0284 0.0375
Echinococcus granulosus neuropeptide receptor 0.0026 0.0066 0.0134
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0039 0.023 0.0818
Loa Loa (eye worm) hypothetical protein 0.0147 0.157 0.2074
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0217 0.0287
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0442 0.5141
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0391 0.0787
Giardia lamblia Multidrug resistance-associated protein 1 0.0038 0.0223 0.2122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0168 0.0593
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Echinococcus granulosus g protein coupled receptor 0.0026 0.0066 0.0134
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0687 0.8294 1
Plasmodium vivax vivapain-2 0.0034 0.0168 0.1913
Echinococcus granulosus multidrug resistance associated protein 4 0.0022 0.0022 0.0045
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0054 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0039 0.0231 0.0305
Onchocerca volvulus 0.0029 0.0106 0.0363
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0039 0.0231 0.0305
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0054 0.0418 0.1503
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Brugia malayi hypothetical protein 0.0154 0.1657 0.2188
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0038 0.0217 0.0287
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0066 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0115 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Brugia malayi Cation transporter family protein 0.0038 0.0217 0.0287
Trichomonas vaginalis abcb9, putative 0.0039 0.023 0.0818
Schistosoma mansoni ankyrin 23/unc44 0.0029 0.0108 0.0205
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0391 0.0391
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0147 0.157 0.2973
Schistosoma mansoni nuclear hormone receptor 0.0147 0.157 0.2973
Brugia malayi calcium ATPase 0.0029 0.0105 0.0138
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0168 0.0593
Loa Loa (eye worm) LGC-31 protein 0.0038 0.0217 0.0287
Leishmania major calcium motive p-type ATPase, putative 0.0054 0.0418 0.306
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0065 0.0216
Loa Loa (eye worm) hypothetical protein 0.0073 0.0661 0.0873
Brugia malayi Membrane calcium atpase protein 3 0.0054 0.0418 0.0552
Loa Loa (eye worm) hypothetical protein 0.0031 0.0136 0.0179
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0074 0.0074
Schistosoma mansoni copper ABC transporter ATPase 0.0021 0.0005 0.001
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0136 0.0273
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0066 0.0126
Brugia malayi conserved hypotetical protein 0.0069 0.0607 0.0801
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0039 0.023 0.0463
Schistosoma mansoni smdr2 0.0039 0.023 0.0435
Giardia lamblia Multidrug resistance-associated protein 1 0.0039 0.0231 0.2193
Schistosoma mansoni hypothetical protein 0.0026 0.0066 0.0126
Leishmania major cathepsin L-like protease 0.0034 0.0168 0.1207
Leishmania major cathepsin L-like protease 0.0034 0.0168 0.1207
Entamoeba histolytica P-glycoprotein-2 0.0039 0.023 0.3211
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0039 0.023 0.0463
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0021 0.0005 0.0007
Onchocerca volvulus Netrin receptor homolog 0.0029 0.0108 0.037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0198 0.0703
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0217 0.0287
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0108 0.0143
Loa Loa (eye worm) hypothetical protein 0.0147 0.157 0.2074
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0066 0.0088
Schistosoma mansoni opsin-like receptor 0.0026 0.0066 0.0126
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0066 0.0088
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0136 0.0257
Brugia malayi neuropeptide F receptor 0.0026 0.0066 0.0088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0344 0.0455
Brugia malayi multidrug resistance related protein 1 0.0039 0.0231 0.0305
Echinococcus granulosus cathepsin l1 0.0034 0.0168 0.0338
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0077 0.071 0.071
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0071 0.0484
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0168 0.0574
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0045 0.0304 0.1221
Schistosoma mansoni multidrug resistance protein 0.0039 0.0231 0.0437
Brugia malayi hypothetical protein 0.033 0.3857 0.5093
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0715 0.1441
Schistosoma mansoni neuropeptide receptor 0.0026 0.0066 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0168 0.0593
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0066 0.0134
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0066 0.0126
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0391 0.1404
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0066 0.0126
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0045 0.0304 0.1227
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0038 0.0223 0.0295
Brugia malayi small heat shock protein 0.0629 0.7572 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0038 0.0217 0.0438
Schistosoma mansoni hypothetical protein 0.0023 0.0031 0.0059
Loa Loa (eye worm) hypothetical protein 0.0077 0.071 0.0937
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Brugia malayi AKH receptor 0.0026 0.0066 0.0088
Schistosoma mansoni histamine h1 receptor 0.0026 0.0066 0.0126
Brugia malayi Steroid receptor seven-up type 2 0.0147 0.157 0.2074
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0066 0.0088
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0391 0.1404
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0021 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1353 0.4
Onchocerca volvulus 0.0038 0.0217 0.0742
Onchocerca volvulus 0.0026 0.0066 0.0227
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Trypanosoma cruzi major cysteine proteinase, putative 0.0102 0.1009 0.7448
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0039 0.023 0.0818
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0038
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0066 0.0066
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0315 0.4397
Schistosoma mansoni nAChR subunit 0.0038 0.0217 0.0411
Loa Loa (eye worm) hypothetical protein 0.0184 0.2039 0.2693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0169 0.0596
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0066 0.0088
Trichomonas vaginalis ABC transporter, putative 0.0039 0.023 0.0818
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0136 0.0257
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0391 0.2859
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0022 0.002 0.0278
Echinococcus granulosus cpg binding protein 0.0031 0.0127 0.0256
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0066 0.0088
Brugia malayi E1-E2 ATPase family protein 0.0021 0.0005 0.0007
Loa Loa (eye worm) matrixin family protein 0.0256 0.2929 0.3868
Plasmodium vivax amine transporter, putative 0.0031 0.0136 0.1532
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0147 0.157 0.2074
Onchocerca volvulus 0.0038 0.0217 0.0742
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0066 0.0088
Brugia malayi hypoxia-induced factor 1 0.0305 0.3538 0.4673
Schistosoma mansoni cpg binding protein 0.0029 0.0106 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0089 0.0856 0.1724
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0217 0.0438
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0065 0.0441
Schistosoma mansoni multidrug resistance protein 0.0039 0.023 0.0435
Loa Loa (eye worm) hypothetical protein 0.005 0.0372 0.0491
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0066 0.0567 0.4168
Schistosoma mansoni cation-transporting ATPase 0.0021 0.0005 0.001
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0066 0.0567 0.2047
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0217 0.0287
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0039 0.023 0.0818
Brugia malayi nuclear receptor NHR-88 0.0069 0.0607 0.0801
Brugia malayi RE15519p 0.0026 0.0066 0.0088
Schistosoma mansoni thyroid hormone receptor 0.0273 0.3149 0.5962
Echinococcus granulosus nuclear factor of activated T cells 5 0.0149 0.1601 0.3226
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0147 0.157 0.3163
Echinococcus multilocularis geminin 0.0172 0.1889 0.1889
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0217 0.0287
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0066 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0147 0.157 0.2074
Trichomonas vaginalis cation-transporting ATPase, putative 0.0066 0.0567 0.2047
Echinococcus granulosus geminin 0.0172 0.1889 0.3806
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0391 0.1404
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0136 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0198 0.0703
Mycobacterium ulcerans hypothetical protein 0.0041 0.0255 0.1028
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0217 0.245 1
Loa Loa (eye worm) hypothetical protein 0.0447 0.5302 0.7002
Toxoplasma gondii thioredoxin reductase 0.0048 0.0344 0.3986
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0039 0.023 0.0818
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0445 0.5281 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0136 0.1532
Echinococcus granulosus orexin receptor type 2 0.0026 0.0066 0.0134
Onchocerca volvulus 0.0038 0.0217 0.0742
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0391 0.074
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0136 0.0179
Leishmania major calcium-transporting ATPase, putative 0.0054 0.0418 0.306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0086 0.0294
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0136 0.0257
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Schistosoma mansoni hypothetical protein 0.0164 0.1781 0.3372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1353 0.4
Schistosoma mansoni hypothetical protein 0.0172 0.1889 0.3577
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.0065 0.0244
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0136 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0053 0.0173
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0066 0.0134
Brugia malayi Death domain containing protein 0.0029 0.0108 0.0143
Echinococcus granulosus multidrug resistance associated protein 1 0.0039 0.0231 0.0465
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1256 0.1659
Echinococcus multilocularis cysteine protease 0.0034 0.0168 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0066 0.0126
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0007
Echinococcus multilocularis tumor protein p63 0.0343 0.4019 0.4019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Brugia malayi Uncoordinated protein 44 0.0029 0.0108 0.0143
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0217 0.0438
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0066 0.0066
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0066 0.0126
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0029 0.0038
Entamoeba histolytica hypothetical protein 0.0039 0.0231 0.3226
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0147 0.157 0.2074
Loa Loa (eye worm) hypothetical protein 0.005 0.0362 0.0478
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0066 0.0126
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0038 0.0217 0.0217
Schistosoma mansoni cpg binding protein 0.0031 0.0127 0.024
Brugia malayi Cathepsin L-like precursor 0.0034 0.0168 0.0222
Trypanosoma brucei protein kinase, putative 0.0052 0.0391 0.1143
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0217 0.0438
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0715 0.1441
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0039 0.023 0.0818
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0066 0.0066
Plasmodium vivax vivapain-2 0.0034 0.0168 0.1913
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0039 0.023 0.0818
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.0222
Echinococcus multilocularis nAChR subunit 0.0038 0.0217 0.0217
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0168 0.2348
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0147 0.157 0.2074
Schistosoma mansoni biogenic amine receptor 0.0026 0.0066 0.0126
Onchocerca volvulus 0.0026 0.0066 0.0227
Leishmania major protein kinase, putative 0.0026 0.0071 0.0484
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0078 0.0715 0.6906
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0066 0.0134
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0038 0.0217 0.0438
Schistosoma mansoni nuclear receptor 0.0069 0.0607 0.1149
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0066 0.0134
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0115 0.1183 0.4843
Giardia lamblia MRP-like ABC transporter 0.0039 0.0231 0.2193
Schistosoma mansoni hypothetical protein 0.0127 0.1325 0.2509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0086 0.0294
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0021 0.0005 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0066 0.0066
Brugia malayi Matrixin family protein 0.0115 0.1181 0.156
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0147 0.157 0.2074
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0022 0.002 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0066 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1353 0.4
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Brugia malayi Cathepsin L-like precursor 0.0034 0.0168 0.0222
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0184 0.2039 0.2693
Brugia malayi steroid hormone receptor 0.0147 0.157 0.2074
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0147 0.157 0.2074
Echinococcus granulosus Nuclear hormone receptor HR96 0.0069 0.0607 0.1222
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0147 0.157 0.2074
Echinococcus multilocularis serotonin receptor 0.0026 0.0066 0.0066
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0066 0.0066
Echinococcus granulosus tumor protein p63 0.0343 0.4019 0.8098
Schistosoma mansoni cpg binding protein 0.0031 0.0127 0.024
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0391 0.3747
Echinococcus granulosus intermediate filament protein 0.0055 0.0425 0.0857
Brugia malayi Matrixin family protein 0.0279 0.3215 0.4247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0127 0.0445
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0039 0.023 0.0923
Mycobacterium leprae Possible regulatory protein 0.0026 0.0065 0.0243
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.111 0.4519
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0038
Loa Loa (eye worm) hypothetical protein 0.0115 0.1181 0.156
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0066 0.0134
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0217 0.0438
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0038 0.0217 0.0287
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0054 0.0418 0.4849
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0066 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0217 0.0438
Onchocerca volvulus 0.005 0.0372 0.1269
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.111 0.4519
Loa Loa (eye worm) matrixin family protein 0.0279 0.3215 0.4247
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Brugia malayi excitatory GABA receptor EXP-1A 0.0038 0.0217 0.0287
Brugia malayi hypothetical protein 0.0077 0.071 0.0937
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Trypanosoma brucei P-type H+-ATPase, putative 0.0042 0.0268 0.0781
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0066 0.0134
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0325 0.0429
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0132 0.0132
Echinococcus granulosus Ankyrin 0.0029 0.0111 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Schistosoma mansoni hypothetical protein 0.0052 0.0395 0.0748
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0066 0.0134
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0168 0.1913
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0071 0.0484
Entamoeba histolytica ATP-binding cassette protein, putative 0.0039 0.0231 0.3226
Onchocerca volvulus 0.0034 0.0168 0.0574
Schistosoma mansoni amine GPCR 0.0026 0.0066 0.0126
Brugia malayi putative neuropeptide receptor 0.0026 0.0066 0.0088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Schistosoma mansoni nuclear receptor 0.0069 0.0607 0.1149
Schistosoma mansoni hypothetical protein 0.0073 0.0652 0.1235
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0217 0.0438
Entamoeba histolytica P-glycoprotein 5, putative 0.0039 0.023 0.3211
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0136 0.0179
Brugia malayi nuclear receptor NHR-67 0.0069 0.0607 0.0801
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0031 0.0136 0.0136
Echinococcus multilocularis cpg binding protein 0.0031 0.0127 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0132 0.0249
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0066 0.0134
Echinococcus granulosus Na:K ATPase alpha subunit 0.0103 0.1034 0.2083
Schistosoma mansoni nAChR subunit 0.0038 0.0217 0.0411
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0066 0.0066
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0066 0.0134
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0066 0.0567 0.4168
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0039 0.0231 0.1673
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0066 0.0066
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0039 0.023 0.023
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0095 0.0934 0.1234
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0039 0.023 0.023
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0199 0.0574
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0038 0.0217 0.0438
Leishmania major pentamidine resistance protein 1 0.0039 0.0231 0.1673
Echinococcus granulosus ecdysone induced protein 78C 0.0147 0.157 0.3163
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0066 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0231 0.0824
Loa Loa (eye worm) hypothetical protein 0.0039 0.023 0.0303
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0088 0.0841 0.6201
Onchocerca volvulus 0.0031 0.0136 0.0463
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0038 0.0217 0.0287
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.111 0.4519
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0054 0.0418 0.0418
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0039 0.023 0.0463
Onchocerca volvulus 0.0147 0.157 0.5361
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0065 0.0441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0029 0.0085
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Echinococcus multilocularis Ankyrin 0.0029 0.0111 0.0111
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0066 0.0066
Schistosoma mansoni cation-transporting atpase worm 0.0021 0.0005 0.001
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0069 0.0607 0.2071
Onchocerca volvulus 0.0026 0.0066 0.0227
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0315 0.2295
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0029 0.0105 0.0737
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0038 0.0217 0.0217
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0066 0.0066
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0095 0.0934 0.1234
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0147 0.157 0.2973
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0066 0.0066
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0069 0.0607 0.0607
Onchocerca volvulus 0.0034 0.0168 0.0574
Loa Loa (eye worm) E1-E2 ATPase 0.0042 0.0268 0.0355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1353 0.4
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0066 0.0134
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0168 0.0318
Leishmania major p-glycoprotein e 0.0039 0.0231 0.1673
Echinococcus granulosus copper transporting ATPase 1 0.0021 0.0005 0.0011
Echinococcus multilocularis transfer RNA-Lys 0.0073 0.0653 0.0653
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0169 0.1924
Brugia malayi Cation transporter family protein 0.0038 0.0217 0.0287
Brugia malayi hypothetical protein 0.0026 0.0066 0.0088
Mycobacterium leprae PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) 0.0217 0.245 1
Echinococcus granulosus single minded 2 0.0073 0.0653 0.1316
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0065 0.0216
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0028 0.0057
Schistosoma mansoni steroid hormone receptor ad4bp 0.0147 0.157 0.2973
Loa Loa (eye worm) hypothetical protein 0.0031 0.0136 0.0179
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0147 0.157 0.2973
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0066 0.0126
Trichomonas vaginalis taga, putative 0.0039 0.023 0.0818
Entamoeba histolytica ABC transporter, putative 0.0039 0.0231 0.3226
Leishmania major ABC-thiol transporter 0.0039 0.0231 0.1673
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0315 0.0415
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0295
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0217 0.0217
Schistosoma mansoni amine GPCR 0.0026 0.0066 0.0126
Onchocerca volvulus Protein ultraspiracle homolog 0.0147 0.157 0.5361
Schistosoma mansoni multidrug resistance protein 0.0039 0.023 0.0435
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0028 0.0084
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0377 0.0497
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0038 0.0217 0.0287
Loa Loa (eye worm) hypothetical protein 0.014 0.1494 0.1973
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0031 0.0136 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0053 0.0174
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0021 0.0005 0.001
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0199 0.1435
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0066 0.0126
Echinococcus multilocularis cation transporting ATPase 13A3 0.0021 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0147 0.157 0.2074
Schistosoma mansoni hypothetical protein 0.0172 0.1889 0.3577
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0065 0.0216
Echinococcus granulosus multidrug resistance protein 1 0.0039 0.023 0.0463
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0217 0.0287
Loa Loa (eye worm) hypothetical protein 0.0117 0.1197 0.1581
Brugia malayi nuclear receptor RXR 0.0069 0.0607 0.0801
Brugia malayi Melatonin receptor type 1A 0.0026 0.0066 0.0088
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0066 0.0567 0.6605
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0391 0.1404
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0147 0.157 0.2973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0053 0.0174
Schistosoma mansoni aryl hydrocarbon receptor 0.0098 0.0971 0.1839
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.111 0.4519
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Loa Loa (eye worm) hypothetical protein 0.0031 0.0136 0.0179
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Schistosoma mansoni opsin-like receptor 0.0026 0.0066 0.0126
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0038 0.0217 0.0287
Onchocerca volvulus 0.0026 0.0066 0.0227
Echinococcus granulosus g protein coupled receptor 0.0026 0.0066 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0147 0.157 0.2074
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0033 0.0154 0.1107
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0039 0.023 0.0303
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0217 0.0217
Echinococcus granulosus calcium transporting atpase 0.0076 0.0692 0.1394
Brugia malayi hypothetical protein 0.0026 0.0066 0.0088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0652 0.1315
Schistosoma mansoni ATPase 0.0088 0.0841 0.1593
Echinococcus granulosus nAChR subunit 0.0038 0.0217 0.0438
Loa Loa (eye worm) hypothetical protein 0.0031 0.0136 0.0179
Brugia malayi hypothetical protein 0.0026 0.0066 0.0088
Leishmania major cathepsin L-like protease 0.0129 0.1353 1
Brugia malayi hypothetical protein 0.0026 0.0066 0.0088
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0184 0.2039 0.3862
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0315 0.0918
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0066 0.0088
Schistosoma mansoni amine GPCR 0.0026 0.0066 0.0126
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0031 0.0136 0.0273
Entamoeba histolytica cysteine protease, putative 0.0034 0.0168 0.2348
Brugia malayi Dopamine receptor protein 1 0.0026 0.0066 0.0088
Entamoeba histolytica hypothetical protein 0.0073 0.0652 0.9119
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0066 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0147 0.157 0.2074
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0031 0.0136 0.0273
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0038 0.0217 0.0411
Echinococcus multilocularis multidrug resistance associated protein 1 0.0039 0.0231 0.0231
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0217 0.0217
Entamoeba histolytica P-glycoprotein-1 0.0039 0.023 0.3211
Echinococcus granulosus thyroid hormone receptor alpha 0.0069 0.0607 0.1222
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0168 0.0168
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0066 0.0126
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0168 0.0168
Mycobacterium ulcerans error-prone DNA polymerase 0.0216 0.2437 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Echinococcus granulosus g protein coupled receptor 0.0026 0.0066 0.0134
Trypanosoma brucei calcium-translocating P-type ATPase 0.0076 0.0692 0.2037
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0066 0.0567 0.1667
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0066 0.0066
Echinococcus multilocularis multidrug resistance protein 1 0.0039 0.023 0.023
Schistosoma mansoni sodium-dependent amino acid transporter 0.0031 0.0136 0.0257
Schistosoma mansoni type V p-type atpase isoform 0.0021 0.0005 0.001
Plasmodium vivax calcium-transporting ATPase, putative 0.0089 0.0856 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.157 0.2074
Brugia malayi sulfakinin receptor protein 0.0026 0.0066 0.0088
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0089 0.0856 1
Brugia malayi Cation transporter family protein 0.0038 0.0217 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0132 0.0249
Loa Loa (eye worm) multidrug resistance protein 3 0.0039 0.023 0.0303
Brugia malayi Serotonin receptor 0.0026 0.0066 0.0088
Trypanosoma brucei RNA helicase, putative 0.0292 0.3375 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0066 0.0126
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Schistosoma mansoni hypothetical protein 0.0029 0.0108 0.0205
Loa Loa (eye worm) hypothetical protein 0.0077 0.071 0.0937
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0085
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0234
Onchocerca volvulus 0.0026 0.0066 0.0227
Loa Loa (eye worm) cysteine protease 0.0034 0.0168 0.0222
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0652 0.0652
Leishmania major protein kinase, putative 0.0026 0.0071 0.0484
Onchocerca volvulus 0.0026 0.0066 0.0227
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0136 0.0136
Loa Loa (eye worm) glutathione reductase 0.0048 0.0344 0.0455
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0066 0.0066
Echinococcus multilocularis sex peptide receptor 0.0026 0.0066 0.0066
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0381 0.442
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0039 0.0231 0.1673
Echinococcus multilocularis ATP binding cassette sub family B 0.0038 0.0222 0.0222
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0607 0.1149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0066 0.0134
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0066 0.0134
Onchocerca volvulus 0.0038 0.0217 0.0742
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0067 0.0581 0.1172
Onchocerca volvulus Bile acid receptor homolog 0.0147 0.157 0.5361
Plasmodium falciparum glutathione reductase 0.0048 0.0344 0.3986
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0391 0.2859
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0082 0.0281
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0168 0.0168
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.1353 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0344 0.1386
Echinococcus multilocularis serotonin receptor 0.0026 0.0066 0.0066
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.0217 0.0287
Brugia malayi Cathepsin L-like precursor 0.0034 0.0168 0.0222
Onchocerca volvulus 0.0069 0.0607 0.2071
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0147 0.157 0.157
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0136 0.0257
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0066 0.0134
Brugia malayi CXXC zinc finger family protein 0.0029 0.0106 0.0141
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0147 0.157 0.3163
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0066 0.0088
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0029 0.0111 0.0211
Onchocerca volvulus 0.0038 0.0217 0.0742
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0066 0.0567 0.2047
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0066 0.0066
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0054 0.0418 0.0791
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0054 0.0418 0.0841
Schistosoma mansoni nAChR subunit 0.0038 0.0217 0.0411
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0054 0.0418 0.0841
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0065 0.0216
Brugia malayi G-protein coupled receptor 0.0026 0.0066 0.0088
Brugia malayi hypothetical protein 0.0077 0.071 0.0937
Plasmodium vivax P-type ATPase4, putative 0.0089 0.0856 1
Brugia malayi ORL1-like opioid receptor 0.0026 0.0066 0.0088
Brugia malayi G-protein coupled receptor 0.0026 0.0066 0.0088
Loa Loa (eye worm) hypothetical protein 0.0147 0.157 0.2074
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0391 0.2859
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0039 0.023 0.0818
Toxoplasma gondii P-type ATPase4, putative 0.0067 0.0581 0.6776
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0039 0.023 0.0818
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0066 0.0066
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0074 0.0149
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.111 0.4519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0198 0.0703
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.1262 0.5141
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.1262 0.5141
Toxoplasma gondii cathepsin CPL 0.0034 0.0168 0.1913
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0021 0.0005 0.0074
Giardia lamblia GTOR 0.0046 0.0315 0.3007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.011 0.0221
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0246 0.2806 0.5654
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0391 0.2859
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0066 0.0567 0.4168
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0077 0.071 0.1344
Leishmania major trypanothione reductase 0.0048 0.0344 0.2515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0082 0.0281
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.111 0.4519
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0315 0.2295
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.1262 0.5141
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0066 0.0088
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0391 0.0516
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0066 0.0134
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Schistosoma mansoni nuclear receptor nhr-48 0.0069 0.0607 0.1149
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0039 0.023 0.0818
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0039 0.0231 0.1673
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0168 0.0338
Loa Loa (eye worm) serotonin transporter b 0.0184 0.2039 0.2693
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0065 0.0216
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0066 0.0134
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0039 0.023 0.0818
Loa Loa (eye worm) multidrug resistance-associated protein 0.0023 0.0029 0.0039
Loa Loa (eye worm) hypothetical protein 0.0031 0.0136 0.0179
Brugia malayi orphan nuclear receptor NR2E1 0.0069 0.0607 0.0801
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0132 0.1486
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0715 0.2588
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0069 0.0607 0.1149
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0325 0.0325
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0065 0.0216
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0391 0.2859
Onchocerca volvulus Putative nachr subunit 0.0038 0.0217 0.0742
Treponema pallidum DNA polymerase III subunit alpha 0.0216 0.2437 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0147 0.157 0.157
Loa Loa (eye worm) solute carrier family 6 member 4 0.0184 0.2039 0.2693
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0053 0.0403 0.3868
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0217 0.0411
Entamoeba histolytica hypothetical protein 0.0073 0.0652 0.9119
Echinococcus multilocularis cation transporting ATPase 13A1 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0038 0.0217 0.0287
Onchocerca volvulus 0.0026 0.0066 0.0227
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0054 0.0418 0.1224
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0147 0.157 0.2074
Chlamydia trachomatis DNA polymerase III subunit alpha 0.0216 0.2437 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0069 0.0607 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0169 0.0596
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0066 0.0134
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0715 0.2588
Brugia malayi hypothetical protein 0.0069 0.0607 0.0801
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0039 0.023 0.0818
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0038 0.0217 0.0287
Loa Loa (eye worm) hypothetical protein 0.0147 0.157 0.2074
Trichomonas vaginalis ABC transporter, putative 0.0039 0.023 0.0818
Loa Loa (eye worm) hypothetical protein 0.0031 0.0136 0.0179
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0136 0.0273
Echinococcus granulosus allatostatin A receptor 0.0026 0.0066 0.0134
Schistosoma mansoni hypothetical protein 0.0412 0.4876 0.9232
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0147 0.157 0.2074
Schistosoma mansoni RAR-like nuclear receptor 0.0147 0.157 0.2973
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0026 0.0065 0.0216
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0066 0.0126
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0069 0.0607 0.1222
Leishmania major cathepsin L-like protease 0.0129 0.1353 1
Echinococcus multilocularis cysteine protease 0.0034 0.0168 0.0168
Brugia malayi cathepsin L-like precursor 0.0023 0.0029 0.0038
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0066 0.0066
Schistosoma mansoni multidrug resistance protein 0.0039 0.0231 0.0437
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0066 0.0227
Loa Loa (eye worm) hypothetical protein 0.0115 0.1181 0.156
Onchocerca volvulus 0.0023 0.0029 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0325 0.0615
Brugia malayi MH2 domain containing protein 0.0121 0.1256 0.1659
Echinococcus multilocularis cation transporting atpase worm 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0069 0.0607 0.0801
Schistosoma mansoni nAChR subunit 0.0038 0.0217 0.0411
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0199 0.1435
Schistosoma mansoni hypothetical protein 0.0026 0.0066 0.0126
Onchocerca volvulus 0.0034 0.0168 0.0574
Trichomonas vaginalis cation-transporting ATPase, putative 0.0088 0.0841 0.3046
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0419 0.4963 0.4963
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0071 0.0484
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0066 0.0088
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0038
Echinococcus granulosus fmrfamide receptor 0.0026 0.0066 0.0134
Schistosoma mansoni hypothetical protein 0.0035 0.0177 0.0336
Echinococcus granulosus cation transporting ATPase 13A3 0.0021 0.0005 0.0011
Schistosoma mansoni ATPase 0.0088 0.0841 0.1593
Loa Loa (eye worm) hypothetical protein 0.0031 0.0132 0.0174
Brugia malayi Pre-SET motif family protein 0.0031 0.0132 0.0174
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0168 0.0222
Echinococcus multilocularis lamin 0.0055 0.0425 0.0425
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0168 0.1207
Onchocerca volvulus 0.0055 0.0425 0.1453
Schistosoma mansoni neuropeptide receptor 0.0026 0.0066 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1353 0.4
Echinococcus multilocularis thyroid hormone receptor alpha 0.0273 0.3149 0.3149
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0168 0.0168
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.003 0.0119 0.1666
Brugia malayi Serotonin receptor 0.0026 0.0066 0.0088
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0066 0.0066
Onchocerca volvulus 0.0073 0.0653 0.223
Loa Loa (eye worm) hypothetical protein 0.0077 0.071 0.0937
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0031 0.0031
Schistosoma mansoni cation-transporting atpase worm 0.0021 0.0005 0.001
Giardia lamblia ABC transporter, putative 0.0039 0.0231 0.2193
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0136 0.0257
Treponema pallidum sodium- and chloride- dependent transporter 0.0184 0.2039 0.8366
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0147
Onchocerca volvulus Matrilysin homolog 0.0115 0.1181 0.4033
Brugia malayi nuclear receptor NHR-88 0.0147 0.157 0.2074
Echinococcus multilocularis multidrug resistance associated protein 4 0.0022 0.0022 0.0022
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0039 0.023 0.0818
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0066 0.0126
Plasmodium vivax multidrug resistance protein 1, putative 0.0039 0.023 0.2639
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0029 0.0105 0.0138
Onchocerca volvulus 0.0034 0.0168 0.0574
Loa Loa (eye worm) ctsf protein 0.0034 0.0168 0.0222
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0081
Brugia malayi G protein-coupled receptor 0.0026 0.0066 0.0088
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0054 0.0418 0.306
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0217 0.0217
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0066 0.0066
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0425 0.0562
Leishmania major P-type H -ATPase, putative 0.0042 0.0268 0.1953
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0088 0.0841 0.1695
Leishmania major P-type H -ATPase, putative 0.0042 0.0268 0.1953
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0069 0.0607 0.0607
Schistosoma mansoni sodium/chloride dependent transporter 0.0184 0.2039 0.3862
Onchocerca volvulus 0.0242 0.2752 0.9399
Loa Loa (eye worm) hypothetical protein 0.0147 0.157 0.2074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0168 0.0593
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0147 0.157 0.157
Echinococcus granulosus serotonin receptor 0.0026 0.0066 0.0134
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0067 0.0581 0.0581
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0066 0.0567 0.2047
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0037 0.0209 0.2916
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0066 0.0066
Brugia malayi Nuclear hormone receptor E75 0.0069 0.0607 0.0801
Echinococcus multilocularis musashi 0.0055 0.0425 0.0425
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.011 0.0145
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0065 0.0216
Plasmodium falciparum transporter, putative 0.0031 0.0136 0.1532
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0039 0.023 0.0818
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0029 0.0105 0.0138
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0095 0.0932 0.1764
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0039 0.023 0.0818
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0066 0.0088
Loa Loa (eye worm) hypothetical protein 0.0033 0.0154 0.0204
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0715 0.2107
Brugia malayi ABC transporter family protein 0.0039 0.023 0.0303
Onchocerca volvulus 0.0031 0.0132 0.0449
Entamoeba histolytica P-glyco protein 6, putative 0.0039 0.023 0.3211
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0069 0.0607 0.0801
Schistosoma mansoni intermediate filament proteins 0.0055 0.0425 0.0806
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0066 0.0567 0.1667
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0147 0.157 0.3163
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Giardia lamblia Multidrug resistance-associated protein 1 0.0039 0.0231 0.2193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0198 0.0703
Loa Loa (eye worm) hypothetical protein 0.033 0.3857 0.5093
Echinococcus granulosus serotonin transporter 0.0184 0.2039 0.4109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0147 0.157 0.2074
Schistosoma mansoni hypothetical protein 0.0292 0.3375 0.639
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Echinococcus multilocularis calcium transporting atpase 0.0076 0.0692 0.0692
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0607 0.1149
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0115 0.1181 0.156
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0088 0.0841 0.0841
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0066 0.0567 0.2047
Brugia malayi hypothetical protein 0.0033 0.0156 0.0206
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0038 0.0217 0.0438
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0381 0.1115
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0147 0.157 0.2074
Loa Loa (eye worm) hypothetical protein 0.0184 0.2039 0.2693
Schistosoma mansoni lamin 0.0055 0.0425 0.0806
Brugia malayi calcium ATPase 0.0025 0.0059 0.0078
Mycobacterium ulcerans putative regulatory protein 0.0073 0.0653 0.2664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0053 0.0174
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0029 0.0399
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0089 0.0856 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0425 0.0562
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.1325 0.1325
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0066 0.0066
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0315 0.0415
Onchocerca volvulus 0.0034 0.0168 0.0574
Onchocerca volvulus 0.0026 0.0066 0.0227
Echinococcus multilocularis multidrug resistance associated protein 7 0.0039 0.0231 0.0231
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0715 0.5269
Plasmodium vivax SET domain protein, putative 0.0031 0.0132 0.1486
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Trypanosoma brucei P-type H+-ATPase, putative 0.0042 0.0268 0.0781
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0069 0.0607 0.0607
Loa Loa (eye worm) hypothetical protein 0.0051 0.0381 0.0503
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0066 0.0088
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0217 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0015 0.0029
Echinococcus granulosus lamin dm0 0.0055 0.0425 0.0857
Brugia malayi Cathepsin L-like precursor 0.0034 0.0168 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Schistosoma mansoni retinoic acid receptor RXR 0.0246 0.2806 0.5314
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0076 0.0692 0.131
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0066 0.0134
Leishmania major p-glycoprotein 0.0039 0.023 0.1665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1353 0.4
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0217 0.0411
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0038 0.0217 0.0287
Schistosoma mansoni multidrug resistance protein 0.0039 0.023 0.0435
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0031 0.0062
Brugia malayi nuclear hormone receptor family member odr-7 0.0069 0.0607 0.0801
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0217 0.0287
Brugia malayi ecdysone receptor 0.0069 0.0607 0.0801
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.011 0.0145
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0039 0.023 0.0463
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0039 0.0231 0.0669
Trypanosoma cruzi multidrug resistance protein E, putative 0.0039 0.0231 0.1673
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0177 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0168 0.0593
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0168 0.0593
Onchocerca volvulus 0.0026 0.0066 0.0227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0066 0.0066
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0136 0.0179
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0039 0.023 0.0818
Echinococcus granulosus Nuclear hormone receptor HR96 0.0069 0.0607 0.1222
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0066 0.0134
Onchocerca volvulus 0.0039 0.023 0.0784
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0065 0.013
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0106 0.0141
Brugia malayi Matrixin family protein 0.0115 0.1181 0.156
Brugia malayi follicle stimulating hormone receptor 0.026 0.2975 0.3929
Loa Loa (eye worm) hypothetical protein 0.0147 0.157 0.2074
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0344 0.3986
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0066 0.0134
Brugia malayi hypothetical protein 0.0069 0.0607 0.0801
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0066 0.0567 0.2047
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0039 0.023 0.0918
Onchocerca volvulus 0.0055 0.0425 0.1453
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0377 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0169 0.0596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0039 0.023 0.023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0607 0.0607
Trypanosoma cruzi P-type H+-ATPase, putative 0.0029 0.0105 0.0737
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0038 0.0217 0.0438
Loa Loa (eye worm) hypothetical protein 0.0051 0.0377 0.0497
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0325 0.0325
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0066 0.0126
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0078 0.0715 0.5269
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0132 0.0265
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0066 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0066 0.0066
Echinococcus multilocularis FTZ F1 alpha 0.0147 0.157 0.157
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0066 0.0066
Schistosoma mansoni biogenic amine receptor 0.0026 0.0066 0.0126
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0066 0.0066
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0038 0.0217 0.0287
Brugia malayi intermediate filament protein 0.0055 0.0425 0.0562
Brugia malayi multidrug resistance protein 3 0.0039 0.023 0.0303
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0118 0.1214 0.8966
Schistosoma mansoni multidrug resistance protein 0.0039 0.0231 0.0437
Schistosoma mansoni neuropeptide receptor 0.0026 0.0066 0.0126
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.1353 1
Brugia malayi ABC transporter transmembrane region family protein 0.0039 0.0231 0.0305
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0066 0.0134
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0066 0.0134
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0066 0.0134
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0039 0.023 0.0818
Plasmodium vivax glutathione reductase, putative 0.0048 0.0344 0.3986
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0039 0.0231 0.1673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1353 0.4
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0136 0.0273
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0168 0.0574
Schistosoma mansoni multidrug resistance protein 0.0039 0.0231 0.0437
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0168 0.0338
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Echinococcus granulosus netrin receptor unc 5 0.0029 0.0108 0.0218
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0168 0.1913
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0076 0.0692 0.0914
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0088
Loa Loa (eye worm) hypothetical protein 0.0447 0.5302 0.7002
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0315 0.4397
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0039 0.0231 0.2652
Plasmodium falciparum thioredoxin reductase 0.0048 0.0344 0.3986
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0055 0.0429 0.0566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0198 0.0703
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0066 0.0134
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0147 0.157 0.2074
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0117 0.1197 0.2267
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0066 0.0134
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0147 0.157 0.3163
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0038 0.0217 0.0287
Plasmodium falciparum calcium-transporting ATPase 0.0076 0.0692 0.8073
Echinococcus granulosus multidrug resistance protein 1 0.0039 0.023 0.0463
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0147 0.157 0.157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0066 0.0126
Loa Loa (eye worm) nuclear receptor NHR-67 0.0069 0.0607 0.0801
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0217 0.0287
Schistosoma mansoni neuropeptide receptor 0.0026 0.0066 0.0126
Loa Loa (eye worm) calcium ATPase 0.0038 0.0223 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0029 0.0085
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0066 0.0126
Schistosoma mansoni adenoreceptor 0.0026 0.0066 0.0126
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0078 0.0715 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0066 0.0126
Onchocerca volvulus 0.0115 0.1183 0.4039
Leishmania major cathepsin L-like protease 0.0034 0.0168 0.1207
Schistosoma mansoni zinc finger protein 0.0069 0.0607 0.1149
Echinococcus multilocularis netrin receptor unc 5 0.0029 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0147 0.157 0.2074
Loa Loa (eye worm) hypothetical protein 0.0077 0.071 0.0937
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0372 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0053 0.0173
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0287
Brugia malayi Cathepsin L-like precursor 0.0034 0.0168 0.0222
Echinococcus granulosus hypothetical protein 0.0026 0.0066 0.0134
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0026 0.0065 0.0065
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0425 0.0562
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0103 0.1034 1
Echinococcus multilocularis somatostatin receptor 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0081
Brugia malayi Protein kinase domain containing protein 0.003 0.0114 0.0151
Brugia malayi photoreceptor-specific nuclear receptor 0.0147 0.157 0.2074
Schistosoma mansoni thyroid hormone receptor 0.0273 0.3149 0.5962
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0136 0.1532
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0066 0.0567 0.1667
Entamoeba histolytica hypothetical protein 0.0073 0.0652 0.9119
Brugia malayi nuclear hormone receptor 0.0147 0.157 0.2074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0168 0.0593
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0066 0.0567 0.7925

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.67 uM Inhibition of wild type HIV1 reverse transcriptase RNasH activity ChEMBL. 20869872
IC50 (binding) = 18 uM Inhibition of HIV1 integrase strand transfer activity ChEMBL. 20869872

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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