Detailed information for compound 1264797

Basic information

Technical information
  • TDR Targets ID: 1264797
  • Name: ethyl 4-methyl-2-[3-methyl-4-(3-methylphenyl) diazenyl-5-oxo-4H-pyrazol-1-yl]-1,3-thiazole- 5-carboxylate
  • MW: 385.44 | Formula: C18H19N5O3S
  • H donors: 0 H acceptors: 3 LogP: 4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1sc(nc1C)N1N=C(C(C1=O)N=Nc1cccc(c1)C)C
  • InChi: 1S/C18H19N5O3S/c1-5-26-17(25)15-12(4)19-18(27-15)23-16(24)14(11(3)22-23)21-20-13-8-6-7-10(2)9-13/h6-9,14H,5H2,1-4H3
  • InChiKey: VWWACEFJSDMIAT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl 4-methyl-2-[3-methyl-4-(3-methylphenyl)azo-5-oxo-4H-pyrazol-1-yl]thiazole-5-carboxylate
  • 4-methyl-2-[3-methyl-4-(3-methylphenyl)azo-5-oxo-4H-pyrazol-1-yl]-5-thiazolecarboxylic acid ethyl ester
  • 2-[5-keto-3-methyl-4-(3-methylphenyl)azo-4H-pyrazol-1-yl]-4-methyl-thiazole-5-carboxylic acid ethyl ester
  • MLS000704204
  • SMR000225430
  • ethyl 4-methyl-2-{3-methyl-4-[(3-methylphenyl)diazenyl]-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}-1,3-thiazole-5-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0393 0.1421
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0134 0.0437
Plasmodium falciparum importin beta, putative 0.003 0.0141 0.8247
Brugia malayi nuclear receptor NHR-67 0.0014 0.0045 0.0154
Loa Loa (eye worm) histone methyltransferase 0.0009 0.001 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0176 0.094
Entamoeba histolytica hypothetical protein 0.0073 0.0409 0.1399
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0158 0.0521
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.021 0.1124
Schistosoma mansoni hypothetical protein 0.0032 0.0158 0.0182
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0053 0.1297
Trypanosoma brucei glucosidase, putative 0.0041 0.021 0.5734
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0097 0.0309
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Schistosoma mansoni ferritin 0.0008 0.0007 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0146 0.0522
Trypanosoma brucei diacylglycerol kinase, putative 0.0018 0.0069 0.1764
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.005 0.0172
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.1949 0.6702
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0031 0.0146 0.0494
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0053 0.1297
Brugia malayi Ceramide kinase 0.0018 0.0069 0.0244
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0146 0.0522
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0045 0.0042
Onchocerca volvulus 0.0014 0.0045 0.0322
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0158 0.0155
Echinococcus multilocularis lamin 0.0027 0.012 0.0118
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.021 0.0239
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0092 0.2963
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0022 0.0022
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0361 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0134 0.0437
Echinococcus multilocularis musashi 0.0027 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0163
Schistosoma mansoni cpg binding protein 0.003 0.0144 0.0166
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.005 0.0256
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0045 0.0042
Trichomonas vaginalis ran, putative 0.0022 0.0092 0.0486
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0053 0.0051
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0059 0.3194
Brugia malayi diacylglycerol kinase 0.0018 0.0069 0.0244
Brugia malayi hypothetical protein 0.0011 0.0022 0.007
Plasmodium falciparum diacylglycerol kinase, putative 0.0018 0.0069 0.3833
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.017 0.568
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0009 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0231
Schistosoma mansoni diacylglycerol kinase theta 0.0018 0.0069 0.008
Echinococcus granulosus heat shock protein 0.0034 0.017 0.0193
Trypanosoma brucei heat shock protein, putative 0.0034 0.017 0.4602
Loa Loa (eye worm) hypothetical protein 0.0027 0.012 0.0407
Loa Loa (eye worm) hypothetical protein 0.0021 0.0088 0.0296
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.005 0.0256
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1848 1
Loa Loa (eye worm) endoplasmin 0.0034 0.017 0.0577
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.1848 0.6355
Schistosoma mansoni ras GTP exchange factor 0.0008 0.0002 0.0003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.001 0.0009
Brugia malayi heat shock protein 90 0.0034 0.017 0.0609
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0146 0.0166
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0168 0.4559
Brugia malayi Diacylglycerol kinase protein 2 0.0018 0.0069 0.0244
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0126 0.067
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0022 0.007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0035 0.0037
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0005 0.0005
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0022 0.0146
Echinococcus multilocularis pyruvate kinase 0.0033 0.0158 0.0156
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0126 0.067
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.005 0.1318
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0596 0.2159
Brugia malayi Smad1 0.0008 0.0005 0.0008
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0018 0.0069 0.1873
Trichomonas vaginalis bmru protein, putative 0.0018 0.0069 0.0364
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0146 0.109
Plasmodium falciparum heat shock protein 90 0.0034 0.017 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0146 0.0522
Schistosoma mansoni hypothetical protein 0.0032 0.0158 0.0182
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0053 0.0061
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0092 0.2501
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0045 0.0322
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.001 0.0008
Schistosoma mansoni sphingoid long chain base kinase 0.0472 0.2907 0.3352
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0007 0.0001
Brugia malayi MH2 domain containing protein 0.0008 0.0005 0.0008
Schistosoma mansoni pyruvate kinase 0.0017 0.0059 0.0068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0528 0.0607
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0146 0.0168
Brugia malayi steroid hormone receptor 0.0031 0.0146 0.0522
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0361 0.0358
Onchocerca volvulus Ceramide kinase 1 homolog 0.0018 0.0069 0.051
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Trypanosoma cruzi Sphingosine kinase 0.0018 0.0069 0.1873
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0011 0.0022 0.1218
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.021 0.0714
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0528 0.1912
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0168 0.9905
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1848 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1848 1
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0158 0.4275
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0092 0.009
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.01
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.017 0.4674
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0053 0.0184
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0171 0.4694
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0022 0.0019
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0158 0.4275
Entamoeba histolytica hypothetical protein 0.0073 0.0409 0.1399
Schistosoma mansoni hypothetical protein 0.007 0.0393 0.0453
Schistosoma mansoni endoplasmin 0.0034 0.017 0.0196
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0134 0.358
Echinococcus granulosus Diacylglycerol kinase zeta 0.0018 0.0069 0.0077
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.2504 0.2502
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0045 0.0154
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0053 0.0058
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0146 0.0144
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.017 0.4674
Leishmania major pyruvate kinase 0.0033 0.0158 0.4275
Mycobacterium ulcerans hypothetical protein 0.0029 0.0134 0.0437
Schistosoma mansoni alpha-glucosidase 0.0158 0.0945 0.109
Leishmania major glycosyl hydrolase-like protein 0.0015 0.005 0.1202
Brugia malayi Eye-specific diacylglycerol kinase 0.0018 0.0069 0.0244
Echinococcus granulosus transcription factor Dp 1 0.0038 0.019 0.0216
Echinococcus multilocularis expressed protein 0.0035 0.0176 0.0173
Schistosoma mansoni ran 0.0022 0.0092 0.0106
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0035 0.0032
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0045 0.0154
Mycobacterium ulcerans heat shock protein 90 0.0027 0.0126 0.041
Schistosoma mansoni ferritin 0.0008 0.0007 0.0008
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0022 0.0025
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0097 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0146 0.0522
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0018 0.0069 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.021 0.5791
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.1106 0.1103
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0168 0.0571
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.1106 0.1103
Brugia malayi ecdysone receptor 0.0014 0.0045 0.0154
Loa Loa (eye worm) hypothetical protein 0.0103 0.0596 0.2044
Schistosoma mansoni diacylglycerol kinase theta 0.0018 0.0069 0.008
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0007 0.0026
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0053 0.1297
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1848 1
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0043 0.004
Trypanosoma cruzi diacylglycerol kinase, putative 0.0018 0.0069 0.1873
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0053 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1848 1
Schistosoma mansoni heat shock protein 0.0034 0.017 0.0196
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0689 0.2365
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0146 0.0168
Mycobacterium ulcerans diacylglycerol kinase 0.0018 0.0069 0.0215
Brugia malayi MH1 domain containing protein 0.0008 0.0005 0.0008
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0082 0.2211
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0018 0.0069 0.2177
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0134 0.0477
Schistosoma mansoni apoferritin-2 0.0008 0.0007 0.0008
Echinococcus multilocularis microtubule associated protein 2 0.1393 0.8673 0.8673
Echinococcus granulosus Smad4 0.0008 0.0005 0.0003
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.005 0.0256
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0097 0.0485
Treponema pallidum heat shock protein 90 0.0027 0.0126 0.0645
Schistosoma mansoni alpha-glucosidase 0.0158 0.0945 0.109
Loa Loa (eye worm) ceramide kinase 0.0018 0.0069 0.0231
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0005 0.0002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0158 0.0534
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0146 0.0168
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0053 0.2818
Schistosoma mansoni hypothetical protein 0.0205 0.1235 0.1424
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0045 0.0052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0158 0.0564
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0043 0.0219
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0097 0.2631
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0146 0.0168
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0146 0.0166
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.017 0.4602
Entamoeba histolytica hypothetical protein 0.0073 0.0409 0.1399
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0007 0.0005
Brugia malayi N-terminal motif family protein 0.0218 0.1319 0.4787
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0007 0.0017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0528 0.1811
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0053 0.0158
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.017 0.0577
Onchocerca volvulus 0.0029 0.0133 0.0996
Echinococcus granulosus heat shock protein 90 0.0034 0.017 0.0193
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.019 0.0187
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0176 0.0597
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0146 0.0166
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0168 0.5626
Loa Loa (eye worm) hypothetical protein 0.0021 0.0088 0.0296
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0141 0.4684
Echinococcus granulosus pyruvate kinase 0.0017 0.0059 0.0065
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.005 0.0359
Schistosoma mansoni lamin 0.0027 0.012 0.0139
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0007 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0007 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0097 0.2631
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0022 0.0542
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.021 0.1124
Loa Loa (eye worm) hypothetical protein 0.0021 0.0088 0.0296
Loa Loa (eye worm) hypothetical protein 0.0033 0.0158 0.0537
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0053 0.1412
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0146 0.0144
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0334 0.0385
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0005 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0596 0.2044
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.017 0.4674
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0092 0.0326
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0016 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0409 0.0406
Echinococcus multilocularis heat shock protein 90 0.0034 0.017 0.0168
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0183
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0056 0.0064
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0126 0.345
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0146 0.0166
Schistosoma mansoni microtubule-associated protein tau 0.1393 0.8673 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0045 0.0154
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0146 0.0168
Trypanosoma brucei heat shock protein, putative 0.0034 0.017 0.4602
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0168 0.0191
Trypanosoma brucei heat shock protein, putative 0.0034 0.017 0.4602
Trypanosoma cruzi Sphingosine kinase 0.0018 0.0069 0.1873
Brugia malayi MH2 domain containing protein 0.0117 0.0689 0.2497
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0007 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0146 0.0522
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0087 0.0456
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0146 0.0494
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0158 0.0845
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0097 0.0309
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0146 0.0494
Schistosoma mansoni cpg binding protein 0.003 0.0144 0.0166
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0022 0.0022
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0097 0.2532
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0146 0.0494
Schistosoma mansoni hypothetical protein 0.0032 0.0158 0.0182
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0146 0.0494
Brugia malayi nuclear hormone receptor 0.0031 0.0146 0.0522
Echinococcus granulosus muscleblind protein 0.0447 0.2753 0.3173
Schistosoma mansoni heat shock protein 0.0034 0.017 0.0196
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0018 0.0069 0.0077
Echinococcus granulosus expressed protein 0.0035 0.0176 0.02
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0183
Loa Loa (eye worm) hypothetical protein 0.007 0.0393 0.1345
Echinococcus granulosus expressed protein 0.0008 0.0007 0.0006
Trypanosoma brucei Sphingosine kinase 0.0018 0.0069 0.1764
Plasmodium vivax heat shock protein 86, putative 0.0034 0.017 1
Echinococcus granulosus endoplasmin 0.0027 0.0126 0.0143
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.005 0.0256
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0056 0.0194
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0158 0.1184
Schistosoma mansoni hypothetical protein 0.0407 0.2504 0.2887
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0081 0.0255
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0452
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0097 0.0325
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0045 0.0154
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.017 0.4674
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0134 0.0437
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.021 0.1124
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0022 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.021 0.5791
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.017 0.0577
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0146 0.0144
Mycobacterium ulcerans hypothetical protein 0.0472 0.2907 1
Brugia malayi conserved hypotetical protein 0.0014 0.0045 0.0154
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0146 0.0144
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0016
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.1764
Brugia malayi hypothetical protein 0.0011 0.0022 0.007
Echinococcus granulosus dnaJ subfamily B 0.0407 0.2504 0.2885
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0158 0.0521
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0045 0.0042
Entamoeba histolytica hypothetical protein 0.0073 0.0409 0.1399
Toxoplasma gondii exonuclease III APE 0.0023 0.0097 0.3125
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0056 0.0053
Brugia malayi Importin beta-1 subunit 0.003 0.0141 0.0505
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0097 0.0343
Schistosoma mansoni lamin 0.0027 0.012 0.0139
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0134 0.0437
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0002 0.0003
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0007 0.0003
Toxoplasma gondii hypothetical protein 0.0011 0.0022 0.0508
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.1399 0.1611
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1848 1
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0045 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0364
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.021 0.0754
Schistosoma mansoni alpha glucosidase 0.0041 0.021 0.0242
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Schistosoma mansoni pyruvate kinase 0.0033 0.0158 0.0182
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0146 0.109
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0097 0.5502
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0361 1
Schistosoma mansoni dishevelled 0.0011 0.0022 0.0025
Schistosoma mansoni intermediate filament proteins 0.0027 0.012 0.0139
Brugia malayi Augmenter of liver regeneration 0.0034 0.0168 0.0603
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0146 0.0522
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.021 0.5734
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Onchocerca volvulus 0.0008 0.0007 0.0036
Toxoplasma gondii diacylglycerol kinase, putative 0.0018 0.0069 0.2177
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0168 0.0166
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.1319 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0249 0.0897
Echinococcus granulosus lysosomal alpha glucosidase 0.0184 0.1106 0.1272
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0022 0.0512
Onchocerca volvulus 0.0008 0.0007 0.0036
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0053 0.16
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0409 0.0471
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0158 0.0564
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0053 0.0051
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0146 0.0168
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0045 0.0052
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0134 0.358
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0007 0.0017
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0007 0.0001
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0045 0.0042
Brugia malayi hypothetical protein 0.0018 0.0069 0.0244
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0361 0.0413
Brugia malayi nuclear receptor NHR-88 0.0014 0.0045 0.0154
Brugia malayi Hsp90 protein 0.0014 0.0043 0.0147
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0126 0.067
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0018 0.0069 0.0364
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0158 0.9289
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.017 0.4674
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Plasmodium vivax diacylglycerol kinase, putative 0.0018 0.0069 0.3833
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0022 0.0066
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0183
Loa Loa (eye worm) hypothetical protein 0.0031 0.0146 0.0494
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0361 0.1234
Onchocerca volvulus 0.0014 0.0045 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0146 0.0522
Leishmania major pyruvate kinase 0.0033 0.0158 0.4275
Entamoeba histolytica diacylglycerol kinase, putative 0.0018 0.0069 0.0231
Echinococcus granulosus intermediate filament protein 0.0027 0.012 0.0136
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0596 0.2159
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0146 0.0522
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0045 0.0042
Leishmania major importin beta-1 subunit, putative 0.0024 0.0106 0.2796
Loa Loa (eye worm) hypothetical protein 0.0231 0.1399 0.4809
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0053 0.0174
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0007 0.0017
Echinococcus granulosus importin subunit beta 1 0.003 0.0141 0.016
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0134 0.0437
Echinococcus multilocularis expressed protein 0.0008 0.0007 0.0005
Schistosoma mansoni ferritin light chain 0.0008 0.0007 0.0008
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0045 0.0322
Trichomonas vaginalis rotamase, putative 0.0035 0.0171 0.0911
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0097 0.0109
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.012 0.0429
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0097 0.0094
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0045 0.0146
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0092 0.2501
Echinococcus multilocularis Diacylglycerol kinase theta 0.0018 0.0069 0.0067
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0022 0.0019
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0097 0.021
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0007 0.0001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0056 0.0061
Echinococcus multilocularis sphingosine kinase 1 0.0472 0.2907 0.2906
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0171 0.4623
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.088 1
Schistosoma mansoni zinc finger protein 0.0014 0.0045 0.0052
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0014 0.0043 0.0139
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0106 0.2891
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.017 0.4602
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0007 0.0008
Plasmodium vivax heat shock protein, putative 0.0014 0.0043 0.2189
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0022 0.0415
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0134 0.0437
Entamoeba histolytica diacylglycerol kinase, putative 0.0018 0.0069 0.0231
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0134 0.0477
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0361 1
Schistosoma mansoni smad 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0117 0.0396
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0045 0.0049
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0146 0.0522
Toxoplasma gondii heat shock protein 75, putative 0.0014 0.0043 0.1243
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0092 0.0309
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0045 0.0049
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0007 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1848 1
Echinococcus granulosus smad 0.0008 0.0005 0.0003
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.005 0.1318
Schistosoma mansoni hypothetical protein 0.0047 0.0249 0.0287
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0097 0.0511
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0126 0.0374
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0092 0.0103
Schistosoma mansoni hypothetical protein 0.0205 0.1235 0.1424
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0007 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0146 0.0522
Loa Loa (eye worm) hypothetical protein 0.0218 0.1319 0.4533
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0158 0.4351
Schistosoma mansoni dishevelled 0.0011 0.0022 0.0025
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0183
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.088 0.3009
Schistosoma mansoni hypothetical protein 0.0073 0.0409 0.0471
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0168 0.9905
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0005
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0018 0.0069 0.1873
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0045 0.0052
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0005 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0056 0.0194
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0022 0.0022
Echinococcus multilocularis Smad4 0.0008 0.0005 0.0002
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0158 0.0567
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0452
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0097 0.0325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0528 0.0609
Trypanosoma cruzi heat shock protein, putative 0.0014 0.0043 0.1126
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0045 0.0049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0146 0.0144
Trichomonas vaginalis bmru protein, putative 0.0018 0.0069 0.0364
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0158 0.1184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0146 0.0494
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.005 0.0256
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0478
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0088 0.028
Brugia malayi nuclear receptor RXR 0.0014 0.0045 0.0154
Echinococcus granulosus GPCR family 2 0.0032 0.0158 0.0179
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.005 0.0256
Entamoeba histolytica diacylglycerol kinase, putative 0.0018 0.0069 0.0231
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0168 0.4631
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0146 0.0494
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0134 0.358
Trichomonas vaginalis sphingosine kinase, putative 0.0018 0.0069 0.0364
Brugia malayi hypothetical protein 0.0016 0.0056 0.0194
Plasmodium falciparum diacylglycerol kinase, putative 0.0018 0.0069 0.3833
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.1848 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0007 0.0132
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0066
Echinococcus granulosus lamin dm0 0.0027 0.012 0.0136
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0043 0.1007
Loa Loa (eye worm) hypothetical protein 0.0472 0.2907 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.021 0.0208
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0092 0.5216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0022 0.007
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.021 0.0714
Echinococcus multilocularis ferritin 0.0008 0.0007 0.0005
Echinococcus granulosus pyruvate kinase 0.0033 0.0158 0.018
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0056 0.0183
Entamoeba histolytica diacylglycerol kinase, putative 0.0018 0.0069 0.0231
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0134 0.0452
Plasmodium falciparum pyruvate kinase 0.0033 0.0158 0.9289
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0134 0.0437
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0005
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0134 0.0437
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0043 0.0149
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.017 0.4602
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0088 0.4995
Schistosoma mansoni endoplasmin 0.0034 0.017 0.0196
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0111
Loa Loa (eye worm) DR-78 0.0014 0.0045 0.0146
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0361 1
Giardia lamblia Grp94/Hsp90 0.0027 0.0126 0.0374
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0134 0.0452
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.0126 0.041
Echinococcus multilocularis pyruvate kinase 0.0017 0.0059 0.0057
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0087 0.0456
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Brugia malayi diacylglycerol kinase 0.0018 0.0069 0.0244
Trichomonas vaginalis diacylglycerol kinase, putative 0.0018 0.0069 0.0364
Brugia malayi isocitrate dehydrogenase 0.0016 0.0053 0.0184
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0053 0.2818
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0053 0.16
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.021 0.1124
Brugia malayi Endoplasmin precursor 0.0034 0.017 0.0609
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Echinococcus multilocularis snurportin 1 0.0319 0.1949 0.1947
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0146 0.0166
Echinococcus granulosus cpg binding protein 0.003 0.0144 0.0163
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0158 0.0537
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0018 0.0069 0.0067
Loa Loa (eye worm) hypothetical protein 0.0023 0.0097 0.0324
Loa Loa (eye worm) hypothetical protein 0.0031 0.0146 0.0494
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0043 0.0141
Brugia malayi hypothetical protein 0.0014 0.0045 0.0154
Brugia malayi photoreceptor-specific nuclear receptor 0.0266 0.1617 0.5871
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0231
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.005 0.0256
Echinococcus granulosus Diacylglycerol kinase theta 0.0018 0.0069 0.0077
Echinococcus multilocularis muscleblind protein 1 0.0447 0.2753 0.2752
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0134 0.0477
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0097 0.5502
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.021 0.1124
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0014 0.0043 0.0307
Echinococcus granulosus lamin 0.0027 0.012 0.0136
Brugia malayi nuclear receptor NHR-88 0.0031 0.0146 0.0522
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0007 0.0016
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0043 0.0139
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0097 0.7528
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Echinococcus granulosus microtubule associated protein 2 0.1393 0.8673 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0146 0.0494
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0158 0.0537
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Trypanosoma cruzi diacylglycerol kinase, putative 0.0018 0.0069 0.1873
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.005 0.1202
Echinococcus granulosus pyruvate kinase 0.0033 0.0158 0.018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0146 0.0166
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0106 0.0561
Schistosoma mansoni coup transcription factor 0.0031 0.0146 0.0168
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0018 0.0069 0.008
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0007 0.0132
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Loa Loa (eye worm) heat shock protein 90 0.0034 0.017 0.0577
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0007 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0146 0.0522
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0146
Trypanosoma brucei heat shock protein, putative 0.0034 0.017 0.4602
Echinococcus multilocularis GPCR, family 2 0.0032 0.0158 0.0155
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0158 0.5276
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0059 0.3194
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0092 0.24
Brugia malayi nuclear hormone receptor 0.0014 0.0045 0.0154
Onchocerca volvulus 0.0008 0.0007 0.0036
Leishmania major diacylglycerol kinase, putative 0.0018 0.0069 0.1764
Echinococcus multilocularis importin subunit beta 1 0.003 0.0141 0.0139
Trypanosoma brucei heat shock protein, putative 0.0034 0.017 0.4602
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.0126 1
Echinococcus multilocularis heat shock protein 0.0034 0.017 0.0168
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0043 0.0047
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0045 0.0146
Echinococcus multilocularis pyruvate kinase 0.0026 0.0115 0.0113
Onchocerca volvulus 0.0031 0.0146 0.109
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0097 0.2532
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0018 0.0069 0.0364
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.021 0.1124
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0092 0.5216
Schistosoma mansoni sphingosine kinase A B 0.0472 0.2907 0.3352
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0022 0.0019
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0171 0.5706
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0018 0.0069 0.2177
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0106 0.0561
Echinococcus granulosus snurportin 1 0.0319 0.1949 0.2245
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.021 0.0714
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0146 0.0144
Trichomonas vaginalis diacylglycerol kinase, putative 0.0018 0.0069 0.0364
Toxoplasma gondii Hsp90 domain-containing protein 0.0014 0.0043 0.1243
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0134 0.1451
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0088 0.4995
Brugia malayi MH2 domain containing protein 0.0008 0.0005 0.0008
Schistosoma mansoni nuclear receptor 0.0014 0.0045 0.0052
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0045 0.0154
Leishmania major diacylglycerol kinase-like protein 0.0018 0.0069 0.1764
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.088 0.3009
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0146 0.0166
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0171 0.0579
Trypanosoma brucei heat shock protein, putative 0.0034 0.017 0.4602
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0059 0.1814
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0097 0.0324
Entamoeba histolytica hypothetical protein, conserved 0.0472 0.2907 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0146 0.0144
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0158 0.0537
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0043 0.2189
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0069 0.1873
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0007 0.0026
Echinococcus multilocularis smad 0.0008 0.0005 0.0002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0056 0.0064
Entamoeba histolytica Ran family GTPase 0.0022 0.0092 0.0309
Echinococcus multilocularis lamin dm0 0.0027 0.012 0.0118
Brugia malayi ecdysteroid receptor 0.0031 0.0146 0.0522
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0158 0.1184
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0045 0.0049
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0007 0.0132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0045 0.0049
Brugia malayi CXXC zinc finger family protein 0.0029 0.0133 0.0477
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0168 0.4631
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0088 0.0296
Mycobacterium tuberculosis Conserved protein 0.0472 0.2907 1
Toxoplasma gondii heat shock protein HSP90 0.0034 0.017 0.568
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0146 0.0144
Echinococcus granulosus pyruvate kinase 0.0017 0.0059 0.0065
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0126 0.3362
Schistosoma mansoni cpg binding protein 0.0029 0.0133 0.0154
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0141 0.3795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0146 0.0494
Schistosoma mansoni ferritin light chain 0.0008 0.0007 0.0008
Leishmania major heat shock protein, putative 0.0014 0.0043 0.1007
Echinococcus multilocularis heat shock protein 90 0.0027 0.0126 0.0124
Trichomonas vaginalis sphingosine kinase, putative 0.0018 0.0069 0.0364
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0002 0.0003
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0171 0.4623
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0092 0.0184
Schistosoma mansoni dep domain containing protein 0.0011 0.0022 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0081 0.0255
Schistosoma mansoni nuclear receptor 0.0014 0.0045 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0007 0.0017
Echinococcus multilocularis geminin 0.0205 0.1235 0.1233
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0008 0.0002 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0146 0.0168
Brugia malayi intermediate filament protein 0.0027 0.012 0.0429
Echinococcus multilocularis cpg binding protein 0.003 0.0144 0.0141
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0045 0.0052
Schistosoma mansoni ap endonuclease 0.0023 0.0097 0.0111
Onchocerca volvulus 0.0011 0.0022 0.0146
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0018 0.0069 0.008
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0361 0.1303
Brugia malayi Muscleblind-like protein 0.0447 0.2753 1
Onchocerca volvulus 0.0106 0.062 0.4692
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.005 0.0256
Trichomonas vaginalis rotamase, putative 0.0035 0.0176 0.094
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0022 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0081 0.0255
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0005 0.0002
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0176 0.0631
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0066
Brugia malayi Glycosyl hydrolases family 31 protein 0.0184 0.1106 0.401
Echinococcus multilocularis pyruvate kinase 0.0017 0.0059 0.0057
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.1848 0.6355
Schistosoma mansoni heat shock protein 0.0014 0.0043 0.0049
Echinococcus granulosus geminin 0.0205 0.1235 0.1422
Schistosoma mansoni importin beta-1 0.003 0.0141 0.0163
Brugia malayi hypothetical protein 0.0016 0.0056 0.0194
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0158 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0146 0.0522
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0126 0.345
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0069 0.1764
Echinococcus granulosus ceramide kinase 0.0018 0.0069 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0528 0.0609
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0045 0.0049
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0133 0.0451
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0361 0.1234
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0018 0.0069 0.1764
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0007 0.0132
Schistosoma mansoni Smad4 0.0008 0.0005 0.0005
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0146 0.0168
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0088 0.028
Leishmania major GTP-binding protein, putative 0.0022 0.0092 0.24
Plasmodium falciparum endoplasmin, putative 0.0021 0.0087 0.4884
Schistosoma mansoni ferritin 0.0008 0.0007 0.0008
Loa Loa (eye worm) diacylglycerol kinase 2 0.0018 0.0069 0.0231
Loa Loa (eye worm) hypothetical protein 0.0447 0.2753 0.947
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0158 0.0567
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0452
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0134 0.0452
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0022 0.0022
Schistosoma mansoni apoferritin-2 0.0008 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0146 0.0494
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.012 0.0407
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0018 0.0069 0.1873
Schistosoma mansoni ran 0.0022 0.0092 0.0106
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0022 0.0415
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0053 0.0051
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0146 0.0166
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0146 0.109
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.1848 1
Schistosoma mansoni ap endonuclease 0.0023 0.0097 0.0111
Plasmodium vivax heat shock protein 90, putative 0.0014 0.0043 0.2189
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.1764
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0043 0.2189
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0022 0.0542
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0409 0.0469
Schistosoma mansoni survival motor neuron protein 0.0047 0.0249 0.0287
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0141 0.3795
Loa Loa (eye worm) hypothetical protein 0.0447 0.2753 0.947
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0146 0.0522
Schistosoma mansoni hypothetical protein 0.0032 0.0158 0.0182
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0168 0.4631
Loa Loa (eye worm) hypothetical protein 0.0021 0.0088 0.0296
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0158 0.0179
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0066
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0097 0.0511
Loa Loa (eye worm) hypothetical protein 0.0266 0.1617 0.556
Loa Loa (eye worm) Smad1 0.0008 0.0005 0.0007
Loa Loa (eye worm) intermediate filament protein 0.0027 0.012 0.0407
Brugia malayi MH1 domain containing protein 0.0008 0.0005 0.0008
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0361 0.0416
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0134 0.1451
Onchocerca volvulus 0.0027 0.012 0.0897
Onchocerca volvulus 0.0018 0.0069 0.051
Echinococcus granulosus ferritin 0.0008 0.0007 0.0006
Schistosoma mansoni rotamase 0.0035 0.0176 0.0203
Brugia malayi hypothetical protein 0.0231 0.1399 0.5078
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0158 0.0845
Plasmodium vivax endoplasmin, putative 0.0034 0.017 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0059 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0183
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0158 0.1733
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.021 0.1124
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0158 0.4351
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0106 0.0561
Echinococcus multilocularis pyruvate kinase 0.0017 0.0059 0.0057
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0689 0.2365
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0002 0.0003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0146 0.0168
Echinococcus multilocularis pyruvate kinase 0.0033 0.0158 0.0156
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.01
Schistosoma mansoni hypothetical protein 0.0018 0.0069 0.008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0158 0.0179
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0168 0.5626
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0022 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.021 0.1124
Giardia lamblia Pyruvate kinase 0.0033 0.0158 0.0554
Echinococcus multilocularis endoplasmin 0.0027 0.0126 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0146 0.0522
Echinococcus multilocularis ceramide kinase 0.0018 0.0069 0.0067
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0231
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0528 0.0607
Brugia malayi tailless protein 0.0014 0.0045 0.0154
Leishmania major hypothetical protein, conserved 0.0034 0.0168 0.4559
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0146 0.0144
Trichomonas vaginalis ferritin, putative 0.0008 0.0007 0.0027
Echinococcus granulosus heat shock protein 90 0.0027 0.0126 0.0143
Loa Loa (eye worm) hypothetical protein 0.0031 0.0146 0.0494
Echinococcus granulosus sphingosine kinase 1 0.0472 0.2907 0.335
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0126 0.0143
Brugia malayi nuclear receptor RXR 0.0016 0.0056 0.0194
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0053 0.1412
Brugia malayi RNA, U transporter 1 0.0085 0.0486 0.1757
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0184 0.1106 0.3798
Brugia malayi hypothetical protein 0.0073 0.0409 0.1477
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0528 0.0609
Onchocerca volvulus 0.0047 0.0249 0.1874
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0534
Leishmania major sphingosine kinase A, B, putative 0.0018 0.0069 0.1764
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.005 0.0163
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.021 0.1124
Loa Loa (eye worm) oxidoreductase 0.0008 0.0007 0.0016
Chlamydia trachomatis pyruvate kinase 0.0033 0.0158 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0081 0.0255
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0146 0.0168
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0134 0.0437
Loa Loa (eye worm) hypothetical protein 0.0031 0.0146 0.0494
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0045 0.0154
Plasmodium vivax importin-beta 2, putative 0.003 0.0141 0.8247
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0027 0.0126 0.1363
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0528 0.0526
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0022 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0146 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0146 0.0522
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0018 0.0069 0.0067
Trypanosoma brucei heat shock protein, putative 0.0034 0.017 0.4602
Onchocerca volvulus 0.0008 0.0007 0.0036
Brugia malayi DIX domain containing protein 0.0011 0.0022 0.007
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.021 0.7077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0146 0.0494
Trichomonas vaginalis heat shock protein, putative 0.0034 0.017 0.0907
Brugia malayi hypothetical protein 0.0014 0.0045 0.0154
Entamoeba histolytica hypothetical protein 0.0024 0.0106 0.0357
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0171 0.4694
Plasmodium vivax diacylglycerol kinase, putative 0.0018 0.0069 0.3833
Mycobacterium tuberculosis Diacylglycerol kinase 0.0018 0.0069 0.0215
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0018 0.0069 0.0364
Echinococcus multilocularis muscleblind protein 0.0447 0.2753 0.2752
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0045 0.0052
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.017 0.0619
Schistosoma mansoni pyruvate kinase 0.0033 0.0158 0.0182
Onchocerca volvulus 0.0029 0.0134 0.0997
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0022 0.0025
Schistosoma mansoni ferritin 0.0008 0.0007 0.0008
Leishmania major heat shock protein 83-1 0.0034 0.017 0.4602
Trypanosoma brucei heat shock protein, putative 0.0034 0.017 0.4602
Schistosoma mansoni hypothetical protein 0.0319 0.1949 0.2247
Onchocerca volvulus 0.0027 0.012 0.0897
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0022 0.007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0528 0.0526
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0045 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.1848 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0294 1
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.1399 0.1397

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1259 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.7456 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 10.3225 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.