Detailed information for compound 1303722

Basic information

Technical information
  • TDR Targets ID: 1303722
  • Name: 1-ethyl-N-[3-(2-ethylpiperidin-1-yl)propyl]-2 ,3-dimethylindole-5-carboxamide
  • MW: 369.544 | Formula: C23H35N3O
  • H donors: 1 H acceptors: 1 LogP: 4.54 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1CCCCN1CCCNC(=O)c1ccc2c(c1)c(C)c(n2CC)C
  • InChi: 1S/C23H35N3O/c1-5-20-10-7-8-14-25(20)15-9-13-24-23(27)19-11-12-22-21(16-19)17(3)18(4)26(22)6-2/h11-12,16,20H,5-10,13-15H2,1-4H3,(H,24,27)
  • InChiKey: TXFUVYDUOHOUDL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-ethyl-N-[3-(2-ethyl-1-piperidyl)propyl]-2,3-dimethyl-indole-5-carboxamide
  • 1-ethyl-N-[3-(2-ethyl-1-piperidinyl)propyl]-2,3-dimethyl-5-indolecarboxamide
  • 1-ethyl-N-[3-(2-ethylpiperidin-1-yl)propyl]-2,3-dimethyl-indole-5-carboxamide
  • NCGC00128830-01
  • G119-0779

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.008 0.0714
Leishmania major trypanothione reductase 0.0048 0.0424 0.3795
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0545 0.188
Trypanosoma cruzi mitochondrial protein 99, putative 0.0023 0.0172 0.1539
Echinococcus granulosus neutral sphingomyelinase 0.0023 0.0172 0.0372
Trypanosoma brucei trypanothione reductase 0.0048 0.0424 0.3795
Schistosoma mansoni alpha glucosidase 0.0038 0.0328 0.0787
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0023 0.0172 0.0569
Plasmodium vivax exodeoxyribonuclease III, putative 0.0023 0.0172 0.0594
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0115 0.1119 1
Leishmania major GTP-binding protein, putative 0.0021 0.0146 0.1305
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0138 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0915 0.3887
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.008 0.0714
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.0888
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0113
Giardia lamblia Kinase, PLK 0.0096 0.0915 0.8181
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0103 0.0922
Plasmodium falciparum glutathione reductase 0.0017 0.0103 0.0356
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1054 0.3401
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0113
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0488 0.1134
Schistosoma mansoni neutral sphingomyelinase 0.0023 0.0172 0.0413
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0023 0.0172 0.0731
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0149 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0501 0.0484
Mycobacterium ulcerans beta-lactamase 0.0039 0.0338 0.1166
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0039 0.0337 0.1161
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0103 0.0206
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0172 0.0715
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0592 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0552 0.1824
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0023 0.0172 0.0594
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0488 0.1172
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0226 0.0502
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0146 0.0482
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0023 0.0172 0.0731
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0103 0.0922
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0023 0.0172 0.1539
Loa Loa (eye worm) hypothetical protein 0.0021 0.0149 0.0494
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0039 0.0337 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0442 0.1061
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0661 0.5597
Brugia malayi Muscleblind-like protein 0.015 0.1478 0.614
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0424 0.0981
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0023 0.0172 0.0569
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0115 0.1119 0.3857
Leishmania major hypothetical protein, conserved 0.0023 0.0172 0.1539
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0149 0.1336
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0034 0.0017
Schistosoma mansoni ap endonuclease 0.0115 0.1119 0.2686
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0103 0.0248
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.0888
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0351 0.0804
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.1539
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0645 0.1512
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0103 0.0356
Mycobacterium ulcerans lipase LipD 0.0039 0.0338 0.1166
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0915 0.3801
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0338 0.1436
Treponema pallidum hypothetical protein 0.0023 0.0172 0.0247
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0337 0.301
Brugia malayi hypothetical protein 0.0073 0.0687 0.2852
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0338 0.084
Leishmania major DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Brugia malayi ecdysteroid receptor 0.001 0.0034 0.0142
Onchocerca volvulus 0.0054 0.0488 0.1956
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.1713 0.1699
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0328 0.2931
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0172 0.1539
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0424 0.1149
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0915 0.3887
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0103 0.0922
Schistosoma mansoni ap endonuclease 0.0115 0.1119 0.2686
Echinococcus multilocularis muscleblind protein 0.015 0.1478 0.1463
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0131 0.0114
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0034 0.0017
Mycobacterium tuberculosis Probable reductase 0.0109 0.1054 0.3401
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0113
Loa Loa (eye worm) hypothetical protein 0.0046 0.0407 0.1345
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0338 0.1404
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0501 0.1202
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0129 0.0425
Schistosoma mansoni nuclear hormone receptor 0.001 0.0034 0.0082
Echinococcus granulosus GPCR family 2 0.0019 0.0129 0.0267
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1054 0.3401
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0915 0.0899
Schistosoma mansoni immunophilin 0.0039 0.0337 0.0809
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0442 0.0425
Schistosoma mansoni synaptojanin 0.0023 0.0172 0.0413
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.2408 0.7959
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0419 0.178
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0328 0.1393
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0034 0.0142
Loa Loa (eye worm) MBCTL1 0.0061 0.0565 0.1867
Schistosoma mansoni bromodomain containing protein 0.0073 0.0686 0.1648
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0023 0.0172 0.0594
Trypanosoma brucei RNA editing exonuclease 2 0.0023 0.0172 0.1539
Leishmania major endonuclease/exonuclease protein-like protein 0.0023 0.0172 0.1539
Trypanosoma cruzi ISWI complex protein 0.0017 0.0111 0.0991
Schistosoma mansoni cpg binding protein 0.0033 0.0269 0.0646
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0115 0.1119 0.3857
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0915 0.8181
Loa Loa (eye worm) hypothetical protein 0.0028 0.0222 0.0735
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0103 0.0086
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0103 0.0356
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0351 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0034 0.0142
Trypanosoma brucei unspecified product 0.0015 0.0082 0.0735
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0146 0.1305
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0146 0.1305
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0034 0.0142
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0488 0.1134
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0552 0.2291
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0115 0.1119 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0236 0.236 0.2346
Trichomonas vaginalis ran, putative 0.0021 0.0146 0.062
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.008 0.0197
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0039 0.0337 0.0769
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0039 0.0337 0.0835
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0149 0.0634
Onchocerca volvulus Putative neutral sphingomyelinase 0.0023 0.0172 0.0594
Mycobacterium tuberculosis Conserved protein 0.0039 0.0338 0.084
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0149 0.0669
Treponema pallidum hypothetical protein 0.0289 0.29 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0146 0.0636
Trichomonas vaginalis ap endonuclease, putative 0.0115 0.1119 0.4751
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0103 0.0922
Trichomonas vaginalis esterase, putative 0.0039 0.0338 0.1436
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0574 0.1379
Loa Loa (eye worm) hypothetical protein 0.008 0.0756 0.2499
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0328 0.1393
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.1254
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0023 0.0172 0.0155
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0592 0.1955
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0115 0.1119 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0149 0.0359
Brugia malayi follicle stimulating hormone receptor 0.0241 0.2408 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0545 0.188
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Schistosoma mansoni hypothetical protein 0.0073 0.0687 0.1649
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0419 0.178
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0915 0.8181
Mycobacterium ulcerans hypothetical protein 0.0039 0.0338 0.1166
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0488 0.0471
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0115 0.1119 0.2655
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.118 0.3848
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.1539
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0915 0.2164
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0172 0.0715
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0289 0.29 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.1539
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0149 0.0515
Loa Loa (eye worm) hypothetical protein 0.0039 0.0338 0.1118
Echinococcus multilocularis geminin 0.0171 0.1686 0.1671
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0354 0.0812
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0915 0.3887
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0915 0.3887
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0289 0.29 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0034 0.0082
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0115 0.1119 0.1103
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0146 0.0503
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1054 0.3401
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.008 0.0714
Brugia malayi RNA binding protein 0.0064 0.0592 0.2457
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0146 0.0309
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0023 0.0172 0.1539
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0034 0.0142
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0023 0.0172 0.0569
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0034 0.004
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0338 0.084
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0328 0.1393
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0034 0.0017
Echinococcus granulosus cpg binding protein 0.0033 0.0269 0.0606
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0115 0.1119 0.3857
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0338 0.0812
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0034 0.0082
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0149 0.0494
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0328 0.1084
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0034 0.0281 0.0264
Schistosoma mansoni thyroid hormone receptor 0.001 0.0034 0.0082
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0915 0.3025
Loa Loa (eye worm) hypothetical protein 0.005 0.0442 0.1461
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0172 0.1539
Treponema pallidum exodeoxyribonuclease (exoA) 0.0115 0.1119 0.363
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0328 0.2931
Echinococcus granulosus synaptojanin 1 0.0023 0.0172 0.0372
Toxoplasma gondii ABC1 family protein 0.0039 0.0338 0.3022
Loa Loa (eye worm) hypothetical protein 0.015 0.1478 0.4887
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0103 0.0922
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0149 0.1336
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0501 0.2079
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0545 0.158
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.1539
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0915 0.8181
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0337 0.301
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0023 0.0172 0.1539
Brugia malayi steroid hormone receptor 0.001 0.0034 0.0142
Loa Loa (eye worm) glutathione reductase 0.0048 0.0424 0.1403
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0023 0.0172 0.1539
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0034 0.0017
Onchocerca volvulus 0.0236 0.2354 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0356 0.1176
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0592 0.0575
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0252 0.2522 0.8649
Leishmania major importin beta-1 subunit, putative 0.0023 0.0168 0.1499
Trypanosoma brucei glucosidase, putative 0.0038 0.0328 0.2931
Loa Loa (eye worm) hypothetical protein 0.0238 0.2379 0.7865
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0442 0.1023
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0661 0.5912
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0113
Echinococcus multilocularis muscleblind protein 1 0.015 0.1478 0.1463
Loa Loa (eye worm) hypothetical protein 0.0039 0.0338 0.1118
Echinococcus granulosus snurportin 1 0.0301 0.3025 0.7252
Trypanosoma cruzi ISWI complex protein 0.0017 0.0111 0.0991
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0129 0.0534
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0328 0.1393
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0034 0.004
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0023 0.0172 0.1539
Loa Loa (eye worm) hypothetical protein 0.0061 0.0565 0.1867
Mycobacterium tuberculosis Conserved protein 0.0039 0.0338 0.084
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.008 0.0339
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0149 0.1336
Leishmania major pantothenate kinase subunit, putative 0.0023 0.0172 0.1539
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0023 0.0172 0.0569
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0146 0.1305
Mycobacterium tuberculosis Conserved protein 0.0039 0.0338 0.084
Brugia malayi Importin beta-1 subunit 0.0028 0.0222 0.0924
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0023 0.0172 0.0731
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0424 0.1464
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0115 0.1119 0.3698
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0661 0.0645
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0338 0.1436
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0034 0.0017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.008 0.0339
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0036 0.0018
Leishmania major hypothetical protein, conserved 0.0023 0.0172 0.1539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0034 0.0113
Trichomonas vaginalis Phospholipase C precursor, putative 0.0023 0.0172 0.0731
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0115 0.1119 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0338 0.1118
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.1054 0.2796
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0034 0.004
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.1713 0.4089
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.1539
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0915 0.2197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0034 0.0113
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0039 0.0337 0.143
Schistosoma mansoni hypothetical protein 0.0023 0.0173 0.0415
Giardia lamblia hypothetical protein 0.0023 0.0172 0.1539
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.1713 0.1699
Brugia malayi Pre-SET motif family protein 0.0207 0.2061 0.856
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0592 0.1955
Plasmodium falciparum DNase I-like protein, putative 0.0023 0.0172 0.0594
Plasmodium falciparum thioredoxin reductase 0.0048 0.0424 0.1464
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0023 0.0172 0.0888
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0534 0.4778
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0592 0.2457
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0424 0.0407
Plasmodium falciparum glutathione reductase 0.0048 0.0424 0.1464
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0039 0.0337 0.1399
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0023 0.0172 0.0372
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0328 0.2931
Schistosoma mansoni hypothetical protein 0.0019 0.0129 0.0309
Schistosoma mansoni alpha-glucosidase 0.0149 0.1465 0.3519
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0113
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0565 0.1319
Schistosoma mansoni cpg binding protein 0.0033 0.0269 0.0646
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0168 0.0712
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0328 0.1393
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0687 0.1613
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0168 0.1499
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0034 0.0142
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0172 0.0715
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1054 0.3401
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0424 0.1403
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0149 0.1336
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0057 0.0236
Brugia malayi Thioredoxin reductase 0.0048 0.0424 0.1763
Schistosoma mansoni ran 0.0021 0.0146 0.035
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0023 0.0172 0.0731
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0338 0.084
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0328 0.2387
Echinococcus granulosus dna polymerase kappa 0.0021 0.0149 0.0318
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.5841
Loa Loa (eye worm) hypothetical protein 0.0023 0.0172 0.0569
Plasmodium vivax SET domain protein, putative 0.003 0.0244 0.084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0034 0.0113
Schistosoma mansoni DNA polymerase eta 0.0021 0.0149 0.0359
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0023 0.0172 0.0888
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0034 0.0082
Schistosoma mansoni hypothetical protein 0.0352 0.3547 0.8518
Leishmania major RNA-editing complex protein MP100, putative 0.0023 0.0172 0.1539
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0545 0.1309
Schistosoma mansoni coup transcription factor 0.001 0.0034 0.0082
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0039 0.0337 0.301
Schistosoma mansoni zinc finger protein 0.0024 0.0178 0.0426
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0023 0.0172 0.1539
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.0888
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0328 0.0311
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0023 0.0172 0.0569
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0115 0.1119 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0103 0.0922
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0236 0.236 0.5648
Giardia lamblia Inositol 5-phosphatase 4 0.0023 0.0172 0.1539
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0168 0.0712
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0172 0.0715
Brugia malayi glutathione reductase 0.0048 0.0424 0.1763
Schistosoma mansoni hypothetical protein 0.0019 0.0129 0.0309
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0915 0.8041
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0545 0.0528
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0023 0.0172 0.0731
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0103 0.5
Echinococcus granulosus FTZ F1 alpha 0.001 0.0034 0.004
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0149 0.0359
Schistosoma mansoni survival motor neuron protein 0.0049 0.0432 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0034 0.0142
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0661 0.2186
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0338 0.1118
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0915 0.3887
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0661 0.1588
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0222 0.1988
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0289 0.29 1
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0488 0.1172
Echinococcus multilocularis GPCR, family 2 0.0019 0.0129 0.0111
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0023 0.0172 0.0731
Schistosoma mansoni cript-related 0.0023 0.0172 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.1539
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0034 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0034 0.0142
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.2379 0.2366
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0103 0.0922
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0552 0.1824
Echinococcus granulosus tar DNA binding protein 0.0064 0.0592 0.1384
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0034 0.0113
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0034 0.0142
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0103 0.0922
Brugia malayi CXXC zinc finger family protein 0.0029 0.023 0.0955
Leishmania major DNA polymerase eta, putative 0.0021 0.0149 0.1336
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.1713 0.5664
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0338 0.1436
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.023 0.076
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.4164 0.4154
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0103 0.0922
Loa Loa (eye worm) hypothetical protein 0.0039 0.0338 0.1118
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0149 0.0132
Schistosoma mansoni hypothetical protein 0.0412 0.4164 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0082 0.0735
Trichomonas vaginalis fk506-binding protein, putative 0.0039 0.0337 0.143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0034 0.0113
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0488 0.1956
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0034 0.0017
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0023 0.0172 0.0413
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0034 0.0082
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0039 0.0337 0.0809
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0131 0.0315
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0545 0.4875
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0338 0.3022
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0149 0.1336
Loa Loa (eye worm) hypothetical protein 0.0023 0.0172 0.0569
Loa Loa (eye worm) histone methyltransferase 0.001 0.0036 0.0119
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0039 0.0337 0.0769
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0565 0.2346
Onchocerca volvulus 0.0029 0.023 0.0843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0501 0.1164
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0915 0.3887
Loa Loa (eye worm) FKBP5 protein 0.0039 0.0337 0.1113
Schistosoma mansoni hypothetical protein 0.0017 0.0111 0.0266
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0338 0.084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0034 0.004
Leishmania major hypothetical protein, conserved 0.0039 0.0338 0.3022
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0034 0.0142
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0592 0.142
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0592 0.142
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0023 0.0172 0.1539
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0356 0.1478
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0113
Onchocerca volvulus 0.0023 0.0172 0.0594
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0034 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0338 0.1118
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0103 0.0922
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.5841
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0172 0.1539
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0149 0.0634
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0289 0.29 1
Echinococcus granulosus geminin 0.0171 0.1686 0.4023
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0023 0.0172 0.0372
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0103 0.0922
Brugia malayi TAR-binding protein 0.0064 0.0592 0.2457
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0023 0.0172 0.0888
Schistosoma mansoni synaptojanin 0.0023 0.0172 0.0413
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0328 0.1393
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Trichomonas vaginalis ap endonuclease, putative 0.0115 0.1119 0.4751
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0222 0.1988
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0039 0.0337 0.301
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0129 0.0267
Brugia malayi beta-lactamase family protein 0.0039 0.0338 0.1404
Echinococcus multilocularis zinc finger protein 0.0024 0.0178 0.016
Schistosoma mansoni hypothetical protein 0.0041 0.0356 0.0854
Schistosoma mansoni hypothetical protein 0.0019 0.0129 0.0309
Loa Loa (eye worm) hypothetical protein 0.015 0.1478 0.4887
Schistosoma mansoni kinase 0.0049 0.0432 0.1037
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0039 0.0337 0.2472
Schistosoma mansoni alpha-glucosidase 0.0149 0.1465 0.3519
Brugia malayi RNA, U transporter 1 0.008 0.0756 0.3142
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1054 0.3401
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0058 0.0241
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0034 0.0082
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0687 0.067
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0115 0.1119 1
Echinococcus multilocularis deoxyribonuclease 1 2 0.0023 0.0172 0.0155
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0172 0.1539
Brugia malayi exodeoxyribonuclease III family protein 0.0115 0.1119 0.4646
Brugia malayi nuclear receptor NHR-88 0.001 0.0034 0.0142
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0338 0.084
Onchocerca volvulus 0.0023 0.0172 0.0594
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.008 0.0339
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0115 0.1119 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0338 0.084
Schistosoma mansoni immunophilin 0.0039 0.0337 0.0809
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.0888
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0149 0.0621
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0023 0.0172 0.0888
Onchocerca volvulus 0.01 0.0963 0.4002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0034 0.004
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0034 0.0281 0.0635
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.008 0.0339
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0337 0.301
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0023 0.0172 0.0569
Schistosoma mansoni hypothetical protein 0.0301 0.3025 0.7264
Leishmania major glycosyl hydrolase-like protein 0.0014 0.008 0.0714
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0103 0.0356
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0244 0.2177
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0172 0.1539
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0058 0.0241
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0131 0.0315
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0172 0.0715
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0545 0.1309
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0034 0.0017
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.1713 0.7117
Leishmania major fk506-binding protein 1-like protein 0.0039 0.0337 0.301
Echinococcus multilocularis snurportin 1 0.0301 0.3025 0.3013
Loa Loa (eye worm) RNA binding protein 0.0064 0.0592 0.1955
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0034 0.0082
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0565 0.0548
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0023 0.0172 0.0155
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0115 0.1119 0.363
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0661 0.5912
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0338 0.3022
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0034 0.0017
Brugia malayi PHD-finger family protein 0.003 0.024 0.0995
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.008 0.0339
Brugia malayi mbt repeat family protein 0.0054 0.0488 0.2027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0244 0.0585
Schistosoma mansoni hypothetical protein 0.0049 0.0432 0.1037
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0488 0.1172
Onchocerca volvulus 0.0039 0.0338 0.131
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0338 0.0772
Plasmodium vivax importin-beta 2, putative 0.0028 0.0222 0.0767
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.008 0.0339
Onchocerca volvulus 0.003 0.0244 0.0902
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0328 0.1393
Trypanosoma brucei unspecified product 0.0015 0.0082 0.0735
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0501 0.1164
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.3025 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0172 0.0715
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Schistosoma mansoni thyroid hormone receptor 0.001 0.0034 0.0082
Schistosoma mansoni zinc finger protein 0.0017 0.0111 0.0266
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0146 0.1305
Schistosoma mansoni hypothetical protein 0.0019 0.0129 0.0309
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0545 0.4875
Trichomonas vaginalis immunophilin, putative 0.0039 0.0337 0.143
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0338 0.1166
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0661 0.2747
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0034 0.004
Giardia lamblia DINP protein human, muc B family 0.0021 0.0149 0.1336
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.1539
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0222 0.0205
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0039 0.0337 0.1161
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0103 0.0922
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0039 0.0337 0.1161
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0146 0.1305
Schistosoma mansoni hypothetical protein 0.0171 0.1686 0.4048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0172 0.1539
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0338 0.1166
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.2379 0.5695
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0129 0.0267
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0501 0.1202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0338 0.0812
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0488 0.1613
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0023 0.0172 0.1539
Brugia malayi Bromodomain containing protein 0.0043 0.0379 0.1572
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0039 0.0337 0.1399
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0149 0.0515
Loa Loa (eye worm) hypothetical protein 0.0023 0.0172 0.0569
Loa Loa (eye worm) hypothetical protein 0.0039 0.0338 0.1118
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.5841
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0488 0.0471
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0023 0.0172 0.0731
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.5841
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0039 0.0337 0.2472
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0034 0.0142
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0645 0.0628
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0545 0.188
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0149 0.1336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0442 0.1061
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0146 0.0503
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.118 0.3284
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0338 0.1166
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0915 0.3797
Brugia malayi Pre-SET motif family protein 0.003 0.0244 0.1012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0501 0.0484
Echinococcus granulosus zinc finger protein 0.0024 0.0178 0.0385
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0103 0.0428
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0103 0.0922
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0023 0.0172 0.0594
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0039 0.0337 0.301
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0661 0.5912
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0034 0.0082
Trypanosoma brucei unspecified product 0.0021 0.0149 0.1336
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0018 0.0043
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.008 0.0339
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0131 0.0274
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0432 0.1793
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0039 0.0337 0.1113
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0565 0.0548
Onchocerca volvulus 0.0039 0.0338 0.131
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.0264
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0034 0.0082
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0034 0.0113
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0212 0.0195
Mycobacterium tuberculosis Probable exported protein 0.0023 0.0172 0.0247
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0034 0.0142
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0687 0.1649
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.0888
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0328 0.2931
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0103 0.0438
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.118 0.3848
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2061 0.6813
Trypanosoma brucei polo-like protein kinase 0.0096 0.0915 0.8181
Schistosoma mansoni carbon catabolite repressor protein 0.0023 0.0172 0.0413
Echinococcus granulosus dnaJ subfamily B 0.0412 0.4164 1
Leishmania major hypothetical protein, conserved 0.0023 0.0172 0.1539
Onchocerca volvulus 0.0049 0.0432 0.1713
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0034 0.004
Plasmodium falciparum thioredoxin reductase 0.0017 0.0103 0.0356
Plasmodium vivax glutathione reductase, putative 0.0048 0.0424 0.1464
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0501 0.1655
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0103 0.0438
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0129 0.0534
Brugia malayi hypothetical protein 0.0238 0.2379 0.9882
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0129 0.0111
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0328 0.2387
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0082 0.0735
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0034 0.0142
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0212 0.0509
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0129 0.0111
Brugia malayi nuclear hormone receptor 0.001 0.0034 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0034 0.0142
Loa Loa (eye worm) hypothetical protein 0.0054 0.0488 0.1613
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0338 0.1436
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0023 0.0172 0.0594
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0103 0.0356
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0337 0.301
Echinococcus multilocularis cpg binding protein 0.0033 0.0269 0.0252
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0103 0.0922
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0023 0.0172 0.0888
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0212 0.0469
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0103 0.0922
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0338 0.3022
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0039 0.0337 0.301
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0244 0.0226
Leishmania major hypothetical protein, conserved 0.0017 0.0111 0.0991
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0034 0.004
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0149 0.0621
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0149 0.0318
Loa Loa (eye worm) hypothetical protein 0.0023 0.0172 0.0569
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0103 0.0922
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0103 0.0922
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0328 0.0748
Echinococcus granulosus importin subunit beta 1 0.0028 0.0222 0.0494
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0023 0.0172 0.1539
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0328 0.1362
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0146 0.0128
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0023 0.0172 0.0594
Schistosoma mansoni nocturnin 0.0023 0.0172 0.0413
Brugia malayi Bromodomain containing protein 0.0087 0.0823 0.3417
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0023 0.0172 0.0888
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0103 0.0356
Trypanosoma cruzi mitochondrial protein 99, putative 0.0023 0.0172 0.1539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0034 0.0113
Echinococcus granulosus traf and tnf receptor associated protein 0.0023 0.0172 0.0372
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.118 0.3848
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0034 0.0113
Brugia malayi beta-lactamase family protein 0.0039 0.0338 0.1404
Echinococcus multilocularis synaptojanin 1 0.0023 0.0172 0.0155
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0039 0.0337 0.143
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0338 0.084
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0103 0.0922
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0113
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0661 0.1552
Echinococcus multilocularis fk506 binding protein 0.0039 0.0337 0.032
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0173 0.0572
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0172 0.1539
Toxoplasma gondii thioredoxin reductase 0.0048 0.0424 0.3795
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0034 0.0082
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0172 0.1539
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0328 0.1393
Loa Loa (eye worm) beta-lactamase 0.0039 0.0338 0.1118
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0338 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0034 0.0142
Schistosoma mansoni hypothetical protein 0.0171 0.1686 0.4048
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0023 0.0172 0.1539
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.008 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0149 0.1336
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0149 0.0165
Trypanosoma brucei ISWI complex protein 0.0017 0.0111 0.0991
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0103 0.0922
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0222 0.1988
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0244 0.0585
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0172 0.0594
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0545 0.1272
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0036 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0082 0.0735
Brugia malayi CCR4 0.0023 0.0172 0.0715
Plasmodium falciparum importin beta, putative 0.0028 0.0222 0.0767
Schistosoma mansoni ran 0.0021 0.0146 0.035
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0354 0.0337
Schistosoma mansoni importin beta-1 0.0028 0.0222 0.0534
Schistosoma mansoni immunophilin 0.0034 0.0281 0.0675
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2354 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0661 0.5912
Echinococcus granulosus muscleblind protein 0.015 0.1478 0.3522
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0103 0.0356
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.008 0.0339
Onchocerca volvulus 0.0039 0.0338 0.131
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0592 0.142
Leishmania major peptidylprolyl isomerase-like protein 0.0039 0.0337 0.301
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0023 0.0172 0.1539
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0915 0.3887
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0289 0.29 1
Toxoplasma gondii exonuclease III APE 0.0115 0.1119 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0034 0.0142
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0103 0.0356
Schistosoma mansoni cpg binding protein 0.0029 0.023 0.0552
Entamoeba histolytica hypothetical protein 0.0023 0.0168 0.0845
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0172 0.0715
Loa Loa (eye worm) hypothetical protein 0.0019 0.0129 0.0425
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0023 0.0172 0.0731
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0103 0.0922
Echinococcus multilocularis dna polymerase eta 0.0021 0.0149 0.0132
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0168 0.0712
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0565 0.1356
Echinococcus multilocularis traf and tnf receptor associated protein 0.0023 0.0172 0.0155
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0424 0.3795
Brugia malayi beta-lactamase 0.0039 0.0338 0.1404
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0023 0.0172 0.0594
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0146 0.0606
Loa Loa (eye worm) hypothetical protein 0.005 0.0446 0.1475
Echinococcus granulosus dna polymerase eta 0.0021 0.0149 0.0318
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0172 0.0715
Echinococcus multilocularis neutral sphingomyelinase 0.0023 0.0172 0.0155
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0149 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0501 0.1202
Loa Loa (eye worm) hypothetical protein 0.0034 0.0281 0.0929
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0552 0.2291
Brugia malayi mbt repeat family protein 0.0054 0.0488 0.2027
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0338 0.1436
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0592 0.142
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0172 0.0715
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0565 0.1319
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0172 0.1539
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0328 0.1393
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0172 0.1539

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.2809 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 26.1216 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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