Detailed information for compound 1320127

Basic information

Technical information
  • TDR Targets ID: 1320127
  • Name: 6-methoxy-3-(4-methylphenyl)sulfanyl-N-(1-phe nylethyl)-1H-indole-2-carboxamide
  • MW: 416.535 | Formula: C25H24N2O2S
  • H donors: 2 H acceptors: 1 LogP: 5.96 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)[nH]c(c2Sc1ccc(cc1)C)C(=O)NC(c1ccccc1)C
  • InChi: 1S/C25H24N2O2S/c1-16-9-12-20(13-10-16)30-24-21-14-11-19(29-3)15-22(21)27-23(24)25(28)26-17(2)18-7-5-4-6-8-18/h4-15,17,27H,1-3H3,(H,26,28)
  • InChiKey: SEVBOBSFGHQKDC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-methoxy-3-[(4-methylphenyl)thio]-N-(1-phenylethyl)-1H-indole-2-carboxamide
  • NCGC00120164-01
  • E018-2118

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.002 0.005 0.015
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.002 0.005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0043 0.0158 0.0158
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.002 0.005 0.0045
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Onchocerca volvulus 0.0028 0.0088 0.067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0027
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0243 0.5722
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0014 0.0025 0.0504
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.002 0.005 0.005
Echinococcus multilocularis voltage gated potassium channel 0.002 0.005 0.005
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0066 0.0205
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0232 0.0228
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.004 0.014 0.0452
Giardia lamblia Synaptic glycoprotein SC2 0.0014 0.0025 0.1547
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0832 0.3738 0.3738
Loa Loa (eye worm) voltage-gated potassium channel 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0067 0.0264 0.0264
Mycobacterium ulcerans oxidoreductase 0.0016 0.0035 0.0101
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0286 0.126 0.1256
Onchocerca volvulus 0.0043 0.0158 0.1222
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.005 0.005
Plasmodium falciparum epoxide hydrolase 2 0.004 0.014 0.0452
Schistosoma mansoni ap endonuclease 0.0019 0.0048 0.0044
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0158 0.0413
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0158 0.051
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0158 0.0158
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0588 0.0588
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.005 0.1084
Brugia malayi Carboxylesterase family protein 0.0286 0.126 0.1256
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.005 0.0045
Echinococcus granulosus inhibitor of apoptosis protein 0.0031 0.0102 0.0102
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0113 0.0109
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0039 0.0117
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.005 0.005
Echinococcus granulosus caspase 2 0.0014 0.0025 0.0025
Brugia malayi EGF-like domain containing protein 0.0014 0.0025 0.0021
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.005 0.005
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0243 0.07
Brugia malayi Carboxylesterase family protein 0.0286 0.126 0.1256
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.002 0.005 0.0045
Brugia malayi cation channel family protein 0.002 0.005 0.0045
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0165 0.0165
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0038 0.0132 0.0132
Trypanosoma cruzi serine peptidase, putative 0.004 0.014 0.0452
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0014 0.0025 0.007
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0053 0.0053
Echinococcus granulosus carboxylesterase 5A 0.1694 0.7649 0.7649
Echinococcus multilocularis short transient receptor potential channel 6 0.002 0.0053 0.0053
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0048 0.0375
Toxoplasma gondii phospholipase/carboxylesterase 0.004 0.014 0.3257
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.002 0.005 0.005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0235 0.0235
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0243 0.0243
Schistosoma mansoni vesicular amine transporter 0.002 0.005 0.0045
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.002 0.005 0.0361
Brugia malayi beta-lactamase family protein 0.0043 0.0158 0.0154
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0031 0.0102 0.0102
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.005 0.015
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0016 0.0035 0.0101
Echinococcus granulosus two pore calcium channel protein 1 0.002 0.005 0.005
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0267 0.1171 0.3879
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0184 0.0179
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0267 0.1171 0.3879
Echinococcus multilocularis inhibitor of apoptosis protein 0.0031 0.0102 0.0102
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0102 0.0422 0.0422
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0158 0.0413
Echinococcus granulosus ankyrin repeat protein 0.0552 0.2468 0.2468
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0165 0.0161
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.005 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0158 0.051
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0235 0.1028 0.3334
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Echinococcus granulosus sodium channel protein 0.002 0.005 0.005
Brugia malayi hypothetical protein 0.0016 0.0035 0.003
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0158 0.051
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0267 0.1171 1
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0149 0.0149
Echinococcus multilocularis calcium activated potassium channel 0.002 0.005 0.005
Loa Loa (eye worm) amidase 0.0267 0.1171 0.1171
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0016 0.0035 0.0035
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.014 0.0452
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0267 0.1171 0.3879
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Plasmodium falciparum polyprenol reductase, putative 0.0014 0.0025 0.007
Echinococcus granulosus short transient receptor potential channel 6 0.002 0.005 0.005
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.004 0.014 0.3257
Echinococcus multilocularis protein dispatched 1 0.0047 0.0175 0.0175
Echinococcus granulosus potassium voltage gated channel subfamily D 0.002 0.005 0.005
Echinococcus multilocularis sodium channel protein 0.002 0.005 0.005
Plasmodium vivax PST-A protein 0.004 0.014 0.0452
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Schistosoma mansoni transient receptor potential channel 0.002 0.0053 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Schistosoma mansoni integrin beta subunit 0.0259 0.1137 0.1133
Loa Loa (eye worm) hypothetical protein 0.004 0.0143 0.0143
Giardia lamblia Neurogenic locus notch-like protein 0.0014 0.0025 0.1507
Trichomonas vaginalis conserved hypothetical protein 0.004 0.014 0.0452
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0048 0.0145
Brugia malayi hypothetical protein 0.002 0.005 0.0045
Echinococcus multilocularis ryanodine receptor 44f 0.002 0.005 0.005
Echinococcus granulosus transient receptor potential cation channel 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0286 0.126 0.126
Leishmania major hypothetical protein, conserved 0.004 0.014 0.0373
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0016 0.0035 0.0101
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0673 0.3013 1
Schistosoma mansoni caspase-7 (C14 family) 0.0014 0.0025 0.0021
Toxoplasma gondii phospholipase 0.004 0.014 0.3257
Brugia malayi EGF-like domain containing protein 0.0014 0.0025 0.0021
Loa Loa (eye worm) beta-lactamase 0.0043 0.0158 0.0158
Plasmodium vivax PST-A protein 0.004 0.014 0.0452
Mycobacterium tuberculosis Carboxylesterase LipT 0.0286 0.126 0.4113
Echinococcus multilocularis short transient receptor potential channel 6 0.002 0.005 0.005
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0088 0.0088
Schistosoma mansoni voltage-gated cation channel 0.002 0.005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0066
Loa Loa (eye worm) carboxylesterase 0.0286 0.126 0.126
Echinococcus multilocularis two pore calcium channel protein 2 0.002 0.005 0.005
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.002 0.005 0.0045
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0014 0.0025 0.007
Echinococcus granulosus potassium voltage gated channel subfamily D 0.002 0.005 0.005
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.002 0.005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0044 0.0159 0.0159
Echinococcus multilocularis fatty acid amide hydrolase 1 0.2212 1 1
Plasmodium vivax PST-A protein 0.0673 0.3013 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.002 0.005 0.005
Mycobacterium ulcerans dehydrogenase 0.0016 0.0035 0.0101
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.014 0.0452
Giardia lamblia Tenascin-X 0.0014 0.0025 0.1507
Echinococcus granulosus integrin beta 2 0.0326 0.144 0.144
Plasmodium falciparum lysophospholipase, putative 0.0673 0.3013 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.014 0.0452
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0552 0.2468 0.2465
Mycobacterium ulcerans hypothetical protein 0.004 0.014 0.0452
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.014
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0158 0.0158
Loa Loa (eye worm) carboxylesterase 0.0286 0.126 0.126
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.014 0.0452
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0062
Echinococcus multilocularis acetylcholinesterase 0.1694 0.7649 0.7649
Brugia malayi Cell death protein 3 precursor 0.0014 0.0025 0.0021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0031 0.0031
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.002 0.005 0.0045
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0102 0.0422 0.1388
Leishmania major UDP-galactopyranose mutase 0.0016 0.0035 0.0019
Loa Loa (eye worm) calcium channel 0.002 0.005 0.005
Schistosoma mansoni 60S ribosomal protein L21 0.002 0.005 0.0045
Schistosoma mansoni cpg binding protein 0.0028 0.0088 0.0084
Echinococcus multilocularis potassium large conductance calcium activated 0.002 0.005 0.005
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.002 0.005 0.0045
Plasmodium falciparum alpha/beta-hydrolase, putative 0.004 0.014 0.0452
Echinococcus multilocularis shaker cognate 0.002 0.005 0.005
Echinococcus multilocularis adam 0.0014 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0035 0.0121 0.0387
Toxoplasma gondii transporter, cation channel family protein 0.002 0.005 0.1084
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Echinococcus multilocularis para nitrobenzyl esterase 0.0286 0.126 0.126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0191
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0165 0.0165
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0048 0.3214
Toxoplasma gondii exonuclease III APE 0.0019 0.0048 0.1047
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.005 0.005
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.014 0.0452
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0025 0.007
Loa Loa (eye worm) hypothetical protein 0.0286 0.126 0.126
Echinococcus granulosus calcium activated potassium channel 0.002 0.005 0.005
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.004
Brugia malayi Kelch motif family protein 0.0067 0.0264 0.026
Trichomonas vaginalis conserved hypothetical protein 0.004 0.014 0.0452
Plasmodium vivax PST-A protein 0.004 0.014 0.0452
Echinococcus granulosus voltage dependent calcium channel 0.002 0.005 0.005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0048 0.0145
Echinococcus granulosus fatty acid amide hydrolase 1 0.2212 1 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.014 0.0452
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0069 0.0064
Echinococcus multilocularis synaptic glycoprotein sc2 0.0014 0.0025 0.0025
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.002 0.005 0.005
Schistosoma mansoni neuroligin 3 (S09 family) 0.0286 0.126 0.1256
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0158 0.051
Onchocerca volvulus 0.002 0.005 0.0361
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.005 0.005
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0233 0.1016 0.3362
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.014 0.0452
Brugia malayi Transient-receptor-potential like protein 0.002 0.005 0.0045
Brugia malayi amine oxidase, flavin-containing family protein 0.0016 0.0035 0.003
Mycobacterium ulcerans amidase 0.0267 0.1171 0.3879
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Echinococcus multilocularis TRP (transient receptor potential) channel 0.002 0.005 0.005
Leishmania major hypothetical protein, conserved 0.0267 0.1171 0.3829
Trypanosoma cruzi lanosterol synthase, putative 0.0354 0.1566 0.519
Schistosoma mansoni ap endonuclease 0.0019 0.0048 0.0044
Brugia malayi Integrin beta pat-3 precursor 0.0378 0.1676 0.1672
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0184 0.0184
Plasmodium vivax lysophospholipase, putative 0.004 0.014 0.0452
Trypanosoma cruzi ISWI complex protein 0.0015 0.0029 0.0082
Schistosoma mansoni acetylcholinesterase 0.0286 0.126 0.1256
Giardia lamblia High cysteine protein 0.0014 0.0025 0.1507
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0097 0.0399 0.0399
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.005 0.0045
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.002 0.005 0.005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0048 0.0375
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0048 0.0045
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.004 0.004
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0267 0.1171 0.3817
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0062
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Echinococcus granulosus apoptotic protease activating factor 1 0.0014 0.0025 0.0025
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0102 0.0422 0.1388
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0158 0.0413
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0286 0.126 0.1256
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0039 0.0016
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.002 0.005 0.0045
Echinococcus granulosus voltage dependent calcium channel 0.002 0.005 0.005
Brugia malayi ion channel NompC 0.002 0.005 0.0045
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0233 0.1016 0.3362
Mycobacterium ulcerans carboxylesterase, LipT 0.0286 0.126 0.4172
Echinococcus multilocularis voltage gated potassium channel 0.002 0.005 0.005
Trypanosoma brucei ISWI complex protein 0.0015 0.0029 0.0082
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0035
Trypanosoma brucei monoglyceride lipase, putative 0.0673 0.3013 1
Brugia malayi hypothetical protein 0.0014 0.0025 0.0021
Onchocerca volvulus 0.0043 0.0158 0.1222
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.004 0.014 0.014
Echinococcus multilocularis 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0102
Echinococcus granulosus voltage gated potassium channel 0.002 0.005 0.005
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.002 0.005 0.005
Leishmania major lanosterol synthase, putative 0.0354 0.1566 0.515
Plasmodium vivax unspecified product 0.004 0.014 0.0452
Onchocerca volvulus 0.0014 0.0025 0.0164
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0102 0.0422 1
Onchocerca volvulus Huntingtin homolog 0.0121 0.0509 0.4022
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Leishmania major hypothetical protein, conserved 0.004 0.014 0.0373
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Echinococcus multilocularis transient receptor potential cation channel 0.0573 0.2561 0.2561
Echinococcus granulosus zinc finger protein 0.0021 0.0055 0.0055
Giardia lamblia Neurogenic locus Notch protein precursor 0.0014 0.0025 0.1507
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0014 0.0025 0.0068
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Onchocerca volvulus Huntingtin homolog 0.0121 0.0509 0.4022
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0035 0.0101
Brugia malayi CHE-14 protein 0.0041 0.0149 0.0144
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0138
Echinococcus multilocularis sodium leak channel non selective protein 0.002 0.005 0.005
Echinococcus granulosus potassium voltage gated channel subfamily C 0.002 0.005 0.005
Trypanosoma cruzi serine peptidase, putative 0.004 0.014 0.0452
Onchocerca volvulus 0.0286 0.126 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0158 0.0158
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0066 0.0205
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.002 0.005 0.005
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.014
Mycobacterium tuberculosis Conserved protein 0.0043 0.0158 0.0413
Plasmodium vivax hypothetical protein, conserved 0.004 0.014 0.0452
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.005 0.0045
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0014 0.0025 0.0021
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.004 0.014 0.0373
Brugia malayi Amidase family protein 0.0267 0.1171 0.1168
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.004 0.014 0.0452
Chlamydia trachomatis protoporphyrinogen oxidase 0.0016 0.0035 0.0261
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.002 0.005 0.0045
Echinococcus multilocularis acetylcholinesterase 0.1694 0.7649 0.7649
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0066 0.0205
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.005 0.005
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0031 0.0102 0.0097
Onchocerca volvulus 0.0016 0.0035 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.004 0.014 0.0452
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0102 0.0422 0.1388
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0014 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Toxoplasma gondii hypothetical protein 0.002 0.005 0.1084
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.005 0.005
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.005 0.0045
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0004 0.0004
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0216 0.0941 0.3045
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0158 0.0158
Echinococcus multilocularis voltage gated hydrogen channel 1 0.002 0.005 0.005
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.002 0.005 0.005
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0158 0.051
Loa Loa (eye worm) amidase 0.0267 0.1171 0.1171
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0004 0.00000043047
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.002 0.005 0.005
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.1694 0.7649 0.7649
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0048 0.0145
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0158 0.0413
Giardia lamblia Cgi67 serine protease precursor-like protein 0.004 0.014 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.005 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.004 0.0035
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0014 0.0025 0.007
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.014 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0025 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0673 0.3013 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.014 0.0452
Loa Loa (eye worm) hypothetical protein 0.0034 0.0113 0.0113
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0053 0.0053
Plasmodium falciparum esterase, putative 0.004 0.014 0.0452
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0149 0.0149
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0243 0.0243
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0102 0.0422 0.1388
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0243 0.0239
Echinococcus granulosus transient receptor potential cation channel 0.002 0.005 0.005
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0138
Onchocerca volvulus 0.0031 0.0102 0.0776
Mycobacterium ulcerans hydrolase 0.004 0.014 0.0452
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0267 0.1171 0.3817
Schistosoma mansoni transient receptor potential channel 4 0.002 0.005 0.0045
Plasmodium falciparum lysophospholipase, putative 0.004 0.014 0.0452
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.002 0.005 0.0361
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0184 0.0179
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0399 0.0395
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0035
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0399 0.1313
Schistosoma mansoni amine oxidase 0.0016 0.0035 0.003
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.002 0.005 0.005
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0037 0.0033
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0066 0.0124
Leishmania major monoglyceride lipase, putative 0.0673 0.3013 1
Echinococcus granulosus voltage gated hydrogen channel 1 0.002 0.005 0.005
Schistosoma mansoni ryanodine receptor related 0.002 0.005 0.0045
Entamoeba histolytica ;Alias 0.004 0.014 0.0452
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0158 0.0413
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0158 0.0154
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0066 0.0205
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.004 0.014 0.3257
Trichomonas vaginalis spcc417.12 protein, putative 0.0286 0.126 0.4172
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.005 0.005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0066 0.0205
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0016 0.0035 0.0101
Echinococcus granulosus TRP transient receptor potential channel 0.002 0.005 0.005
Plasmodium vivax PST-A protein 0.004 0.014 0.0452
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0048 0.0064
Plasmodium falciparum exported lipase 1 0.004 0.014 0.0452
Schistosoma mansoni cpg binding protein 0.0032 0.0104 0.01
Echinococcus granulosus cpg binding protein 0.0032 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0027
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.005 0.015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Brugia malayi EGF-like domain containing protein 0.0014 0.0025 0.0021
Echinococcus multilocularis cpg binding protein 0.0032 0.0104 0.0104
Trypanosoma cruzi monoglyceride lipase, putative 0.0673 0.3013 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0037 0.0033
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0014 0.0025 0.007
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0014 0.0025 0.0021
Echinococcus granulosus expressed conserved protein 0.0091 0.0373 0.0373
Echinococcus granulosus short transient receptor potential channel 6 0.002 0.0053 0.0053
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.014 0.0452
Schistosoma mansoni zinc finger protein 0.0021 0.0055 0.0051
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.005 0.005
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0102 0.0422 0.1317
Schistosoma mansoni hypothetical protein 0.002 0.005 0.0045
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0066 0.0205
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0027
Brugia malayi MGC79044 protein 0.004 0.014 0.0136
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0069 0.0069
Echinococcus multilocularis voltage dependent calcium channel 0.002 0.005 0.005
Echinococcus multilocularis protein jagged 2 0.0014 0.0025 0.0025
Mycobacterium ulcerans peptide amidase, GatA 0.0267 0.1171 0.3879
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0039 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0165 0.0161
Loa Loa (eye worm) hypothetical protein 0.0286 0.126 0.126
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0267 0.1171 0.3879
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0158 0.051
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1221 0.3984
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0673 0.3013 1
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Trypanosoma cruzi amidase, putative 0.0267 0.1171 0.3879
Echinococcus granulosus adam 0.0014 0.0025 0.0025
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0267 0.1171 0.3817
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0031 0.0102 0.0097
Plasmodium falciparum lysophospholipase, putative 0.0673 0.3013 1
Loa Loa (eye worm) integrin beta-2 0.0378 0.1676 0.1676
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Brugia malayi Protein C20orf22 0.004 0.014 0.0136
Schistosoma mansoni calcium-activated potassium channel 0.002 0.005 0.0045
Trypanosoma cruzi ISWI complex protein 0.0015 0.0029 0.0082
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0037 0.0037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0048 0.0145
Echinococcus granulosus para nitrobenzyl esterase 0.0286 0.126 0.126
Schistosoma mansoni hypothetical protein 0.0402 0.1783 0.178
Toxoplasma gondii peptidase S15, putative 0.004 0.014 0.3257
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0053 0.0053
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0158 0.0413
Echinococcus granulosus Phospholipase carboxylesterase 0.004 0.014 0.014
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.014 0.0452
Giardia lamblia High cysteine protein 0.0014 0.0025 0.1507
Mycobacterium ulcerans hypothetical protein 0.0043 0.0158 0.051
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0286 0.126 0.4113
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.014
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.002 0.005 0.0045
Schistosoma mansoni cpg binding protein 0.0032 0.0104 0.01
Schistosoma mansoni inhibitor of apoptosis protein 0.0031 0.0102 0.0097
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0035 0.0101
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0048 0.0145
Echinococcus granulosus replication factor c subunit 1 0.001 0.0004 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0138
Giardia lamblia Tenascin-like 0.0014 0.0025 0.1507
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0004 0.00000043047
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0031 0.0027
Leishmania major hypothetical protein, conserved 0.002 0.005 0.0069
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0031 0.0102 0.0097
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.005 0.005
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0066 0.0205
Trichomonas vaginalis esterase, putative 0.0043 0.0158 0.051
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.002 0.005 0.0045
Toxoplasma gondii hypothetical protein 0.004 0.014 0.3257
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.005 0.005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0214 0.5009
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0399 0.0399
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0031 0.0031
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0066 0.0205
Toxoplasma gondii protein c14orf29, putative 0.004 0.014 0.3257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0165 0.0161
Onchocerca volvulus 0.0043 0.0158 0.1222
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0066 0.0205
Schistosoma mansoni patched 1 0.0041 0.0149 0.0144
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0243 0.0794
Loa Loa (eye worm) voltage-gated calcium channel 0.002 0.005 0.005
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0267 0.1171 1
Toxoplasma gondii transporter, cation channel family protein 0.002 0.005 0.1084
Plasmodium falciparum lysophospholipase, putative 0.004 0.014 0.0452
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0158 0.0413
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0399 0.0399
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0158 0.051
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.004 0.004
Onchocerca volvulus Cell death protein 3 homolog 0.0014 0.0025 0.0164
Mycobacterium tuberculosis Conserved protein 0.0043 0.0158 0.0413
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0014 0.0025 0.007
Brugia malayi Carboxylesterase family protein 0.0286 0.126 0.1256
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0102 0.0422 0.1388
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.004 0.014 0.0452
Loa Loa (eye worm) hypothetical protein 0.0286 0.126 0.126
Giardia lamblia Tenascin-37 0.0014 0.0025 0.1507
Plasmodium falciparum lysophospholipase, putative 0.0673 0.3013 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0277 0.0277
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Echinococcus granulosus neuroligin 0.0286 0.126 0.126
Loa Loa (eye worm) hypothetical protein 0.0286 0.126 0.126
Brugia malayi Carboxylesterase family protein 0.1694 0.7649 0.7648
Echinococcus granulosus acetylcholinesterase 0.1694 0.7649 0.7649
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.002 0.005 0.005
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0286 0.126 0.126
Brugia malayi voltage-dependent calcium channel 0.002 0.005 0.0045
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.004 0.014 0.0452
Entamoeba histolytica hypothetical protein 0.0035 0.0121 0.0387
Mycobacterium ulcerans amidase 0.0267 0.1171 0.3879
Trichomonas vaginalis conserved hypothetical protein 0.0673 0.3013 1
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0267 0.1171 0.3879
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.004 0.014 0.0452
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0243 0.0794
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.005 0.005
Plasmodium falciparum BEM46-like protein, putative 0.004 0.014 0.0452
Plasmodium falciparum esterase, putative 0.0673 0.3013 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0158 0.051
Brugia malayi beta-lactamase 0.0043 0.0158 0.0154
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0048 0.0145
Mycobacterium ulcerans amidase 0.0267 0.1171 0.3879
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.005 0.005
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0008 0.0004
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0138
Echinococcus multilocularis ankyrin repeat protein 0.0552 0.2468 0.2468
Echinococcus granulosus potassium voltage gated channel subfamily A 0.002 0.005 0.005
Brugia malayi PHD-finger family protein 0.0026 0.0079 0.0075
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0286 0.126 0.126
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Echinococcus granulosus fibrillin 1 0.0014 0.0025 0.0025
Echinococcus multilocularis fatty acid amide hydrolase 1 0.2212 1 1
Echinococcus granulosus potassium large conductance calcium activated 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0102
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0031 0.0031
Brugia malayi MGC83647 protein 0.004 0.014 0.0136
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Echinococcus granulosus GPCR family 2 0.0016 0.0031 0.0031
Mycobacterium ulcerans lipase LipD 0.0043 0.0158 0.051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0121 0.0509 0.0509
Entamoeba histolytica hypothetical protein 0.0035 0.0121 0.0387
Mycobacterium ulcerans hypothetical protein 0.0673 0.3013 1
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Mycobacterium leprae Probable lipase LipE 0.0043 0.0158 0.051
Chlamydia trachomatis hydrolase 0.004 0.014 0.1166
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0267 0.1171 0.1168
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0014 0.0025 0.007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0184 0.0184
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.002 0.005 0.0045
Mycobacterium tuberculosis Conserved protein 0.0043 0.0158 0.0413
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0027
Mycobacterium ulcerans hypothetical protein 0.004 0.014 0.0452
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0158 0.051
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.005 0.005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0048 0.0145
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0267 0.1171 0.3817
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.005 0.1084
Toxoplasma gondii hypothetical protein 0.0014 0.0025 0.0491
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0014 0.0025 0.007
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.004 0.014 0.0452
Mycobacterium ulcerans lysophospholipase 0.0673 0.3013 1
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.005 0.005
Echinococcus granulosus hypothetical protein 0.002 0.005 0.005
Echinococcus granulosus shaker cognate 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.004 0.014 0.0452
Entamoeba histolytica hypothetical protein 0.0014 0.0025 0.007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0158 0.0158
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0014 0.0025 0.007
Brugia malayi Carboxylesterase family protein 0.1694 0.7649 0.7648
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.005 0.0045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.004 0.014 0.0452
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Schistosoma mansoni transient receptor potential channel 0.002 0.005 0.0045
Leishmania major hypothetical protein, conserved 0.0043 0.0158 0.0432
Echinococcus multilocularis voltage dependent calcium channel 0.002 0.005 0.005
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.005 0.0045
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0031 0.0031
Brugia malayi cation channel family protein 0.002 0.005 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0035 0.0001
Schistosoma mansoni hypothetical protein 0.002 0.0053 0.0049
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.005 0.0045
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0048 0.0048
Loa Loa (eye worm) voltage-gated potassium channel 0.002 0.005 0.005
Schistosoma mansoni peptidase 0.004 0.014 0.0136
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.002 0.005 0.005
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.014 0.0452
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0031 0.0031
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0016 0.0035 0.0101
Brugia malayi hypothetical protein 0.0035 0.0121 0.0117
Entamoeba histolytica hypothetical protein 0.004 0.014 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.004 0.014 0.0452
Schistosoma mansoni hypothetical protein 0.0035 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0034 0.0113 0.0109
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.002 0.005 0.0045
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.002 0.005 0.0045
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.002 0.005 0.005
Toxoplasma gondii hypothetical protein 0.002 0.005 0.1084
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0158 0.0154
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.005 0.005
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0673 0.3013 1
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.004 0.014 0.0452
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0066 0.0205
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0673 0.3013 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0286 0.126 0.4172
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0267 0.1171 0.1171
Onchocerca volvulus 0.0014 0.0025 0.0168
Echinococcus multilocularis neuroligin 0.0286 0.126 0.126
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0267 0.1171 0.3817
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Echinococcus multilocularis fibrillin 1 0.0014 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Schistosoma mansoni inositol 145-trisphosphate receptor 0.002 0.005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0031 0.0102 0.0102
Echinococcus granulosus BC026374 protein S09 family 0.0286 0.126 0.126
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.002 0.005 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0121 0.0121
Plasmodium falciparum prodrug activation and resistance esterase 0.004 0.014 0.0452
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0039 0.0301
Leishmania major calcium channel protein, putative,ion transporter, putative 0.002 0.005 0.0069
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0066 0.0105
Onchocerca volvulus 0.0286 0.126 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.2212 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.1783 0.1783
Toxoplasma gondii hypothetical protein 0.004 0.014 0.3257
Echinococcus granulosus voltage gated potassium channel 0.002 0.005 0.005
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0149 0.0149
Chlamydia trachomatis acyltransferase family protein 0.004 0.014 0.1166
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0048 0.0048
Echinococcus granulosus abhydrolase domain containing protein 13 0.004 0.014 0.014
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.002 0.005 0.005
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0062
Mycobacterium ulcerans beta-lactamase 0.0043 0.0158 0.051
Echinococcus granulosus acetylcholinesterase 0.1694 0.7649 0.7649
Plasmodium vivax hypothetical protein, conserved 0.004 0.014 0.0452
Brugia malayi beta-lactamase family protein 0.0043 0.0158 0.0154
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0243 0.0794
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0014 0.0025 0.0025
Brugia malayi EGF-like domain containing protein 0.0014 0.0025 0.0021
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.005 0.005
Echinococcus multilocularis conserved hypothetical protein 0.002 0.005 0.005
Onchocerca volvulus 0.0023 0.0066 0.0492
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0016 0.0035 0.003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0035
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0053
Loa Loa (eye worm) carboxylesterase 0.1694 0.7649 0.7649
Echinococcus granulosus transient receptor potential cation channel 0.0572 0.2557 0.2557
Loa Loa (eye worm) hypothetical protein 0.0041 0.0149 0.0149
Loa Loa (eye worm) acetylcholinesterase 1 0.1694 0.7649 0.7649
Brugia malayi putative amidase 0.0267 0.1171 0.1168
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0014 0.0025 0.007
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Echinococcus multilocularis abhydrolase domain containing 3 0.004 0.014 0.014
Echinococcus granulosus lysine specific histone demethylase 1A 0.0016 0.0035 0.0035
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.005 0.005
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.014 0.0452
Toxoplasma gondii hypothetical protein 0.004 0.014 0.3257
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.004 0.014 0.0136
Plasmodium falciparum exported lipase 2 0.004 0.014 0.0452
Mycobacterium ulcerans amidase 0.0267 0.1171 0.3879
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0267 0.1171 0.3879
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0004 0.0000031005
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.1694 0.7649 0.7649
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Echinococcus granulosus sodium leak channel non selective protein 0.002 0.005 0.005
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0158 0.051
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.005 0.0045
Schistosoma mansoni hypothetical protein 0.0015 0.0029 0.0025
Brugia malayi Cyclic-nucleotide gated cation channel 0.002 0.005 0.0045
Onchocerca volvulus 0.0014 0.0025 0.0163
Plasmodium falciparum protoporphyrinogen oxidase 0.0016 0.0035 0.0101
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.005 0.0045
Brugia malayi olfactory channel protein osm-9 0.002 0.0053 0.0049
Onchocerca volvulus Deterin homolog 0.0031 0.0102 0.0776
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0004 0.00000043047
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Echinococcus multilocularis two pore calcium channel protein 1 0.002 0.005 0.005
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.002 0.005 0.015
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0102 0.0422 0.0418
Trichomonas vaginalis conserved hypothetical protein 0.004 0.014 0.0452
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.014 0.0452
Echinococcus multilocularis transfer RNA-Gly 0.002 0.005 0.005
Trypanosoma brucei monoglyceride lipase, putative 0.0673 0.3013 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.0016 0.0035 0.0035
Giardia lamblia Tenascin precursor 0.0014 0.0025 0.1507
Brugia malayi hypothetical protein 0.0286 0.126 0.1256
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0066 0.0124
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.002 0.005 0.015
Trypanosoma cruzi UDP-galactopyranose mutase 0.0016 0.0035 0.0101
Toxoplasma gondii transporter, cation channel family protein 0.002 0.005 0.1084
Plasmodium vivax alpha/beta hydrolase, putative 0.004 0.014 0.0452
Schistosoma mansoni zinc finger protein 0.0015 0.0029 0.0025
Echinococcus multilocularis apoptotic protease activating factor 1 0.0014 0.0025 0.0025
Echinococcus granulosus dnaJ subfamily B 0.0402 0.1783 0.1783
Brugia malayi SWIRM domain containing protein 0.0016 0.0035 0.003
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0673 0.3013 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.002 0.005 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0149 0.048
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0121 0.0117
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0406 0.0402
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0158 0.0154
Schistosoma mansoni BC026374 protein (S09 family) 0.0286 0.126 0.1256
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.005 0.005
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0066 0.0124
Plasmodium vivax polyprenol reductase, putative 0.0014 0.0025 0.007
Giardia lamblia hypothetical protein 0.0014 0.0025 0.1507
Loa Loa (eye worm) hypothetical protein 0.0121 0.0509 0.0509
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0158 0.0158
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0016 0.0035 0.0101
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.004 0.014 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0165 0.0161
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Loa Loa (eye worm) ryanodine receptor 0.002 0.005 0.005
Echinococcus multilocularis nibrin 0.001 0.0004 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0158 0.051
Schistosoma mansoni amidase 0.2212 1 1
Echinococcus multilocularis fibrillin 2 0.0014 0.0025 0.0025
Schistosoma mansoni fatty-acid amide hydrolase 0.2212 1 1
Schistosoma mansoni two-pore calcium channel 0.002 0.005 0.0045
Mycobacterium ulcerans amidase 0.0267 0.1171 0.3879
Echinococcus multilocularis GPCR, family 2 0.0016 0.0031 0.0031
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.002 0.005 0.015
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Trypanosoma cruzi UDP-galactopyranose mutase 0.0016 0.0035 0.0101
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0066 0.0105
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.004 0.014 0.0452
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0267 0.1171 0.1171
Plasmodium falciparum esterase, putative 0.004 0.014 0.0452
Trypanosoma brucei lanosterol synthase 0.0354 0.1566 0.519
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0066 0.0205
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0048 0.0145
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.005 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0035 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0066 0.0205
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0673 0.3013 1
Echinococcus granulosus transient receptor potential cation channel 0.002 0.005 0.005
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0673 0.3013 1
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0067 0.0264 0.0264
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0048 0.0048
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.014 0.0452
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0267 0.1171 1
Mycobacterium tuberculosis Possible lysophospholipase 0.0673 0.3013 1
Schistosoma mansoni gliotactin 0.0286 0.126 0.1256
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Echinococcus granulosus abhydrolase domain containing 3 0.004 0.014 0.014
Onchocerca volvulus 0.0286 0.126 1
Echinococcus multilocularis integrin beta 2 0.0326 0.144 0.144
Plasmodium vivax lysophospholipase, putative 0.004 0.014 0.0452
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.002 0.005 0.0045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0014 0.0025 0.0021
Schistosoma mansoni voltage-dependent calcium channel 0.002 0.005 0.0045
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.014 0.0452
Mycobacterium ulcerans hypothetical protein 0.0023 0.0066 0.0205
Loa Loa (eye worm) voltage-dependent calcium channel 0.002 0.005 0.005
Plasmodium vivax lysophospholipase, putative 0.004 0.014 0.0452
Plasmodium vivax PST-A protein 0.004 0.014 0.0452
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.005 0.005
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0149 0.0149
Echinococcus granulosus fatty acid amide hydrolase 1 0.2212 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0286 0.126 0.126
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0037 0.0037
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.002 0.005 0.005
Loa Loa (eye worm) ion channel NompC 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Schistosoma mansoni voltage-gated ion channel 0.002 0.005 0.0045
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0031 0.0102 0.0097
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0035 0.0001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0158 0.0158
Echinococcus multilocularis zinc finger protein 0.0021 0.0055 0.0055
Echinococcus granulosus ryanodine receptor 44f 0.002 0.005 0.005
Brugia malayi Bromodomain containing protein 0.0038 0.0132 0.0128
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0014 0.0025 0.0504
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.002 0.005 0.0045
Echinococcus multilocularis carboxylesterase 5A 0.1694 0.7649 0.7649
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0588 0.0588
Echinococcus multilocularis transient receptor potential gamma protein 0.002 0.005 0.005
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.002 0.005 0.0045
Trichomonas vaginalis hypothetical protein 0.0014 0.0025 0.0068
Mycobacterium ulcerans monoamine oxidase 0.0016 0.0035 0.0101
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0018 0.0043 0.0916
Toxoplasma gondii histone lysine-specific demethylase 0.0016 0.0035 0.0729
Echinococcus granulosus transient receptor potential cation channel 0.002 0.005 0.005
Onchocerca volvulus 0.0286 0.126 1
Trypanosoma cruzi lanosterol synthase, putative 0.0354 0.1566 0.519
Brugia malayi hypothetical protein 0.0121 0.0509 0.0505
Echinococcus granulosus nibrin 0.001 0.0004 0.0004
Schistosoma mansoni transient receptor potential channel 0.002 0.005 0.0045
Echinococcus multilocularis expressed conserved protein 0.0091 0.0373 0.0373
Echinococcus granulosus potassium voltage gated channel subfamily D 0.002 0.005 0.005
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.002 0.005 0.0045
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0048 0.0145
Brugia malayi CXXC zinc finger family protein 0.0028 0.0088 0.0084
Echinococcus multilocularis caspase 2 0.0014 0.0025 0.0025
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.014 0.0452
Brugia malayi Bromodomain containing protein 0.0076 0.0304 0.0299
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Entamoeba histolytica hypothetical protein 0.0035 0.0121 0.0387
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0102 0.0422 0.1388
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0004 0.00000012957
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Plasmodium vivax alpha/beta hydrolase, putative 0.004 0.014 0.0452
Entamoeba histolytica hypothetical protein 0.004 0.014 0.0452
Brugia malayi Carboxylesterase family protein 0.0286 0.126 0.1256
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0673 0.3013 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0286 0.126 0.126
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0014 0.0025 0.007
Echinococcus multilocularis Phospholipase carboxylesterase 0.004 0.014 0.014
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1694 0.7649 0.7648
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.014 0.0452
Echinococcus granulosus synaptic glycoprotein sc2 0.0014 0.0025 0.0025
Onchocerca volvulus 0.0286 0.126 1
Plasmodium vivax unspecified product 0.004 0.014 0.0452
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0004 0.00000043047
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.014
Toxoplasma gondii ABC1 family protein 0.0043 0.0158 0.3674
Echinococcus granulosus fibrillin 2 0.0014 0.0025 0.0025
Echinococcus granulosus fatty acid amide hydrolase 1 0.0267 0.1171 0.1171
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0066
Schistosoma mansoni bromodomain containing protein 0.0064 0.0251 0.0247
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0286 0.126 0.4113
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0102 0.0422 0.1388
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0048 0.0044
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0016 0.0035 0.003
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0673 0.3013 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0286 0.126 0.1256
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0035 0.0001
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.004 0.014 0.3257
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.014 0.0452
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0165 0.0165
Trypanosoma cruzi amidase, putative 0.0267 0.1171 0.3879
Loa Loa (eye worm) hypothetical protein 0.0043 0.0158 0.0158
Echinococcus granulosus transient receptor potential gamma protein 0.002 0.005 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0158 0.051
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0243 0.0239
Echinococcus granulosus monoacylglycerol lipase abhd12 0.004 0.014 0.014
Mycobacterium ulcerans hypothetical protein 0.0102 0.0422 0.1388
Echinococcus granulosus two pore calcium channel protein 2 0.002 0.005 0.005
Schistosoma mansoni amine oxidase 0.0016 0.0035 0.003
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0243 0.0718
Echinococcus granulosus lysine specific histone demethylase 1A 0.0016 0.0035 0.0035
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0016 0.0035 0.0101
Brugia malayi hypothetical protein 0.0067 0.0264 0.026
Echinococcus multilocularis BC026374 protein (S09 family) 0.0286 0.126 0.126
Echinococcus multilocularis protein patched 0.0041 0.0149 0.0149
Leishmania major hypothetical protein, unknown function 0.002 0.005 0.0069
Schistosoma mansoni fatty-acid amide hydrolase 0.0267 0.1171 0.1168
Schistosoma mansoni voltage-gated potassium channel 0.002 0.005 0.0045
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.002 0.005 0.005
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0039 0.0117
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.002 0.005 0.005
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0031 0.0027
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.014 0.0355
Brugia malayi Amidase family protein 0.0267 0.1171 0.1168
Brugia malayi Synaptic glycoprotein SC2 0.0014 0.0025 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.004 0.0035
Toxoplasma gondii hypothetical protein 0.004 0.014 0.3257
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0267 0.1171 0.1171

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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