Detailed information for compound 1336815

Basic information

Technical information
  • TDR Targets ID: 1336815
  • Name: 3-(5-chloro-2-methylphenyl)-1-(furan-2-ylmeth yl)-1-(3-morpholin-4-ylpropyl)thiourea
  • MW: 407.957 | Formula: C20H26ClN3O2S
  • H donors: 0 H acceptors: 0 LogP: 3.75 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)N=C(N(Cc1ccco1)CCCN1CCOCC1)S)C
  • InChi: 1S/C20H26ClN3O2S/c1-16-5-6-17(21)14-19(16)22-20(27)24(15-18-4-2-11-26-18)8-3-7-23-9-12-25-13-10-23/h2,4-6,11,14H,3,7-10,12-13,15H2,1H3,(H,22,27)
  • InChiKey: GGVYVSNOXGCGSJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(5-chloro-2-methyl-phenyl)-1-(2-furylmethyl)-1-(3-morpholinopropyl)thiourea
  • 3-(5-chloro-2-methylphenyl)-1-(2-furylmethyl)-1-(3-morpholinopropyl)thiourea
  • 3-(5-chloro-2-methyl-phenyl)-1-(furan-2-ylmethyl)-1-(3-morpholin-4-ylpropyl)thiourea
  • MLS000729640
  • N'-(5-chloro-2-methylphenyl)-N-(2-furylmethyl)-N-(3-morpholin-4-ylpropyl)thiourea
  • SMR000307917

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cyclin dependent kinase 5 0.0049 0.0517 0.0516
Giardia lamblia Hypothetical protein 0.0022 0.0156 0.0372
Trypanosoma brucei cAMP binding protein, putative 0.0013 0.0027 0.0103
Echinococcus granulosus voltage gated potassium channel 0.0016 0.0077 0.0076
Onchocerca volvulus 0.0031 0.0279 0.0647
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0002
Schistosoma mansoni topbp1 0.0011 0.0002 0.0002
Schistosoma mansoni cyclin l 0.0022 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0016 0.0065 0.0065
Echinococcus multilocularis geminin 0.0186 0.2348 0.2347
Echinococcus granulosus cyclin G2 0.0022 0.0156 0.0155
Echinococcus granulosus GPCR family 2 0.0017 0.0089 0.0088
Echinococcus granulosus nibrin 0.0011 0.0002 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0156 0.0372
Loa Loa (eye worm) hypoxia-induced factor 1 0.0165 0.207 0.4814
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0512 0.0512
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0025 0.006
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.0156 0.0361
Schistosoma mansoni cpg binding protein 0.0031 0.0279 0.0279
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0148 0.0343
Brugia malayi Protein kinase domain containing protein 0.002 0.0125 0.0288
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0156 0.0361
Brugia malayi hypothetical protein 0.0331 0.4299 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0049 0.0517 0.0516
Echinococcus granulosus cpg binding protein 0.0033 0.0303 0.0302
Trichomonas vaginalis cyclin A, putative 0.0194 0.2465 0.5933
Brugia malayi MH2 domain containing protein 0.0131 0.1612 0.3748
Loa Loa (eye worm) hypothetical protein 0.0134 0.1658 0.3855
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0401 0.1619
Echinococcus granulosus Chromo domain 0.0012 0.0025 0.0024
Trypanosoma brucei protein kinase, putative 0.0159 0.1988 0.8064
Giardia lamblia Kinase, CMGC GSK 0.0159 0.1988 0.4784
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.039
Echinococcus multilocularis cyclin A3 4 0.0022 0.0156 0.0155
Schistosoma mansoni cpg binding protein 0.0033 0.0303 0.0303
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0098 0.039
Brugia malayi Egg laying defective protein 4 0.0012 0.0024 0.0054
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0148 0.0353
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0025 0.0025
Echinococcus granulosus tumor protein p63 0.037 0.4824 0.4823
Loa Loa (eye worm) hypothetical protein 0.0022 0.0148 0.0343
Echinococcus granulosus serine:threonine protein kinase N2 0.002 0.0125 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.144 0.144
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0013 0.0028 0.0026
Schistosoma mansoni cyclin G2 0.0022 0.0156 0.0156
Mycobacterium leprae Possible regulatory protein 0.0014 0.0043 0.021
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0013 0.0028 0.0026
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0305 0.0304
Echinococcus granulosus Protein kinase C brain isozyme 0.0118 0.144 0.1439
Echinococcus granulosus hyperpolarization activated cyclic 0.0013 0.0028 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0517 0.0517
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0134 0.0317
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0098 0.1178 0.1177
Brugia malayi Thioredoxin reductase 0.0052 0.0552 0.1282
Echinococcus multilocularis Rac GTPase activating protein 1 0.0013 0.0027 0.0026
Schistosoma mansoni hypothetical protein 0.0448 0.5869 0.5869
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.0065 0.0168
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0025 0.0125
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0025 0.0055
Brugia malayi p70 ribosomal S6 kinase beta 0.002 0.0125 0.0288
Entamoeba histolytica protein kinase domain containing protein 0.0159 0.1988 0.4787
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0552 0.0551
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.002 0.0125 0.0288
Loa Loa (eye worm) hypothetical protein 0.0041 0.0401 0.093
Entamoeba histolytica cyclin family protein 0.0092 0.1096 0.264
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0358 0.083
Loa Loa (eye worm) hypothetical protein 0.0022 0.0153 0.0354
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0089 0.0204
Echinococcus granulosus intermediate filament protein 0.003 0.0254 0.0252
Echinococcus granulosus cyclins 0.0092 0.1096 0.1095
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0016 0.0065 0.0324
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0922 0.2142
Echinococcus multilocularis musashi 0.003 0.0254 0.0252
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.039
Onchocerca volvulus 0.0194 0.2465 0.5732
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0025 0.0055
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0016 0.0065 0.0324
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0305 0.0304
Brugia malayi cell division control protein 2 homolog 0.0049 0.0517 0.12
Brugia malayi N-terminal motif family protein 0.0223 0.2854 0.6637
Entamoeba histolytica hypothetical protein 0.0013 0.0027 0.0066
Echinococcus multilocularis cyclin B3 1 0.0092 0.1096 0.1095
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0043 0.0099
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.002 0.0125 0.0124
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0098 0.0493
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.4153 1
Trichomonas vaginalis AGC family protein kinase 0.002 0.0125 0.0296
Echinococcus multilocularis serine:threonine protein kinase N2 0.002 0.0125 0.0124
Loa Loa (eye worm) hypothetical protein 0.0134 0.1658 0.3855
Onchocerca volvulus 0.0013 0.0027 0.0061
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0013 0.0028 0.0026
Echinococcus multilocularis N chimaerin 0.0013 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0061
Onchocerca volvulus 0.0054 0.0584 0.1356
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0043 0.0419
Schistosoma mansoni ets-related 0.0012 0.0012 0.0012
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0012 0.0012 0.001
Echinococcus multilocularis tumor protein p63 0.037 0.4824 0.4823
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0043 0.0099
Entamoeba histolytica diacylglycerol kinase, putative 0.0013 0.0027 0.0066
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0194 0.0449
Trypanosoma brucei mitotic cyclin 0.0022 0.0156 0.0627
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0018 0.0093 0.0219
Trichomonas vaginalis cyclins, putative 0.0092 0.1096 0.2636
Schistosoma mansoni gabp alpha 0.0079 0.0922 0.0922
Brugia malayi Protein kinase domain containing protein 0.002 0.0125 0.0288
Echinococcus multilocularis cyclin G2 0.0022 0.0156 0.0155
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0148 0.0353
Trichomonas vaginalis AGC family protein kinase 0.002 0.0125 0.0296
Echinococcus multilocularis cyclins 0.0092 0.1096 0.1095
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.1956 1
Schistosoma mansoni hypothetical protein 0.0017 0.0089 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0025 0.0055
Echinococcus granulosus ETS domain containing protein Elk 1 0.0012 0.0012 0.001
Loa Loa (eye worm) cyclin domain-containing protein 0.0214 0.2731 0.6352
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0157
Schistosoma mansoni protein kinase C 0.0015 0.0063 0.0063
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0194 0.078
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0159 0.1988 0.8047
Toxoplasma gondii diacylglycerol kinase, putative 0.0013 0.0027 0.0137
Loa Loa (eye worm) hypothetical protein 0.0083 0.0967 0.2248
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0022 0.0156 0.0155
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0015 0.0063 0.0062
Treponema pallidum ATP-dependent DNA helicase 0.0011 0.0006 0.0009
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0148 0.0738
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0012 0.0012 0.0012
Echinococcus granulosus ETS transcription factor Elf 5 0.0012 0.0012 0.001
Echinococcus granulosus Ankyrin 0.0016 0.007 0.0069
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0075 0.0298
Plasmodium falciparum protein kinase 5 0.0049 0.0517 0.2593
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.0156 0.0361
Entamoeba histolytica hypothetical protein 0.0022 0.0156 0.0376
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0134 0.0317
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0016 0.0065 0.0324
Giardia lamblia Hypothetical protein 0.0022 0.0156 0.0372
Leishmania major mitotic cyclin, putative 0.0022 0.0156 0.0541
Brugia malayi diacylglycerol kinase 0.0013 0.0027 0.0061
Schistosoma mansoni intermediate filament proteins 0.003 0.0254 0.0254
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0024 0.0023
Trichomonas vaginalis cyclin B, putative 0.0194 0.2465 0.5933
Leishmania major trypanothione reductase 0.0052 0.0552 0.2163
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0462 0.1073
Leishmania major cyclin 9, putative 0.0022 0.0156 0.0541
Brugia malayi Protein kinase domain containing protein 0.0015 0.006 0.0136
Loa Loa (eye worm) D-ets-2 protein 0.0012 0.0012 0.0024
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0013 0.0028 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0769 0.0769
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0016 0.0065 0.0324
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0401 0.0961
Echinococcus granulosus raf serine:threonine protein kinase 0.0013 0.0027 0.0026
Echinococcus granulosus single minded 2 0.0043 0.0436 0.0435
Schistosoma mansoni diacylglycerol kinase theta 0.0013 0.0027 0.0027
Onchocerca volvulus 0.0046 0.0473 0.1097
Schistosoma mansoni single-minded 0.0053 0.0572 0.0572
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.028 0.0279
Loa Loa (eye worm) hypothetical protein 0.0055 0.059 0.137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.012 0.0286
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0134 0.0535
Trypanosoma cruzi cyclin, putative 0.0194 0.2465 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0013 0.0028 0.0062
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.1619 0.8221
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0025 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0125 0.0288
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0098 0.0492
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0305 0.0305
Onchocerca volvulus 0.0039 0.0386 0.0896
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0153 0.0776
Giardia lamblia Hypothetical protein 0.0092 0.1096 0.2636
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0016 0.0065 0.0324
Loa Loa (eye worm) hypothetical protein 0.0095 0.1137 0.2643
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0043 0.0097
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0098 0.039
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0517 0.1241
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.0077 0.0076
Echinococcus granulosus cGMP dependent protein kinase 0.0012 0.0024 0.0023
Brugia malayi DKFZp564C0469 protein 0.0011 0.0002 0.0002
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0143
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0148 0.0343
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0002 0.0005
Echinococcus granulosus N chimaerin 0.0013 0.0027 0.0026
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0048 0.0047
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0401 0.04
Echinococcus multilocularis hyperpolarization activated cyclic 0.0013 0.0028 0.0026
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.0156 0.0361
Echinococcus multilocularis serine:threonine protein kinase 38 0.002 0.0125 0.0124
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0223 0.2854 0.6637
Schistosoma mansoni g1/s-specific cyclin C 0.0022 0.0156 0.0156
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.1443 0.7285
Trichomonas vaginalis cyclin D, putative 0.0092 0.1096 0.2636
Schistosoma mansoni hypothetical protein 0.0016 0.0068 0.0068
Toxoplasma gondii cytochrome p450 superfamily protein 0.0016 0.0065 0.0328
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0148 0.0747
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0025 0.0055
Echinococcus multilocularis protein kinase shaggy 0.0159 0.1988 0.1987
Trichomonas vaginalis cyclins, putative 0.0022 0.0156 0.0372
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0068 0.0067
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0159 0.1988 0.4623
Plasmodium falciparum cGMP-dependent protein kinase 0.0012 0.0024 0.0112
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0012 0.001
Echinococcus granulosus cyclins 0.0092 0.1096 0.1095
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0089 0.0204
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0002
Schistosoma mansoni cytochrome P450 0.0016 0.0065 0.0065
Brugia malayi hypothetical protein 0.0022 0.0156 0.0361
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.007 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0025 0.0055
Entamoeba histolytica protein kinase, putative 0.002 0.0125 0.0301
Brugia malayi RhoGAP domain containing protein 0.0013 0.0027 0.0061
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0401 0.1619
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0148 0.0595
Toxoplasma gondii cyclin 4, putative 0.0022 0.0156 0.0786
Mycobacterium tuberculosis Probable reductase 0.0118 0.1443 0.7285
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.039
Brugia malayi cytochrome P450 0.0016 0.0065 0.0149
Trichomonas vaginalis hypothetical protein 0.0012 0.0025 0.0055
Trypanosoma brucei rac serine-threonine kinase, putative 0.002 0.0125 0.05
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0517 0.0516
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0089 0.0088
Echinococcus multilocularis lamin dm0 0.003 0.0254 0.0252
Echinococcus multilocularis cyclin k 0.0022 0.0156 0.0155
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0016 0.0065 0.0324
Echinococcus multilocularis protein kinase c iota type 0.0033 0.0295 0.0294
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.012 0.0286
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0025 0.0125
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0012 0.001
Trichomonas vaginalis cyclin B, putative 0.0194 0.2465 0.5933
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0075 0.0298
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0025 0.0024
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.002 0.0125 0.0288
Brugia malayi hypothetical protein 0.0111 0.1348 0.3133
Schistosoma mansoni hypothetical protein 0.0012 0.0012 0.0012
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0159 0.1988 0.1987
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.4153 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0025 0.0055
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0517 0.2091
Mycobacterium ulcerans endonuclease IV 0.0084 0.0984 0.5025
Loa Loa (eye worm) hypothetical protein 0.0054 0.0584 0.1356
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0084 0.0984 0.4859
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.033 0.033
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0002 0.0002
Echinococcus multilocularis lamin 0.003 0.0254 0.0252
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0401 0.1543
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0013 0.0027 0.0061
Schistosoma mansoni lamin 0.003 0.0254 0.0254
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0043 0.0042
Onchocerca volvulus Cyclin L homolog 0.0022 0.0156 0.0361
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0134 0.0535
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.039
Giardia lamblia Cyclin fold protein 1, putative 0.0022 0.0156 0.0372
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0016 0.0065 0.0324
Brugia malayi Ets-domain containing protein 0.0079 0.0922 0.2142
Trichomonas vaginalis cyclins, putative 0.0124 0.1525 0.3668
Loa Loa (eye worm) ets-domain-containing protein 0.0012 0.0012 0.0024
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0013 0.0027 0.0026
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0012 0.0025 0.0055
Echinococcus granulosus ewsr:fli fusion protein type 0.0012 0.0012 0.001
Echinococcus multilocularis Chromo domain 0.0012 0.0025 0.0024
Schistosoma mansoni hypothetical protein 0.0037 0.0358 0.0358
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0025 0.0115
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0043 0.0042
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0013 0.0027 0.0027
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0214 0.2731 0.2731
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0134 0.0317
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0148 0.0747
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.0156 0.0361
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0022 0.0156 0.0786
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0001 0.0001
Echinococcus granulosus protein C ets 2 0.0012 0.0012 0.001
Echinococcus granulosus cyclin B3 1 0.0092 0.1096 0.1095
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.002 0.0125 0.0124
Trichomonas vaginalis cyclins, putative 0.0194 0.2465 0.5933
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0076 0.0179
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0098 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0025 0.0055
Brugia malayi Protein kinase c protein 2 0.01 0.1205 0.2801
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0024
Loa Loa (eye worm) hypothetical protein 0.0016 0.0077 0.0177
Echinococcus granulosus Diacylglycerol kinase theta 0.0013 0.0027 0.0026
Echinococcus granulosus G1:S specific cyclin D1 0.0022 0.0156 0.0155
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0098 0.0484
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0006 0.0015
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.0077 0.0076
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0134 0.0362
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0098 0.0492
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0098 0.0097
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0002 0.0009
Echinococcus multilocularis chromobox protein 2 0.0012 0.0025 0.0024
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0049 0.0111
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0012 0.0024 0.0122
Echinococcus granulosus protein kinase c eta type 0.0013 0.0027 0.0026
Trypanosoma brucei cdc2-related kinase 1 0.0049 0.0517 0.2091
Entamoeba histolytica protein kinase, putative 0.002 0.0125 0.0301
Loa Loa (eye worm) hypothetical protein 0.0331 0.4299 1
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0084 0.0984 0.2286
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.3333 0.3332
Entamoeba histolytica cyclin family protein 0.0092 0.1096 0.264
Leishmania major cytochrome p450-like protein 0.0016 0.0065 0.0168
Trichomonas vaginalis cyclin B, putative 0.0092 0.1096 0.2636
Trichomonas vaginalis AGC family protein kinase 0.002 0.0125 0.0296
Echinococcus granulosus cyclin B 0.0194 0.2465 0.2464
Trichomonas vaginalis cyclin B3, putative 0.0092 0.1096 0.2636
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0025 0.0125
Brugia malayi Protein kinase domain containing protein 0.002 0.0125 0.0288
Trypanosoma brucei cyclin 9 0.0022 0.0156 0.0627
Echinococcus granulosus protein kinase C gamma type 0.0105 0.127 0.1269
Brugia malayi M-phase phosphoprotein, mpp8 0.0111 0.1346 0.3128
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0043 0.0099
Brugia malayi Protein kinase domain containing protein 0.0018 0.0101 0.0232
Schistosoma mansoni ap endonuclease 0.0021 0.0134 0.0134
Onchocerca volvulus 0.0264 0.3395 0.7895
Echinococcus multilocularis cpg binding protein 0.0033 0.0303 0.0302
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0401 0.04
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0016 0.0065 0.0324
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0043 0.0099
Loa Loa (eye worm) cytochrome P450 0.0016 0.0065 0.0149
Brugia malayi Cyclin C 0.0022 0.0156 0.0361
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0043 0.0167
Echinococcus granulosus Cyclin L1 0.0022 0.0156 0.0155
Brugia malayi RhoGEF domain containing protein 0.0013 0.0027 0.0061
Loa Loa (eye worm) AGC/PKN protein kinase 0.002 0.0125 0.0288
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0134 0.0132
Echinococcus multilocularis Ankyrin 0.0016 0.007 0.0069
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0401 0.04
Toxoplasma gondii cyclin dependent kinase binding protein 0.0022 0.0156 0.0786
Trypanosoma cruzi cAMP binding protein, putative 0.0013 0.0027 0.0103
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0088 0.1035 0.2405
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0517 0.1245
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0386 0.1968
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0055
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0254 0.0587
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0043 0.0077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.039
Loa Loa (eye worm) hypothetical protein 0.0111 0.1348 0.3133
Trichomonas vaginalis cyclin A, putative 0.0022 0.0156 0.0372
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0517 0.12
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0016 0.0065 0.0324
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0061
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.1178 0.1178
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.0099
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0097
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0024 0.0023
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0552 0.0551
Echinococcus multilocularis Diacylglycerol kinase theta 0.0013 0.0027 0.0026
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0065 0.0064
Echinococcus granulosus lamin dm0 0.003 0.0254 0.0252
Trypanosoma cruzi cyclin 6, putative 0.0194 0.2465 1
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0098 0.1178 0.1177
Entamoeba histolytica cyclin, domain containing protein 0.0022 0.0156 0.0376
Trypanosoma brucei mitotic cyclin 6 0.0194 0.2465 1
Toxoplasma gondii hypothetical protein 0.007 0.0797 0.401
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0013 0.0028 0.0062
Loa Loa (eye worm) hypothetical protein 0.0068 0.0767 0.1782
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0025 0.0025
Loa Loa (eye worm) CYL-1 protein 0.0022 0.0156 0.0361
Echinococcus granulosus cyclin A3 4 0.0022 0.0156 0.0155
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0148 0.0343
Echinococcus granulosus RNA directed DNA polymerase 0.0083 0.0967 0.0966
Schistosoma mansoni chromobox protein 0.0012 0.0025 0.0025
Echinococcus multilocularis cyclin b3 0.0092 0.1096 0.1095
Echinococcus granulosus cyclin k 0.0022 0.0156 0.0155
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0626 0.1454
Echinococcus granulosus chromobox protein 1 0.0012 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0047 0.0485 0.1125
Echinococcus multilocularis GPCR, family 2 0.0017 0.0089 0.0088
Schistosoma mansoni hypothetical protein 0.0022 0.0156 0.0156
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0093
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0013 0.0028 0.0062
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0098 0.7298
Entamoeba histolytica diacylglycerol kinase, putative 0.0013 0.0027 0.0066
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0025 0.0125
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0098 0.0225
Onchocerca volvulus Cyclin L homolog 0.0022 0.0156 0.0361
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0517 0.1241
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0194 0.0449
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.002 0.0125 0.0288
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0156 0.0361
Brugia malayi hypothetical protein 0.0259 0.3333 0.7752
Echinococcus multilocularis cyclin t1 0.0022 0.0156 0.0155
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0013 0.0028 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.0099
Echinococcus multilocularis cyclin B 0.0194 0.2465 0.2464
Echinococcus multilocularis hyperpolarization activated cyclic 0.0013 0.0028 0.0026
Brugia malayi Ets-domain containing protein 0.0079 0.0922 0.2142
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1612 0.3748
Loa Loa (eye worm) hypothetical protein 0.0111 0.1346 0.3128
Brugia malayi Pax transcription factor protein 2 0.0264 0.3395 0.7895
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.4153 1
Brugia malayi transcription factor E74 isoform 0.0012 0.0012 0.0024
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0566 0.1314
Schistosoma mansoni hypothetical protein 0.0186 0.2348 0.2348
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0401 0.04
Loa Loa (eye worm) hypothetical protein 0.0017 0.0089 0.0204
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0134 0.0663
Trichomonas vaginalis cyclin B, putative 0.0194 0.2465 0.5933
Echinococcus granulosus ETS transcription factor Elf 1 0.0012 0.0012 0.001
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0028 0.0028
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0148 0.0147
Echinococcus multilocularis protein kinase c epsilon type 0.0035 0.033 0.0329
Echinococcus granulosus cyclin dependent kinase 5 0.0049 0.0517 0.0516
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.1956 1
Entamoeba histolytica hypothetical protein 0.0012 0.0025 0.006
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.1443 0.7374
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0075 0.0298
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0125 0.0125
Trypanosoma cruzi cyclin, putative 0.0194 0.2465 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0156 0.0361
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.1443 0.7285
Brugia malayi Cytochrome P450 family protein 0.0025 0.0194 0.0449
Trichomonas vaginalis cyclin D, putative 0.0092 0.1096 0.2636
Echinococcus granulosus bloom syndrome protein 0.0022 0.0148 0.0147
Trypanosoma brucei cdc2-related kinase 3 0.0049 0.0517 0.2091
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0148 0.0147
Schistosoma mansoni cpg binding protein 0.0033 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0017 0.0089 0.0089
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.1619 0.8221
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0254 0.0587
Schistosoma mansoni hypothetical protein 0.0012 0.0012 0.0012
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.007 0.0159
Onchocerca volvulus 0.0053 0.0566 0.1314
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0159 0.1988 0.8064
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0006 0.0006
Giardia lamblia Fructose-bisphosphate aldolase 0.032 0.4153 1
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0153 0.0354
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0089 0.0088
Schistosoma mansoni vav2 0.0013 0.0027 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0305 0.0305
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0068 0.0157
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0572 0.0572
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0098 0.0232
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.007 0.007
Schistosoma mansoni protein kinase C mu 0.0015 0.006 0.006
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0013 0.0028 0.0026
Plasmodium falciparum cyclin 0.0092 0.1096 0.551
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0027 0.0061
Schistosoma mansoni hypothetical protein 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0102 0.1226 0.2849
Schistosoma mansoni dishevelled 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.007 0.0161
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0016 0.0065 0.0324
Echinococcus granulosus chromobox protein 1 0.0012 0.0025 0.0024
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0098 0.0493
Schistosoma mansoni protein kinase C mu 0.0013 0.0027 0.0027
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0098 0.0979
Schistosoma mansoni ets 0.0012 0.0012 0.0012
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0194 0.0983
Schistosoma mansoni serine/threonine kinase 0.002 0.0125 0.0125
Schistosoma mansoni chromobox protein 0.0012 0.0025 0.0025
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0134 0.0322
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0156 0.0361
Brugia malayi hypothetical protein 0.0134 0.1658 0.3855
Echinococcus multilocularis ewsr:fli fusion protein type 0.0012 0.0012 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.2925 0.6804
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0002 0.0003
Echinococcus granulosus cyclin b3 0.0092 0.1096 0.1095
Brugia malayi diacylglycerol kinase 0.0013 0.0027 0.0061
Trichomonas vaginalis cyclins, putative 0.0194 0.2465 0.5933
Trichomonas vaginalis cyclin B3, putative 0.0022 0.0156 0.0372
Onchocerca volvulus 0.003 0.0254 0.0587
Echinococcus multilocularis serine:threonine protein kinase N2 0.002 0.0125 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.006 0.006
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.1956 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.002 0.0125 0.0288
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0002 0.0002
Loa Loa (eye worm) AGC/NDR protein kinase 0.002 0.0125 0.0288
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.1988 0.4784
Onchocerca volvulus Huntingtin homolog 0.0134 0.1658 0.3855
Plasmodium falciparum thioredoxin reductase 0.0052 0.0552 0.2771
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0156 0.0372
Brugia malayi Protein kinase domain containing protein 0.0049 0.0517 0.12
Brugia malayi Cyclin, N-terminal domain containing protein 0.0194 0.2465 0.5732
Schistosoma mansoni diacylglycerol kinase theta 0.0013 0.0027 0.0027
Giardia lamblia Kinase, CMGC GSK 0.0159 0.1988 0.4784
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0194 0.2465 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0305 0.0304
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0673 0.3386
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0013 0.0027 0.0061
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0153 0.0354
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0025 0.006
Brugia malayi Cytochrome P450 family protein 0.0016 0.0065 0.0149
Echinococcus granulosus protein kinase c epsilon type 0.0035 0.033 0.0329
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0055
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0517 0.1241
Echinococcus multilocularis chromobox protein 1 0.0012 0.0025 0.0024
Echinococcus multilocularis G1:S specific cyclin D1 0.0022 0.0156 0.0155
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0156 0.0361
Schistosoma mansoni dep domain containing protein 0.0011 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0186 0.2348 0.2348
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.0156 0.0361
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0279 0.0647
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0134 0.0535
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0153 0.0467
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.4153 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0049 0.0048
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0148 0.0343
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0134 0.0317
Echinococcus multilocularis protein kinase c eta type 0.0013 0.0027 0.0026
Brugia malayi Cytochrome P450 family protein 0.0025 0.0194 0.0449
Echinococcus multilocularis cyclins 0.0092 0.1096 0.1095
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0024 0.0023
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0517 0.1245
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0069 0.0162
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0098 0.0173
Chlamydia trachomatis endonuclease IV 0.0084 0.0984 1
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0517 0.2091
Schistosoma mansoni cyclin k 0.0022 0.0156 0.0156
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0159 0.1988 0.4623
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0386 0.0896
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0077 0.0077
Trypanosoma cruzi CYC2-like cyclin, putative 0.0194 0.2465 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.1619 0.8279
Schistosoma mansoni atypical protein kinase C 0.0033 0.0295 0.0295
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0013 0.0027 0.0027
Entamoeba histolytica protein kinase domain containing protein 0.0159 0.1988 0.4787
Brugia malayi CHD4 protein 0.0014 0.0049 0.0111
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0401 0.093
Trypanosoma cruzi cyclin 9, putative 0.0022 0.0156 0.0627
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.4153 1
Leishmania major cyclin 0.0194 0.2465 1
Schistosoma mansoni hypothetical protein 0.0053 0.0566 0.0566
Brugia malayi intermediate filament protein 0.003 0.0254 0.0587
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.0065 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1096 0.2636
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0061
Entamoeba histolytica cyclin, putative 0.0194 0.2465 0.5935
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0159 0.1988 0.1987
Loa Loa (eye worm) hypothetical protein 0.0022 0.0156 0.0361
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0065 0.0257
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.094 0.0939
Echinococcus granulosus NDR protein kinase 0.002 0.0125 0.0124
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0049 0.0517 0.26
Treponema pallidum fructose-bisphosphate aldolase 0.032 0.4153 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0305 0.0707
Brugia malayi protein kinase C II. 0.0035 0.033 0.0766
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0401 0.04
Trichomonas vaginalis cyclins, putative 0.0194 0.2465 0.5933
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0011
Echinococcus granulosus lamin 0.003 0.0254 0.0252
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0517 0.0516
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0084 0.0984 0.5025
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0025 0.0025
Schistosoma mansoni rac gtpase activating protein 0.0013 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0025 0.0055
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0016 0.0065 0.0257
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0002
Echinococcus granulosus geminin 0.0186 0.2348 0.2347
Toxoplasma gondii thioredoxin reductase 0.0052 0.0552 0.2778
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0002 0.0009
Loa Loa (eye worm) AGC/PKG protein kinase 0.0012 0.0024 0.0054
Brugia malayi topoisomerase 0.0011 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0011 0.0002 0.0005
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0013 0.0027 0.0026
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0401 0.0961
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0517 0.2091
Echinococcus granulosus protein kinase shaggy 0.0159 0.1988 0.1987
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0061
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0153 0.0776
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0517 0.1241
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.011
Trichomonas vaginalis cyclins, putative 0.0022 0.0156 0.0372
Trichomonas vaginalis set domain proteins, putative 0.026 0.3348 0.8061
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0016 0.0065 0.0324
Plasmodium falciparum glycogen synthase kinase 3 0.0159 0.1988 1
Plasmodium falciparum thioredoxin reductase 0.0018 0.0098 0.0484
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0016 0.0065 0.0324
Schistosoma mansoni DNA ligase IV 0.0011 0.0002 0.0002
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0427 0.1024
Schistosoma mansoni cyclin d 0.0022 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0002
Echinococcus granulosus unc 13 munc13 0.0015 0.0063 0.0062
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.002 0.0125 0.0124
Brugia malayi SET domain containing protein 0.0014 0.005 0.0114
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0462 0.0461
Brugia malayi intracellular kinase 0.0159 0.1988 0.4623
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0148 0.0595
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0012 0.0012 0.0024
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0194 0.078
Loa Loa (eye worm) raf kinase 0.0013 0.0027 0.0061
Loa Loa (eye worm) hypothetical protein 0.0179 0.2256 0.5246
Brugia malayi hypothetical protein 0.0011 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0055
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0049 0.0517 0.2019
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0148 0.0147
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0011
Schistosoma mansoni ap endonuclease 0.0021 0.0134 0.0134
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0305 0.1535
Entamoeba histolytica protein kinase, putative 0.002 0.0125 0.0301
Giardia lamblia Cyclin B-like protein 0.0022 0.0156 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0025 0.0055
Mycobacterium leprae Conserved hypothetical protein 0.0016 0.0065 0.0324
Brugia malayi PAS domain containing protein 0.0053 0.0572 0.1329
Echinococcus multilocularis cyclin G2 0.0022 0.0156 0.0155
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0025 0.0055
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0025 0.0125
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0134 0.0308
Echinococcus multilocularis myotubularin protein 13 0.0013 0.0027 0.0026
Brugia malayi Ets-domain containing protein 0.0012 0.0012 0.0024
Schistosoma mansoni hypothetical protein 0.0017 0.0089 0.0089
Echinococcus multilocularis microtubule associated protein 2 0.0756 1 1
Echinococcus granulosus Chromobox protein 3 0.0012 0.0025 0.0024
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0098 0.0493
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0065 0.0257
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0401 0.0961
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0089 0.0088
Schistosoma mansoni ets-related 0.0241 0.3089 0.3089
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0025 0.0055
Brugia malayi glutathione reductase 0.0052 0.0552 0.1282
Brugia malayi hypothetical protein 0.0011 0.0002 0.0002
Brugia malayi hypothetical protein 0.0022 0.0156 0.0361
Leishmania major mitotic cyclin, putative 0.0022 0.0156 0.0541
Mycobacterium ulcerans hypothetical protein 0.0022 0.0153 0.0776
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0552 0.2234
Trypanosoma brucei trypanothione reductase 0.0052 0.0552 0.2234
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0055
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0016 0.0065 0.0324
Trichomonas vaginalis cyclin B, putative 0.0194 0.2465 0.5933
Brugia malayi hypothetical protein 0.0179 0.2256 0.5246
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1612 0.3748
Schistosoma mansoni Cyclin fold protein 0.0022 0.0156 0.0156
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.012 0.0286
Brugia malayi DNA-binding protein D-ETS-3 0.0012 0.0012 0.0024
Loa Loa (eye worm) intermediate filament protein 0.003 0.0254 0.0587
Echinococcus multilocularis cyclin 0.0022 0.0156 0.0155
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0089 0.0204
Onchocerca volvulus Protein CNPPD1 homolog 0.0022 0.0156 0.0361
Echinococcus granulosus chromobox protein 2 0.0012 0.0025 0.0024
Brugia malayi Protein cec-1. 0.0012 0.0025 0.0055
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.059 0.137
Trichomonas vaginalis cyclin B3, putative 0.0022 0.0156 0.0372
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0015 0.0063 0.0062
Onchocerca volvulus 0.0111 0.1346 0.3128
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.4153 1
Plasmodium vivax cyclin homologue, putative 0.0022 0.0156 0.0786
Giardia lamblia Cyclin A 0.0092 0.1096 0.2636
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0049 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.4153 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0006 0.0015
Loa Loa (eye worm) heterochromatin protein 1 0.0012 0.0025 0.0055
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.002 0.0125 0.0124
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0025 0.006
Echinococcus granulosus cyclin dependent kinase 1 0.0049 0.0517 0.0516
Schistosoma mansoni lamin 0.003 0.0254 0.0254
Brugia malayi Cyclin, N-terminal domain containing protein 0.0194 0.2465 0.5732
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0016 0.0065 0.0324
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0024 0.0023
Schistosoma mansoni survival motor neuron protein 0.0053 0.0566 0.0566
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.1988 0.4784
Entamoeba histolytica cyclin, domain containing protein 0.0022 0.0156 0.0376
Entamoeba histolytica cyclin C, putative 0.0022 0.0156 0.0376
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0022 0.0156 0.0361
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0061
Loa Loa (eye worm) hypothetical protein 0.0194 0.2465 0.5732
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0098 0.0097
Leishmania major cytochrome p450-like protein 0.0016 0.0065 0.0168
Trypanosoma brucei cyclin 3 0.0022 0.0156 0.0627
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0098 0.0493
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0043 0.0099
Echinococcus multilocularis cyclin y 0.0022 0.0156 0.0155
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0984 0.4944
Echinococcus granulosus cyclins 0.0092 0.1096 0.1095
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0025 0.0115
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0043 0.0042
Brugia malayi Fli-1 protein 0.0241 0.3089 0.7184
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0098 0.039
Loa Loa (eye worm) hypothetical protein 0.0022 0.0156 0.0361
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0016 0.0065 0.0324
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0098 0.039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0194 0.2465 0.5732
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0002 0.0001
Schistosoma mansoni topbp1 0.0011 0.0002 0.0002
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0517 0.1241
Echinococcus multilocularis cyclins 0.0092 0.1096 0.1095
Trichomonas vaginalis AGC family protein kinase 0.002 0.0125 0.0296
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.059 0.137
Echinococcus multilocularis ETS transcription factor Elf 5 0.0012 0.0012 0.001
Onchocerca volvulus 0.026 0.335 0.7791
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0517 0.12
Plasmodium vivax glycogen synthase kinase 3, putative 0.0159 0.1988 1
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0025 0.0055
Onchocerca volvulus 0.0013 0.0027 0.0061
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0386 0.0385
Brugia malayi Pre-SET motif family protein 0.0033 0.0305 0.0707
Loa Loa (eye worm) hypothetical protein 0.0029 0.0246 0.057
Echinococcus multilocularis cyclins 0.0092 0.1096 0.1095
Brugia malayi Cytochrome P450 family protein 0.0057 0.0626 0.1454
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.059 0.137
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0098 0.0232
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.002 0.0125 0.0288
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0025 0.0125
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0077 0.0077
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0512 0.0512
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0148 0.0738
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0024 0.0024
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0025 0.0055
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0015 0.006 0.0136
Schistosoma mansoni hypothetical protein 0.0013 0.0027 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0156 0.0786
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0401 0.04
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0125 0.0125
Mycobacterium ulcerans epimerase 0.0022 0.0153 0.0776
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.1178 0.1178
Echinococcus multilocularis 0.0016 0.0065 0.0064
Echinococcus multilocularis chromobox protein 1 0.0012 0.0025 0.0024
Plasmodium vivax protein kinase Crk2 0.0049 0.0517 0.26
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.002 0.0125 0.0124
Trichomonas vaginalis cyclins, putative 0.0194 0.2465 0.5933
Echinococcus multilocularis raf serine:threonine protein kinase 0.0013 0.0027 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.012 0.0286
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0024 0.0024
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0028 0.0028
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0022 0.0156 0.0786
Echinococcus multilocularis nibrin 0.0011 0.0002 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.039
Plasmodium vivax glutathione reductase, putative 0.0052 0.0552 0.2778
Schistosoma mansoni DNA helicase recq5 0.0022 0.0148 0.0148
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0552 0.1282
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0068 0.0157
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0156 0.0627
Echinococcus multilocularis serine threonine protein kinase 0.0105 0.127 0.1269
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0156 0.0361
Loa Loa (eye worm) fli-1 protein 0.0241 0.3089 0.7184
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0025 0.0055
Loa Loa (eye worm) hypothetical protein 0.0259 0.3333 0.7752
Echinococcus multilocularis cyclins 0.0092 0.1096 0.1095
Onchocerca volvulus 0.0331 0.4299 1
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0015 0.006 0.0136
Trichomonas vaginalis cyclin B, putative 0.0022 0.0156 0.0372
Echinococcus multilocularis cyclin y 0.0022 0.0156 0.0155
Plasmodium falciparum cyclin 1 0.0022 0.0156 0.0777
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0214 0.2731 0.2731
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0002 0.0009
Loa Loa (eye worm) helicase 0.0012 0.0025 0.0055
Onchocerca volvulus Huntingtin homolog 0.0134 0.1658 0.3855
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0013 0.0027 0.0061
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.4153 1
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0148 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0025 0.0055
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0002 0.0002
Echinococcus granulosus cyclin t1 0.0022 0.0156 0.0155
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.1443 0.7285
Echinococcus multilocularis cyclins 0.0092 0.1096 0.1095
Entamoeba histolytica cyclin, putative 0.0092 0.1096 0.264
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0922 0.0921
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0134 0.0132
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0098 0.0302
Schistosoma mansoni cyclin B 0.0194 0.2465 0.2465
Loa Loa (eye worm) RecQ helicase 0.0022 0.0148 0.0343
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0134 0.0448
Echinococcus multilocularis protein C ets 2 0.0012 0.0012 0.001
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0922 0.0921
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.012 0.0286
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.012 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0156 0.0372
Loa Loa (eye worm) hypothetical protein 0.0037 0.0358 0.083
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0084 0.0984 0.2286
Brugia malayi Cyclin, N-terminal domain containing protein 0.0214 0.2731 0.6352
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0552 0.2778
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.0302
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0025 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0025 0.0055
Schistosoma mansoni DNA helicase recq1 0.0022 0.0148 0.0148
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0049 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.4153 1
Echinococcus multilocularis cyclin dependent kinase 0.0049 0.0517 0.0516
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0401 0.1619
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0062
Echinococcus multilocularis Cyclin L1 0.0022 0.0156 0.0155
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0022 0.0156 0.0155
Echinococcus multilocularis RNA directed DNA polymerase 0.0083 0.0967 0.0966
Toxoplasma gondii hypothetical protein 0.0011 0.0001 0.0006
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0025 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.144 0.144
Brugia malayi protein kinase C3,putative 0.0015 0.006 0.0136
Plasmodium vivax cyclin 4, putative 0.0022 0.0156 0.0786
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0148 0.0353
Schistosoma mansoni dishevelled 0.0011 0.0001 0.0001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0462 0.0461
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0462 0.1073
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0013 0.0028 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0401 0.0961
Schistosoma mansoni microtubule-associated protein tau 0.0756 1 1
Echinococcus granulosus cyclin y 0.0022 0.0156 0.0155
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0025 0.0115
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0134 0.0308
Schistosoma mansoni cyclins 0.0092 0.1096 0.1096
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0055
Brugia malayi C1-like domain containing protein 0.0015 0.006 0.0136
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0025 0.0055
Trichomonas vaginalis AGC family protein kinase 0.002 0.0125 0.0296
Loa Loa (eye worm) glutathione reductase 0.0052 0.0552 0.1282
Echinococcus granulosus myotubularin protein 13 0.0013 0.0027 0.0026
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0043 0.0167
Trichomonas vaginalis AGC family protein kinase 0.002 0.0125 0.0296
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0015 0.006 0.0058
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0068 0.0068
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0016 0.0065 0.0324
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0156 0.0777
Leishmania major protein kinase, putative 0.0026 0.021 0.0761
Brugia malayi Death domain containing protein 0.0016 0.0068 0.0157
Echinococcus multilocularis unc 13 (munc13) 0.0015 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0061
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0098 0.0492
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.0099
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.1443 0.7285
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0156 0.0372
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.012 0.0286
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0001 0.0001
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0068 0.0067
Brugia malayi Ras association domain family 1 isoform A 0.0013 0.0027 0.0061
Schistosoma mansoni cyclin G 0.0022 0.0156 0.0156
Trichomonas vaginalis AGC family protein kinase 0.002 0.0125 0.0296
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0089 0.0088
Echinococcus granulosus cyclins 0.0022 0.0156 0.0155
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0055
Onchocerca volvulus 0.0022 0.0156 0.0361
Trichomonas vaginalis cyclin B, putative 0.0022 0.0156 0.0372
Brugia malayi Pre-SET motif family protein 0.0229 0.2925 0.6804
Plasmodium falciparum glutathione reductase 0.0018 0.0098 0.0484
Echinococcus granulosus cyclin y 0.0022 0.0156 0.0155
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0035 0.033 0.0766
Toxoplasma gondii hypothetical protein 0.0022 0.0156 0.0786
Schistosoma mansoni unc-13 (munc13) 0.0015 0.0063 0.0063
Brugia malayi Hr1 repeat family protein 0.002 0.0125 0.0288
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0401 0.0401
Brugia malayi cyclin fold protein 1 variant b 0.0022 0.0156 0.0361
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0401 0.0401
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0004 0.0006
Schistosoma mansoni chromobox protein 0.0012 0.0025 0.0025
Echinococcus granulosus cyclin 0.0022 0.0156 0.0155
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0984 0.4948
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0025 0.0055
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0156 0.0361
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0025 0.0024
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0006 0.0028
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0043 0.0042
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0584 0.0584
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0028 0.0028
Trypanosoma cruzi mitotic cyclin, putative 0.0022 0.0156 0.0627
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0016 0.0065 0.0324
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0098 0.0302
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0034 0.0077
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0043 0.0099
Leishmania major hypothetical protein, conserved 0.0013 0.0027 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0473 0.0473
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0012 0.0012 0.0024
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0001 0.0001
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0148 0.0509
Trichomonas vaginalis AGC family protein kinase 0.002 0.0125 0.0296
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0049 0.0517 0.2019
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0043 0.0099
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0061
Echinococcus granulosus cyclins 0.0092 0.1096 0.1095
Leishmania major protein kinase, putative 0.0016 0.0075 0.0209
Loa Loa (eye worm) pax transcription factor protein 2 0.0264 0.3395 0.7895
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0098 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0025 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0027 0.0027
Toxoplasma gondii AGC kinase 0.002 0.0125 0.0628
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0075 0.0298
Schistosoma mansoni unc-13 (munc13) 0.0015 0.0063 0.0063
Echinococcus multilocularis ETS transcription factor Elf 1 0.0012 0.0012 0.001
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0016 0.0065 0.0324
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0024
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0194 0.0449
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0022 0.0156 0.0777
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0022 0.0156 0.0786
Brugia malayi Heterochromatin protein 1 0.0012 0.0025 0.0055
Trichomonas vaginalis AGC family protein kinase 0.002 0.0125 0.0296
Echinococcus granulosus cyclin G2 0.0022 0.0156 0.0155
Echinococcus granulosus hyperpolarization activated cyclic 0.0013 0.0028 0.0026
Onchocerca volvulus 0.003 0.0254 0.0587
Echinococcus granulosus cyclins 0.0092 0.1096 0.1095
Echinococcus granulosus Rac GTPase activating protein 1 0.0013 0.0027 0.0026
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0022 0.0156 0.0627
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0004 0.0003
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.0028 0.0062
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0148 0.0353
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.4153 1
Entamoeba histolytica hypothetical protein 0.0012 0.0025 0.006
Echinococcus granulosus death domain containing protein 0.0016 0.0068 0.0067
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.002 0.0125 0.0124
Brugia malayi Pleckstrin Homology Domain 0.0013 0.0027 0.0061
Loa Loa (eye worm) hypothetical protein 0.0223 0.2854 0.6637
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0022 0.0156 0.0155
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0098 0.0484
Onchocerca volvulus 0.0015 0.0063 0.0143
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0034 0.0077
Brugia malayi chromobox protein homolog 3 0.0012 0.0025 0.0055
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0159 0.1988 0.1988
Onchocerca volvulus 0.0159 0.1988 0.4623
Loa Loa (eye worm) hypothetical protein 0.0035 0.0328 0.076
Toxoplasma gondii endonuclease IV APN 0.0084 0.0984 0.4948
Trichomonas vaginalis AGC family protein kinase 0.002 0.0125 0.0296
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0098 0.7298
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0068 0.0067
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0012 0.001
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0049 0.0517 0.12
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0148 0.0147
Echinococcus granulosus protein kinase c iota type 0.0033 0.0295 0.0294
Echinococcus multilocularis cyclins 0.0092 0.1096 0.1095
Brugia malayi hypoxia-induced factor 1 0.0165 0.207 0.4814
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.0028 0.0062
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.0156 0.0361
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0061
Toxoplasma gondii exonuclease III APE 0.0021 0.0134 0.0672
Loa Loa (eye worm) RasGEF domain-containing protein 0.0015 0.0062 0.0141
Entamoeba histolytica protein kinase, putative 0.002 0.0125 0.0301
Brugia malayi Uncoordinated protein 44 0.0016 0.0068 0.0157
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0194 0.078
Entamoeba histolytica hypothetical protein 0.0012 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0061
Trichomonas vaginalis cyclin D, putative 0.0022 0.0156 0.0372
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0043 0.0099
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.0302
Plasmodium vivax SET domain protein, putative 0.0033 0.0305 0.1535
Leishmania major cytochrome p450-like protein 0.0025 0.0194 0.0696
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0125 0.0125
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.3333 0.3332
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.0587
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0098 0.039
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0134 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0076 0.0179
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0025 0.0055
Schistosoma mansoni hypothetical protein 0.0022 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0093
Echinococcus multilocularis expressed conserved protein 0.0012 0.0024 0.0023
Onchocerca volvulus 0.0111 0.1346 0.3128
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0006 0.0028
Schistosoma mansoni elf1 0.0012 0.0012 0.0012
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0098 0.0232
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.094 0.0939
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0134 0.0674
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0006 0.0014
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0552 0.2576
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0028 0.0028
Giardia lamblia G2/mitotic-specific cyclin B 0.0194 0.2465 0.5933
Plasmodium falciparum glutathione reductase 0.0052 0.0552 0.2771
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0098 0.039
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0016 0.0065 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0025 0.0055
Onchocerca volvulus 0.0014 0.0043 0.0097
Brugia malayi RhoGAP domain containing protein 0.0013 0.0027 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0002
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0012 0.001
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0148 0.0358
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0401 0.0965
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0028 0.0028
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0022 0.0156 0.0156
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0083 0.0967 0.0966
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0015 0.006 0.0058
Trichomonas vaginalis AGC family protein kinase 0.002 0.0125 0.0296
Schistosoma mansoni hypothetical protein 0.0017 0.0089 0.0089
Brugia malayi CXXC zinc finger family protein 0.0031 0.0279 0.0647
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0015 0.006 0.0136
Entamoeba histolytica protein kinase, putative 0.0159 0.1988 0.4787
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0028 0.0028
Echinococcus multilocularis dnaJ subfamily B 0.0448 0.5869 0.5869
Schistosoma mansoni chromobox protein 0.0012 0.0025 0.0025
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0068 0.0157
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0061
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0159 0.1988 1
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0024 0.0024
Treponema pallidum NADH oxidase 0.0018 0.0098 0.0232
Echinococcus granulosus cyclin dependent kinase 0.0049 0.0517 0.0516
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0134 0.0672
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.1443 0.7285
Echinococcus multilocularis ets variant gene 4 0.0012 0.0012 0.001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0012 0.0025 0.0055
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.0077 0.0177
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0118 0.144 0.1439
Mycobacterium leprae putative cytochrome p450 0.0016 0.0065 0.0324
Schistosoma mansoni netrin receptor unc5 0.0016 0.0068 0.0068
Trypanosoma cruzi mitotic cyclin, putative 0.0022 0.0156 0.0627
Onchocerca volvulus 0.0011 0.0002 0.0002
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0025 0.0055
Loa Loa (eye worm) cyclin C 0.0022 0.0156 0.0361
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0517 0.2091
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0013 0.0026 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.012 0.0286
Schistosoma mansoni cyclin B3 0.0214 0.2731 0.2731
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.1619 0.8221
Echinococcus granulosus dnaJ subfamily B 0.0448 0.5869 0.5869
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.006 0.006
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0022 0.0156 0.0155
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0004 0.0003
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0427 0.1024
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0016 0.0065 0.0324

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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