Detailed information for compound 1342759

Basic information

Technical information
  • TDR Targets ID: 1342759
  • Name: 5-butan-2-ylidene-2-[4-[3-(trifluoromethyl)ph enyl]piperazin-1-yl]-1,3-thiazol-4-one
  • MW: 383.431 | Formula: C18H20F3N3OS
  • H donors: 0 H acceptors: 1 LogP: 4.73 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC/C(=C/1\SC(=NC1=O)N1CCN(CC1)c1cccc(c1)C(F)(F)F)/C
  • InChi: 1S/C18H20F3N3OS/c1-3-12(2)15-16(25)22-17(26-15)24-9-7-23(8-10-24)14-6-4-5-13(11-14)18(19,20)21/h4-6,11H,3,7-10H2,1-2H3/b15-12-
  • InChiKey: ZLNHEOKZRDDNPX-QINSGFPZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5Z)-5-butan-2-ylidene-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-4-one
  • 5-(1-methylpropylidene)-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]thiazol-4-one
  • (5Z)-5-(1-methylpropylidene)-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]thiazol-4-one
  • 5-(1-methylpropylidene)-2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-4-thiazolone
  • (5Z)-5-(1-methylpropylidene)-2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-4-thiazolone
  • SMR000148723
  • ZINC05478385
  • 5-[1-Methyl-prop-(Z)-ylidene]-2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-thiazol-4-one
  • MLS000558007

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0107 0.161 0.2971
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0088 0.0115
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0095 0.0175
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0323 0.1452
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0323 0.4758
Echinococcus granulosus calpain 5 0.004 0.0379 0.0379
Giardia lamblia High cysteine protein 0.0052 0.059 0.3888
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0211 0.0211
Echinococcus multilocularis transmembrane protease serine 3 0.0025 0.0095 0.0095
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0212 0.11
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0055 0.0643 0.4262
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Brugia malayi beta-lactamase family protein 0.0036 0.0307 0.0563
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0323 0.0655
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2804 0.6252
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0306 0.0306
Brugia malayi Cathepsin L-like precursor 0.0053 0.0613 0.119
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.1668 1
Toxoplasma gondii EGF family domain-containing protein 0.0052 0.059 0.2644
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0323 0.06
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0055 0.0643 0.0643
Onchocerca volvulus 0.0058 0.071 0.1625
Echinococcus granulosus importin subunit beta 1 0.0029 0.0176 0.0176
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0104 0.1557 0.2874
Echinococcus multilocularis neuropeptide receptor A26 0.0561 1 1
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.0379 0.212
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0454 0.0805
Schistosoma mansoni hypothetical protein 0.0025 0.0095 0.0175
Brugia malayi Calcium binding EGF domain containing protein 0.0052 0.059 0.1142
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0212 0.11
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1668 0.3052
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.4466 1
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2804 0.6252
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0176 0.0875
Onchocerca volvulus 0.0048 0.0526 0.1139
Echinococcus granulosus 6 phosphofructokinase 0.011 0.1668 0.1668
Trypanosoma brucei kinesin, putative 0.0028 0.0155 0.075
Echinococcus multilocularis calpain 0.004 0.0379 0.0379
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0183 0.034
Schistosoma mansoni septate junction protein 0.0052 0.059 0.1088
Echinococcus multilocularis calpain family protein 1, d 0.0079 0.1089 0.1089
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0055 0.0643 0.3734
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0613 0.3552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0212 0.0371
Echinococcus multilocularis GPCR, family 2 0.0031 0.0211 0.0211
Echinococcus multilocularis caspase 2 0.0034 0.0261 0.0261
Plasmodium vivax vivapain-3 0.0031 0.0212 0.2945
Onchocerca volvulus 0.0053 0.0613 0.1369
Echinococcus granulosus notch 0.0052 0.059 0.059
Leishmania major hypothetical protein, conserved 0.0036 0.0307 0.1681
Brugia malayi Cathepsin L-like precursor 0.0038 0.034 0.063
Echinococcus granulosus enteropeptidase 0.0025 0.0095 0.0095
Schistosoma mansoni ran 0.0022 0.0033 0.006
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0095 0.0175
Echinococcus multilocularis fk506 binding protein 0.0055 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.0053 0.0613 0.1099
Echinococcus multilocularis enteropeptidase 0.0025 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0095 0.0175
Echinococcus multilocularis lamin 0.0033 0.0236 0.0236
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0212 0.0392
Loa Loa (eye worm) hypothetical protein 0.0029 0.0176 0.0289
Echinococcus granulosus cathepsin b 0.0284 0.4874 0.4874
Onchocerca volvulus Cell death protein 3 homolog 0.0034 0.0261 0.044
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0052 0.059 0.1306
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0055 0.0643 0.1187
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0033 0.0236 0.04
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0055 0.0643 0.1377
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0183 0.034
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0055 0.0643 0.1154
Brugia malayi calpain 7 0.004 0.0379 0.0711
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0183 0.2467
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1668 1
Schistosoma mansoni hypothetical protein 0.0052 0.059 0.1088
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0236 0.04
Trypanosoma cruzi calpain cysteine peptidase, putative 0.004 0.0379 0.0716
Brugia malayi EGF-like domain containing protein 0.0052 0.059 0.1142
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0323 0.1777
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.004 0.0379 0.212
Brugia malayi Cathepsin L-like cysteine proteinase 0.0038 0.034 0.063
Schistosoma mansoni slit 0.0052 0.059 0.1088
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Brugia malayi EGF-like domain containing protein 0.0052 0.059 0.1142
Echinococcus granulosus neural cadherin 0.0052 0.059 0.059
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Brugia malayi Trypsin family protein 0.0025 0.0095 0.0127
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0323 0.0043
Schistosoma mansoni ap endonuclease 0.0037 0.0323 0.0596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0613 0.3552
Schistosoma mansoni hypothetical protein 0.0052 0.059 0.1088
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0526 0.0971
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0212 0.0371
Onchocerca volvulus 0.0052 0.059 0.1306
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Leishmania major cathepsin L-like protease 0.0053 0.0613 0.3552
Onchocerca volvulus 0.0053 0.0613 0.1369
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0088 0.0913
Echinococcus granulosus protein jagged 2 0.0052 0.059 0.059
Brugia malayi Cathepsin L-like precursor 0.0053 0.0613 0.119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0613 0.131
Entamoeba histolytica calpain large subunit domain III containing protein 0.0028 0.0155 0.075
Brugia malayi PHD-finger family protein 0.0025 0.01 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0488 0.0901
Brugia malayi EGF-like domain containing protein 0.0052 0.059 0.1142
Brugia malayi Cathepsin L-like precursor 0.0053 0.0613 0.119
Echinococcus granulosus calpain 0.004 0.0379 0.0379
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0183 0.034
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0025 0.0095 0.0095
Brugia malayi calpain family protein 1 0.0107 0.161 0.3233
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0236 0.04
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0095 0.0175
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2804 0.6252
Plasmodium vivax importin-beta 2, putative 0.0029 0.0176 0.2343
Loa Loa (eye worm) fibroinase 0.0053 0.0613 0.1099
Onchocerca volvulus 0.0052 0.059 0.1306
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0526 0.0938
Toxoplasma gondii cathepsin CPL 0.0053 0.0613 0.2757
Brugia malayi cathepsin L-like precursor 0.0038 0.034 0.063
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0307 0.0563
Schistosoma mansoni hypothetical protein 0.0031 0.0211 0.039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0454 0.0839
Onchocerca volvulus Slit protein homolog 0.0052 0.059 0.1306
Echinococcus granulosus neurogenic locus notch protein 0.0052 0.059 0.059
Plasmodium vivax calpain, putative 0.004 0.0379 0.5678
Schistosoma mansoni hypothetical protein 0.0058 0.071 0.1311
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0183 0.5
Echinococcus granulosus lamin 0.0033 0.0236 0.0236
Schistosoma mansoni notch 0.0052 0.059 0.1088
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0307 0.1353
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0533
Echinococcus granulosus GPCR family 2 0.0031 0.0211 0.0211
Trypanosoma brucei antigen, putative 0.004 0.0379 0.212
Onchocerca volvulus 0.023 0.3884 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0212 0.0371
Loa Loa (eye worm) hypothetical protein 0.0025 0.0095 0.0139
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0095 0.0175
Echinococcus multilocularis neural cadherin 0.0052 0.059 0.059
Echinococcus multilocularis Mastin 0.0025 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0307 0.062
Brugia malayi RNA, U transporter 1 0.0083 0.1175 0.2341
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Onchocerca volvulus 0.0052 0.059 0.1306
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0488 0.0488
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Schistosoma mansoni caspase-7 (C14 family) 0.0034 0.0261 0.0482
Schistosoma mansoni notch 0.0052 0.059 0.1088
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0136 0.2139 0.3925
Brugia malayi Trypsin family protein 0.0025 0.0095 0.0127
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0211 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0613 0.3552
Loa Loa (eye worm) cathepsin B 0.0099 0.1465 0.2677
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0613 0.119
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0379 0.0716
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.1668 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.4912 0.4912
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0104 0.1557 0.3125
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0212 0.11
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0073 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2804 0.6252
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Echinococcus multilocularis neurogenic locus protein delta 0.0052 0.059 0.059
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0284 0.4874 1
Echinococcus granulosus neurogenic locus protein delta 0.0052 0.059 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0379 0.0716
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0095 0.0175
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0593
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.0248
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0095 0.0175
Giardia lamblia Cathepsin B precursor 0.0099 0.1465 1
Giardia lamblia Cathepsin B precursor 0.0099 0.1465 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0379 0.0716
Brugia malayi EGF-like domain containing protein 0.0052 0.059 0.1142
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0643 0.3734
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0751 0.0751
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0307 0.0307
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.065 0.065
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0307 0.1681
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.065 0.065
Toxoplasma gondii exonuclease III APE 0.0037 0.0323 0.1379
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0047 0.0504 0.0897
Brugia malayi Cadherin domain containing protein 0.0052 0.059 0.1142
Loa Loa (eye worm) MBCTL1 0.0055 0.065 0.1167
Brugia malayi Cathepsin L-like precursor 0.0053 0.0613 0.119
Schistosoma mansoni calpain-7 (C02 family) 0.004 0.0379 0.07
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0613 0.131
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.4466 1
Schistosoma mansoni laminin gamma-3 chain 0.0052 0.059 0.1088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0323 0.0323
Loa Loa (eye worm) trypsin family protein 0.0025 0.0095 0.0139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0212 0.11
Toxoplasma gondii cathepsin B 0.0099 0.1465 0.6802
Mycobacterium ulcerans beta-lactamase 0.0036 0.0307 0.1353
Loa Loa (eye worm) calpain 5 0.0028 0.0155 0.0251
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0212 0.0369
Brugia malayi Bromodomain containing protein 0.0076 0.1037 0.2059
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0176 0.0176
Brugia malayi Trypsin family protein 0.0025 0.0095 0.0127
Brugia malayi cathepsin B-like cysteine proteinase 0.0284 0.4874 0.9923
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Onchocerca volvulus 0.0053 0.0613 0.1369
Loa Loa (eye worm) hypothetical protein 0.0095 0.1386 0.253
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0095 0.0175
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0526 0.0526
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0323 0.0595
Plasmodium vivax SET domain protein, putative 0.0029 0.0169 0.224
Schistosoma mansoni hypothetical protein 0.0068 0.0882 0.1627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0613 0.3552
Leishmania major cathepsin L-like protease 0.0053 0.0613 0.3552
Brugia malayi Pre-SET motif family protein 0.0029 0.0169 0.028
Schistosoma mansoni intermediate filament proteins 0.0033 0.0236 0.0435
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.0127
Schistosoma mansoni immunophilin 0.0055 0.0643 0.1187
Brugia malayi calpain 5 0.0028 0.0155 0.0251
Schistosoma mansoni calpain-7 (C02 family) 0.004 0.0379 0.07
Echinococcus granulosus neuropeptide receptor A26 0.0561 1 1
Entamoeba histolytica cysteine protease, putative 0.0053 0.0613 0.3552
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Echinococcus multilocularis neuropeptide s receptor 0.0561 1 1
Echinococcus multilocularis slit 2 protein 0.0052 0.059 0.059
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0211 0.0211
Loa Loa (eye worm) Notch2 0.0052 0.059 0.1055
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0284 0.4874 0.899
Trichomonas vaginalis set domain proteins, putative 0.023 0.3884 0.8687
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.034 0.188
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0212 0.0392
Brugia malayi 6-phosphofructokinase 0.011 0.1668 0.3351
Loa Loa (eye worm) calpain 0.004 0.0379 0.0666
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0307 0.0567
Brugia malayi EGF-like domain containing protein 0.0052 0.059 0.1142
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0095 0.0175
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0613 0.0613
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0099 0.1465 0.2959
Loa Loa (eye worm) hypothetical protein 0.0025 0.0095 0.0139
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1459 0.2924
Loa Loa (eye worm) cysteine protease 0.0053 0.0613 0.1099
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0088 0.0341
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0454 0.0839
Trypanosoma cruzi kinesin, putative 0.0028 0.0155 0.0253
Echinococcus granulosus cathepsin L cysteine proteinase 0.0053 0.0613 0.0613
Echinococcus granulosus cathepsin l1 0.0053 0.0613 0.0613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0613 0.3552
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0212 0.0371
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0055 0.0643 1
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1668 0.3688
Loa Loa (eye worm) phosphofructokinase 0.011 0.1668 0.3052
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0136 0.2139 0.3947
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0136 0.2139 0.4317
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.1668 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0088 0.0913
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2804 0.6252
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0212 0.11
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0095 0.0175
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2975 0.6637
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0055 0.0643 0.3734
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0613 0.0613
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0025 0.0095 0.0095
Onchocerca volvulus 0.0053 0.0613 0.1369
Echinococcus multilocularis lamin dm0 0.0033 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Trypanosoma cruzi cruzipain precursor, putative 0.0053 0.0613 0.12
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0053 0.0613 0.1099
Echinococcus granulosus caspase 2 0.0034 0.0261 0.0261
Brugia malayi notch-like transmembrane receptor 0.0052 0.059 0.1142
Onchocerca volvulus Arrow homolog 0.0136 0.2139 0.5395
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0307 0.0533
Onchocerca volvulus 0.0052 0.059 0.1306
Brugia malayi Cathepsin L-like precursor 0.0038 0.034 0.063
Echinococcus granulosus intermediate filament protein 0.0033 0.0236 0.0236
Onchocerca volvulus 0.0104 0.1557 0.386
Brugia malayi mbt repeat family protein 0.0048 0.0526 0.1012
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0056 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0488 0.0901
Schistosoma mansoni lamin 0.0033 0.0236 0.0435
Loa Loa (eye worm) hypothetical protein 0.0068 0.0882 0.1596
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0183 0.034
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.4466 0.9087
Echinococcus granulosus lamin dm0 0.0033 0.0236 0.0236
Echinococcus granulosus neurogenic locus notch protein 4 0.0052 0.059 0.059
Trypanosoma brucei calpain-like protein, putative 0.004 0.0379 0.212
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0546 0.0975
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0112 0.17 0.17
Echinococcus granulosus delta-like protein 1 0.0052 0.059 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0212 0.0406
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0183 0.0715
Schistosoma mansoni notch 0.0052 0.059 0.1088
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0613 0.12
Schistosoma mansoni hypothetical protein 0.0313 0.5419 1
Brugia malayi Calcium binding EGF domain containing protein 0.0136 0.2139 0.4317
Plasmodium vivax vivapain-2 0.0053 0.0613 0.9512
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0613 0.3552
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0323 0.0323
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0212 0.0371
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0025 0.0095 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0613 0.3552
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0526 0.0971
Echinococcus granulosus calpain A 0.004 0.0379 0.0379
Echinococcus multilocularis fat cadherin tumor suppressor 0.0052 0.059 0.059
Brugia malayi Trypsin family protein 0.0025 0.0095 0.0127
Echinococcus multilocularis geminin 0.0167 0.2711 0.2711
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0095 0.0175
Schistosoma mansoni hypothetical protein 0.0301 0.5199 0.9593
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0307 0.062
Schistosoma mansoni immunophilin 0.0047 0.0504 0.093
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0073 0.0084
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0176 0.0875
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0212 0.11
Onchocerca volvulus Neurogenic locus notch homolog 0.0052 0.059 0.1306
Brugia malayi Calcium binding EGF domain containing protein 0.0052 0.059 0.1142
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0212 0.2945
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0055 0.0643 0.1377
Leishmania major cysteine peptidase A (CPA) 0.0053 0.0613 0.3552
Loa Loa (eye worm) hypothetical protein 0.0031 0.0211 0.0355
Echinococcus multilocularis protein jagged 1 0.0052 0.059 0.059
Leishmania major peptidylprolyl isomerase-like protein 0.0055 0.0643 0.3734
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0643 0.1261
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0055 0.0643 0.1251
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0613 0.131
Brugia malayi Trypsin-like protease protein 5 0.0025 0.0095 0.0127
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Schistosoma mansoni hypothetical protein 0.0104 0.1557 0.2874
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0183 0.034
Schistosoma mansoni notch 0.0052 0.059 0.1088
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0211 0.0366
Plasmodium falciparum importin beta, putative 0.0029 0.0176 0.2343
Loa Loa (eye worm) calpain family protein 1 0.0079 0.1089 0.198
Brugia malayi EGF-like domain containing protein 0.0052 0.059 0.1142
Echinococcus granulosus laminin 0.0136 0.2139 0.2139
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0099 0.1465 0.3231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0613 0.131
Echinococcus multilocularis snurportin 1 0.0313 0.5419 0.5419
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0056 0.0056
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.3368 0.6201
Onchocerca volvulus 0.0053 0.0613 0.1369
Loa Loa (eye worm) beta-lactamase 0.0036 0.0307 0.0533
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Leishmania major cathepsin L-like protease 0.0053 0.0613 0.3552
Loa Loa (eye worm) hypothetical protein 0.0032 0.0225 0.0379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.034 0.0693
Schistosoma mansoni inhibitor of apoptosis protein 0.0104 0.1557 0.2874
Loa Loa (eye worm) hypothetical protein 0.0025 0.0095 0.0139
Leishmania major hypothetical protein, conserved 0.0025 0.0088 0.0341
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0323 0.4758
Leishmania major cathepsin L-like protease 0.0053 0.0613 0.3552
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0053 0.0613 0.9512
Echinococcus multilocularis apoptotic protease activating factor 1 0.0034 0.0261 0.0261
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0751 0.0751
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0323 0.0942
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.065 0.065
Brugia malayi calpain family protein 1 0.0107 0.161 0.3233
Schistosoma mansoni hypothetical protein 0.0052 0.059 0.1088
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0613 0.0613
Onchocerca volvulus 0.0053 0.0613 0.1369
Loa Loa (eye worm) hypothetical protein 0.0107 0.161 0.2945
Echinococcus multilocularis hypothetical protein 0.004 0.0379 0.0379
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0613 0.131
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0533
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Echinococcus granulosus protein jagged 2 0.0052 0.059 0.059
Echinococcus multilocularis cysteine protease 0.0053 0.0613 0.0613
Trichomonas vaginalis fk506-binding protein, putative 0.0055 0.0643 0.1377
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.065 0.065
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0379 0.0716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0613 0.3552
Echinococcus multilocularis cathepsin b 0.0284 0.4874 0.4874
Echinococcus granulosus apoptotic protease activating factor 1 0.0034 0.0261 0.0261
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0183 0.0921
Brugia malayi phosphofructokinase 0.011 0.1668 0.3351
Onchocerca volvulus 0.0053 0.0613 0.1369
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.004 0.0379 0.212
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0307 0.062
Leishmania major fk506-binding protein 1-like protein 0.0055 0.0643 0.3734
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.071 0.1389
Schistosoma mansoni calpain (C02 family) 0.004 0.0379 0.07
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Echinococcus granulosus cathepsin l1 0.0038 0.034 0.034
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0053 0.0613 0.9512
Brugia malayi intermediate filament protein 0.0033 0.0236 0.0416
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.329 0.329
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0643 0.1261
Loa Loa (eye worm) hypothetical protein 0.0136 0.2139 0.3925
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.0379 0.212
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0025 0.0095 0.0127
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1668 0.3052
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0323 0.1777
Brugia malayi Importin beta-1 subunit 0.0029 0.0176 0.0293
Echinococcus granulosus fibropellin Ia 0.0052 0.059 0.059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0454 0.0865
Leishmania major cathepsin L-like protease 0.0053 0.0613 0.3552
Loa Loa (eye worm) hypothetical protein 0.0099 0.1459 0.2666
Brugia malayi hypothetical protein 0.0034 0.0261 0.0469
Echinococcus multilocularis cathepsin L 0.0031 0.0212 0.0212
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.5419 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0095 0.0175
Onchocerca volvulus Putative cubilin 0.0052 0.059 0.1306
Schistosoma mansoni hypothetical protein 0.0025 0.0095 0.0175
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0055 0.0643 0.1251
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0104 0.1557 0.1557
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.329 0.329
Schistosoma mansoni importin beta-1 0.0029 0.0176 0.0324
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0613 0.3552
Trypanosoma brucei calpain-like protein, putative 0.004 0.0379 0.212
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0284 0.4874 0.8993
Echinococcus multilocularis cathepsin b 0.0284 0.4874 0.4874
Onchocerca volvulus Deterin homolog 0.0104 0.1557 0.386
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0613 0.131
Echinococcus granulosus cathepsin l cysteine peptidase 0.0053 0.0613 0.0613
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0095 0.0095
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0379 0.0716
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.4466 1
Brugia malayi 6-phosphofructokinase 0.011 0.1668 0.3351
Echinococcus multilocularis calpain 5 0.004 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0025 0.0095 0.0139
Loa Loa (eye worm) hypothetical protein 0.0136 0.2139 0.3925
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0095 0.0175
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.4466 1
Echinococcus multilocularis laminin 0.0136 0.2139 0.2139
Echinococcus multilocularis neurogenic locus notch protein 0.0052 0.059 0.059
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.0379 0.212
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0183 0.2467
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0047 0.0504 0.0504
Echinococcus granulosus cysteine protease 0.0031 0.0212 0.0212
Echinococcus granulosus glycoprotein Antigen 5 0.0025 0.0095 0.0095
Leishmania major importin beta-1 subunit, putative 0.0024 0.0073 0.0248
Schistosoma mansoni immunophilin 0.0055 0.0643 0.1187
Schistosoma mansoni hypothetical protein 0.0167 0.2711 0.5003
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0183 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0104 0.1557 0.3125
Trichomonas vaginalis esterase, putative 0.0036 0.0307 0.062
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0613 0.1369
Schistosoma mansoni notch 0.0052 0.059 0.1088
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0323 0.1777
Schistosoma mansoni hypothetical protein 0.0031 0.0211 0.039
Brugia malayi Bromodomain containing protein 0.0039 0.035 0.0651
Brugia malayi Calcium binding EGF domain containing protein 0.0052 0.059 0.1142
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1459 0.2924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0055 0.0643 0.0643
Echinococcus granulosus transmembrane protease serine 3 0.0025 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0048 0.0526 0.0938
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.4466 1
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0104 0.1557 0.1557
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0095 0.0175
Echinococcus granulosus protein jagged 1 0.0052 0.059 0.059
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.3938 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0169 0.0169
Plasmodium vivax vivapain-2 0.0053 0.0613 0.9512
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0047 0.0504 0.0504
Loa Loa (eye worm) FKBP5 protein 0.0055 0.0643 0.1154
Onchocerca volvulus 0.0036 0.0307 0.0562
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0183 0.0715
Mycobacterium ulcerans hypothetical protein 0.0036 0.0307 0.1353
Onchocerca volvulus 0.0052 0.059 0.1306
Brugia malayi EGF-like domain containing protein 0.0052 0.059 0.1142
Loa Loa (eye worm) calpain family protein 1 0.0107 0.161 0.2945
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0454 0.0454
Echinococcus multilocularis Tolloid protein 1 0.0136 0.2139 0.2139
Trypanosoma cruzi kinesin, putative 0.0028 0.0155 0.0253
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0454 0.0454
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2804 0.6252
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1459 0.2666
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0169 0.0312
Brugia malayi Delta serrate ligand family protein 0.0052 0.059 0.1142
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Brugia malayi Cell death protein 3 precursor 0.0034 0.0261 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0613 0.12
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.034 0.0627
Schistosoma mansoni notch 0.0052 0.059 0.1088
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0169 0.0649
Echinococcus granulosus snurportin 1 0.0313 0.5419 0.5419
Schistosoma mansoni cell polarity protein 0.0052 0.059 0.1088
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0183 0.2467
Toxoplasma gondii ABC1 family protein 0.0036 0.0307 0.1305
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0526 0.0526
Leishmania major ATP-dependent phosphofructokinase 0.011 0.1668 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0307 0.0568
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0307 0.062
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0613 0.12
Schistosoma mansoni hypothetical protein 0.0052 0.059 0.1088
Loa Loa (eye worm) hypothetical protein 0.0067 0.0865 0.1565
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0212 0.0369
Echinococcus multilocularis notch 0.0052 0.059 0.059
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0095 0.0175
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.015 0.015
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1668 0.3688
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0488 0.0488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Loa Loa (eye worm) hypothetical protein 0.0025 0.0095 0.0139
Echinococcus multilocularis musashi 0.0033 0.0236 0.0236
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.4466 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0088 0.0913
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Echinococcus granulosus geminin 0.0167 0.2711 0.2711
Plasmodium vivax vivapain-1 0.0031 0.0212 0.2945
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0526 0.0526
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0526 0.0971
Echinococcus granulosus neurogenic locus notch protein 0.0052 0.059 0.059
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0052 0.059 0.1142
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0379 0.0716
Echinococcus multilocularis glycoprotein Antigen 5 0.0025 0.0095 0.0095
Schistosoma mansoni bromodomain containing protein 0.0064 0.0818 0.1509
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0052 0.059 0.1088
Brugia malayi Cathepsin L-like precursor 0.0053 0.0613 0.119
Schistosoma mansoni lamin 0.0033 0.0236 0.0435
Echinococcus multilocularis protein jagged 1 0.0052 0.059 0.059
Loa Loa (eye worm) hypothetical protein 0.0041 0.0396 0.0697
Schistosoma mansoni ap endonuclease 0.0037 0.0323 0.0596
Schistosoma mansoni Mername-AA248 (C02 family) 0.004 0.0379 0.07
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0055 0.065 0.1167
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Echinococcus granulosus cathepsin b 0.0284 0.4874 0.4874
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0112 0.17 0.3136
Loa Loa (eye worm) hypothetical protein 0.0104 0.1557 0.2848
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0613 0.3552
Echinococcus multilocularis inhibitor of apoptosis protein 0.0104 0.1557 0.1557
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0176 0.0679
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0643 0.1261
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0323 0.0655
Trypanosoma brucei calpain-like protein, putative 0.004 0.0379 0.212
Toxoplasma gondii calcium binding egf domain-containing protein 0.0136 0.2139 1
Schistosoma mansoni hypothetical protein 0.0034 0.0261 0.0482
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0307 0.0568
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0112 0.17 0.17
Echinococcus multilocularis fibropellin Ia 0.0052 0.059 0.059
Brugia malayi Muscle positioning protein 4 0.0052 0.059 0.1142
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0613 0.1132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0454 0.0454
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.034 0.0693
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.065 0.1199
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0882 0.174
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0307 0.0307
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0379 0.0716
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0613 0.12
Echinococcus granulosus cathepsin L 0.0031 0.0212 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0454 0.0454
Schistosoma mansoni ran 0.0022 0.0033 0.006
Giardia lamblia Cathepsin B precursor 0.0099 0.1465 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0957 0.1736
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0323 0.5
Schistosoma mansoni hypothetical protein 0.0052 0.059 0.1088
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.065 0.1265
Plasmodium falciparum cysteine proteinase falcipain 3 0.0053 0.0613 0.9512
Entamoeba histolytica protein kinase, putative 0.0028 0.0155 0.075
Trichomonas vaginalis immunophilin, putative 0.0055 0.0643 0.1377
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0038 0.034 0.0635
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0212 0.0212
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1668 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0212 0.0392
Echinococcus granulosus Tolloid protein 1 0.0136 0.2139 0.2139
Brugia malayi Cytochrome P450 family protein 0.0049 0.0546 0.1053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0212 0.0406
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0183 0.0715
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0533
Echinococcus granulosus Mastin 0.0025 0.0095 0.0095
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Loa Loa (eye worm) hypothetical protein 0.0146 0.2338 0.4294
Loa Loa (eye worm) hypothetical protein 0.0136 0.2139 0.3925
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0593
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2804 0.6252
Echinococcus granulosus inhibitor of apoptosis protein 0.0104 0.1557 0.1557
Brugia malayi hypothetical protein 0.0025 0.0095 0.0127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0613 0.131
Brugia malayi mbt repeat family protein 0.0048 0.0526 0.1012
Brugia malayi beta-lactamase 0.0036 0.0307 0.0563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0307 0.4501
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0055 0.0643 0.4262
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0212 0.11
Loa Loa (eye worm) hypothetical protein 0.0039 0.0352 0.0615
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0055 0.0643 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0095 0.0175
Schistosoma mansoni hypothetical protein 0.0052 0.059 0.1088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0323 0.06
Loa Loa (eye worm) hypothetical protein 0.0136 0.2139 0.3925
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0088 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0613 0.131
Leishmania major cathepsin L-like protease 0.0053 0.0613 0.3552
Loa Loa (eye worm) hypothetical protein 0.0025 0.0095 0.0139
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0095 0.0175
Schistosoma mansoni hypothetical protein 0.0031 0.0211 0.039
Brugia malayi hypothetical protein 0.0146 0.2338 0.4726
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2975 0.6637
Loa Loa (eye worm) hypothetical protein 0.0034 0.0261 0.0447
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0613 0.131
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0033 0.0024
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.1668 0.3747
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0055 0.0643 0.3098
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.4466 0.8235
Brugia malayi GCC2 and GCC3 family protein 0.0052 0.059 0.1142
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0379 0.0716
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0613 0.0613
Onchocerca volvulus 0.0036 0.0307 0.0562
Leishmania major kinesin, putative 0.0028 0.0155 0.075
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0613 0.1099
Echinococcus granulosus calpain A 0.0112 0.17 0.17
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.1668 0.1668
Loa Loa (eye worm) hypothetical protein 0.0052 0.059 0.1055
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0613 0.1369
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0613 0.3552
Schistosoma mansoni hypothetical protein 0.0052 0.059 0.1088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0454 0.0839
Entamoeba histolytica cysteine protease, putative 0.0031 0.0212 0.11
Loa Loa (eye worm) hypothetical protein 0.0104 0.1557 0.2848
Onchocerca volvulus Cathepsin F homolog 0.0053 0.0613 0.1369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0169 0.0312
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1668 0.3688
Echinococcus multilocularis protein jagged 2 0.0052 0.059 0.059
Schistosoma mansoni hypothetical protein 0.0031 0.0211 0.039
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0236 0.0416
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0613 0.3552
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0212 0.11
Echinococcus multilocularis neurogenic locus notch protein 4 0.0052 0.059 0.059
Onchocerca volvulus 0.0146 0.2338 0.5922
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1668 1
Echinococcus multilocularis calpain 7 (C02 family) 0.004 0.0379 0.0379
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0379 0.0716
Onchocerca volvulus 0.0038 0.034 0.0648
Onchocerca volvulus 0.0029 0.0169 0.0197
Echinococcus multilocularis neurogenic locus protein delta 0.0052 0.059 0.059
Loa Loa (eye worm) hypothetical protein 0.0079 0.1089 0.198
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0073 0.0092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0613 0.131
Loa Loa (eye worm) hypothetical protein 0.0043 0.0432 0.0763
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0643 0.1261
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0284 0.4874 0.8993
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Toxoplasma gondii calcium binding egf domain-containing protein 0.0136 0.2139 1
Echinococcus multilocularis calpain A 0.0112 0.17 0.17
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0055 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.0034 0.0261 0.0447
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0183 0.5
Onchocerca volvulus 0.0033 0.0236 0.0372
Loa Loa (eye worm) hypothetical protein 0.0025 0.0095 0.0139
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0099 0.1465 0.8762
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1668 0.3077
Echinococcus multilocularis neurogenic locus notch protein 0.0052 0.059 0.059
Echinococcus multilocularis cysteine protease 0.0053 0.0613 0.0613
Schistosoma mansoni egf-like domain protein 0.0136 0.2139 0.3947
Onchocerca volvulus 0.0033 0.0236 0.0372
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0307 0.062
Echinococcus granulosus slit 2 protein 0.0052 0.059 0.059
Leishmania major cathepsin L-like protease 0.0053 0.0613 0.3552
Onchocerca volvulus 0.0034 0.0261 0.044
Brugia malayi hypothetical protein 0.0286 0.4912 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0323 0.0562
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0056 0.0102
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0613 0.1132
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0533
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0284 0.4874 0.8993
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0613 0.3552
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0211 0.0366
Onchocerca volvulus 0.0067 0.0865 0.2032
Brugia malayi Fibulin-1 precursor 0.0136 0.2139 0.4317
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0211 0.0355
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0073 0.0092
Onchocerca volvulus 0.0036 0.0307 0.0562
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0183 0.2467
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0307 0.1353
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0055 0.0643 0.3487
Loa Loa (eye worm) ctsf protein 0.0053 0.0613 0.1099
Brugia malayi Pre-SET motif family protein 0.0202 0.3368 0.6836
Loa Loa (eye worm) hypothetical protein 0.0046 0.0488 0.0868
Loa Loa (eye worm) hypothetical protein 0.0286 0.4912 0.906
Schistosoma mansoni calpain C (C02 family) 0.004 0.0379 0.07
Mycobacterium ulcerans lipase LipD 0.0036 0.0307 0.1353
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1668 0.3377
Brugia malayi Cathepsin L-like precursor 0.0053 0.0613 0.119
Loa Loa (eye worm) hypothetical protein 0.0136 0.2139 0.3925
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0643 0.3734
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.2804 0.7151
Trypanosoma brucei calpain-like protein, putative 0.004 0.0379 0.212
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1668 0.3077
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1668 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0323 0.2028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0613 0.131
Schistosoma mansoni survival motor neuron protein 0.0058 0.071 0.1311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0533
Loa Loa (eye worm) notch protein 0.0052 0.059 0.1055
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0136 0.2139 0.3925
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0099 0.1465 0.2704
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0307 0.0567
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0284 0.4874 0.8993
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0183 0.034
Echinococcus granulosus protein jagged 1 0.0052 0.059 0.059
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0136 0.2139 0.3925
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Brugia malayi hypothetical protein 0.0025 0.0088 0.0114
Leishmania major cathepsin L-like protease 0.0053 0.0613 0.3552
Brugia malayi Cadherin domain containing protein 0.0052 0.059 0.1142
Trypanosoma brucei cysteine peptidase C (CPC) 0.0099 0.1465 0.8762
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0088 0.0265
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0533
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0025 0.0095 0.0175
Echinococcus granulosus calpain 7 C02 family 0.004 0.0379 0.0379
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0526 0.1139
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0095 0.0175
Echinococcus multilocularis fibrillin 1 0.0136 0.2139 0.2139
Plasmodium vivax unspecified product 0.0031 0.0212 0.2945
Schistosoma mansoni hypothetical protein 0.0167 0.2711 0.5003
Brugia malayi beta-lactamase family protein 0.0036 0.0307 0.0563
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0183 0.1051
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1668 0.3688
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.4912 0.4912
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0613 0.131
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0112 0.17 0.3136

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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