Detailed information for compound 1349126

Basic information

Technical information
  • TDR Targets ID: 1349126
  • Name: 1-[(2R)-2-[(4-chlorophenyl)methylsulfanyl]-2- (2,4-dichlorophenyl)ethyl]imidazole
  • MW: 397.749 | Formula: C18H15Cl3N2S
  • H donors: 0 H acceptors: 1 LogP: 5.5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CS[C@H](c1ccc(cc1Cl)Cl)Cn1cncc1
  • InChi: 1S/C18H15Cl3N2S/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2/t18-/m0/s1
  • InChiKey: AFNXATANNDIXLG-SFHVURJKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2R)-2-[(4-chlorophenyl)methylthio]-2-(2,4-dichlorophenyl)ethyl]imidazole
  • 1-[(2R)-2-[(4-chlorobenzyl)thio]-2-(2,4-dichlorophenyl)ethyl]imidazole
  • CAS-61318-91-0
  • NCGC00016898-01
  • ZINC03873371

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0094 0.0478 0.0474
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0064 0.0247 0.5701
Echinococcus granulosus biogenic amine 5HT receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.1333 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0097 0.0093
Plasmodium falciparum transporter, putative 0.005 0.0135 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0135 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0064 0.0247 0.0882
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0094 0.0478 0.0474
Brugia malayi G protein-coupled receptor F59B2.13 0.0094 0.0478 0.0474
Echinococcus multilocularis serotonin transporter 0.0292 0.1998 0.1994
Brugia malayi Dopamine receptor 0.0094 0.0478 0.0474
Brugia malayi hypothetical protein 0.005 0.0135 0.0131
Loa Loa (eye worm) TK protein kinase 0.0036 0.0035 0.0035
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0367 1
Echinococcus multilocularis sex peptide receptor 0.0094 0.0478 0.0474
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0097 0.0093
Loa Loa (eye worm) G-protein coupled receptor 0.0094 0.0478 0.0478
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.1998 0.1994
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0094 0.0478 0.0474
Schistosoma mansoni amine GPCR 0.0094 0.0478 0.0474
Onchocerca volvulus 0.0292 0.1998 1
Brugia malayi beta-lactamase 0.0043 0.0088 0.0084
Echinococcus multilocularis Polycystic kidney disease protein 0.0048 0.012 0.0116
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0064 0.0247 0.0882
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0064 0.0247 0.6613
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0064 0.0247 0.6613
Schistosoma mansoni neuropeptide F-like receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0033 0.0005 0.0005
Brugia malayi protein-tyrosine kinase 0.0041 0.007 0.0065
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.007 0.0065
Brugia malayi follicle stimulating hormone receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0005 0.0005
Onchocerca volvulus 0.0094 0.0478 0.2377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0478 0.0474
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0135 0.0131
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.015 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis neuropeptide receptor 0.0094 0.0478 0.0474
Onchocerca volvulus 0.005 0.0135 0.0655
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0064 0.0247 0.0882
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0064 0.0247 0.6613
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Echinococcus granulosus g protein coupled receptor 0.0094 0.0478 0.0474
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0094 0.0478 0.0478
Loa Loa (eye worm) acetyltransferase 0.0175 0.1099 0.1099
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0135 0.0131
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0064 0.0247 0.6613
Echinococcus granulosus peptide allatostatin:somatostatin 0.0094 0.0478 0.0474
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0094 0.0478 0.0474
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0097 0.0325
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0097 0.0325
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0202 0.0197
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0135 0.0131
Echinococcus granulosus sex peptide receptor 0.0094 0.0478 0.0474
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0135 0.0131
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.005 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.1333 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0478 0.0474
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0104 0.0099
Onchocerca volvulus 0.0094 0.0478 0.2377
Plasmodium vivax hypothetical protein, conserved 0.005 0.0135 0.7617
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0064 0.0247 0.6613
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0478 0.0474
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0094 0.0478 0.0474
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0104 0.0099
Brugia malayi hypothetical protein 0.0286 0.1949 0.1945
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.015 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0094 0.0478 0.0474
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.015 1
Onchocerca volvulus 0.0094 0.0478 0.2377
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0064 0.0247 0.0882
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0117 0.2474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Brugia malayi hypothetical protein 0.0094 0.0478 0.0474
Schistosoma mansoni amine GPCR 0.0094 0.0478 0.0474
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0104 0.0099
Onchocerca volvulus 0.0094 0.0478 0.2377
Brugia malayi Serotonin receptor 0.065 0.4747 0.4745
Brugia malayi sulfakinin receptor protein 0.0094 0.0478 0.0474
Schistosoma mansoni hypothetical protein 0.0094 0.0478 0.0474
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1889 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0064 0.0247 0.0882
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0088 0.0084
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0478 0.0474
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0064 0.0247 0.6613
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0097 0.189
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Echinococcus granulosus neuropeptides capa receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis serotonin receptor 0.0094 0.0478 0.0474
Trypanosoma cruzi cytochrome P450, putative 0.0075 0.0328 0.862
Echinococcus granulosus neuropeptide receptor A26 0.0094 0.0478 0.0474
Echinococcus granulosus 7tm_1 domain containing protein 0.0094 0.0478 0.0474
Schistosoma mansoni neuropeptide receptor 0.0094 0.0478 0.0474
Onchocerca volvulus 0.0094 0.0478 0.2377
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.012
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.1998 0.1994
Loa Loa (eye worm) hypothetical protein 0.0594 0.4321 0.4321
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis neuropeptides capa receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) melatonin receptor type 1A 0.0094 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Onchocerca volvulus 0.0094 0.0478 0.2377
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0367 0.0362
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Brugia malayi larval opioid receptor 0.0094 0.0478 0.0474
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.0104 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Onchocerca volvulus 0.0094 0.0478 0.2377
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Brugia malayi Cytochrome P450 family protein 0.011 0.0601 0.0597
Loa Loa (eye worm) TYRA-2 protein 0.0094 0.0478 0.0478
Onchocerca volvulus 0.005 0.0135 0.0655
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0064 0.0247 0.6613
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0064 0.0247 0.0882
Schistosoma mansoni opsin-like receptor 0.0094 0.0478 0.0474
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0064 0.0247 0.5701
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.1998 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0094 0.0478 0.0474
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0094 0.0478 0.0474
Echinococcus granulosus serotonin transporter 0.0292 0.1998 0.1994
Schistosoma mansoni amine GPCR 0.0094 0.0478 0.0474
Loa Loa (eye worm) cytochrome P450 family protein 0.0075 0.0328 0.0328
Loa Loa (eye worm) neuropeptide F receptor 0.0094 0.0478 0.0478
Brugia malayi G-protein coupled receptor 0.0094 0.0478 0.0474
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0064 0.0247 0.6613
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0064 0.0247 0.0882
Echinococcus granulosus tm gpcr rhodopsin 0.0094 0.0478 0.0474
Echinococcus granulosus tm gpcr rhodopsin 0.0094 0.0478 0.0474
Echinococcus granulosus G protein coupled receptor 139 0.0094 0.0478 0.0474
Echinococcus granulosus tachykinin peptides receptor 99D 0.0094 0.0478 0.0474
Plasmodium falciparum LCCL domain-containing protein 0.0048 0.012 0.1829
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Echinococcus multilocularis orexin receptor type 2 0.0094 0.0478 0.0474
Loa Loa (eye worm) cytochrome P450 family protein 0.0075 0.0328 0.0328
Onchocerca volvulus 0.0094 0.0478 0.2377
Echinococcus multilocularis neuropeptide Y receptor 0.0094 0.0478 0.0474
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0367 1
Onchocerca volvulus 0.0094 0.0478 0.2377
Brugia malayi hypothetical protein 0.0094 0.0478 0.0474
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0064 0.0247 0.0882
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Brugia malayi Cytochrome P450 family protein 0.0075 0.0328 0.0324
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Schistosoma mansoni opsin-like receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Echinococcus multilocularis G-protein coupled receptor, putative 0.0094 0.0478 0.0474
Schistosoma mansoni hypothetical protein 0.0058 0.0202 0.0197
Schistosoma mansoni rab6-interacting 0.0048 0.012 0.0116
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0135 0.0131
Brugia malayi hypothetical protein 0.0094 0.0478 0.0474
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0097 0.1474
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.007 0.0065
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.012 0.0116
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.1333 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) TK protein kinase 0.0041 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.1998 0.1998
Brugia malayi beta-lactamase family protein 0.0043 0.0088 0.0084
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.012 0.0116
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0094 0.0478 0.0474
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0005 0.0005
Echinococcus granulosus biogenic amine 5HT receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis fmrfamide receptor 0.0094 0.0478 0.0474
Echinococcus granulosus serotonin receptor 0.0094 0.0478 0.0474
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0064 0.0247 0.0882
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0088
Echinococcus multilocularis somatostatin receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.0035 0.003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0088
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0135 0.0131
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Loa Loa (eye worm) cytochrome P450 0.0064 0.0247 0.0247
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0135 0.0131
Loa Loa (eye worm) G-protein coupled receptor 0.0094 0.0478 0.0478
Echinococcus granulosus hypothetical protein 0.0928 0.6882 0.6881
Brugia malayi putative neuropeptide receptor 0.0094 0.0478 0.0474
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.1333 1 1
Brugia malayi hypothetical protein 0.0048 0.012 0.0116
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0104 0.0099
Echinococcus granulosus RUN 0.0048 0.012 0.0116
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1099 0.1095
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0097 0.0325
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0135 0.0131
Echinococcus multilocularis dro:myosuppressin receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0064 0.0247 0.6613
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0064 0.0247 0.6613
Loa Loa (eye worm) hypothetical protein 0.005 0.0135 0.0135
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.015 0.3869
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0094 0.0478 0.0474
Onchocerca volvulus 0.0043 0.0088 0.0421
Schistosoma mansoni hypothetical protein 0.0064 0.0247 0.0243
Schistosoma mansoni biogenic amine (5HT) receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0367 0.0362
Onchocerca volvulus 0.0048 0.012 0.058
Echinococcus granulosus neuropeptides capa receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.1998 0.1994
Onchocerca volvulus 0.0094 0.0478 0.2377
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1949 0.1945
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0064 0.0247 0.0882
Schistosoma mansoni cytochrome P450 0.0064 0.0247 0.0243
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.007 0.0065
Plasmodium vivax multidomain scavenger receptor, putative 0.0048 0.012 0.5181
Brugia malayi Cytochrome P450 family protein 0.0075 0.0328 0.0324
Brugia malayi beta-lactamase family protein 0.0043 0.0088 0.0084
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0088 0.0084
Brugia malayi AKH receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0292 0.1998 0.1998
Schistosoma mansoni histamine h1 receptor 0.0094 0.0478 0.0474
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1949 0.1945
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis neuropeptide FF receptor 2 0.0094 0.0478 0.0474
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.0035 0.003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0088 0.0088
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0135 0.0131
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0094 0.0478 0.0474
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0209 0.1361 0.1357
Echinococcus granulosus neuropeptide Y receptor 0.0094 0.0478 0.0474
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0064 0.0247 0.6613
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0104 0.0099
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.012 0.0116
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0104 0.0099
Schistosoma mansoni growth hormone secretagogue receptor 0.0094 0.0478 0.0474
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0064 0.0247 0.6613
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Brugia malayi hypothetical protein 0.0094 0.0478 0.0474
Schistosoma mansoni tyrosine kinase 0.0045 0.0104 0.0099
Loa Loa (eye worm) hypothetical protein 0.005 0.0135 0.0135
Echinococcus granulosus fmrfamide receptor 0.0094 0.0478 0.0474
Brugia malayi hypothetical protein 0.0094 0.0478 0.0474
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.015 0.0145
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Schistosoma mansoni hypothetical protein 0.0094 0.0478 0.0474
Onchocerca volvulus 0.0043 0.0088 0.0421
Brugia malayi hypothetical protein 0.0094 0.0478 0.0474
Schistosoma mansoni opsin-like receptor 0.0094 0.0478 0.0474
Onchocerca volvulus 0.0094 0.0478 0.2377
Brugia malayi GnHR receptor homolog 0.0094 0.0478 0.0474
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0094 0.0478 0.0474
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0135 0.0135
Mycobacterium leprae putative cytochrome p450 0.0064 0.0247 1
Echinococcus multilocularis conserved hypothetical protein 0.0833 0.6158 0.6156
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0064 0.0247 0.5701
Schistosoma mansoni biogenic amine receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis allatostatin A receptor 0.0094 0.0478 0.0474
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0064 0.0247 0.6613
Onchocerca volvulus 0.0094 0.0478 0.2377
Echinococcus multilocularis neuropeptide receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis g protein coupled receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0094 0.0478 0.0478
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0104 0.0099
Leishmania major cytochrome p450-like protein 0.0075 0.0328 0.862
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.012 0.0116
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0097 0.0325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0045 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0088
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0097 0.0093
Echinococcus multilocularis G protein coupled receptor 139 0.0094 0.0478 0.0474
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0135 0.0131
Plasmodium falciparum amino acid transporter, putative 0.005 0.0135 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0094 0.0478 0.0474
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0064 0.0247 0.0882
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0094 0.0478 0.0474
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0064 0.0247 0.0882
Brugia malayi Dopamine receptor protein 1 0.0094 0.0478 0.0474
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0075 0.0328 1
Echinococcus multilocularis neuropeptide receptor A26 0.0094 0.0478 0.0474
Echinococcus granulosus allatostatin A receptor 0.0094 0.0478 0.0474
Schistosoma mansoni neuropeptide receptor 0.0094 0.0478 0.0474
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1062 0.1057
Echinococcus granulosus neuropeptide FF receptor 2 0.0094 0.0478 0.0474
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0094 0.0478 0.0474
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1099 0.1095
Schistosoma mansoni hypothetical protein 0.1333 1 1
Brugia malayi G-protein coupled receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) beta-lactamase 0.0043 0.0088 0.0088
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0104 0.0099
Echinococcus granulosus alpha 1A adrenergic receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) serotonin transporter b 0.0292 0.1998 0.1998
Toxoplasma gondii hypothetical protein 0.005 0.0135 0.2947
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0064 0.0247 0.5701
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0094 0.0478 0.0474
Schistosoma mansoni amine GPCR 0.0094 0.0478 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0097 0.0093
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0135 0.0131
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0104 0.0099
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0064 0.0247 0.0882
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0104 0.0099
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0135 0.0131
Loa Loa (eye worm) SRC-1 0.0045 0.0104 0.0104
Echinococcus granulosus neuropeptide receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0094 0.0478 0.0474
Brugia malayi RE15519p 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.005 0.0135 0.0135
Loa Loa (eye worm) neuropeptide F receptor 0.0094 0.0478 0.0478
Brugia malayi hypothetical protein 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0135 0.0131
Brugia malayi hypothetical protein 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0088 0.0084
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Onchocerca volvulus Neuropeptide F receptor homolog 0.0094 0.0478 0.2377
Brugia malayi hypothetical protein 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0104 0.0099
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0094 0.0478 0.0474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0088
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0097 0.0093
Echinococcus granulosus cytochrome P450 2K1 0.0064 0.0247 0.0243
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0094 0.0478 0.0474
Leishmania major cytochrome p450-like protein 0.0064 0.0247 0.5701
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0478 0.0474
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0094 0.0478 0.0474
Echinococcus granulosus orexin receptor type 2 0.0094 0.0478 0.0474
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0064 0.0247 0.5701
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Echinococcus multilocularis RUN 0.0048 0.012 0.0116
Schistosoma mansoni hypothetical protein 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0367 0.0362
Onchocerca volvulus 0.0043 0.0088 0.0421
Echinococcus granulosus tyrosine kinase 0.0041 0.007 0.0065
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0094 0.0478 0.0478
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0135 0.0131
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0097 0.0093
Onchocerca volvulus 0.0094 0.0478 0.2377
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0104 0.0099
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0097 0.1474
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0104 0.0099
Echinococcus multilocularis serotonin receptor 0.0094 0.0478 0.0474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0478 0.0474
Leishmania major cytochrome p450-like protein 0.0064 0.0247 0.5701
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0094 0.0478 0.2377
Brugia malayi neuropeptide F receptor 0.0094 0.0478 0.0474
Schistosoma mansoni biogenic amine (5HT) receptor 0.0094 0.0478 0.0474
Echinococcus granulosus neuropeptide receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0292 0.1998 0.1998
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0064 0.0247 0.6613
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0097 0.0093
Schistosoma mansoni hypothetical protein 0.0048 0.012 0.0116
Brugia malayi Serotonin receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0088
Schistosoma mansoni rab6-interacting 0.0048 0.012 0.0116
Schistosoma mansoni neuropeptide F-like receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Echinococcus multilocularis neuropeptide s receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0135 0.0131
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.005 0.0135 0.5
Onchocerca volvulus 0.0094 0.0478 0.2377
Onchocerca volvulus 0.0094 0.0478 0.2377
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0064 0.0247 0.6613
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0088
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.1998 0.1998
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0109 0.0104
Schistosoma mansoni survival motor neuron protein 0.0058 0.0202 0.0197
Onchocerca volvulus 0.0058 0.0202 0.099
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0135 0.2947
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0094 0.0478 0.0474
Schistosoma mansoni hypothetical protein 0.0094 0.0478 0.0474
Brugia malayi SRC-1 0.0045 0.0104 0.0099
Echinococcus granulosus dro:myosuppressin receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1099 0.1095
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0135 0.0131
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0094 0.0478 0.0478
Schistosoma mansoni lipoxygenase 0.0123 0.0702 0.0698
Echinococcus granulosus tm gpcr rhodopsin 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Brugia malayi G protein-coupled receptor 0.0094 0.0478 0.0474
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0135 0.0131
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0135 0.0131
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0367 1
Echinococcus multilocularis g protein coupled receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0097 0.0093
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0367 1
Brugia malayi neuropeptide F receptor 0.0094 0.0478 0.0474
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0367 0.0362
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0094 0.0478 0.0474
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0104 0.0099
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0064 0.0247 0.0882
Echinococcus multilocularis neuropeptides capa receptor 0.0094 0.0478 0.0474
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0088 0.0084
Brugia malayi cytochrome P450 0.0064 0.0247 0.0243
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0367 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0135 0.0131
Toxoplasma gondii hypothetical protein 0.005 0.0135 0.2947
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0094 0.0478 0.0478
Schistosoma mansoni amine GPCR 0.0094 0.0478 0.0474
Brugia malayi hypothetical protein 0.0094 0.0478 0.0474
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0064 0.0247 0.6613
Brugia malayi putative neuropeptide receptor NPR1 0.0094 0.0478 0.0474
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0104 0.0099
Toxoplasma gondii cytochrome p450 superfamily protein 0.0064 0.0247 1
Schistosoma mansoni biogenic amine receptor 0.0094 0.0478 0.0474
Brugia malayi Doublecortin family protein 0.0048 0.012 0.0116
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0135 0.2947
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0135 0.0131
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0097 0.0093
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0209 0.1361 0.1357
Loa Loa (eye worm) hypothetical protein 0.005 0.0135 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0097 0.1474
Echinococcus multilocularis fmrfamide receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Brugia malayi Melatonin receptor type 1A 0.0094 0.0478 0.0474
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0064 0.0247 0.0882
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0135 0.0131
Schistosoma mansoni neuropeptide receptor 0.0094 0.0478 0.0474
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0064 0.0247 0.0882
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0064 0.0247 0.0882
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0135 0.0131
Onchocerca volvulus 0.0094 0.0478 0.2377
Echinococcus multilocularis neuropeptide Y receptor 0.0094 0.0478 0.0474
Trypanosoma cruzi cytochrome P450, putative 0.0075 0.0328 0.862
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0135 0.0131
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0135 0.0131
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0064 0.0247 0.6613
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0135 0.0131
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0064 0.0247 0.6613
Loa Loa (eye worm) hypothetical protein 0.005 0.0135 0.0135
Echinococcus granulosus g protein coupled receptor 0.0094 0.0478 0.0474
Brugia malayi Tachykinin-like peptides receptor 99D 0.0094 0.0478 0.0474
Echinococcus granulosus neuropeptide s receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0135 0.2947
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0064 0.0247 0.6613
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0135 0.0135
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Onchocerca volvulus 0.0048 0.012 0.058
Schistosoma mansoni myosin xvIII 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Schistosoma mansoni lipoxygenase 0.0209 0.1361 0.1357
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0135 0.0131
Echinococcus granulosus Polycystic kidney disease protein 0.0048 0.012 0.0116
Loa Loa (eye worm) hypothetical protein 0.0594 0.4321 0.4321
Mycobacterium leprae Conserved hypothetical protein 0.0064 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0064 0.0247 0.0882
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0064 0.0247 0.0882
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0367 0.0367
Brugia malayi Dopamine receptor protein 2 0.0094 0.0478 0.0474
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.015 0.3869
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0088 0.0084
Brugia malayi hypothetical protein 0.0048 0.012 0.0116
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.012
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0094 0.0478 0.0474
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0094 0.0478 0.0474
Schistosoma mansoni neuropeptide receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0292 0.1998 0.1998
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0094 0.0478 0.0474
Schistosoma mansoni tyrosine kinase 0.0045 0.0104 0.0099
Brugia malayi ORL1-like opioid receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Echinococcus granulosus g protein coupled receptor 0.0094 0.0478 0.0474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0478 0.0474
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0094 0.0478 0.0474
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0064 0.0247 0.6613
Onchocerca volvulus 0.005 0.0135 0.0655
Loa Loa (eye worm) CYP4Cod1 0.0075 0.0328 0.0328
Loa Loa (eye worm) cytochrome P450 family protein 0.011 0.0601 0.0601
Echinococcus multilocularis 0.0064 0.0247 0.0243
Trypanosoma brucei cytochrome P450, putative 0.0075 0.0328 0.862
Schistosoma mansoni adenoreceptor 0.0094 0.0478 0.0474
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0094 0.0478 0.0474
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0094 0.0478 0.0474
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0104 0.0099
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0094 0.0478 0.0474
Schistosoma mansoni alpha-1 adrenergic receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0286 0.1949 0.1949
Loa Loa (eye worm) doublecortin family protein 0.0048 0.012 0.012
Echinococcus granulosus g-protein coupled receptor 0.0094 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0094 0.0478 0.0478
Schistosoma mansoni polycystin 1-related 0.0048 0.012 0.0116
Echinococcus granulosus somatostatin receptor 0.0094 0.0478 0.0474
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0117 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0064 0.0247 0.0882
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0094 0.0478 0.0474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0478 0.0474
Echinococcus granulosus neuropeptide Y receptor 0.0094 0.0478 0.0474
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0109 0.0104
Plasmodium vivax amine transporter, putative 0.005 0.0135 0.7617
Onchocerca volvulus 0.0094 0.0478 0.2377
Echinococcus multilocularis g protein coupled receptor 0.0094 0.0478 0.0474
Brugia malayi Cytochrome P450 family protein 0.0064 0.0247 0.0243
Schistosoma mansoni biogenic amine receptor 0.0094 0.0478 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0478 0.0474
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0094 0.0478 0.0474
Schistosoma mansoni loxhd1 0.0048 0.012 0.0116

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 0.01 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.019952623 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.125892541 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.199526231 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.630957344 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 0.0004 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 0.01 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 0.02 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (ADMET) = 0.1259 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2794 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1028 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 22.6947 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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