Detailed information for compound 1385460

Basic information

Technical information
  • TDR Targets ID: 1385460
  • Name: ethyl 4-{[(4-methylphenyl)sulfonyl]amino}tetr ahydro-1(2H)-pyridinecarboxylate
  • MW: 326.411 | Formula: C15H22N2O4S
  • H donors: 1 H acceptors: 3 LogP: 2.07 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)N1CCC(CC1)NS(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C15H22N2O4S/c1-3-21-15(18)17-10-8-13(9-11-17)16-22(19,20)14-6-4-12(2)5-7-14/h4-7,13,16H,3,8-11H2,1-2H3
  • InChiKey: URWYRGONPJCYMU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • HTS 10600
  • ZINC00157703
  • MLS000850478
  • SMR000456496

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0061 0.0061 0.0335
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0031 0.0031
Plasmodium falciparum protein kinase, putative 0.0061 0.0061 0.4565
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0054 0.4019
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Trichomonas vaginalis TK family protein kinase 0.0061 0.0061 0.0273
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0061 0.0061 0.0072
Schistosoma mansoni serine/threonine-protein kinase 0.0097 0.0131 0.0131
Echinococcus granulosus G protein coupled receptor kinase 1 0.3098 0.6021 0.7194
Trypanosoma brucei protein kinase, putative 0.0097 0.0131 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Echinococcus multilocularis Immunoglobulin 0.0118 0.0174 0.0208
Onchocerca volvulus 0.0061 0.0061 0.0335
Schistosoma mansoni protein kinase 0.0081 0.0101 0.0101
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0076 0.0091 0.0109
Echinococcus multilocularis dynamin 1 0.0076 0.0091 0.0109
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Entamoeba histolytica protein kinase , putative 0.0084 0.0106 0.0303
Entamoeba histolytica PH domain containing protein kinase, putative 0.0097 0.0131 0.0468
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.5127 1 1
Loa Loa (eye worm) hypothetical protein 0.0831 0.1572 0.1572
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0061 0.0072
Brugia malayi Uncoordinated protein 104 0.0076 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Echinococcus granulosus Regulator of G protein signaling 20 0.0831 0.1572 0.1879
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0061 0.0061 0.0061
Brugia malayi hypothetical protein 0.0404 0.0735 0.0735
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus granulosus fibroblast growth factor receptor 4 0.0061 0.0061 0.0072
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0177 0.0289 0.151
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Plasmodium vivax glutathione reductase, putative 0.0057 0.0054 0.4019
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Entamoeba histolytica hypothetical protein 0.0076 0.0091 0.0202
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Entamoeba histolytica protein kinase domain containing protein 0.0084 0.0106 0.0303
Entamoeba histolytica PH domain containing protein 0.0076 0.0091 0.0202
Schistosoma mansoni dynamin 0.0076 0.0091 0.0091
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0084 0.0106 0.0127
Echinococcus multilocularis plexin a4 0.113 0.2159 0.2579
Loa Loa (eye worm) hypothetical protein 0.0219 0.0371 0.0371
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0061 0.0061 0.0061
Echinococcus granulosus retinal guanylyl cyclase 2 0.0061 0.0061 0.0072
Trypanosoma cruzi Protein kinase B 0.0097 0.0131 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0831 0.1572 0.1572
Echinococcus multilocularis protein kinase 0.0061 0.0061 0.0072
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0076 0.0091 0.6907
Trypanosoma cruzi PH domain containing protein, putative 0.0076 0.0091 0.6907
Brugia malayi plexin A 0.113 0.2159 0.2159
Echinococcus granulosus c src tyrosine kinase 0.0061 0.0061 0.0072
Loa Loa (eye worm) rho-GTPase-activating 0.0076 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Loa Loa (eye worm) TK/INSR protein kinase 0.0061 0.0061 0.0061
Echinococcus multilocularis tyrosine protein kinase pr2 0.0061 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0084 0.0106 0.0303
Toxoplasma gondii aurora kinase 0.0084 0.0106 0.8081
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0076 0.0091 0.6907
Onchocerca volvulus 0.0061 0.0061 0.0335
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Schistosoma mansoni protein kinase 0.0061 0.0061 0.0061
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0076 0.0091 0.0109
Brugia malayi Tyrosine-protein kinase abl-1 0.0061 0.0061 0.0061
Onchocerca volvulus 0.0061 0.0061 0.0335
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Brugia malayi PH domain containing protein 0.0076 0.0091 0.0091
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Echinococcus granulosus oxysterol binding protein 1 0.0076 0.0091 0.0109
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0084 0.0106 0.0303
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0061 0.0061 0.0072
Brugia malayi Variant SH3 domain containing protein 0.0076 0.0091 0.0091
Brugia malayi PH domain containing protein 0.0076 0.0091 0.0091
Entamoeba histolytica PH domain containing protein kinase, putative 0.0097 0.0131 0.0468
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Echinococcus multilocularis natriuretic peptide receptor 1 0.0061 0.0061 0.0072
Echinococcus multilocularis insulin receptor 0.0061 0.0061 0.0072
Loa Loa (eye worm) TK/CSK protein kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Trypanosoma brucei trypanothione reductase 0.0057 0.0054 0.4019
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0831 0.1572 0.1879
Toxoplasma gondii phosphatidylinositol transfer protein 0.0076 0.0091 0.6907
Echinococcus granulosus retinal guanylyl cyclase 2 0.0061 0.0061 0.0072
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) RGC/RGC protein kinase 0.0061 0.0061 0.0061
Toxoplasma gondii protein kinase 0.0061 0.0061 0.4565
Loa Loa (eye worm) hypothetical protein 0.0177 0.0289 0.0289
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0179 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0404 0.0735 0.0735
Brugia malayi hypothetical protein 0.0404 0.0735 0.0735
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Loa Loa (eye worm) TK protein kinase 0.0061 0.0061 0.0061
Brugia malayi hypothetical protein 0.0831 0.1572 0.1572
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0091 0.0202
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0076 0.0091 0.0109
Echinococcus multilocularis Regulator of G protein signaling 20 0.0831 0.1572 0.1879
Schistosoma mansoni hypothetical protein 0.0076 0.0091 0.0091
Brugia malayi probable spectrin beta chain 0.0076 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0097 0.0131 1
Entamoeba histolytica hypothetical protein 0.0097 0.0131 0.0468
Schistosoma mansoni hypothetical protein 0.0177 0.0289 0.0289
Brugia malayi Thioredoxin reductase 0.0057 0.0054 0.0054
Loa Loa (eye worm) AUR protein kinase 0.0084 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 0.0061 0.0072
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0831 0.1572 0.1572
Schistosoma mansoni oxysterol-binding protein 1 0.0076 0.0091 0.0091
Loa Loa (eye worm) TK/EPH protein kinase 0.0061 0.0061 0.0061
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0061 0.0061 0.0072
Loa Loa (eye worm) AGC/AKT protein kinase 0.0097 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0226 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0076 0.0091 0.0503
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Schistosoma mansoni serine/threonine protein kinase 0.5127 1 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0061 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis centaurin beta, putative 0.0076 0.0091 0.047
Onchocerca volvulus 0.0061 0.0061 0.0335
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Echinococcus granulosus axis inhibition protein axin 0.0831 0.1572 0.1879
Schistosoma mansoni dynamin 0.0076 0.0091 0.0091
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Echinococcus granulosus epidermal growth factor receptor 0.0061 0.0061 0.0072
Loa Loa (eye worm) TK protein kinase 0.0061 0.0061 0.0061
Echinococcus multilocularis calcium dependent secretion activator 1 0.0076 0.0091 0.0109
Brugia malayi Regulator of G protein signaling domain containing protein 0.0831 0.1572 0.1572
Loa Loa (eye worm) RGC/RGC protein kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) TK protein kinase 0.0061 0.0061 0.0061
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0024 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0061 0.0273
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Echinococcus granulosus tyrosine protein kinase 0.0061 0.0061 0.0072
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.393 0.7652 0.7652
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Echinococcus granulosus Oxysterol binding protein 11 0.0076 0.0091 0.0109
Entamoeba histolytica protein kinase, putative 0.0084 0.0106 0.0303
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis oxysterol binding protein 1 0.0076 0.0091 0.0109
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0061 0.0061 0.0072
Echinococcus multilocularis protein KINase family member (kin 25) 0.0061 0.0061 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0831 0.1572 1
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0076 0.0091 0.6907
Plasmodium falciparum tyrosine kinase-like protein 0.0061 0.0061 0.4565
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0177 0.0289 0.1742
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0076 0.0091 0.0091
Echinococcus granulosus tyrosine kinase 0.0061 0.0061 0.0072
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0061 0.0061 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Brugia malayi Tyrosine-protein kinase PR2 0.0061 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0061 0.0273
Entamoeba histolytica protein kinase, putative 0.0097 0.0131 0.0468
Echinococcus multilocularis activated cdc42 kinase 1 0.0061 0.0061 0.0072
Echinococcus granulosus aurora kinase A 0.0084 0.0106 0.0127
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0097 0.0131 1
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0076 0.0091 0.0091
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Loa Loa (eye worm) hypothetical protein 0.0831 0.1572 0.1572
Brugia malayi Regulator of G protein signaling domain containing protein 0.0831 0.1572 0.1572
Echinococcus granulosus tyrosine protein kinase Blk 0.0061 0.0061 0.0072
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0197 0.8342
Echinococcus multilocularis activin receptor type 0.0081 0.0101 0.0121
Brugia malayi Raf kinase 0.0061 0.0061 0.0061
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0097 0.0131 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0097 0.0131 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0024 0.0028
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0061 0.0061 0.0061
Echinococcus granulosus regulator of G protein signaling 3 0.0831 0.1572 0.1879
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Leishmania major folate/biopterin transporter, putative 0.0097 0.0131 1
Echinococcus multilocularis neuroglian 0.0118 0.0174 0.0208
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0076 0.0091 0.6907
Echinococcus multilocularis myotubularin protein 13 0.0076 0.0091 0.0109
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0118 0.0174 0.0208
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0091 0.6907
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0177 0.0289 0.1742
Echinococcus multilocularis tyrosine protein kinase csk 0.0061 0.0061 0.0072
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0177 0.0289 0.1742
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Entamoeba histolytica protein kinase, putative 0.0084 0.0106 0.0303
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Brugia malayi Cytohesin 3 0.0076 0.0091 0.0091
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0097 0.0131 0.0729
Brugia malayi Protein kinase domain containing protein 0.0097 0.0131 0.0131
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0831 0.1572 0.1879
Leishmania major protein kinase, putative 0.0081 0.0101 0.7657
Loa Loa (eye worm) uncoordinated protein 104 0.0076 0.0091 0.0091
Entamoeba histolytica hypothetical protein 0.0177 0.0289 0.151
Echinococcus multilocularis regulator of G protein signaling 7 0.0831 0.1572 0.1879
Entamoeba histolytica tyrosin kinase, putative 0.0238 0.0408 0.2298
Onchocerca volvulus 0.0076 0.0091 0.0503
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Brugia malayi PH domain containing protein 0.0076 0.0091 0.0091
Echinococcus multilocularis semaphorin 5B 0.0404 0.0735 0.0878
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus granulosus plexin a4 0.113 0.2159 0.2579
Schistosoma mansoni serine/threonine protein kinase 0.393 0.7652 0.7652
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0054 0.0064
Loa Loa (eye worm) hypothetical protein 0.0404 0.0735 0.0735
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0061 0.0061 0.0072
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Loa Loa (eye worm) PXA domain-containing protein 0.0831 0.1572 0.1572
Echinococcus granulosus defective proboscis extension response 0.0118 0.0174 0.0208
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0076 0.0091 0.0202
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Echinococcus multilocularis Ras associated and pleckstrin y 0.0076 0.0091 0.0109
Echinococcus granulosus transcription factor collier 0.0177 0.0289 0.0345
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Loa Loa (eye worm) RGS-3 protein 0.0831 0.1572 0.1572
Schistosoma mansoni plexin 0.0549 0.1018 0.1018
Schistosoma mansoni hypothetical protein 0.0061 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0118 0.0174 0.0174
Trichomonas vaginalis kinesin light chain, putative 0.0076 0.0091 0.047
Echinococcus granulosus semaphorin 5B 0.0404 0.0735 0.0878
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0197 0.8342
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0061 0.0061 0.0335
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0081 0.0101 0.0121
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0061 0.0061 0.0061
Echinococcus multilocularis transcription factor collier 0.0177 0.0289 0.0345
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Schistosoma mansoni protein kinase 0.0061 0.0061 0.0061
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0831 0.1572 0.1572
Echinococcus granulosus tyrosine kinase 0.0061 0.0061 0.0072
Entamoeba histolytica hypothetical protein 0.0076 0.0091 0.0202
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0568
Schistosoma mansoni serine/threonine protein kinase 0.393 0.7652 0.7652
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0091 0.0202
Brugia malayi Plexin repeat family protein 0.0953 0.1811 0.1811
Loa Loa (eye worm) hypothetical protein 0.0549 0.1018 0.1018
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0061 0.0273
Schistosoma mansoni protein kinase 0.0081 0.0101 0.0101
Entamoeba histolytica hypothetical protein 0.0831 0.1572 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0061 0.0061 0.0061
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0091 0.0202
Echinococcus granulosus tyrosine protein kinase Srms 0.0061 0.0061 0.0072
Echinococcus multilocularis tyrosine protein kinase Blk 0.0061 0.0061 0.0072
Brugia malayi hypothetical protein 0.0061 0.0061 0.0061
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0061 0.0061 0.0273
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.0177 0.0289 0.151
Brugia malayi Immunoglobulin I-set domain containing protein 0.0061 0.0061 0.0061
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0091 0.0202
Brugia malayi IPT/TIG domain containing protein 0.0177 0.0289 0.0289
Plasmodium falciparum oxysterol-binding protein, putative 0.0076 0.0091 0.6907
Giardia lamblia Aurora kinase 0.0084 0.0106 1
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) TK/ALK protein kinase 0.031 0.0549 0.0549
Loa Loa (eye worm) RGC/RGC protein kinase 0.0061 0.0061 0.0061
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0061 0.0061 0.0072
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis Immunoglobulin 0.0118 0.0174 0.0208
Echinococcus granulosus expressed protein 0.0831 0.1572 0.1879
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0097 0.0131 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0081 0.0101 0.7657
Loa Loa (eye worm) hypothetical protein 0.0123 0.0184 0.0184
Entamoeba histolytica protein kinase, putative 0.0097 0.0131 0.0468
Loa Loa (eye worm) TK/ABL protein kinase 0.0061 0.0061 0.0061
Echinococcus multilocularis integrin linked protein kinase 0.0061 0.0061 0.0072
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis tyrosine protein kinase csk 0.0061 0.0061 0.0072
Leishmania major protein kinase, putative 0.0097 0.0131 1
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Plasmodium vivax tyrosine kinase-like protein, putative 0.0061 0.0061 0.4565
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0061 0.0061 0.0072
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0076 0.0091 0.0109
Plasmodium falciparum PH domain-containing protein, putative 0.0076 0.0091 0.6907
Echinococcus granulosus natriuretic peptide receptor 1 0.0061 0.0061 0.0072
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Echinococcus granulosus insulin receptor 0.0061 0.0061 0.0072
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Echinococcus multilocularis G protein coupled receptor kinase 1 0.3098 0.6021 0.7194
Echinococcus granulosus exocyst complex component 2 0.0177 0.0289 0.0345
Echinococcus multilocularis epidermal growth factor receptor 0.0061 0.0061 0.0072
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0061 0.0061 0.4565
Echinococcus granulosus integrin linked protein kinase 0.0061 0.0061 0.0072
Brugia malayi Dynamin 0.0076 0.0091 0.0091
Echinococcus multilocularis Pleckstrin y 0.0076 0.0091 0.0109
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Onchocerca volvulus 0.0076 0.0091 0.0503
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 0.0061 0.0072
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0061 0.0061 0.4565
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0061 0.0061 0.0072
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0054 0.4019
Echinococcus granulosus Pleckstrin y 0.0076 0.0091 0.0109
Schistosoma mansoni goodpasture antigen-binding protein 0.0076 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0061 0.0273
Entamoeba histolytica protein kinase, putative 0.0097 0.0131 0.0468
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.4295 0.8369 0.8369
Entamoeba histolytica hypothetical protein 0.0831 0.1572 1
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0076 0.0091 0.0109
Leishmania major hypothetical protein, conserved 0.0076 0.0091 0.6907
Onchocerca volvulus Protein melted homolog 0.0076 0.0091 0.0503
Echinococcus granulosus roundabout 2 0.0123 0.0184 0.022
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0024 0.0024
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Loa Loa (eye worm) hypothetical protein 0.0118 0.0174 0.0174
Echinococcus granulosus GRB2 associated binding protein 3 0.0076 0.0091 0.0109
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Echinococcus granulosus pdz domain containing protein 0.0076 0.0091 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0061 0.0061
Onchocerca volvulus 0.0061 0.0061 0.0335
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0076 0.0091 0.047
Echinococcus granulosus activated cdc42 kinase 1 0.0061 0.0061 0.0072
Echinococcus multilocularis Rho GTPase activating protein 24 0.0076 0.0091 0.0109
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0118 0.0174 0.0174
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0076 0.0091 0.0109
Schistosoma mansoni centaurin alpha 0.0076 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Brugia malayi A-kinase anchor protein 10, precursor 0.0831 0.1572 0.1572
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0226 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0061 0.0061 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0831 0.1572 1
Brugia malayi Plekhf2 protein 0.0076 0.0091 0.0091
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Brugia malayi hypothetical protein 0.0831 0.1572 0.1572
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0076 0.0091 0.0109
Onchocerca volvulus 0.0061 0.0061 0.0335
Echinococcus multilocularis Pleckstrin y 0.0076 0.0091 0.0109
Onchocerca volvulus Tyrosine kinase homolog 0.0061 0.0061 0.0335
Loa Loa (eye worm) TK protein kinase 0.0061 0.0061 0.0061
Echinococcus granulosus protein kinase 0.0061 0.0061 0.0072
Echinococcus multilocularis oxysterol binding protein 3 0.0076 0.0091 0.0109
Entamoeba histolytica hypothetical protein, conserved 0.0076 0.0091 0.0202
Schistosoma mansoni fibrocystin l 0.0177 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0831 0.1572 0.1572
Trypanosoma cruzi protein kinase, putative 0.0061 0.0061 0.4565
Loa Loa (eye worm) TK protein kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis alpha chimerin, putative 0.0076 0.0091 0.047
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.0289 0.1742
Echinococcus granulosus tyrosine protein kinase pr2 0.0061 0.0061 0.0072
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.4295 0.8369 1
Brugia malayi PH domain containing protein 0.0076 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Schistosoma mansoni zinc finger protein 0.0076 0.0091 0.0091
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Echinococcus granulosus tyrosine protein kinase shark 0.0061 0.0061 0.0072
Echinococcus multilocularis G protein coupled receptor kinase 6 0.4295 0.8369 1
Brugia malayi integrin-linked kinase 0.0061 0.0061 0.0061
Echinococcus multilocularis cytohesin 1 0.0076 0.0091 0.0109
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Onchocerca volvulus outspread protein homolog 0.0076 0.0091 0.0503
Schistosoma mansoni protein kinase 0.0081 0.0101 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Toxoplasma gondii hypothetical protein 0.0076 0.0091 0.6907
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0061 0.0061 0.0061
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0076 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0831 0.1572 0.1572
Loa Loa (eye worm) cytohesin 3 0.0076 0.0091 0.0091
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0076 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0404 0.0735 0.0735
Echinococcus granulosus tyrosine protein kinase Lyn 0.0081 0.0101 0.0121
Brugia malayi serine/threonine protein kinase 6 0.0084 0.0106 0.0106
Brugia malayi Immunoglobulin I-set domain containing protein 0.0179 0.0293 0.0293
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Onchocerca volvulus 0.0953 0.1811 1
Schistosoma mansoni regulator of G protein signaling 0.0831 0.1572 0.1572
Trypanosoma cruzi PH domain containing protein, putative 0.0076 0.0091 0.6907
Schistosoma mansoni regulator of G protein signaling 0.0831 0.1572 0.1572
Loa Loa (eye worm) hypothetical protein 0.0118 0.0174 0.0174
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0061 0.0061 0.0061
Onchocerca volvulus 0.0061 0.0061 0.0335
Loa Loa (eye worm) TK/ACK protein kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0831 0.1572 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0061 0.0061 0.0072
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus granulosus regulator of G protein signaling 3 0.0831 0.1572 0.1879
Trypanosoma brucei aurora B kinase 0.0084 0.0106 0.8081
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0084 0.0106 0.8081
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Schistosoma mansoni serine/threonine RGC 0.0061 0.0061 0.0061
Echinococcus multilocularis actin binding protein anillin 0.0076 0.0091 0.0109
Brugia malayi Cadps2 protein 0.0076 0.0091 0.0091
Echinococcus granulosus tyrosine protein kinase HCK 0.0061 0.0061 0.0072
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0076 0.0091 0.6907
Loa Loa (eye worm) TK/ROR protein kinase 0.0061 0.0061 0.0061
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0197 0.8342
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0061 0.0061 0.0072
Onchocerca volvulus 0.0061 0.0061 0.0335
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0061 0.0061 0.0072
Echinococcus granulosus oxysterol binding protein 3 0.0076 0.0091 0.0109
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Brugia malayi Oxysterol-binding protein 0.0076 0.0091 0.0091
Entamoeba histolytica protein kinase, putative 0.0097 0.0131 0.0468
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0076 0.0091 0.6907
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) plexin A 0.113 0.2159 0.2159
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Onchocerca volvulus 0.0076 0.0091 0.0503
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Brugia malayi PH domain containing protein 0.0076 0.0091 0.0091
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0061 0.0061 0.0072
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0226 1
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0097 0.0131 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0061 0.0061 0.0072
Brugia malayi Guanylyl cyclase protein 23 0.0061 0.0061 0.0061
Echinococcus multilocularis hypothetical protein 0.0404 0.0735 0.0878
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Trypanosoma cruzi hypothetical protein 0.0076 0.0091 0.6907
Brugia malayi glutathione reductase 0.0057 0.0054 0.0054
Loa Loa (eye worm) Plekhf2 protein 0.0076 0.0091 0.0091
Schistosoma mansoni nephrin 0.0123 0.0184 0.0184
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0097 0.0131 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0061 0.0061 0.0061
Echinococcus multilocularis axis inhibition protein axin 0.0831 0.1572 0.1879
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0097 0.0131 1
Loa Loa (eye worm) syntrophin-1 0.0076 0.0091 0.0091
Echinococcus multilocularis regulator of G protein signaling 3 0.0831 0.1572 0.1879
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis tyrosine protein kinase HCK 0.0061 0.0061 0.0072
Echinococcus multilocularis Pleckstrin y 0.0076 0.0091 0.0109
Echinococcus multilocularis tyrosine protein kinase csk 0.0061 0.0061 0.0072
Echinococcus multilocularis c src tyrosine kinase 0.0061 0.0061 0.0072
Trypanosoma cruzi hypothetical protein 0.0076 0.0091 0.6907
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0076 0.0091 0.0109
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus granulosus beta 1 syntrophin 0.0076 0.0091 0.0109
Schistosoma mansoni hypothetical protein 0.0404 0.0735 0.0735
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Echinococcus granulosus dynamin 1 0.0076 0.0091 0.0109
Plasmodium falciparum thioredoxin reductase 0.0057 0.0054 0.4019
Toxoplasma gondii Oxysterol-binding protein 0.0076 0.0091 0.6907
Entamoeba histolytica hypothetical protein 0.0076 0.0091 0.0202
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0024 0.0024
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.4295 0.8369 0.8369
Trypanosoma brucei Flagellum attachment zone protein 20 0.0061 0.0061 0.4565
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0076 0.0091 0.0202
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Brugia malayi SH2 domain containing protein 0.0061 0.0061 0.0061
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0061 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0118 0.0174 0.0174
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0084 0.0106 0.0127
Echinococcus granulosus Pleckstrin y 0.0076 0.0091 0.0109
Echinococcus granulosus regulator of G protein signaling 7 0.0831 0.1572 0.1879
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0076 0.0091 0.0091
Trypanosoma cruzi aurora B kinase, putative 0.0084 0.0106 0.8081
Echinococcus granulosus tyrosine kinase 0.0061 0.0061 0.0072
Plasmodium falciparum tyrosine kinase-like protein 0.0061 0.0061 0.4565
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis heat shock protein 70 0.0061 0.0061 0.0072
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Brugia malayi bone morphogenetic protein type 1 receptor 0.0061 0.0061 0.0061
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0097 0.0131 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0097 0.0131 1
Plasmodium falciparum glutathione reductase 0.0057 0.0054 0.4019
Plasmodium vivax PH domain containing protein 0.0076 0.0091 0.6907
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0076 0.0091 0.047
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.0289 0.1742
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Brugia malayi TBC domain containing protein 0.0076 0.0091 0.0091
Brugia malayi hypothetical protein 0.0061 0.0061 0.0061
Loa Loa (eye worm) TK/Met protein kinase 0.0061 0.0061 0.0061
Schistosoma mansoni regulator of G protein signaling 0.0831 0.1572 0.1572
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0061 0.0061 0.0072
Schistosoma mansoni vesicular amine transporter 0.0121 0.0179 0.0179
Echinococcus multilocularis regulator of G protein signaling 7 0.0831 0.1572 0.1879
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0061 0.0061 0.0072
Brugia malayi PXA domain containing protein 0.0831 0.1572 0.1572
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0097 0.0131 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0061 0.0072
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Plasmodium vivax tyrosine kinase-like protein, putative 0.0061 0.0061 0.4565
Loa Loa (eye worm) hypothetical protein 0.0177 0.0289 0.0289
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Echinococcus granulosus semaphorin 1A 0.0404 0.0735 0.0878
Loa Loa (eye worm) TK protein kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0177 0.0289 0.0289
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0076 0.0091 0.0202
Echinococcus granulosus raf serine:threonine protein kinase 0.0061 0.0061 0.0072
Schistosoma mansoni syntrophin 0.0076 0.0091 0.0091
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0081 0.0101 0.7657
Plasmodium falciparum calcium-dependent protein kinase 7 0.0097 0.0131 1
Trichomonas vaginalis conserved hypothetical protein 0.0831 0.1572 1
Loa Loa (eye worm) AUR protein kinase 0.0084 0.0106 0.0106
Schistosoma mansoni protein kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0831 0.1572 0.1572
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0568
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Brugia malayi PXA domain containing protein 0.0831 0.1572 0.1572
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4295 0.8369 0.8369
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0831 0.1572 0.1572
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0084 0.0106 0.0303
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Brugia malayi PH domain containing protein 0.0076 0.0091 0.0091
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0076 0.0091 0.0091
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0061 0.0061 0.0072
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0066 0.0071 0.0084
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0076 0.0091 0.0109
Echinococcus granulosus pleckstrin y domain containing family A 0.0076 0.0091 0.0109
Trichomonas vaginalis hypothetical protein 0.0076 0.0091 0.047
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Loa Loa (eye worm) hypothetical protein 0.0404 0.0735 0.0735
Brugia malayi Sema domain containing protein 0.0404 0.0735 0.0735
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Loa Loa (eye worm) TK/RYK protein kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0076 0.0091 0.047
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0091 0.0202
Schistosoma mansoni serine/threonine-protein kinase 0.0097 0.0131 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0061 0.0061 0.0061
Onchocerca volvulus 0.0404 0.0735 0.4055
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Trypanosoma cruzi hypothetical protein 0.0076 0.0091 0.6907
Echinococcus multilocularis DCC interacting protein 13 beta 0.0076 0.0091 0.0109
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0076 0.0091 0.0109
Trypanosoma cruzi hypothetical protein 0.0076 0.0091 0.6907
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0076 0.0091 0.0202
Brugia malayi MAX-1A 0.0076 0.0091 0.0091
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0061 0.0273
Brugia malayi ephrin receptor 1 precursor 0.0061 0.0061 0.0061
Echinococcus granulosus myotubularin protein 13 0.0076 0.0091 0.0109
Echinococcus granulosus ephrin type A receptor 4 A 0.0061 0.0061 0.0072
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0197 0.8342
Schistosoma mansoni hypothetical protein 0.0076 0.0091 0.0091
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0076 0.0091 0.047
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0091 0.0202
Echinococcus granulosus beta-adrenergic receptor kinase 0.393 0.7652 0.9143
Echinococcus granulosus epidermal growth factor receptor 0.0061 0.0061 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0831 0.1572 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Toxoplasma gondii protein kinase domain-containing protein 0.0097 0.0131 1
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0177 0.0289 0.1742
Echinococcus granulosus DCC interacting protein 13 beta 0.0076 0.0091 0.0109
Loa Loa (eye worm) sema domain-containing protein 0.0404 0.0735 0.0735
Trypanosoma cruzi NIMA-related kinase, putative 0.0097 0.0131 1
Entamoeba histolytica cell surface protease gp63, putative 0.0177 0.0289 0.151
Schistosoma mansoni oxysterol-binding protein 1 0.0076 0.0091 0.0091
Echinococcus multilocularis FL cytokine receptor 0.0061 0.0061 0.0072
Echinococcus multilocularis epidermal growth factor receptor 0.0061 0.0061 0.0072
Entamoeba histolytica PH domain containing protein kinase, putative 0.0097 0.0131 0.0468
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0061 0.0061 0.0061
Brugia malayi Furin-like cysteine rich region family protein 0.0061 0.0061 0.0061
Schistosoma mansoni cell adhesion molecule 0.0123 0.0184 0.0184
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0097 0.0131 1
Brugia malayi regulator of G-protein signaling egl-10 0.0831 0.1572 0.1572
Schistosoma mansoni ephrin receptor 0.0061 0.0061 0.0061
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0177 0.0289 0.1742
Leishmania major hypothetical protein, conserved 0.0076 0.0091 0.6907
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.0289 0.1742
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0061 0.0061 0.0273
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0076 0.0091 0.047
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Echinococcus multilocularis kinase suppressor of Ras 1 0.0061 0.0061 0.0072
Toxoplasma gondii STE kinase 0.0061 0.0061 0.4565
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Loa Loa (eye worm) serine/threonine protein kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0061 0.0061 0.0072
Loa Loa (eye worm) sema domain-containing protein 0.0404 0.0735 0.0735
Brugia malayi Pleckstrin Homology Domain 0.0076 0.0091 0.0091
Entamoeba histolytica PH domain containing protein 0.0076 0.0091 0.0202
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0061 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 0.0061 0.0072
Echinococcus multilocularis axis inhibition protein axin 0.0831 0.1572 0.1879
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0061 0.0061 0.0072
Plasmodium falciparum serine/threonine protein kinase, putative 0.0084 0.0106 0.8081
Onchocerca volvulus 0.0061 0.0061 0.0335
Trypanosoma cruzi hypothetical protein 0.0076 0.0091 0.6907
Loa Loa (eye worm) TK protein kinase 0.0061 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0177 0.0289 0.0289
Trypanosoma brucei protein kinase, putative 0.0081 0.0101 0.7657
Schistosoma mansoni growth factor receptor-bound protein 0.0076 0.0091 0.0091
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Echinococcus granulosus oxysterol binding protein 9 0.0076 0.0091 0.0109
Loa Loa (eye worm) TK protein kinase 0.0061 0.0061 0.0061
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0076 0.0091 0.6907
Schistosoma mansoni hypothetical protein 0.0076 0.0091 0.0091
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0091 0.0202
Echinococcus multilocularis tyrosine protein kinase Abl 0.0061 0.0061 0.0072
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0097 0.0131 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0061 0.0061 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.031 0.0549 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0061 0.0273
Schistosoma mansoni protein kinase 0.0084 0.0106 0.0106
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus granulosus kinase suppressor of Ras 1 0.0061 0.0061 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.0289 0.1742
Echinococcus granulosus cytohesin 1 0.0076 0.0091 0.0109
Schistosoma mansoni regulator of G protein signaling 0.0831 0.1572 0.1572
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Loa Loa (eye worm) hypothetical protein 0.0404 0.0735 0.0735
Leishmania major protein kinase, putative 0.0097 0.0131 1
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0097 0.0131 1
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Onchocerca volvulus 0.0076 0.0091 0.0503
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Plasmodium falciparum protein kinase, putative 0.0061 0.0061 0.4565
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0097 0.0131 1
Echinococcus multilocularis pleckstrin y domain containing family A 0.0076 0.0091 0.0109
Schistosoma mansoni plexin 0.0953 0.1811 0.1811
Echinococcus granulosus activated cdc42 kinase 1 0.0061 0.0061 0.0072
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0118 0.0174 0.0208
Trypanosoma cruzi PH domain containing protein, putative 0.0076 0.0091 0.6907
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0076 0.0091 0.0109
Toxoplasma gondii AtPH1 family protein 0.0076 0.0091 0.6907
Echinococcus granulosus neuroglian 0.0118 0.0174 0.0208
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase ABL1 0.0061 0.0061 0.0072
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0076 0.0091 0.0109
Echinococcus multilocularis receptor type guanylyl cyclase 0.0061 0.0061 0.0072
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Loa Loa (eye worm) TK/EGFR protein kinase 0.0061 0.0061 0.0061
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0076 0.0091 0.6907
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0061 0.0061 0.4565
Leishmania major serine/threonine-protein kinase a, putative 0.0097 0.0131 1
Schistosoma mansoni zinc finger protein 0.0076 0.0091 0.0091
Schistosoma mansoni vav2 0.0076 0.0091 0.0091
Loa Loa (eye worm) TK protein kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Schistosoma mansoni protein kinase 0.0061 0.0061 0.0061
Trypanosoma cruzi NIMA-related kinase, putative 0.0097 0.0131 1
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Schistosoma mansoni protein tyrosine kinase 0.0061 0.0061 0.0061
Entamoeba histolytica ARF GTPase activating protein, putative 0.0076 0.0091 0.0202
Onchocerca volvulus 0.0061 0.0061 0.0335
Toxoplasma gondii thioredoxin reductase 0.0057 0.0054 0.4019
Loa Loa (eye worm) glutathione reductase 0.0057 0.0054 0.0054
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0061 0.0061 0.0061
Echinococcus multilocularis oxysterol binding protein 9 0.0076 0.0091 0.0109
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0076 0.0091 0.0091
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Loa Loa (eye worm) hypothetical protein 0.0953 0.1811 0.1811
Brugia malayi PH domain containing protein 0.0076 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Echinococcus granulosus Pleckstrin y 0.0076 0.0091 0.0109
Echinococcus granulosus Immunoglobulin 0.0118 0.0174 0.0208
Loa Loa (eye worm) hypothetical protein 0.0404 0.0735 0.0735
Trypanosoma brucei rac serine-threonine kinase, putative 0.0097 0.0131 1
Brugia malayi Syntrophin-1 0.0076 0.0091 0.0091
Schistosoma mansoni myotubularin-related protein 0.0076 0.0091 0.0091
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Onchocerca volvulus 0.0061 0.0061 0.0335
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0061 0.0061 0.0072
Loa Loa (eye worm) PH domain-containing protein 0.0076 0.0091 0.0091
Echinococcus multilocularis tyrosine protein kinase 0.0061 0.0061 0.0072
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0076 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Echinococcus multilocularis beta 1 syntrophin 0.0076 0.0091 0.0109
Echinococcus multilocularis transfer RNA-Thr 0.0061 0.0061 0.0072
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Plasmodium falciparum protein kinase, putative 0.0081 0.0101 0.7657
Loa Loa (eye worm) AUR protein kinase 0.0084 0.0106 0.0106
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Schistosoma mansoni protein kinase 0.0061 0.0061 0.0061
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0076 0.0091 0.0091
Echinococcus granulosus activin receptor type 0.0081 0.0101 0.0121
Schistosoma mansoni hypothetical protein 0.0549 0.1018 0.1018
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Schistosoma mansoni protein kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0831 0.1572 0.1572
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0076 0.0091 0.047
Trypanosoma cruzi hypothetical protein 0.0076 0.0091 0.6907
Echinococcus multilocularis tyrosine protein kinase Srms 0.0061 0.0061 0.0072
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0061 0.0061 0.0335
Echinococcus granulosus axis inhibition protein axin 0.0831 0.1572 0.1879
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0076 0.0091 0.0109
Entamoeba histolytica hypothetical protein 0.0177 0.0289 0.151
Schistosoma mansoni axis inhibition protein axin 0.0831 0.1572 0.1572
Schistosoma mansoni regulator of G protein signaling 0.0831 0.1572 0.1572
Brugia malayi PH domain containing protein 0.0076 0.0091 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0106 0.0106
Onchocerca volvulus 0.0035 0.001 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0061 0.0061 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.0289 0.1742
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Brugia malayi hypothetical protein 0.003 0.0001 0.0001
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0097 0.0131 0.0729
Echinococcus multilocularis exocyst complex component 2 0.0177 0.0289 0.0345
Schistosoma mansoni hypothetical protein 0.0404 0.0735 0.0735
Trichomonas vaginalis conserved hypothetical protein 0.0831 0.1572 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Trichomonas vaginalis centaurin/arf, putative 0.0076 0.0091 0.047
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Echinococcus multilocularis rac serine:threonine kinase 0.0097 0.0131 0.0157
Echinococcus granulosus calcium dependent secretion activator 1 0.0076 0.0091 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0061 0.0273
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0076 0.0091 0.0503
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0097 0.0131 1
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0076 0.0091 0.0109
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Brugia malayi Immunoglobulin I-set domain containing protein 0.0123 0.0184 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Schistosoma mansoni goodpasture antigen-binding protein 0.0076 0.0091 0.0091
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0076 0.0091 0.0109
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Trypanosoma cruzi PH domain containing protein, putative 0.0076 0.0091 0.6907
Onchocerca volvulus Putative zinc finger protein 0.0076 0.0091 0.0503
Entamoeba histolytica p21-activated kinase 0.0097 0.0131 0.0468
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0061 0.0061 0.0072
Echinococcus granulosus tyrosine protein kinase csk 0.0061 0.0061 0.0072
Schistosoma mansoni protein kinase 0.0061 0.0061 0.0061
Brugia malayi hypothetical protein 0.0076 0.0091 0.0091
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase csk 0.0061 0.0061 0.0072
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0061 0.0061 0.0072
Brugia malayi SH2 domain containing protein 0.0061 0.0061 0.0061
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0061 0.0061 0.0273
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0081 0.0101 0.7657
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus granulosus serine/threonine protein kinase 0.0097 0.0131 0.0157
Trichomonas vaginalis centaurin gamma, putative 0.0076 0.0091 0.047
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0061 0.0061 0.0273
Onchocerca volvulus 0.0076 0.0091 0.0503
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0097 0.0131 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0081 0.0101 0.7657
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0061 0.0072
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0076 0.0091 0.0109
Loa Loa (eye worm) TK/FAK protein kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0831 0.1572 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Loa Loa (eye worm) hypothetical protein 0.0123 0.0184 0.0184
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0061 0.0061 0.0072
Brugia malayi hypothetical protein 0.0123 0.0184 0.0184
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0076 0.0091 0.6907
Brugia malayi C-terminal src kinase protein 1 0.0061 0.0061 0.0061
Entamoeba histolytica protein kinase, putative 0.0097 0.0131 0.0468
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0118 0.0174 0.0174
Entamoeba histolytica hypothetical protein 0.0076 0.0091 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.0289 0.1742
Leishmania major protein kinase, putative 0.0084 0.0106 0.8081
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Brugia malayi hypothetical protein 0.0061 0.0061 0.0061
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0091 0.0202
Echinococcus granulosus tyrosine protein kinase Src64B 0.0061 0.0061 0.0072
Brugia malayi Sema domain containing protein 0.0404 0.0735 0.0735
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0061 0.0061 0.0061
Echinococcus multilocularis GRB2 associated binding protein 3 0.0076 0.0091 0.0109
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0091 0.0202
Trichomonas vaginalis protein transport protein sec7, putative 0.0076 0.0091 0.047
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0061 0.0061 0.0072
Onchocerca volvulus 0.0061 0.0061 0.0335
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0061 0.0061 0.0072
Brugia malayi DNA-binding protein LAG-1 0.0177 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0118 0.0174 0.0174
Brugia malayi SRC-1 0.0061 0.0061 0.0061
Brugia malayi serine/threonine kinase 12 0.0084 0.0106 0.0106
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0066 0.0071 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Echinococcus multilocularis roundabout 2 0.0123 0.0184 0.022
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Echinococcus multilocularis regulator of G protein signaling 0.0831 0.1572 0.1879
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0061 0.0061 0.0072
Echinococcus granulosus receptor type guanylyl cyclase 0.0061 0.0061 0.0072
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0061 0.0072
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0061 0.0061 0.0072
Schistosoma mansoni tyrosine protein kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0076 0.0091 0.0091
Loa Loa (eye worm) oxysterol binding protein 0.0076 0.0091 0.0091
Echinococcus multilocularis tyrosine kinase 0.0061 0.0061 0.0072
Onchocerca volvulus 0.0061 0.0061 0.0335
Onchocerca volvulus 0.0076 0.0091 0.0503
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0061 0.0061 0.0072
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0061 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Trichomonas vaginalis centaurin alpha, putative 0.0076 0.0091 0.047
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis tyrosine kinase 0.0061 0.0061 0.0072
Schistosoma mansoni semaphorin 5-related 0.0404 0.0735 0.0735
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Loa Loa (eye worm) hypothetical protein 0.0061 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Brugia malayi Dynamin 0.0076 0.0091 0.0091
Brugia malayi protein-tyrosine kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trypanosoma cruzi protein kinase, putative 0.0061 0.0061 0.4565
Brugia malayi serine/threonine-protein kinase 6 0.0084 0.0106 0.0106
Mycobacterium tuberculosis Probable reductase 0.013 0.0197 0.8342
Trichomonas vaginalis protein tyrosine kinase, putative 0.0061 0.0061 0.0273
Brugia malayi Variant SH3 domain containing protein 0.0076 0.0091 0.0091
Trichomonas vaginalis protein transport protein sec7, putative 0.0076 0.0091 0.047
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0076 0.0091 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.0289 0.1742
Echinococcus multilocularis pdz domain containing protein 0.0076 0.0091 0.0109
Echinococcus multilocularis beta adrenergic receptor kinase 0.393 0.7652 0.9143
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0061 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0061 0.0061 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0081 0.0101 0.0121
Entamoeba histolytica PH domain containing protein 0.0076 0.0091 0.0202
Echinococcus multilocularis protein tyrosine kinase 0.0061 0.0061 0.0072
Entamoeba histolytica protein kinase, putative 0.0097 0.0131 0.0468
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0061 0.0061 0.0061
Echinococcus multilocularis Oxysterol binding protein 11 0.0076 0.0091 0.0109
Echinococcus granulosus Rho GTPase activating protein 24 0.0076 0.0091 0.0109
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0076 0.0091 0.0202
Entamoeba histolytica protein kinase, putative 0.0097 0.0131 0.0468
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0118 0.0174 0.0174
Schistosoma mansoni protein kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0123 0.0184 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0076 0.0091 0.0091
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0061 0.0061 0.0072
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0061 0.0061 0.0072
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0061 0.0061 0.0072
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0076 0.0091 0.0202
Echinococcus multilocularis regulator of G protein signaling 3 0.0831 0.1572 0.1879
Schistosoma mansoni ephrin receptor 0.0066 0.0071 0.0071
Entamoeba histolytica protein kinase domain containing protein 0.0081 0.0101 0.0266
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Echinococcus multilocularis tyrosine protein kinase csk 0.0061 0.0061 0.0072
Trypanosoma brucei Pseudokinase, putative 0.0061 0.0061 0.4565
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0054 0.0054
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0061 0.0061 0.0061
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1863 0.2226
Leishmania major trypanothione reductase 0.0057 0.0054 0.4019
Entamoeba histolytica PH domain containing protein kinase, putative 0.0097 0.0131 0.0468
Loa Loa (eye worm) SRC-1 0.0061 0.0061 0.0061
Entamoeba histolytica protein kinase domain containing protein 0.0238 0.0408 0.2298
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0061 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Trypanosoma brucei PH domain containing protein, putative 0.0076 0.0091 0.6907
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0061 0.0061 0.0072
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0061 0.0061 0.0072
Loa Loa (eye worm) TK protein kinase 0.0061 0.0061 0.0061
Echinococcus granulosus protein tyrosine kinase 0.0061 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0177 0.0289 0.0289
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Brugia malayi PH domain containing protein 0.0076 0.0091 0.0091
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trichomonas vaginalis AGC family protein kinase 0.0097 0.0131 0.0729
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0568
Brugia malayi Protein kinase domain containing protein 0.0061 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0061 0.0273
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0061 0.0061 0.0072
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis expressed protein 0.0831 0.1572 0.1879
Toxoplasma gondii protein kinase domain-containing protein 0.0061 0.0061 0.4565
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0831 0.1572 1
Trypanosoma cruzi hypothetical protein 0.0076 0.0091 0.6907
Brugia malayi Receptor family ligand binding region containing protein 0.0061 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0076 0.0091 0.0091
Brugia malayi Probable exocyst complex component Sec5 0.0177 0.0289 0.0289
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Echinococcus multilocularis protein kinase 0.0061 0.0061 0.0072
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0061 0.0061 0.0072
Echinococcus granulosus tyrosine protein kinase Src42A 0.0061 0.0061 0.0072
Echinococcus granulosus regulator of G protein signaling 7 0.0831 0.1572 0.1879
Entamoeba histolytica hypothetical protein 0.0097 0.0131 0.0468
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Brugia malayi Oxysterol binding protein 0.0076 0.0091 0.0091
Brugia malayi Fibronectin type III domain containing protein 0.0123 0.0184 0.0184
Echinococcus multilocularis aurora kinase A 0.0084 0.0106 0.0127
Plasmodium vivax protein kinase, putative 0.0061 0.0061 0.4565
Leishmania major protein kinase, putative 0.0061 0.0061 0.4565
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.0091
Leishmania major hypothetical protein, conserved 0.0061 0.0061 0.4565
Schistosoma mansoni z-protein (S1r protein) 0.0831 0.1572 0.1572
Entamoeba histolytica PH domain containing protein kinase, putative 0.0097 0.0131 0.0468
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0061 0.0061 0.0072
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0054 0.0064
Entamoeba histolytica PH domain containing protein kinase, putative 0.0097 0.0131 0.0468
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0061 0.0273
Echinococcus granulosus tyrosine protein kinase csk 0.0061 0.0061 0.0072
Loa Loa (eye worm) TK/FER protein kinase 0.0061 0.0061 0.0061
Echinococcus granulosus twitchin 0.0139 0.0214 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0091 0.047
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0061 0.0061 0.0072
Toxoplasma gondii hypothetical protein 0.0076 0.0091 0.6907
Trichomonas vaginalis STE family protein kinase 0.0061 0.0061 0.0273
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0226 1
Onchocerca volvulus 0.0076 0.0091 0.0503
Loa Loa (eye worm) hypothetical protein 0.0831 0.1572 0.1572
Schistosoma mansoni rho gtpase activating protein 0.0076 0.0091 0.0091
Schistosoma mansoni axis inhibition protein axin 0.0831 0.1572 0.1572
Trichomonas vaginalis TKL family protein kinase 0.0061 0.0061 0.0273
Trichomonas vaginalis protein kinase atn1, putative 0.0061 0.0061 0.0273
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0197 0.8342
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0568
Schistosoma mansoni tyrosine kinase 0.0061 0.0061 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0061 0.0061
Trichomonas vaginalis centaurin/arf, putative 0.0076 0.0091 0.047
Onchocerca volvulus 0.0061 0.0061 0.0335
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0076 0.0091 0.0091
Loa Loa (eye worm) RGC/RGC protein kinase 0.0061 0.0061 0.0061

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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