Detailed information for compound 1395325

Basic information

Technical information
  • TDR Targets ID: 1395325
  • Name: N-(2,4-dimethoxyphenyl)-3-(4-oxopyrrolo[2,1-c ]quinoxalin-5-yl)propanamide
  • MW: 391.42 | Formula: C22H21N3O4
  • H donors: 1 H acceptors: 2 LogP: 2.5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)OC)NC(=O)CCn1c(=O)c2cccn2c2c1cccc2
  • InChi: 1S/C22H21N3O4/c1-28-15-9-10-16(20(14-15)29-2)23-21(26)11-13-25-18-7-4-3-6-17(18)24-12-5-8-19(24)22(25)27/h3-10,12,14H,11,13H2,1-2H3,(H,23,26)
  • InChiKey: HPYOPCDUJXEYKK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dimethoxyphenyl)-3-(4-oxo-5-pyrrolo[2,1-c]quinoxalinyl)propanamide
  • N-(2,4-dimethoxyphenyl)-3-(4-ketopyrrolo[2,1-c]quinoxalin-5-yl)propionamide
  • NCGC00121426-01
  • E228-1001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0111 0.0341
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0215 0.5932
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0123 0.0207 0.0288
Echinococcus multilocularis 0.009 0.0143 0.0143
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0095 0.0153 0.0152
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0028 0.002 0.0073
Echinococcus multilocularis 0.0028 0.002 0.002
Schistosoma mansoni caspase-3 (C14 family) 0.01 0.0162 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0005 0.0016
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0025 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0215 0.5932
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0028 0.002 0.0073
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0123 0.0207 0.037
Schistosoma mansoni hypothetical protein 0.005 0.0064 0.0113
Schistosoma mansoni tyrosine kinase 0.0095 0.0153 0.0273
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0111 0.0197
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.084 0.1622 0.5922
Leishmania major metacaspase, putative 0.0027 0.0018 0.0063
Echinococcus multilocularis PHD finger protein rhinoceros 0.0061 0.0086 0.0086
Entamoeba histolytica hypothetical protein 0.0028 0.002 0.0073
Toxoplasma gondii thioredoxin reductase 0.0046 0.0056 0.0203
Plasmodium falciparum replication factor C subunit 1, putative 0.0031 0.0027 0.0096
Plasmodium falciparum thioredoxin reductase 0.0046 0.0056 0.0203
Trypanosoma brucei protein kinase, putative 0.0063 0.009 0.0328
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0189 0.0628
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0063 0.009 0.0328
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0025 0.0024
Entamoeba histolytica hypothetical protein 0.0031 0.0027 0.0096
Schistosoma mansoni plexin 0.0023 0.001 0.0017
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0018 0.0063
Echinococcus granulosus plexin a4 0.0046 0.0056 0.01
Plasmodium vivax SET domain protein, putative 0.0061 0.0085 0.0295
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0025 0.0043
Schistosoma mansoni kinase 0.0064 0.0092 0.0164
Onchocerca volvulus 0.0028 0.002 0.001
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0042 0.0088
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0028 0.002 0.002
Loa Loa (eye worm) TK/INSR protein kinase 0.0095 0.0153 0.0543
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0028 0.002 0.0073
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0025 0.0043
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0056 0.0189
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0018 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0189 0.0628
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0027 0.0037
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0025 0.0015
Echinococcus granulosus lamin dm0 0.0028 0.002 0.0035
Entamoeba histolytica hypothetical protein 0.0186 0.0332 0.1212
Onchocerca volvulus 0.003 0.0025 0.0015
Brugia malayi Pax transcription activation domain interacting protein 0.0031 0.0027 0.0037
Loa Loa (eye worm) beta-lactamase 0.0074 0.0111 0.0389
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0306 0.1114
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.0136 0.0136
Brugia malayi Latrophilin receptor protein 2 0.005 0.0064 0.0088
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0202 0.0363 0.1325
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0137
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0053 0.0074
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0028 0.002 0.0073
Loa Loa (eye worm) phosphatidylinositol 3 0.0775 0.1492 0.5442
Loa Loa (eye worm) Ulp1 protease 0.0039 0.0042 0.0137
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0025 0.0043
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0066 0.0241
Mycobacterium ulcerans hypothetical protein 0.0192 0.0344 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0028 0.0049
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0064 0.0113
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0054
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0039 0.0141
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0095 0.0153 0.0273
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0028 0.002 0.0036
Schistosoma mansoni cpg binding protein 0.003 0.0025 0.0045
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0056 0.01
Brugia malayi nuclear hormone receptor 0.003 0.0025 0.0034
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0186 0.0332 0.0594
Giardia lamblia Replication factor C, subunit 1 0.0031 0.0027 0.0023
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0019 0.0068
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0275 0.0507 0.18
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0028 0.002 0.0036
Onchocerca volvulus 0.0061 0.0085 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0025 0.0074
Echinococcus granulosus FTZ F1 alpha 0.003 0.0025 0.0043
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0066 0.0241
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0049
Echinococcus granulosus Niemann Pick C1 protein 0.0288 0.0534 0.0955
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.0276 0.0384
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0336 0.0601
Echinococcus multilocularis neuropeptide receptor A26 0.0934 0.1806 0.1806
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0064 0.1179
Loa Loa (eye worm) hypothetical protein 0.0074 0.0111 0.0389
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0123 0.0207 0.0696
Schistosoma mansoni hypothetical protein 0.0084 0.013 0.0232
Echinococcus granulosus inositol monophosphatase 1 0.0149 0.026 0.0464
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0172 0.1744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Schistosoma mansoni inositol monophosphatase 0.0149 0.026 0.0464
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1407 0.2738 1
Echinococcus granulosus epidermal growth factor receptor 0.0294 0.0544 0.0973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.002 0.0036
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0042 0.0058
Echinococcus granulosus tar DNA binding protein 0.0188 0.0336 0.0601
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0471 0.0893 1
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0025 0.0034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.002 0.0028
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0028 0.002 0.0036
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0042 0.0088
Onchocerca volvulus 0.0074 0.0111 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0027 0.0032
Brugia malayi Pre-SET motif family protein 0.0061 0.0085 0.0118
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0111 0.1034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0027 0.0096
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0172 0.1744
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0086 0.03
Schistosoma mansoni hypothetical protein 0.0032 0.0028 0.0049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0115 0.0205
Brugia malayi hypothetical protein 0.0255 0.0469 0.0652
Loa Loa (eye worm) hypothetical protein 0.0332 0.0619 0.225
Loa Loa (eye worm) Ulp1 protease 0.0092 0.0148 0.0524
Trypanosoma cruzi metacaspase, putative 0.0027 0.0018 0.0063
Brugia malayi hypothetical protein 0.0237 0.0433 0.0602
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.0456 0.1651
Brugia malayi follicle stimulating hormone receptor 0.0478 0.0908 0.1263
Echinococcus multilocularis lysine specific demethylase 5A 0.0074 0.0112 0.0111
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0113 0.0189 0.0687
Onchocerca volvulus 0.0048 0.0061 0.0051
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0039 0.0042 0.0151
Echinococcus granulosus protein kinase shaggy 0.1407 0.2738 0.4901
Schistosoma mansoni hypothetical protein 0.0023 0.001 0.0017
Echinococcus granulosus caspase 3 0.0073 0.0109 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.009 0.0266
Trichomonas vaginalis esterase, putative 0.0074 0.0111 0.0341
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.0684 0.2498
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0063 0.009 0.0328
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0113 0.0189 0.0188
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0027 0.0096
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0419 0.0792 0.2882
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0025 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.009 0.0264
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0111 0.1034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0025 0.0043
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0064 0.0232
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0063 0.009 0.0328
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0028 0.002 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0189 0.0628
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0123 0.0207 0.0755
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0042 0.0088
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0275 0.0507 0.1852
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0028 0.002 0.0036
Schistosoma mansoni microtubule-associated protein tau 0.2852 0.5586 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0028 0.002 0.0073
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.0004 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0025 0.0043
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0123 0.0207 0.0755
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0053 0.0052
Trypanosoma brucei polo-like protein kinase 0.0113 0.0189 0.0687
Entamoeba histolytica hypothetical protein 0.0028 0.002 0.0073
Entamoeba histolytica hypothetical protein 0.0186 0.0332 0.1212
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0028 0.002 0.0036
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0028 0.002 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0111 0.0402
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0201 0.0361 0.0361
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0028 0.002 0.0073
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0079 0.0141
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0188 0.0336 0.1214
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0039 0.8186
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1407 0.2738 0.2738
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.0094 0.0168
Trypanosoma brucei metacaspase 5, putative 0.0027 0.0018 0.0063
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0085 0.0151
Brugia malayi jmjC domain containing protein 0.002 0.0004 0.0006
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0028 0.0049
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0215 0.5932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0028 0.002 0.0073
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0028 0.002 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0028 0.002 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0042 0.0151
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0042 0.0088
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.0456 0.1651
Entamoeba histolytica protein kinase, putative 0.1407 0.2738 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Schistosoma mansoni netrin receptor unc5 0.0032 0.0028 0.0049
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0035 0.0169
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.002 0.0058
Loa Loa (eye worm) hypothetical protein 0.0158 0.0276 0.0994
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0189 0.0628
Echinococcus granulosus neuropeptide receptor A26 0.0934 0.1806 0.3233
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0478 0.0908 0.3305
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0111 0.1034
Plasmodium falciparum metacaspase-like protein 0.0027 0.0018 0.0063
Schistosoma mansoni cpg binding protein 0.003 0.0025 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0027 0.0032
Mycobacterium ulcerans hypothetical protein 0.0074 0.0111 0.2645
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.0257 0.046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0111 0.0197
Entamoeba histolytica hypothetical protein 0.0186 0.0332 0.1212
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0025 0.0034
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.0136 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0027 0.0032
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0094 0.0131
Loa Loa (eye worm) acetyltransferase 0.0152 0.0266 0.0956
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0092 0.0148 0.0477
Plasmodium falciparum sentrin-specific protease 1 0.0039 0.0042 0.0151
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.002 0.0058
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0149 0.026 0.0947
Loa Loa (eye worm) hypothetical protein 0.0074 0.0111 0.0389
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0275 0.0507 0.1852
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0025 0.0024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0023 0.0041
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.084 0.1622 0.2256
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0018 0.0063
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0019 0.0068
Toxoplasma gondii ATPase, AAA family protein 0.0031 0.0027 0.0096
Onchocerca volvulus Huntingtin homolog 0.0255 0.0469 0.0464
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.009 0.0328
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0085 0.0151
Brugia malayi Plexin repeat family protein 0.0039 0.0042 0.0058
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.0266 0.0475
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0039 0.0042 0.0074
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0149 0.026 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0031 0.0027 0.0047
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0064 0.1179
Schistosoma mansoni tyrosine kinase 0.0159 0.0278 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Brugia malayi beta-lactamase family protein 0.0074 0.0111 0.0154
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1407 0.2738 0.4901
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.002 0.0058
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0028 0.002 0.0073
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0018 0.0063
Loa Loa (eye worm) hypothetical protein 0.0255 0.0469 0.1699
Echinococcus multilocularis caspase 3 0.0073 0.0109 0.0109
Leishmania major phosphatidylinositol kinase, putative 0.0028 0.002 0.0073
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.0004 0.0014
Schistosoma mansoni hypothetical protein 0.0108 0.0178 0.0317
Schistosoma mansoni hypothetical protein 0.0084 0.013 0.0232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0053 0.0094
Echinococcus granulosus replication factor c subunit 1 0.0031 0.0027 0.0047
Loa Loa (eye worm) hypothetical protein 0.0508 0.0967 0.3523
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0092 0.0148 0.0477
Echinococcus granulosus dnaJ subfamily B 0.041 0.0774 0.1385
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0005 0.0016
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0123 0.0207 0.0696
Entamoeba histolytica protein kinase domain containing protein 0.1407 0.2738 1
Onchocerca volvulus 0.0028 0.002 0.001
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.0433 0.0774
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0149 0.026 0.0947
Brugia malayi RNA recognition motif domain containing protein 0.0188 0.0336 0.0468
Trypanosoma brucei protein kinase, putative 0.1407 0.2738 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0455 0.0861 0.3095
Leishmania major phosphatidylinositol 4-kinase, putative 0.0028 0.002 0.0073
Giardia lamblia Telomerase catalytic subunit 0.1377 0.2679 0.9783
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0086 0.0313
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.002 0.0028
Loa Loa (eye worm) hypothetical protein 0.0074 0.0111 0.0389
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0042 0.0151
Brugia malayi Thioredoxin reductase 0.0046 0.0056 0.0078
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0028 0.0027
Giardia lamblia Kinase, PLK 0.0113 0.0189 0.0619
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.009 0.0161
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.0018 0.0025
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0028 0.002 0.0058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0035 0.0169
Echinococcus multilocularis cpg binding protein 0.003 0.0025 0.0025
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0123 0.0207 0.037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0115 0.0205
Brugia malayi intracellular kinase 0.1407 0.2738 0.381
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0064 0.0232
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0031 0.0027 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0255 0.0469 0.1699
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0123 0.0207 0.0755
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0025 0.0034
Trypanosoma brucei Metacaspase-4 0.0027 0.0018 0.0063
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0111 0.1034
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0205 0.0369 0.0661
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0085 0.0151
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0111 0.1034
Onchocerca volvulus 0.0031 0.0027 0.0017
Brugia malayi jmjC domain containing protein 0.0201 0.0361 0.0503
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0306 0.1114
Mycobacterium leprae Probable lipase LipE 0.0074 0.0111 0.4331
Loa Loa (eye worm) hypothetical protein 0.0105 0.0173 0.0616
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0065 0.0094 0.0343
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0127
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.084 0.1622 0.5896
Leishmania major trypanothione reductase 0.0046 0.0056 0.0203
Loa Loa (eye worm) hypothetical protein 0.0202 0.0363 0.1313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0025 0.0074
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0042 0.0058
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0025 0.0043
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0111 0.0341
Echinococcus multilocularis Protein lozenge 0.006 0.0084 0.0083
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0174 0.0308 0.1125
Plasmodium vivax telomerase reverse transcriptase, putative 0.1377 0.2679 0.9785
Loa Loa (eye worm) hypothetical protein 0.0479 0.091 0.3313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.002 0.0058
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0247 0.0452 0.1651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0054 0.0095
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0064 0.2099
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0019 0.0068
Loa Loa (eye worm) hypothetical protein 0.0074 0.0111 0.0389
Giardia lamblia Sentrin specific protease, putative 0.0039 0.0042 0.0079
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0025 0.0043
Echinococcus granulosus caspase 2 0.0027 0.0018 0.0031
Trichomonas vaginalis replication factor C large subunit, putative 0.0031 0.0027 0.0033
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0028 0.002 0.0073
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0025 0.0034
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0028 0.002 0.0073
Brugia malayi TAR-binding protein 0.0188 0.0336 0.0468
Loa Loa (eye worm) intermediate filament protein 0.0028 0.002 0.0058
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0028 0.002 0.0073
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0174 0.0308 0.0551
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0027 0.0032
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0025 0.0043
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0074
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.0215 0.0214
Mycobacterium tuberculosis Conserved protein 0.0074 0.0111 0.1034
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0028 0.002 0.0073
Echinococcus granulosus peregrin 0.0065 0.0094 0.0167
Trichomonas vaginalis set domain proteins, putative 0.0477 0.0906 0.3266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0356 0.0667 0.2436
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0178 0.0247
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.084 0.1622 0.5896
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0085 0.0085
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0123 0.0207 0.0742
Brugia malayi MH2 domain containing protein 0.0249 0.0456 0.0634
Loa Loa (eye worm) TK/EGFR protein kinase 0.0294 0.0544 0.1974
Schistosoma mansoni plexin 0.0039 0.0042 0.0074
Onchocerca volvulus Huntingtin homolog 0.0255 0.0469 0.0464
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0039 0.0042 0.0151
Echinococcus multilocularis caspase 2 0.0027 0.0018 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0336 0.0601
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0025 0.0074
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0028 0.0039
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0042 0.0088
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0607 0.1161 0.4204
Schistosoma mansoni transcription factor LCR-F1 0.0186 0.0332 0.0594
Onchocerca volvulus Cell death protein 3 homolog 0.0027 0.0018 0.0008
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0066 0.0241
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0004 0.0007
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0064 0.1179
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0063 0.009 0.0328
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.002 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0136 0.0435
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0028 0.002 0.0073
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0028 0.002 0.0036
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.084 0.1622 0.5896
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0054 0.018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0049
Schistosoma mansoni intermediate filament proteins 0.0028 0.002 0.0035
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0004 0.0007
Echinococcus granulosus Niemann Pick C1 protein 0.0202 0.0363 0.0649
Onchocerca volvulus 0.0028 0.002 0.001
Schistosoma mansoni lamin 0.0028 0.002 0.0035
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0046 0.0096
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0028 0.0086
Echinococcus multilocularis expressed conserved protein 0.0135 0.0232 0.0231
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0074
Giardia lamblia Kinase, CMGC MAPK 0.0063 0.009 0.0257
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0028 0.002 0.0073
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.009 0.0266
Mycobacterium ulcerans lipase LipD 0.0074 0.0111 0.2645
Schistosoma mansoni lamin 0.0028 0.002 0.0035
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.0136 0.0243
Schistosoma mansoni hypothetical protein 0.005 0.0064 0.0113
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0039 0.0042 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0336 0.0601
Echinococcus multilocularis tar DNA binding protein 0.0188 0.0336 0.0336
Echinococcus multilocularis epidermal growth factor receptor 0.0159 0.0278 0.0278
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0004 0.0014
Echinococcus multilocularis sentrin specific protease 1 0.0039 0.0042 0.0041
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0159 0.0278 0.0497
Onchocerca volvulus 0.0479 0.091 0.091
Leishmania major telomerase reverse transcriptase, putative 0.1377 0.2679 0.9785
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0025 0.0034
Schistosoma mansoni tyrosine kinase 0.0155 0.0271 0.0484
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0127
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0149 0.026 0.7341
Echinococcus multilocularis protein kinase shaggy 0.1407 0.2738 0.2738
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.01 0.0162 0.0289
Brugia malayi jmjC domain containing protein 0.002 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Loa Loa (eye worm) phosphatidylinositol kinase 0.0028 0.002 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0025 0.0034
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0031 0.0027 0.0096
Echinococcus granulosus Ankyrin 0.0032 0.0028 0.005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0053 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0027 0.0032
Schistosoma mansoni hypothetical protein 0.0048 0.0061 0.0108
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0028 0.002 0.002
Brugia malayi AF-10 protein 0.002 0.0005 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0074
Loa Loa (eye worm) TAR-binding protein 0.0188 0.0336 0.1214
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0086 0.0313
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0196 0.2008
Echinococcus multilocularis Ankyrin 0.0032 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Brugia malayi beta-lactamase 0.0074 0.0111 0.0154
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.0266 0.037
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0087 0.0136 0.0189
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0008 0.0014
Brugia malayi serine/threonine-protein kinase plk-2 0.0113 0.0189 0.0262
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0064 0.2099
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0028 0.002 0.0073
Echinococcus granulosus Protein patched homolog 1 0.0087 0.0136 0.0243
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0028 0.002 0.0073
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0039 0.0042 0.0151
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0025 0.0043
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0054 0.0194
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0094 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.002 0.0028
Schistosoma mansoni nuclear hormone receptor 0.003 0.0025 0.0043
Loa Loa (eye worm) hypothetical protein 0.005 0.0064 0.0218
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0028 0.002 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0027 0.0096
Echinococcus multilocularis protein patched 0.0087 0.0136 0.0136
Giardia lamblia Kinase, CMGC GSK 0.1407 0.2738 1
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0111 0.1034
Plasmodium vivax replication factor C subunit 1, putative 0.0031 0.0027 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0056 0.0189
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0025 0.0024
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0028 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Echinococcus granulosus caspase 0.01 0.0162 0.0289
Echinococcus multilocularis GPCR, family 2 0.005 0.0064 0.0063
Schistosoma mansoni topbp1 0.0031 0.0027 0.0047
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0056 0.0056
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0215 0.0384
Echinococcus multilocularis caspase 8 0.0027 0.0018 0.0017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0149 0.026 0.0947
Loa Loa (eye worm) hypothetical protein 0.005 0.0064 0.0217
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0018 0.0049
Schistosoma mansoni tyrosine kinase 0.0155 0.0271 0.0484
Trypanosoma brucei metacaspase 0.0027 0.0018 0.0063
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0111 0.2645
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0056 0.0411
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0215 0.0384
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0134 0.0229 0.2388
Plasmodium vivax hypothetical protein, conserved 0.0028 0.002 0.0058
Brugia malayi hypothetical protein 0.0186 0.0332 0.0462
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.009 0.0266
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0508 0.0967 0.1731
Mycobacterium tuberculosis Conserved protein 0.0074 0.0111 0.1034
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0508 0.0967 0.0967
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0123 0.0207 0.0755
Brugia malayi intermediate filament protein 0.0028 0.002 0.0028
Echinococcus multilocularis nibrin 0.0031 0.0027 0.0026
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0028 0.002 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Echinococcus granulosus intermediate filament protein 0.0028 0.002 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0025 0.0034
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0028 0.002 0.002
Loa Loa (eye worm) RNA binding protein 0.0188 0.0336 0.1214
Onchocerca volvulus 0.1407 0.2738 0.2758
Echinococcus multilocularis lamin dm0 0.0028 0.002 0.002
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.0266 0.0265
Mycobacterium ulcerans hypothetical protein 0.005 0.0064 0.1179
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0028 0.002 0.0073
Giardia lamblia Kinase, CMGC GSK 0.1407 0.2738 1
Schistosoma mansoni lozenge 0.006 0.0084 0.0149
Brugia malayi RNA binding protein 0.0188 0.0336 0.0468
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.0215 0.0384
Brugia malayi topoisomerase 0.0031 0.0027 0.0037
Schistosoma mansoni hypothetical protein 0.0061 0.0086 0.0154
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.009 0.0328
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.0004 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0019 0.0068
Schistosoma mansoni protein phosphatase 2C 0.002 0.0004 0.0007
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0039 0.0042 1
Brugia malayi AMP-binding enzyme family protein 0.005 0.0064 0.0089
Onchocerca volvulus 0.0074 0.0111 0.0102
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.0684 0.2498
Brugia malayi nuclear receptor NHR-88 0.003 0.0025 0.0034
Brugia malayi Pre-SET motif family protein 0.0419 0.0792 0.1102
Echinococcus multilocularis Niemann Pick C1 protein 0.0202 0.0363 0.0363
Echinococcus multilocularis phd:f box containing protein 0.002 0.0004 0.0004
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0123 0.0207 0.0207
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0064 0.0501
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0064 0.0232
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0065 0.0094 0.0847
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0196 0.2008
Plasmodium falciparum telomerase reverse transcriptase 0.1377 0.2679 0.9785
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0028 0.002 0.0036
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0123 0.0207 0.0755
Brugia malayi hypothetical protein 0.0031 0.0027 0.0037
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0027 0.0033
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0092 0.0148 0.0264
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0082
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.5041 0.9901 1
Brugia malayi Uncoordinated protein 44 0.0032 0.0028 0.0039
Trypanosoma brucei metacaspase MCA2 0.0027 0.0018 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0053 0.0052
Schistosoma mansoni fkbp-rapamycin associated protein 0.0028 0.002 0.0036
Leishmania major phosphatidylinositol kinase related protein, putative 0.0028 0.002 0.0073
Plasmodium falciparum phd finger protein, putative 0.0061 0.0086 0.0313
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0028 0.002 0.0073
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1377 0.2679 0.9785
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0028 0.002 0.0073
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0028 0.0027
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.018 0.032 0.1104
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0149 0.026 0.0889
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.002 0.0073
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0085 0.0307
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0064 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0082
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0028 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0025 0.0034
Brugia malayi MAP kinase sur-1 0.0063 0.009 0.0125
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.002 0.0058
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0812 0.1567 0.5721
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.009 0.0264
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0063 0.009 0.0328
Brugia malayi Furin-like cysteine rich region family protein 0.0294 0.0544 0.0757
Onchocerca volvulus 0.0477 0.0906 0.0906
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0025 0.0034
Leishmania major phosphatidylinositol 3-kinase, putative 0.0123 0.0207 0.0755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.0018 0.0031
Trypanosoma cruzi polo-like protein kinase, putative 0.0113 0.0189 0.0687
Brugia malayi jmjC domain containing protein 0.002 0.0004 0.0006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0039 0.0215
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0111 0.0341
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0025 0.0024
Trypanosoma cruzi polo-like protein kinase, putative 0.0113 0.0189 0.0687
Loa Loa (eye worm) jmjC domain-containing protein 0.0127 0.0215 0.0771
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0042 0.0058
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.0086
Echinococcus granulosus lysine specific demethylase 5A 0.0076 0.0115 0.0205
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0111 0.0389
Schistosoma mansoni tyrosine kinase 0.0159 0.0278 0.0497
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.0215 0.0783
Schistosoma mansoni patched 1 0.0087 0.0136 0.0243
Echinococcus multilocularis musashi 0.0028 0.002 0.002
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1407 0.2738 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0172 0.1744
Schistosoma mansoni jumonji domain containing protein 0.002 0.0004 0.0007
Echinococcus multilocularis nuclear factor of activated T cells 5 0.031 0.0577 0.0576
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0028 0.002 0.0036
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.0215 0.2229
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.0276 0.0994
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0039 0.0042 0.0151
Loa Loa (eye worm) hypothetical protein 0.0106 0.0174 0.0622
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0688 0.1322 0.4826
Loa Loa (eye worm) hypothetical protein 0.0074 0.0111 0.0389
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0025 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0082
Toxoplasma gondii RNA-directed DNA polymerase 0.1377 0.2679 0.9785
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1377 0.2679 0.9785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0336 0.0601
Schistosoma mansoni survival motor neuron protein 0.0048 0.0061 0.0108
Brugia malayi AMP-binding enzyme family protein 0.005 0.0064 0.0089
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0123 0.0207 0.0755
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0025 0.0034
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0028 0.0049
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0064 0.1179
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0123 0.0207 0.0755
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0064 0.0232
Trypanosoma cruzi metacaspase, putative 0.0027 0.0018 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Plasmodium vivax sentrin-specific protease 2, putative 0.0039 0.0042 0.0137
Brugia malayi hypothetical protein 0.0479 0.091 0.1266
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0028 0.002 0.0073
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0025 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0189 0.0628
Plasmodium vivax sentrin-specific protease 1, putative 0.0039 0.0042 0.0137
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0111 0.4331
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0046 0.0168
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0186 0.0332 0.0332
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0092 0.0148 0.0477
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0064 0.0501
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0025 0.0043
Trypanosoma cruzi metacaspase, putative 0.0027 0.0018 0.0063
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Echinococcus granulosus GPCR family 2 0.005 0.0064 0.0113
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0066 0.0241
Loa Loa (eye worm) hypothetical protein 0.0087 0.0136 0.0482
Schistosoma mansoni tyrosine kinase 0.0294 0.0544 0.0973
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0508 0.0967 0.1346
Loa Loa (eye worm) hypothetical protein 0.0237 0.0433 0.1567
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0025 0.0074
Brugia malayi jmjC domain containing protein 0.0076 0.0115 0.016
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0113 0.0189 0.0337
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0082
Loa Loa (eye worm) inositol-1 0.0149 0.026 0.0934
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0196 0.2008
Brugia malayi ecdysteroid receptor 0.003 0.0025 0.0034
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0306 0.1114
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0111 0.0389
Trypanosoma cruzi metacaspase, putative 0.0027 0.0018 0.0063
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0028 0.002 0.0073
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0054 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Brugia malayi Protein kinase domain containing protein 0.0046 0.0056 0.0078
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0054 0.0132
Trichomonas vaginalis CMGC family protein kinase 0.1407 0.2738 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0063 0.009 0.0161
Schistosoma mansoni hypothetical protein 0.041 0.0774 0.1385
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0094 0.2131
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0111 0.0341
Mycobacterium tuberculosis Probable reductase 0.0105 0.0172 0.1744
Schistosoma mansoni hypothetical protein 0.005 0.0064 0.0113
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0085 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Schistosoma mansoni hypothetical protein 0.0084 0.013 0.0232
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0074
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0008 0.0013
Brugia malayi Cell death protein 3 precursor 0.0027 0.0018 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0111 0.0341
Brugia malayi Protein kinase domain containing protein 0.0095 0.0153 0.0213
Echinococcus multilocularis jumonji domain containing protein 0.0085 0.0134 0.0133
Loa Loa (eye worm) hypothetical protein 0.0479 0.091 0.3313
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0115 0.0404
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1407 0.2738 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0113 0.0189 0.0687
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0025 0.0034
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0149 0.026 0.0947
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0039 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0085 0.0151
Entamoeba histolytica hypothetical protein 0.0688 0.1322 0.4826
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0275 0.0507 0.18
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0028 0.002 0.0073
Schistosoma mansoni jumonji domain containing protein 0.016 0.028 0.0501
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0074
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0111 0.0197
Echinococcus multilocularis Zinc finger, PHD finger 0.0123 0.0207 0.0207
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1407 0.2738 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.084 0.1622 0.5922
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0275 0.0507 0.0706
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0028 0.002 0.002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0028 0.002 0.0073
Echinococcus multilocularis sentrin specific protease 8 0.0092 0.0148 0.0147
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0064 0.1179
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.1407 0.2738 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0275 0.0507 0.1852
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0025 0.0024
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0027 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0113 0.0189 0.0674
Echinococcus granulosus PHD finger protein rhinoceros 0.0061 0.0086 0.0154
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0094 0.2131
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.002 0.0058
Echinococcus multilocularis epidermal growth factor receptor 0.0294 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0108 0.0178 0.0634
Echinococcus multilocularis insulin receptor 0.0095 0.0153 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0123 0.0207 0.037
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0005 0.0016
Echinococcus multilocularis dnaJ subfamily B 0.041 0.0774 0.0774
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.002 0.0073
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0018 0.0063
Echinococcus granulosus cpg binding protein 0.003 0.0025 0.0045
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0004 0.0004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0149 0.026 0.0889
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0172 0.1744
Brugia malayi PHD-finger family protein 0.0022 0.0008 0.0011
Echinococcus granulosus caspase 8 0.0027 0.0018 0.0031
Brugia malayi PHD-finger family protein 0.0061 0.0086 0.012
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0074
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0123 0.0207 0.0755
Echinococcus multilocularis mitogen activated protein kinase 0.0063 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0127
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0028 0.002 0.0036
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0046 0.0168
Loa Loa (eye worm) hypothetical protein 0.0074 0.0111 0.0389
Echinococcus granulosus mitogen activated protein kinase 0.0063 0.009 0.0161
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0196 0.8411
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0008 0.0029
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.0684 0.2498
Toxoplasma gondii ABC1 family protein 0.0074 0.0111 0.0402
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0028 0.002 0.0073
Toxoplasma gondii histone lysine demethylase JMJD6a 0.002 0.0004 0.0014
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0064 0.0232
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.01 0.0162 0.0161
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0275 0.0507 0.1852
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0042 0.0088
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.002 0.0028
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0025 0.0043
Schistosoma mansoni tyrosine kinase 0.0095 0.0153 0.0273
Leishmania major hypothetical protein, conserved 0.002 0.0004 0.0014
Schistosoma mansoni hypothetical protein 0.005 0.0064 0.0113
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0127
Echinococcus granulosus nibrin 0.0031 0.0027 0.0047
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1407 0.2738 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0063 0.009 0.0314
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0018 0.0063
Echinococcus multilocularis lamin 0.0028 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.005 0.0064 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Mycobacterium tuberculosis Conserved protein 0.0074 0.0111 0.1034
Schistosoma mansoni hypothetical protein 0.0186 0.0332 0.0594
Brugia malayi Bromodomain containing protein 0.0065 0.0094 0.013
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0028 0.002 0.0036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0064 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0014
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0039 0.0042 0.0088
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0064 0.0217
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0004 0.0014
Mycobacterium ulcerans beta-lactamase 0.0074 0.0111 0.2645
Schistosoma mansoni hypothetical protein 0.0028 0.002 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0025 0.0034
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0019 0.0068
Entamoeba histolytica hypothetical protein 0.0028 0.002 0.0073
Onchocerca volvulus 0.0039 0.0042 0.0032
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0025 0.0024
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0025 0.0043
Plasmodium falciparum glycogen synthase kinase 3 0.1407 0.2738 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.0087
Echinococcus granulosus sentrin specific protease 7 0.0174 0.0308 0.0551
Leishmania major hypothetical protein, conserved 0.0028 0.002 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0053 0.0094
Trypanosoma brucei telomerase reverse transcriptase 0.1377 0.2679 0.9785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0035 0.0169
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0111 0.0402
Brugia malayi Death domain containing protein 0.0032 0.0028 0.0039
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0111 0.1034
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0111 0.2645
Leishmania major hypothetical protein, unknown function 0.0028 0.002 0.0073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0085 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0082
Brugia malayi hypothetical protein 0.0027 0.0019 0.0027
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0111 0.011
Echinococcus multilocularis plexin a4 0.0046 0.0056 0.0056
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0025 0.0074
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0039 0.0392
Schistosoma mansoni thyroid hormone receptor 0.003 0.0025 0.0043
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0039 0.0042 0.0151
Toxoplasma gondii target of rapamycin (TOR), putative 0.0028 0.002 0.0073
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.0684 0.2498
Toxoplasma gondii FATC domain-containing protein 0.0028 0.002 0.0073
Echinococcus multilocularis peregrin 0.0065 0.0094 0.0093
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.0276 0.0384
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0189 0.0337
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0019 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0111 0.0402
Schistosoma mansoni coup transcription factor 0.003 0.0025 0.0043
Onchocerca volvulus 0.0074 0.0111 0.0102
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0039 0.0042 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0035 0.0169
Echinococcus multilocularis Niemann Pick C1 protein 0.0288 0.0534 0.0534
Echinococcus granulosus nuclear factor of activated T cells 5 0.031 0.0577 0.1032
Trichomonas vaginalis inositol monophosphatase, putative 0.0149 0.026 0.0889
Schistosoma mansoni hypothetical protein 0.0084 0.013 0.0232
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0004 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Echinococcus multilocularis neuropeptide s receptor 0.0934 0.1806 0.1806
Leishmania major phosphatidylinositol 3-kinase, putative 0.0028 0.002 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0085 0.0151
Schistosoma mansoni DNA ligase IV 0.0031 0.0027 0.0047
Onchocerca volvulus 0.0029 0.0022 0.0012
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0149 0.026 0.0947
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0042 0.0151
Onchocerca volvulus Alhambra homolog 0.0061 0.0086 0.0077
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0028 0.002 0.0036
Trichomonas vaginalis Sentrin-specific protease, putative 0.0092 0.0148 0.0477
Brugia malayi AMP-binding enzyme family protein 0.005 0.0064 0.0089
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0004 0.0007
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0028 0.002 0.0073
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0005 0.0016
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0028 0.002 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0025 0.0074
Echinococcus granulosus phd:f box containing protein 0.002 0.0004 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.084 0.1622 0.5922
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0123 0.0207 0.0742
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0027 0.0032
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0123 0.0207 0.0755
Echinococcus granulosus serine protein kinase ATM 0.0028 0.002 0.0036
Brugia malayi glutathione reductase 0.0046 0.0056 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0054
Schistosoma mansoni inositol monophosphatase 0.0149 0.026 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0028 0.002 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0188 0.0336 0.0601
Schistosoma mansoni phd/f-box containing protein 0.002 0.0004 0.0007
Onchocerca volvulus 0.005 0.0064 0.0054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0025 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0061 0.0086 0.03
Echinococcus granulosus insulin receptor 0.0095 0.0153 0.0273
Brugia malayi CXXC zinc finger family protein 0.0029 0.0022 0.0031
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0137
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.0433 0.0432
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0927 0.1792 0.3208
Echinococcus multilocularis microtubule associated protein 2 0.2852 0.5586 0.5585
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0028 0.002 0.0073
Leishmania major hypothetical protein, conserved 0.0027 0.0019 0.0068
Toxoplasma gondii hypothetical protein 0.0059 0.0081 0.0295
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0172 0.1744
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0025 0.0074
Trypanosoma cruzi FHA domain containing protein, putative 0.0031 0.0027 0.0096
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0064 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0025 0.0074
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0344 0.3707
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Echinococcus multilocularis expressed conserved protein 0.019 0.0339 0.0339
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0054 0.0194
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.002 0.0058
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0028 0.005
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0172 0.7302
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0275 0.0507 0.18
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0028 0.002 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Plasmodium vivax metacaspase 1, putative 0.0027 0.0018 0.0049
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0027 0.0096
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0275 0.0507 0.0908
Echinococcus granulosus microtubule associated protein 2 0.2852 0.5586 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0028 0.002 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0074
Leishmania major hypothetical protein, conserved 0.0074 0.0111 0.0402
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0031 0.0027 0.0304
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0607 0.1161 0.4204
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0053 0.0094
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.002 0.0028
Echinococcus granulosus expressed conserved protein 0.0135 0.0232 0.0414
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0111 0.0154
Trypanosoma brucei SUMO1/Ulp2, putative 0.0039 0.0042 0.0151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0053 0.0094
Brugia malayi DKFZp564C0469 protein 0.0031 0.0027 0.0037
Echinococcus granulosus epidermal growth factor receptor 0.0159 0.0278 0.0497
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0134 0.0229 1
Schistosoma mansoni tyrosine kinase 0.0155 0.0271 0.0484
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0201 0.0361 0.0646
Loa Loa (eye worm) hypothetical protein 0.005 0.0064 0.0218
Plasmodium falciparum metacaspase 1 0.0027 0.0018 0.0063
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0061 0.0086 0.0154
Trypanosoma cruzi target of rapamycin kinase 3 0.0028 0.002 0.0073
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1407 0.2738 0.4901
Loa Loa (eye worm) phosphatidylinositol 3 0.0247 0.0452 0.1639
Brugia malayi jmjC domain containing protein 0.002 0.0004 0.0006
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0927 0.1792 0.3208
Loa Loa (eye worm) hypothetical protein 0.0061 0.0085 0.0295
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0064 0.0232
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0088 0.0322
Echinococcus multilocularis sentrin specific protease 7 0.0174 0.0308 0.0308
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0022 0.0065
Entamoeba histolytica protein kinase domain containing protein 0.1407 0.2738 1
Entamoeba histolytica hypothetical protein 0.0028 0.002 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.002 0.0009
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0042 0.0151
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0123 0.0207 0.037
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0019 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.009 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Entamoeba histolytica hypothetical protein 0.0186 0.0332 0.1212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0053 0.0094
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0004 0.0007
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.002 0.002
Schistosoma mansoni caspase-7 (C14 family) 0.01 0.0162 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Echinococcus granulosus sentrin specific protease 8 0.0092 0.0148 0.0264
Brugia malayi Telomerase reverse transcriptase 0.3664 0.7187 1
Echinococcus multilocularis protein dispatched 1 0.0099 0.016 0.016
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0025 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0064 0.1179
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0086 0.03
Echinococcus multilocularis inositol monophosphatase 1 0.0149 0.026 0.0259
Loa Loa (eye worm) plexin A 0.0046 0.0056 0.0189
Trypanosoma brucei metacaspase MCA3 0.0027 0.0018 0.0063
Echinococcus granulosus expressed conserved protein 0.019 0.0339 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Giardia lamblia PHD finger protein 15 0.0061 0.0086 0.0243
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0189 0.0628
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0092 0.0148 0.0205
Echinococcus granulosus lamin 0.0028 0.002 0.0035
Plasmodium vivax glycogen synthase kinase 3, putative 0.1407 0.2738 1
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0064 0.1179
Brugia malayi hypothetical protein 0.0031 0.0027 0.0037
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0123 0.0207 0.0696
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.002
Brugia malayi Inositol-1 0.0149 0.026 0.0361
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0927 0.1792 0.1792
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0189 0.0628
Echinococcus granulosus sentrin specific protease 1 0.0039 0.0042 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.009 0.0161
Brugia malayi CHE-14 protein 0.0087 0.0136 0.0189
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0094 0.0168
Echinococcus multilocularis mitogen activated protein kinase 3 0.0063 0.009 0.009
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0004 0.0004
Plasmodium falciparum glutathione reductase 0.0046 0.0056 0.0203
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0031 0.0027 0.0096
Onchocerca volvulus 0.0039 0.0042 0.0032
Brugia malayi steroid hormone receptor 0.003 0.0025 0.0034
Loa Loa (eye worm) glutathione reductase 0.0046 0.0056 0.0189
Entamoeba histolytica protein kinase rad3, putative 0.0028 0.002 0.0073
Loa Loa (eye worm) runx1 0.006 0.0084 0.0291
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0039 0.0042 0.0151
Brugia malayi Niemann-Pick C1 protein precursor 0.0202 0.0363 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Echinococcus granulosus death domain containing protein 0.0032 0.0028 0.0049
Onchocerca volvulus 0.0028 0.002 0.001
Schistosoma mansoni thyroid hormone receptor 0.003 0.0025 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0025 0.0034
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0056 0.0203
Brugia malayi beta-lactamase family protein 0.0074 0.0111 0.0154
Treponema pallidum DNA ligase (lig) 0.0031 0.0027 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0025 0.0043
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0025 0.0043
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0138
Onchocerca volvulus Serine\/threonine kinase homolog 0.0113 0.0189 0.018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.002 0.0028
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0008 0.0007
Brugia malayi plexin A 0.0046 0.0056 0.0078
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Echinococcus multilocularis caspase 0.01 0.0162 0.0161
Echinococcus multilocularis replication factor c subunit 1 0.0031 0.0027 0.0026
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0028 0.002 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0064 0.0088
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0025 0.0043
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.0215 0.0783
Plasmodium vivax hypothetical protein 0.0028 0.002 0.0058
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.002 0.0073
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0028 0.002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0061 0.0084
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0149 0.026 0.0947
Trypanosoma brucei trypanothione reductase 0.0046 0.0056 0.0203
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0063 0.009 0.0328
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.002 0.0028
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0092 0.0148 0.0538
Trypanosoma cruzi hypothetical protein 0.0092 0.0148 0.0538
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0042 0.0088
Schistosoma mansoni cpg binding protein 0.0029 0.0022 0.0039
Echinococcus granulosus jumonji domain containing protein 0.0085 0.0134 0.0238
Plasmodium vivax glutathione reductase, putative 0.0046 0.0056 0.0189
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0078 0.0271
Echinococcus granulosus neuropeptide s receptor 0.0934 0.1806 0.3233
Schistosoma mansoni topbp1 0.0031 0.0027 0.0047

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 4.6109 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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