Detailed information for compound 1401455

Basic information

Technical information
  • TDR Targets ID: 1401455
  • Name: 2-(2-fluorophenyl)-5-(hydroxymethyl)-N-(pyrid in-2-ylmethyl)triazole-4-carboxamide
  • MW: 327.313 | Formula: C16H14FN5O2
  • H donors: 2 H acceptors: 5 LogP: 1.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1nn(nc1C(=O)NCc1ccccn1)c1ccccc1F
  • InChi: 1S/C16H14FN5O2/c17-12-6-1-2-7-14(12)22-20-13(10-23)15(21-22)16(24)19-9-11-5-3-4-8-18-11/h1-8,23H,9-10H2,(H,19,24)
  • InChiKey: BHAZNRYHZOMVBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-fluorophenyl)-5-(hydroxymethyl)-N-(2-pyridylmethyl)triazole-4-carboxamide
  • 2-(2-fluorophenyl)-5-(hydroxymethyl)-N-(2-pyridylmethyl)-4-triazolecarboxamide
  • 2-(2-fluorophenyl)-5-methylol-N-(2-pyridylmethyl)triazole-4-carboxamide
  • 2-(2-fluorophenyl)-5-(hydroxymethyl)-N-(pyridin-2-ylmethyl)-1,2,3-triazole-4-carboxamide
  • D217-0372
  • NCGC00117058-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ephrin receptor 0.005 0.0022 0.0019
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.009 0.0106 1
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0071 0.0065 0.0366
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0008 0.0009
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0071 0.0065 0.0078
Loa Loa (eye worm) hypothetical protein 0.0138 0.0208 0.0208
Trichomonas vaginalis centaurin beta, putative 0.0071 0.0065 0.035
Entamoeba histolytica protein kinase domain containing protein 0.0077 0.0079 0.0464
Loa Loa (eye worm) AUR protein kinase 0.0077 0.0079 0.0079
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0065 0.0374
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0012 0.0014
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0045 0.0012 0.0014
Trypanosoma cruzi hypothetical protein 0.0071 0.0065 0.5718
Echinococcus granulosus ephrin type A receptor 4 A 0.0045 0.0012 0.0014
Brugia malayi Regulator of G protein signaling domain containing protein 0.0769 0.1551 0.1551
Leishmania major protein kinase, putative 0.0064 0.0052 0.4282
Trichomonas vaginalis hypothetical protein 0.0071 0.0065 0.035
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Schistosoma mansoni regulator of G protein signaling 0.0769 0.1551 0.1548
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0043 0.0043
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Onchocerca volvulus outspread protein homolog 0.0071 0.0065 0.0366
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Leishmania major protein kinase, putative 0.009 0.0106 1
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0236 0.0416 0.0416
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0071 0.0065 0.0065
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0012 0.0014
Brugia malayi Dynamin 0.0071 0.0065 0.0065
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0071 0.0065 0.5718
Trypanosoma brucei protein kinase, putative 0.0064 0.0052 0.4282
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0071 0.0065 0.0065
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0079 0.044
Entamoeba histolytica serine/threonine kinase, putative 0.0045 0.0012 0.0025
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Leishmania major serine/threonine-protein kinase a, putative 0.009 0.0106 1
Schistosoma mansoni growth factor receptor-bound protein 0.0071 0.0065 0.0063
Entamoeba histolytica protein kinase domain containing protein 0.0183 0.0304 0.1921
Entamoeba histolytica receptor protein kinase, putative 0.0045 0.0012 0.0025
Onchocerca volvulus Protein melted homolog 0.0071 0.0065 0.0366
Echinococcus granulosus kinase suppressor of Ras 1 0.0045 0.0012 0.0014
Trypanosoma brucei aurora B kinase 0.0077 0.0079 0.719
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Brugia malayi hypothetical protein 0.0043 0.0008 0.0008
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Echinococcus granulosus tyrosine protein kinase shark 0.0045 0.0012 0.0014
Schistosoma mansoni myotubularin-related protein 0.0071 0.0065 0.0063
Plasmodium falciparum PH domain-containing protein, putative 0.0071 0.0065 0.5718
Loa Loa (eye worm) hypothetical protein 0.0769 0.1551 0.1551
Brugia malayi serine/threonine-protein kinase 6 0.0077 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Schistosoma mansoni dynamin 0.0071 0.0065 0.0063
Brugia malayi Immunoglobulin I-set domain containing protein 0.0069 0.0061 0.0061
Echinococcus granulosus Regulator of G protein signaling 20 0.0769 0.1551 0.1854
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Echinococcus multilocularis protein kinase 0.0045 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Trichomonas vaginalis centaurin alpha, putative 0.0071 0.0065 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Schistosoma mansoni serine/threonine protein kinase 0.3638 0.7645 0.7645
Schistosoma mansoni plexin 0.0739 0.1485 0.1483
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0071 0.0065 0.0063
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0065 0.0374
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0012 0.0014
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0012 0.0014
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0045 0.0012 0.0014
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Schistosoma mansoni axis inhibition protein axin 0.0769 0.1551 0.1548
Echinococcus granulosus fibroblast growth factor receptor 4 0.0045 0.0012 0.0014
Brugia malayi Oxysterol-binding protein 0.0071 0.0065 0.0065
Echinococcus multilocularis tyrosine kinase 0.0045 0.0012 0.0014
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Echinococcus multilocularis protein KINase family member (kin 25) 0.0045 0.0012 0.0014
Entamoeba histolytica ARF GTPase activating protein, putative 0.0071 0.0065 0.0374
Echinococcus multilocularis DCC interacting protein 13 beta 0.0071 0.0065 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0208 0.1276
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Echinococcus multilocularis beta adrenergic receptor kinase 0.3638 0.7645 0.914
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0077 0.0079 0.719
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0045 0.0012 0.0014
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0045 0.0012 0.0014
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0071 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0138 0.0208 0.0208
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0109 0.0147 0.0147
Echinococcus granulosus axis inhibition protein axin 0.0769 0.1551 0.1854
Echinococcus multilocularis pdz domain containing protein 0.0071 0.0065 0.0078
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Loa Loa (eye worm) RGC/RGC protein kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Giardia lamblia Aurora kinase 0.0077 0.0079 1
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Echinococcus granulosus protein kinase 0.0045 0.0012 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0079 0.044
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0071 0.0065 0.035
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.009 0.0106 0.0612
Trypanosoma cruzi Protein kinase B 0.009 0.0106 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0045 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase ABL1 0.0045 0.0012 0.0014
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0045 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.3638 0.7645 0.7645
Brugia malayi SH2 domain containing protein 0.0045 0.0012 0.0012
Brugia malayi PH domain containing protein 0.0071 0.0065 0.0065
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0064 0.0052 0.0062
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0071 0.0065 0.0374
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0045 0.0012 0.0014
Onchocerca volvulus 0.0314 0.0583 0.3877
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Echinococcus multilocularis rac serine:threonine kinase 0.009 0.0106 0.0126
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0045 0.0012 0.0014
Echinococcus granulosus DCC interacting protein 13 beta 0.0071 0.0065 0.0078
Echinococcus multilocularis heat shock protein 70 0.0045 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Schistosoma mansoni oxysterol-binding protein 1 0.0071 0.0065 0.0063
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Entamoeba histolytica protein kinase, putative 0.009 0.0106 0.0635
Brugia malayi PH domain containing protein 0.0071 0.0065 0.0065
Loa Loa (eye worm) TK/ACK protein kinase 0.0045 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0208 0.1276
Echinococcus multilocularis exocyst complex component 2 0.0138 0.0208 0.0249
Schistosoma mansoni protein kinase 0.0045 0.0012 0.0009
Brugia malayi PH domain containing protein 0.0071 0.0065 0.0065
Loa Loa (eye worm) plexin A 0.0876 0.1778 0.1778
Brugia malayi A-kinase anchor protein 10, precursor 0.0769 0.1551 0.1551
Echinococcus granulosus cytohesin 1 0.0071 0.0065 0.0078
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0522 0.0624
Echinococcus granulosus Immunoglobulin 0.0064 0.0051 0.0061
Entamoeba histolytica serine/threonine kinase, putative 0.0045 0.0012 0.0025
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0012 0.0014
Plasmodium falciparum oxysterol-binding protein, putative 0.0071 0.0065 0.5718
Echinococcus granulosus receptor type guanylyl cyclase 0.0045 0.0012 0.0014
Brugia malayi hypothetical protein 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0138 0.0208 0.0208
Brugia malayi hypothetical protein 0.0071 0.0065 0.0065
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Echinococcus multilocularis tyrosine protein kinase HCK 0.0045 0.0012 0.0014
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0045 0.0012 0.0014
Trichomonas vaginalis centaurin/arf, putative 0.0071 0.0065 0.035
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.009 0.0106 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0039 0.0039
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0071 0.0065 0.5718
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Echinococcus granulosus axis inhibition protein axin 0.0769 0.1551 0.1854
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0064 0.0051 0.0048
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Loa Loa (eye worm) syntrophin-1 0.0071 0.0065 0.0065
Echinococcus multilocularis Regulator of G protein signaling 20 0.0769 0.1551 0.1854
Entamoeba histolytica protein kinase, putative 0.009 0.0106 0.0635
Brugia malayi Furin-like cysteine rich region family protein 0.0045 0.0012 0.0012
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Schistosoma mansoni regulator of G protein signaling 0.0769 0.1551 0.1548
Brugia malayi Protein kinase domain containing protein 0.0313 0.0581 0.0581
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0045 0.0012 0.0014
Echinococcus multilocularis regulator of G protein signaling 7 0.0769 0.1551 0.1854
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0769 0.1551 0.1551
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0314 0.0583 0.058
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Loa Loa (eye worm) TK/EPH protein kinase 0.0045 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0769 0.1551 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0045 0.0012 0.0012
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0045 0.0012 0.0009
Loa Loa (eye worm) TK/ABL protein kinase 0.0045 0.0012 0.0012
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Echinococcus multilocularis raf serine:threonine protein kinase 0.0045 0.0012 0.0014
Brugia malayi DNA-binding protein LAG-1 0.0138 0.0208 0.0208
Schistosoma mansoni vesicular amine transporter 0.0066 0.0057 0.0054
Loa Loa (eye worm) PXA domain-containing protein 0.0769 0.1551 0.1551
Entamoeba histolytica ankyrin repeat protein 0.0045 0.0012 0.0025
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Schistosoma mansoni hypothetical protein 0.0071 0.0065 0.0063
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0071 0.0065 0.0374
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0045 0.0012 0.0014
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0106 0.0635
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0045 0.0012 0.0014
Loa Loa (eye worm) serine/threonine protein kinase 0.0045 0.0012 0.0012
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.3976 0.8365 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0064 0.0052 0.4282
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3976 0.8365 0.8365
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Echinococcus multilocularis transfer RNA-Thr 0.0045 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Leishmania major protein kinase, putative 0.0077 0.0079 0.719
Loa Loa (eye worm) TK protein kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0045 0.0012 0.0014
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.009 0.0106 1
Echinococcus multilocularis epidermal growth factor receptor 0.0045 0.0012 0.0014
Echinococcus multilocularis beta 1 syntrophin 0.0071 0.0065 0.0078
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0045 0.0012 0.0009
Entamoeba histolytica tyrosin kinase, putative 0.0045 0.0012 0.0025
Echinococcus multilocularis receptor type guanylyl cyclase 0.0045 0.0012 0.0014
Onchocerca volvulus 0.0071 0.0065 0.0366
Brugia malayi probable spectrin beta chain 0.0071 0.0065 0.0065
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0077 0.0079 0.0464
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Trypanosoma cruzi rac serine-threonine kinase, putative 0.009 0.0106 1
Entamoeba histolytica PH domain containing protein 0.0071 0.0065 0.0374
Entamoeba histolytica hypothetical protein 0.0045 0.0012 0.0025
Echinococcus granulosus protein tyrosine kinase 0.0045 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0208 0.1276
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0065 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Schistosoma mansoni protein kinase 0.0045 0.0012 0.0009
Entamoeba histolytica serine/threonine kinase, putative 0.0045 0.0012 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0008 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0769 0.1551 1
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Entamoeba histolytica protein kinase, putative 0.009 0.0106 0.0635
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0071 0.0065 0.0078
Echinococcus multilocularis hypothetical protein 0.0314 0.0583 0.0697
Echinococcus granulosus G protein coupled receptor kinase 1 0.2868 0.601 0.7185
Loa Loa (eye worm) AUR protein kinase 0.0077 0.0079 0.0079
Echinococcus granulosus beta 1 syntrophin 0.0071 0.0065 0.0078
Entamoeba histolytica hypothetical protein 0.0138 0.0208 0.1297
Loa Loa (eye worm) TK protein kinase 0.0045 0.0012 0.0012
Schistosoma mansoni protein kinase 0.0045 0.0012 0.0009
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Brugia malayi Regulator of G protein signaling domain containing protein 0.0769 0.1551 0.1551
Schistosoma mansoni hypothetical protein 0.0138 0.0208 0.0205
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Brugia malayi Pleckstrin Homology Domain 0.0071 0.0065 0.0065
Onchocerca volvulus 0.0071 0.0065 0.0366
Echinococcus granulosus insulin growth factor 1 receptor beta 0.005 0.0022 0.0026
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0045 0.0012 0.0012
Brugia malayi Uncoordinated protein 104 0.0071 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0769 0.1551 0.1551
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0071 0.0065 0.0078
Echinococcus granulosus tyrosine protein kinase HCK 0.0045 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0208 0.1276
Loa Loa (eye worm) hypothetical protein 0.0064 0.0051 0.0051
Schistosoma mansoni oxysterol-binding protein 1 0.0071 0.0065 0.0063
Brugia malayi C-terminal src kinase protein 1 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Brugia malayi PH domain containing protein 0.0071 0.0065 0.0065
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0071 0.0065 0.0063
Echinococcus granulosus activated cdc42 kinase 1 0.0045 0.0012 0.0014
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0064 0.0052 0.4282
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.009 0.0106 1
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0071 0.0065 0.0078
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Loa Loa (eye worm) uncoordinated protein 104 0.0071 0.0065 0.0065
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0065 0.0374
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0064 0.0052 0.4282
Echinococcus granulosus tyrosine protein kinase Srms 0.0045 0.0012 0.0014
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0045 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0208 0.1276
Trypanosoma cruzi aurora B kinase, putative 0.0077 0.0079 0.719
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0138 0.0208 0.1276
Trypanosoma cruzi PH domain containing protein, putative 0.0071 0.0065 0.5718
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0012 0.0014
Leishmania major hypothetical protein, conserved 0.0071 0.0065 0.5718
Echinococcus granulosus Pleckstrin y 0.0071 0.0065 0.0078
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0071 0.0065 0.0374
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0077 0.0079 0.0464
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Trichomonas vaginalis protein transport protein sec7, putative 0.0071 0.0065 0.035
Echinococcus multilocularis regulator of G protein signaling 0.0769 0.1551 0.1854
Echinococcus multilocularis kinase suppressor of Ras 1 0.0045 0.0012 0.0014
Brugia malayi Variant SH3 domain containing protein 0.0071 0.0065 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Echinococcus multilocularis calcium dependent secretion activator 1 0.0071 0.0065 0.0078
Echinococcus granulosus exocyst complex component 2 0.0138 0.0208 0.0249
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0012 0.0014
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0045 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase csk 0.0045 0.0012 0.0014
Brugia malayi SH2 domain containing protein 0.0045 0.0012 0.0012
Brugia malayi Syntrophin-1 0.0071 0.0065 0.0065
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Trypanosoma brucei protein kinase, putative 0.009 0.0106 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0045 0.0012 0.0014
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0071 0.0065 0.5718
Entamoeba histolytica protein kinase, putative 0.0077 0.0079 0.0464
Brugia malayi PH domain containing protein 0.0071 0.0065 0.0065
Schistosoma mansoni serine/threonine RGC 0.0045 0.0012 0.0009
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0045 0.0012 0.0012
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0071 0.0065 0.035
Echinococcus granulosus oxysterol binding protein 1 0.0071 0.0065 0.0078
Onchocerca volvulus 0.0071 0.0065 0.0366
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.0069 0.0061 0.0061
Echinococcus granulosus neuroglian 0.0064 0.0051 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) TK protein kinase 0.0045 0.0012 0.0012
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0071 0.0065 0.0366
Entamoeba histolytica hypothetical protein 0.0769 0.1551 1
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Echinococcus multilocularis Pleckstrin y 0.0071 0.0065 0.0078
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Echinococcus multilocularis integrin linked protein kinase 0.0045 0.0012 0.0014
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0065 0.0374
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0064 0.0051 0.0051
Echinococcus granulosus tyrosine protein kinase 0.0045 0.0012 0.0014
Echinococcus multilocularis tyrosine protein kinase csk 0.0045 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Toxoplasma gondii hypothetical protein 0.0071 0.0065 0.5718
Loa Loa (eye worm) RGC/RGC protein kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) AGC/AKT protein kinase 0.009 0.0106 0.0106
Echinococcus multilocularis natriuretic peptide receptor 1 0.0045 0.0012 0.0014
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0008 0.0005
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.009 0.0106 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0045 0.0012 0.0014
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.009 0.0106 1
Brugia malayi Guanylyl cyclase protein 23 0.0045 0.0012 0.0012
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0045 0.0012 0.0014
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0045 0.0012 0.0014
Loa Loa (eye worm) TK protein kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Schistosoma mansoni regulator of G protein signaling 0.0769 0.1551 0.1548
Schistosoma mansoni survival motor neuron protein 0.0058 0.0039 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0012 0.0009
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0077 0.0079 0.0464
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0045 0.0012 0.0014
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Loa Loa (eye worm) TK protein kinase 0.0045 0.0012 0.0012
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0374
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Trypanosoma cruzi PH domain containing protein, putative 0.0071 0.0065 0.5718
Echinococcus granulosus activin receptor type 0.0064 0.0052 0.0062
Trichomonas vaginalis centaurin/arf, putative 0.0071 0.0065 0.035
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0045 0.0012 0.0014
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0077 0.0079 0.0095
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Echinococcus multilocularis tyrosine protein kinase csk 0.0045 0.0012 0.0014
Echinococcus granulosus Pleckstrin y 0.0071 0.0065 0.0078
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0045 0.0012 0.0014
Echinococcus multilocularis dynamin 1 0.0071 0.0065 0.0078
Echinococcus multilocularis tyrosine protein kinase Srms 0.0045 0.0012 0.0014
Echinococcus multilocularis oxysterol binding protein 1 0.0071 0.0065 0.0078
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0065 0.0374
Loa Loa (eye worm) TK protein kinase 0.0045 0.0012 0.0012
Echinococcus multilocularis oxysterol binding protein 9 0.0071 0.0065 0.0078
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0071 0.0065 0.0063
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Trypanosoma cruzi hypothetical protein 0.0071 0.0065 0.5718
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0045 0.0012 0.0012
Echinococcus granulosus Oxysterol binding protein 11 0.0071 0.0065 0.0078
Schistosoma mansoni rho gtpase activating protein 0.0071 0.0065 0.0063
Entamoeba histolytica hypothetical protein, conserved 0.0045 0.0012 0.0025
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0071 0.0065 0.5718
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0071 0.0065 0.035
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0065 0.0374
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0045 0.0012 0.0014
Brugia malayi Raf kinase 0.0045 0.0012 0.0012
Schistosoma mansoni zinc finger protein 0.0071 0.0065 0.0063
Echinococcus multilocularis tyrosine protein kinase 0.0045 0.0012 0.0014
Echinococcus multilocularis GRB2 associated binding protein 3 0.0071 0.0065 0.0078
Echinococcus multilocularis semaphorin 5B 0.0314 0.0583 0.0697
Entamoeba histolytica protein kinase, putative 0.009 0.0106 0.0635
Entamoeba histolytica cell surface protease gp63, putative 0.0138 0.0208 0.1297
Loa Loa (eye worm) TK/RYK protein kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0314 0.0583 0.058
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Trypanosoma cruzi PH domain containing protein, putative 0.0071 0.0065 0.5718
Echinococcus multilocularis activin receptor type 0.0064 0.0052 0.0062
Brugia malayi hypothetical protein 0.0069 0.0061 0.0061
Schistosoma mansoni regulator of G protein signaling 0.0769 0.1551 0.1548
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Echinococcus multilocularis cytohesin 1 0.0071 0.0065 0.0078
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0012 0.0012
Echinococcus granulosus retinal guanylyl cyclase 2 0.0045 0.0012 0.0014
Loa Loa (eye worm) TK protein kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Loa Loa (eye worm) oxysterol binding protein 0.0071 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.009 0.0106 0.0635
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0045 0.0012 0.0009
Echinococcus granulosus pleckstrin y domain containing family A 0.0071 0.0065 0.0078
Entamoeba histolytica tyrosin kinase, putative 0.0183 0.0304 0.1921
Echinococcus multilocularis ephrin type A receptor 4 A 0.0045 0.0012 0.0014
Echinococcus granulosus pdz domain containing protein 0.0071 0.0065 0.0078
Schistosoma mansoni centaurin alpha 0.0071 0.0065 0.0063
Echinococcus granulosus tyrosine kinase 0.0045 0.0012 0.0014
Trypanosoma cruzi PH domain containing protein, putative 0.0071 0.0065 0.5718
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Echinococcus granulosus aurora kinase A 0.0077 0.0079 0.0095
Brugia malayi Immunoglobulin I-set domain containing protein 0.0109 0.0147 0.0147
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0071 0.0065 0.0065
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0106 0.0635
Onchocerca volvulus 0.0058 0.0039 0.0187
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0012 0.0014
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0045 0.0012 0.0014
Echinococcus granulosus c src tyrosine kinase 0.0045 0.0012 0.0014
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0071 0.0065 0.0078
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0071 0.0065 0.035
Loa Loa (eye worm) TK/CSK protein kinase 0.0045 0.0012 0.0012
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Echinococcus multilocularis tyrosine kinase 0.0045 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0769 0.1551 1
Trichomonas vaginalis conserved hypothetical protein 0.0769 0.1551 1
Loa Loa (eye worm) hypothetical protein 0.0314 0.0583 0.0583
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0045 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0522 0.0624
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0071 0.0065 0.0078
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0045 0.0012 0.0014
Entamoeba histolytica tyrosin kinase, putative 0.0045 0.0012 0.0025
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0065 0.5718
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Echinococcus multilocularis G protein coupled receptor kinase 6 0.3976 0.8365 1
Echinococcus multilocularis Oxysterol binding protein 11 0.0071 0.0065 0.0078
Schistosoma mansoni protein kinase 0.0045 0.0012 0.0009
Entamoeba histolytica hypothetical protein 0.0045 0.0012 0.0025
Brugia malayi SRC-1 0.0045 0.0012 0.0012
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Brugia malayi plexin A 0.0876 0.1778 0.1778
Brugia malayi hypothetical protein 0.0045 0.0012 0.0012
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0064 0.0051 0.0061
Schistosoma mansoni hypothetical protein 0.0071 0.0065 0.0063
Echinococcus granulosus regulator of G protein signaling 7 0.0769 0.1551 0.1854
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0138 0.0208 0.1276
Entamoeba histolytica serine/threonine kinase, putative 0.0045 0.0012 0.0025
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0106 0.0635
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0045 0.0012 0.0009
Echinococcus granulosus defective proboscis extension response 0.0064 0.0051 0.0061
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Brugia malayi Sema domain containing protein 0.0314 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0314 0.0583 0.0583
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0065 0.0374
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0769 0.1551 0.1548
Echinococcus multilocularis Pleckstrin y 0.0071 0.0065 0.0078
Echinococcus multilocularis regulator of G protein signaling 7 0.0769 0.1551 0.1854
Trypanosoma cruzi hypothetical protein 0.0071 0.0065 0.5718
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.009 0.0106 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0313 0.058 0.058
Brugia malayi regulator of G-protein signaling rgs-7 0.0769 0.1551 0.1551
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0071 0.0065 0.0078
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.3638 0.7645 0.7645
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0071 0.0065 0.0065
Entamoeba histolytica protein kinase domain containing protein 0.0064 0.0052 0.0286
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0071 0.0065 0.0065
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0012 0.0014
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2868 0.601 0.7185
Echinococcus granulosus semaphorin 5B 0.0314 0.0583 0.0697
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Loa Loa (eye worm) hypothetical protein 0.0314 0.0583 0.0583
Schistosoma mansoni protein kinase 0.0064 0.0052 0.0049
Brugia malayi Tyrosine-protein kinase PR2 0.0045 0.0012 0.0012
Schistosoma mansoni axis inhibition protein axin 0.0769 0.1551 0.1548
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0045 0.0012 0.0012
Trypanosoma cruzi hypothetical protein 0.0071 0.0065 0.5718
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Onchocerca volvulus 0.0071 0.0065 0.0366
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0138 0.0208 0.1276
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0064 0.0051 0.0051
Entamoeba histolytica hypothetical protein 0.0045 0.0012 0.0025
Echinococcus multilocularis protein tyrosine kinase 0.0045 0.0012 0.0014
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0769 0.1551 0.1548
Entamoeba histolytica hypothetical protein 0.0045 0.0012 0.0025
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0769 0.1551 1
Echinococcus granulosus twitchin 0.0083 0.0091 0.0109
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0045 0.0012 0.0014
Entamoeba histolytica PH domain containing protein 0.0071 0.0065 0.0374
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Entamoeba histolytica protein kinase , putative 0.0077 0.0079 0.0464
Schistosoma mansoni plexin 0.0425 0.0818 0.0815
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Echinococcus granulosus regulator of G protein signaling 7 0.0769 0.1551 0.1854
Echinococcus granulosus tyrosine protein kinase csk 0.0045 0.0012 0.0014
Entamoeba histolytica hypothetical protein 0.009 0.0106 0.0635
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0043 0.0043
Loa Loa (eye worm) TK/DDR protein kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Schistosoma mansoni protein kinase 0.0045 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0208 0.1276
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0071 0.0065 0.0374
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Echinococcus multilocularis expressed protein 0.0769 0.1551 0.1854
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0045 0.0012 0.0025
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0079 0.044
Brugia malayi PH domain containing protein 0.0071 0.0065 0.0065
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.009 0.0106 1
Brugia malayi protein-tyrosine kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) rho-GTPase-activating 0.0071 0.0065 0.0065
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0045 0.0012 0.0012
Brugia malayi hypothetical protein 0.0769 0.1551 0.1551
Echinococcus granulosus retinal guanylyl cyclase 2 0.0045 0.0012 0.0014
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Echinococcus granulosus oxysterol binding protein 3 0.0071 0.0065 0.0078
Loa Loa (eye worm) hypothetical protein 0.0286 0.0522 0.0522
Echinococcus granulosus dynamin 1 0.0071 0.0065 0.0078
Echinococcus multilocularis oxysterol binding protein 3 0.0071 0.0065 0.0078
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0012 0.0014
Echinococcus multilocularis tyrosine protein kinase Abl 0.0045 0.0012 0.0014
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0012 0.0014
Brugia malayi Protein kinase domain containing protein 0.009 0.0106 0.0106
Loa Loa (eye worm) sema domain-containing protein 0.0314 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0008 0.0009
Echinococcus granulosus regulator of G protein signaling 3 0.0769 0.1551 0.1854
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Entamoeba histolytica protein kinase, putative 0.009 0.0106 0.0635
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0064 0.0052 0.4282
Leishmania major folate/biopterin transporter, putative 0.009 0.0106 1
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0064 0.0051 0.0048
Entamoeba histolytica protein kinase, putative 0.0077 0.0079 0.0464
Echinococcus granulosus insulin receptor 0.0045 0.0012 0.0014
Schistosoma mansoni protein kinase 0.0077 0.0079 0.0076
Loa Loa (eye worm) SRC-1 0.0045 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0769 0.1551 1
Plasmodium falciparum protein kinase, putative 0.0064 0.0052 0.4282
Echinococcus multilocularis tyrosine protein kinase shark 0.0045 0.0012 0.0014
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0045 0.0012 0.0025
Entamoeba histolytica serine/threonine kinase, putative 0.0045 0.0012 0.0025
Echinococcus multilocularis axis inhibition protein axin 0.0769 0.1551 0.1854
Echinococcus granulosus beta-adrenergic receptor kinase 0.3638 0.7645 0.914
Echinococcus multilocularis Immunoglobulin 0.0064 0.0051 0.0061
Echinococcus multilocularis roundabout 2 0.0069 0.0061 0.0073
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0071 0.0065 0.0078
Schistosoma mansoni protein kinase 0.0064 0.0052 0.0049
Toxoplasma gondii aurora kinase 0.0077 0.0079 0.719
Trichomonas vaginalis centaurin gamma, putative 0.0071 0.0065 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0208 0.1276
Loa Loa (eye worm) hypothetical protein 0.0314 0.0583 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Entamoeba histolytica receptor protein kinase, putative 0.0045 0.0012 0.0025
Trichomonas vaginalis alpha chimerin, putative 0.0071 0.0065 0.035
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0071 0.0065 0.0374
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0071 0.0065 0.5718
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0106 0.0635
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Trypanosoma brucei PH domain containing protein, putative 0.0071 0.0065 0.5718
Loa Loa (eye worm) RGC/RGC protein kinase 0.0045 0.0012 0.0012
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Onchocerca volvulus Putative zinc finger protein 0.0071 0.0065 0.0366
Loa Loa (eye worm) hypothetical protein 0.0769 0.1551 0.1551
Entamoeba histolytica hypothetical protein 0.0138 0.0208 0.1297
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0012 0.0014
Echinococcus granulosus tyrosine kinase 0.0045 0.0012 0.0014
Trypanosoma brucei rac serine-threonine kinase, putative 0.009 0.0106 1
Schistosoma mansoni cell adhesion molecule 0.0069 0.0061 0.0059
Loa Loa (eye worm) hypothetical protein 0.0064 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Loa Loa (eye worm) hypothetical protein 0.0069 0.0061 0.0061
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0045 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0769 0.1551 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase csk 0.0045 0.0012 0.0014
Brugia malayi ephrin receptor 1 precursor 0.0045 0.0012 0.0012
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0045 0.0012 0.0014
Schistosoma mansoni dynamin 0.0071 0.0065 0.0063
Echinococcus granulosus regulator of G protein signaling 3 0.0769 0.1551 0.1854
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0079 0.0076
Loa Loa (eye worm) hypothetical protein 0.0314 0.0583 0.0583
Loa Loa (eye worm) cytohesin 3 0.0071 0.0065 0.0065
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0077 0.0079 0.0095
Onchocerca volvulus 0.0739 0.1485 1
Toxoplasma gondii hypothetical protein 0.0071 0.0065 0.5718
Echinococcus granulosus Pleckstrin y 0.0071 0.0065 0.0078
Entamoeba histolytica hypothetical protein 0.0138 0.0208 0.1297
Echinococcus multilocularis epidermal growth factor receptor 0.0045 0.0012 0.0014
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0071 0.0065 0.5718
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Leishmania major hypothetical protein, conserved 0.0071 0.0065 0.5718
Echinococcus multilocularis regulator of G protein signaling 3 0.0769 0.1551 0.1854
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.009 0.0106 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0043 0.0008 0.0005
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0064 0.0051 0.0061
Loa Loa (eye worm) TK/Met protein kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) AUR protein kinase 0.0077 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.006 0.0043 0.0043
Brugia malayi hypothetical protein 0.0769 0.1551 0.1551
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0769 0.1551 0.1551
Trypanosoma cruzi serine/threonine protein kinase, putative 0.009 0.0106 1
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Brugia malayi hypothetical protein 0.0314 0.0583 0.0583
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.009 0.0106 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Loa Loa (eye worm) hypothetical protein 0.0739 0.1485 0.1485
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Echinococcus granulosus tyrosine kinase 0.0045 0.0012 0.0014
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0106 0.0635
Entamoeba histolytica serine/threonine kinase, putative 0.0045 0.0012 0.0025
Trypanosoma cruzi NIMA-related kinase, putative 0.009 0.0106 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0045 0.0012 0.0012
Brugia malayi PH domain containing protein 0.0071 0.0065 0.0065
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0071 0.0065 0.0078
Entamoeba histolytica hypothetical protein 0.0045 0.0012 0.0025
Trichomonas vaginalis protein transport protein sec7, putative 0.0071 0.0065 0.035
Echinococcus granulosus serine/threonine protein kinase 0.009 0.0106 0.0126
Schistosoma mansoni hypothetical protein 0.0425 0.0818 0.0815
Echinococcus multilocularis pleckstrin y domain containing family A 0.0071 0.0065 0.0078
Brugia malayi PXA domain containing protein 0.0769 0.1551 0.1551
Schistosoma mansoni protein kinase 0.0064 0.0052 0.0049
Echinococcus multilocularis neuroglian 0.0064 0.0051 0.0061
Schistosoma mansoni vav2 0.0071 0.0065 0.0063
Echinococcus granulosus activated cdc42 kinase 1 0.0045 0.0012 0.0014
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0045 0.0012 0.0012
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.0314 0.0583 0.0583
Loa Loa (eye worm) RGC/RGC protein kinase 0.0045 0.0012 0.0012
Brugia malayi Plexin repeat family protein 0.0739 0.1485 0.1485
Loa Loa (eye worm) TK protein kinase 0.0045 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0045 0.0012 0.0025
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Brugia malayi Cadps2 protein 0.0071 0.0065 0.0065
Loa Loa (eye worm) TK/ROR protein kinase 0.0045 0.0012 0.0012
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Entamoeba histolytica hypothetical protein 0.0045 0.0012 0.0025
Trypanosoma cruzi hypothetical protein 0.0071 0.0065 0.5718
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Loa Loa (eye worm) TK/INSR protein kinase 0.0045 0.0012 0.0012
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.009 0.0106 1
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0138 0.0208 0.1276
Echinococcus granulosus tyrosine protein kinase pr2 0.0045 0.0012 0.0014
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0071 0.0065 0.0078
Echinococcus multilocularis FL cytokine receptor 0.0045 0.0012 0.0014
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0071 0.0065 0.0078
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Schistosoma mansoni syntrophin 0.0071 0.0065 0.0063
Brugia malayi Tyrosine-protein kinase abl-1 0.0045 0.0012 0.0012
Entamoeba histolytica p21-activated kinase 0.009 0.0106 0.0635
Brugia malayi bone morphogenetic protein type 1 receptor 0.0045 0.0012 0.0012
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0071 0.0065 0.5718
Brugia malayi Fibronectin type III domain containing protein 0.0069 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Blk 0.0045 0.0012 0.0014
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0071 0.0065 0.0078
Brugia malayi PH domain containing protein 0.0071 0.0065 0.0065
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0071 0.0065 0.035
Schistosoma mansoni hypothetical protein 0.0071 0.0065 0.0063
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Echinococcus multilocularis activated cdc42 kinase 1 0.0045 0.0012 0.0014
Echinococcus granulosus oxysterol binding protein 9 0.0071 0.0065 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Entamoeba histolytica tyrosin kinase, putative 0.0045 0.0012 0.0025
Toxoplasma gondii Oxysterol-binding protein 0.0071 0.0065 0.5718
Brugia malayi Cytohesin 3 0.0071 0.0065 0.0065
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0071 0.0065 0.0078
Entamoeba histolytica hypothetical protein 0.0769 0.1551 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0769 0.1551 0.1551
Echinococcus granulosus semaphorin 1A 0.0314 0.0583 0.0697
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Schistosoma mansoni hypothetical protein 0.0045 0.0012 0.0009
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.005 0.0022 0.0026
Brugia malayi Dynamin 0.0071 0.0065 0.0065
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0045 0.0012 0.0025
Entamoeba histolytica ankyrin repeat protein 0.0045 0.0012 0.0025
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0071 0.0065 0.0063
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0045 0.0012 0.0014
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Echinococcus multilocularis protein kinase 0.0045 0.0012 0.0014
Echinococcus granulosus epidermal growth factor receptor 0.0045 0.0012 0.0014
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0106 0.0635
Brugia malayi Receptor family ligand binding region containing protein 0.0045 0.0012 0.0012
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0045 0.0012 0.0012
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0071 0.0065 0.0065
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.009 0.0106 1
Echinococcus granulosus Rho GTPase activating protein 24 0.0071 0.0065 0.0078
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Schistosoma mansoni fibrocystin l 0.0138 0.0208 0.0205
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0045 0.0012 0.0009
Echinococcus granulosus plexin a4 0.0876 0.1778 0.2125
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0071 0.0065 0.0374
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0425 0.0818 0.0818
Echinococcus multilocularis transcription factor collier 0.0138 0.0208 0.0249
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0008 0.0005
Brugia malayi TBC domain containing protein 0.0071 0.0065 0.0065
Echinococcus multilocularis actin binding protein anillin 0.0071 0.0065 0.0078
Schistosoma mansoni hypothetical protein 0.0071 0.0065 0.0063
Onchocerca volvulus 0.0071 0.0065 0.0366
Echinococcus multilocularis insulin receptor 0.0045 0.0012 0.0014
Brugia malayi hypothetical protein 0.0045 0.0012 0.0012
Leishmania major protein kinase, putative 0.009 0.0106 1
Loa Loa (eye worm) Plekhf2 protein 0.0071 0.0065 0.0065
Entamoeba histolytica cysteine surface protein, putative 0.0045 0.0012 0.0025
Schistosoma mansoni hypothetical protein 0.0058 0.0039 0.0036
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0071 0.0065 0.5718
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0071 0.0065 0.0078
Trypanosoma cruzi NIMA-related kinase, putative 0.009 0.0106 1
Brugia malayi MAX-1A 0.0071 0.0065 0.0065
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0769 0.1551 0.1854
Echinococcus multilocularis tyrosine protein kinase pr2 0.0045 0.0012 0.0014
Brugia malayi Variant SH3 domain containing protein 0.0071 0.0065 0.0065
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.009 0.0106 1
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0374
Echinococcus multilocularis Ras associated and pleckstrin y 0.0071 0.0065 0.0078
Brugia malayi hypothetical protein 0.0286 0.0522 0.0522
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0012 0.0009
Loa Loa (eye worm) PH domain-containing protein 0.0071 0.0065 0.0065
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0138 0.0208 0.1276
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Echinococcus multilocularis axis inhibition protein axin 0.0769 0.1551 0.1854
Schistosoma mansoni nephrin 0.0069 0.0061 0.0059
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Echinococcus granulosus tyrosine protein kinase Lyn 0.0064 0.0052 0.0062
Echinococcus granulosus retinal guanylyl cyclase 2 0.0045 0.0012 0.0014
Trypanosoma cruzi rac serine-threonine kinase, putative 0.009 0.0106 1
Loa Loa (eye worm) TK protein kinase 0.0045 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0045 0.0012 0.0025
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Onchocerca volvulus 0.0071 0.0065 0.0366
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0374
Loa Loa (eye worm) hypothetical protein 0.0064 0.0051 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0079 0.044
Echinococcus multilocularis Immunoglobulin 0.0064 0.0051 0.0061
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0045 0.0012 0.0012
Brugia malayi Plekhf2 protein 0.0071 0.0065 0.0065
Schistosoma mansoni semaphorin 5-related 0.0314 0.0583 0.058
Loa Loa (eye worm) TK protein kinase 0.0045 0.0012 0.0012
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.3976 0.8365 0.8365
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Schistosoma mansoni goodpasture antigen-binding protein 0.0071 0.0065 0.0063
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0045 0.0012 0.0012
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0064 0.0052 0.0062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0374
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0045 0.0012 0.0014
Echinococcus multilocularis aurora kinase A 0.0077 0.0079 0.0095
Echinococcus multilocularis Pleckstrin y 0.0071 0.0065 0.0078
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0065 0.0374
Loa Loa (eye worm) hypothetical protein 0.0069 0.0061 0.0061
Schistosoma mansoni zinc finger protein 0.0071 0.0065 0.0063
Echinococcus multilocularis tyrosine protein kinase csk 0.0045 0.0012 0.0014
Schistosoma mansoni hypothetical protein 0.0071 0.0065 0.0063
Echinococcus granulosus myotubularin protein 13 0.0071 0.0065 0.0078
Entamoeba histolytica hypothetical protein 0.0045 0.0012 0.0025
Schistosoma mansoni ephrin receptor 0.0045 0.0012 0.0009
Echinococcus multilocularis c src tyrosine kinase 0.0045 0.0012 0.0014
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0045 0.0012 0.0014
Brugia malayi integrin-linked kinase 0.0045 0.0012 0.0012
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0138 0.0208 0.1297
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.009 0.0106 1
Loa Loa (eye worm) hypothetical protein 0.0769 0.1551 0.1551
Echinococcus granulosus GRB2 associated binding protein 3 0.0071 0.0065 0.0078
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0045 0.0012 0.0014
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0045 0.0012 0.0025
Schistosoma mansoni regulator of G protein signaling 0.0769 0.1551 0.1548
Schistosoma mansoni protein kinase 0.0045 0.0012 0.0009
Echinococcus multilocularis Rho GTPase activating protein 24 0.0071 0.0065 0.0078
Toxoplasma gondii AtPH1 family protein 0.0071 0.0065 0.5718
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Loa Loa (eye worm) sema domain-containing protein 0.0314 0.0583 0.0583
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0071 0.0065 0.0078
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0769 0.1551 1
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Schistosoma mansoni z-protein (S1r protein) 0.0769 0.1551 0.1548
Echinococcus granulosus epidermal growth factor receptor 0.0045 0.0012 0.0014
Loa Loa (eye worm) RGS-3 protein 0.0769 0.1551 0.1551
Onchocerca volvulus 0.0071 0.0065 0.0366
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Toxoplasma gondii phosphatidylinositol transfer protein 0.0071 0.0065 0.5718
Echinococcus granulosus natriuretic peptide receptor 1 0.0045 0.0012 0.0014
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0012 0.0014
Plasmodium falciparum serine/threonine protein kinase, putative 0.0077 0.0079 0.719
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0012 0.0014
Echinococcus granulosus calcium dependent secretion activator 1 0.0071 0.0065 0.0078
Schistosoma mansoni serine/threonine-protein kinase 0.009 0.0106 0.0103
Echinococcus granulosus integrin linked protein kinase 0.0045 0.0012 0.0014
Schistosoma mansoni tyrosine protein kinase 0.0045 0.0012 0.0009
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0769 0.1551 0.1854
Schistosoma mansoni hypothetical protein 0.0138 0.0208 0.0205
Brugia malayi PH domain containing protein 0.0071 0.0065 0.0065
Schistosoma mansoni protein kinase 0.0045 0.0012 0.0009
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0045 0.0012 0.0014
Schistosoma mansoni serine/threonine-protein kinase 0.009 0.0106 0.0103
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0045 0.0012 0.0025
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Brugia malayi IPT/TIG domain containing protein 0.0138 0.0208 0.0208
Entamoeba histolytica protein kinase, putative 0.009 0.0106 0.0635
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Entamoeba histolytica protein kinase, putative 0.0045 0.0012 0.0025
Entamoeba histolytica hypothetical protein 0.0045 0.0012 0.0025
Brugia malayi Sema domain containing protein 0.0314 0.0583 0.0583
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Entamoeba histolytica hypothetical protein, conserved 0.0071 0.0065 0.0374
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0071 0.0065 0.035
Echinococcus granulosus roundabout 2 0.0069 0.0061 0.0073
Plasmodium falciparum calcium-dependent protein kinase 7 0.009 0.0106 1
Trypanosoma cruzi hypothetical protein 0.0071 0.0065 0.5718
Echinococcus multilocularis regulator of G protein signaling 3 0.0769 0.1551 0.1854
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Schistosoma mansoni goodpasture antigen-binding protein 0.0071 0.0065 0.0063
Schistosoma mansoni protein tyrosine kinase 0.0045 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0064 0.0051 0.0051
Trichomonas vaginalis AGC family protein kinase 0.009 0.0106 0.0612
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0071 0.0065 0.0078
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0045 0.0012 0.0014
Brugia malayi regulator of G-protein signaling egl-10 0.0769 0.1551 0.1551
Trichomonas vaginalis kinesin light chain, putative 0.0071 0.0065 0.035
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Echinococcus multilocularis myotubularin protein 13 0.0071 0.0065 0.0078
Entamoeba histolytica tyrosine kinase, putative 0.0045 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Plasmodium vivax PH domain containing protein 0.0071 0.0065 0.5718
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Brugia malayi hypothetical protein 0.0314 0.0583 0.0583
Echinococcus granulosus raf serine:threonine protein kinase 0.0045 0.0012 0.0014
Brugia malayi serine/threonine kinase 12 0.0077 0.0079 0.0079
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0003 0.0003
Echinococcus granulosus expressed protein 0.0769 0.1551 0.1854
Entamoeba histolytica protein kinase, putative 0.009 0.0106 0.0635
Trypanosoma cruzi hypothetical protein 0.0071 0.0065 0.5718
Schistosoma mansoni tyrosine kinase 0.0045 0.0012 0.0009
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Brugia malayi Protein kinase domain containing protein 0.0045 0.0012 0.0012
Echinococcus multilocularis plexin a4 0.0876 0.1778 0.2125
Toxoplasma gondii protein kinase domain-containing protein 0.009 0.0106 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.0208 0.0208
Loa Loa (eye worm) TK/FER protein kinase 0.0045 0.0012 0.0012
Brugia malayi PXA domain containing protein 0.0769 0.1551 0.1551
Loa Loa (eye worm) hypothetical protein 0.0071 0.0065 0.0065
Echinococcus granulosus transcription factor collier 0.0138 0.0208 0.0249
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.009 0.0106 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0769 0.1551 0.1548
Entamoeba histolytica PH domain containing protein 0.0071 0.0065 0.0374
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0071 0.0065 0.5718
Brugia malayi Oxysterol binding protein 0.0071 0.0065 0.0065
Brugia malayi serine/threonine protein kinase 6 0.0077 0.0079 0.0079
Brugia malayi Probable exocyst complex component Sec5 0.0138 0.0208 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0065 0.035
Schistosoma mansoni protein kinase 0.0045 0.0012 0.0009
Entamoeba histolytica hypothetical protein 0.0045 0.0012 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0012 0.0009
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0012 0.0025
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.3976 0.8365 0.8365
Echinococcus multilocularis tyrosine protein kinase Blk 0.0045 0.0012 0.0014
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0043 0.0043

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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